Automatic annotation results for AC.fasta

Ssequence id

Locus

Description

Alignment Score

E-value

% Sequence Identity

EC number

COG Function

KEGG Pathways

GeneOntology

ACL00000001

Ribosomal_S30 domain containing protein

245

9e-22

70% (42/60)

ACL00000002

VATF

Probable vacuolar ATP synthase subunit F related cluster

164

3e-11

53% (30/56)

3.6.3.14

Energy production and conversion

GO:0006754|ATP biosynthesis|IEA; GO:0015078|hydrogen ion transporter activity|IEA; GO:0015986|ATP synthesis coupled proton transport|IEA; GO:0015992|proton transport|IEA; GO:0016469|proton-transporting two-sector ATPase complex|IEA; GO:0016787|hydrolase activity|IEA; GO:0046933|hydrogen-transporting ATP synthase activity, rotational mechanism|IEA; GO:0046961|hydrogen-transporting ATPase activity, rotational mechanism|IEA

ACL00000008

Ras-related protein Rap-1 related cluster

525

1e-52

68% (103/151)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00000011

CBS domain protein related cluster

175

9e-12

28% (51/178)

General function prediction only

ACL00000012

Rpl31

60S ribosomal protein L31 related cluster

422

7e-41

68% (80/117)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000016

multi-domain protein

132

1e-08

22% (26/114)

ACL00000018

Ubiquitin related cluster

390

5e-37

96% (78/81)

Posttranslational modification, protein turnover, chaperones

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000019

Peroxidase ppod11 related cluster

132

2e-07

31% (42/134)

GO:0004601|peroxidase activity|IEA

ACL00000022

Heat shock cognate protein related cluster

2464

0.0

76% (465/609)

GO:0005524|ATP binding|IEA; GO:0006457|protein folding|IEA; GO:0051082|unfolded protein binding|IEA

ACL00000025

PPB

Alkaline phosphatase related cluster

360

2e-33

51% (80/155)

3.1.3.1

Inorganic ion transport and metabolism

GO:0000287|magnesium ion binding|IEA; GO:0004035|alkaline phosphatase activity|IEA; GO:0008152|metabolism|IEA; GO:0016021|integral to membrane|IEA; GO:0016787|hydrolase activity|IEA

ACL00000026

AhpC/TSA family protein related cluster

375

2e-35

47% (73/153)

ACL00000027

multi-domain protein

139

6e-09

22% (55/242)

ACL00000030

F27G19.90; 3' exoribonuclease family domain 1-containing protein

343

1e-31

37% (78/206)

ACL00000032

multi-domain protein

125

2e-07

15% (35/223)

ACL00000033

unclassified

ACL00000034

putative reductase [Streptomyces avermitilis MA-4680] dbj|BAC68620.1| putative reductase [Streptomyces avermitilis MA-4680]

205

4e-15

32% (55/168)

ACL00000035

CAH

Carbonic anhydrase precursor related cluster

271

3e-23

38% (58/150)

4.2.1.1

Inorganic ion transport and metabolism

Nitrogen metabolism

GO:0004089|carbonate dehydratase activity|IEA; GO:0006730|one-carbon compound metabolism|IEA; GO:0008270|zinc ion binding|IEA; GO:0016829|lyase activity|IEA; GO:0042597|periplasmic space|IEA

ACL00000036

[HC] COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

404

2e-39

44% (73/163)

ACL00000037

Transcriptional regulator related cluster

154

7e-10

30% (42/137)

GO:0003677|DNA binding|IEA; GO:0003700|transcription factor activity|IEA; GO:0005622|intracellular|IEA; GO:0006350|transcription|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA

ACL00000038

unclassified

ACL00000039

Unassigned protein

155

3e-10

44% (32/72)

ACL00000040

unclassified

ACL00000041

unclassified

ACL00000042

UGDH

UDP-glucose dehydrogenase related cluster

317

2e-60

60% (57/95)

1.1.1.22

Cell wall/membrane/envelope biogenesis

Nucleotide sugars metabolism Pentose and glucuronate interconversions Starch and sucrose metabolism

GO:0006118|electron transport|IEA

ACL00000043

Cytochrome B5 related cluster

253

3e-21

36% (51/138)

ACL00000044

unclassified

ACL00000045

TPP1

Tripeptidyl-peptidase I precursor related cluster

154

1e-31

60% (33/55)

3.4.14.9

GO:0004252|serine-type endopeptidase activity|IEA; GO:0005764|lysosome|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA; GO:0019131|tripeptidyl-peptidase I activity|IEA

ACL00000046

unclassified

ACL00000048

Histone H4 related cluster

422

6e-41

96% (82/85)

Chromatin structure and dynamics

GO:0000786|nucleosome|IEA; GO:0003677|DNA binding|IEA; GO:0005634|nucleus|IEA; GO:0005694|chromosome|IEA; GO:0006334|nucleosome assembly|IEA; GO:0007001|chromosome organization and biogenesis (sensu Eukaryota)|IEA

ACL00000049

[T] COG0589 Universal stress protein UspA and related nucleotide-binding proteins

118

6e-06

28% (42/150)

Signal transduction mechanisms

ACL00000051

unclassified

ACL00000052

unclassified

ACL00000053

Eif3s6ip

Eukaryotic translation initiation factor 3 subunit 6 interacting protein related cluster

392

2e-37

46% (77/167)

GO:0006412|protein biosynthesis|IEA

ACL00000054

GTP-binding protein yptV4 related cluster

753

4e-79

74% (144/193)

General function prediction only

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00000055

unclassified

ACL00000056

3-alpha-hydroxysteroid dehydrogenase-like protein related cluster

193

1e-14

40% (49/120)

GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000057

COX12

Cytochrome c oxidase polypeptide VIb related cluster

195

1e-14

51% (32/62)

1.9.3.1

Oxidative phosphorylation

GO:0004129|cytochrome-c oxidase activity|IEA; GO:0005739|mitochondrion|IEA; GO:0006118|electron transport|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000058

DUF985 domain containing protein

471

1e-47

51% (70/137)

ACL00000059

RPL35

Ribosomal protein L35 related cluster

407

3e-39

68% (84/122)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000060

FBOX domain containing protein

97

1e-05

31% (13/41)

ACL00000061

PSMB6

Proteasome subunit related cluster

55

8e-64

46% (12/26)

3.4.25.1

Posttranslational modification, protein turnover, chaperones

Proteasome

GO:0004175|endopeptidase activity|IEA; GO:0005829|cytosol|IEA; GO:0005839|proteasome core complex (sensu Eukaryota)|IEA; GO:0006511|ubiquitin-dependent protein catabolism|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00000063

multi-domain protein

134

2e-08

21% (48/222)

ACL00000064

EIF4A2

Eukaryotic initiation factor 4A-II related cluster

593

2e-60

68% (109/159)

GO:0003676|nucleic acid binding|IEA; GO:0003677|DNA binding|IEA; GO:0003723|RNA binding|IEA; GO:0003743|translation initiation factor activity|IEA; GO:0003743|translation initiation factor activity|TAS; GO:0004386|helicase activity|IEA; GO:0004386|helicase activity|TAS; GO:0005524|ATP binding|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006446|regulation of translational initiation|TAS; GO:0008026|ATP-dependent helicase activity|IEA; GO:0016281|eukaryotic translation initiation factor 4F complex|TAS

ACL00000065

unclassified

ACL00000067

multi-domain protein

125

1e-07

30% (37/121)

ACL00000069

Rho GDP-dissociation inhibitor related cluster

503

5e-50

50% (100/200)

GO:0005094|Rho GDP-dissociation inhibitor activity|IEA; GO:0005737|cytoplasm|IEA

ACL00000070

Histone protein Hist2h3c1 related cluster

441

6e-43

68% (94/138)

Chromatin structure and dynamics

GO:0000786|nucleosome|IEA; GO:0003677|DNA binding|IEA; GO:0005634|nucleus|IEA; GO:0005694|chromosome|IEA; GO:0006334|nucleosome assembly|IEA; GO:0007001|chromosome organization and biogenesis (sensu Eukaryota)|IEA

ACL00000072

Sulfide-quinone reductase related cluster

368

1e-34

51% (61/119)

GO:0006118|electron transport|IEA; GO:0015036|disulfide oxidoreductase activity|IEA

ACL00000073

SQRDL

Sulfide:quinone oxidoreductase, mitochondrial precursor related cluster

553

1e-55

49% (102/206)

1.-.-.-

GO:0005739|mitochondrion|IEA; GO:0006118|electron transport|IEA; GO:0015036|disulfide oxidoreductase activity|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000077

probable transmembrane protein

377

5e-36

57% (71/123)

ACL00000078

Putative transport protein related cluster

223

1e-17

33% (48/142)

ACL00000079

ATP synthase subunit, probable related cluster

150

1e-09

48% (25/52)

Energy production and conversion

GO:0015986|ATP synthesis coupled proton transport|IEA; GO:0016469|proton-transporting two-sector ATPase complex|IEA; GO:0016787|hydrolase activity|IEA; GO:0046933|hydrogen-transporting ATP synthase activity, rotational mechanism|IEA; GO:0046961|hydrogen-transporting ATPase activity, rotational mechanism|IEA

ACL00000080

Putative amino acid efflux transmembrane protein related cluster

207

8e-38

66% (38/57)

Amino acid transport and metabolism

GO:0005293|lysine permease activity|IEA; GO:0006865|amino acid transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA

ACL00000084

RNZ2

Zinc phosphodiesterase ELAC protein 2 related cluster

191

5e-14

37% (37/100)

3.1.26.11

GO:0004518|nuclease activity|IEA; GO:0004519|endonuclease activity|IEA; GO:0005634|nucleus|IEA; GO:0008033|tRNA processing|IEA; GO:0008151||IEA; GO:0016787|hydrolase activity|IEA

ACL00000085

unclassified

ACL00000086

GGLO

L-gulonolactone oxidase related cluster

386

8e-37

44% (74/168)

1.1.3.8

Ascorbate and aldarate metabolism

GO:0003885|D-arabinono-1,4-lactone oxidase activity|IEA; GO:0005792|microsome|IEA; GO:0006118|electron transport|IEA; GO:0009058|biosynthesis|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016899|oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor|IEA; GO:0019853|L-ascorbic acid biosynthesis|IEA; GO:0050105|L-gulonolactone oxidase activity|IEA

ACL00000087

ABC transporter AbcH.2 related cluster

721

2e-75

57% (139/243)

Defense mechanisms

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0016887|ATPase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

ACL00000088

TXNRD3

Thioredoxin reductase TR1 related cluster

205

1e-15

66% (40/60)

GO:0005737|cytoplasm|IEA; GO:0006118|electron transport|IEA; GO:0015036|disulfide oxidoreductase activity|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016654|oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor|IEA; GO:0050660|FAD binding|IEA

ACL00000089

rpmH

Ribosomal protein L34 related cluster

142

1e-08

56% (25/44)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00000090

unclassified

ACL00000091

unclassified

ACL00000092

unclassified

ACL00000093

unclassified

ACL00000094

SUCA

Succinyl-CoA ligase [GDP-forming] alpha-chain, mitochondrial precursor related cluster

995

1e-107

68% (201/293)

6.2.1.4

Energy production and conversion

GO:0003824|catalytic activity|IEA; GO:0004776|succinate-CoA ligase (GDP-forming) activity|IEA; GO:0005525|GTP binding|IEA; GO:0005739|mitochondrion|IEA; GO:0006099|tricarboxylic acid cycle|IEA; GO:0008152|metabolism|IEA; GO:0016874|ligase activity|IEA

ACL00000095

unclassified

ACL00000097

unclassified

ACL00000099

ARL10B

ADP-ribosylation factor-like protein related cluster

535

7e-54

64% (99/154)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00000101

ATPB

ATP synthase beta chain related cluster

198

8e-15

74% (37/50)

3.6.3.14

Energy production and conversion

ATP synthesis Oxidative phosphorylation

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0006754|ATP biosynthesis|IEA; GO:0008553|hydrogen-exporting ATPase activity, phosphorylative mechanism|IEA; GO:0015078|hydrogen ion transporter activity|IEA; GO:0015986|ATP synthesis coupled proton transport|IEA; GO:0015992|proton transport|IEA; GO:0016021|integral to membrane|IEA; GO:0016469|proton-transporting two-sector ATPase complex|IEA; GO:0016787|hydrolase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA; GO:0045255|hydrogen-translocating F-type ATPase complex|IEA; GO:0046933|hydrogen-transporting ATP synthase activity, rotational mechanism|IEA; GO:0046961|hydrogen-transporting ATPase activity, rotational mechanism|IEA

ACL00000102

rps28-2

40S ribosomal protein S28 related cluster

148

3e-09

72% (31/43)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000103

Histone H4 related cluster

404

6e-39

96% (79/82)

Chromatin structure and dynamics

GO:0000786|nucleosome|IEA; GO:0003677|DNA binding|IEA; GO:0005634|nucleus|IEA; GO:0005694|chromosome|IEA; GO:0006334|nucleosome assembly|IEA; GO:0007001|chromosome organization and biogenesis (sensu Eukaryota)|IEA

ACL00000104

Peptidyl-prolyl cis-trans isomerase related cluster

598

6e-61

56% (124/220)

Posttranslational modification, protein turnover, chaperones

GO:0003755|peptidyl-prolyl cis-trans isomerase activity|IEA; GO:0006457|protein folding|IEA; GO:0016853|isomerase activity|IEA

ACL00000105

unclassified

ACL00000106

CDC2

Cell division control protein 2 homolog related cluster

971

1e-104

63% (186/293)

2.7.1.37

Calcium signaling pathway

GO:0000910|cytokinesis|IEA; GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0007049|cell cycle|IEA; GO:0007067|mitosis|IEA; GO:0016740|transferase activity|IEA

ACL00000107

unclassified

ACL00000108

unclassified

ACL00000109

Inosine-5-monophosphate dehydrogenase related protein related cluster

205

1e-15

34% (47/136)

ACL00000110

Hydrolase, isochorismatase family related cluster

324

3e-29

42% (75/178)

GO:0003824|catalytic activity|IEA; GO:0008152|metabolism|IEA

ACL00000112

ATEM1.5; metallopeptidase M24 family protein

413

1e-39

47% (81/169)

ACL00000113

Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C related cluster

188

1e-13

39% (37/94)

6.3.5.-

Translation, ribosomal structure and biogenesis

GO:0006412|protein biosynthesis|IEA; GO:0006450|regulation of translational fidelity|IEA; GO:0016874|ligase activity|IEA; GO:0017068|glutamyl-tRNA(Gln) amidotransferase activity|IEA

ACL00000114

Similar to Mus musculus (Mouse). similar to 60S ribosomal protein L30 isolog related cluster

504

4e-50

60% (90/149)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005634|nucleus|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0007046|ribosome biogenesis|IEA

ACL00000115

unclassified

ACL00000116

unclassified

ACL00000117

LOC56769

Putative nuclear protein related cluster

217

4e-17

39% (45/114)

GO:0005634|nucleus|IEA

ACL00000118

Rpl9

60S ribosomal protein L9 related cluster

524

2e-52

53% (102/190)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000119

Probable electron transfer flavoprotein, beta subunit related cluster

707

1e-73

58% (144/247)

Energy production and conversion

GO:0005489|electron transporter activity|IEA; GO:0006118|electron transport|IEA

ACL00000120

T17F15.100; hypoxia-responsive family protein / zinc finger (C3HC4-type RING finger) family protein

139

5e-08

52% (32/61)

ACL00000121

ETR1

Mitochondrial respiratory function protein homolog related cluster

139

1e-23

40% (30/75)

1.3.1.10

GO:0004024|alcohol dehydrogenase activity, zinc-dependent|IEA; GO:0004319|enoyl-[acyl-carrier protein] reductase (NADPH, B-specific) activity|IEA; GO:0005739|mitochondrion|IEA; GO:0006633|fatty acid biosynthesis|IEA; GO:0008270|zinc ion binding|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000122

unclassified

ACL00000123

Unassigned protein

119

8e-06

28% (41/145)

ACL00000124

Ribosomal protein L14-like protein related cluster

351

1e-32

53% (72/135)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000125

RNA polymerase II subunit 5-mediating protein related cluster

208

2e-16

42% (42/98)

GO:0003714|transcription corepressor activity|TAS; GO:0005515|protein binding|IEA; GO:0005634|nucleus|IEA; GO:0005634|nucleus|TAS; GO:0005665|DNA-directed RNA polymerase II, core complex|TAS; GO:0005737|cytoplasm|TAS; GO:0006357|regulation of transcription from Pol II promoter|TAS; GO:0006457|protein folding|IEA; GO:0009615|response to virus|TAS; GO:0016272|prefoldin complex|IEA

ACL00000126

Ras-related protein Rap-1 related cluster

603

1e-61

73% (121/164)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00000127

translocon-associated protein gamma [Branchiostoma belcheri tsingtaunese]

126

5e-06

24% (35/144)

ACL00000128

unclassified

ACL00000129

multi-domain protein

152

1e-10

27% (49/178)

ACL00000131

unclassified

ACL00000132

rnhA

Ribonuclease H related cluster

169

2e-11

49% (30/61)

GO:0003676|nucleic acid binding|IEA; GO:0004523|ribonuclease H activity|IEA

ACL00000133

Keratin_B2 domain containing protein

111

8e-06

21% (18/83)

ACL00000136

Mapk7

MAP kinase related cluster

298

2e-26

38% (71/185)

2.7.1.37

MAPK signaling pathway

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0004707|MAP kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00000137

NADPH:quinone reductase related cluster

455

2e-44

45% (95/211)

1.6.5.5

GO:0003960|NADPH:quinone reductase activity|IEA; GO:0004024|alcohol dehydrogenase activity, zinc-dependent|IEA; GO:0008270|zinc ion binding|IEA

ACL00000138

HESB like domain containing 2 [Homo sapiens] gb|AAG59854.1| GK004 [Homo sapiens]

310

1e-27

48% (64/133)

ACL00000139

multi-domain protein

112

4e-06

25% (55/217)

ACL00000140

CISY

Citrate synthase, mitochondrial precursor related cluster

803

8e-85

72% (149/206)

2.3.3.1

Energy production and conversion

Citrate cycle (TCA cycle) Glyoxylate and dicarboxylate metabolism

GO:0004108|citrate (Si)-synthase activity|IEA; GO:0004108|citrate (Si)-synthase activity|TAS; GO:0005737|cytoplasm|IEA; GO:0005739|mitochondrion|IEA; GO:0005739|mitochondrion|TAS; GO:0006092|main pathways of carbohydrate metabolism|IEA; GO:0006099|tricarboxylic acid cycle|IEA; GO:0016740|transferase activity|IEA; GO:0046912|transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer|IEA

ACL00000141

PPR-repeat protein related cluster

150

3e-09

27% (49/181)

GO:0005488|binding|IEA

ACL00000142

unclassified

ACL00000143

Unassigned protein

ACL00000144

Bat1a

Nuclear RNA helicase BAT1 related cluster

1347

1e-147

61% (262/425)

GO:0003676|nucleic acid binding|IEA; GO:0004386|helicase activity|IEA; GO:0005524|ATP binding|IEA; GO:0008026|ATP-dependent helicase activity|IEA

ACL00000145

Herpes_gp2 domain containing protein

116

2e-06

26% (49/185)

ACL00000146

YbaK/EbsC protein

366

3e-34

46% (81/176)

ACL00000147

Similar to Homo sapiens (Human). vacuolar proton pump delta polypeptide related cluster

412

1e-39

64% (83/128)

Energy production and conversion

GO:0015986|ATP synthesis coupled proton transport|IEA; GO:0016469|proton-transporting two-sector ATPase complex|IEA; GO:0046933|hydrogen-transporting ATP synthase activity, rotational mechanism|IEA; GO:0046961|hydrogen-transporting ATPase activity, rotational mechanism|IEA

ACL00000148

DnaJ domain containing protein

124

1e-07

46% (20/43)

ACL00000150

DM6 domain containing protein

89

9e-05

24% (29/117)

ACL00000151

Efhd2

EF-hand domain-containing protein 2 related cluster

367

2e-34

50% (79/157)

GO:0005509|calcium ion binding|IEA

ACL00000152

adhC

Alcohol dehydrogenase class III related cluster

627

2e-64

72% (112/155)

1.2.1.1 1.1.1.1

Energy production and conversion

Bile acid biosynthesis Fatty acid metabolism Glycerolipid metabolism Glycolysis / Gluconeogenesis Methane metabolism Pyruvate metabolism Tyrosine metabolism

GO:0004022|alcohol dehydrogenase activity|IEA; GO:0004024|alcohol dehydrogenase activity, zinc-dependent|IEA; GO:0008270|zinc ion binding|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000153

elovl6

Fatty acyl elongase related cluster

427

5e-41

37% (89/235)

GO:0016021|integral to membrane|IEA; GO:0016021|integral to membrane|TAS; GO:0016747|transferase activity, transferring groups other than amino-acyl groups|IDA; GO:0030176|integral to endoplasmic reticulum membrane|IDA; GO:0030497|fatty acid elongation|IDA

ACL00000154

multi-domain protein

124

3e-07

21% (71/335)

ACL00000155

Ubiquitin-conjugating enzyme E2 related cluster

629

9e-65

70% (109/154)

6.3.2.19

Posttranslational modification, protein turnover, chaperones

GO:0004840|ubiquitin conjugating enzyme activity|IEA; GO:0004842|ubiquitin-protein ligase activity|IEA; GO:0006464|protein modification|IEA; GO:0006512|ubiquitin cycle|IEA; GO:0016874|ligase activity|IEA

ACL00000156

Naca

NASCENT polypeptide associated complex alpha subunit related cluster

420

1e-40

51% (93/182)

Transcription

GO:0005737|cytoplasm|TAS; GO:0005854|nascent polypeptide-associated complex|TAS; GO:0006412|protein biosynthesis|TAS; GO:0006444|nascent polypeptide association|TAS

ACL00000157

Unassigned protein

ACL00000158

SET domain protein 123 related cluster

247

3e-20

25% (79/314)

General function prediction only

ACL00000159

unclassified

ACL00000161

CPXB

Bifunctional P-450:NADPH-P450 reductase related cluster

273

2e-23

41% (65/155)

1.14.14.1

Inorganic ion transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0003958|NADPH-hemoprotein reductase activity|IEA; GO:0004497|monooxygenase activity|IEA; GO:0005489|electron transporter activity|IEA; GO:0006118|electron transport|IEA; GO:0010181|FMN binding|IEA; GO:0016020|membrane|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0050381|unspecific monooxygenase activity|IEA

ACL00000162

Unassigned protein

ACL00000163

Guanylate cyclase-activating protein 3 related cluster

194

3e-14

36% (41/113)

GO:0005509|calcium ion binding|IEA

ACL00000165

unclassified

ACL00000166

UBX domain containing protein

94

2e-05

18% (15/80)

ACL00000167

Coactosin related cluster

320

9e-29

45% (67/146)

GO:0003779|actin binding|IEA; GO:0005622|intracellular|IEA; GO:0005856|cytoskeleton|IEA

ACL00000168

Unknown EST

86

3e-11

29% (13/44)

ACL00000169

CG3320

Ras-related protein Rab-1A related cluster

659

4e-68

71% (121/170)

GO:0005525|GTP binding|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0005794|Golgi apparatus|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00000170

unclassified

ACL00000171

F8K7.20; F-box family protein

128

9e-07

46% (23/49)

ACL00000172

Ras-related protein Rab7 related cluster

394

1e-83

91% (75/82)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00000173

ZnF_ZZ domain containing protein

113

7e-08

36% (16/44)

ACL00000174

unclassified

ACL00000175

unclassified

ACL00000176

Adenylate kinase related cluster

683

9e-71

60% (134/221)

2.7.4.3

Nucleotide transport and metabolism

Purine metabolism

GO:0004017|adenylate kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA; GO:0016776|phosphotransferase activity, phosphate group as acceptor|IEA

ACL00000177

unclassified

ACL00000179

DAPT

Dihydroxyacetone phosphate acyltransferase related cluster

195

6e-14

24% (107/437)

2.3.1.42

Lipid transport and metabolism

Glycerolipid metabolism

GO:0003824|catalytic activity|IDA; GO:0005777|peroxisome|IEA; GO:0005782|peroxisomal matrix|TAS; GO:0008152|metabolism|IEA; GO:0008415|acyltransferase activity|IEA; GO:0008611|ether lipid biosynthesis|IMP; GO:0016020|membrane|IEA; GO:0016044|membrane organization and biogenesis|IMP; GO:0016287|glycerone-phosphate O-acyltransferase activity|IDA; GO:0016287|glycerone-phosphate O-acyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00000181

5'-AMP-activated protein kinase, gamma-2 subunit related cluster

163

2e-10

19% (80/403)

GO:0005554|molecular_function unknown|ND; GO:0006633|fatty acid biosynthesis|IEA; GO:0006695|cholesterol biosynthesis|NAS; GO:0008372|cellular_component unknown|ND

ACL00000182

Putative transmembrane protein related cluster

147

3e-09

42% (35/82)

GO:0008152|metabolism|IEA; GO:0016021|integral to membrane|IEA

ACL00000183

unclassified

ACL00000184

Epoxidase subunit A related cluster

308

1e-27

43% (64/146)

ACL00000185

Unknown EST

49

6e-08

43% (13/30)

ACL00000186

PA domain containing protein

115

2e-06

26% (18/67)

ACL00000188

Putative mRNA capping enzyme subunit related cluster

217

1e-16

30% (67/217)

GO:0004651|polynucleotide 5'-phosphatase activity|IEA; GO:0005634|nucleus|IEA; GO:0006370|mRNA capping|IEA; GO:0016787|hydrolase activity|IEA

ACL00000191

T17F3.17; CBS domain-containing protein

163

1e-10

26% (60/225)

General function prediction only

ACL00000192

Polyubiquitin related cluster

748

2e-78

86% (152/176)

ACL00000193

Herpes_UL56 domain containing protein

110

7e-06

25% (37/145)

ACL00000194

Histone H3 related cluster

445

2e-43

69% (94/135)

Chromatin structure and dynamics

GO:0000786|nucleosome|IEA; GO:0003677|DNA binding|IEA; GO:0005634|nucleus|IEA; GO:0005694|chromosome|IEA; GO:0006334|nucleosome assembly|IEA; GO:0007001|chromosome organization and biogenesis (sensu Eukaryota)|IEA

ACL00000195

unclassified

ACL00000196

AFR526Cp

AFR526Cp; syntenic homolog of Saccharomyces cerevisiae YOR298C-A (MBF1) [KO:K03627]

204

1e-15

53% (44/83)

Transcription

ACL00000198

CPDc domain containing protein

103

1e-06

35% (23/65)

ACL00000200

fusA

Elongation factor G, mitochondrial precursor related cluster

504

3e-50

51% (108/210)

3.6.5.3

Translation, ribosomal structure and biogenesis

GO:0003746|translation elongation factor activity|IEA; GO:0005525|GTP binding|IEA; GO:0005739|mitochondrion|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006414|translational elongation|IEA

ACL00000201

unclassified

ACL00000202

Prohibitin related cluster

682

1e-70

54% (136/248)

Posttranslational modification, protein turnover, chaperones

GO:0001302|replicative cell aging|IMP; GO:0005739|mitochondrion|IDA; GO:0005743|mitochondrial inner membrane|TAS; GO:0006508|proteolysis and peptidolysis|IMP

ACL00000203

unclassified

ACL00000204

Enoyl CoA hydratase-like protein related cluster

478

3e-47

44% (101/229)

Lipid transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0008152|metabolism|IEA

ACL00000205

multi-domain protein

127

7e-08

21% (33/157)

ACL00000206

EIF4EBP3

Eukaryotic translation initiation factor 4E binding protein 3 related cluster

219

3e-17

55% (44/80)

GO:0006417|regulation of protein biosynthesis|IEA; GO:0006445|regulation of translation|IEA; GO:0008190|eukaryotic initiation factor 4E binding|IEA; GO:0016281|eukaryotic translation initiation factor 4F complex|NAS; GO:0016478|negative regulation of translation|NAS; GO:0017148|negative regulation of protein biosynthesis|IEA; GO:0030371|translation repressor activity|NAS; GO:0045947|negative regulation of translational initiation|IEA

ACL00000207

thiH

ThiH protein related cluster

324

1e-29

42% (74/176)

GO:0003824|catalytic activity|IEA; GO:0005506|iron ion binding|IEA

ACL00000208

TT_ORF1 domain containing protein

111

4e-06

37% (35/93)

ACL00000209

MGC72590

MGC72590; similar to endoplasmic reticulum chaperone SIL1 homolog

243

8e-20

29% (70/240)

ACL00000211

unclassified

ACL00000212

MDHC

Malate dehydrogenase, cytoplasmic related cluster

405

4e-88

63% (82/130)

1.1.1.37

Energy production and conversion

GO:0006099|tricarboxylic acid cycle|IEA; GO:0006100|tricarboxylic acid cycle intermediate metabolism|IEA; GO:0006108|malate metabolism|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016615|malate dehydrogenase activity|IEA; GO:0030060|L-malate dehydrogenase activity|IEA

ACL00000213

RNA-binding protein precursor related cluster

212

2e-16

41% (41/100)

General function prediction only

GO:0003723|RNA binding|IEA

ACL00000214

ivd2

Putative isovaleryl-CoA dehydrogenase protein related cluster

309

2e-27

64% (57/88)

1.3.99.10

Lipid transport and metabolism

Valine, leucine and isoleucine degradation

GO:0003995|acyl-CoA dehydrogenase activity|IEA; GO:0006118|electron transport|IEA; GO:0008470|isovaleryl-CoA dehydrogenase activity|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000215

ivd2

Isovaleryl-CoA dehydrogenase related cluster

1105

1e-120

79% (210/265)

1.3.99.10

Lipid transport and metabolism

Valine, leucine and isoleucine degradation

GO:0003995|acyl-CoA dehydrogenase activity|IEA; GO:0006118|electron transport|IEA; GO:0008470|isovaleryl-CoA dehydrogenase activity|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000216

UGDH

UDP-glucose 6-dehydrogenase related cluster

577

1e-58

51% (112/217)

1.1.1.22

Cell wall/membrane/envelope biogenesis

Nucleotide sugars metabolism Pentose and glucuronate interconversions Starch and sucrose metabolism

GO:0003979|UDP-glucose 6-dehydrogenase activity|IEA; GO:0003979|UDP-glucose 6-dehydrogenase activity|TAS; GO:0006118|electron transport|IEA; GO:0007224|smoothened signaling pathway|TAS; GO:0007427|tracheal cell migration (sensu Insecta)|TAS; GO:0007428|primary tracheal branching (sensu Insecta)|TAS; GO:0007507|heart development|NAS; GO:0008543|fibroblast growth factor receptor signaling pathway|TAS; GO:0015012|heparan sulfate proteoglycan biosynthesis|TAS; GO:0015014|heparan sulfate proteoglycan biosynthesis, polysaccharide chain biosynthesis|NAS; GO:0016055|Wnt receptor signaling pathway|TAS; GO:0016491|oxidoreductase activity|IEA; GO:0030206|chondroitin sulfate biosynthesis|TAS

ACL00000218

PLAC8

Placenta-specific gene 8 protein related cluster

136

9e-08

33% (33/99)

ACL00000219

multi-domain protein

124

2e-07

23% (20/85)

ACL00000220

LOC385608

40S ribosomal protein S10 related cluster

267

1e-22

41% (58/140)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA

ACL00000222

Histone H4 related cluster

422

6e-41

96% (82/85)

Chromatin structure and dynamics

GO:0000786|nucleosome|IEA; GO:0003677|DNA binding|IEA; GO:0005634|nucleus|IEA; GO:0005694|chromosome|IEA; GO:0006334|nucleosome assembly|IEA; GO:0007001|chromosome organization and biogenesis (sensu Eukaryota)|IEA

ACL00000223

multi-domain protein

127

1e-07

19% (60/313)

ACL00000224

unclassified

ACL00000225

Unassigned protein

ACL00000226

FCAALL.203; fumarylacetoacetate hydrolase family protein

648

5e-67

64% (126/196)

ACL00000227

unclassified

ACL00000228

Calcium-dependent protein kinase, isoform 2 related cluster

182

5e-13

33% (56/165)

2.7.1.-

Benzoate degradation via CoA ligation Inositol phosphate metabolism Nicotinate and nicotinamide metabolism Starch and sucrose metabolism

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005509|calcium ion binding|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016740|transferase activity|IEA

ACL00000229

Translationally controlled tumor protein homolog related cluster

358

2e-33

42% (72/169)

GO:0005554|molecular_function unknown|IEA; GO:0005737|cytoplasm|IEA; GO:0006457|protein folding|IEA; GO:0051082|unfolded protein binding|IEA

ACL00000230

Penicillin binding protein related cluster

693

5e-72

68% (139/204)

2.4.2.-

Cell wall/membrane/envelope biogenesis

GO:0003824|catalytic activity|IEA; GO:0008658|penicillin binding|IEA; GO:0009252|peptidoglycan biosynthesis|IEA; GO:0009273|cell wall biosynthesis (sensu Bacteria)|IEA; GO:0009274|cell wall (sensu Bacteria)|IEA

ACL00000231

GPMA

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase related cluster

412

9e-94

80% (76/94)

5.4.2.1

Carbohydrate transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0004619|phosphoglycerate mutase activity|IEA; GO:0006096|glycolysis|IEA; GO:0008152|metabolism|IEA; GO:0016853|isomerase activity|IEA; GO:0016868|intramolecular transferase activity, phosphotransferases|IEA; GO:0046538|2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity|IEA

ACL00000232

Vesicle-associated membrane protein 712 related cluster

430

1e-41

40% (78/191)

GO:0006810|transport|IEA; GO:0015031|protein transport|IEA; GO:0016021|integral to membrane|IEA

ACL00000234

Rps27

40S ribosomal protein S27 related cluster

377

5e-36

83% (67/80)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003723|RNA binding|TAS; GO:0003735|structural constituent of ribosome|IEA; GO:0003735|structural constituent of ribosome|TAS; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0005843|cytosolic small ribosomal subunit (sensu Eukaryota)|TAS; GO:0006412|protein biosynthesis|IEA; GO:0006412|protein biosynthesis|TAS; GO:0007165|signal transduction|TAS; GO:0008270|zinc ion binding|TAS; GO:0008283|cell proliferation|TAS

ACL00000235

Putative GTP-binding protein related cluster

170

3e-33

46% (34/73)

General function prediction only

ACL00000236

hpt

Hypoxanthine-guanine phosphoribosyltransferase related cluster

419

2e-40

47% (78/165)

2.4.2.8

Nucleotide transport and metabolism

Purine metabolism

GO:0004422|hypoxanthine phosphoribosyltransferase activity|IEA; GO:0005737|cytoplasm|IEA; GO:0006166|purine ribonucleoside salvage|IEA; GO:0009116|nucleoside metabolism|IEA; GO:0016740|transferase activity|IEA; GO:0016757|transferase activity, transferring glycosyl groups|IEA

ACL00000237

Adenylosuccinate lyase related cluster

101

6e-64

43% (20/46)

Nucleotide transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0004018|adenylosuccinate lyase activity|IEA; GO:0009152|purine ribonucleotide biosynthesis|IEA; GO:0016829|lyase activity|IEA

ACL00000238

SYD

Aspartyl-tRNA synthetase related cluster

258

4e-22

42% (54/126)

6.1.1.12

Translation, ribosomal structure and biogenesis

Alanine and aspartate metabolism

GO:0003676|nucleic acid binding|IEA; GO:0004046|aminoacylase activity|TAS; GO:0004812|tRNA ligase activity|IEA; GO:0004815|aspartate-tRNA ligase activity|IEA; GO:0004815|aspartate-tRNA ligase activity|TAS; GO:0005524|ATP binding|IEA; GO:0005625|soluble fraction|TAS; GO:0005737|cytoplasm|IEA; GO:0005737|cytoplasm|TAS; GO:0006412|protein biosynthesis|IEA; GO:0006412|protein biosynthesis|TAS; GO:0006418|tRNA aminoacylation for protein translation|IEA; GO:0006422|aspartyl-tRNA aminoacylation|IEA; GO:0006422|aspartyl-tRNA aminoacylation|TAS; GO:0006461|protein complex assembly|TAS; GO:0016874|ligase activity|IEA

ACL00000239

F14P3.15; proteasome family protein

354

1e-32

31% (81/261)

ACL00000240

Co-chaperone GrpE, putative related cluster

345

1e-31

43% (69/160)

Posttranslational modification, protein turnover, chaperones

GO:0000774|adenyl-nucleotide exchange factor activity|IEA; GO:0005739|mitochondrion|IEA; GO:0006457|protein folding|IEA; GO:0042803|protein homodimerization activity|IEA; GO:0051082|unfolded protein binding|IEA; GO:0051087|chaperone binding|IEA

ACL00000241

DUF566 domain containing protein

110

6e-06

25% (42/162)

ACL00000242

Ribosomal protein L30 related cluster

476

2e-47

81% (91/112)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000245

SNF4

Nuclear protein SNF4 related cluster

264

4e-22

25% (83/322)

GO:0005634|nucleus|IDA; GO:0005634|nucleus|IEA; GO:0005737|cytoplasm|IDA; GO:0005886|plasma membrane|IDA; GO:0005975|carbohydrate metabolism|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006357|regulation of transcription from Pol II promoter|IGI; GO:0007031|peroxisome organization and biogenesis|IMP; GO:0030295|protein kinase activator activity|IGI

ACL00000247

Unassigned protein

ACL00000249

60S ribosomal protein L12 related cluster

544

8e-55

61% (102/167)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000250

Hgd

Homogentisate 1,2-dioxygenase related cluster

1515

1e-167

67% (286/426)

1.13.11.5

Secondary metabolites biosynthesis, transport and catabolism

Styrene degradation Tyrosine metabolism

GO:0004411|homogentisate 1,2-dioxygenase activity|IEA; GO:0006559|L-phenylalanine catabolism|IEA; GO:0006570|tyrosine metabolism|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016702|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|IEA

ACL00000251

Probable small nuclear ribonucleoprotein F related cluster

344

6e-32

72% (63/87)

Transcription

GO:0000398|nuclear mRNA splicing, via spliceosome|IEA; GO:0003723|RNA binding|IEA; GO:0005634|nucleus|IEA; GO:0005732|small nucleolar ribonucleoprotein complex|IEA; GO:0006397|mRNA processing|IEA; GO:0008248|pre-mRNA splicing factor activity|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00000254

Rps7

40S ribosomal protein S7 related cluster

578

9e-59

61% (117/190)

Ribosome

GO:0003723|RNA binding|TAS; GO:0003735|structural constituent of ribosome|TAS; GO:0005843|cytosolic small ribosomal subunit (sensu Eukaryota)|TAS; GO:0006412|protein biosynthesis|TAS

ACL00000255

COP-coated vesicle membrane protein P24 homolog related cluster

243

8e-20

34% (56/162)

GO:0006886|intracellular protein transport|IEA; GO:0008320|protein carrier activity|IEA; GO:0016020|membrane|IEA

ACL00000257

[T] COG0589 Universal stress protein UspA and related nucleotide-binding proteins

157

1e-10

35% (32/89)

Signal transduction mechanisms

ACL00000258

CBS domain protein related cluster

182

1e-12

23% (58/252)

General function prediction only

ACL00000259

C-24(28) sterol reductase, putative related cluster

281

7e-25

69% (46/66)

GO:0016020|membrane|IEA

ACL00000260

Peroxidase ppod2 related cluster

122

4e-06

32% (38/117)

GO:0004601|peroxidase activity|IEA

ACL00000262

multi-domain protein

116

2e-06

46% (27/58)

ACL00000263

Small GTP binding protein RAB6, putative related cluster

164

5e-11

31% (46/146)

General function prediction only

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00000264

Ranbp1

Ran-specific GTPase-activating protein related cluster

396

1e-37

63% (76/119)

Intracellular trafficking, secretion, and vesicular transport

GO:0005092|GDP-dissociation inhibitor activity|TAS; GO:0005096|GTPase activator activity|IEA; GO:0007165|signal transduction|TAS; GO:0008536|RAN protein binding|TAS

ACL00000265

VATB

Vacuolar ATP synthase subunit B related cluster

442

0.0

77% (88/114)

3.6.3.14

Energy production and conversion

ATP synthesis Oxidative phosphorylation

GO:0005524|ATP binding|IEA; GO:0005737|cytoplasm|IEA; GO:0006754|ATP biosynthesis|IEA; GO:0008553|hydrogen-exporting ATPase activity, phosphorylative mechanism|IEA; GO:0015078|hydrogen ion transporter activity|IEA; GO:0015986|ATP synthesis coupled proton transport|IEA; GO:0015988|energy coupled proton transport, against electrochemical gradient|IEA; GO:0015992|proton transport|IEA; GO:0016469|proton-transporting two-sector ATPase complex|IEA; GO:0016787|hydrolase activity|IEA; GO:0046933|hydrogen-transporting ATP synthase activity, rotational mechanism|IEA; GO:0046961|hydrogen-transporting ATPase activity, rotational mechanism|IEA

ACL00000266

Ribosomal protein S18 related cluster

585

1e-59

70% (107/151)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003723|RNA binding|IEA; GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00000267

multi-domain protein

128

8e-08

22% (56/253)

ACL00000268

EIF3S7

Eukaryotic translation initiation factor 3 subunit 7 related cluster

945

1e-101

48% (191/395)

GO:0003743|translation initiation factor activity|IEA; GO:0003743|translation initiation factor activity|TAS; GO:0005852|eukaryotic translation initiation factor 3 complex|TAS; GO:0006412|protein biosynthesis|IEA; GO:0006413|translational initiation|IEA; GO:0006446|regulation of translational initiation|TAS

ACL00000270

Membrane associated progesterone receptor component 1 related cluster

147

8e-09

26% (38/141)

GO:0004872|receptor activity|IEA; GO:0005496|steroid binding|IEA; GO:0005496|steroid binding|TAS; GO:0005792|microsome|IEA; GO:0005887|integral to plasma membrane|TAS; GO:0016021|integral to membrane|IEA

ACL00000271

60S acidic ribosomal protein P1 related cluster

127

1e-06

43% (27/62)

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006414|translational elongation|IEA

ACL00000273

MYLK

Myosin light chain kinase related cluster

965

1e-103

70% (183/260)

2.7.1.117

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0004687|myosin-light-chain kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016740|transferase activity|IEA

ACL00000274

Rpl24

60S ribosomal protein L24 related cluster

279

6e-24

55% (54/98)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003723|RNA binding|ISS; GO:0003735|structural constituent of ribosome|IEA; GO:0003735|structural constituent of ribosome|ISS; GO:0005622|intracellular|IEA; GO:0005737|cytoplasm|ISS; GO:0005840|ribosome|IEA; GO:0005842|cytosolic large ribosomal subunit (sensu Eukaryota)|ISS; GO:0006412|protein biosynthesis|IEA; GO:0006412|protein biosynthesis|ISS

ACL00000275

40S ribosomal protein S15A related cluster

544

5e-55

81% (105/129)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000276

Unknown EST

81

3e-09

36% (12/33)

ACL00000279

Ribosomal protein S29-like related cluster

235

2e-19

69% (39/56)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000280

Dihydropteridine reductase related cluster

601

2e-61

55% (125/224)

GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000281

UbcB related cluster

503

3e-50

64% (95/148)

GO:0004840|ubiquitin conjugating enzyme activity|IEA; GO:0006464|protein modification|IEA; GO:0006512|ubiquitin cycle|IEA

ACL00000282

multi-domain protein

126

1e-07

28% (26/92)

ACL00000284

Universal stress protein family related cluster

133

1e-07

49% (26/53)

Signal transduction mechanisms

GO:0006950|response to stress|IEA

ACL00000286

BCAS2

BCAS2; breast carcinoma amplified sequence 2

224

1e-17

28% (51/182)

ACL00000288

40S ribosomal protein S19-3 related cluster

515

1e-51

69% (94/136)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000289

PSMD8

26S proteasome regulatory particle non-ATPase subunit12 related cluster

462

3e-45

41% (101/245)

Proteasome

GO:0005829|cytosol|IEA; GO:0005838|proteasome regulatory particle (sensu Eukaryota)|IEA; GO:0006508|proteolysis and peptidolysis|IEA

ACL00000290

F14P22.40; universal stress protein (USP) family protein

177

2e-12

53% (33/62)

Signal transduction mechanisms

ACL00000291

unclassified

ACL00000294

Putative dehydrogenase related cluster

868

6e-92

53% (176/326)

1.1.1.28

Pyruvate metabolism

GO:0006564|L-serine biosynthesis|IEA; GO:0016616|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|IEA

ACL00000295

Eef1b2

Elongation factor 1-beta related cluster

366

5e-34

37% (83/224)

Translation, ribosomal structure and biogenesis

GO:0003746|translation elongation factor activity|IEA; GO:0003746|translation elongation factor activity|NAS; GO:0005853|eukaryotic translation elongation factor 1 complex|IEA; GO:0005853|eukaryotic translation elongation factor 1 complex|NAS; GO:0006412|protein biosynthesis|IEA; GO:0006414|translational elongation|IEA; GO:0006414|translational elongation|NAS

ACL00000296

COX5

Cytochrome c oxidase polypeptide V related cluster

186

2e-13

54% (34/62)

1.9.3.1

Oxidative phosphorylation

GO:0004129|cytochrome-c oxidase activity|IEA; GO:0005739|mitochondrion|IEA; GO:0005740|mitochondrial membrane|IEA; GO:0006118|electron transport|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0019866|inner membrane|IEA

ACL00000297

multi-domain protein

122

4e-07

16% (48/283)

ACL00000298

60S ribosomal protein L6 related cluster

211

1e-45

43% (48/110)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000299

Copper chaperone related cluster

147

3e-09

46% (27/58)

GO:0030001|metal ion transport|IEA; GO:0046872|metal ion binding|IEA

ACL00000300

LOC147346

60S ribosomal protein L7a related cluster

719

7e-75

64% (141/220)

Translation, ribosomal structure and biogenesis

GO:0003723|RNA binding|TAS; GO:0003735|structural constituent of ribosome|TAS; GO:0005842|cytosolic large ribosomal subunit (sensu Eukaryota)|TAS; GO:0006412|protein biosynthesis|TAS

ACL00000301

multi-domain protein

187

1e-14

21% (83/393)

ACL00000302

Elongation factor EF-2 related cluster

466

1e-45

41% (115/274)

Translation, ribosomal structure and biogenesis

GO:0003746|translation elongation factor activity|IEA; GO:0005525|GTP binding|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006414|translational elongation|IEA

ACL00000303

PROC1

Pyrroline-5-carboxylate reductase related cluster

627

3e-64

51% (134/262)

1.5.1.2

Amino acid transport and metabolism

Arginine and proline metabolism Urea cycle and metabolism of amino groups

GO:0004735|pyrroline-5-carboxylate reductase activity|IEA; GO:0006561|proline biosynthesis|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000306

RAB32

Ras-related protein Rab-32 related cluster

564

5e-57

49% (112/227)

GO:0005525|GTP binding|IEA; GO:0005739|mitochondrion|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00000309

LOC268695

Ribosomal protein L27a related cluster

585

9e-60

71% (107/149)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00000310

unclassified

ACL00000312

multi-domain protein

126

1e-07

25% (49/190)

ACL00000313

Rpl32

60S ribosomal protein L32 related cluster

418

2e-40

67% (75/111)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003723|RNA binding|NR; GO:0003735|structural constituent of ribosome|NR; GO:0005842|cytosolic large ribosomal subunit (sensu Eukaryota)|NR

ACL00000314

RPL5

60S ribosomal protein L5 related cluster

870

2e-92

58% (174/298)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003723|RNA binding|TAS; GO:0003735|structural constituent of ribosome|IEA; GO:0003735|structural constituent of ribosome|TAS; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0005842|cytosolic large ribosomal subunit (sensu Eukaryota)|TAS; GO:0006412|protein biosynthesis|IEA; GO:0006412|protein biosynthesis|TAS; GO:0008097|5S rRNA binding|IEA; GO:0019843|rRNA binding|IEA

ACL00000315

DUF566 domain containing protein

111

5e-06

16% (29/174)

ACL00000318

CBS domain protein related cluster

171

3e-11

22% (71/317)

General function prediction only

ACL00000320

ATPG

ATP synthase gamma chain, mitochondrial precursor related cluster

433

1e-41

38% (104/271)

3.6.3.14

Energy production and conversion

ATP synthesis Oxidative phosphorylation

GO:0005739|mitochondrion|IEA; GO:0006754|ATP biosynthesis|IEA; GO:0015078|hydrogen ion transporter activity|IEA; GO:0015986|ATP synthesis coupled proton transport|IEA; GO:0015992|proton transport|IEA; GO:0016020|membrane|IEA; GO:0016469|proton-transporting two-sector ATPase complex|IEA; GO:0016787|hydrolase activity|IEA; GO:0046933|hydrogen-transporting ATP synthase activity, rotational mechanism|IEA; GO:0046961|hydrogen-transporting ATPase activity, rotational mechanism|IEA

ACL00000321

unclassified

ACL00000322

Rps11

40S ribosomal protein S11 related cluster

576

1e-58

67% (110/164)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00000325

ylbB

YLBB protein related cluster

206

8e-16

37% (51/136)

ACL00000328

Rps27

40S ribosomal protein S27 related cluster

377

7e-36

83% (67/80)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003723|RNA binding|TAS; GO:0003735|structural constituent of ribosome|IEA; GO:0003735|structural constituent of ribosome|TAS; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0005843|cytosolic small ribosomal subunit (sensu Eukaryota)|TAS; GO:0006412|protein biosynthesis|IEA; GO:0006412|protein biosynthesis|TAS; GO:0007165|signal transduction|TAS; GO:0008270|zinc ion binding|TAS; GO:0008283|cell proliferation|TAS

ACL00000329

DUF566 domain containing protein

117

9e-07

26% (36/136)

ACL00000330

40S ribosomal protein, contains C-terminal domain related cluster

777

1e-81

69% (155/222)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003676|nucleic acid binding|IEA; GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0015935|small ribosomal subunit|IEA

ACL00000331

Iron/ascorbate oxidoreductase related cluster

169

5e-11

24% (74/299)

GO:0016491|oxidoreductase activity|IEA

ACL00000333

Profilins IA/IB related cluster

635

3e-65

100% (125/125)

ACL00000344

Gapd

Glyceraldehyde-3-phosphate dehydrogenase related cluster

59

1e-114

78% (11/14)

1.2.1.12

Carbohydrate transport and metabolism

Alzheimer's disease Dentatorubropallidoluysian atrophy (DRPLA) Glycolysis / Gluconeogenesis Huntington's disease Neurodegenerative Disorders

GO:0004365|glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity|IEA; GO:0006006|glucose metabolism|IEA; GO:0006096|glycolysis|IEA; GO:0008943|glyceraldehyde-3-phosphate dehydrogenase activity|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000346

ADP,ATP carrier protein 1, mitochondrial precursor related cluster

1181

1e-128

74% (225/302)

GO:0005215|transporter activity|IEA; GO:0005488|binding|IEA; GO:0005739|mitochondrion|IEA; GO:0005743|mitochondrial inner membrane|IEA; GO:0006810|transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0019866|inner membrane|IEA

ACL00000347

Ribosomal protein S8 related cluster

557

3e-56

50% (121/239)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00000350

PIP

Probable proline iminopeptidase related cluster

958

1e-102

57% (177/308)

3.4.11.5

Arginine and proline metabolism

GO:0003824|catalytic activity|IEA; GO:0004177|aminopeptidase activity|IEA; GO:0005737|cytoplasm|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0006725|aromatic compound metabolism|IEA; GO:0016787|hydrolase activity|IEA; GO:0016804|prolyl aminopeptidase activity|IEA

ACL00000351

unclassified

ACL00000352

unclassified

ACL00000353

rhtB

RhtB family transporter related cluster

360

8e-34

63% (70/110)

GO:0005293|lysine permease activity|IEA; GO:0006865|amino acid transport|IEA; GO:0016020|membrane|IEA

ACL00000354

Unassigned protein

ACL00000355

unclassified

ACL00000356

unclassified

ACL00000359

ctpD

Pilus assembly protein related cluster

710

3e-74

73% (145/198)

Type II secretion system

GO:0009306|protein secretion|IEA; GO:0016020|membrane|IEA

ACL00000360

ctpD

Pilus assembly protein related cluster

293

3e-26

68% (65/95)

Type II secretion system

GO:0009306|protein secretion|IEA; GO:0016020|membrane|IEA

ACL00000361

unclassified

ACL00000362

Unassigned protein

ACL00000363

aco2

Aconitase related cluster

117

7e-06

50% (25/50)

GO:0003994|aconitate hydratase activity|IEA; GO:0005739|mitochondrion|IEA; GO:0006099|tricarboxylic acid cycle|IEA; GO:0008152|metabolism|IEA; GO:0016829|lyase activity|IEA; GO:0016836|hydro-lyase activity|IEA

ACL00000364

ACON

Aconitate hydratase, mitochondrial precursor related cluster

476

2e-47

71% (86/121)

4.2.1.3

GO:0003994|aconitate hydratase activity|IEA; GO:0005739|mitochondrion|IEA; GO:0006099|tricarboxylic acid cycle|IEA; GO:0008152|metabolism|IEA; GO:0016829|lyase activity|IEA; GO:0016836|hydro-lyase activity|IEA

ACL00000365

unclassified

ACL00000366

unclassified

ACL00000368

P_proprotein domain containing protein

128

1e-08

42% (27/64)

ACL00000369

unclassified

ACL00000370

unclassified

ACL00000371

kup1

Kup related cluster

751

4e-79

89% (149/167)

GO:0006810|transport|IEA; GO:0006813|potassium ion transport|IEA; GO:0015079|potassium ion transporter activity|IEA; GO:0015293|symporter activity|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0019866|inner membrane|IEA

ACL00000372

ATP synthase, subunit I related cluster

341

1e-31

64% (67/104)

ACL00000373

30 kDa heat shock protein related cluster

183

9e-13

31% (44/139)

Posttranslational modification, protein turnover, chaperones

GO:0006457|protein folding|IEA; GO:0006986|response to unfolded protein|IEA

ACL00000374

Histidinol-phosphate aminotransferase-like protein related cluster

90

3e-09

32% (17/53)

2.6.1.9

Histidine metabolism Novobiocin biosynthesis Phenylalanine metabolism Phenylalanine, tyrosine and tryptophan biosynthesis Tyrosine metabolism

ACL00000375

HIS7

Imidazoleglycerol-phosphate dehydratase related cluster

211

1e-16

44% (51/115)

4.2.1.19

GO:0000105|histidine biosynthesis|IEA; GO:0003824|catalytic activity|IEA; GO:0004401|histidinol-phosphatase activity|IEA; GO:0004424|imidazoleglycerol-phosphate dehydratase activity|IEA; GO:0008152|metabolism|IEA; GO:0016829|lyase activity|IEA

ACL00000376

CG5193

Transcription initiation factor IIB related cluster

317

3e-28

29% (81/274)

Transcription

Basal transcription factors

GO:0003702|RNA polymerase II transcription factor activity|IEA; GO:0005634|nucleus|IEA; GO:0005667|transcription factor complex|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006367|transcription initiation from Pol II promoter|IEA

ACL00000377

unclassified

ACL00000379

ATP-dependent DNA helicase II, 70 kDa subunit related cluster

237

9e-20

41% (49/117)

GO:0003677|DNA binding|IEA; GO:0003690|double-stranded DNA binding|TAS; GO:0004003|ATP-dependent DNA helicase activity|IEA; GO:0004003|ATP-dependent DNA helicase activity|TAS; GO:0004386|helicase activity|IEA; GO:0005624|membrane fraction|TAS; GO:0005634|nucleus|IEA; GO:0005634|nucleus|TAS; GO:0006266|DNA ligation|TAS; GO:0006281|DNA repair|IEA; GO:0006303|double-strand break repair via nonhomologous end-joining|IEA; GO:0006303|double-strand break repair via nonhomologous end-joining|TAS; GO:0006310|DNA recombination|IEA; GO:0006310|DNA recombination|NR

ACL00000380

unclassified

ACL00000382

Protein kinase Npk related cluster

191

2e-14

41% (36/86)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0004713|protein-tyrosine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00000384

Unassigned protein

ACL00000385

zgc:66108

Similar to growth hormone inducible transmembrane protein related cluster

227

1e-17

27% (61/224)

ACL00000387

unclassified

ACL00000388

LIM domain containing protein

89

5e-05

48% (14/29)

ACL00000389

Vesicle transport v-SNARE 11 related cluster

183

4e-13

26% (46/171)

GO:0005794|Golgi apparatus|IEA; GO:0006810|transport|IEA; GO:0006886|intracellular protein transport|IEA; GO:0015031|protein transport|IEA; GO:0016021|integral to membrane|IEA

ACL00000390

Histidine kinase DhkJ related cluster

429

5e-42

66% (85/127)

Signal transduction mechanisms

GO:0000155|two-component sensor molecule activity|IEA; GO:0000156|two-component response regulator activity|IEA; GO:0000160|two-component signal transduction system (phosphorelay)|IEA; GO:0003677|DNA binding|IEA; GO:0004871|signal transducer activity|IEA; GO:0005524|ATP binding|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0007165|signal transduction|IEA; GO:0007600|sensory perception|IEA; GO:0016020|membrane|IEA; GO:0016301|kinase activity|IEA; GO:0016310|phosphorylation|IEA; GO:0016772|transferase activity, transferring phosphorus-containing groups|IEA

ACL00000392

SMPDL3A

Acid sphingomyelinase-like phosphodiesterase 3a precursor related cluster

473

3e-46

31% (124/395)

GO:0000004|biological_process unknown|ND; GO:0005515|protein binding|IPI; GO:0005576|extracellular region|NR; GO:0005975|carbohydrate metabolism|IEA; GO:0016787|hydrolase activity|IEA; GO:0016798|hydrolase activity, acting on glycosyl bonds|IEA

ACL00000393

Unknown EST

228

1e-21

46% (49/106)

ACL00000395

SAHH

Adenosylhomocysteinase related cluster

356

1e-179

72% (67/92)

3.3.1.1

Methionine metabolism Selenoamino acid metabolism

GO:0004013|adenosylhomocysteinase activity|IEA; GO:0006730|one-carbon compound metabolism|IEA; GO:0016787|hydrolase activity|IEA

ACL00000396

unclassified

ACL00000397

Similar to Dictyostelium discoideum (Slime mold). homeobox-containing protein related cluster

120

4e-06

46% (22/47)

GO:0003723|RNA binding|IEA; GO:0005634|nucleus|IEA

ACL00000398

Herpes_gp2 domain containing protein

111

5e-06

30% (39/127)

ACL00000399

Short chain dehydrogenase related cluster

217

2e-17

56% (44/78)

GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000400

Short chain dehydrogenase family protein related cluster

270

1e-23

48% (53/110)

GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000401

Nuclear transport factor 2 related cluster

344

8e-32

56% (69/123)

GO:0005622|intracellular|IEA; GO:0005634|nucleus|IEA; GO:0006606|protein-nucleus import|IEA; GO:0006810|transport|IEA; GO:0008565|protein transporter activity|IEA; GO:0015031|protein transport|IEA

ACL00000402

Unassigned protein

ACL00000404

unclassified

ACL00000405

Mito_carr domain containing protein

109

3e-06

34% (29/83)

ACL00000407

PHOX

Potential acid phosphatase related cluster

506

4e-50

40% (107/265)

3.1.3.2

GO:0003993|acid phosphatase activity|IEA; GO:0016787|hydrolase activity|IEA; GO:0016788|hydrolase activity, acting on ester bonds|IEA

ACL00000408

Herpes_gp2 domain containing protein

119

5e-07

26% (37/141)

ACL00000409

multi-domain protein

146

4e-10

50% (33/66)

ACL00000410

Golga7

Golga7; golgi autoantigen, golgin subfamily a, 7

235

2e-19

36% (39/106)

ACL00000411

AGR284Wp

AGR284Wp; syntenic homolog of Saccharomyces cerevisiae YLR285W

266

6e-23

40% (54/135)

ACL00000412

L8003.8 gene product

157

1e-10

40% (37/91)

ACL00000413

Putative requirement for the function of snoRNPs by similarity to human nop10, direct rRNA pseudouridinylation related cluster

242

2e-20

70% (45/64)

GO:0005634|nucleus|IEA; GO:0007046|ribosome biogenesis|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00000414

Beta-lactamase domain containing protein

114

1e-06

28% (23/81)

ACL00000415

D-alanyl-D-alanine carboxypeptidease, putative related cluster

137

4e-08

30% (30/98)

GO:0046677|response to antibiotic|IEA

ACL00000417

unclassified

ACL00000418

HSD17B12

Putative steroid dehydrogenase SPM2 related cluster

552

1e-55

44% (119/269)

1.1.1.-

General function prediction only

Ascorbate and aldarate metabolism Benzoate degradation via CoA ligation Bile acid biosynthesis Butanoate metabolism Fructose and mannose metabolism Galactose metabolism Glycerolipid metabolism Glycine, serine and threonine metabolism Lysine degradation Nucleotide sugars metabolism Tetrachloroethene degradation

GO:0006694|steroid biosynthesis|IEA; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000419

Unknown EST

116

6e-06

43% (22/51)

ACL00000420

unclassified

ACL00000421

rab2

Ras-related protein Rab-2A related cluster

743

7e-78

78% (139/177)

GO:0005525|GTP binding|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0005794|Golgi apparatus|IEA; GO:0006810|transport|IEA; GO:0006886|intracellular protein transport|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00000422

unclassified

ACL00000423

AER450Cp

Probable phosphate transport protein MIR1 related cluster

649

9e-67

48% (140/288)

GO:0005488|binding|IEA; GO:0005743|mitochondrial inner membrane|IEA; GO:0006810|transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA

ACL00000424

unclassified

ACL00000425

Putative 40S ribosomal protein S24 related cluster

468

7e-46

72% (86/118)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000426

kbl

2-amino-3-ketobutyrate CoA ligase related cluster

160

2e-36

70% (31/44)

2.3.1.29

Coenzyme transport and metabolism

Glycine, serine and threonine metabolism

GO:0003824|catalytic activity|IEA; GO:0003870|5-aminolevulinate synthase activity|IEA; GO:0006783|heme biosynthesis|IEA; GO:0008890|glycine C-acetyltransferase activity|IEA; GO:0009058|biosynthesis|IEA; GO:0016874|ligase activity|IEA

ACL00000427

Similar to glycine C-acetyltransferase related cluster

400

1e-38

52% (79/151)

GO:0003824|catalytic activity|IEA; GO:0003870|5-aminolevulinate synthase activity|IEA; GO:0006783|heme biosynthesis|IEA; GO:0008890|glycine C-acetyltransferase activity|IEA; GO:0009058|biosynthesis|IEA

ACL00000428

Ornithine aminotransferase related cluster

447

4e-43

60% (91/150)

Amino acid transport and metabolism

GO:0008483|transaminase activity|IEA; GO:0016740|transferase activity|IEA; GO:0030170|pyridoxal phosphate binding|IEA

ACL00000429

unclassified

ACL00000430

DUF355 domain containing protein

134

1e-09

54% (20/37)

ACL00000431

Unknown EST

143

3e-30

72% (27/37)

ACL00000432

Unknown EST

329

3e-35

84% (69/82)

ACL00000434

zgc:56227

Protein phosphatase 6 catalytic subunit related cluster

1356

1e-148

82% (247/299)

Signal transduction mechanisms

GO:0016787|hydrolase activity|IEA

ACL00000435

RRM domain containing protein

92

8e-06

32% (14/43)

ACL00000436

multi-domain protein

113

3e-06

21% (39/184)

ACL00000437

Putative heat shock protein related cluster

412

1e-39

54% (75/138)

GO:0006457|protein folding|IEA; GO:0006986|response to unfolded protein|IEA; GO:0051082|unfolded protein binding|IEA

ACL00000439

unclassified

ACL00000440

MYA6.7; metallo-beta-lactamase family protein

212

8e-17

56% (40/71)

General function prediction only

ACL00000441

unclassified

ACL00000442

Sec23b

Protein transport protein Sec23B related cluster

518

5e-52

64% (99/154)

GO:0005515|protein binding|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0005794|Golgi apparatus|IEA; GO:0006810|transport|IEA; GO:0006886|intracellular protein transport|IEA; GO:0006888|ER to Golgi transport|IEA; GO:0015031|protein transport|IEA; GO:0016020|membrane|TAS; GO:0016192|vesicle-mediated transport|TAS; GO:0030127|COPII vesicle coat|IEA

ACL00000443

(AL513464) probable SEC23 related cluster

637

2e-65

57% (132/228)

Intracellular trafficking, secretion, and vesicular transport

GO:0005515|protein binding|IEA; GO:0006886|intracellular protein transport|IEA; GO:0006888|ER to Golgi transport|IEA; GO:0030127|COPII vesicle coat|IEA

ACL00000444

VATC

Vacuolar ATP synthase subunit C related cluster

695

6e-72

39% (148/377)

3.6.3.14

Energy production and conversion

ATP synthesis Cholera - Infection Oxidative phosphorylation

GO:0005524|ATP binding|IEA; GO:0006754|ATP biosynthesis|IEA; GO:0015078|hydrogen ion transporter activity|IEA; GO:0015986|ATP synthesis coupled proton transport|IEA; GO:0015992|proton transport|IEA; GO:0016469|proton-transporting two-sector ATPase complex|IEA; GO:0016787|hydrolase activity|IEA; GO:0016820|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|IEA

ACL00000445

unclassified

ACL00000447

Rtn1

Reticulon 1 related cluster

173

8e-12

25% (55/219)

GO:0005554|molecular_function unknown|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0016021|integral to membrane|IEA

ACL00000448

unclassified

ACL00000449

unclassified

ACL00000450

unclassified

ACL00000451

DUF1421 domain containing protein

119

3e-07

27% (28/102)

ACL00000452

Unassigned protein

ACL00000453

unclassified

ACL00000454

UCRI

Ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial precursor related cluster

559

2e-56

55% (107/193)

1.10.2.2

GO:0005739|mitochondrion|IEA; GO:0005746|mitochondrial electron transport chain|IEA; GO:0006118|electron transport|IEA; GO:0008121|ubiquinol-cytochrome-c reductase activity|IEA; GO:0015008|ubiquinol-cytochrome-c reductase complex (sensu Eukaryota)|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0019866|inner membrane|IEA; GO:0045285|ubiquinol-cytochrome-c reductase complex|IEA

ACL00000455

Flavoprotein subunit of succinate dehydrogenase complex related cluster

487

9e-49

71% (86/120)

Energy production and conversion

GO:0006118|electron transport|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016627|oxidoreductase activity, acting on the CH-CH group of donors|IEA

ACL00000456

SdhA related cluster

718

5e-75

67% (138/205)

GO:0000104|succinate dehydrogenase activity|IEA; GO:0006118|electron transport|IEA; GO:0015036|disulfide oxidoreductase activity|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016627|oxidoreductase activity, acting on the CH-CH group of donors|IEA

ACL00000457

FAF protein related cluster

159

3e-10

25% (53/209)

ACL00000458

Appbp1

Amyloid protein-binding protein 1 related cluster

498

2e-49

40% (109/271)

Alzheimer's disease

GO:0003824|catalytic activity|IEA; GO:0005737|cytoplasm|TAS; GO:0006512|ubiquitin cycle|IEA; GO:0006915|apoptosis|IEA; GO:0007049|cell cycle|IEA; GO:0007165|signal transduction|TAS; GO:0016874|ligase activity|IEA

ACL00000459

unclassified

ACL00000460

ECE1

Endothelin-converting enzyme 1 related cluster

504

3e-50

48% (99/205)

3.4.24.71

GO:0004222|metalloendopeptidase activity|TAS; GO:0004245|neprilysin activity|IEA; GO:0005624|membrane fraction|TAS; GO:0006508|proteolysis and peptidolysis|IEA; GO:0007267|cell-cell signaling|NR; GO:0008237|metallopeptidase activity|IEA; GO:0008270|zinc ion binding|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016021|integral to membrane|TAS; GO:0016512|endothelin-converting enzyme 1 activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00000461

multi-domain protein

108

1e-05

24% (43/174)

ACL00000462

unclassified

ACL00000464

PP2Cc domain containing protein

122

1e-08

31% (21/66)

ACL00000465

PDP1

[Pyruvate dehydrogenase [Lipoamide]]-phosphatase 1, mitochondrial precursor related cluster

174

5e-12

30% (43/142)

3.1.3.43

Signal transduction mechanisms

GO:0000287|magnesium ion binding|IEA; GO:0003824|catalytic activity|IEA; GO:0004721|phosphoprotein phosphatase activity|IEA; GO:0004722|protein serine/threonine phosphatase activity|IEA; GO:0004741|[pyruvate dehydrogenase (lipoamide)] phosphatase activity|IEA; GO:0005509|calcium ion binding|IEA; GO:0005739|mitochondrion|IEA; GO:0006470|protein amino acid dephosphorylation|IEA; GO:0008287|protein serine/threonine phosphatase complex|IEA; GO:0016787|hydrolase activity|IEA

ACL00000466

unclassified

ACL00000469

unclassified

ACL00000470

cupin family protein

159

2e-10

34% (40/116)

ACL00000471

multi-domain protein

129

3e-08

25% (33/128)

ACL00000472

Nucleotide exchange factor RasGEF A related cluster

154

4e-10

28% (35/121)

GO:0005085|guanyl-nucleotide exchange factor activity|IEA; GO:0007242|intracellular signaling cascade|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00000473

Putative mitochondrial inner membrane protein related cluster

141

3e-08

30% (32/105)

GO:0005743|mitochondrial inner membrane|IEA; GO:0008565|protein transporter activity|IEA; GO:0015031|protein transport|IEA

ACL00000474

CBS domain containing protein

122

3e-07

36% (18/49)

ACL00000475

MIK19.20; GATA zinc finger protein

157

4e-10

52% (32/61)

ACL00000476

RAD23, isoform I related cluster

217

4e-17

35% (46/128)

GO:0005634|nucleus|IEA; GO:0006289|nucleotide-excision repair|IEA

ACL00000477

unclassified

ACL00000478

Countin related cluster

467

6e-46

46% (92/199)

ACL00000479

Similar to katanin p80 (WD40-containing) subunit B 1 related cluster

214

2e-16

30% (51/169)

General function prediction only

ACL00000483

DM6 domain containing protein

85

1e-04

27% (27/100)

ACL00000484

AFR390Cp

ORF YOR145C related cluster

669

2e-69

66% (132/199)

GO:0003676|nucleic acid binding|IEA; GO:0005634|nucleus|IDA; GO:0005730|nucleolus|IDA; GO:0006364|rRNA processing|IMP; GO:0006365|35S primary transcript processing|IMP; GO:0006461|protein complex assembly|IMP; GO:0051082|unfolded protein binding|IDA

ACL00000485

Unassigned protein

ACL00000486

multi-domain protein

125

1e-07

20% (33/165)

ACL00000488

Tubulin alpha-1B chain related cluster

1778

0.0

74% (325/434)

Cytoskeleton

GO:0003924|GTPase activity|IEA; GO:0005198|structural molecule activity|IEA; GO:0005525|GTP binding|IEA; GO:0005634|nucleus|IEA; GO:0005874|microtubule|IEA; GO:0007018|microtubule-based movement|IEA; GO:0045298|tubulin|IEA; GO:0046785|microtubule polymerization|IEA

ACL00000489

GTP-binding protein related cluster

559

1e-56

62% (109/174)

Translation, ribosomal structure and biogenesis

GO:0005525|GTP binding|IEA; GO:0005554|molecular_function unknown|IEA

ACL00000490

NBMPR-insensitive nucleoside transporter ei

133

2e-07

24% (38/157)

ACL00000491

DNCLI2

Dynein light intermediate chain 2, cytosolic related cluster

455

2e-44

34% (99/290)

GO:0003774|motor activity|IEA; GO:0005524|ATP binding|IEA; GO:0005868|cytoplasmic dynein complex|TAS; GO:0030286|dynein complex|IEA

ACL00000492

multi-domain protein

121

4e-07

22% (39/177)

ACL00000493

unclassified

ACL00000496

DUF614 domain containing protein

219

2e-18

25% (29/115)

ACL00000497

Kynurenine 3-monooxygenase related cluster

222

5e-18

43% (54/125)

1.14.13.9

Tryptophan metabolism

GO:0004497|monooxygenase activity|IEA; GO:0004502|kynurenine 3-monooxygenase activity|IEA; GO:0006725|aromatic compound metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000498

Kynurenine 3-monooxygenase related cluster

477

5e-47

45% (94/207)

1.14.13.9

Tryptophan metabolism

GO:0004497|monooxygenase activity|IEA; GO:0006118|electron transport|IEA; GO:0006725|aromatic compound metabolism|IEA; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000499

multi-domain protein

132

2e-08

25% (25/97)

ACL00000500

multi-domain protein

109

9e-06

21% (40/184)

ACL00000501

unclassified

ACL00000502

26S protease regulatory subunit 4 related cluster

491

7e-49

66% (92/139)

Posttranslational modification, protein turnover, chaperones

Proteasome

GO:0000502|proteasome complex (sensu Eukaryota)|TAS; GO:0016887|ATPase activity|TAS

ACL00000503

26S protease regulatory subunit 6A related cluster

1186

1e-129

61% (235/380)

Posttranslational modification, protein turnover, chaperones

GO:0000166|nucleotide binding|IEA; GO:0000502|proteasome complex (sensu Eukaryota)|TAS; GO:0003713|transcription coactivator activity|TAS; GO:0003714|transcription corepressor activity|TAS; GO:0005524|ATP binding|IEA; GO:0005634|nucleus|IEA; GO:0005634|nucleus|TAS; GO:0005737|cytoplasm|IEA; GO:0005829|cytosol|IEA; GO:0016787|hydrolase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA; GO:0030163|protein catabolism|IEA

ACL00000504

unclassified

ACL00000505

Tymo_45kd_70kd domain containing protein

114

3e-06

18% (43/236)

ACL00000506

Carboxypeptidase type III related cluster

158

1e-10

37% (41/108)

3.4.16.-

GO:0003824|catalytic activity|IEA; GO:0004180|carboxypeptidase activity|IEA; GO:0004185|serine carboxypeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA

ACL00000507

Peripheral-type benzodiazepine receptor related cluster

378

9e-36

51% (81/156)

Signal transduction mechanisms

GO:0004872|receptor activity|IEA; GO:0016021|integral to membrane|IEA

ACL00000508

unclassified

ACL00000509

Unknown EST

128

7e-08

31% (29/92)

ACL00000510

unclassified

ACL00000511

unclassified

ACL00000513

hemC

Porphobilinogen deaminase related cluster

792

1e-83

82% (156/190)

2.5.1.61

Coenzyme transport and metabolism

Porphyrin and chlorophyll metabolism

GO:0004418|hydroxymethylbilane synthase activity|IEA; GO:0006779|porphyrin biosynthesis|IEA; GO:0016740|transferase activity|IEA

ACL00000514

Hydroxyacylglutathione hydrolase related cluster

234

6e-19

30% (52/168)

GO:0004416|hydroxyacylglutathione hydrolase activity|IEA

ACL00000515

unclassified

ACL00000516

CBS domain protein related cluster

223

2e-17

26% (79/301)

General function prediction only

ACL00000517

unclassified

ACL00000518

Cd36

Cd36; CD36 antigen

128

1e-06

28% (33/116)

ACL00000519

multi-domain protein

125

1e-07

20% (36/176)

ACL00000521

unclassified

ACL00000522

Severin kinase related cluster

864

6e-92

83% (162/195)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0004713|protein-tyrosine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA

ACL00000523

multi-domain protein

126

1e-07

25% (42/167)

ACL00000524

unclassified

ACL00000525

GTP-binding protein SAS1 related cluster

110

1e-80

75% (22/29)

General function prediction only

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00000526

NDK

Nucleoside diphosphate kinase related cluster

153

6e-10

41% (33/80)

2.7.4.6

Nucleotide transport and metabolism

Purine metabolism Pyrimidine metabolism

GO:0000166|nucleotide binding|IEA; GO:0000287|magnesium ion binding|IEA; GO:0004550|nucleoside-diphosphate kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006183|GTP biosynthesis|IEA; GO:0006228|UTP biosynthesis|IEA; GO:0006241|CTP biosynthesis|IEA; GO:0009117|nucleotide metabolism|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00000531

unclassified

ACL00000532

fixL

Sensor protein fixL related cluster

239

2e-19

35% (50/141)

2.7.3.-

GO:0000155|two-component sensor molecule activity|IEA; GO:0000160|two-component signal transduction system (phosphorelay)|IEA; GO:0004871|signal transducer activity|IEA; GO:0005524|ATP binding|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0007165|signal transduction|IEA; GO:0007600|sensory perception|IEA; GO:0009399|nitrogen fixation|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016301|kinase activity|IEA; GO:0016310|phosphorylation|IEA; GO:0016740|transferase activity|IEA; GO:0016772|transferase activity, transferring phosphorus-containing groups|IEA; GO:0019866|inner membrane|IEA

ACL00000533

unclassified

ACL00000535

unclassified

ACL00000537

unclassified

ACL00000539

unclassified

ACL00000540

GYAR

Glyoxylate reductase related cluster

500

9e-50

50% (105/207)

1.1.1.26

GO:0006564|L-serine biosynthesis|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016616|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|IEA; GO:0047964|glyoxylate reductase activity|IEA

ACL00000541

PURA

Adenylosuccinate synthetase related cluster

339

1e-141

65% (56/85)

6.3.4.4

Nucleotide transport and metabolism

Alanine and aspartate metabolism Purine metabolism

GO:0000287|magnesium ion binding|IEA; GO:0004019|adenylosuccinate synthase activity|IEA; GO:0005525|GTP binding|IEA; GO:0006164|purine nucleotide biosynthesis|IEA; GO:0016874|ligase activity|IEA

ACL00000544

Unassigned protein

ACL00000545

AAR057Wp

Periodic tryptophan protein 2 related cluster

434

3e-42

44% (89/200)

GO:0000910|cytokinesis|IMP; GO:0005634|nucleus|IEA; GO:0005732|small nucleolar ribonucleoprotein complex|IPI; GO:0005737|cytoplasm|IDA; GO:0006364|rRNA processing|IEA; GO:0007046|ribosome biogenesis|IEA; GO:0030468|establishment of cell polarity (sensu Fungi)|IMP; GO:0030490|processing of 20S pre-rRNA|IMP; GO:0030515|snoRNA binding|IPI

ACL00000546

DM6 domain containing protein

86

1e-04

27% (27/100)

ACL00000547

unclassified

ACL00000548

Unassigned protein

ACL00000549

KPRS

Ribose-phosphate pyrophosphokinase related cluster

577

2e-58

52% (124/237)

2.7.6.1

Pentose phosphate pathway Purine metabolism

GO:0000287|magnesium ion binding|IEA; GO:0004749|ribose-phosphate diphosphokinase activity|IEA; GO:0009116|nucleoside metabolism|IEA; GO:0009156|ribonucleoside monophosphate biosynthesis|IEA; GO:0009165|nucleotide biosynthesis|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00000551

Calmodulin related cluster

194

3e-14

32% (46/141)

GO:0005509|calcium ion binding|IEA

ACL00000552

REN protein related cluster

264

7e-23

100% (52/52)

ACL00000554

Putative mRNA export protein related cluster

592

2e-60

58% (105/178)

ACL00000555

Deoxyribonuclease, TatD family related cluster

172

5e-12

30% (45/146)

ACL00000556

multi-domain protein

109

9e-07

47% (18/38)

ACL00000557

unclassified

ACL00000558

unclassified

ACL00000559

unclassified

ACL00000561

CGI-141

UPF0198 protein CGI-141 related cluster

314

3e-28

43% (59/137)

GO:0004871|signal transducer activity|IMP; GO:0016021|integral to membrane|IEA; GO:0016192|vesicle-mediated transport|IEA; GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB cascade|IMP

ACL00000563

unclassified

ACL00000564

unclassified

ACL00000565

JAB related cluster

1131

1e-122

73% (214/291)

General function prediction only

ACL00000566

DUF540 domain containing protein

117

7e-07

36% (22/60)

ACL00000567

unclassified

ACL00000568

multi-domain protein

114

2e-06

26% (23/88)

ACL00000569

Aquaporin related cluster

251

8e-21

34% (73/213)

GO:0005215|transporter activity|IEA; GO:0006810|transport|IEA; GO:0015288|porin activity|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0019867|outer membrane|IEA

ACL00000570

unclassified

ACL00000571

Putative snRNP protein related cluster

285

1e-24

61% (57/93)

Transcription

GO:0005634|nucleus|IEA; GO:0005654|nucleoplasm|IDA; GO:0005732|small nucleolar ribonucleoprotein complex|IEA; GO:0006397|mRNA processing|IEA; GO:0008248|pre-mRNA splicing factor activity|IEA; GO:0015030|Cajal body|IDA; GO:0030529|ribonucleoprotein complex|IEA

ACL00000572

FBOX domain containing protein

94

1e-05

30% (12/39)

ACL00000573

Ribosomal protein L10a related cluster

228

2e-18

34% (65/190)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000574

unclassified

ACL00000575

unclassified

ACL00000576

unclassified

ACL00000577

eef2l

Elongation factor 2 related cluster

749

1e-165

72% (139/192)

Translation, ribosomal structure and biogenesis

GO:0003746|translation elongation factor activity|IEA; GO:0003746|translation elongation factor activity|NR; GO:0005525|GTP binding|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006414|translational elongation|IEA

ACL00000579

POZ 56 protein homolog related cluster

130

2e-07

31% (33/104)

GO:0005515|protein binding|IEA

ACL00000580

Alkylated DNA repair protein related cluster

188

4e-14

37% (49/131)

Replication, recombination and repair

ACL00000581

Biotin synthetase, putative related cluster

220

9e-18

45% (51/112)

2.8.1.6

Biotin metabolism

GO:0003824|catalytic activity|IEA; GO:0005506|iron ion binding|IEA

ACL00000582

[O] COG5272 Ubiquitin

169

3e-12

48% (34/70)

Posttranslational modification, protein turnover, chaperones

ACL00000583

P-glycoprotein related cluster

329

4e-30

57% (64/111)

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0006810|transport|IEA; GO:0016021|integral to membrane|IEA; GO:0016887|ATPase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA; GO:0042626|ATPase activity, coupled to transmembrane movement of substances|IEA

ACL00000584

unclassified

ACL00000585

unclassified

ACL00000586

dld, RSc2664

Putative D-lactate dehydrogenase (Cytochrome) oxidoreductase protein related cluster

274

7e-24

48% (53/109)

1.1.2.4

Energy production and conversion

Pyruvate metabolism

GO:0004458|D-lactate dehydrogenase (cytochrome) activity|IEA; GO:0006118|electron transport|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000587

unclassified

ACL00000588

multi-domain protein

118

1e-06

23% (43/181)

ACL00000589

Maf1

Maf1; MAF1 homolog (yeast)

248

3e-21

45% (48/106)

ACL00000591

Putative membrane protein related cluster

290

2e-25

37% (63/170)

Function unknown

GO:0005554|molecular_function unknown|IEA; GO:0016020|membrane|IEA

ACL00000592

Ribosomal protein S4 related cluster

954

1e-102

67% (171/252)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003723|RNA binding|IEA; GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000593

SURE

Acid phosphatase surE related cluster

349

5e-32

31% (85/274)

3.1.3.2

General function prediction only

Riboflavin metabolism gamma-Hexachlorocyclohexane degradation

GO:0000287|magnesium ion binding|IEA; GO:0003993|acid phosphatase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00000594

F19G10.24; oxidoreductase, 2OG-Fe(II) oxygenase family protein

462

2e-45

54% (83/151)

ACL00000595

Similar to Homo sapiens (Human). high-risk human papilloma viruses E6 oncoproteins targeted protein E6TP1 alpha related cluster

179

5e-13

37% (38/102)

ACL00000598

ABCF2

Putative ABC transporter related cluster

145

3e-08

25% (54/212)

General function prediction only

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0016887|ATPase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

ACL00000600

unclassified

ACL00000601

unclassified

ACL00000602

unclassified

ACL00000604

unclassified

ACL00000605

Unassigned protein

ACL00000606

NADP-reducing hydrogenase, subunit D, putative related cluster

517

1e-51

45% (109/237)

1.6.5.3

General function prediction only

Oxidative phosphorylation Ubiquinone biosynthesis

GO:0005489|electron transporter activity|IEA; GO:0005506|iron ion binding|IEA; GO:0006118|electron transport|IEA; GO:0008901|ferredoxin hydrogenase activity|IEA

ACL00000607

unclassified

ACL00000608

multi-domain protein

115

2e-06

51% (25/49)

ACL00000610

Sc5d

Sc5d; sterol-C5-desaturase (fungal ERG3, delta-5-desaturase)-like

731

3e-76

51% (135/261)

Lipid transport and metabolism

ACL00000611

Sm-like protein related cluster

232

4e-19

54% (49/90)

Transcription

GO:0005634|nucleus|IEA; GO:0005732|small nucleolar ribonucleoprotein complex|IEA; GO:0006397|mRNA processing|IEA; GO:0008248|pre-mRNA splicing factor activity|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00000612

F18B13.17; CBS domain-containing protein

141

8e-08

21% (75/351)

General function prediction only

ACL00000613

ZRF1

Zuotin related factor-1 related cluster

142

2e-08

50% (27/54)

GO:0003677|DNA binding|IEA; GO:0005634|nucleus|IEA; GO:0005634|nucleus|NAS; GO:0006457|protein folding|IEA; GO:0006457|protein folding|NAS; GO:0051082|unfolded protein binding|IEA; GO:0051082|unfolded protein binding|NAS

ACL00000614

LYS1

Saccharopine dehydrogenase [NAD+, L-lysine forming] related cluster

377

2e-35

41% (93/225)

1.5.1.7

Lysine biosynthesis Lysine degradation

GO:0004754|saccharopine dehydrogenase (NAD+, L-lysine-forming) activity|IEA; GO:0006118|electron transport|IEA; GO:0009085|lysine biosynthesis|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000615

unclassified

ACL00000616

unclassified

ACL00000617

Exosome complex exonuclease RRP40 related cluster

443

3e-43

45% (90/200)

GO:0000178|exosome (RNase complex)|IEA; GO:0003723|RNA binding|IEA; GO:0004518|nuclease activity|IEA; GO:0004527|exonuclease activity|IEA; GO:0005634|nucleus|IEA; GO:0006364|rRNA processing|IEA; GO:0016787|hydrolase activity|IEA

ACL00000618

cysM

Cysteine synthase related cluster

299

2e-26

42% (62/146)

2.5.1.47

Amino acid transport and metabolism

Cysteine metabolism Selenoamino acid metabolism Sulfur metabolism

GO:0003824|catalytic activity|IEA; GO:0006535|cysteine biosynthesis from serine|IEA; GO:0008152|metabolism|IEA; GO:0008652|amino acid biosynthesis|IEA; GO:0016740|transferase activity|IEA; GO:0019344|cysteine biosynthesis|IEA

ACL00000620

Putative RING zinc finger protein related cluster

209

5e-16

29% (48/164)

GO:0000151|ubiquitin ligase complex|IEA; GO:0004842|ubiquitin-protein ligase activity|IEA; GO:0008270|zinc ion binding|IEA; GO:0016567|protein ubiquitination|IEA

ACL00000621

unclassified

ACL00000622

unclassified

ACL00000623

Trehalose-6-phosphate synthase homolog related cluster

215

8e-17

29% (51/175)

Carbohydrate transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0003825|alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity|IEA; GO:0004805|trehalose-phosphatase activity|IEA; GO:0005992|trehalose biosynthesis|IEA; GO:0008152|metabolism|IEA

ACL00000624

Sec61_beta domain containing protein

146

4e-10

45% (20/44)

ACL00000625

UPF0057 domain containing protein

186

6e-15

60% (30/50)

ACL00000626

UCR7

Probable ubiquinol-cytochrome C reductase complex 14 kDa protein related cluster

188

7e-14

43% (39/89)

1.10.2.2

Oxidative phosphorylation

GO:0005739|mitochondrion|IEA; GO:0005746|mitochondrial electron transport chain|IEA; GO:0006118|electron transport|IEA; GO:0006122|mitochondrial electron transport, ubiquinol to cytochrome c|IEA; GO:0008121|ubiquinol-cytochrome-c reductase activity|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0019866|inner membrane|IEA

ACL00000627

purH

IMP cyclohydrolase related cluster

576

2e-58

49% (130/263)

2.1.2.3 3.5.4.10

Nucleotide transport and metabolism

One carbon pool by folate Purine metabolism

GO:0003937|IMP cyclohydrolase activity|IEA; GO:0004643|phosphoribosylaminoimidazolecarboxamide formyltransferase activity|IEA; GO:0006164|purine nucleotide biosynthesis|IEA; GO:0016787|hydrolase activity|IEA

ACL00000629

Nodulin-like protein related cluster

225

8e-18

28% (59/207)

ACL00000630

Putative hydrolase related cluster

453

3e-44

43% (85/194)

General function prediction only

ACL00000632

wcaA

Possible glycosyl transferase related cluster

180

2e-12

37% (41/109)

Cell wall/membrane/envelope biogenesis

GO:0016740|transferase activity|IEA

ACL00000633

Ribosomal_L32p domain containing protein

133

1e-08

38% (20/52)

ACL00000634

Pyrrolidone carboxyl peptidase-like protein related cluster

298

2e-26

37% (76/202)

Posttranslational modification, protein turnover, chaperones

GO:0004219|pyroglutamyl-peptidase I activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA

ACL00000635

Initiation factor 3g related cluster

394

3e-37

38% (110/286)

GO:0003676|nucleic acid binding|IEA; GO:0003723|RNA binding|IEA; GO:0003743|translation initiation factor activity|IEA

ACL00000636

unclassified

ACL00000637

unclassified

ACL00000638

Transposase related cluster

260

1e-21

31% (75/239)

Replication, recombination and repair

ACL00000640

unclassified

ACL00000641

Diphosphonucleotide phosphatase-like protein related cluster

464

1e-45

40% (94/231)

GO:0016787|hydrolase activity|IEA

ACL00000642

spi1

GTP-binding nuclear protein spi1 related cluster

737

3e-77

77% (139/180)

General function prediction only

GO:0005525|GTP binding|IEA; GO:0005634|nucleus|IEA; GO:0006886|intracellular protein transport|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00000643

unclassified

ACL00000644

unclassified

ACL00000645

ACBP/ECHM related cluster

194

9e-15

53% (35/65)

GO:0000062|acyl-CoA binding|IEA; GO:0003824|catalytic activity|IEA; GO:0008152|metabolism|IEA

ACL00000646

multi-domain protein

115

3e-06

20% (56/272)

ACL00000647

F27H5.50; phagocytosis and cell motility protein ELMO1-related

268

8e-23

29% (69/237)

ACL00000648

Phospholipid scramblase 1 related cluster

119

1e-05

28% (42/149)

GO:0005509|calcium ion binding|IEA; GO:0016021|integral to membrane|IEA

ACL00000649

zgc:55762

Similar to serologically defined breast cancer antigen 84 related cluster

1005

1e-108

60% (189/312)

ACL00000650

Putative plant adhesion molecule related cluster

295

2e-26

41% (55/131)

ACL00000651

CG8472

Calmodulin related cluster

411

1e-39

53% (78/147)

Phosphatidylinositol signaling system

GO:0005509|calcium ion binding|IEA

ACL00000654

multi-domain protein

115

2e-06

21% (28/130)

ACL00000655

Unassigned protein

209

3e-16

41% (41/100)

ACL00000656

unclassified

ACL00000657

ARPC2

ARP2/3 complex 34 kDa subunit related cluster

595

1e-60

45% (124/274)

Regulation of actin cytoskeleton

GO:0005200|structural constituent of cytoskeleton|TAS; GO:0005856|cytoskeleton|IEA; GO:0005885|Arp2/3 protein complex|TAS; GO:0006928|cell motility|TAS; GO:0015629|actin cytoskeleton|TAS; GO:0030833|regulation of actin filament polymerization|IEA

ACL00000658

unclassified

ACL00000659

unclassified

ACL00000661

MutT/nudix family protein related cluster

396

1e-37

43% (82/188)

GO:0016787|hydrolase activity|IEA

ACL00000662

Herpes_gp2 domain containing protein

111

6e-06

22% (28/123)

ACL00000663

hcP-1

hcP-1; prismane protein

918

5e-98

60% (173/287)

Energy production and conversion

ACL00000664

multi-domain protein

109

9e-06

20% (35/172)

ACL00000665

Ribosomal protein L18 related cluster

152

1e-50

49% (30/61)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000666

Possible ribosomal L21-like protein related cluster

164

9e-11

64% (34/53)

Translation, ribosomal structure and biogenesis

GO:0003723|RNA binding|IEA; GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000667

Serpin 4 related cluster

313

5e-28

34% (75/219)

GO:0004866|endopeptidase inhibitor activity|IEA; GO:0004867|serine-type endopeptidase inhibitor activity|IEA

ACL00000668

TPIS

Triosephosphate isomerase, cytosolic related cluster

732

2e-76

61% (147/239)

5.3.1.1

Carbohydrate transport and metabolism

Carbon fixation Fructose and mannose metabolism Glycerolipid metabolism Glycolysis / Gluconeogenesis Inositol metabolism

GO:0004807|triose-phosphate isomerase activity|IEA; GO:0006094|gluconeogenesis|IEA; GO:0006096|glycolysis|IEA; GO:0006098|pentose-phosphate shunt|IEA; GO:0006633|fatty acid biosynthesis|IEA; GO:0008152|metabolism|IEA; GO:0016853|isomerase activity|IEA

ACL00000669

Similar to Dictyostelium discoideum (Slime mold). myosin I heavy chain kinase related cluster

468

4e-46

72% (88/122)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA

ACL00000670

CG9277

Tubulin beta-1 chain related cluster

1137

1e-123

80% (213/266)

Cytoskeleton

GO:0003924|GTPase activity|IEA; GO:0005198|structural molecule activity|IEA; GO:0005525|GTP binding|IEA; GO:0005634|nucleus|IEA; GO:0005874|microtubule|IEA; GO:0007018|microtubule-based movement|IEA; GO:0045298|tubulin|IEA; GO:0046785|microtubule polymerization|IEA

ACL00000671

FAS1 domain containing protein

86

1e-04

30% (25/83)

ACL00000672

Herpes_gp2 domain containing protein

111

5e-06

21% (46/210)

ACL00000673

Heat shock protein Ddj1 related cluster

371

9e-35

43% (83/190)

GO:0006457|protein folding|IEA; GO:0006986|response to unfolded protein|IEA; GO:0051082|unfolded protein binding|IEA

ACL00000674

SLC25A11

Mitochondrial 2-oxoglutarate/malate carrier protein related cluster

743

8e-78

56% (145/255)

GO:0005215|transporter activity|IEA; GO:0005488|binding|IEA; GO:0005739|mitochondrion|IEA; GO:0005743|mitochondrial inner membrane|IEA; GO:0005743|mitochondrial inner membrane|TAS; GO:0005887|integral to plasma membrane|TAS; GO:0006810|transport|IEA; GO:0006810|transport|TAS; GO:0015367|oxoglutarate:malate antiporter activity|TAS; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0019866|inner membrane|IEA

ACL00000675

Unassigned protein

ACL00000676

CG13852

CG13852; CG13852 gene product

704

2e-73

62% (127/203)

ACL00000677

TNKS2

Tankyrase 2 related cluster

185

2e-13

42% (47/110)

2.4.2.30

GO:0000781|chromosome, telomeric region|IEA; GO:0003950|NAD+ ADP-ribosyltransferase activity|IEA; GO:0005634|nucleus|IEA; GO:0005794|Golgi apparatus|IEA; GO:0007004|telomerase-dependent telomere maintenance|IEA; GO:0016740|transferase activity|IEA; GO:0016757|transferase activity, transferring glycosyl groups|IEA

ACL00000678

HBXIP

Hepatitis B virus X interacting protein related cluster

120

4e-06

28% (25/89)

GO:0009615|response to virus|TAS; GO:0019079|viral genome replication|TAS

ACL00000679

Stard10

Stard10; START domain containing 10

142

3e-08

26% (44/165)

ACL00000680

Ppp2ca

Protein phosphatase 2A catalytic subunit related cluster

1447

1e-159

85% (258/301)

3.1.3.16

Signal transduction mechanisms

TGF-beta signaling pathway Wnt signaling pathway

GO:0016787|hydrolase activity|IEA

ACL00000681

Unassigned protein

ACL00000682

FBOX domain containing protein

90

5e-05

35% (12/34)

ACL00000683

Oligosaccharyl transferase STT3 subunit homolog related cluster

975

1e-104

68% (182/264)

GO:0004576|oligosaccharyl transferase activity|IEA; GO:0005624|membrane fraction|TAS; GO:0005887|integral to plasma membrane|TAS; GO:0006486|protein amino acid glycosylation|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA

ACL00000684

Protein kinase related cluster

128

3e-06

24% (48/196)

GO:0016301|kinase activity|IEA

ACL00000685

unclassified

ACL00000686

Commd4

Commd4; COMM domain containing 4

409

3e-39

44% (89/201)

ACL00000688

multi-domain protein

140

3e-09

22% (53/237)

ACL00000689

multi-domain protein

121

4e-07

24% (36/148)

ACL00000690

multi-domain protein

117

1e-06

20% (36/172)

ACL00000692

HSC20

Co-chaperone protein HscB, mitochondrial precursor related cluster

324

2e-29

34% (67/194)

Posttranslational modification, protein turnover, chaperones

GO:0005739|mitochondrion|IEA; GO:0006457|protein folding|IEA; GO:0051082|unfolded protein binding|IEA; GO:0051087|chaperone binding|IEA

ACL00000693

unclassified

ACL00000694

putative permease

157

4e-10

37% (40/107)

ACL00000695

Inosine-uridine preferring nucleoside hydrolase related cluster

187

4e-13

27% (56/207)

Nucleotide transport and metabolism

Nicotinate and nicotinamide metabolism Purine metabolism

GO:0005975|carbohydrate metabolism|IEA; GO:0008477|purine nucleosidase activity|IEA; GO:0016787|hydrolase activity|IEA; GO:0016798|hydrolase activity, acting on glycosyl bonds|IEA

ACL00000696

FBL

Fibrillarin related cluster

994

1e-106

77% (184/236)

Translation, ribosomal structure and biogenesis

GO:0003723|RNA binding|IEA; GO:0005634|nucleus|IEA; GO:0006364|rRNA processing|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00000697

PPT1

Palmitoyl-protein thioesterase 1 precursor related cluster

472

9e-47

51% (91/176)

3.1.2.22

GO:0003824|catalytic activity|IEA; GO:0005764|lysosome|IEA; GO:0006464|protein modification|IEA; GO:0008474|palmitoyl-(protein) hydrolase activity|IEA; GO:0016787|hydrolase activity|IEA; GO:0048167|regulation of synaptic plasticity|TAS

ACL00000698

multi-domain protein

127

1e-07

21% (47/218)

ACL00000699

t_SNARE domain containing protein

109

4e-07

25% (17/68)

ACL00000703

Putative FtsH protease related cluster

503

4e-50

56% (103/182)

Posttranslational modification, protein turnover, chaperones

GO:0000166|nucleotide binding|IEA; GO:0000910|cytokinesis|IEA; GO:0004176|ATP-dependent peptidase activity|IEA; GO:0004222|metalloendopeptidase activity|IEA; GO:0004252|serine-type endopeptidase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0016020|membrane|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA; GO:0030163|protein catabolism|IEA

ACL00000704

aroQ

3-dehydroquinate dehydratase, type II related cluster

154

4e-10

41% (37/89)

4.2.1.10

Amino acid transport and metabolism

Phenylalanine, tyrosine and tryptophan biosynthesis

GO:0003855|3-dehydroquinate dehydratase activity|IEA; GO:0009073|aromatic amino acid family biosynthesis|IEA

ACL00000705

MTMR3

Similar to myotubularin related protein 3 related cluster

184

2e-13

30% (39/127)

3.1.3.48

GO:0008270|zinc ion binding|IEA

ACL00000707

AGL250Wp

Nucleolar protein Nop4 related cluster

145

4e-09

48% (36/75)

GO:0003723|RNA binding|IEA

ACL00000708

Copz1

Coatomer zeta-1 subunit related cluster

245

3e-20

34% (62/182)

Posttranslational modification, protein turnover, chaperones

ACL00000709

Similar to Oryza sativa (Rice). 36I5.3 related cluster

169

7e-12

41% (42/101)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA

ACL00000710

unclassified

ACL00000714

unclassified

ACL00000717

YbaK/EbsC protein

289

1e-25

50% (59/117)

ACL00000718

PFC0975c, CPR3

Cyclophilin 1 related cluster

103

2e-47

47% (21/44)

5.2.1.8

Posttranslational modification, protein turnover, chaperones

GO:0003755|peptidyl-prolyl cis-trans isomerase activity|IEA; GO:0006457|protein folding|IEA; GO:0016853|isomerase activity|IEA

ACL00000720

Ras-related protein Rap-1 related cluster

731

2e-76

85% (143/167)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00000724

unclassified

ACL00000725

Phospholipid hydroperoxide glutathione peroxidase B related cluster

451

1e-43

54% (84/155)

Posttranslational modification, protein turnover, chaperones

GO:0004601|peroxidase activity|IEA; GO:0004602|glutathione peroxidase activity|IEA; GO:0006979|response to oxidative stress|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0047066|phospholipid-hydroperoxide glutathione peroxidase activity|IEA

ACL00000726

CYP7

Peptidyl-prolyl cis-trans isomerase 7 related cluster

537

5e-54

68% (98/144)

5.2.1.8

Posttranslational modification, protein turnover, chaperones

GO:0003755|peptidyl-prolyl cis-trans isomerase activity|IEA; GO:0006457|protein folding|IEA; GO:0016853|isomerase activity|IEA

ACL00000727

Nonspecific lipid-transfer protein, mitochondrial precursor related cluster

197

1e-14

50% (41/81)

GO:0005498|sterol carrier activity|IEA; GO:0005498|sterol carrier activity|TAS; GO:0005739|mitochondrion|IEA; GO:0005777|peroxisome|IEA; GO:0005777|peroxisome|TAS; GO:0006694|steroid biosynthesis|TAS; GO:0006810|transport|IEA; GO:0006869|lipid transport|IEA; GO:0008289|lipid binding|IEA

ACL00000728

unclassified

ACL00000729

Arhgap7

Rho-GTPase-activating protein 7 related cluster

142

3e-08

30% (49/159)

GO:0005096|GTPase activator activity|IEA; GO:0005100|Rho GTPase activator activity|NAS; GO:0005515|protein binding|NAS; GO:0005737|cytoplasm|NAS; GO:0007010|cytoskeleton organization and biogenesis|NAS; GO:0030155|regulation of cell adhesion|NAS; GO:0030308|negative regulation of cell growth|IDA

ACL00000732

Putative mitochondrial processing peptidase related cluster

330

2e-30

45% (68/150)

General function prediction only

GO:0004222|metalloendopeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA

ACL00000733

MRC8.21; oxidoreductase, 2OG-Fe(II) oxygenase family protein

358

4e-33

32% (81/253)

ACL00000734

unclassified

ACL00000735

ECHM

Enoyl-CoA hydratase, mitochondrial precursor related cluster

812

1e-85

62% (159/255)

4.2.1.17

Lipid transport and metabolism

Benzoate degradation via CoA ligation Butanoate metabolism Fatty acid biosynthesis (path 2) Fatty acid metabolism Limonene and pinene degradation Lysine degradation Propanoate metabolism Tryptophan metabolism Valine, leucine and isoleucine degradation beta-Alanine metabolism

GO:0003824|catalytic activity|IEA; GO:0004300|enoyl-CoA hydratase activity|IEA; GO:0005739|mitochondrion|IEA; GO:0006631|fatty acid metabolism|IEA; GO:0008152|metabolism|IEA; GO:0016829|lyase activity|IEA

ACL00000736

CBS domain protein related cluster

185

8e-13

23% (70/301)

General function prediction only

ACL00000739

Rehydrin related cluster

753

4e-79

64% (137/212)

ACL00000741

Putative RNA helicase related cluster

698

7e-73

87% (129/147)

GO:0003676|nucleic acid binding|IEA; GO:0004386|helicase activity|IEA; GO:0005524|ATP binding|IEA; GO:0008026|ATP-dependent helicase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00000742

60S ribosomal protein L10 related cluster

797

4e-84

75% (145/193)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000746

DM6 domain containing protein

94

2e-05

36% (24/66)

ACL00000748

unclassified

ACL00000750

Probable ATP-dependent RNA helicase HAS1 related cluster

707

6e-74

69% (127/182)

GO:0003676|nucleic acid binding|IEA; GO:0003723|RNA binding|IEA; GO:0004386|helicase activity|IEA; GO:0005524|ATP binding|IEA; GO:0005634|nucleus|IEA; GO:0005635|nuclear membrane|IDA; GO:0005730|nucleolus|IDA; GO:0006364|rRNA processing|IEA; GO:0006364|rRNA processing|IMP; GO:0007046|ribosome biogenesis|IEA; GO:0008026|ATP-dependent helicase activity|IEA

ACL00000751

MOBKL1A

MOBKL1A; MOB1, Mps One Binder kinase activator-like 1A (yeast)

337

2e-31

75% (60/80)

ACL00000752

Unassigned protein

ACL00000753

p450 domain containing protein

121

4e-07

25% (26/104)

ACL00000754

UMP1 domain containing protein

214

5e-18

33% (38/114)

ACL00000755

CCT chaperonin theta subunit related cluster

62

2e-34

54% (12/22)

Posttranslational modification, protein turnover, chaperones

GO:0005524|ATP binding|IEA; GO:0006457|protein folding|IEA; GO:0051082|unfolded protein binding|IEA

ACL00000756

unclassified

ACL00000757

Eukaryotic peptide chain release factor subunit 1 related cluster

640

5e-66

71% (113/157)

Translation, ribosomal structure and biogenesis

GO:0005737|cytoplasm|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006415|translational termination|IEA; GO:0006415|translational termination|IMP; GO:0016149|translation release factor activity, codon specific|IEA; GO:0035071|salivary gland cell death|IEP; GO:0048102|autophagic cell death|IEP

ACL00000758

unclassified

ACL00000760

Immunophilin FK506 binding protein FKBP12 related cluster

327

6e-30

54% (58/106)

GO:0006457|protein folding|IEA

ACL00000761

SODF

Superoxide dismutase [Fe] related cluster

434

6e-42

44% (86/194)

1.15.1.1

Inorganic ion transport and metabolism

GO:0004784|superoxide dismutase activity|IEA; GO:0006801|superoxide metabolism|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0046872|metal ion binding|IEA

ACL00000762

[P] COG3221 ABC-type phosphate/phosphonate transport system, periplasmic component

172

2e-12

44% (40/89)

Inorganic ion transport and metabolism

ACL00000764

unclassified

ACL00000765

60S ribosomal protein L17 related cluster

464

6e-46

75% (89/118)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0015934|large ribosomal subunit|IEA

ACL00000767

Cytochrome c1 related cluster

759

2e-79

59% (138/233)

Energy production and conversion

Oxidative phosphorylation

GO:0005489|electron transporter activity|IEA; GO:0005739|mitochondrion|IEA; GO:0005746|mitochondrial electron transport chain|IEA; GO:0006118|electron transport|IEA; GO:0008121|ubiquinol-cytochrome-c reductase activity|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000768

Glutaredoxin-related protein related cluster

278

5e-24

48% (48/98)

Posttranslational modification, protein turnover, chaperones

GO:0005489|electron transporter activity|IEA; GO:0006118|electron transport|IEA

ACL00000769

Unknown EST

55

4e-06

52% (13/25)

ACL00000771

unclassified

ACL00000772

Fatty acid synthetase beta-subunit related cluster

203

8e-16

61% (35/57)

GO:0004312|fatty-acid synthase activity|IEA; GO:0005835|fatty-acid synthase complex|IEA; GO:0006633|fatty acid biosynthesis|IEA; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016740|transferase activity|IEA

ACL00000773

Unassigned protein

90

4e-09

42% (21/49)

ACL00000774

unclassified

ACL00000775

bioB

Biotin synthase and related enzymes related cluster

79

6e-27

53% (16/30)

2.8.1.6

Biotin metabolism

GO:0003824|catalytic activity|IEA; GO:0005506|iron ion binding|IEA

ACL00000776

dapE

dapE; succinyl-diaminopimelate desuccinylase

404

5e-39

50% (77/151)

ACL00000777

Peroxidase ppod2 related cluster

161

6e-10

33% (40/118)

GO:0004601|peroxidase activity|IEA

ACL00000778

unclassified

ACL00000779

NIFU-like protein related cluster

157

3e-44

76% (29/38)

Energy production and conversion

ACL00000780

unclassified

ACL00000781

Putative flavonol synthase-like protein related cluster

220

1e-17

46% (50/108)

General function prediction only

GO:0005506|iron ion binding|IEA; GO:0016216|isopenicillin-N synthase activity|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0017000|antibiotic biosynthesis|IEA

ACL00000782

IGF2R

Mannose-6-phosphate/insulin-like growth factor II receptor related cluster

130

1e-06

33% (48/143)

GO:0004872|receptor activity|IEA; GO:0005215|transporter activity|IEA; GO:0005764|lysosome|IEA; GO:0006810|transport|IEA; GO:0016020|membrane|IEA

ACL00000784

5-aminolevulinic acid dehydratase related cluster

154

2e-50

65% (32/49)

4.2.1.24

Coenzyme transport and metabolism

Porphyrin and chlorophyll metabolism

GO:0004655|porphobilinogen synthase activity|IEA; GO:0006779|porphyrin biosynthesis|IEA; GO:0006783|heme biosynthesis|IEA; GO:0016829|lyase activity|IEA

ACL00000785

Putative UDP-glucose 4-epimerase related cluster

134

2e-07

28% (53/184)

ACL00000787

unclassified

ACL00000788

Putative enoyl-CoA hydratase protein related cluster

463

2e-45

42% (100/233)

4.2.1.17

Lipid transport and metabolism

Benzoate degradation via CoA ligation Butanoate metabolism Fatty acid biosynthesis (path 2) Fatty acid metabolism Limonene and pinene degradation Lysine degradation Propanoate metabolism Tryptophan metabolism Valine, leucine and isoleucine degradation beta-Alanine metabolism

GO:0003824|catalytic activity|IEA; GO:0004300|enoyl-CoA hydratase activity|IEA; GO:0008152|metabolism|IEA; GO:0016829|lyase activity|IEA

ACL00000790

Indolepyruvate decarboxylase, putative related cluster

423

6e-41

44% (89/199)

ACL00000791

40S ribosomal protein S26 related cluster

303

2e-27

74% (55/74)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000792

Ribosomal protein L7AE-like related cluster

441

5e-43

72% (89/123)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000793

Spopl1

POZ 56 protein homolog related cluster

126

7e-07

31% (31/99)

GO:0005515|protein binding|IEA

ACL00000802

Actin bundling protein related cluster

925

8e-99

67% (188/277)

ACL00000805

P2C1

Protein phosphatase 2C homolog 1 related cluster

534

2e-53

42% (111/261)

3.1.3.16

Signal transduction mechanisms

GO:0000001|mitochondrion inheritance|IMP; GO:0000173|inactivation of MAPK during osmolarity sensing|IDA; GO:0000287|magnesium ion binding|IEA; GO:0003824|catalytic activity|IEA; GO:0004721|phosphoprotein phosphatase activity|IEA; GO:0004722|protein serine/threonine phosphatase activity|IEA; GO:0005634|nucleus|IDA; GO:0005737|cytoplasm|IDA; GO:0006388|tRNA splicing|IMP; GO:0006457|protein folding|IEA; GO:0006470|protein amino acid dephosphorylation|IDA; GO:0006470|protein amino acid dephosphorylation|IEA; GO:0006986|response to unfolded protein|IEA; GO:0008287|protein serine/threonine phosphatase complex|IEA; GO:0015071|protein phosphatase type 2C activity|IDA; GO:0016787|hydrolase activity|IEA; GO:0030145|manganese ion binding|IEA

ACL00000812

unclassified

ACL00000813

Nucleolar protein C7C related cluster

271

2e-23

41% (57/136)

ACL00000814

PSA3

Proteasome subunit alpha type 3 related cluster

166

2e-11

91% (33/36)

3.4.25.1

Posttranslational modification, protein turnover, chaperones

Proteasome

GO:0004175|endopeptidase activity|IEA; GO:0005829|cytosol|IEA; GO:0005839|proteasome core complex (sensu Eukaryota)|IEA; GO:0006511|ubiquitin-dependent protein catabolism|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00000815

Delta-12 oleate desaturase related cluster

193

1e-14

60% (38/63)

1.14.99.-

Lipid transport and metabolism

1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) degradation Androgen and estrogen metabolism Benzoate degradation via hydroxylation Nicotinate and nicotinamide metabolism

GO:0006633|fatty acid biosynthesis|IEA; GO:0006636|fatty acid desaturation|IEA; GO:0008610|lipid biosynthesis|IEA; GO:0016020|membrane|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016717|oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water|IEA; GO:0050184|phosphatidylcholine desaturase activity|IEA

ACL00000816

ATPD

ATP synthase delta chain, mitochondrial precursor related cluster

251

3e-21

40% (63/154)

3.6.3.14

Energy production and conversion

ATP synthesis Oxidative phosphorylation Photosynthesis

GO:0005739|mitochondrion|IEA; GO:0006754|ATP biosynthesis|IEA; GO:0015078|hydrogen ion transporter activity|IEA; GO:0015986|ATP synthesis coupled proton transport|IEA; GO:0015992|proton transport|IEA; GO:0016469|proton-transporting two-sector ATPase complex|IEA; GO:0016787|hydrolase activity|IEA; GO:0046933|hydrogen-transporting ATP synthase activity, rotational mechanism|IEA; GO:0046961|hydrogen-transporting ATPase activity, rotational mechanism|IEA

ACL00000817

Cell division-like protein related cluster

173

2e-12

85% (34/40)

2.1.1.-

GO:0000910|cytokinesis|IEA

ACL00000819

unclassified

ACL00000821

unclassified

ACL00000822

unclassified

ACL00000823

Translationally controlled tumor protein homolog related cluster

307

2e-27

42% (70/164)

GO:0005554|molecular_function unknown|IEA; GO:0005737|cytoplasm|IEA; GO:0006457|protein folding|IEA; GO:0051082|unfolded protein binding|IEA

ACL00000824

KCY

Cytidylate kinase related cluster

637

1e-65

63% (120/188)

2.7.4.14

Nucleotide transport and metabolism

GO:0004127|cytidylate kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006221|pyrimidine nucleotide biosynthesis|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA; GO:0016776|phosphotransferase activity, phosphate group as acceptor|IEA

ACL00000825

Myosin I heavy chain kinase related cluster

340

1e-31

98% (64/65)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00000826

unclassified

ACL00000827

F-actin capping protein alpha subunit related cluster

850

3e-90

56% (154/274)

GO:0003779|actin binding|IEA; GO:0008290|F-actin capping protein complex|IEA; GO:0030036|actin cytoskeleton organization and biogenesis|IEA

ACL00000828

PSB2

Proteasome subunit beta type 2 related cluster

303

2e-27

59% (58/97)

3.4.25.1

Posttranslational modification, protein turnover, chaperones

Proteasome

GO:0004175|endopeptidase activity|IEA; GO:0005829|cytosol|IEA; GO:0005839|proteasome core complex (sensu Eukaryota)|IEA; GO:0006511|ubiquitin-dependent protein catabolism|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00000829

40S ribosomal protein S5-2 related cluster

304

6e-81

79% (57/72)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0015935|small ribosomal subunit|IEA

ACL00000830

Usp domain containing protein

223

5e-19

32% (49/152)

ACL00000831

unclassified

ACL00000832

Ras-like GTP-binding protein YPT1 related cluster

512

4e-51

50% (101/201)

General function prediction only

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00000833

unclassified

ACL00000834

unclassified

ACL00000835

TIEG2

Transforming growth factor-beta-inducible early growth response protein 2 related cluster

134

8e-08

59% (22/37)

GO:0000122|negative regulation of transcription from Pol II promoter|TAS; GO:0003676|nucleic acid binding|IEA; GO:0003677|DNA binding|IEA; GO:0003700|transcription factor activity|TAS; GO:0005634|nucleus|IEA; GO:0005634|nucleus|TAS; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006366|transcription from Pol II promoter|TAS; GO:0008270|zinc ion binding|IEA; GO:0008285|negative regulation of cell proliferation|TAS

ACL00000836

Putative sterol 4-alpha-methyl-oxidase related cluster

141

1e-08

51% (33/64)

1.-.-.-

Lipid transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0008152|metabolism|IEA

ACL00000837

Putative acyl-CoA transferases/carnitine dehydratase related cluster

151

9e-10

34% (31/90)

Energy production and conversion

GO:0008152|metabolism|IEA; GO:0016740|transferase activity|IEA

ACL00000838

60S ribosomal protein L39 related cluster

235

2e-19

85% (42/49)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000840

unclassified

ACL00000842

mgll

mgll; monoglyceride lipase

90

3e-11

52% (18/34)

Lipid transport and metabolism

ACL00000843

unclassified

ACL00000844

unclassified

ACL00000846

unclassified

ACL00000851

SSU rRNA; A.castellanii mature small subunit rRNA gene, complete.

467

0.0

100% (467/467)

ACL00000853

Galactosidase, putative related cluster

136

9e-08

38% (32/84)

GO:0004565|beta-galactosidase activity|IEA; GO:0005529|sugar binding|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0009341|beta-galactosidase complex|IEA

ACL00000854

Putative heat shock protein related cluster

557

2e-56

57% (104/180)

GO:0006457|protein folding|IEA; GO:0006986|response to unfolded protein|IEA; GO:0051082|unfolded protein binding|IEA

ACL00000855

unclassified

ACL00000856

DUF1077 domain containing protein

299

8e-28

37% (62/167)

ACL00000857

TGF-beta receptor-interacting protein 1 related cluster

746

5e-78

48% (140/291)

GO:0004872|receptor activity|IEA

ACL00000858

unclassified

ACL00000859

unclassified

ACL00000860

Probable acetyl-CoA acetyltransferase related cluster

405

3e-39

65% (75/115)

2.3.1.9

Lipid transport and metabolism

Benzoate degradation via CoA ligation Butanoate metabolism Fatty acid biosynthesis (path 2) Fatty acid metabolism Lysine degradation Propanoate metabolism Pyruvate metabolism Synthesis and degradation of ketone bodies Tryptophan metabolism Valine, leucine and isoleucine degradation

GO:0003985|acetyl-CoA C-acetyltransferase activity|IEA; GO:0008415|acyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00000861

unclassified

ACL00000862

ODO2

Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor related cluster

76

4e-33

50% (13/26)

2.3.1.61

Energy production and conversion

Citrate cycle (TCA cycle) Lysine degradation

GO:0004149|dihydrolipoyllysine-residue succinyltransferase activity|IEA; GO:0005739|mitochondrion|IEA; GO:0006091|generation of precursor metabolites and energy|TAS; GO:0006099|tricarboxylic acid cycle|IEA; GO:0008152|metabolism|IEA; GO:0008415|acyltransferase activity|IEA; GO:0016740|transferase activity|IEA; GO:0045252|oxoglutarate dehydrogenase complex|IEA

ACL00000863

unclassified

ACL00000864

Phosphoglycolate phosphatase precursor related cluster

122

2e-06

45% (31/68)

gamma-Hexachlorocyclohexane degradation

GO:0003824|catalytic activity|IEA; GO:0008152|metabolism|IEA; GO:0016787|hydrolase activity|IEA; GO:0016791|phosphoric monoester hydrolase activity|IEA

ACL00000866

unclassified

ACL00000867

unclassified

ACL00000868

unclassified

ACL00000869

unclassified

ACL00000871

Putative urease accessory protein D related cluster

195

2e-14

30% (56/183)

GO:0006807|nitrogen compound metabolism|IEA; GO:0016151|nickel ion binding|IEA

ACL00000872

UB2EC

Ubiquitin-conjugating enzyme X related cluster

420

1e-40

64% (77/120)

6.3.2.19

Posttranslational modification, protein turnover, chaperones

GO:0000910|cytokinesis|IEA; GO:0004840|ubiquitin conjugating enzyme activity|IEA; GO:0004842|ubiquitin-protein ligase activity|IEA; GO:0006464|protein modification|IEA; GO:0006512|ubiquitin cycle|IEA; GO:0007049|cell cycle|IEA; GO:0007067|mitosis|IEA; GO:0016874|ligase activity|IEA

ACL00000873

unclassified

ACL00000874

unclassified

ACL00000875

UBA domain containing protein

91

3e-05

47% (17/36)

ACL00000876

Unassigned protein

ACL00000877

WD-repeat protein An11 homolog related cluster

419

7e-41

67% (76/113)

General function prediction only

GO:0005737|cytoplasm|NR; GO:0007165|signal transduction|TAS

ACL00000878

unclassified

ACL00000879

Herpes_gp2 domain containing protein

115

2e-06

19% (37/192)

ACL00000880

unclassified

ACL00000881

unclassified

ACL00000882

Putative golgi membrane protein related cluster

123

5e-06

22% (44/192)

Intracellular trafficking, secretion, and vesicular transport

ACL00000883

unclassified

ACL00000885

unclassified

ACL00000887

unclassified

ACL00000888

DUF393 domain containing protein

121

3e-07

29% (23/79)

ACL00000889

unclassified

ACL00000890

Putative alcohol dehydrogenase related cluster

644

3e-66

45% (134/293)

ACL00000891

unclassified

ACL00000892

Unassigned protein

123

4e-06

29% (33/113)

ACL00000893

Putative rac GTPase activating protein related cluster

169

7e-12

34% (37/106)

ACL00000895

unclassified

ACL00000896

unclassified

ACL00000897

unclassified

ACL00000898

Unassigned protein

190

3e-14

57% (39/68)

ACL00000899

unclassified

ACL00000901

hspC

Small heat shock protein related cluster

199

1e-14

38% (35/91)

Posttranslational modification, protein turnover, chaperones

GO:0006457|protein folding|IEA; GO:0006986|response to unfolded protein|IEA

ACL00000902

t_SNARE domain containing protein

94

2e-05

25% (17/68)

ACL00000903

Transcription factor APFI related cluster

487

3e-48

46% (97/210)

ACL00000904

unclassified

ACL00000905

unclassified

ACL00000906

Unassigned protein

144

8e-09

29% (41/139)

ACL00000907

IPK domain containing protein

114

4e-07

39% (19/48)

ACL00000908

unclassified

ACL00000909

unclassified

ACL00000910

TT_ORF1 domain containing protein

114

2e-06

30% (26/85)

ACL00000912

unclassified

ACL00000913

unclassified

ACL00000914

Molybdopterin biosynthesis CNX1 protein related cluster

299

6e-27

52% (65/125)

Coenzyme transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0006777|Mo-molybdopterin cofactor biosynthesis|IEA

ACL00000915

guaB

IMP dehydrogenase related cluster

267

3e-23

70% (51/72)

1.1.1.205

Nucleotide transport and metabolism

Purine metabolism

GO:0003824|catalytic activity|IEA; GO:0003938|IMP dehydrogenase activity|IEA; GO:0006164|purine nucleotide biosynthesis|IEA; GO:0006177|GMP biosynthesis|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000916

unclassified

ACL00000917

COG6

COG6; component of oligomeric golgi complex 6

321

3e-29

34% (65/187)

ACL00000918

G protein beta subunit-like protein related cluster

180

1e-12

26% (53/203)

ACL00000919

TT_ORF1 domain containing protein

117

6e-07

42% (25/59)

ACL00000920

unclassified

ACL00000922

DHRSX

Retinol dehydrogenase 12 related cluster

368

3e-34

36% (91/251)

GO:0004745|retinol dehydrogenase activity|ISS; GO:0005615|extracellular space|TAS; GO:0005622|intracellular|ISS; GO:0007601|visual perception|IEA; GO:0007601|visual perception|ISS; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0042572|retinol metabolism|ISS; GO:0045494|photoreceptor maintenance|ISS

ACL00000923

unclassified

ACL00000924

unclassified

ACL00000925

lat

Probable L-lysine-epsilon aminotransferase related cluster

128

4e-07

62% (22/35)

2.6.1.36

Amino acid transport and metabolism

Lysine biosynthesis

ACL00000928

multi-domain protein

124

2e-07

21% (55/255)

ACL00000929

Machado-Joseph disease protein 1 related cluster

305

1e-27

41% (53/127)

GO:0005634|nucleus|IEA; GO:0005654|nucleoplasm|TAS; GO:0005737|cytoplasm|TAS; GO:0006289|nucleotide-excision repair|TAS; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0007268|synaptic transmission|TAS; GO:0007399|neurogenesis|TAS

ACL00000930

unclassified

ACL00000932

unclassified

ACL00000933

unclassified

ACL00000934

Protamine_P1 domain containing protein

112

3e-06

42% (24/57)

ACL00000935

unclassified

ACL00000936

FPPS

Farnesyl pyrophosphate synthetase related cluster

130

2e-07

61% (21/34)

2.5.1.1

Coenzyme transport and metabolism

GO:0004337|geranyltranstransferase activity|IEA; GO:0006695|cholesterol biosynthesis|IEA; GO:0008299|isoprenoid biosynthesis|IEA; GO:0016740|transferase activity|IEA

ACL00000937

unclassified

ACL00000940

Unknown EST

57

6e-06

37% (11/29)

ACL00000941

Ndufa5

NADH-ubiquinone oxidoreductase related cluster

246

3e-20

51% (49/95)

1.6.5.3 1.6.99.3

Oxidative phosphorylation

GO:0005743|mitochondrial inner membrane|IEA; GO:0006118|electron transport|IEA; GO:0016651|oxidoreductase activity, acting on NADH or NADPH|IEA

ACL00000942

PSB3

Proteasome subunit beta type 3 related cluster

670

2e-69

61% (126/205)

3.4.25.1

Posttranslational modification, protein turnover, chaperones

Proteasome

GO:0004175|endopeptidase activity|IEA; GO:0005829|cytosol|IEA; GO:0005839|proteasome core complex (sensu Eukaryota)|IEA; GO:0006511|ubiquitin-dependent protein catabolism|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00000944

unclassified

ACL00000945

Unassigned protein

ACL00000946

Unknown EST

111

6e-06

48% (19/39)

ACL00000947

PSA7

Proteasome subunit alpha type 7 related cluster

714

1e-74

71% (140/195)

3.4.25.1

Posttranslational modification, protein turnover, chaperones

Proteasome

GO:0004175|endopeptidase activity|IEA; GO:0005829|cytosol|IEA; GO:0005839|proteasome core complex (sensu Eukaryota)|IEA; GO:0006511|ubiquitin-dependent protein catabolism|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00000948

[R] COG0790 FOG: TPR repeat, SEL1 subfamily

191

7e-15

36% (46/127)

General function prediction only

ACL00000949

unclassified

ACL00000950

unclassified

ACL00000951

TLP19

Similar to thioredoxin-like protein p19 related cluster

325

1e-29

50% (64/126)

GO:0005489|electron transporter activity|IEA; GO:0006118|electron transport|IEA

ACL00000953

Unknown EST

125

6e-07

32% (21/65)

ACL00000955

TT_ORF1 domain containing protein

110

8e-06

44% (27/61)

ACL00000956

unclassified

ACL00000957

START domain containing protein

133

1e-08

20% (41/199)

ACL00000958

Eif4el3

Eukaryotic translation initiation factor 4E type 3 related cluster

230

1e-18

51% (45/87)

Translation, ribosomal structure and biogenesis

GO:0000339|RNA cap binding|TAS; GO:0003723|RNA binding|IEA; GO:0003743|translation initiation factor activity|IEA; GO:0005737|cytoplasm|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006413|translational initiation|IEA; GO:0006417|regulation of protein biosynthesis|IEA; GO:0006445|regulation of translation|IEA; GO:0006445|regulation of translation|TAS; GO:0008135|translation factor activity, nucleic acid binding|TAS

ACL00000959

unclassified

ACL00000960

RAPB protein related cluster

217

7e-17

53% (41/76)

GO:0003700|transcription factor activity|IEA; GO:0005634|nucleus|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA

ACL00000961

unclassified

ACL00000962

Pept_tRNA_hydro domain containing protein

118

7e-07

24% (33/133)

ACL00000963

Nonhistone chromosomal protein related cluster

219

2e-17

55% (37/67)

GO:0000785|chromatin|IEA; GO:0003677|DNA binding|IEA; GO:0005634|nucleus|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA

ACL00000966

multi-domain protein

132

3e-08

45% (22/48)

ACL00000967

unclassified

ACL00000968

Mago nashi-like protein related cluster

649

3e-67

81% (117/143)

ACL00000969

Glutathione S-transferase related cluster

572

3e-58

61% (112/183)

Posttranslational modification, protein turnover, chaperones

GO:0004364|glutathione transferase activity|IEA

ACL00000970

unclassified

ACL00000972

Putative 32.7 kDa rhodanese-like thiosulfate sulfurtransferase related cluster

282

4e-24

30% (82/269)

2.8.1.1

Inorganic ion transport and metabolism

GO:0004792|thiosulfate sulfurtransferase activity|IEA; GO:0008272|sulfate transport|IEA; GO:0016740|transferase activity|IEA

ACL00000973

F5O11.2; stress-inducible protein, putative

135

5e-08

73% (25/34)

ACL00000974

multi-domain protein

120

5e-07

26% (51/193)

ACL00000975

TT_ORF1 domain containing protein

111

5e-06

41% (34/82)

ACL00000976

multi-domain protein

174

5e-13

21% (74/352)

ACL00000977

S-adenosylmethionine-dependent methyltransferase, putative related cluster

526

8e-53

48% (109/226)

GO:0008168|methyltransferase activity|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00000978

DnaJ homolog subfamily B member 11 precursor related cluster

207

3e-16

44% (41/93)

Posttranslational modification, protein turnover, chaperones

GO:0005783|endoplasmic reticulum|IEA; GO:0006457|protein folding|IEA; GO:0051082|unfolded protein binding|IEA

ACL00000979

unclassified

ACL00000983

AL1A3

Aldehyde dehydrogenase 6 related cluster

552

7e-56

51% (101/197)

1.2.1.5

Energy production and conversion

GO:0004028|aldehyde dehydrogenase activity|TAS; GO:0004030|aldehyde dehydrogenase [NAD(P)+] activity|IEA; GO:0006066|alcohol metabolism|TAS; GO:0006629|lipid metabolism|TAS; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000984

unclassified

ACL00000985

CwfJ_C_1 domain containing protein

225

2e-19

31% (28/88)

ACL00000986

unclassified

ACL00000987

multi-domain protein

117

8e-07

42% (30/70)

ACL00000988

ACLY

ATP-citrate synthase related cluster

1063

1e-115

68% (191/278)

2.3.3.8

Energy production and conversion

Citrate cycle (TCA cycle)

GO:0000287|magnesium ion binding|IEA; GO:0003824|catalytic activity|IEA; GO:0003878|ATP citrate synthase activity|IEA; GO:0003878|ATP citrate synthase activity|TAS; GO:0005524|ATP binding|IEA; GO:0006101|citrate metabolism|TAS; GO:0006200|ATP catabolism|TAS; GO:0008152|metabolism|IEA; GO:0008610|lipid biosynthesis|IEA; GO:0009346|citrate lyase complex|TAS; GO:0015936|coenzyme A metabolism|TAS; GO:0016740|transferase activity|IEA

ACL00000990

unclassified

ACL00000992

unclassified

ACL00000993

WD-repeat protein related cluster

152

5e-16

43% (31/71)

GO:0006952|defense response|IEA; GO:0042829|defense response to pathogen|IEA

ACL00000994

Mrpl12

60S ribosomal protein L7/L12 related cluster

171

2e-11

28% (40/141)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000996

Transitional endoplasmic reticulum ATPase homolog 1 related cluster

327

3e-30

62% (74/118)

Posttranslational modification, protein turnover, chaperones

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0008151||IEA; GO:0016787|hydrolase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

ACL00000997

unclassified

ACL00000998

PSA5

Proteasome subunit alpha type 5 related cluster

708

5e-74

72% (145/201)

3.4.25.1

Posttranslational modification, protein turnover, chaperones

Proteasome

GO:0000502|proteasome complex (sensu Eukaryota)|TAS; GO:0004175|endopeptidase activity|IEA; GO:0005829|cytosol|IEA; GO:0005839|proteasome core complex (sensu Eukaryota)|IEA; GO:0006511|ubiquitin-dependent protein catabolism|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00000999

unclassified

ACL00001000

G10 protein homolog related cluster

613

6e-63

72% (102/141)

GO:0003700|transcription factor activity|TAS; GO:0005554|molecular_function unknown|IEA; GO:0005634|nucleus|IEA; GO:0005634|nucleus|TAS; GO:0006357|regulation of transcription from Pol II promoter|TAS

ACL00001001

unclassified

ACL00001002

Putative eukaryotic initiation factor subunit related cluster

505

4e-50

47% (108/227)

GO:0003723|RNA binding|IEA; GO:0003743|translation initiation factor activity|IEA; GO:0006413|translational initiation|IEA

ACL00001003

unclassified

ACL00001004

DHB4

Peroxisomal multifunctional enzyme type 2 related cluster

436

2e-42

46% (90/194)

1.1.1.35

GO:0003824|catalytic activity|IEA; GO:0003857|3-hydroxyacyl-CoA dehydrogenase activity|IEA; GO:0004303|estradiol 17-beta-dehydrogenase activity|TAS; GO:0005498|sterol carrier activity|IEA; GO:0005498|sterol carrier activity|TAS; GO:0005777|peroxisome|IEA; GO:0005777|peroxisome|TAS; GO:0006631|fatty acid metabolism|IEA; GO:0008152|metabolism|IEA; GO:0015248|sterol transporter activity|TAS; GO:0016491|oxidoreductase activity|IEA; GO:0016829|lyase activity|IEA; GO:0016853|isomerase activity|IEA

ACL00001005

Beta-glucosidase related cluster

389

3e-37

49% (83/169)

Carbohydrate transport and metabolism

GO:0004553|hydrolase activity, hydrolyzing O-glycosyl compounds|IEA; GO:0005975|carbohydrate metabolism|IEA

ACL00001006

Unassigned protein

ACL00001007

unclassified

ACL00001008

Similar to Homo sapiens (Human). MAD2-like protein 1 related cluster

638

3e-65

65% (120/184)

ACL00001009

unclassified

ACL00001010

GCST

Aminomethyltransferase, mitochondrial precursor related cluster

124

1e-06

53% (32/60)

2.1.2.10

Amino acid transport and metabolism

GO:0004047|aminomethyltransferase activity|IEA; GO:0005739|mitochondrion|IEA; GO:0006546|glycine catabolism|IEA; GO:0008483|transaminase activity|IEA; GO:0016740|transferase activity|IEA

ACL00001011

MIL23.11; transducin family protein / WD-40 repeat family protein

365

2e-34

53% (67/125)

General function prediction only

ACL00001012

multi-domain protein

107

7e-06

27% (20/72)

ACL00001013

unclassified

ACL00001015

Putative involvement in cytochrome oxidase assembly related cluster

143

7e-09

47% (30/63)

ACL00001016

p150 target of rapamycin (TOR)-scaffold protein

367

2e-34

40% (81/200)

ACL00001017

unclassified

ACL00001018

Putative pre-mRNA splicing factor related cluster

172

9e-12

27% (60/219)

GO:0005488|binding|IEA; GO:0005622|intracellular|IEA; GO:0006396|RNA processing|IEA

ACL00001019

Phosphorylase kinase alpha subunit related cluster

234

6e-19

47% (58/121)

GO:0005516|calmodulin binding|IEA; GO:0005977|glycogen metabolism|IEA; GO:0016301|kinase activity|IEA

ACL00001020

unclassified

ACL00001022

Molybdenum cofactor biosynthesis protein Cnx1 related cluster

370

7e-35

45% (78/170)

Coenzyme transport and metabolism

GO:0006777|Mo-molybdopterin cofactor biosynthesis|IEA

ACL00001023

Kinesin-like protein related cluster

119

4e-06

51% (18/35)

GO:0000151|ubiquitin ligase complex|IEA; GO:0003774|motor activity|IEA; GO:0004842|ubiquitin-protein ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0005875|microtubule associated complex|IEA; GO:0008270|zinc ion binding|IEA; GO:0016567|protein ubiquitination|IEA

ACL00001024

Replication factor C large subunit-like protein related cluster

159

1e-10

35% (37/105)

Replication, recombination and repair

GO:0000166|nucleotide binding|IEA; GO:0003677|DNA binding|IEA; GO:0005524|ATP binding|IEA; GO:0005622|intracellular|IEA; GO:0005663|DNA replication factor C complex|IEA; GO:0006260|DNA replication|IEA; GO:0006952|defense response|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA; GO:0042829|defense response to pathogen|IEA

ACL00001025

DNA repair protein Rad51 homolog related cluster

75

2e-35

76% (13/17)

GO:0000166|nucleotide binding|IEA; GO:0003677|DNA binding|IEA; GO:0003684|damaged DNA binding|IEA; GO:0005524|ATP binding|IEA; GO:0005622|intracellular|IEA; GO:0006281|DNA repair|IEA; GO:0006310|DNA recombination|IEA; GO:0008094|DNA-dependent ATPase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

ACL00001026

unclassified

ACL00001027

GCH1

GTP cyclohydrolase I related cluster

169

3e-65

64% (31/48)

3.5.4.16

Coenzyme transport and metabolism

Folate biosynthesis

GO:0003824|catalytic activity|IEA; GO:0003934|GTP cyclohydrolase I activity|IEA; GO:0006729|tetrahydrobiopterin biosynthesis|IEA; GO:0009058|biosynthesis|IEA; GO:0016787|hydrolase activity|IEA

ACL00001028

PLDP1

Phospholipase D p1 related cluster

415

9e-40

40% (103/253)

3.1.4.4

GO:0003824|catalytic activity|IEA; GO:0004630|phospholipase D activity|IEA; GO:0008152|metabolism|IEA; GO:0016042|lipid catabolism|IEA; GO:0016787|hydrolase activity|IEA

ACL00001029

PIN1

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 related cluster

405

6e-39

54% (83/153)

5.2.1.8

Posttranslational modification, protein turnover, chaperones

GO:0003755|peptidyl-prolyl cis-trans isomerase activity|IEA; GO:0005515|protein binding|TAS; GO:0005634|nucleus|IEA; GO:0005634|nucleus|TAS; GO:0006457|protein folding|IEA; GO:0007049|cell cycle|IEA; GO:0007088|regulation of mitosis|TAS; GO:0016853|isomerase activity|IEA

ACL00001030

Csrp2

Cysteine and glycine-rich protein 2 related cluster

185

2e-13

46% (29/63)

GO:0005554|molecular_function unknown|ND; GO:0005634|nucleus|IEA; GO:0005634|nucleus|NAS; GO:0007275|development|IEA; GO:0007517|muscle development|NAS; GO:0008270|zinc ion binding|IEA; GO:0008283|cell proliferation|NAS; GO:0009887|organogenesis|NAS; GO:0016049|cell growth|NAS; GO:0030154|cell differentiation|IEA; GO:0030154|cell differentiation|NAS

ACL00001031

unclassified

ACL00001032

PABPC1

Similar to poly(A)-binding protein 1 related cluster

144

6e-09

66% (30/45)

ACL00001033

Purple acid phosphatase-like protein related cluster

212

2e-16

36% (56/152)

GO:0016787|hydrolase activity|IEA

ACL00001034

HIPPO

Serine/threonine-protein kinase hippo related cluster

489

2e-48

50% (96/192)

2.7.1.37

GO:0000122|negative regulation of transcription from Pol II promoter|NAS; GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IDA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|NAS; GO:0005515|protein binding|IEA; GO:0005515|protein binding|NAS; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IDA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0006468|protein amino acid phosphorylation|NAS; GO:0006915|apoptosis|IEA; GO:0006915|apoptosis|IMP; GO:0007165|signal transduction|IEA; GO:0008283|cell proliferation|IMP; GO:0008372|cellular_component unknown|ND; GO:0016740|transferase activity|IEA; GO:0042127|regulation of cell proliferation|TAS; GO:0043065|positive regulation of apoptosis|TAS; GO:0045926|negative regulation of growth|TAS

ACL00001035

Ribosomal protein S16 related cluster

389

6e-37

81% (71/87)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00001036

Arpc4

ARP2/3 complex 20 kDa subunit related cluster

671

2e-69

74% (125/167)

Regulation of actin cytoskeleton

GO:0005856|cytoskeleton|IEA; GO:0030041|actin filament polymerization|IEA

ACL00001037

Putative amino acid transport protein related cluster

182

6e-13

27% (48/174)

Amino acid transport and metabolism

ACL00001038

PGMP

Phosphoglucomutase, chloroplast precursor related cluster

83

4e-13

65% (17/26)

5.4.2.2

Carbohydrate transport and metabolism

Galactose metabolism Glycolysis / Gluconeogenesis Pentose phosphate pathway Starch and sucrose metabolism Streptomycin biosynthesis

GO:0000287|magnesium ion binding|IEA; GO:0004614|phosphoglucomutase activity|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0009507|chloroplast|IEA; GO:0016853|isomerase activity|IEA; GO:0016868|intramolecular transferase activity, phosphotransferases|IEA

ACL00001039

ADP-ribosylation factor 3 related cluster

352

5e-33

53% (80/150)

GO:0005525|GTP binding|IEA; GO:0005794|Golgi apparatus|IEA; GO:0006886|intracellular protein transport|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00001040

multi-domain protein

135

1e-08

26% (60/225)

ACL00001041

PPB

Repressible alkaline phosphatase precursor related cluster

163

2e-10

55% (37/67)

3.1.3.1

Inorganic ion transport and metabolism

Folate biosynthesis Glycerolipid metabolism gamma-Hexachlorocyclohexane degradation

GO:0000287|magnesium ion binding|IEA; GO:0000329|vacuolar membrane (sensu Fungi)|IDA; GO:0004035|alkaline phosphatase activity|IDA; GO:0004035|alkaline phosphatase activity|IEA; GO:0006470|protein amino acid dephosphorylation|IDA; GO:0008152|metabolism|IEA; GO:0016021|integral to membrane|IEA; GO:0016576|histone dephosphorylation|IDA; GO:0016787|hydrolase activity|IEA

ACL00001042

Ribosomal protein L17 related cluster

265

9e-23

53% (53/100)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00001043

Similar to Xenopus laevis (African clawed frog). calcium/calmodulin-dependent protein kinase I alpha related cluster

752

1e-78

50% (158/311)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00001044

Unassigned protein

ACL00001045

Putative oxidoreductase related cluster

286

2e-25

51% (56/108)

GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00001046

unclassified

ACL00001047

Zinc transporter protein ZIP1 related cluster

270

7e-23

29% (90/309)

GO:0005385|zinc ion transporter activity|IEA; GO:0006829|zinc ion transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0030001|metal ion transport|IEA; GO:0046873|metal ion transporter activity|IEA

ACL00001048

GCDH

Glutaryl-CoA dehydrogenase, mitochondrial precursor related cluster

694

3e-72

68% (132/194)

1.3.99.7

Lipid transport and metabolism

Benzoate degradation via CoA ligation Fatty acid metabolism Lysine degradation Tryptophan metabolism

GO:0003995|acyl-CoA dehydrogenase activity|IEA; GO:0004361|glutaryl-CoA dehydrogenase activity|IEA; GO:0005739|mitochondrion|IEA; GO:0006118|electron transport|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00001050

unclassified

ACL00001051

Probable single-stranded DNA-binding protein 68k chain related cluster

261

2e-22

38% (53/139)

Replication, recombination and repair

GO:0003676|nucleic acid binding|IEA; GO:0003677|DNA binding|IEA; GO:0005634|nucleus|IEA; GO:0006260|DNA replication|IEA

ACL00001052

unclassified

ACL00001053

unclassified

ACL00001054

unclassified

ACL00001055

amino acid/polyamine transporter, family II (54.0 kD) (XL883) [Caenorhabditis elegans] emb|CAA97776.2| Hypothetical protein C03A3.2 [Caenorhabditis elegans]

219

5e-17

31% (55/175)

ACL00001056

GTP-binding protein related cluster

454

1e-44

56% (99/175)

Translation, ribosomal structure and biogenesis

GO:0005525|GTP binding|IEA; GO:0005554|molecular_function unknown|IEA

ACL00001057

Bap31 domain containing protein

209

2e-17

25% (50/200)

ACL00001058

unclassified

ACL00001059

yecM

Putative cytoplasmic protein related cluster

134

2e-07

31% (49/157)

ACL00001061

Putative dehydrogenase related cluster

616

5e-63

52% (133/255)

GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00001062

Adenylyl cyclase-associated protein related cluster

471

2e-46

57% (88/154)

GO:0003779|actin binding|IEA; GO:0016020|membrane|IEA

ACL00001064

unclassified

ACL00001065

Putative CMF receptor CMFR1 related cluster

384

2e-36

48% (70/143)

GO:0004497|monooxygenase activity|IEA; GO:0004872|receptor activity|IEA; GO:0006118|electron transport|IEA; GO:0006725|aromatic compound metabolism|IEA; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00001068

Putative phosphotransferase related cluster

80

1e-27

50% (15/30)

Translation, ribosomal structure and biogenesis

GO:0006388|tRNA splicing|IEA; GO:0016772|transferase activity, transferring phosphorus-containing groups|IEA

ACL00001070

6-phosphogluconate dehydrogenase, decarboxylating related cluster

1417

1e-155

59% (265/447)

1.1.1.44

Carbohydrate transport and metabolism

Pentose phosphate pathway

GO:0004616|phosphogluconate dehydrogenase (decarboxylating) activity|IEA; GO:0006098|pentose-phosphate shunt|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00001071

Gtpbp4

Probable nucleolar GTP-binding protein 1 related cluster

276

3e-24

76% (51/67)

General function prediction only

GO:0005525|GTP binding|IEA; GO:0005634|nucleus|IEA; GO:0007046|ribosome biogenesis|IEA

ACL00001072

unclassified

ACL00001073

unclassified

ACL00001074

Alpha-centractin related cluster

1205

1e-131

65% (232/352)

GO:0003774|motor activity|IEA; GO:0005198|structural molecule activity|IEA; GO:0005200|structural constituent of cytoskeleton|IEA; GO:0005856|cytoskeleton|IEA; GO:0005884|actin filament|IEA; GO:0015629|actin cytoskeleton|IEA

ACL00001075

unclassified

ACL00001076

multi-domain protein

127

1e-07

21% (56/257)

ACL00001077

unclassified

ACL00001079

T-complex protein 1, alpha subunit related cluster

401

1e-115

63% (80/126)

GO:0005524|ATP binding|IEA; GO:0005753|proton-transporting ATP synthase complex (sensu Eukaryota)|NAS; GO:0006457|protein folding|IEA; GO:0008553|hydrogen-exporting ATPase activity, phosphorylative mechanism|NAS; GO:0051082|unfolded protein binding|IEA

ACL00001080

unclassified

ACL00001081

unclassified

ACL00001082

Glutaredoxin-like protein related cluster

110

5e-22

53% (17/32)

Posttranslational modification, protein turnover, chaperones

GO:0005489|electron transporter activity|IEA; GO:0006118|electron transport|IEA

ACL00001083

Lysozyme II precursor related cluster

304

5e-27

38% (71/183)

ACL00001084

Chloroplast 50S ribosomal protein L22, putative, 25606-24374 related cluster

177

4e-12

31% (52/165)

Translation, ribosomal structure and biogenesis

GO:0003723|RNA binding|IEA; GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0015934|large ribosomal subunit|IEA; GO:0019843|rRNA binding|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00001085

Unassigned protein

ACL00001086

Cab39

Cab39; calcium binding protein 39

534

1e-53

46% (105/225)

ACL00001087

multi-domain protein

133

8e-11

45% (15/33)

ACL00001088

unclassified

ACL00001089

putative vesicular transport and membrane fusion protein

Vesicular-fusion protein SEC18 homolog related cluster

272

2e-23

36% (58/158)

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0005794|Golgi apparatus|IEA; GO:0006810|transport|IEA; GO:0015031|protein transport|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

ACL00001092

CCT chaperonin alpha subunit related cluster

413

8e-40

58% (90/153)

Posttranslational modification, protein turnover, chaperones

GO:0005524|ATP binding|IEA; GO:0006457|protein folding|IEA; GO:0051082|unfolded protein binding|IEA

ACL00001093

PI3_PI4_kinase domain containing protein

117

8e-07

22% (29/127)

ACL00001094

unclassified

ACL00001095

unclassified

ACL00001097

unclassified

ACL00001098

Methlytransferase, UbiE/COQ5 family related cluster

230

3e-18

25% (61/241)

GO:0008168|methyltransferase activity|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA

ACL00001099

GDI domain containing protein

102

4e-06

77% (17/22)

ACL00001100

DNCI1

Dynein intermediate chain 1, cytosolic related cluster

131

2e-07

60% (23/38)

GO:0003774|motor activity|IEA; GO:0003774|motor activity|TAS; GO:0005868|cytoplasmic dynein complex|TAS; GO:0030286|dynein complex|IEA

ACL00001101

unclassified

ACL00001102

unclassified

ACL00001103

unclassified

ACL00001104

unclassified

ACL00001106

ATP-synt domain containing protein

114

2e-06

30% (23/75)

ACL00001107

unclassified

ACL00001108

Indole-3-pyruvate decarboxylase related cluster

222

9e-18

37% (57/154)

4.1.1.1

Tryptophan metabolism

GO:0016829|lyase activity|IEA; GO:0047434|indolepyruvate decarboxylase activity|IEA

ACL00001109

unclassified

ACL00001110

arpc1a

Similar to actin related protein 2/3 complex, subunit 1B related cluster

608

4e-62

46% (120/257)

ACL00001111

CG5649

Drosophila melanogaster KIN17 protein related cluster

324

7e-30

61% (56/91)

ACL00001112

39s ribosomal protein L47, mitochondrial precursor related cluster

179

1e-12

41% (41/100)

GO:0003735|structural constituent of ribosome|IEA; GO:0005739|mitochondrion|IEA

ACL00001113

unclassified

ACL00001114

Unknown EST

363

9e-41

81% (76/93)

ACL00001115

unclassified

ACL00001116

unclassified

ACL00001117

Phosphoprotein phosphatase A related cluster

97

8e-39

51% (17/33)

GO:0005488|binding|IEA

ACL00001118

Adhfe1

Alcohol dehydrogenase 8 related cluster

184

1e-13

59% (32/54)

Energy production and conversion

GO:0005506|iron ion binding|IEA; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00001119

Zinc finger protein HRX related cluster

73

1e-06

50% (13/26)

GO:0003677|DNA binding|IEA; GO:0003700|transcription factor activity|NAS; GO:0003702|RNA polymerase II transcription factor activity|TAS; GO:0005634|nucleus|IEA; GO:0005634|nucleus|TAS; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006366|transcription from Pol II promoter|TAS; GO:0008151||IEA; GO:0008270|zinc ion binding|IEA

ACL00001120

Cytosolic aldolase related cluster

238

1e-103

61% (46/75)

Carbohydrate transport and metabolism

GO:0004332|fructose-bisphosphate aldolase activity|IEA; GO:0006096|glycolysis|IEA; GO:0016829|lyase activity|IEA

ACL00001121

26S proteasome regulatory subunit S2 related cluster

340

1e-31

68% (67/98)

Posttranslational modification, protein turnover, chaperones

Proteasome

GO:0000074|regulation of cell cycle|IEA; GO:0005488|binding|IEA; GO:0005829|cytosol|IEA

ACL00001122

26S proteasome non-ATPase regulatory subunit 10 related cluster

214

4e-17

36% (50/136)

GO:0000502|proteasome complex (sensu Eukaryota)|TAS; GO:0005829|cytosol|IEA; GO:0005838|proteasome regulatory particle (sensu Eukaryota)|TAS

ACL00001123

Napa

Beta-soluble NSF attachment protein related cluster

678

3e-70

47% (136/287)

GO:0005478|intracellular transporter activity|IEA; GO:0005488|binding|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0005794|Golgi apparatus|IEA; GO:0006810|transport|IEA; GO:0006886|intracellular protein transport|IEA; GO:0015031|protein transport|IEA

ACL00001124

Unknown EST

125

2e-08

58% (21/36)

ACL00001125

GTP1

Glutathione S-transferase P 1 related cluster

235

4e-19

35% (67/191)

2.5.1.18

Glutathione metabolism

GO:0004364|glutathione transferase activity|IEA; GO:0008152|metabolism|IEA; GO:0016740|transferase activity|IEA

ACL00001126

Proline synthetase co-transcribed bacterial homolog protein related cluster

282

1e-24

47% (68/144)

General function prediction only

GO:0008784|alanine racemase activity|IEA; GO:0030170|pyridoxal phosphate binding|IEA

ACL00001128

unclassified

ACL00001129

unclassified

ACL00001130

unclassified

ACL00001131

Putative ABC transporter related cluster

139

2e-08

44% (22/50)

Defense mechanisms

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0016887|ATPase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

ACL00001133

RAS-related protein racE related cluster

122

6e-06

75% (24/32)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00001135

unclassified

ACL00001136

unclassified

ACL00001137

Coactosin related cluster

167

1e-11

42% (33/77)

GO:0003779|actin binding|IEA; GO:0005622|intracellular|IEA; GO:0005856|cytoskeleton|IEA

ACL00001138

unclassified

ACL00001139

unclassified

ACL00001140

CG11678

Actin-like protein 13E related cluster

58

3e-09

40% (12/30)

GO:0005198|structural molecule activity|IEA; GO:0005200|structural constituent of cytoskeleton|IEA; GO:0005634|nucleus|IEA; GO:0005856|cytoskeleton|IEA; GO:0015629|actin cytoskeleton|IEA

ACL00001141

Mitochondrial phosphate translocator related cluster

632

7e-65

54% (126/230)

GO:0005215|transporter activity|IEA; GO:0005488|binding|IEA; GO:0005743|mitochondrial inner membrane|IEA; GO:0006810|transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA

ACL00001143

[MG] COG0451 Nucleoside-diphosphate-sugar epimerases

120

2e-06

28% (52/185)

ACL00001144

unclassified

ACL00001145

Potassium transport protein 1 related cluster

234

9e-19

31% (63/203)

Inorganic ion transport and metabolism

GO:0006810|transport|IEA; GO:0006812|cation transport|IEA; GO:0006813|potassium ion transport|IEA; GO:0008324|cation transporter activity|IEA; GO:0015079|potassium ion transporter activity|IEA; GO:0016021|integral to membrane|IEA

ACL00001146

unclassified

ACL00001147

unclassified

ACL00001149

Tbcd

Similar to tubulin-specific chaperone D related cluster

140

2e-08

59% (25/42)

GO:0005488|binding|IEA

ACL00001151

TT_ORF1 domain containing protein

109

3e-06

55% (21/38)

ACL00001153

HRMT1L1

Protein arginine N-methyltransferase 2 related cluster

145

2e-59

36% (28/77)

2.1.1.-

Aminophosphonate metabolism Androgen and estrogen metabolism Histidine metabolism Nitrobenzene degradation Selenoamino acid metabolism Tryptophan metabolism Tyrosine metabolism Ubiquinone biosynthesis

GO:0004871|signal transducer activity|TAS; GO:0005634|nucleus|TAS; GO:0006479|protein amino acid methylation|TAS; GO:0007165|signal transduction|TAS; GO:0008168|methyltransferase activity|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00001154

unclassified

ACL00001155

unclassified

ACL00001156

IDHC

Isocitrate dehydrogenase [NADP] cytoplasmic related cluster

112

1e-165

76% (20/26)

1.1.1.42

Energy production and conversion

Citrate cycle (TCA cycle) Glutathione metabolism Reductive carboxylate cycle (CO2 fixation)

GO:0004450|isocitrate dehydrogenase (NADP+) activity|IEA; GO:0004450|isocitrate dehydrogenase (NADP+) activity|TAS; GO:0005777|peroxisome|IEA; GO:0005829|cytosol|TAS; GO:0005975|carbohydrate metabolism|TAS; GO:0006092|main pathways of carbohydrate metabolism|IEA; GO:0006097|glyoxylate cycle|IEA; GO:0006099|tricarboxylic acid cycle|IEA; GO:0006102|isocitrate metabolism|TAS; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00001157

unclassified

ACL00001158

METK

S-adenosylmethionine synthetase related cluster

247

6e-21

100% (44/44)

2.5.1.6

Coenzyme transport and metabolism

GO:0000287|magnesium ion binding|IEA; GO:0004478|methionine adenosyltransferase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006730|one-carbon compound metabolism|IEA; GO:0016740|transferase activity|IEA

ACL00001159

Calreticulin 2 precursor related cluster

605

8e-62

60% (110/183)

GO:0005509|calcium ion binding|IEA; GO:0005529|sugar binding|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0006457|protein folding|IEA; GO:0051082|unfolded protein binding|IEA

ACL00001160

unclassified

ACL00001161

V-ATPase_G domain containing protein

235

1e-20

38% (38/100)

ACL00001163

unclassified

ACL00001164

unclassified

ACL00001165

unclassified

ACL00001166

Proliferating cell nuclear antigen related cluster

236

1e-19

59% (41/69)

GO:0003677|DNA binding|IEA; GO:0005634|nucleus|IEA; GO:0005660|delta-DNA polymerase cofactor complex|IEA; GO:0006260|DNA replication|IEA; GO:0006275|regulation of DNA replication|IEA; GO:0030337|DNA polymerase processivity factor activity|IEA

ACL00001167

unclassified

ACL00001169

Subtilisin-like serine proteinase related cluster

79

4e-80

25% (17/67)

3.4.21.-

Posttranslational modification, protein turnover, chaperones

GO:0004252|serine-type endopeptidase activity|IEA; GO:0004289|subtilase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA; GO:0042802|protein self binding|IEA; GO:0043086|negative regulation of enzyme activity|IEA

ACL00001170

Unknown EST

111

5e-06

60% (21/35)

ACL00001171

unclassified

ACL00001172

Unassigned protein

264

1e-22

36% (58/159)

ACL00001173

unclassified

ACL00001174

unclassified

ACL00001175

unclassified

ACL00001176

unclassified

ACL00001177

unclassified

ACL00001178

Alternative oxidase related cluster

74

8e-39

43% (14/32)

GO:0005740|mitochondrial membrane|IEA; GO:0007585|respiratory gaseous exchange|IEA

ACL00001179

unclassified

ACL00001180

unclassified

ACL00001181

Unassigned protein

ACL00001182

unclassified

ACL00001183

unclassified

ACL00001184

Gelation factor related cluster

779

1e-81

44% (161/360)

GO:0003779|actin binding|IEA

ACL00001185

unclassified

ACL00001186

Transitional endoplasmic reticulum ATPase homolog 1 related cluster

128

4e-07

45% (18/40)

Posttranslational modification, protein turnover, chaperones

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0008151||IEA; GO:0016787|hydrolase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

ACL00001190

multi-domain protein

160

2e-11

21% (66/314)

ACL00001191

RPL36

60S ribosomal protein L36 related cluster

209

2e-16

47% (46/97)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0003735|structural constituent of ribosome|NAS; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0005842|cytosolic large ribosomal subunit (sensu Eukaryota)|NAS; GO:0006412|protein biosynthesis|IEA; GO:0006412|protein biosynthesis|NAS

ACL00001192

unclassified

ACL00001197

Unknown EST

192

1e-16

100% (40/40)

ACL00001198

unclassified

ACL00001199

26s protease regulatory subunit s10b related cluster

302

1e-134

67% (57/84)

Posttranslational modification, protein turnover, chaperones

Proteasome

GO:0005524|ATP binding|IEA; GO:0005634|nucleus|IEA; GO:0005737|cytoplasm|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA; GO:0030163|protein catabolism|IEA

ACL00001200

unclassified

ACL00001202

unclassified

ACL00001203

Herpes_gp2 domain containing protein

112

5e-06

25% (36/142)

ACL00001204

Acetyl/propionyl-CoA carboxylase, alpha subunit related cluster

116

1e-05

54% (26/48)

GO:0004075|biotin carboxylase activity|IEA; GO:0005524|ATP binding|IEA; GO:0008152|metabolism|IEA; GO:0009374|biotin binding|IEA; GO:0016874|ligase activity|IEA

ACL00001205

Putative MAGE related cluster

123

2e-06

34% (28/82)

ACL00001206

Similar to Dictyostelium discoideum (Slime mold). Pats1 related cluster

208

7e-16

32% (58/180)

GO:0004672|protein kinase activity|IEA; GO:0004713|protein-tyrosine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00001207

unclassified

ACL00001208

unclassified

ACL00001209

RPA4

DNA-dependent RNA polymerase 19 kDa polypeptide related cluster

136

5e-08

40% (25/61)

2.7.7.6

GO:0003677|DNA binding|IEA; GO:0003899|DNA-directed RNA polymerase activity|IC; GO:0003899|DNA-directed RNA polymerase activity|IEA; GO:0005634|nucleus|IEA; GO:0006350|transcription|IEA; GO:0016740|transferase activity|IEA

ACL00001210

unclassified

ACL00001211

unclassified

ACL00001212

Odz3

Odz3; odd Oz/ten-m homolog 3 (Drosophila)

162

7e-11

45% (29/64)

ACL00001213

tuf-1

Translation elongation factor Tu related cluster

841

5e-89

54% (161/293)

3.6.5.3

Translation, ribosomal structure and biogenesis

GO:0003746|translation elongation factor activity|IEA; GO:0005525|GTP binding|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006414|translational elongation|IEA

ACL00001215

unclassified

ACL00001216

unclassified

ACL00001217

multi-domain protein

157

3e-11

34% (53/155)

ACL00001218

unclassified

ACL00001220

Keratin_B2 domain containing protein

127

1e-07

22% (34/150)

ACL00001221

unclassified

ACL00001223

Lung seven transmembrane receptor 1 related cluster

266

4e-23

60% (47/78)

GO:0004872|receptor activity|IEA; GO:0016021|integral to membrane|IEA

ACL00001224

unclassified

ACL00001225

unclassified

ACL00001226

unclassified

ACL00001227

Unassigned protein

132

5e-07

42% (39/91)

ACL00001228

Chaperonin CPN60-1, mitochondrial precursor related cluster

145

4e-09

76% (32/42)

Posttranslational modification, protein turnover, chaperones

GO:0005524|ATP binding|IEA; GO:0005739|mitochondrion|IEA; GO:0006457|protein folding|IEA; GO:0006986|response to unfolded protein|IEA; GO:0051082|unfolded protein binding|IEA

ACL00001229

TPP1

Tripeptidyl-peptidase I precursor related cluster

148

2e-09

43% (38/88)

3.4.14.9

GO:0004252|serine-type endopeptidase activity|IEA; GO:0005764|lysosome|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA; GO:0019131|tripeptidyl-peptidase I activity|IEA

ACL00001230

Wdr5

WD-repeat protein 5 related cluster

92

8e-10

65% (19/29)

General function prediction only

ACL00001231

ilvE

Branched-chain amino acid aminotransferase related cluster

329

8e-30

31% (79/253)

2.6.1.42

Pantothenate and CoA biosynthesis Valine, leucine and isoleucine biosynthesis Valine, leucine and isoleucine degradation

GO:0003824|catalytic activity|IEA; GO:0004084|branched-chain-amino-acid transaminase activity|IEA; GO:0008152|metabolism|IEA; GO:0009081|branched chain family amino acid metabolism|IEA

ACL00001232

CG1637

CG1637; CG1637 gene product from transcript CG1637-RA

77

7e-07

46% (13/28)

ACL00001234

Similar to Fugu rubripes (Japanese pufferfish) (Takifugu rubripes). dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial related cluster

207

6e-16

40% (47/117)

2.3.1.61

Energy production and conversion

Citrate cycle (TCA cycle) Lysine degradation

GO:0004149|dihydrolipoyllysine-residue succinyltransferase activity|IEA; GO:0006099|tricarboxylic acid cycle|IEA; GO:0008152|metabolism|IEA; GO:0008415|acyltransferase activity|IEA; GO:0016740|transferase activity|IEA; GO:0045252|oxoglutarate dehydrogenase complex|IEA

ACL00001235

unclassified

ACL00001236

unclassified

ACL00001237

F9E11.8; kelch repeat-containing protein

195

4e-15

32% (47/144)

ACL00001238

Unassigned protein

75

3e-06

60% (14/23)

ACL00001239

Protein kinase C inhibitor related cluster

286

2e-25

54% (58/107)

GO:0016301|kinase activity|IEA

ACL00001240

Unknown EST

108

8e-06

80% (21/26)

ACL00001241

Unassigned protein

182

4e-13

39% (37/94)

ACL00001242

unclassified

ACL00001243

unclassified

ACL00001244

unclassified

ACL00001245

VERM

Tryptophan 2,3-dioxygenase related cluster

402

1e-38

52% (82/157)

1.13.11.11

Amino acid transport and metabolism

Tryptophan metabolism

GO:0004833|tryptophan 2,3-dioxygenase activity|IEA; GO:0006568|tryptophan metabolism|IEA; GO:0006727|ommochrome biosynthesis|IMP; GO:0016491|oxidoreductase activity|IEA; GO:0016702|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|IEA

ACL00001246

unclassified

ACL00001247

Unassigned protein

165

1e-10

27% (48/176)

ACL00001248

F14O23.22; transducin family protein / WD-40 repeat family protein

211

4e-16

25% (53/212)

General function prediction only

ACL00001250

Predicted nucleotide-binding protein related to universal stress protein UspA related cluster

91

6e-10

30% (22/73)

Signal transduction mechanisms

GO:0006950|response to stress|IEA

ACL00001251

hspa9b

Organellar heat shock protein related cluster

599

3e-61

63% (122/192)

GO:0005524|ATP binding|IEA; GO:0006457|protein folding|IEA; GO:0006986|response to unfolded protein|IEA

ACL00001252

unclassified

ACL00001253

PSA3

Proteasome subunit alpha type 3 related cluster

987

1e-106

95% (194/204)

3.4.25.1

Posttranslational modification, protein turnover, chaperones

Proteasome

GO:0004175|endopeptidase activity|IEA; GO:0005829|cytosol|IEA; GO:0005839|proteasome core complex (sensu Eukaryota)|IEA; GO:0006511|ubiquitin-dependent protein catabolism|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00001254

[U] COG5158 Proteins involved in synaptic transmission and general secretion, Sec1 family

216

2e-17

29% (63/212)

Intracellular trafficking, secretion, and vesicular transport

ACL00001255

unclassified

ACL00001256

Betaine aldehyde dehydrogenase, putative related cluster

202

1e-15

44% (41/92)

Energy production and conversion

GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00001257

Unassigned protein

ACL00001258

Unassigned protein

131

2e-07

33% (31/93)

ACL00001259

DCUP

Uroporphyrinogen decarboxylase related cluster

648

5e-67

62% (120/193)

4.1.1.37

Coenzyme transport and metabolism

Porphyrin and chlorophyll metabolism

GO:0004853|uroporphyrinogen decarboxylase activity|IEA; GO:0004853|uroporphyrinogen decarboxylase activity|TAS; GO:0006779|porphyrin biosynthesis|IEA; GO:0006783|heme biosynthesis|IEA; GO:0016829|lyase activity|IEA; GO:0016831|carboxy-lyase activity|IEA

ACL00001260

unclassified

ACL00001261

Unknown EST

64

3e-08

33% (12/36)

ACL00001262

ERG4

Probable sterol C-24 reductase related cluster

189

3e-14

45% (40/87)

1.3.1.71

GO:0016020|membrane|IEA

ACL00001263

Autoantigen related cluster

392

3e-37

39% (86/220)

GO:0008537|proteasome activator complex|IEA; GO:0008538|proteasome activator activity|IEA

ACL00001265

unclassified

ACL00001266

Arm repeat protein related cluster

129

7e-07

33% (37/112)

GO:0000151|ubiquitin ligase complex|IEA; GO:0004842|ubiquitin-protein ligase activity|IEA; GO:0005488|binding|IEA; GO:0016567|protein ubiquitination|IEA

ACL00001267

Cation transporting ATPase related cluster

174

2e-12

35% (30/84)

Inorganic ion transport and metabolism

GO:0005524|ATP binding|IEA; GO:0006812|cation transport|IEA; GO:0015662|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016787|hydrolase activity|IEA; GO:0016887|ATPase activity|IEA

ACL00001268

PSA6

Proteasome subunit alpha type 6 related cluster

778

6e-82

63% (150/235)

3.4.25.1

Posttranslational modification, protein turnover, chaperones

Proteasome

GO:0004175|endopeptidase activity|IEA; GO:0005829|cytosol|IEA; GO:0005839|proteasome core complex (sensu Eukaryota)|IEA; GO:0006511|ubiquitin-dependent protein catabolism|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00001269

unclassified

ACL00001270

unclassified

ACL00001271

Cell division control protein 42 homolog related cluster

142

9e-09

70% (26/37)

GO:0000910|cytokinesis|IEA; GO:0005525|GTP binding|IEA; GO:0007049|cell cycle|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0009405|pathogenesis|IEA

ACL00001273

CBS domain protein related cluster

89

4e-08

25% (30/116)

General function prediction only

ACL00001274

unclassified

ACL00001275

unclassified

ACL00001276

unclassified

ACL00001277

unclassified

ACL00001278

unclassified

ACL00001279

[K] COG5190 TFIIF-interacting CTD phosphatases, including NLI-interacting factor

194

9e-15

36% (46/127)

Transcription

ACL00001280

Protein disulfide-isomerase related cluster

382

5e-36

51% (79/153)

GO:0005489|electron transporter activity|IEA; GO:0006118|electron transport|IEA; GO:0016853|isomerase activity|IEA

ACL00001281

Putative secreted hydrolase related cluster

125

1e-06

30% (42/138)

GO:0016787|hydrolase activity|IEA

ACL00001282

KRAS2

Ras-like protein rasD related cluster

52

6e-37

52% (9/17)

MAPK signaling pathway Regulation of actin cytoskeleton

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00001283

Similar to Pyrococcus furiosus. partial alanyl-tRNA synthetase matches COOH terminus related cluster

239

5e-20

47% (44/92)

General function prediction only

GO:0004812|tRNA ligase activity|IEA

ACL00001284

Similar to Arabidopsis thaliana (Mouse-ear cress). phosphonopyruvate decarboxylase-like protein related cluster

52

1e-106

56% (9/16)

GO:0003824|catalytic activity|IEA; GO:0046872|metal ion binding|IEA

ACL00001285

unclassified

ACL00001288

DUF887 domain containing protein

133

2e-08

19% (43/220)

ACL00001289

multi-domain protein

143

6e-10

26% (31/119)

ACL00001290

AKIN gamma related cluster

271

5e-23

27% (89/325)

ACL00001291

unclassified

ACL00001292

unclassified

ACL00001293

Similar to katanin p80 (WD40-containing) subunit B 1 related cluster

145

6e-09

25% (38/147)

General function prediction only

ACL00001294

unclassified

ACL00001295

unclassified

ACL00001296

unclassified

ACL00001297

unclassified

ACL00001298

NONCLATHRIN coat protein gamma - like protein related cluster

168

6e-33

54% (28/51)

Intracellular trafficking, secretion, and vesicular transport

GO:0005488|binding|IEA

ACL00001299

unclassified

ACL00001301

ADP_ribosyl_GH domain containing protein

115

1e-06

29% (20/68)

ACL00001303

unclassified

ACL00001304

TXNRD1

Thioredoxin glutathione reductase related cluster

266

4e-23

71% (45/63)

1.8.1.9

Pyrimidine metabolism

GO:0005489|electron transporter activity|IEA; GO:0005737|cytoplasm|IEA; GO:0006118|electron transport|IEA; GO:0015036|disulfide oxidoreductase activity|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016654|oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor|IEA; GO:0050660|FAD binding|IEA

ACL00001305

CG10849

Synaptic glycoprotein SC2 related cluster

633

6e-65

54% (128/233)

GO:0016021|integral to membrane|IEA

ACL00001306

Similar to Dictyostelium discoideum (Slime mold). GrfA related cluster

217

3e-17

37% (55/145)

ACL00001307

Putative bacterioferritin comigratory protein related cluster

268

7e-23

50% (57/114)

ACL00001308

Aminoalcoholphosphotransferase related cluster

142

1e-08

72% (27/37)

GO:0008654|phospholipid biosynthesis|IEA; GO:0016740|transferase activity|IEA

ACL00001309

HSGP25L2G

Glycoprotein 25L2 precursor related cluster

287

3e-25

39% (67/168)

GO:0005783|endoplasmic reticulum|IEA; GO:0006886|intracellular protein transport|IEA; GO:0008320|protein carrier activity|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA

ACL00001310

Unassigned protein

ACL00001311

VPS28 protein homolog related cluster

198

3e-15

48% (39/81)

GO:0006810|transport|IEA; GO:0015031|protein transport|IEA

ACL00001312

Importin-alpha re-exporter related cluster

125

4e-26

40% (22/54)

Cell cycle control, cell division, chromosome partitioning

GO:0000059|protein-nucleus import, docking|IEA; GO:0005488|binding|IEA; GO:0005634|nucleus|IEA; GO:0005643|nuclear pore|IEA; GO:0005737|cytoplasm|IEA; GO:0006810|transport|IEA; GO:0006915|apoptosis|IEA; GO:0008262|importin-alpha export receptor activity|IEA; GO:0008283|cell proliferation|IEA; GO:0008565|protein transporter activity|IEA; GO:0015031|protein transport|IEA

ACL00001313

DLDH

Dihydrolipoyl dehydrogenase, mitochondrial precursor related cluster

712

3e-74

67% (130/194)

1.8.1.4

Energy production and conversion

GO:0004148|dihydrolipoyl dehydrogenase activity|IDA; GO:0004148|dihydrolipoyl dehydrogenase activity|IEA; GO:0005737|cytoplasm|IEA; GO:0005739|mitochondrion|IEA; GO:0006118|electron transport|IEA; GO:0006546|glycine catabolism|IMP; GO:0006550|isoleucine catabolism|IMP; GO:0006552|leucine catabolism|IMP; GO:0006564|L-serine biosynthesis|IMP; GO:0006574|valine catabolism|IMP; GO:0009353|oxoglutarate dehydrogenase complex (sensu Eukaryota)|IDA; GO:0015036|disulfide oxidoreductase activity|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0042645|mitochondrial nucleoid|IDA; GO:0050660|FAD binding|IEA

ACL00001314

Glycine cleavage system H protein, mitochondrial precursor related cluster

344

1e-31

51% (75/147)

Amino acid transport and metabolism

GO:0005739|mitochondrion|IEA; GO:0005960|glycine cleavage complex|IEA; GO:0006546|glycine catabolism|IEA

ACL00001315

unclassified

ACL00001317

unclassified

ACL00001319

unclassified

ACL00001320

Calmodulin related cluster

72

1e-10

40% (18/44)

Phosphatidylinositol signaling system

GO:0005509|calcium ion binding|IEA

ACL00001323

unclassified

ACL00001324

Similar to Dictyostelium discoideum (Slime mold). GrfA related cluster

150

1e-09

37% (41/108)

ACL00001325

Unassigned protein

ACL00001326

unclassified

ACL00001328

unclassified

ACL00001333

PRDX2

Peroxiredoxin related cluster

675

4e-70

66% (124/186)

1.11.1.-

Posttranslational modification, protein turnover, chaperones

ACL00001334

CG5854

CG5854; CG5854 gene product from transcript CG5854-RA

555

6e-56

40% (120/295)

ACL00001336

6PGD

6-phosphogluconate dehydrogenase, decarboxylating related cluster

216

4e-17

80% (38/47)

1.1.1.44

Carbohydrate transport and metabolism

Pentose phosphate pathway

GO:0004616|phosphogluconate dehydrogenase (decarboxylating) activity|IEA; GO:0005489|electron transporter activity|TAS; GO:0006098|pentose-phosphate shunt|IEA; GO:0009051|pentose-phosphate shunt, oxidative branch|TAS; GO:0016491|oxidoreductase activity|IEA

ACL00001337

Putative GTP-binding protein related cluster

360

5e-34

65% (66/101)

General function prediction only

ACL00001338

unclassified

ACL00001340

Lys domain containing protein

115

1e-06

48% (21/43)

ACL00001341

multi-domain protein

120

5e-07

28% (47/167)

ACL00001343

Rab1

Ras-related protein Rab-1A related cluster

697

2e-72

66% (132/198)

GO:0005525|GTP binding|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0005794|Golgi apparatus|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00001345

Putative inosine-uridine preferring nucleoside hydrolase related cluster

209

1e-15

25% (88/343)

Nucleotide transport and metabolism

GO:0016787|hydrolase activity|IEA

ACL00001348

TRP

Tryptophan synthase related cluster

696

2e-72

56% (140/250)

4.2.1.20

Amino acid transport and metabolism

Phenylalanine, tyrosine and tryptophan biosynthesis

GO:0000162|tryptophan biosynthesis|IEA; GO:0003824|catalytic activity|IEA; GO:0004834|tryptophan synthase activity|IEA; GO:0006568|tryptophan metabolism|IEA; GO:0008152|metabolism|IEA; GO:0016829|lyase activity|IEA

ACL00001349

unclassified

ACL00001351

ENTPD8

Similar to Ca2+-dependent endoplasmic reticulum nucleoside diphosphatase related cluster

270

1e-23

52% (51/97)

3.6.1.6 3.6.1.5

Purine metabolism Pyrimidine metabolism

ACL00001354

Zinc finger transcription factor ZFP30 related cluster

133

1e-07

33% (33/100)

ACL00001355

Nras

Ras-like protein 1 related cluster

607

3e-62

70% (117/165)

MAPK signaling pathway Regulation of actin cytoskeleton

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00001356

unclassified

ACL00001357

Atp6v1h

Putative vacuolar ATPase subunit H protein related cluster

406

9e-39

43% (80/185)

3.6.3.14

Energy production and conversion

ATP synthesis Oxidative phosphorylation

GO:0000221|hydrogen-transporting ATPase V1 domain|IEA; GO:0000300|peripheral to membrane of membrane fraction|IEA; GO:0001671|ATPase stimulator activity|IEA; GO:0005488|binding|IEA; GO:0005524|ATP binding|IEA; GO:0015986|ATP synthesis coupled proton transport|IEA; GO:0046933|hydrogen-transporting ATP synthase activity, rotational mechanism|IEA; GO:0046961|hydrogen-transporting ATPase activity, rotational mechanism|IEA

ACL00001358

RasGAP domain containing protein

113

4e-06

29% (23/79)

ACL00001359

unclassified

ACL00001360

DM6 domain containing protein

90

6e-05

29% (31/105)

ACL00001361

potato_inhibit domain containing protein

142

3e-09

40% (24/59)

ACL00001362

Ras-like protein rasD related cluster

135

6e-08

45% (32/70)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00001364

unclassified

ACL00001365

unclassified

ACL00001366

unclassified

ACL00001367

unclassified

ACL00001368

Unknown EST

128

6e-08

55% (26/47)

ACL00001369

unclassified

ACL00001370

Rbm8

RNA-binding protein 8A related cluster

338

4e-31

46% (67/144)

General function prediction only

GO:0000004|biological_process unknown|ND; GO:0000398|nuclear mRNA splicing, via spliceosome|IEA; GO:0003723|RNA binding|IEA; GO:0003729|mRNA binding|NAS; GO:0005634|nucleus|IEA; GO:0005634|nucleus|NAS; GO:0005737|cytoplasm|IEA; GO:0005737|cytoplasm|NAS; GO:0006396|RNA processing|IEA; GO:0006397|mRNA processing|IEA; GO:0006406|mRNA-nucleus export|IEA; GO:0006810|transport|IEA

ACL00001371

Cytochrome b5 related cluster

165

4e-11

41% (31/75)

GO:0005792|microsome|IEA; GO:0006118|electron transport|IEA; GO:0016021|integral to membrane|IEA

ACL00001372

unclassified

ACL00001373

unclassified

ACL00001374

unclassified

ACL00001375

unclassified

ACL00001376

ACSL6

Long-chain-fatty-acid--CoA ligase 6 related cluster

176

1e-12

35% (36/102)

6.2.1.3

Lipid transport and metabolism

Fatty acid metabolism

GO:0000287|magnesium ion binding|IEA; GO:0003824|catalytic activity|IEA; GO:0004467|long-chain-fatty-acid-CoA ligase activity|IEA; GO:0004467|long-chain-fatty-acid-CoA ligase activity|NAS; GO:0005741|mitochondrial outer membrane|NAS; GO:0005778|peroxisomal membrane|NAS; GO:0005792|microsome|NAS; GO:0005886|plasma membrane|NAS; GO:0006631|fatty acid metabolism|IEA; GO:0006637|acyl-CoA metabolism|NAS; GO:0008152|metabolism|IEA; GO:0016874|ligase activity|IEA

ACL00001377

DUF298 domain containing protein

319

5e-30

43% (51/117)

ACL00001378

TRUB1

TruB pseudouridine synthase-like protein 1 related cluster

462

3e-45

48% (94/192)

GO:0004730|pseudouridylate synthase activity|IEA; GO:0006396|RNA processing|IEA; GO:0008033|tRNA processing|IEA

ACL00001380

unclassified

ACL00001381

Unassigned protein

124

3e-06

38% (38/99)

ACL00001382

TT_ORF1 domain containing protein

111

9e-06

43% (21/48)

ACL00001383

Metal-dependent phosphohydrolase related cluster

63

2e-24

47% (11/23)

GO:0003824|catalytic activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00001385

ARPC3

ARP2/3 complex 21 kDa subunit related cluster

434

3e-42

54% (84/155)

Regulation of actin cytoskeleton

GO:0005856|cytoskeleton|IEA; GO:0030833|regulation of actin filament polymerization|IEA

ACL00001386

FUMH

Fumarate hydratase, mitochondrial precursor related cluster

264

7e-23

83% (50/60)

4.2.1.2

GO:0003824|catalytic activity|IEA; GO:0004333|fumarate hydratase activity|IEA; GO:0005739|mitochondrion|IEA; GO:0006099|tricarboxylic acid cycle|IEA; GO:0006106|fumarate metabolism|IEA; GO:0016829|lyase activity|IEA; GO:0045239|tricarboxylic acid cycle enzyme complex|IEA

ACL00001387

Similar to Arabidopsis thaliana (Mouse-ear cress). synaptobrevin-like protein related cluster

474

1e-46

50% (95/188)

Intracellular trafficking, secretion, and vesicular transport

ACL00001388

Putative IPP isomerase related cluster

432

1e-41

47% (84/178)

5.3.3.2

Lipid transport and metabolism

Biosynthesis of steroids Terpenoid biosynthesis

GO:0004452|isopentenyl-diphosphate delta-isomerase activity|IEA; GO:0008299|isoprenoid biosynthesis|IEA; GO:0016853|isomerase activity|IEA

ACL00001389

KIAA0218

Putative deoxyribonuclease KIAA0218 related cluster

408

3e-39

43% (80/185)

3.1.21.-

GO:0004518|nuclease activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00001390

unclassified

ACL00001392

Similar to Hordeum vulgare carboxypeptidase D related cluster

199

3e-15

42% (39/91)

GO:0003824|catalytic activity|IEA; GO:0004180|carboxypeptidase activity|IEA; GO:0004185|serine carboxypeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA

ACL00001393

PRNPIP

Prion protein interacting protein 1 related cluster

134

1e-07

35% (34/97)

GO:0004527|exonuclease activity|IEA; GO:0005515|protein binding|IDA; GO:0005622|intracellular|IEA; GO:0005886|plasma membrane|TAS

ACL00001394

Putative SET protein, phospatase 2A inhibitor related cluster

192

1e-13

30% (42/138)

GO:0005634|nucleus|IEA; GO:0006334|nucleosome assembly|IEA

ACL00001396

fabG3

3-oxoacyl-(acyl-carrier protein) reductase related cluster

387

1e-36

39% (101/254)

1.1.1.100

Fatty acid biosynthesis (path 1)

GO:0004316|3-oxoacyl-[acyl-carrier protein] reductase activity|IEA; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00001398

Ras-like protein rasD related cluster

477

8e-47

55% (91/165)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00001399

PCNA_C domain containing protein

145

3e-10

57% (26/45)

ACL00001400

T13L16.5; FAT domain-containing protein / phosphatidylinositol 3- and 4-kinase family protein

250

8e-21

30% (62/205)

ACL00001401

MTM1

Myotubularin related cluster

228

1e-18

39% (50/128)

3.1.3.48

GO:0004721|phosphoprotein phosphatase activity|IEA; GO:0004722|protein serine/threonine phosphatase activity|NAS; GO:0004725|protein tyrosine phosphatase activity|IEA; GO:0004725|protein tyrosine phosphatase activity|NAS; GO:0004725|protein tyrosine phosphatase activity|TAS; GO:0006470|protein amino acid dephosphorylation|IEA; GO:0006470|protein amino acid dephosphorylation|NAS; GO:0006470|protein amino acid dephosphorylation|TAS; GO:0007517|muscle development|TAS; GO:0008151||TAS; GO:0008372|cellular_component unknown|ND; GO:0016787|hydrolase activity|IEA

ACL00001402

unclassified

ACL00001403

Putative peptidyl-prolyl cis-trans isomerase related cluster

263

9e-23

72% (47/65)

5.2.1.8

Posttranslational modification, protein turnover, chaperones

GO:0003755|peptidyl-prolyl cis-trans isomerase activity|IEA; GO:0006457|protein folding|IEA; GO:0016853|isomerase activity|IEA

ACL00001404

CETN2

Centrin 2 related cluster

127

1e-06

26% (39/149)

GO:0000910|cytokinesis|IEA; GO:0005509|calcium ion binding|IEA; GO:0005509|calcium ion binding|NAS; GO:0005813|centrosome|NAS; GO:0007067|mitosis|IEA; GO:0007067|mitosis|NAS

ACL00001405

aroG2, RSc0743

Probable phospho-2-dehydro-3-deoxyheptonate aldolase, PHE-sensitive (DAHP synthetase) protein related cluster

632

4e-65

61% (123/199)

2.5.1.54

Amino acid transport and metabolism

Phenylalanine, tyrosine and tryptophan biosynthesis

GO:0003849|3-deoxy-7-phosphoheptulonate synthase activity|IEA; GO:0009058|biosynthesis|IEA; GO:0009073|aromatic amino acid family biosynthesis|IEA; GO:0016829|lyase activity|IEA

ACL00001406

pfk

pfk; 6-phosphofructokinase [EC:2.7.1.11] [KO:K00850]

644

3e-66

45% (136/297)

2.7.1.11

Carbohydrate transport and metabolism

Fructose and mannose metabolism Galactose metabolism Glycolysis / Gluconeogenesis Pentose phosphate pathway

ACL00001407

nucleotide-sensitive chloride conductance regulator (ICln) family protein [Arabidopsis thaliana] dbj|BAA97193.1| unnamed protein product [Arabidopsis thaliana] gb|AAM66035.1| unknown [Arabidopsis thaliana] dbj|BAC43583.1| unknown protein [Arabidopsis thaliana] gb|AAO63849.1| unknown protein [Arabidopsis thaliana]

156

6e-10

34% (42/121)

ACL00001408

Dimethyladenosine transferase related cluster

453

2e-44

49% (100/201)

Translation, ribosomal structure and biogenesis

GO:0000154|rRNA modification|IEA; GO:0000179|rRNA (adenine-N6,N6-)-dimethyltransferase activity|IEA; GO:0006364|rRNA processing|IEA; GO:0008168|methyltransferase activity|IEA; GO:0008649|rRNA methyltransferase activity|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA; GO:0016433|rRNA (adenine) methyltransferase activity|IEA; GO:0016740|transferase activity|IEA; GO:0046677|response to antibiotic|IEA

ACL00001409

unclassified

ACL00001410

unclassified

ACL00001411

AOF

Amine oxidase [flavin-containing] related cluster

90

1e-20

45% (16/35)

1.4.3.4

Amino acid transport and metabolism

GO:0005739|mitochondrion|IEA; GO:0006118|electron transport|IEA; GO:0008131|amine oxidase activity|IEA; GO:0016021|integral to membrane|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00001412

VATO

Probable vacuolar ATP synthase 20 kDa proteolipid subunit related cluster

404

8e-39

60% (80/132)

3.6.3.14

Energy production and conversion

ATP synthesis Oxidative phosphorylation

GO:0006754|ATP biosynthesis|IEA; GO:0015078|hydrogen ion transporter activity|IEA; GO:0015986|ATP synthesis coupled proton transport|IEA; GO:0015992|proton transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016469|proton-transporting two-sector ATPase complex|IEA; GO:0016787|hydrolase activity|IEA; GO:0046933|hydrogen-transporting ATP synthase activity, rotational mechanism|IEA; GO:0046961|hydrogen-transporting ATPase activity, rotational mechanism|IEA

ACL00001413

unclassified

ACL00001414

Glutathione S-transferase related cluster

471

1e-46

51% (96/186)

Posttranslational modification, protein turnover, chaperones

GO:0003824|catalytic activity|IEA; GO:0005737|cytoplasm|IEA; GO:0009072|aromatic amino acid family metabolism|IEA; GO:0016740|transferase activity|IEA

ACL00001415

unclassified

ACL00001416

DUS12

Dual specificity protein phosphatase 12 related cluster

220

9e-18

36% (41/112)

3.1.3.16

Signal transduction mechanisms

GO:0004721|phosphoprotein phosphatase activity|IEA; GO:0006470|protein amino acid dephosphorylation|IEA; GO:0008138|protein tyrosine/serine/threonine phosphatase activity|IDA; GO:0008138|protein tyrosine/serine/threonine phosphatase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00001417

unclassified

ACL00001419

Putative transformer serine/arginine-rich ribonucleoprotein related cluster

269

6e-23

52% (54/103)

GO:0003723|RNA binding|IEA; GO:0019013|viral nucleocapsid|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00001420

Unassigned protein

ACL00001421

unclassified

ACL00001425

unclassified

ACL00001426

unclassified

ACL00001429

unclassified

ACL00001430

Ras-like protein rasS related cluster

150

1e-09

68% (28/41)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00001431

unclassified

ACL00001432

unclassified

ACL00001434

Frataxin homolog related cluster

235

2e-19

47% (47/99)

Inorganic ion transport and metabolism

GO:0005739|mitochondrion|IEA; GO:0006879|iron ion homeostasis|IEA

ACL00001436

unclassified

ACL00001437

PH domain containing protein

139

2e-09

25% (29/114)

ACL00001438

unclassified

ACL00001439

unclassified

ACL00001440

unclassified

ACL00001442

RWD domain containing protein 1 related cluster

189

1e-13

29% (55/189)

ACL00001444

unclassified

ACL00001445

Putative ubiquitin carboxyl-terminal hydrolase related cluster

143

7e-09

42% (30/71)

GO:0004197|cysteine-type endopeptidase activity|IEA; GO:0004221|ubiquitin thiolesterase activity|IEA; GO:0006511|ubiquitin-dependent protein catabolism|IEA; GO:0016787|hydrolase activity|IEA

ACL00001446

unclassified

ACL00001447

Similar to Drosophila melanogaster (Fruit fly). RE12057p related cluster

162

1e-10

42% (36/84)

ACL00001448

unclassified

ACL00001449

atsC

atsC; short chain dehydrogenase

175

9e-13

40% (50/122)

ACL00001452

tif211

Eukaryotic translation initiation factor 2 alpha subunit related cluster

672

2e-69

48% (131/272)

Translation, ribosomal structure and biogenesis

GO:0003723|RNA binding|IEA; GO:0003743|translation initiation factor activity|IEA; GO:0006412|protein biosynthesis|IEA

ACL00001453

unclassified

ACL00001454

unclassified

ACL00001455

Similar to Mortierella alpina. stearoyl-CoA desaturase related cluster

838

1e-88

45% (148/325)

Lipid transport and metabolism

GO:0004768|stearoyl-CoA 9-desaturase activity|IEA; GO:0005506|iron ion binding|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0006633|fatty acid biosynthesis|IEA; GO:0006636|fatty acid desaturation|IEA; GO:0016020|membrane|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016717|oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water|IEA

ACL00001456

Mpv17

Similar to mouse MPV17 protein related cluster

277

8e-24

34% (65/188)

GO:0005743|mitochondrial inner membrane|IDA; GO:0006067|ethanol metabolism|IMP; GO:0016021|integral to membrane|IEA

ACL00001457

Microtubule associated protein related cluster

298

3e-26

52% (60/114)

ACL00001461

T26I12.100; splicing factor, putative

500

7e-50

61% (94/153)

ACL00001463

unclassified

ACL00001464

F14P22.40; universal stress protein (USP) family protein

206

9e-16

31% (52/166)

Signal transduction mechanisms

ACL00001469

unclassified

ACL00001476

CG9131

KISIR protein related cluster

236

5e-19

34% (57/166)

GO:0003700|transcription factor activity|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA

ACL00001480

unclassified

ACL00001482

unclassified

ACL00001483

[S] COG3803 Uncharacterized protein conserved in bacteria

267

3e-23

34% (68/200)

Function unknown

ACL00001485

Transketolase related cluster

313

3e-28

48% (64/131)

2.2.1.1

Carbohydrate transport and metabolism

Carbon fixation Pentose phosphate pathway

GO:0004802|transketolase activity|IEA

ACL00001486

unclassified

ACL00001488

Unassigned protein

160

8e-11

67% (31/46)

ACL00001489

F21F14.160; O-methyltransferase family 3 protein

86

2e-20

39% (15/38)

General function prediction only

ACL00001490

unclassified

ACL00001491

unclassified

ACL00001492

unclassified

ACL00001493

unclassified

ACL00001494

ybbC [Bacillus subtilis subsp. subtilis str. 168] sp|P40407|YBBC_BACSU Hypothetical protein ybbC precursor (ORF2) pir||I39840 hypothetical protein ybbC - Bacillus subtilis gb|AAA64352.1| 19/20 residue stretch (32-51) identical to N-terminal putative signal sequence of unknown, partly cloned B. subtilis gene.; putative dbj|BAA19498.1| YbbC [Bacillus subtilis] emb|CAB11941.1| ybbC [Bacillus subtilis subsp. subtilis str. 168]

164

1e-10

37% (47/126)

ACL00001495

unclassified

ACL00001496

Cullin domain containing protein

103

3e-06

54% (13/24)

ACL00001497

Similar to yeast BET3 involved in targeting and fusion of ER to golgi transport vesicles related cluster

393

2e-37

47% (87/183)

Intracellular trafficking, secretion, and vesicular transport

ACL00001498

unclassified

ACL00001499

unclassified

ACL00001500

Putative Lon2 protease related cluster

365

1e-34

65% (70/107)

3.4.21.-

Posttranslational modification, protein turnover, chaperones

GO:0000166|nucleotide binding|IEA; GO:0004176|ATP-dependent peptidase activity|IEA; GO:0004252|serine-type endopeptidase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0006510|ATP-dependent proteolysis|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

ACL00001502

D-ribulose-5-phosphate 3-epimerase related cluster

655

1e-67

60% (130/215)

Carbohydrate transport and metabolism

GO:0004750|ribulose-phosphate 3-epimerase activity|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0016853|isomerase activity|IEA

ACL00001503

unclassified

ACL00001504

Histone H2A related cluster

167

1e-11

47% (39/82)

Chromatin structure and dynamics

GO:0000786|nucleosome|IEA; GO:0003677|DNA binding|IEA; GO:0005634|nucleus|IEA; GO:0005694|chromosome|IEA; GO:0006334|nucleosome assembly|IEA; GO:0007001|chromosome organization and biogenesis (sensu Eukaryota)|IEA

ACL00001505

ODD OZ protein related cluster

146

3e-08

31% (39/123)

GO:0005887|integral to plasma membrane|IDA; GO:0007155|cell adhesion|IMP; GO:0008360|regulation of cell shape|IMP

ACL00001507

TKT1

Transketolase 1 related cluster

272

8e-24

81% (50/61)

2.2.1.1

Carbohydrate transport and metabolism

GO:0004802|transketolase activity|IEA; GO:0004802|transketolase activity|IMP; GO:0005509|calcium ion binding|IEA; GO:0006098|pentose-phosphate shunt|IMP; GO:0016740|transferase activity|IEA

ACL00001509

unclassified

ACL00001513

Putative glycohydrolase related cluster

154

7e-10

28% (49/173)

Posttranslational modification, protein turnover, chaperones

GO:0016787|hydrolase activity|IEA

ACL00001515

Microsomal signal peptidase 23 kDa subunit related cluster

252

2e-21

40% (54/134)

GO:0005783|endoplasmic reticulum|IEA; GO:0005787|signal peptidase complex|IEA; GO:0005792|microsome|IEA; GO:0006465|signal peptide processing|IEA; GO:0008233|peptidase activity|IEA; GO:0009003|signal peptidase activity|IEA; GO:0016021|integral to membrane|IEA; GO:0016787|hydrolase activity|IEA

ACL00001516

C43BP

Goodpasture antigen-binding protein related cluster

122

6e-06

31% (54/174)

2.7.1.37

GO:0004672|protein kinase activity|IEA; GO:0004672|protein kinase activity|TAS; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0006468|protein amino acid phosphorylation|TAS; GO:0006955|immune response|NAS; GO:0008372|cellular_component unknown|ND; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00001517

GPDA

Glycerol-3-phosphate dehydrogenase [NAD(P)+] related cluster

371

9e-35

38% (81/212)

1.1.1.94

Energy production and conversion

GO:0004367|glycerol-3-phosphate dehydrogenase (NAD+) activity|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0006072|glycerol-3-phosphate metabolism|IEA; GO:0008654|phospholipid biosynthesis|IEA; GO:0009331|glycerol-3-phosphate dehydrogenase complex|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016614|oxidoreductase activity, acting on CH-OH group of donors|IEA; GO:0016616|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|IEA; GO:0046167|glycerol-3-phosphate biosynthesis|IEA; GO:0047952|glycerol-3-phosphate dehydrogenase [NAD(P)+] activity|IEA

ACL00001520

multi-domain protein

120

6e-07

27% (22/80)

ACL00001521

unclassified

ACL00001522

unclassified

ACL00001523

unclassified

ACL00001524

unclassified

ACL00001525

Ssr1

Translocon-associated protein, alpha subunit precursor related cluster

110

5e-18

28% (25/89)

GO:0005048|signal sequence binding|TAS; GO:0005509|calcium ion binding|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0005783|endoplasmic reticulum|TAS; GO:0006613|cotranslational protein-membrane targeting|TAS; GO:0008284|positive regulation of cell proliferation|TAS; GO:0016021|integral to membrane|IEA; GO:0016021|integral to membrane|TAS

ACL00001526

unclassified

ACL00001527

unclassified

ACL00001528

unclassified

ACL00001529

unclassified

ACL00001530

unclassified

ACL00001532

unclassified

ACL00001533

unclassified

ACL00001534

unclassified

ACL00001535

unclassified

ACL00001536

unclassified

ACL00001537

Pin

Dynein light chain related cluster

244

1e-20

66% (41/62)

GO:0003774|motor activity|IEA; GO:0003777|microtubule motor activity|IEA; GO:0005875|microtubule associated complex|IEA; GO:0007017|microtubule-based process|IEA; GO:0030286|dynein complex|IEA

ACL00001538

unclassified

ACL00001539

PSA1

Proteasome subunit alpha type 1 related cluster

811

1e-85

63% (153/241)

3.4.25.1

Posttranslational modification, protein turnover, chaperones

GO:0004175|endopeptidase activity|IEA; GO:0005829|cytosol|IEA; GO:0005839|proteasome core complex (sensu Eukaryota)|IEA; GO:0006511|ubiquitin-dependent protein catabolism|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00001542

unclassified

ACL00001543

unclassified

ACL00001544

ankyrin G

192

3e-14

42% (46/107)

General function prediction only

ACL00001545

SOF1 protein-like protein related cluster

174

2e-12

46% (36/77)

ACL00001547

unclassified

ACL00001548

calmodulin [KO:K02183]

169

8e-12

32% (36/112)

Phosphatidylinositol signaling system

ACL00001549

unclassified

ACL00001550

Similar to phenylalanine-tRNA synthetase related cluster

162

5e-11

33% (33/99)

GO:0004812|tRNA ligase activity|IEA; GO:0004826|phenylalanine-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006432|phenylalanyl-tRNA aminoacylation|IEA

ACL00001551

unclassified

ACL00001552

unclassified

ACL00001553

Rpl22

Ribosomal protein L22 related cluster

257

1e-21

50% (50/99)

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00001554

Aminopeptidase related cluster

303

3e-27

42% (63/148)

Amino acid transport and metabolism

GO:0004177|aminopeptidase activity|IEA; GO:0004179|membrane alanyl aminopeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA

ACL00001555

Sod1

Superoxide dismutase related cluster

475

6e-47

61% (89/144)

1.15.1.1

Inorganic ion transport and metabolism

Amyotrophic lateral sclerosis (ALS) Neurodegenerative Disorders

GO:0004784|superoxide dismutase activity|IEA; GO:0004785|copper, zinc superoxide dismutase activity|IEA; GO:0006801|superoxide metabolism|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0046872|metal ion binding|IEA

ACL00001556

unclassified

ACL00001557

Rplp1

60S acidic ribosomal protein P1 related cluster

138

6e-08

45% (26/57)

Translation, ribosomal structure and biogenesis

GO:0003723|RNA binding|TAS; GO:0003735|structural constituent of ribosome|IEA; GO:0003735|structural constituent of ribosome|TAS; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0005842|cytosolic large ribosomal subunit (sensu Eukaryota)|TAS; GO:0006412|protein biosynthesis|IEA; GO:0006412|protein biosynthesis|TAS; GO:0006414|translational elongation|IEA

ACL00001559

unclassified

ACL00001560

unclassified

ACL00001561

unclassified

ACL00001562

unclassified

ACL00001563

Calreticulin precursor related cluster

354

6e-33

54% (67/124)

GO:0005509|calcium ion binding|IEA; GO:0005529|sugar binding|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0006457|protein folding|IEA; GO:0051082|unfolded protein binding|IEA

ACL00001564

unclassified

ACL00001565

unclassified

ACL00001566

unclassified

ACL00001567

Putative acyl carrier protein, mitochondrial precursor related cluster

221

1e-17

50% (42/83)

1.6.5.3 1.6.99.3

Oxidative phosphorylation

GO:0000036|acyl carrier activity|IEA; GO:0005739|mitochondrion|IEA; GO:0006633|fatty acid biosynthesis|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0048037|cofactor binding|IEA

ACL00001569

unclassified

ACL00001570

putative translation initiation factor protein [KO:K02519]

126

4e-06

32% (53/165)

Translation, ribosomal structure and biogenesis

ACL00001572

Unassigned protein

ACL00001573

unclassified

ACL00001574

Arginine/serine-rich splicing factor RSP41 related cluster

278

4e-24

46% (61/130)

GO:0003723|RNA binding|IEA; GO:0005634|nucleus|IEA

ACL00001575

unclassified

ACL00001576

RRNA methylase, putative related cluster

137

5e-08

51% (33/64)

2.1.1.-

Translation, ribosomal structure and biogenesis

GO:0003723|RNA binding|IEA; GO:0006396|RNA processing|IEA; GO:0008168|methyltransferase activity|IEA; GO:0008173|RNA methyltransferase activity|IEA; GO:0009451|RNA modification|IEA

ACL00001577

unclassified

ACL00001578

unclassified

ACL00001579

unclassified

ACL00001581

Putative glucanase related cluster

553

7e-56

45% (106/234)

GO:0004553|hydrolase activity, hydrolyzing O-glycosyl compounds|IEA; GO:0005975|carbohydrate metabolism|IEA

ACL00001582

unclassified

ACL00001583

RBSK

Ribokinase related cluster

360

7e-34

49% (79/160)

2.7.1.15

Carbohydrate transport and metabolism

Pentose phosphate pathway

GO:0004747|ribokinase activity|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0006014|D-ribose metabolism|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00001584

Solanesyl pyrophosphate synthase related cluster

117

8e-06

41% (23/56)

Coenzyme transport and metabolism

GO:0008299|isoprenoid biosynthesis|IEA; GO:0016740|transferase activity|IEA; GO:0050347|trans-octaprenyltranstransferase activity|IEA

ACL00001585

unclassified

ACL00001586

U6 snRNA-associated Sm-like protein LSm5 related cluster

262

1e-22

68% (50/73)

Transcription

GO:0000398|nuclear mRNA splicing, via spliceosome|IEA; GO:0003723|RNA binding|IEA; GO:0003723|RNA binding|TAS; GO:0005634|nucleus|IEA; GO:0005634|nucleus|TAS; GO:0005732|small nucleolar ribonucleoprotein complex|IEA; GO:0006397|mRNA processing|IEA; GO:0006397|mRNA processing|TAS; GO:0008248|pre-mRNA splicing factor activity|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00001587

unclassified

ACL00001589

unclassified

ACL00001590

Thioredoxin related cluster

248

1e-20

52% (49/94)

GO:0005489|electron transporter activity|IEA; GO:0006118|electron transport|IEA

ACL00001592

Unassigned protein

ACL00001593

unclassified

ACL00001595

unclassified

ACL00001596

Protein translation factor SUI1 homolog related cluster

114

6e-19

47% (26/55)

Translation, ribosomal structure and biogenesis

GO:0003743|translation initiation factor activity|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006413|translational initiation|IEA; GO:0006417|regulation of protein biosynthesis|IEA; GO:0006445|regulation of translation|IEA

ACL00001597

unclassified

ACL00001599

unclassified

ACL00001600

Putative glutamine synthetase related cluster

151

9e-10

48% (31/64)

Nucleotide transport and metabolism

GO:0003824|catalytic activity|IEA

ACL00001601

Fbxw7

F-box/WD-repeat protein 7 related cluster

274

1e-23

37% (55/145)

Neurodegenerative Disorders

GO:0003700|transcription factor activity|IDA; GO:0005515|protein binding|IPI; GO:0005634|nucleus|IDA; GO:0005634|nucleus|IEA; GO:0005737|cytoplasm|TAS; GO:0005783|endoplasmic reticulum|IDA; GO:0005794|Golgi apparatus|IDA; GO:0006512|ubiquitin cycle|IEA; GO:0007219|Notch signaling pathway|IDA

ACL00001602

Rac1

Rac related cluster

641

5e-66

64% (125/195)

Cadherin-mediated cell adhesion MAPK signaling pathway Regulation of actin cytoskeleton Toll-like receptor signaling pathway Wnt signaling pathway

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00001603

multi-domain protein

115

2e-06

27% (29/105)

ACL00001604

PUTATIVE CYTOSOLIC NADP-MALIC ENZYME

342

4e-32

51% (64/125)

Energy production and conversion

ACL00001605

unclassified

ACL00001606

unclassified

ACL00001607

Generic methyltransferase related cluster

142

1e-08

42% (27/64)

GO:0005554|molecular_function unknown|IEA; GO:0008168|methyltransferase activity|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00001608

unclassified

ACL00001609

Herpes_gp2 domain containing protein

118

7e-07

26% (43/162)

ACL00001611

T20F21.13; dual specificity protein phosphatase family protein

231

9e-19

40% (56/140)

Signal transduction mechanisms

ACL00001612

Putative ribosomal RNA methyltransferase 1 related cluster

252

3e-48

85% (46/54)

GO:0006364|rRNA processing|IEA; GO:0008168|methyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00001613

unclassified

ACL00001614

unclassified

ACL00001615

DCOR2

Ornithine decarboxylase 2 related cluster

304

1e-84

45% (59/131)

4.1.1.17

Amino acid transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0004586|ornithine decarboxylase activity|IEA; GO:0006596|polyamine biosynthesis|IEA; GO:0016829|lyase activity|IEA; GO:0016831|carboxy-lyase activity|IEA

ACL00001616

unclassified

ACL00001619

HEXA

Beta-hexosaminidase A precursor related cluster

175

2e-36

40% (37/91)

3.2.1.52

Carbohydrate transport and metabolism

GO:0004563|beta-N-acetylhexosaminidase activity|IEA; GO:0005764|lysosome|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0016787|hydrolase activity|IEA; GO:0016798|hydrolase activity, acting on glycosyl bonds|IEA

ACL00001620

Unknown EST

64

8e-07

50% (9/18)

ACL00001621

unclassified

ACL00001623

unclassified

ACL00001625

unclassified

ACL00001626

60S ribosomal protein L4-1 related cluster

452

4e-44

54% (95/175)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00001628

unclassified

ACL00001629

NFS1

Probable cysteine desulfurase, mitochondrial precursor related cluster

363

2e-34

67% (74/109)

2.8.1.7

Amino acid transport and metabolism

GO:0005739|mitochondrion|IEA; GO:0008152|metabolism|IEA; GO:0008483|transaminase activity|IEA; GO:0016740|transferase activity|IEA; GO:0031071|cysteine desulfurase activity|IEA

ACL00001630

Unknown EST

258

2e-25

61% (53/86)

ACL00001631

unclassified

ACL00001633

unclassified

ACL00001634

unclassified

ACL00001635

DHCA

Carbonyl reductase [NADPH] 1 related cluster

462

2e-45

49% (102/205)

1.1.1.184

Prostaglandin and leukotriene metabolism

GO:0004090|carbonyl reductase (NADPH) activity|IEA; GO:0004090|carbonyl reductase (NADPH) activity|TAS; GO:0005829|cytosol|NR; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0047021|15-hydroxyprostaglandin dehydrogenase (NADP+) activity|IEA; GO:0050221|prostaglandin-E2 9-reductase activity|IEA

ACL00001637

Probable phospho-2-dehydro-3-deoxyheptonate aldolase related cluster

718

6e-75

63% (146/229)

2.5.1.54

Phenylalanine, tyrosine and tryptophan biosynthesis

GO:0003849|3-deoxy-7-phosphoheptulonate synthase activity|IEA; GO:0009058|biosynthesis|IEA; GO:0009073|aromatic amino acid family biosynthesis|IEA; GO:0016829|lyase activity|IEA

ACL00001638

Probable homocitrate synthase, mitochondrial isozyme precursor(ec 4.1.3.21) related cluster

439

7e-43

71% (81/114)

2.3.3.14

Amino acid transport and metabolism

Lysine biosynthesis Pyruvate metabolism

GO:0003824|catalytic activity|IEA; GO:0008152|metabolism|IEA; GO:0016740|transferase activity|IEA; GO:0016829|lyase activity|IEA

ACL00001639

ABC transporter ABCA.7 related cluster

613

6e-63

58% (118/203)

Defense mechanisms

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0016887|ATPase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

ACL00001640

unclassified

ACL00001642

unclassified

ACL00001644

[J] COG0480 Translation elongation factors (GTPases)

117

2e-06

53% (24/45)

Translation, ribosomal structure and biogenesis

ACL00001645

unclassified

ACL00001646

asnS

asnS; probable asparagine-tRNA ligase [EC:6.1.1.22] [KO:K01893]

82

8e-10

63% (14/22)

6.1.1.22

Alanine and aspartate metabolism Aminoacyl-tRNA biosynthesis

ACL00001647

unclassified

ACL00001648

unclassified

ACL00001649

multi-domain protein

143

4e-11

27% (25/91)

ACL00001652

unclassified

ACL00001654

Unassigned protein

ACL00001655

Bap31 domain containing protein

132

2e-08

23% (38/162)

ACL00001656

HMDH2

3-hydroxy-3-methylglutaryl-coenzyme A reductase 2 related cluster

462

7e-46

78% (87/111)

1.1.1.34

Lipid transport and metabolism

GO:0004420|hydroxymethylglutaryl-CoA reductase (NADPH) activity|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0006629|lipid metabolism|IEA; GO:0006695|cholesterol biosynthesis|IEA; GO:0009058|biosynthesis|IEA; GO:0016021|integral to membrane|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00001657

unclassified

ACL00001658

unclassified

ACL00001659

Unknown EST

122

9e-07

35% (25/70)

ACL00001660

Homologue of Sarcophaga 26,29kDa proteinase related cluster

130

2e-07

33% (40/121)

GO:0004197|cysteine-type endopeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008233|peptidase activity|IEA; GO:0008234|cysteine-type peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00001661

Peroxisomal-coenzyme A synthetase related cluster

176

1e-12

66% (37/56)

GO:0003824|catalytic activity|IEA; GO:0005737|cytoplasm|IDA; GO:0005777|peroxisome|IEA; GO:0005778|peroxisomal membrane|IDA; GO:0005782|peroxisomal matrix|IDA; GO:0008152|metabolism|IEA; GO:0016874|ligase activity|IEA

ACL00001664

unclassified

ACL00001665

Exostosin domain containing protein

138

5e-10

43% (18/41)

ACL00001666

unclassified

ACL00001667

unclassified

ACL00001668

SYT

Threonyl-tRNA synthetase, mitochondrial precursor related cluster

184

1e-13

46% (38/81)

6.1.1.3

Translation, ribosomal structure and biogenesis

Aminoacyl-tRNA biosynthesis Glycine, serine and threonine metabolism

GO:0004812|tRNA ligase activity|IEA; GO:0004829|threonine-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0005739|mitochondrion|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006418|tRNA aminoacylation for protein translation|IEA; GO:0006435|threonyl-tRNA aminoacylation|IEA; GO:0016874|ligase activity|IEA

ACL00001669

Putative protein with similarity to putative prostate cancer tumor suppressor related cluster

135

3e-07

21% (69/314)

ACL00001671

RPB7

DNA-directed RNA polymerase II 19 kDa polypeptide related cluster

577

1e-58

61% (108/176)

2.7.7.6

Transcription

Purine metabolism Pyrimidine metabolism RNA polymerase

GO:0003723|RNA binding|IEA; GO:0003899|DNA-directed RNA polymerase activity|IEA; GO:0005634|nucleus|IEA; GO:0006350|transcription|IEA; GO:0016740|transferase activity|IEA

ACL00001672

putative protein, with at least 8 transmembrane domains, a coiled coil-4 domain, of bilaterial origin (73.6 kD) (2L582) [Caenorhabditis elegans] pir||T20034 hypothetical protein C47G2.4 - Caenorhabditis elegans emb|CAA88936.1| Hypothetical protein C47G2.4 [Caenorhabditis elegans]

222

2e-17

32% (41/125)

ACL00001673

HSPC031 related cluster

513

2e-51

57% (101/176)

GO:0003723|RNA binding|IEA; GO:0005634|nucleus|IEA; GO:0007046|ribosome biogenesis|IEA

ACL00001675

[C] COG0277 FAD/FMN-containing dehydrogenases

138

7e-09

32% (38/118)

Energy production and conversion

ACL00001676

PEPM

Phosphoenolpyruvate phosphomutase related cluster

1059

1e-114

73% (206/281)

5.4.2.9

Aminophosphonate metabolism

GO:0000287|magnesium ion binding|IEA; GO:0003824|catalytic activity|IEA; GO:0008152|metabolism|IEA; GO:0016853|isomerase activity|IEA; GO:0050188|phosphoenolpyruvate mutase activity|IEA

ACL00001677

Unknown EST

121

3e-10

100% (23/23)

ACL00001678

Unknown EST

112

6e-06

45% (21/46)

ACL00001679

unclassified

ACL00001680

FAS1 domain containing protein

117

3e-08

28% (28/98)

ACL00001682

CG10117

TTV protein related cluster

126

1e-06

32% (32/98)

GO:0007224|smoothened signaling pathway|NAS; GO:0008151||IEA; GO:0015012|heparan sulfate proteoglycan biosynthesis|TAS; GO:0015014|heparan sulfate proteoglycan biosynthesis, polysaccharide chain biosynthesis|IMP; GO:0016020|membrane|IEA

ACL00001683

NIF3L1

NIF3-like protein 1 related cluster

159

1e-10

49% (31/63)

ACL00001684

Similar to Petunia hybrida (Petunia). proteasome subunit beta type 1 related cluster

601

2e-61

55% (120/218)

Posttranslational modification, protein turnover, chaperones

GO:0004175|endopeptidase activity|IEA; GO:0005829|cytosol|IEA; GO:0005839|proteasome core complex (sensu Eukaryota)|IEA; GO:0006511|ubiquitin-dependent protein catabolism|IEA

ACL00001685

GGT

Gamma-glutamyltranspeptidase precursor related cluster

134

8e-08

37% (28/75)

2.3.2.2

Amino acid transport and metabolism

Cyanoamino acid metabolism Glutathione metabolism Selenoamino acid metabolism Taurine and hypotaurine metabolism

GO:0003840|gamma-glutamyltransferase activity|IEA; GO:0006750|glutathione biosynthesis|IEA; GO:0008415|acyltransferase activity|IEA; GO:0016740|transferase activity|IEA; GO:0042597|periplasmic space|IEA

ACL00001686

WD-40 repeat protein

140

4e-08

26% (42/161)

General function prediction only

ACL00001687

Probable aldolase related cluster

54

1e-91

39% (11/28)

2.5.1.54

Phenylalanine, tyrosine and tryptophan biosynthesis

GO:0003849|3-deoxy-7-phosphoheptulonate synthase activity|IEA; GO:0009073|aromatic amino acid family biosynthesis|IEA

ACL00001688

unclassified

ACL00001689

Unassigned protein

ACL00001693

unclassified

ACL00001694

unclassified

ACL00001697

Tobacco mosaic virus helicase domain-binding protein related cluster

270

1e-23

49% (62/126)

GO:0000166|nucleotide binding|IEA; GO:0004386|helicase activity|IEA; GO:0005524|ATP binding|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

ACL00001698

Mito_carr domain containing protein

104

4e-06

40% (19/47)

ACL00001699

FMO5

Dimethylaniline monooxygenase [N-oxide forming] 5 related cluster

117

8e-06

46% (23/50)

1.14.13.8

GO:0000004|biological_process unknown|ND; GO:0004497|monooxygenase activity|IEA; GO:0004499|dimethylaniline monooxygenase (N-oxide-forming) activity|IEA; GO:0004499|dimethylaniline monooxygenase (N-oxide-forming) activity|NAS; GO:0005792|microsome|IEA; GO:0005792|microsome|NAS; GO:0006118|electron transport|IEA; GO:0015036|disulfide oxidoreductase activity|IEA; GO:0016021|integral to membrane|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00001700

unclassified

ACL00001701

COP9 signalosome complex subunit 1 related cluster

1078

1e-116

54% (222/405)

GO:0005634|nucleus|IEA; GO:0007275|development|IEA; GO:0008180|signalosome complex|IEA

ACL00001702

unclassified

ACL00001703

unclassified

ACL00001704

26S protease regulatory subunit 8 related cluster

1515

1e-167

84% (298/353)

Posttranslational modification, protein turnover, chaperones

GO:0000502|proteasome complex (sensu Eukaryota)|TAS; GO:0003712|transcription cofactor activity|TAS; GO:0006366|transcription from Pol II promoter|TAS; GO:0016887|ATPase activity|TAS

ACL00001705

unclassified

ACL00001706

P4Hc domain containing protein

173

1e-14

21% (30/138)

ACL00001707

EIF2B2

Translation initiation factor eIF-2B beta subunit related cluster

203

8e-16

52% (32/61)

Translation, ribosomal structure and biogenesis

GO:0003743|translation initiation factor activity|IEA; GO:0005525|GTP binding|IEA; GO:0005851|eukaryotic translation initiation factor 2B complex|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006413|translational initiation|IEA

ACL00001708

UNC93A

UNC93A protein precursor related cluster

228

5e-18

34% (46/135)

ACL00001709

LOC286426

Porin related cluster

122

2e-06

28% (38/133)

GO:0005741|mitochondrial outer membrane|IEA; GO:0006820|anion transport|IEA; GO:0008308|voltage-gated ion-selective channel activity|IEA; GO:0015288|porin activity|IEA; GO:0016021|integral to membrane|IEA; GO:0019867|outer membrane|IEA

ACL00001710

PRPK

p53-related protein kinase related cluster

196

1e-38

50% (40/80)

2.7.1.37

Signal transduction mechanisms

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005515|protein binding|IPI; GO:0005524|ATP binding|IEA; GO:0005634|nucleus|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016740|transferase activity|IEA

ACL00001711

Similar to COP9 homolog related cluster

319

7e-29

38% (60/157)

GO:0005634|nucleus|IEA; GO:0008180|signalosome complex|IEA

ACL00001712

unclassified

ACL00001713

Mvp

Major vault protein related cluster

224

3e-18

63% (42/66)

GO:0005634|nucleus|IEA; GO:0005634|nucleus|TAS; GO:0005737|cytoplasm|TAS; GO:0030529|ribonucleoprotein complex|IEA; GO:0042493|response to drug|TAS

ACL00001714

unclassified

ACL00001715

LOC381811

Calmodulin related cluster

172

3e-12

48% (28/58)

GO:0005921|gap junction|TAS

ACL00001716

multi-domain protein

128

2e-08

43% (28/64)

ACL00001717

TOB protein related cluster

147

1e-08

32% (37/115)

ACL00001718

Probable hydrolase related cluster

240

1e-19

31% (61/192)

General function prediction only

GO:0003824|catalytic activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00001719

unclassified

ACL00001722

unclassified

ACL00001723

FAAA

Fumarylacetoacetase related cluster

441

3e-43

59% (78/131)

3.7.1.2

Styrene degradation Tyrosine metabolism

GO:0003824|catalytic activity|IEA; GO:0004334|fumarylacetoacetase activity|IEA; GO:0004334|fumarylacetoacetase activity|TAS; GO:0006559|L-phenylalanine catabolism|IEA; GO:0006572|tyrosine catabolism|IEA; GO:0006572|tyrosine catabolism|TAS; GO:0008152|metabolism|IEA; GO:0009072|aromatic amino acid family metabolism|IEA; GO:0016787|hydrolase activity|IEA

ACL00001724

unclassified

ACL00001726

Eif4el3

Eukaryotic translation initiation factor 4E type 3 related cluster

535

7e-54

65% (93/141)

Translation, ribosomal structure and biogenesis

GO:0000339|RNA cap binding|TAS; GO:0003723|RNA binding|IEA; GO:0003743|translation initiation factor activity|IEA; GO:0005737|cytoplasm|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006413|translational initiation|IEA; GO:0006417|regulation of protein biosynthesis|IEA; GO:0006445|regulation of translation|IEA; GO:0006445|regulation of translation|TAS; GO:0008135|translation factor activity, nucleic acid binding|TAS

ACL00001728

multi-domain protein

112

2e-06

32% (26/79)

ACL00001729

unclassified

ACL00001730

OST3_OST6 domain containing protein

137

2e-09

32% (22/67)

ACL00001733

unclassified

ACL00001734

3-hydroxybutyryl-CoA dehydratase related cluster

147

9e-09

25% (54/214)

4.2.1.17

Lipid transport and metabolism

Butanoate metabolism

GO:0003824|catalytic activity|IEA; GO:0003859|3-hydroxybutyryl-CoA dehydratase activity|IEA; GO:0008152|metabolism|IEA; GO:0016829|lyase activity|IEA

ACL00001736

unclassified

ACL00001737

unclassified

ACL00001738

unclassified

ACL00001740

unclassified

ACL00001741

Probable N-hydroxyarylamine O-acetyltransferase related cluster

117

8e-06

40% (24/60)

Secondary metabolites biosynthesis, transport and catabolism

GO:0004060|arylamine N-acetyltransferase activity|IEA; GO:0008152|metabolism|IEA; GO:0008415|acyltransferase activity|IEA; GO:0016407|acetyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00001742

YPK1

Kinase Akt/PKB related cluster

332

9e-31

47% (59/124)

2.7.1.37

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00001743

RTPR

Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase related cluster

134

8e-08

39% (34/86)

1.17.4.2

GO:0003824|catalytic activity|IEA; GO:0006260|DNA replication|IEA; GO:0008998|ribonucleoside-triphosphate reductase activity|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00001744

multi-domain protein

146

8e-10

22% (62/271)

ACL00001745

Putative CMF receptor CMFR1 related cluster

672

2e-69

44% (153/341)

GO:0004497|monooxygenase activity|IEA; GO:0004872|receptor activity|IEA; GO:0006118|electron transport|IEA; GO:0006725|aromatic compound metabolism|IEA; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00001746

Transport protein particle component Bet3p-like protein related cluster

242

2e-20

58% (50/85)

ACL00001747

unclassified

ACL00001748

Unknown EST

135

5e-09

39% (27/69)

ACL00001750

unclassified

ACL00001751

unclassified

ACL00001752

unclassified

ACL00001753

Two-component hybrid sensor and regulator related cluster

159

3e-10

35% (33/93)

2.7.3.-

GO:0000155|two-component sensor molecule activity|IEA; GO:0000156|two-component response regulator activity|IEA; GO:0000160|two-component signal transduction system (phosphorelay)|IEA; GO:0003677|DNA binding|IEA; GO:0004871|signal transducer activity|IEA; GO:0005524|ATP binding|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0007165|signal transduction|IEA; GO:0007600|sensory perception|IEA; GO:0008020|G-protein coupled photoreceptor activity|IEA; GO:0016020|membrane|IEA; GO:0016301|kinase activity|IEA; GO:0016310|phosphorylation|IEA; GO:0016740|transferase activity|IEA; GO:0016772|transferase activity, transferring phosphorus-containing groups|IEA

ACL00001755

unclassified

ACL00001756

unclassified

ACL00001758

VATA2

Vacuolar ATP synthase catalytic subunit A, osteoclast isoform related cluster

727

3e-76

75% (137/181)

3.6.3.14

Energy production and conversion

GO:0005524|ATP binding|IEA; GO:0005886|plasma membrane|TAS; GO:0006754|ATP biosynthesis|IEA; GO:0015078|hydrogen ion transporter activity|IEA; GO:0015986|ATP synthesis coupled proton transport|IEA; GO:0015992|proton transport|IEA; GO:0015992|proton transport|TAS; GO:0016469|proton-transporting two-sector ATPase complex|IEA; GO:0016469|proton-transporting two-sector ATPase complex|TAS; GO:0016787|hydrolase activity|IEA; GO:0046933|hydrogen-transporting ATP synthase activity, rotational mechanism|IEA; GO:0046961|hydrogen-transporting ATPase activity, rotational mechanism|IEA

ACL00001759

SYC

Cysteinyl-tRNA synthetase related cluster

336

4e-31

45% (67/148)

6.1.1.16

Translation, ribosomal structure and biogenesis

GO:0004812|tRNA ligase activity|IEA; GO:0004817|cysteine-tRNA ligase activity|IDA; GO:0004817|cysteine-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0005737|cytoplasm|IDA; GO:0006412|protein biosynthesis|IEA; GO:0006423|cysteinyl-tRNA aminoacylation|IDA; GO:0006423|cysteinyl-tRNA aminoacylation|IEA; GO:0006534|cysteine metabolism|NAS; GO:0016874|ligase activity|IEA

ACL00001760

Unassigned protein

ACL00001761

Coronin related cluster

836

1e-88

53% (155/289)

GO:0003779|actin binding|IEA

ACL00001763

prosaposin [Bos taurus] dbj|BAA95677.1| prosaposin [Bos taurus]

126

2e-06

45% (27/60)

ACL00001764

unclassified

ACL00001765

unclassified

ACL00001766

unclassified

ACL00001767

F26H11.9; XAP5 family protein

255

6e-22

73% (44/60)

ACL00001768

unclassified

ACL00001769

Sod_Fe_C domain containing protein

109

5e-07

54% (13/24)

ACL00001770

unclassified

ACL00001771

unclassified

ACL00001772

unclassified

ACL00001774

unclassified

ACL00001775

TALDO

Transaldolase related cluster

279

1e-91

63% (53/84)

2.2.1.2

Carbohydrate transport and metabolism

Pentose phosphate pathway

GO:0004801|transaldolase activity|IEA; GO:0004801|transaldolase activity|TAS; GO:0005737|cytoplasm|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0005975|carbohydrate metabolism|TAS; GO:0006098|pentose-phosphate shunt|IEA; GO:0016740|transferase activity|IEA

ACL00001776

SapB domain containing protein

113

5e-08

26% (14/53)

ACL00001777

NAP domain containing protein

188

6e-15

48% (40/83)

ACL00001780

PMA1

Probable plasma membrane ATPase related cluster

326

3e-29

38% (68/175)

3.6.3.6

Inorganic ion transport and metabolism

GO:0000287|magnesium ion binding|IEA; GO:0003824|catalytic activity|IEA; GO:0005524|ATP binding|IEA; GO:0006812|cation transport|IEA; GO:0008152|metabolism|IEA; GO:0008553|hydrogen-exporting ATPase activity, phosphorylative mechanism|IEA; GO:0015078|hydrogen ion transporter activity|IEA; GO:0015662|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|IEA; GO:0015992|proton transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016787|hydrolase activity|IEA; GO:0016820|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|IEA; GO:0016887|ATPase activity|IEA

ACL00001781

CG9375

Ras-like protein 1 related cluster

127

5e-07

36% (34/93)

GO:0000082|G1/S transition of mitotic cell cycle|TAS; GO:0001558|regulation of cell growth|TAS; GO:0001708|cell fate specification|TAS; GO:0005525|GTP binding|IEA; GO:0005525|GTP binding|NAS; GO:0006916|anti-apoptosis|NAS; GO:0007048|oncogenesis|IGI; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0007298|border cell migration (sensu Insecta)|TAS; GO:0007391|dorsal closure|TAS; GO:0007428|primary tracheal branching (sensu Insecta)|TAS; GO:0007456|eye morphogenesis (sensu Endopterygota)|IMP; GO:0007472|wing disc metamorphosis|IMP; GO:0007476|wing morphogenesis|IMP; GO:0008293|torso signaling pathway|TAS; GO:0008372|cellular_component unknown|ND; GO:0008595|determination of anterior/posterior axis, embryo|TAS; GO:0016049|cell growth|TAS; GO:0030307|positive regulation of cell growth|TAS; GO:0030381|eggshell pattern formation (sensu Insecta)|IMP; GO:0030707|ovarian follicle cell development (sensu Insecta)|TAS; GO:0040008|regulation of growth|TAS; GO:0045500|sevenless signaling pathway|TAS; GO:0046673|negative regulation of retinal programmed cell death (sensu Endopterygota)|TAS

ACL00001782

unclassified

ACL00001783

Unassigned protein

65

1e-07

23% (27/114)

ACL00001784

GLGB

1,4-alpha-glucan branching enzyme related cluster

682

1e-70

56% (132/232)

2.4.1.18

Carbohydrate transport and metabolism

Starch and sucrose metabolism

GO:0003844|1,4-alpha-glucan branching enzyme activity|IEA; GO:0003844|1,4-alpha-glucan branching enzyme activity|TAS; GO:0004553|hydrolase activity, hydrolyzing O-glycosyl compounds|IEA; GO:0004556|alpha-amylase activity|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0005977|glycogen metabolism|IEA; GO:0005977|glycogen metabolism|TAS; GO:0005978|glycogen biosynthesis|IEA; GO:0006091|generation of precursor metabolites and energy|TAS; GO:0016740|transferase activity|IEA; GO:0016757|transferase activity, transferring glycosyl groups|IEA

ACL00001785

unclassified

ACL00001786

XAP-5 protein emb|CAB46282.1| XAP-5 protein [Mus musculus]

205

2e-15

32% (61/188)

ACL00001787

eIF-2beta

Eukaryotic translation initiation factor 2 beta subunit related cluster

363

8e-34

42% (75/176)

Translation, ribosomal structure and biogenesis

GO:0003743|translation initiation factor activity|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006413|translational initiation|IEA

ACL00001788

Cell division cycle protein 48 related cluster

192

2e-14

42% (37/87)

GO:0000166|nucleotide binding|IEA; GO:0000910|cytokinesis|IEA; GO:0005524|ATP binding|IEA; GO:0008151||IEA; GO:0016787|hydrolase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

ACL00001789

unclassified

ACL00001790

Unassigned protein

136

6e-08

31% (40/129)

ACL00001791

unclassified

ACL00001792

multi-domain protein

146

8e-10

21% (71/333)

ACL00001793

unclassified

ACL00001794

unclassified

ACL00001796

LOC151194

Hepatocellular carcinoma-associated antigen HCA557b related cluster

195

8e-15

43% (48/110)

ACL00001797

unclassified

ACL00001798

Cinnamyl alcohol dehydrogenase, putative related cluster

133

1e-07

64% (25/39)

ACL00001799

unclassified

ACL00001801

Unknown EST

104

2e-18

100% (20/20)

ACL00001802

S-adenosylmethionine:diacylglycerol 3-amino-3-carboxypropyl transferase related cluster

183

7e-13

28% (51/179)

Lipid transport and metabolism

GO:0016740|transferase activity|IEA

ACL00001803

unclassified

ACL00001804

UB2D1

Ubiquitin-conjugating enzyme E2-17 kDa 1 related cluster

445

7e-44

86% (77/89)

6.3.2.19

Posttranslational modification, protein turnover, chaperones

GO:0004840|ubiquitin conjugating enzyme activity|IEA; GO:0004840|ubiquitin conjugating enzyme activity|TAS; GO:0004842|ubiquitin-protein ligase activity|IEA; GO:0004842|ubiquitin-protein ligase activity|NR; GO:0006464|protein modification|IEA; GO:0006511|ubiquitin-dependent protein catabolism|TAS; GO:0006512|ubiquitin cycle|IEA; GO:0016874|ligase activity|IEA

ACL00001805

unclassified

ACL00001806

unclassified

ACL00001807

cpvl

Carboxypeptidase related cluster

196

5e-15

51% (34/66)

Amino acid transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0004180|carboxypeptidase activity|IEA; GO:0004185|serine carboxypeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA

ACL00001808

Unassigned protein

ACL00001809

Cyclic-AMP-dependent transcription factor ATF-6 beta related cluster

138

1e-07

35% (28/80)

GO:0000794|condensed nuclear chromosome|ISS; GO:0003677|DNA binding|IEA; GO:0005515|protein binding|ISS; GO:0005634|nucleus|IEA; GO:0005769|early endosome|ISS; GO:0005783|endoplasmic reticulum|IEA; GO:0005815|microtubule organizing center|ISS; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006986|response to unfolded protein|IEA; GO:0007076|mitotic chromosome condensation|ISS; GO:0012505|endomembrane system|ISS; GO:0016021|integral to membrane|IEA; GO:0016363|nuclear matrix|ISS; GO:0016458|gene silencing|ISS; GO:0045014|negative regulation of transcription by glucose|ISS; GO:0045749|negative regulation of S phase of mitotic cell cycle|ISS; GO:0045892|negative regulation of transcription, DNA-dependent|ISS

ACL00001811

unclassified

ACL00001812

unclassified

ACL00001814

Unassigned protein

123

4e-06

34% (30/88)

ACL00001815

Probable sensor/response regulator hybrid related cluster

238

7e-20

48% (57/118)

GO:0000155|two-component sensor molecule activity|IEA; GO:0000156|two-component response regulator activity|IEA; GO:0000160|two-component signal transduction system (phosphorelay)|IEA; GO:0003677|DNA binding|IEA; GO:0005524|ATP binding|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0007165|signal transduction|IEA; GO:0007600|sensory perception|IEA; GO:0016020|membrane|IEA; GO:0016301|kinase activity|IEA; GO:0016310|phosphorylation|IEA; GO:0016740|transferase activity|IEA; GO:0016772|transferase activity, transferring phosphorus-containing groups|IEA

ACL00001817

unclassified

ACL00001818

Eukaryotic translation initiation factor 6 related cluster

437

1e-91

73% (84/114)

Translation, ribosomal structure and biogenesis

GO:0003743|translation initiation factor activity|IEA; GO:0005634|nucleus|IEA; GO:0005634|nucleus|TAS; GO:0006412|protein biosynthesis|IEA; GO:0006413|translational initiation|IEA

ACL00001819

VATA2

Vacuolar ATP synthase catalytic subunit A, osteoclast isoform related cluster

972

1e-104

72% (181/249)

3.6.3.14

Energy production and conversion

GO:0005524|ATP binding|IEA; GO:0005886|plasma membrane|TAS; GO:0006754|ATP biosynthesis|IEA; GO:0015078|hydrogen ion transporter activity|IEA; GO:0015986|ATP synthesis coupled proton transport|IEA; GO:0015992|proton transport|IEA; GO:0015992|proton transport|TAS; GO:0016469|proton-transporting two-sector ATPase complex|IEA; GO:0016469|proton-transporting two-sector ATPase complex|TAS; GO:0016787|hydrolase activity|IEA; GO:0046933|hydrogen-transporting ATP synthase activity, rotational mechanism|IEA; GO:0046961|hydrogen-transporting ATPase activity, rotational mechanism|IEA

ACL00001820

unclassified

ACL00001821

Cytochrome b5 reductase related cluster

705

4e-73

53% (129/242)

GO:0006118|electron transport|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00001823

Isy1 domain containing protein

488

1e-49

42% (92/218)

ACL00001824

60S acidic ribosomal protein PO related cluster

422

1e-40

49% (82/166)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005634|nucleus|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0007046|ribosome biogenesis|IEA

ACL00001825

Fructose-bisphosphate aldolase related cluster

250

5e-21

55% (61/109)

4.1.2.13

Carbon fixation Fructose and mannose metabolism Glycolysis / Gluconeogenesis Pentose phosphate pathway

GO:0004332|fructose-bisphosphate aldolase activity|IEA; GO:0006096|glycolysis|IEA; GO:0016829|lyase activity|IEA

ACL00001827

unclassified

ACL00001828

Ap2a2

Adapter-related protein complex 2 alpha 2 subunit related cluster

440

4e-43

52% (82/157)

GO:0005198|structural molecule activity|IEA; GO:0005554|molecular_function unknown|ND; GO:0005794|Golgi apparatus|IEA; GO:0005905|coated pit|IEA; GO:0006461|protein complex assembly|IEA; GO:0006810|transport|IEA; GO:0006886|intracellular protein transport|IEA; GO:0006886|intracellular protein transport|NAS; GO:0006897|endocytosis|IEA; GO:0008289|lipid binding|IEA; GO:0015031|protein transport|IEA; GO:0030122|AP-2 adaptor complex|NAS; GO:0030130|clathrin coat of trans-Golgi network vesicle|IEA

ACL00001831

ITPK1

Inositol 1,3,4-trisphosphate 5/6-kinase related cluster

188

8e-14

29% (51/173)

GO:0003824|catalytic activity|TAS; GO:0007165|signal transduction|TAS; GO:0016301|kinase activity|IEA

ACL00001833

Universal stress protein family related cluster

164

1e-10

26% (40/152)

Signal transduction mechanisms

GO:0006950|response to stress|IEA

ACL00001836

Putative serine protease F56F10.1 precursor related cluster

176

3e-12

40% (41/102)

GO:0003824|catalytic activity|IEA; GO:0004252|serine-type endopeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008236|serine-type peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00001838

unclassified

ACL00001839

RHOD domain containing protein

129

2e-09

26% (28/107)

ACL00001840

unclassified

ACL00001842

Unassigned protein

ACL00001843

Unassigned protein

ACL00001844

unclassified

ACL00001845

PGMU

Phosphoglucomutase, cytoplasmic related cluster

65

2e-84

56% (13/23)

5.4.2.2

Carbohydrate transport and metabolism

Galactose metabolism Glycolysis / Gluconeogenesis Pentose phosphate pathway Starch and sucrose metabolism Streptomycin biosynthesis

GO:0000287|magnesium ion binding|IEA; GO:0004614|phosphoglucomutase activity|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0016853|isomerase activity|IEA; GO:0016868|intramolecular transferase activity, phosphotransferases|IEA

ACL00001847

unclassified

ACL00001848

unclassified

ACL00001849

unclassified

ACL00001850

unclassified

ACL00001851

unclassified

ACL00001852

multi-domain protein

135

1e-08

23% (54/229)

ACL00001853

[O] COG0330 Membrane protease subunits, stomatin/prohibitin homologs

717

3e-75

56% (137/243)

Posttranslational modification, protein turnover, chaperones

ACL00001854

unclassified

ACL00001855

multi-domain protein

118

4e-07

28% (29/100)

ACL00001858

DnaJ protein homolog ATJ2 related cluster

381

4e-36

50% (78/155)

Posttranslational modification, protein turnover, chaperones

GO:0006457|protein folding|IEA; GO:0051082|unfolded protein binding|IEA

ACL00001860

unclassified

ACL00001863

unclassified

ACL00001864

unclassified

ACL00001867

unclassified

ACL00001868

unclassified

ACL00001869

unclassified

ACL00001871

unclassified

ACL00001872

unclassified

ACL00001873

unclassified

ACL00001874

unclassified

ACL00001875

unclassified

ACL00001876

unclassified

ACL00001878

unclassified

ACL00001881

unclassified

ACL00001882

unclassified

ACL00001884

Unassigned protein

120

3e-06

66% (24/36)

ACL00001885

unclassified

ACL00001887

CGL

Cystathionine gamma-lyase related cluster

983

1e-105

61% (184/297)

4.4.1.1

Amino acid transport and metabolism

GO:0004123|cystathionine gamma-lyase activity|IDA; GO:0004123|cystathionine gamma-lyase activity|IEA; GO:0006520|amino acid metabolism|IEA; GO:0016829|lyase activity|IEA; GO:0019344|cysteine biosynthesis|IEA

ACL00001888

unclassified

ACL00001889

unclassified

ACL00001890

unclassified

ACL00001891

zgc:66026

N-acylsphingosine amidohydrolase related cluster

121

3e-06

50% (27/54)

GO:0016787|hydrolase activity|IEA

ACL00001893

unclassified

ACL00001894

Csrp3

Cysteine-rich-protein related cluster

167

1e-11

43% (27/62)

GO:0008270|zinc ion binding|IEA

ACL00001895

unclassified

ACL00001896

unclassified

ACL00001897

unclassified

ACL00001898

unclassified

ACL00001899

Unassigned protein

130

2e-07

35% (26/73)

ACL00001900

PUR8

Adenylosuccinate lyase related cluster

133

1e-07

50% (22/44)

4.3.2.2

Nucleotide transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0004018|adenylosuccinate lyase activity|IEA; GO:0006164|purine nucleotide biosynthesis|IEA; GO:0009152|purine ribonucleotide biosynthesis|IEA; GO:0016829|lyase activity|IEA

ACL00001901

unclassified

ACL00001902

Cnn3

Calponin, acidic isoform related cluster

259

5e-22

43% (52/119)

Cytoskeleton

GO:0003779|actin binding|IEA; GO:0003779|actin binding|NAS; GO:0005516|calmodulin binding|IEA; GO:0005516|calmodulin binding|NAS; GO:0005523|tropomyosin binding|NAS; GO:0006939|smooth muscle contraction|IEA; GO:0006939|smooth muscle contraction|NAS; GO:0008372|cellular_component unknown|ND; GO:0030172|troponin C binding|NAS

ACL00001903

unclassified

ACL00001905

unclassified

ACL00001907

unclassified

ACL00001908

Signal recognition particle 54 kDa protein 3 related cluster

177

1e-12

34% (42/123)

Intracellular trafficking, secretion, and vesicular transport

Protein export

GO:0003723|RNA binding|IEA; GO:0005525|GTP binding|IEA; GO:0005786|signal recognition particle (sensu Eukaryota)|IEA; GO:0006605|protein targeting|IEA; GO:0006614|SRP-dependent cotranslational protein-membrane targeting|IEA

ACL00001909

Small ubiquitin-like protein related cluster

175

1e-12

57% (34/59)

Posttranslational modification, protein turnover, chaperones

ACL00001911

unclassified

ACL00001913

unclassified

ACL00001914

unclassified

ACL00001915

unclassified

ACL00001917

unclassified

ACL00001918

unclassified

ACL00001919

unclassified

ACL00001920

Dak2 domain containing protein

107

3e-06

45% (24/53)

ACL00001921

unclassified

ACL00001922

unclassified

ACL00001923

unclassified

ACL00001924

unclassified

ACL00001925

unclassified

ACL00001927

unclassified

ACL00001928

unclassified

ACL00001929

unclassified

ACL00001930

unclassified

ACL00001931

unclassified

ACL00001932

unclassified

ACL00001934

unclassified

ACL00001935

unclassified

ACL00001936

Unknown EST

103

2e-06

52% (21/40)

ACL00001937

COASY

Bifunctional coenzyme A synthase related cluster

197

4e-15

37% (45/121)

2.7.1.24

Pantothenate and CoA biosynthesis

GO:0000004|biological_process unknown|ND; GO:0000166|nucleotide binding|NAS; GO:0003824|catalytic activity|IEA; GO:0004140|dephospho-CoA kinase activity|IEA; GO:0004595|pantetheine-phosphate adenylyltransferase activity|IEA; GO:0005524|ATP binding|IEA; GO:0008372|cellular_component unknown|ND; GO:0015937|coenzyme A biosynthesis|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA; GO:0016779|nucleotidyltransferase activity|IEA

ACL00001939

unclassified

ACL00001940

GTP-binding protein Rac1p related cluster

794

7e-84

77% (145/187)

General function prediction only

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00001944

ADP-ribosylation factor 2 related cluster

452

3e-44

51% (92/180)

ACL00001945

P2X1 receptor related cluster

125

2e-06

36% (29/80)

GO:0004872|receptor activity|IEA; GO:0005216|ion channel activity|IEA; GO:0005524|ATP binding|IEA; GO:0006810|transport|IEA; GO:0006811|ion transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA

ACL00001946

unclassified

ACL00001948

Unassigned protein

207

4e-16

37% (42/112)

ACL00001949

multi-domain protein

108

1e-05

24% (27/110)

ACL00001950

unclassified

ACL00001951

Cyclic GMP-binding protein C related cluster

353

1e-32

44% (75/167)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0004713|protein-tyrosine kinase activity|IEA; GO:0005085|guanyl-nucleotide exchange factor activity|IEA; GO:0005524|ATP binding|IEA; GO:0005525|GTP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0007242|intracellular signaling cascade|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00001952

G3PC

Glyceraldehyde 3-phosphate dehydrogenase, cytosolic related cluster

366

1e-34

68% (71/104)

1.2.1.12

Carbohydrate transport and metabolism

Glycolysis / Gluconeogenesis

GO:0004365|glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity|IEA; GO:0006006|glucose metabolism|IEA; GO:0006096|glycolysis|IEA; GO:0008943|glyceraldehyde-3-phosphate dehydrogenase activity|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00001955

unclassified

ACL00001956

unclassified

ACL00001958

Unassigned protein

ACL00001959

CBS domain containing protein

99

2e-06

36% (17/47)

ACL00001960

unclassified

ACL00001961

Two-component hybrid sensor and regulator related cluster

173

6e-12

51% (35/68)

GO:0000155|two-component sensor molecule activity|IEA; GO:0000156|two-component response regulator activity|IEA; GO:0000160|two-component signal transduction system (phosphorelay)|IEA; GO:0003677|DNA binding|IEA; GO:0004871|signal transducer activity|IEA; GO:0005524|ATP binding|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0007165|signal transduction|IEA; GO:0007600|sensory perception|IEA; GO:0016020|membrane|IEA; GO:0016301|kinase activity|IEA; GO:0016310|phosphorylation|IEA; GO:0016740|transferase activity|IEA; GO:0016772|transferase activity, transferring phosphorus-containing groups|IEA

ACL00001962

Unassigned protein

ACL00001963

Small GTPase rabE related cluster

768

1e-80

75% (141/188)

General function prediction only

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00001968

Amidase related to nicotinamidase related cluster

146

3e-09

33% (38/115)

3.5.1.19

Secondary metabolites biosynthesis, transport and catabolism

Nicotinate and nicotinamide metabolism

GO:0003824|catalytic activity|IEA; GO:0008152|metabolism|IEA; GO:0008908|isochorismatase activity|IEA; GO:0009058|biosynthesis|IEA

ACL00001969

Rac1

Rac related cluster

565

4e-57

53% (104/194)

Cadherin-mediated cell adhesion MAPK signaling pathway Regulation of actin cytoskeleton Toll-like receptor signaling pathway Wnt signaling pathway

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00001970

multi-domain protein

122

3e-07

23% (44/191)

ACL00001971

Intracellular proteinase related cluster

374

2e-35

46% (72/156)

General function prediction only

GO:0016798|hydrolase activity, acting on glycosyl bonds|IEA

ACL00001972

Protein-tyrosine phosphatase-related protein related cluster

246

2e-20

33% (57/169)

Signal transduction mechanisms

GO:0004721|phosphoprotein phosphatase activity|IEA; GO:0006470|protein amino acid dephosphorylation|IEA

ACL00001974

DPM1

Dolichol phosphate mannose synthase related cluster

745

6e-78

61% (143/234)

2.4.1.83

N-Glycan biosynthesis

ACL00001975

mmsB

3-hydroxyacid dehydrogenase related cluster

404

2e-38

33% (94/284)

1.1.1.31

Lipid transport and metabolism

Valine, leucine and isoleucine degradation

ACL00001976

Histone H2A-like protein related cluster

427

3e-41

82% (84/102)

Chromatin structure and dynamics

GO:0000786|nucleosome|IEA; GO:0003677|DNA binding|IEA; GO:0005634|nucleus|IEA; GO:0005694|chromosome|IEA; GO:0006334|nucleosome assembly|IEA; GO:0007001|chromosome organization and biogenesis (sensu Eukaryota)|IEA

ACL00001977

NSR1

Nuclear localization sequence binding protein related cluster

174

2e-11

23% (51/213)

General function prediction only

GO:0000028|ribosomal small subunit assembly and maintenance|TAS; GO:0003677|DNA binding|IEA; GO:0003697|single-stranded DNA binding|IDA; GO:0003723|RNA binding|IEA; GO:0005634|nucleus|IDA; GO:0005634|nucleus|IEA; GO:0005730|nucleolus|TAS; GO:0005739|mitochondrion|IDA; GO:0006364|rRNA processing|IEA; GO:0006364|rRNA processing|TAS

ACL00001978

TP2 domain containing protein

107

8e-06

25% (27/106)

ACL00001979

Polyubiquitin related cluster

1110

1e-120

97% (222/228)

ACL00001982

CG7641

Neurocalcin homolog related cluster

180

1e-12

28% (49/170)

GO:0005509|calcium ion binding|IEA

ACL00001983

HSPC039

HSPC039 protein related cluster

73

6e-07

66% (14/21)

GO:0016021|integral to membrane|IEA

ACL00001990

unclassified

ACL00001992

LOC268449

Ribosomal protein L23a related cluster

509

9e-51

66% (98/147)

Translation, ribosomal structure and biogenesis

GO:0003723|RNA binding|IEA; GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00001994

Rpl27

60S ribosomal protein L27 related cluster

356

3e-33

51% (69/134)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00001995

unclassified

ACL00001996

TRX2

Thioredoxin related cluster

274

5e-24

54% (50/92)

GO:0005489|electron transporter activity|IEA; GO:0006118|electron transport|IEA

ACL00001997

Putative ribosomal protein L26 related cluster

420

1e-40

56% (81/143)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0015934|large ribosomal subunit|IEA

ACL00001998

Thioredoxin peroxidase BgTPx related cluster

691

7e-72

65% (128/194)

GO:0004601|peroxidase activity|IEA

ACL00001999

ATP synthase subunit, probable related cluster

160

8e-11

45% (27/59)

Energy production and conversion

GO:0015986|ATP synthesis coupled proton transport|IEA; GO:0016469|proton-transporting two-sector ATPase complex|IEA; GO:0016787|hydrolase activity|IEA; GO:0046933|hydrogen-transporting ATP synthase activity, rotational mechanism|IEA; GO:0046961|hydrogen-transporting ATPase activity, rotational mechanism|IEA

ACL00002001

Ribosomal protein L37A related cluster

328

3e-30

63% (57/90)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00002006

BolA-like family protein [Arabidopsis thaliana] dbj|BAB09404.1| unnamed protein product [Arabidopsis thaliana] gb|AAM65194.1| unknown [Arabidopsis thaliana] gb|AAO24583.1| At5g09830 [Arabidopsis thaliana]

128

1e-06

42% (25/59)

ACL00002007

DM6 domain containing protein

87

9e-05

29% (18/61)

ACL00002008

Acyl coenzyme A:monoacylglycerol acyltransferase 3 related cluster

199

4e-15

34% (52/150)

Lipid transport and metabolism

GO:0008415|acyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00002009

endopeptidase Clp ATP-binding chain B

ATP-dependent Clp protease, ATP-binding subunit ClpB related cluster

470

1e-46

61% (92/150)

Posttranslational modification, protein turnover, chaperones

GO:0000166|nucleotide binding|IEA; GO:0005515|protein binding|IEA; GO:0005524|ATP binding|IEA; GO:0006457|protein folding|IEA; GO:0006986|response to unfolded protein|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA; GO:0019538|protein metabolism|IEA; GO:0051082|unfolded protein binding|IEA

ACL00002012

multi-domain protein

134

1e-08

22% (35/155)

ACL00002019

Aminopeptidase related cluster

122

3e-06

32% (34/106)

General function prediction only

GO:0004177|aminopeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00002020

Crystallin J1C related cluster

213

9e-17

31% (54/174)

GO:0005212|structural constituent of eye lens|IEA

ACL00002021

Swollenin precursor related cluster

262

2e-22

29% (61/209)

GO:0004553|hydrolase activity, hydrolyzing O-glycosyl compounds|IEA; GO:0005576|extracellular region|IEA; GO:0005975|carbohydrate metabolism|IEA

ACL00002022

Similar to glutamate oxaloacetate transaminase 2 related cluster

855

1e-90

56% (167/293)

GO:0003824|catalytic activity|IEA; GO:0006520|amino acid metabolism|IEA; GO:0008483|transaminase activity|IEA; GO:0009058|biosynthesis|IEA; GO:0016740|transferase activity|IEA

ACL00002023

Putative methyltransferase related cluster

134

4e-07

28% (32/113)

GO:0008168|methyltransferase activity|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00002024

Fatty acid transport protein, putative related cluster

425

2e-41

54% (89/163)

GO:0003824|catalytic activity|IEA; GO:0008152|metabolism|IEA

ACL00002025

unclassified

ACL00002026

KLHDC1

Kelch domain containing protein 1 related cluster

193

2e-14

35% (54/154)

ACL00002027

unclassified

ACL00002028

unclassified

ACL00002029

Clathrin heavy chain related cluster

89

4e-44

72% (16/22)

GO:0005905|coated pit|IEA; GO:0030125|clathrin vesicle coat|IEA

ACL00002030

unclassified

ACL00002031

unclassified

ACL00002032

DUF1421 domain containing protein

111

4e-06

27% (25/90)

ACL00002033

SYW

Tryptophanyl-tRNA synthetase related cluster

456

1e-128

69% (84/121)

6.1.1.2

Translation, ribosomal structure and biogenesis

Aminoacyl-tRNA biosynthesis Tryptophan metabolism

GO:0004812|tRNA ligase activity|IEA; GO:0004830|tryptophan-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006418|tRNA aminoacylation for protein translation|IEA; GO:0006436|tryptophanyl-tRNA aminoacylation|IEA; GO:0016874|ligase activity|IEA

ACL00002034

NCPR

NADPH--cytochrome P450 reductase related cluster

365

3e-34

48% (75/154)

1.6.2.4

Inorganic ion transport and metabolism

GO:0003958|NADPH-hemoprotein reductase activity|IEA; GO:0005489|electron transporter activity|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0006118|electron transport|IEA; GO:0010181|FMN binding|IEA; GO:0016020|membrane|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00002035

MYO3

Inositol-1(or 4)-monophosphatase 3 related cluster

84

4e-15

62% (17/27)

3.1.3.25

Carbohydrate transport and metabolism

GO:0000287|magnesium ion binding|IEA; GO:0004437|inositol or phosphatidylinositol phosphatase activity|IEA; GO:0008934|inositol-1(or 4)-monophosphatase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00002037

Unassigned protein

ACL00002038

BCAT3

Branched-chain amino acid aminotransferase 3, chloroplast precursor related cluster

263

9e-23

44% (47/106)

2.6.1.42

Pantothenate and CoA biosynthesis Valine, leucine and isoleucine biosynthesis Valine, leucine and isoleucine degradation

GO:0003824|catalytic activity|IEA; GO:0004084|branched-chain-amino-acid transaminase activity|IEA; GO:0008152|metabolism|IEA; GO:0008483|transaminase activity|IEA; GO:0009081|branched chain family amino acid metabolism|IEA; GO:0009082|branched chain family amino acid biosynthesis|IEA; GO:0009507|chloroplast|IEA; GO:0016740|transferase activity|IEA

ACL00002039

unclassified

ACL00002040

Unassigned protein

130

2e-07

37% (29/78)

ACL00002041

folP

Dihydropteroate synthase related cluster

274

5e-24

48% (60/124)

2.5.1.15

Coenzyme transport and metabolism

Folate biosynthesis

GO:0004156|dihydropteroate synthase activity|IEA; GO:0009396|folic acid and derivative biosynthesis|IEA; GO:0016740|transferase activity|IEA

ACL00002042

T19J18.12; calcium-dependent protein kinase, putative / CDPK, putative

136

3e-08

32% (34/106)

ACL00002043

Prkcd

Protein kinase C, delta type related cluster

194

2e-14

36% (45/122)

Calcium signaling pathway MAPK signaling pathway Phosphatidylinositol signaling system Wnt signaling pathway

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0006917|induction of apoptosis|IDA; GO:0007242|intracellular signaling cascade|IDA; GO:0007242|intracellular signaling cascade|IEA; GO:0016020|membrane|IEA; GO:0016740|transferase activity|IEA; GO:0019992|diacylglycerol binding|IEA

ACL00002044

multi-domain protein

113

3e-06

25% (61/242)

ACL00002045

unclassified

ACL00002046

unclassified

ACL00002047

Twinkle related cluster

356

2e-33

45% (78/172)

GO:0003678|DNA helicase activity|IDA; GO:0005739|mitochondrion|IDA; GO:0006268|DNA unwinding|IDA

ACL00002048

Lipe

Hormone-sensitive lipase related cluster

171

4e-12

48% (35/72)

3.1.1.-

Lipid transport and metabolism

Alkaloid biosynthesis II Butanoate metabolism

GO:0003824|catalytic activity|IEA; GO:0004806|triacylglycerol lipase activity|IEA; GO:0008152|metabolism|IEA; GO:0016787|hydrolase activity|IEA

ACL00002049

unclassified

ACL00002050

unclassified

ACL00002051

DUF1431 domain containing protein

111

6e-06

27% (30/110)

ACL00002052

heme (2M975) [Caenorhabditis elegans]

123

4e-06

52% (24/46)

2.5.1.-

Oxidative phosphorylation

ACL00002053

unclassified

ACL00002054

unclassified

ACL00002055

Ribonuclease T2 related cluster

348

6e-32

31% (69/218)

3.1.27.1

Translation, ribosomal structure and biogenesis

GO:0003723|RNA binding|IEA; GO:0004521|endoribonuclease activity|IEA

ACL00002056

T22D6.120; ribosomal protein L7Ae family

227

9e-19

46% (47/101)

Translation, ribosomal structure and biogenesis

ACL00002057

unclassified

ACL00002058

Tnxb

Tenascin X precursor related cluster

215

7e-17

42% (43/101)

GO:0005515|protein binding|IEA; GO:0005578|extracellular matrix (sensu Metazoa)|IEA; GO:0005578|extracellular matrix (sensu Metazoa)|NAS; GO:0007155|cell adhesion|IEA; GO:0007160|cell-matrix adhesion|NAS

ACL00002059

unclassified

ACL00002060

GTP-binding protein YPTC5 related cluster

485

7e-48

51% (98/191)

General function prediction only

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00002061

unclassified

ACL00002062

STOML2

Stomatin-like protein related cluster

396

8e-38

52% (73/138)

Posttranslational modification, protein turnover, chaperones

GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA

ACL00002063

multi-domain protein

112

7e-06

24% (73/304)

ACL00002065

SYQ

Probable glutaminyl-tRNA synthetase related cluster

310

5e-28

50% (64/126)

6.1.1.18

Translation, ribosomal structure and biogenesis

Aminoacyl-tRNA biosynthesis Glutamate metabolism

GO:0004812|tRNA ligase activity|IEA; GO:0004818|glutamate-tRNA ligase activity|IEA; GO:0004819|glutamine-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006418|tRNA aminoacylation for protein translation|IEA; GO:0006424|glutamyl-tRNA aminoacylation|IEA; GO:0016874|ligase activity|IEA

ACL00002066

APH domain containing protein

166

2e-12

26% (44/164)

ACL00002067

Constitutive triple response 1-like protein kinase related cluster

286

4e-25

37% (59/158)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00002068

SYE1

Glutamyl-tRNA synthetase 1 related cluster

142

1e-08

30% (39/129)

6.1.1.17

Aminoacyl-tRNA biosynthesis Glutamate metabolism Porphyrin and chlorophyll metabolism

GO:0004812|tRNA ligase activity|IEA; GO:0004818|glutamate-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0005737|cytoplasm|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006418|tRNA aminoacylation for protein translation|IEA; GO:0006424|glutamyl-tRNA aminoacylation|IEA; GO:0016874|ligase activity|IEA

ACL00002069

unclassified

ACL00002071

Unassigned protein

174

9e-12

31% (50/157)

ACL00002072

Ras-related protein Rab-18 related cluster

322

1e-29

59% (61/102)

GO:0003924|GTPase activity|NAS; GO:0005525|GTP binding|IEA; GO:0006897|endocytosis|NAS; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0007264|small GTPase mediated signal transduction|NAS; GO:0008372|cellular_component unknown|ND; GO:0015031|protein transport|IEA

ACL00002073

unclassified

ACL00002074

unclassified

ACL00002075

Unassigned protein

ACL00002076

Unassigned protein

131

1e-07

49% (28/57)

ACL00002077

Putative cyclophilin related cluster

355

2e-33

77% (65/84)

5.2.1.8

Posttranslational modification, protein turnover, chaperones

GO:0003755|peptidyl-prolyl cis-trans isomerase activity|IEA; GO:0006457|protein folding|IEA; GO:0016853|isomerase activity|IEA

ACL00002078

HEM6

Coproporphyrinogen III oxidase, aerobic related cluster

682

1e-70

44% (140/318)

1.3.3.3

Coenzyme transport and metabolism

GO:0004109|coproporphyrinogen oxidase activity|IEA; GO:0006779|porphyrin biosynthesis|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00002079

mvp

Major vault protein alpha related cluster

508

7e-51

59% (108/181)

GO:0030529|ribonucleoprotein complex|IEA

ACL00002080

Peroxidase ppod11 related cluster

144

1e-08

39% (43/108)

GO:0004601|peroxidase activity|IEA

ACL00002081

(S)-adenosyl-L-methionine:delta 24-sterol methyltransferase related cluster

327

3e-82

58% (61/104)

2.1.1.41

GO:0008168|methyltransferase activity|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00002082

unclassified

ACL00002084

unclassified

ACL00002085

Similar to Brassica rapa subsp. pekinensis (Chinese cabbage) (Celery cabbage). Aminoalcoholphosphotransferase related cluster

251

6e-21

30% (54/179)

GO:0005198|structural molecule activity|IEA

ACL00002086

unclassified

ACL00002087

KCC1A

Calcium/calmodulin-dependent protein kinase type I related cluster

646

1e-66

57% (132/230)

2.7.1.123

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0004685|calcium- and calmodulin-dependent protein kinase activity|IEA; GO:0004685|calcium- and calmodulin-dependent protein kinase activity|TAS; GO:0005516|calmodulin binding|IEA; GO:0005524|ATP binding|IEA; GO:0005634|nucleus|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0006468|protein amino acid phosphorylation|TAS; GO:0007165|signal transduction|TAS; GO:0007399|neurogenesis|IEA; GO:0016740|transferase activity|IEA

ACL00002088

unclassified

ACL00002091

Putative nicotinate phosphoribosyltransferase related cluster

270

2e-23

65% (49/75)

Coenzyme transport and metabolism

GO:0004516|nicotinate phosphoribosyltransferase activity|IEA; GO:0016740|transferase activity|IEA; GO:0016757|transferase activity, transferring glycosyl groups|IEA; GO:0019363|pyridine nucleotide biosynthesis|IEA

ACL00002092

Trehalose-6-phosphate phosphatase related cluster

406

6e-39

39% (84/211)

Carbohydrate transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0003825|alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity|IEA; GO:0004805|trehalose-phosphatase activity|IEA; GO:0005992|trehalose biosynthesis|IEA; GO:0008152|metabolism|IEA; GO:0016787|hydrolase activity|IEA

ACL00002093

Unassigned protein

120

7e-06

34% (25/73)

ACL00002094

Tymo_45kd_70kd domain containing protein

119

6e-07

24% (49/203)

ACL00002095

DSPc domain containing protein

104

7e-07

38% (15/39)

ACL00002096

SYI

Isoleucyl-tRNA synthetase, cytoplasmic related cluster

242

8e-20

33% (58/175)

6.1.1.5

Translation, ribosomal structure and biogenesis

GO:0004812|tRNA ligase activity|IEA; GO:0004822|isoleucine-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0005625|soluble fraction|TAS; GO:0005737|cytoplasm|TAS; GO:0006412|protein biosynthesis|IEA; GO:0006412|protein biosynthesis|NR; GO:0006418|tRNA aminoacylation for protein translation|IEA; GO:0006428|isoleucyl-tRNA aminoacylation|IEA; GO:0016874|ligase activity|IEA

ACL00002097

multi-domain protein

145

1e-09

24% (88/362)

ACL00002098

INO1

Inositol-3-phosphate synthase related cluster

514

2e-51

67% (102/151)

5.5.1.4

Lipid transport and metabolism

GO:0004512|inositol-3-phosphate synthase activity|IEA; GO:0006021|myo-inositol biosynthesis|IEA; GO:0008654|phospholipid biosynthesis|IEA; GO:0016853|isomerase activity|IEA

ACL00002099

Putative 5-3 exoribonuclease related cluster

292

1e-25

43% (61/140)

GO:0003676|nucleic acid binding|IEA; GO:0004527|exonuclease activity|IEA; GO:0005634|nucleus|IEA

ACL00002100

Unknown EST

122

9e-07

53% (22/41)

ACL00002102

AKR7A3

Aflatoxin B1 aldehyde reductase member 3 related cluster

287

9e-56

45% (67/147)

1.-.-.-

Energy production and conversion

GO:0004033|aldo-keto reductase activity|TAS; GO:0005489|electron transporter activity|TAS; GO:0005829|cytosol|TAS; GO:0006081|aldehyde metabolism|TAS; GO:0016491|oxidoreductase activity|IEA

ACL00002103

Unknown EST

164

3e-13

37% (30/81)

ACL00002104

ProSAAS domain containing protein

108

7e-06

29% (33/113)

ACL00002105

IOD1

Type I iodothyronine deiodinase related cluster

183

2e-12

34% (40/115)

1.97.1.10

GO:0004800|thyroxine 5'-deiodinase activity|IEA; GO:0005615|extracellular space|TAS; GO:0016021|integral to membrane|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00002106

Probable mitochondrial import receptor subunit TOM40 homolog related cluster

180

2e-12

32% (72/223)

GO:0005739|mitochondrion|IEA; GO:0005741|mitochondrial outer membrane|IEA; GO:0006810|transport|IEA; GO:0006820|anion transport|IEA; GO:0006886|intracellular protein transport|IEA; GO:0008308|voltage-gated ion-selective channel activity|IEA; GO:0015031|protein transport|IEA; GO:0015450|protein translocase activity|IEA; GO:0016021|integral to membrane|IEA; GO:0019867|outer membrane|IEA

ACL00002107

UBP15

Ubiquitin carboxyl-terminal hydrolase 15 related cluster

153

5e-10

54% (25/46)

3.1.2.15

Posttranslational modification, protein turnover, chaperones

GO:0004197|cysteine-type endopeptidase activity|IEA; GO:0004197|cysteine-type endopeptidase activity|TAS; GO:0004221|ubiquitin thiolesterase activity|IEA; GO:0004843|ubiquitin-specific protease activity|TAS; GO:0006511|ubiquitin-dependent protein catabolism|IEA; GO:0006512|ubiquitin cycle|IEA; GO:0008234|cysteine-type peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00002108

[K] COG5033 Transcription initiation factor IIF, auxiliary subunit

122

1e-06

32% (29/88)

Transcription

ACL00002109

unclassified

ACL00002111

unclassified

ACL00002112

Unknown EST

145

8e-10

70% (29/41)

ACL00002113

Putative Nudix hydrolase lin0387 related cluster

168

1e-11

34% (42/123)

GO:0004452|isopentenyl-diphosphate delta-isomerase activity|IEA; GO:0008299|isoprenoid biosynthesis|IEA; GO:0016787|hydrolase activity|IEA

ACL00002114

unclassified

ACL00002115

CTP synthase like protein related cluster

579

4e-59

61% (113/184)

6.3.4.2

Nucleotide transport and metabolism

Pyrimidine metabolism

GO:0003824|catalytic activity|IEA; GO:0003883|CTP synthase activity|IEA; GO:0006221|pyrimidine nucleotide biosynthesis|IEA; GO:0016874|ligase activity|IEA

ACL00002116

unclassified

ACL00002117

Filamin/ABP280 repeat family member (XK45) [Caenorhabditis elegans] gb|AAN60531.1| Hypothetical protein C23F12.1a [Caenorhabditis elegans]

129

1e-06

42% (28/66)

ACL00002118

Small nuclear ribonucleoprotein homolog related cluster

335

4e-31

80% (66/82)

Transcription

GO:0005634|nucleus|IEA; GO:0005732|small nucleolar ribonucleoprotein complex|IEA; GO:0006397|mRNA processing|IEA; GO:0008248|pre-mRNA splicing factor activity|IEA; GO:0019013|viral nucleocapsid|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00002119

SYM

Probable methionyl-tRNA synthetase related cluster

226

7e-18

40% (60/150)

6.1.1.10

GO:0000049|tRNA binding|IEA; GO:0003723|RNA binding|IEA; GO:0004812|tRNA ligase activity|IEA; GO:0004825|methionine-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006418|tRNA aminoacylation for protein translation|IEA; GO:0006431|methionyl-tRNA aminoacylation|IEA; GO:0016874|ligase activity|IEA

ACL00002120

Putative carrier protein related cluster

203

2e-15

30% (57/188)

GO:0005215|transporter activity|IEA; GO:0005488|binding|IEA; GO:0005743|mitochondrial inner membrane|IEA; GO:0006810|transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA

ACL00002121

unclassified

ACL00002122

HAD superfamily hydrolase related cluster

131

6e-07

22% (53/232)

GO:0003824|catalytic activity|IEA; GO:0008152|metabolism|IEA; GO:0016787|hydrolase activity|IEA

ACL00002123

Fts

Fused TOES related cluster

299

2e-26

35% (74/210)

GO:0004840|ubiquitin conjugating enzyme activity|IEA; GO:0006464|protein modification|IEA; GO:0006512|ubiquitin cycle|IEA; GO:0006915|apoptosis|IEA; GO:0016020|membrane|IEA

ACL00002124

unclassified

ACL00002125

Putative WD-40 repeat-protein related cluster

129

5e-07

40% (28/70)

General function prediction only

GO:0004871|signal transducer activity|IEA; GO:0005834|heterotrimeric G-protein complex|IEA; GO:0007186|G-protein coupled receptor protein signaling pathway|IEA

ACL00002126

GRIM-19 domain containing protein

123

2e-07

24% (27/111)

ACL00002127

unclassified

ACL00002128

Unknown EST

118

2e-06

43% (22/51)

ACL00002129

Unassigned protein

ACL00002130

Unassigned protein

148

5e-09

34% (32/94)

ACL00002131

unclassified

ACL00002132

Cell division control protein 45 homolog related cluster

200

2e-15

35% (48/135)

GO:0000074|regulation of cell cycle|IEA; GO:0005634|nucleus|IEA; GO:0005656|pre-replicative complex|IDA; GO:0006260|DNA replication|IEA; GO:0006270|DNA replication initiation|IEA; GO:0007049|cell cycle|IEA

ACL00002133

unclassified

ACL00002134

maf

Maf-like protein CPE2145 related cluster

132

2e-07

66% (24/36)

GO:0005554|molecular_function unknown|IEA

ACL00002135

unclassified

ACL00002136

unclassified

ACL00002137

Unassigned protein

ACL00002138

Putative glutamyl-tRNA synthetase related cluster

353

6e-33

50% (70/139)

Translation, ribosomal structure and biogenesis

GO:0004812|tRNA ligase activity|IEA; GO:0004818|glutamate-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0005737|cytoplasm|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006418|tRNA aminoacylation for protein translation|IEA; GO:0006424|glutamyl-tRNA aminoacylation|IEA; GO:0016874|ligase activity|IEA

ACL00002139

unclassified

ACL00002141

unclassified

ACL00002142

Coq6

Ubiquinone biosynthesis monooxgenase COQ6 related cluster

329

5e-30

53% (64/120)

1,4-Dichlorobenzene degradation Androgen and estrogen metabolism Bile acid biosynthesis Biosynthesis of steroids Histidine metabolism Limonene and pinene degradation Methane metabolism Nitrobenzene degradation Phenylalanine metabolism Stilbene, coumarine and lignin biosynthesis Styrene degradation Tryptophan metabolism Tyrosine metabolism Ubiquinone biosynthesis gamma-Hexachlorocyclohexane degradation

GO:0004497|monooxygenase activity|IEA; GO:0005615|extracellular space|TAS; GO:0006118|electron transport|IEA; GO:0006725|aromatic compound metabolism|IEA; GO:0006744|ubiquinone biosynthesis|IEA; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00002145

50S ribosomal protein L24 related cluster

56

2e-21

50% (9/18)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00002146

Clathrin assembly protein AP19, small subunit related cluster

149

4e-34

59% (25/42)

Intracellular trafficking, secretion, and vesicular transport

GO:0006886|intracellular protein transport|IEA; GO:0030125|clathrin vesicle coat|IEA

ACL00002147

multi-domain protein

159

7e-12

49% (33/67)

ACL00002148

unclassified

ACL00002149

multi-domain protein

129

2e-08

51% (25/49)

ACL00002150

Unassigned protein

ACL00002151

Unassigned protein

ACL00002152

unclassified

ACL00002153

unclassified

ACL00002154

unclassified

ACL00002155

GLA protein related cluster

150

2e-09

34% (43/126)

GO:0008080|N-acetyltransferase activity|IEA

ACL00002156

Ras suppressor protein 1 related cluster

135

6e-08

42% (26/61)

GO:0007165|signal transduction|TAS

ACL00002157

unclassified

ACL00002158

Calmodulin related cluster

236

1e-19

39% (42/107)

Phosphatidylinositol signaling system

GO:0005509|calcium ion binding|IEA

ACL00002159

unclassified

ACL00002160

Lipoate protein ligase-like protein related cluster

277

2e-24

46% (61/130)

6.-.-.-

Coenzyme transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0006464|protein modification|IEA; GO:0016874|ligase activity|IEA

ACL00002161

unclassified

ACL00002162

unclassified

ACL00002164

MOSC domain protein related cluster

385

3e-36

34% (99/289)

ACL00002165

unclassified

ACL00002166

Unknown EST

57

1e-21

47% (10/21)

ACL00002167

Adaptor-related protein complex 1, mu 1 subunit related cluster

514

1e-51

60% (97/161)

GO:0005794|Golgi apparatus|IEA; GO:0005905|coated pit|IEA; GO:0006810|transport|IEA; GO:0006886|intracellular protein transport|IEA; GO:0006897|endocytosis|IEA; GO:0015031|protein transport|IEA; GO:0030125|clathrin vesicle coat|IEA

ACL00002169

Unassigned protein

ACL00002170

multi-domain protein

128

5e-08

20% (45/216)

ACL00002171

Acid phosphatase related cluster

361

2e-33

42% (73/170)

GO:0003824|catalytic activity|IEA; GO:0008152|metabolism|IEA; GO:0016787|hydrolase activity|IEA

ACL00002172

Splicing variant of retinal degeneration B beta related cluster

193

5e-14

36% (42/115)

GO:0005622|intracellular|IEA; GO:0006810|transport|IEA

ACL00002173

unclassified

ACL00002174

unclassified

ACL00002175

[R] COG1574 Predicted metal-dependent hydrolase with the TIM-barrel fold

268

1e-23

42% (56/131)

General function prediction only

ACL00002176

Putative ankyrin repeat-containing protein related cluster

166

2e-11

48% (42/87)

General function prediction only

ACL00002177

unclassified

ACL00002178

unclassified

ACL00002179

unclassified

ACL00002180

unclassified

ACL00002181

CG3683

CG3683; CG3683 gene product from transcript CG3683-RA [EC:1.6.99.3] [KO:K00356]

138

7e-08

30% (29/95)

1.6.99.3

Oxidative phosphorylation

ACL00002182

phzF

Phenazine biosynthesis protein related cluster

260

4e-22

37% (62/167)

GO:0003824|catalytic activity|IEA; GO:0009058|biosynthesis|IEA

ACL00002183

MGC4399

Mitochondrial carrier protein related cluster

262

3e-22

38% (63/162)

GO:0005488|binding|IEA; GO:0005743|mitochondrial inner membrane|IEA; GO:0006810|transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA

ACL00002184

unclassified

ACL00002185

unclassified

ACL00002186

CTP:phosphorylcholine cytidylyltransferase related cluster

201

2e-15

43% (56/130)

GO:0004105|choline-phosphate cytidylyltransferase activity|IEA; GO:0009058|biosynthesis|IEA; GO:0016740|transferase activity|IEA; GO:0016779|nucleotidyltransferase activity|IEA

ACL00002187

Unknown EST

145

3e-10

100% (24/24)

ACL00002188

SRM

Spermidine synthase related cluster

125

5e-06

57% (23/40)

2.5.1.16

Amino acid transport and metabolism

Arginine and proline metabolism Urea cycle and metabolism of amino groups beta-Alanine metabolism

GO:0003824|catalytic activity|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00002189

5NTC

Cytosolic purine 5'-nucleotidase related cluster

220

2e-17

41% (44/105)

3.1.3.5

GO:0003824|catalytic activity|IEA; GO:0005829|cytosol|NR; GO:0008253|5'-nucleotidase activity|IEA; GO:0008253|5'-nucleotidase activity|TAS; GO:0016787|hydrolase activity|IEA

ACL00002190

Bmi1 upstream related cluster

142

1e-08

29% (35/118)

ACL00002191

Luminal binding protein precursor related cluster

407

1e-124

51% (75/145)

GO:0005524|ATP binding|IEA; GO:0005783|endoplasmic reticulum|IEA

ACL00002192

unclassified

ACL00002194

unclassified

ACL00002195

KIAA1219

Protein KIAA1219 related cluster

165

2e-11

44% (41/93)

GO:0005096|GTPase activator activity|IEA

ACL00002196

p44S10

26S proteasome non-ATPase regulatory subunit 6 related cluster

908

7e-97

59% (176/298)

Posttranslational modification, protein turnover, chaperones

Proteasome

GO:0000502|proteasome complex (sensu Eukaryota)|NAS; GO:0005488|binding|IEA; GO:0005829|cytosol|IEA; GO:0006510|ATP-dependent proteolysis|NAS; GO:0016887|ATPase activity|NAS

ACL00002197

Complex1_LYR domain containing protein

126

8e-08

38% (23/59)

ACL00002198

unclassified

ACL00002199

unclassified

ACL00002200

unclassified

ACL00002201

unclassified

ACL00002204

Ribosome biogenesis protein Brix related cluster

175

7e-40

50% (38/75)

Translation, ribosomal structure and biogenesis

GO:0005634|nucleus|IEA; GO:0007046|ribosome biogenesis|IEA

ACL00002206

unclassified

ACL00002207

fixL

Sensor protein fixL related cluster

263

4e-22

34% (57/164)

GO:0000155|two-component sensor molecule activity|IEA; GO:0000160|two-component signal transduction system (phosphorelay)|IEA; GO:0004871|signal transducer activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0007165|signal transduction|IEA; GO:0007600|sensory perception|IEA; GO:0009399|nitrogen fixation|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016301|kinase activity|IEA; GO:0016310|phosphorylation|IEA; GO:0016740|transferase activity|IEA; GO:0016772|transferase activity, transferring phosphorus-containing groups|IEA; GO:0019866|inner membrane|IEA

ACL00002209

Endopeptidase 24.16 related cluster

528

4e-53

59% (108/183)

GO:0004222|metalloendopeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008237|metallopeptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00002210

CSK

Tyrosine-protein kinase CSK related cluster

143

2e-08

42% (35/83)

2.7.1.112

Integrin-mediated cell adhesion Regulation of actin cytoskeleton

GO:0000074|regulation of cell cycle|TAS; GO:0004672|protein kinase activity|IEA; GO:0004713|protein-tyrosine kinase activity|IEA; GO:0004713|protein-tyrosine kinase activity|TAS; GO:0005524|ATP binding|IEA; GO:0005737|cytoplasm|NR; GO:0006468|protein amino acid phosphorylation|IEA; GO:0006468|protein amino acid phosphorylation|TAS; GO:0007242|intracellular signaling cascade|IEA; GO:0008022|protein C-terminus binding|TAS; GO:0016740|transferase activity|IEA

ACL00002211

unclassified

ACL00002213

unclassified

ACL00002214

Phosphoglucose isomerase related cluster

410

8e-40

68% (77/112)

Carbohydrate transport and metabolism

GO:0004347|glucose-6-phosphate isomerase activity|IEA; GO:0006094|gluconeogenesis|IEA; GO:0006096|glycolysis|IEA; GO:0016853|isomerase activity|IEA

ACL00002215

unclassified

ACL00002216

NUDT5

ADP-sugar pyrophosphatase related cluster

325

8e-30

40% (62/152)

3.6.1.13

GO:0000287|magnesium ion binding|IEA; GO:0005515|protein binding|NAS; GO:0005622|intracellular|NAS; GO:0016787|hydrolase activity|IEA; GO:0019144|ADP-sugar diphosphatase activity|IDA; GO:0019303|D-ribose catabolism|NAS

ACL00002217

unclassified

ACL00002218

unclassified

ACL00002220

unclassified

ACL00002221

unclassified

ACL00002223

unclassified

ACL00002224

unclassified

ACL00002225

RB-binding protein related cluster

145

6e-09

43% (29/66)

GO:0003677|DNA binding|IEA; GO:0005622|intracellular|IEA; GO:0005634|nucleus|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA

ACL00002226

Cytochrome b5 reductase isoform II related cluster

286

2e-25

38% (58/151)

1.6.2.2

Aminosugars metabolism

GO:0006118|electron transport|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00002227

unclassified

ACL00002228

Predicted flavin-nucleotide-binding protein related cluster

153

5e-10

34% (31/90)

General function prediction only

ACL00002229

multi-domain protein

116

1e-06

19% (38/193)

ACL00002230

Similar to seryl-tRNA synthetase, cytoplasmic related cluster

357

4e-33

38% (100/262)

Translation, ribosomal structure and biogenesis

GO:0000160|two-component signal transduction system (phosphorelay)|IEA; GO:0003677|DNA binding|IEA; GO:0005525|GTP binding|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006886|intracellular protein transport|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00002232

unclassified

ACL00002233

putative S-adenosyl methionine dependent methyltransferase like protein

331

2e-30

43% (73/167)

ACL00002235

unclassified

ACL00002236

Herpes_gp2 domain containing protein

122

3e-07

24% (41/165)

ACL00002237

Cwf15 / Cwc15 cell cycle control family protein [Arabidopsis thaliana] dbj|BAB01412.1| unnamed protein product [Arabidopsis thaliana]

184

3e-13

64% (36/56)

ACL00002238

idnO1

Putative 5-keto-D-gluconate 5-reductase protein related cluster

181

3e-13

47% (38/80)

1.1.1.69

GO:0008152|metabolism|IEA; GO:0008874|gluconate 5-dehydrogenase activity|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00002239

Cytosol aminopeptidase, putative related cluster

66

2e-59

40% (19/47)

3.4.11.1

Amino acid transport and metabolism

GO:0004177|aminopeptidase activity|IEA; GO:0004178|leucyl aminopeptidase activity|IEA; GO:0005622|intracellular|IEA; GO:0005737|cytoplasm|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0019538|protein metabolism|IEA; GO:0030145|manganese ion binding|IEA

ACL00002240

unclassified

ACL00002241

ITSN2

Intersectin 2 related cluster

160

8e-11

53% (26/49)

GO:0005070|SH3/SH2 adaptor protein activity|TAS; GO:0005509|calcium ion binding|IEA; GO:0006897|endocytosis|IEA

ACL00002242

multi-domain protein

94

1e-05

29% (22/74)

ACL00002243

yfmJ

YFMJ protein related cluster

470

2e-46

47% (98/208)

GO:0004024|alcohol dehydrogenase activity, zinc-dependent|IEA; GO:0008270|zinc ion binding|IEA

ACL00002244

unclassified

ACL00002246

BCS1L

Mitochondrial chaperone BCS1 related cluster

403

2e-38

45% (91/198)

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0005739|mitochondrion|IEA; GO:0006457|protein folding|IEA; GO:0016021|integral to membrane|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA; GO:0051082|unfolded protein binding|IEA

ACL00002247

unclassified

ACL00002248

unclassified

ACL00002249

Isochorismatase related cluster

281

9e-25

45% (55/121)

GO:0003824|catalytic activity|IEA; GO:0008152|metabolism|IEA; GO:0008908|isochorismatase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00002251

unclassified

ACL00002253

unclassified

ACL00002254

Unknown EST

108

8e-06

46% (23/49)

ACL00002255

ADP,ATP carrier protein related cluster

723

2e-75

48% (142/292)

GO:0005215|transporter activity|IEA; GO:0005471|ATP:ADP antiporter activity|IGI; GO:0005488|binding|IEA; GO:0005739|mitochondrion|IEA; GO:0005743|mitochondrial inner membrane|IEA; GO:0005743|mitochondrial inner membrane|IGI; GO:0006810|transport|IEA; GO:0006839|mitochondrial transport|IGI; GO:0009060|aerobic respiration|IGI; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0019866|inner membrane|IEA

ACL00002256

unclassified

ACL00002257

unclassified

ACL00002258

Dimethyladenosine transferase related cluster

686

2e-71

68% (127/186)

Translation, ribosomal structure and biogenesis

GO:0000154|rRNA modification|IEA; GO:0000179|rRNA (adenine-N6,N6-)-dimethyltransferase activity|IEA; GO:0006364|rRNA processing|IEA; GO:0008168|methyltransferase activity|IEA; GO:0008649|rRNA methyltransferase activity|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00002259

unclassified

ACL00002260

TPP1

Trehalose-phosphatase related cluster

313

6e-28

31% (82/262)

3.1.3.12

Carbohydrate transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0003825|alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity|IEA; GO:0004805|trehalose-phosphatase activity|IEA; GO:0005992|trehalose biosynthesis|IEA; GO:0008152|metabolism|IEA; GO:0016787|hydrolase activity|IEA

ACL00002262

unclassified

ACL00002263

Aspartyl aminopeptidase-like protein related cluster

425

1e-41

60% (81/135)

3.4.11.21

Amino acid transport and metabolism

GO:0004177|aminopeptidase activity|IEA; GO:0004250|aminopeptidase I activity|IEA; GO:0005773|vacuole|IEA; GO:0006508|proteolysis and peptidolysis|IEA

ACL00002264

unclassified

ACL00002265

unclassified

ACL00002266

Sas10_Utp3 domain containing protein

116

6e-07

38% (21/55)

ACL00002267

Ribosomal protein L34-like protein related cluster

91

4e-17

51% (14/27)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00002268

unclassified

ACL00002269

tRNA_m1G_MT_9 domain containing protein

115

1e-06

25% (18/70)

ACL00002270

unclassified

ACL00002271

unclassified

ACL00002272

Unassigned protein

ACL00002273

unclassified

ACL00002274

unclassified

ACL00002275

TTL domain containing protein

171

4e-13

24% (29/119)

ACL00002276

CG3057

Congested-like trachea protein related cluster

279

2e-24

57% (54/94)

GO:0005215|transporter activity|IEA; GO:0005215|transporter activity|ISS; GO:0005488|binding|IEA; GO:0005739|mitochondrion|IEA; GO:0005740|mitochondrial membrane|ISS; GO:0005743|mitochondrial inner membrane|IEA; GO:0006810|transport|IEA; GO:0006839|mitochondrial transport|ISS; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0019866|inner membrane|IEA

ACL00002277

multi-domain protein

122

3e-07

33% (32/96)

ACL00002278

unclassified

ACL00002279

Histone H1 related cluster

155

3e-10

49% (40/81)

GO:0000786|nucleosome|IEA; GO:0003677|DNA binding|IEA; GO:0005516|calmodulin binding|IEA; GO:0005634|nucleus|IEA; GO:0005694|chromosome|IEA; GO:0006334|nucleosome assembly|IEA; GO:0007001|chromosome organization and biogenesis (sensu Eukaryota)|IEA

ACL00002280

Epithelial protein lost in neoplasm related cluster

147

3e-09

51% (29/56)

GO:0008270|zinc ion binding|IEA

ACL00002282

Rpl8

Ribosomal protein L related cluster

151

2e-73

81% (27/33)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00002284

Rps11

40S ribosomal protein S11 related cluster

241

5e-20

69% (47/68)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003723|RNA binding|TAS; GO:0003735|structural constituent of ribosome|TAS; GO:0005840|ribosome|TAS; GO:0006412|protein biosynthesis|TAS

ACL00002286

Polyubiquitin related cluster

980

1e-105

97% (195/199)

ACL00002291

unclassified

ACL00002294

inosine-uridine preferring nucleoside hydrolase family protein [Arabidopsis thaliana] gb|AAL84950.1| AT5g18860/F17K4_110 [Arabidopsis thaliana] gb|AAM91461.1| AT5g18860/F17K4_110 [Arabidopsis thaliana]

129

1e-06

37% (34/91)

ACL00002295

unclassified

ACL00002296

unclassified

ACL00002297

CG3320

Ras-related protein Rab-1A related cluster

643

3e-66

60% (120/198)

GO:0005525|GTP binding|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0005794|Golgi apparatus|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00002298

CG13852

CG13852; CG13852 gene product

166

1e-11

69% (29/42)

ACL00002299

Lysozyme II precursor related cluster

445

2e-43

46% (96/205)

ACL00002300

Major vault protein alpha related cluster

940

1e-100

73% (185/253)

GO:0030529|ribonucleoprotein complex|IEA

ACL00002305

LYSX

Lysozyme X precursor related cluster

118

8e-06

36% (32/87)

3.2.1.17

GO:0003796|lysozyme activity|IEA; GO:0003824|catalytic activity|IEA; GO:0005576|extracellular region|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0016787|hydrolase activity|IEA; GO:0016798|hydrolase activity, acting on glycosyl bonds|IEA; GO:0016998|cell wall catabolism|IEA; GO:0019835|cytolysis|IEA; GO:0042742|defense response to bacteria|IEA

ACL00002306

DUF393 domain containing protein

159

1e-11

31% (28/88)

ACL00002307

PPCM

Phosphoenolpyruvate carboxykinase, mitochondrial precursor [GTP] related cluster

525

1e-52

46% (102/220)

4.1.1.32

Energy production and conversion

Citrate cycle (TCA cycle) Pyruvate metabolism

GO:0004611|phosphoenolpyruvate carboxykinase activity|IEA; GO:0004611|phosphoenolpyruvate carboxykinase activity|TAS; GO:0004613|phosphoenolpyruvate carboxykinase (GTP) activity|IEA; GO:0005525|GTP binding|IEA; GO:0005739|mitochondrion|IEA; GO:0005739|mitochondrion|TAS; GO:0006006|glucose metabolism|NR; GO:0006094|gluconeogenesis|IEA; GO:0016829|lyase activity|IEA; GO:0016831|carboxy-lyase activity|IEA; GO:0030145|manganese ion binding|IEA

ACL00002308

crt-1

Calreticulin precursor related cluster

226

3e-18

58% (44/75)

GO:0005509|calcium ion binding|IEA; GO:0005529|sugar binding|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0006457|protein folding|IEA; GO:0051082|unfolded protein binding|IEA

ACL00002311

BCAS2

BCAS2; breast carcinoma amplified sequence 2

120

4e-06

32% (25/76)

ACL00002312

unclassified

ACL00002313

Unknown EST

82

1e-08

60% (14/23)

ACL00002314

P4Hc domain containing protein

157

8e-13

23% (30/130)

ACL00002315

Luminal binding protein 3 precursor related cluster

281

7e-25

77% (54/70)

GO:0005524|ATP binding|IEA; GO:0005783|endoplasmic reticulum|IEA

ACL00002316

unclassified

ACL00002317

Cyclic GMP-binding protein C related cluster

235

2e-19

50% (50/99)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0004713|protein-tyrosine kinase activity|IEA; GO:0005085|guanyl-nucleotide exchange factor activity|IEA; GO:0005524|ATP binding|IEA; GO:0005525|GTP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0007242|intracellular signaling cascade|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00002320

zgc:56139

zgc:56139; similar to DEAD (Asp-Glu-Ala-Asp) box polypeptide 48

376

5e-36

89% (69/77)

ACL00002324

Ras-related protein Rab7 related cluster

234

2e-19

66% (46/69)

GO:0000160|two-component signal transduction system (phosphorelay)|IEA; GO:0003677|DNA binding|IEA; GO:0005525|GTP binding|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00002325

Rps15a

40S ribosomal protein S15a related cluster

419

7e-41

78% (75/96)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003723|RNA binding|TAS; GO:0003735|structural constituent of ribosome|TAS; GO:0005843|cytosolic small ribosomal subunit (sensu Eukaryota)|TAS; GO:0006412|protein biosynthesis|TAS

ACL00002327

Psmd11

26S proteasome non-ATPase regulatory subunit 11 related cluster

137

2e-75

61% (26/42)

Posttranslational modification, protein turnover, chaperones

Proteasome

GO:0005488|binding|IEA; GO:0005829|cytosol|IEA

ACL00002329

Putative nucleosome assembly protein 1 related cluster

126

2e-06

28% (34/120)

GO:0005634|nucleus|IEA; GO:0006334|nucleosome assembly|IEA

ACL00002330

3-methylcrotonyl-CoA carboxylase, beta subunit, putative related cluster

373

3e-35

77% (69/89)

Lipid transport and metabolism

GO:0004075|biotin carboxylase activity|IEA; GO:0009343|biotin carboxylase complex|IEA

ACL00002331

RPL11B

60S ribosomal protein L11 related cluster

614

6e-63

67% (114/169)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003723|RNA binding|TAS; GO:0003735|structural constituent of ribosome|TAS; GO:0005842|cytosolic large ribosomal subunit (sensu Eukaryota)|TAS; GO:0006412|protein biosynthesis|TAS

ACL00002336

unclassified

ACL00002339

Tubulin beta-1 chain related cluster

541

2e-54

68% (102/148)

Cytoskeleton

GO:0003924|GTPase activity|IEA; GO:0005198|structural molecule activity|IEA; GO:0005525|GTP binding|IEA; GO:0005634|nucleus|IEA; GO:0005874|microtubule|IEA; GO:0007018|microtubule-based movement|IEA; GO:0045298|tubulin|IEA; GO:0046785|microtubule polymerization|IEA

ACL00002340

grxC

Glutaredoxin 3 related cluster

221

1e-17

55% (44/80)

Posttranslational modification, protein turnover, chaperones

GO:0005489|electron transporter activity|IEA; GO:0006118|electron transport|IEA

ACL00002341

Similar to Kaposi's sarcoma-associated herpesvirus (KSHV) (Human herpesvirus 8). latent nuclear antigen related cluster

121

3e-06

33% (40/120)

ACL00002342

[K] COG5157 RNA polymerase II assessory factor

49

1e-21

36% (8/22)

Transcription

ACL00002343

UPF0220 domain containing protein

177

9e-14

29% (31/104)

ACL00002345

multi-domain protein

116

1e-06

32% (33/102)

ACL00002346

unclassified

ACL00002347

unclassified

ACL00002348

UCHL1

Ubiquitin carboxyl-terminal hydrolase isozyme L1 related cluster

74

6e-20

43% (16/37)

3.4.19.12

GO:0004197|cysteine-type endopeptidase activity|IDA; GO:0004221|ubiquitin thiolesterase activity|IEA; GO:0004221|ubiquitin thiolesterase activity|TAS; GO:0005622|intracellular|IEA; GO:0005737|cytoplasm|ISS; GO:0006511|ubiquitin-dependent protein catabolism|IEA; GO:0006511|ubiquitin-dependent protein catabolism|NR; GO:0006512|ubiquitin cycle|IEA; GO:0008234|cysteine-type peptidase activity|IEA; GO:0008242|omega peptidase activity|IDA; GO:0016579|protein deubiquitination|IDA; GO:0016787|hydrolase activity|IEA; GO:0043130|ubiquitin binding|IDA

ACL00002350

CCAAT-binding transcription factor subunit A related cluster

318

7e-29

74% (65/87)

GO:0003677|DNA binding|IEA; GO:0005634|nucleus|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA

ACL00002351

Similar to Mus musculus (Mouse). similar to S-adenosylmethionine decarboxylase 1 related cluster

703

6e-73

43% (141/325)

GO:0004014|adenosylmethionine decarboxylase activity|IEA; GO:0006597|spermine biosynthesis|IEA; GO:0008295|spermidine biosynthesis|IEA

ACL00002352

reduced viability upon starvation protein homolog

244

1e-19

24% (62/250)

ACL00002353

NUP62

Nuclear pore glycoprotein p62 related cluster

319

2e-28

34% (79/228)

GO:0005634|nucleus|IEA; GO:0005643|nuclear pore|IEA; GO:0005643|nuclear pore|TAS; GO:0006810|transport|IEA; GO:0017056|structural constituent of nuclear pore|IEA

ACL00002354

zgc:56616

Similar to peptidylprolyl isomerase (Cyclophilin)-like 2 related cluster

237

2e-19

42% (54/127)

Posttranslational modification, protein turnover, chaperones

GO:0000151|ubiquitin ligase complex|IEA; GO:0003755|peptidyl-prolyl cis-trans isomerase activity|IEA; GO:0004842|ubiquitin-protein ligase activity|IEA; GO:0006457|protein folding|IEA; GO:0016567|protein ubiquitination|IEA; GO:0016853|isomerase activity|IEA

ACL00002355

Iojap-related protein related cluster

187

9e-14

36% (39/108)

Function unknown

GO:0005554|molecular_function unknown|IEA

ACL00002356

multi-domain protein

124

1e-07

28% (30/107)

ACL00002357

CG2849

Ras-like protein 1 related cluster

456

1e-44

56% (89/157)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00002358

Eukaryotic translation initiation factor 4E-1 related cluster

230

3e-18

37% (44/117)

Translation, ribosomal structure and biogenesis

GO:0003723|RNA binding|IEA; GO:0003743|translation initiation factor activity|IEA; GO:0005737|cytoplasm|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006413|translational initiation|IEA; GO:0006417|regulation of protein biosynthesis|IEA; GO:0006445|regulation of translation|IEA

ACL00002359

D-3-phosphoglycerate dehydrogenase

622

5e-64

56% (110/194)

ACL00002361

multi-domain protein

115

3e-06

26% (39/150)

ACL00002362

unclassified

ACL00002363

MCT-1 protein-like related cluster

437

1e-42

50% (84/168)

GO:0003723|RNA binding|IEA

ACL00002364

Clathrin coat assembly protein AP17 related cluster

391

2e-37

64% (75/116)

Intracellular trafficking, secretion, and vesicular transport

GO:0005905|coated pit|IEA; GO:0006886|intracellular protein transport|IEA; GO:0030125|clathrin vesicle coat|IEA

ACL00002365

Ras-like protein rasS related cluster

270

6e-23

55% (54/98)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00002366

Unassigned protein

130

5e-07

25% (38/151)

ACL00002367

UBE2S

Ubiquitin-conjugating enzyme E2S related cluster

540

1e-54

68% (102/150)

6.3.2.19

Posttranslational modification, protein turnover, chaperones

GO:0004840|ubiquitin conjugating enzyme activity|IEA; GO:0004842|ubiquitin-protein ligase activity|IEA; GO:0006464|protein modification|IEA; GO:0006464|protein modification|TAS; GO:0006512|ubiquitin cycle|IEA; GO:0016874|ligase activity|IEA

ACL00002368

unclassified

ACL00002369

AKIN gamma related cluster

167

9e-11

25% (89/344)

ACL00002371

Polyubiquitin related cluster

1026

1e-110

97% (205/211)

ACL00002374

Histone H3 related cluster

405

5e-39

79% (83/104)

Chromatin structure and dynamics

GO:0000786|nucleosome|IEA; GO:0003677|DNA binding|IEA; GO:0005634|nucleus|IEA; GO:0005694|chromosome|IEA; GO:0006334|nucleosome assembly|IEA; GO:0007001|chromosome organization and biogenesis (sensu Eukaryota)|IEA

ACL00002378

similar to 4-methyl-5(B-hydroxyethyl)-thiazol monophosphate biosynthesis enzyme, closer

388

7e-37

50% (80/158)

ACL00002383

unclassified

ACL00002384

Spc18

Signal peptidase complex SPC-18 related cluster

257

1e-21

40% (65/159)

3.4.-.-

Intracellular trafficking, secretion, and vesicular transport

Protein export

GO:0006465|signal peptide processing|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008233|peptidase activity|IEA; GO:0008236|serine-type peptidase activity|IEA; GO:0016020|membrane|IEA

ACL00002385

Sugar_transport domain containing protein

119

9e-07

24% (25/103)

ACL00002389

CDIPT

CDP-diacylglycerol--inositol 3-phosphatidyltransferase related cluster

489

2e-48

48% (103/214)

2.7.8.11

Glycerolipid metabolism Phosphatidylinositol signaling system

GO:0000287|magnesium ion binding|IEA; GO:0003881|CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity|IEA; GO:0008526|phosphatidylinositol transporter activity|TAS; GO:0008654|phospholipid biosynthesis|IEA; GO:0016021|integral to membrane|IEA; GO:0016740|transferase activity|IEA; GO:0030145|manganese ion binding|IEA

ACL00002392

ODP2

Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial precursor related cluster

635

2e-65

59% (125/210)

2.3.1.12

Energy production and conversion

GO:0004742|dihydrolipoyllysine-residue acetyltransferase activity|IEA; GO:0005515|protein binding|IEA; GO:0005739|mitochondrion|IEA; GO:0006096|glycolysis|IEA; GO:0008152|metabolism|IEA; GO:0008415|acyltransferase activity|IEA; GO:0016740|transferase activity|IEA; GO:0045254|pyruvate dehydrogenase complex|IEA

ACL00002393

URIC

Probable uricase related cluster

479

3e-47

41% (105/255)

1.7.3.3

Secondary metabolites biosynthesis, transport and catabolism

GO:0004846|urate oxidase activity|IEA; GO:0006144|purine base metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00002395

Rps6

40S ribosomal protein S6 related cluster

813

1e-85

73% (154/210)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00002398

Eef1a1

Newt elongation factor 1-alpha related cluster

712

3e-74

83% (134/160)

3.6.5.3

Translation, ribosomal structure and biogenesis

GO:0003746|translation elongation factor activity|IEA; GO:0005525|GTP binding|IEA

ACL00002409

EEF1A2

Elongation factor 1-alpha related cluster

1874

0.0

78% (349/443)

3.6.5.3

Translation, ribosomal structure and biogenesis

GO:0003746|translation elongation factor activity|IEA; GO:0005525|GTP binding|IEA; GO:0005737|cytoplasm|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006414|translational elongation|IEA

ACL00002416

unclassified

ACL00002417

prp5

Pre-mRNA splicing protein prp5 related cluster

171

4e-12

31% (41/132)

GO:0000398|nuclear mRNA splicing, via spliceosome|IEA; GO:0005634|nucleus|IEA; GO:0006397|mRNA processing|IEA; GO:0007049|cell cycle|IEA

ACL00002418

unclassified

ACL00002419

XIAP associated factor-1 related cluster

122

2e-06

36% (25/69)

GO:0008270|zinc ion binding|IEA

ACL00002420

Centrin, putative related cluster

138

7e-08

25% (38/148)

GO:0005509|calcium ion binding|IEA

ACL00002421

FOG: TPR repeat protein, SEL1 subfamily

156

3e-10

32% (48/149)

General function prediction only

ACL00002422

unclassified

ACL00002423

unclassified

ACL00002424

unclassified

ACL00002425

RPL3

Ribosomal protein L3 related cluster

121

1e-150

67% (21/31)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00002426

unclassified

ACL00002427

Similar to asparaginase related cluster

345

3e-32

54% (73/133)

GO:0004067|asparaginase activity|IEA; GO:0006520|amino acid metabolism|IEA

ACL00002428

Synaptobrevin-like V snare protein related cluster

224

5e-18

46% (46/99)

Intracellular trafficking, secretion, and vesicular transport

ACL00002429

unclassified

ACL00002430

Cyclic phosphodiesterase - like protein related cluster

140

4e-08

25% (44/170)

ACL00002432

DUF525 domain containing protein

111

1e-06

38% (21/54)

ACL00002433

Cytochrome b5 related cluster

196

5e-15

55% (36/65)

GO:0005792|microsome|IEA; GO:0006118|electron transport|IEA; GO:0016021|integral to membrane|IEA

ACL00002434

unclassified

ACL00002435

unclassified

ACL00002436

PGK

Phosphoglycerate kinase related cluster

771

4e-81

69% (150/216)

2.7.2.3

Carbohydrate transport and metabolism

Carbon fixation Glycolysis / Gluconeogenesis

GO:0004618|phosphoglycerate kinase activity|IEA; GO:0006096|glycolysis|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00002437

unclassified

ACL00002438

unclassified

ACL00002439

60S ribosomal protein L15 related cluster

621

2e-63

64% (113/175)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00002440

unclassified

ACL00002441

unclassified

ACL00002442

unclassified

ACL00002443

unclassified

ACL00002445

[R] COG2319 FOG: WD40 repeat

430

1e-42

57% (70/122)

General function prediction only

ACL00002446

PCTP-like protein related cluster

204

1e-15

30% (52/172)

ACL00002447

fixL

Sensor protein fixL related cluster

190

9e-14

29% (47/157)

GO:0000155|two-component sensor molecule activity|IEA; GO:0000160|two-component signal transduction system (phosphorelay)|IEA; GO:0004871|signal transducer activity|IEA; GO:0005524|ATP binding|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0007165|signal transduction|IEA; GO:0007600|sensory perception|IEA; GO:0009399|nitrogen fixation|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016301|kinase activity|IEA; GO:0016310|phosphorylation|IEA; GO:0016740|transferase activity|IEA; GO:0016772|transferase activity, transferring phosphorus-containing groups|IEA; GO:0019866|inner membrane|IEA

ACL00002448

multi-domain protein

139

4e-09

45% (18/40)

ACL00002449

unclassified

ACL00002450

unclassified

ACL00002451

unclassified

ACL00002452

unclassified

ACL00002453

DNAJC7

DnaJ homolog subfamily C member 7 related cluster

123

7e-06

25% (48/191)

GO:0005515|protein binding|TAS; GO:0006457|protein folding|IEA; GO:0006457|protein folding|TAS; GO:0051082|unfolded protein binding|IEA

ACL00002455

unclassified

ACL00002456

unclassified

ACL00002457

Contains similarity to Helicobacter pylori peptide methionine sulfoxide reductase related cluster

444

2e-43

64% (81/125)

Posttranslational modification, protein turnover, chaperones

ACL00002458

nanA

Probable N-acetylneuraminate lyase related cluster

151

9e-10

44% (35/79)

4.1.3.3

Aminosugars metabolism

GO:0008747|N-acetylneuraminate lyase activity|IEA; GO:0016829|lyase activity|IEA

ACL00002460

unclassified

ACL00002461

unclassified

ACL00002462

unclassified

ACL00002463

T1G11.6; potassium channel protein, putative

256

4e-22

56% (47/83)

ACL00002464

Unassigned protein

75

2e-06

57% (12/21)

ACL00002465

unclassified

ACL00002467

unclassified

ACL00002468

unclassified

ACL00002469

unclassified

ACL00002470

STAT protein related cluster

247

6e-62

66% (47/71)

GO:0007242|intracellular signaling cascade|IEA

ACL00002471

Mtx1

Metaxin 1 related cluster

121

3e-06

43% (28/64)

GO:0005739|mitochondrion|IEA; GO:0006810|transport|IEA; GO:0015031|protein transport|IEA; GO:0016021|integral to membrane|IEA; GO:0016021|integral to membrane|TAS; GO:0019867|outer membrane|IEA

ACL00002472

Erh

Enhancer of rudimentary homolog related cluster

300

7e-27

53% (53/99)

GO:0000074|regulation of cell cycle|TAS; GO:0006139|nucleobase, nucleoside, nucleotide and nucleic acid metabolism|TAS; GO:0006213|pyrimidine nucleoside metabolism|TAS

ACL00002473

Calcium-binding mitochondrial carrier Aralar1 related cluster

133

1e-07

45% (26/57)

GO:0005488|binding|IEA; GO:0005509|calcium ion binding|IEA; GO:0005739|mitochondrion|IEA; GO:0005743|mitochondrial inner membrane|IEA; GO:0006810|transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0019866|inner membrane|IEA

ACL00002474

START domain containing protein

156

3e-11

24% (42/175)

ACL00002475

CG6811

Rho GTPase activating protein 2 related cluster

194

1e-14

35% (54/153)

ACL00002477

EXOA

Exodeoxyribonuclease related cluster

351

6e-33

51% (68/132)

3.1.11.2

GO:0004518|nuclease activity|IEA; GO:0004519|endonuclease activity|IEA; GO:0004527|exonuclease activity|IEA; GO:0006281|DNA repair|IEA; GO:0008853|exodeoxyribonuclease III activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00002478

PFTB

Protein farnesyltransferase beta subunit related cluster

166

2e-11

63% (30/47)

2.5.1.58

Posttranslational modification, protein turnover, chaperones

GO:0003824|catalytic activity|IEA; GO:0004659|prenyltransferase activity|IEA; GO:0004660|protein farnesyltransferase activity|IDA; GO:0016740|transferase activity|IEA

ACL00002479

MAAI

Maleylacetoacetate isomerase related cluster

503

6e-50

54% (107/195)

2.5.1.18

Glutathione metabolism Styrene degradation Tyrosine metabolism

GO:0003824|catalytic activity|IEA; GO:0004364|glutathione transferase activity|IEA; GO:0004364|glutathione transferase activity|ISS; GO:0004364|glutathione transferase activity|TAS; GO:0004602|glutathione peroxidase activity|ISS; GO:0005737|cytoplasm|IEA; GO:0005739|mitochondrion|IDA; GO:0006559|L-phenylalanine catabolism|IEA; GO:0006559|L-phenylalanine catabolism|ISS; GO:0006559|L-phenylalanine catabolism|TAS; GO:0006572|tyrosine catabolism|IEA; GO:0006572|tyrosine catabolism|TAS; GO:0009072|aromatic amino acid family metabolism|IEA; GO:0016034|maleylacetoacetate isomerase activity|IEA; GO:0016034|maleylacetoacetate isomerase activity|ISS; GO:0016740|transferase activity|IEA; GO:0016853|isomerase activity|IEA

ACL00002480

unclassified

ACL00002481

unclassified

ACL00002482

T23O

Tryptophan 2,3-dioxygenase related cluster

137

4e-08

71% (27/38)

1.13.11.11

Tryptophan metabolism

GO:0004833|tryptophan 2,3-dioxygenase activity|IEA; GO:0006568|tryptophan metabolism|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016702|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|IEA

ACL00002483

unclassified

ACL00002484

unclassified

ACL00002485

unclassified

ACL00002486

similar to guanine nucleotide exchange factor

205

8e-16

37% (52/139)

ACL00002487

Unassigned protein

ACL00002488

U2 small nuclear ribonucleoprotein A' related cluster

308

5e-28

55% (62/111)

GO:0003723|RNA binding|IEA; GO:0005634|nucleus|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00002489

unclassified

ACL00002490

unclassified

ACL00002491

unclassified

ACL00002492

Pipeptidyl-peptidase VI related cluster

80

8e-12

46% (18/39)

3.4.22.-

GO:0016787|hydrolase activity|IEA

ACL00002493

Putative cytochrome b-561 related cluster

218

7e-17

29% (48/163)

GO:0006118|electron transport|IEA; GO:0016021|integral to membrane|IEA

ACL00002494

unclassified

ACL00002495

unclassified

ACL00002496

zgc:63801

Eukaryotic translation initiation factor 3 subunit 1 related cluster

172

1e-11

25% (57/222)

GO:0003743|translation initiation factor activity|IEA; GO:0003743|translation initiation factor activity|TAS; GO:0005852|eukaryotic translation initiation factor 3 complex|TAS; GO:0006412|protein biosynthesis|IEA; GO:0006446|regulation of translational initiation|TAS

ACL00002497

multi-domain protein

123

8e-08

31% (28/90)

ACL00002498

CSN complex subunit 2 related cluster

607

7e-62

41% (125/302)

Posttranslational modification, protein turnover, chaperones

GO:0005488|binding|IEA; GO:0005634|nucleus|IEA; GO:0007275|development|IEA; GO:0008180|signalosome complex|IEA

ACL00002499

unclassified

ACL00002500

DCE2

Glutamate decarboxylase, 65 kDa isoform related cluster

163

6e-92

37% (25/67)

4.1.1.15

Amino acid transport and metabolism

Alanine and aspartate metabolism Butanoate metabolism Glutamate metabolism Taurine and hypotaurine metabolism beta-Alanine metabolism

GO:0004351|glutamate decarboxylase activity|IEA; GO:0005515|protein binding|IPI; GO:0006520|amino acid metabolism|IEA; GO:0006540|glutamate decarboxylation to succinate|TAS; GO:0007268|synaptic transmission|IEA; GO:0007268|synaptic transmission|TAS; GO:0016829|lyase activity|IEA; GO:0016831|carboxy-lyase activity|IEA; GO:0042136|neurotransmitter biosynthesis|IEA

ACL00002501

unclassified

ACL00002502

Apospory-associated protein C related cluster

123

1e-32

63% (21/33)

GO:0004034|aldose 1-epimerase activity|IEA; GO:0006012|galactose metabolism|IEA

ACL00002505

unclassified

ACL00002506

UBIG

3-demethylubiquinone-9 3-methyltransferase related cluster

362

4e-34

47% (71/151)

2.1.1.64

Ubiquinone biosynthesis

GO:0006744|ubiquinone biosynthesis|IEA; GO:0008168|methyltransferase activity|IEA; GO:0008425|ubiquinone biosynthesis methyltransferase activity|IEA; GO:0008689|3-demethylubiquinone-9 3-O-methyltransferase activity|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00002507

FCAALL.85; YbaK/prolyl-tRNA synthetase-related

413

1e-39

46% (83/180)

ACL00002508

DUF862 domain containing protein

201

2e-16

37% (37/99)

ACL00002509

Alkylated DNA repair protein related cluster

283

4e-25

47% (56/117)

Replication, recombination and repair

ACL00002510

unclassified

ACL00002511

unclassified

ACL00002512

Leucine-rich repeat containing protein related cluster

158

1e-10

35% (32/90)

Function unknown

ACL00002513

Probable prefoldin subunit 3 related cluster

330

3e-30

47% (63/133)

GO:0005515|protein binding|IEA; GO:0006457|protein folding|IEA; GO:0016272|prefoldin complex|IEA; GO:0051082|unfolded protein binding|IEA

ACL00002514

unclassified

ACL00002515

XIAP associated factor-1-like protein related cluster

99

4e-12

32% (21/65)

GO:0003676|nucleic acid binding|IEA; GO:0005634|nucleus|IEA; GO:0008270|zinc ion binding|IEA

ACL00002516

C2 domain/GRAM domain-containing protein-like [Oryza sativa (japonica cultivar-group)] dbj|BAD10009.1| C2 domain/GRAM domain-containing protein-like [Oryza sativa (japonica cultivar-group)]

155

2e-09

40% (36/89)

ACL00002518

Magmas

Mitochondria-associated granulocyte macrophage CSF signaling molecule, mitochondrial precursor related cluster

127

5e-07

64% (25/39)

GO:0005554|molecular_function unknown|IEA; GO:0005739|mitochondrion|IEA

ACL00002519

Pectin acetylesterase related cluster

223

6e-18

36% (47/129)

ACL00002520

unclassified

ACL00002521

Unassigned protein

ACL00002522

unclassified

ACL00002524

Cytochrome C oxidase assembly protein ctaG related cluster

118

6e-06

41% (23/55)

Posttranslational modification, protein turnover, chaperones

Oxidative phosphorylation

GO:0005507|copper ion binding|IEA; GO:0008535|cytochrome c oxidase complex assembly|IEA; GO:0016021|integral to membrane|IEA

ACL00002525

BYSL

Bystin related cluster

323

1e-29

61% (63/103)

GO:0005515|protein binding|IEA; GO:0005737|cytoplasm|TAS; GO:0007155|cell adhesion|IEA; GO:0007155|cell adhesion|TAS; GO:0007565|pregnancy|TAS

ACL00002526

multi-domain protein

130

2e-08

47% (29/61)

ACL00002527

unclassified

ACL00002529

unclassified

ACL00002530

Unknown EST

65

8e-12

66% (12/18)

ACL00002531

Heat shock protein 10 related cluster

259

3e-22

50% (47/94)

GO:0005524|ATP binding|IEA; GO:0006457|protein folding|IEA; GO:0006986|response to unfolded protein|IEA; GO:0051082|unfolded protein binding|IEA

ACL00002532

Putative mitochondrial carrier protein related cluster

298

1e-26

42% (72/169)

GO:0005215|transporter activity|IEA; GO:0005488|binding|IEA; GO:0005743|mitochondrial inner membrane|IEA; GO:0006810|transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA

ACL00002533

C2 domain containing protein

134

1e-08

32% (32/97)

ACL00002535

Putative PRLI-interacting factor K related cluster

175

2e-12

26% (49/184)

GO:0003676|nucleic acid binding|IEA; GO:0005634|nucleus|IEA; GO:0006511|ubiquitin-dependent protein catabolism|IEA; GO:0008233|peptidase activity|IEA; GO:0008270|zinc ion binding|IEA

ACL00002536

unclassified

ACL00002537

PAP2 domain containing protein

122

4e-08

32% (16/49)

ACL00002538

unclassified

ACL00002539

F25I16.5; kelch repeat-containing protein

157

9e-10

30% (41/134)

ACL00002540

CRIP2

Cysteine-rich protein 2 related cluster

212

2e-16

50% (42/83)

GO:0008270|zinc ion binding|IEA; GO:0008270|zinc ion binding|TAS

ACL00002541

unclassified

ACL00002542

unclassified

ACL00002543

unclassified

ACL00002544

unclassified

ACL00002545

unclassified

ACL00002546

PP1/PP2A phosphatases pleiotropic regulator PRL1 related cluster

386

5e-37

67% (64/95)

ACL00002547

ATPase-like protein related cluster

47

4e-13

75% (9/12)

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

ACL00002548

RPC8

DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide related cluster

287

2e-25

47% (53/111)

2.7.7.6

Transcription

GO:0003899|DNA-directed RNA polymerase activity|IEA; GO:0003899|DNA-directed RNA polymerase activity|IEP; GO:0005515|protein binding|IDA; GO:0005634|nucleus|IEA; GO:0005654|nucleoplasm|IDA; GO:0005666|DNA-directed RNA polymerase III complex|IDA; GO:0006139|nucleobase, nucleoside, nucleotide and nucleic acid metabolism|IDA; GO:0006350|transcription|IEA; GO:0006383|transcription from Pol III promoter|IDA; GO:0016740|transferase activity|IEA

ACL00002549

Unassigned protein

ACL00002550

ASF1B

ASF1B; ASF1 anti-silencing function 1 homolog B (S. cerevisiae)

206

3e-16

50% (35/70)

ACL00002551

unclassified

ACL00002552

multi-domain protein

141

3e-09

22% (63/286)

ACL00002553

unclassified

ACL00002554

K6O8.2; haloacid dehalogenase-like hydrolase family

476

2e-47

72% (93/129)

ACL00002555

Fmo2

Weakly similar to dimethylaniline monooxygenase related cluster

209

3e-16

40% (52/130)

GO:0004497|monooxygenase activity|IEA; GO:0004499|dimethylaniline monooxygenase (N-oxide-forming) activity|IEA; GO:0005792|microsome|IEA; GO:0006118|electron transport|IEA; GO:0015036|disulfide oxidoreductase activity|IEA

ACL00002556

RAS-related protein RAB1BV related cluster

222

5e-18

48% (40/82)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00002557

unclassified

ACL00002558

Putative FAD dependent oxidoreductase related cluster

99

1e-18

45% (19/42)

GO:0006118|electron transport|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00002559

unclassified

ACL00002560

Protein kinase related cluster

169

7e-12

44% (38/85)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00002561

Usp domain containing protein

166

6e-13

48% (33/68)

ACL00002562

Slc25a12

Calcium-binding mitochondrial carrier protein Aralar1 related cluster

160

8e-11

43% (32/73)

GO:0005215|transporter activity|IEA; GO:0005488|binding|IEA; GO:0005509|calcium ion binding|IEA; GO:0005739|mitochondrion|IEA; GO:0005739|mitochondrion|TAS; GO:0005743|mitochondrial inner membrane|IEA; GO:0005887|integral to plasma membrane|TAS; GO:0006810|transport|IEA; GO:0006810|transport|TAS; GO:0015294|solute:cation symporter activity|TAS; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0019866|inner membrane|IEA

ACL00002563

Calcium-independent phospholipase A2 related cluster

154

1e-09

28% (50/173)

GO:0003824|catalytic activity|IEA; GO:0005524|ATP binding|NAS; GO:0005622|intracellular|IDA; GO:0005624|membrane fraction|IDA; GO:0005778|peroxisomal membrane|IDA; GO:0006631|fatty acid metabolism|IDA; GO:0045735|nutrient reservoir activity|IEA; GO:0047499|calcium-independent phospholipase A2 activity|IDA

ACL00002564

COesterase domain containing protein

116

1e-06

22% (27/119)

ACL00002565

unclassified

ACL00002567

unclassified

ACL00002568

Unassigned protein

118

6e-06

66% (26/39)

ACL00002569

multi-domain protein

115

1e-06

31% (27/87)

ACL00002570

putative blue fluorescent protein [EC:1.-.-.-]

122

2e-06

46% (24/52)

1.-.-.-

ACL00002572

Rnp24

COP-coated vesicle membrane protein P24 homolog related cluster

48

1e-31

37% (9/24)

GO:0006886|intracellular protein transport|IEA; GO:0008320|protein carrier activity|IEA; GO:0016020|membrane|IEA

ACL00002574

PSN domain containing protein

83

6e-05

20% (9/43)

ACL00002575

Probable possible programmed cell death protein, copy 2 related cluster

227

4e-18

35% (50/142)

GO:0005509|calcium ion binding|IEA

ACL00002576

XDH

Xanthine dehydrogenase related cluster

222

5e-18

51% (46/90)

1.1.1.204

Nucleotide transport and metabolism

GO:0004854|xanthine dehydrogenase activity|IEA; GO:0005489|electron transporter activity|IEA; GO:0005777|peroxisome|IEA; GO:0006118|electron transport|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0030151|molybdenum ion binding|IEA

ACL00002577

Similar to nuclear matrix protein NMP200 related to splicing factor PRP19 related cluster

440

5e-43

54% (81/149)

GO:0000151|ubiquitin ligase complex|IEA; GO:0004842|ubiquitin-protein ligase activity|IEA; GO:0016567|protein ubiquitination|IEA

ACL00002578

KH domain containing protein

143

1e-09

41% (19/46)

ACL00002579

ubiG

Methyl transferase related cluster

290

2e-25

36% (75/203)

2.1.1.64

Coenzyme transport and metabolism

Ubiquinone biosynthesis

GO:0006744|ubiquinone biosynthesis|IEA; GO:0008168|methyltransferase activity|IEA; GO:0008425|ubiquinone biosynthesis methyltransferase activity|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00002581

unclassified

ACL00002582

unclassified

ACL00002583

DUF953 domain containing protein

200

3e-16

31% (39/124)

ACL00002584

multi-domain protein

120

5e-07

18% (42/224)

ACL00002585

RNaseL inhibitor-like protein ABCE.1 related cluster

238

4e-19

29% (77/257)

General function prediction only

GO:0000166|nucleotide binding|IEA; GO:0005489|electron transporter activity|IEA; GO:0005506|iron ion binding|IEA; GO:0005524|ATP binding|IEA; GO:0006118|electron transport|IEA; GO:0016887|ATPase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

ACL00002586

PSN domain containing protein

87

5e-05

13% (11/79)

ACL00002587

Truncated alanine-tRNA ligase related cluster

281

2e-24

34% (69/198)

GO:0003676|nucleic acid binding|IEA; GO:0004813|alanine-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006419|alanyl-tRNA aminoacylation|IEA; GO:0016874|ligase activity|IEA

ACL00002590

PP4C

Serine/threonine protein phosphatase 4 catalytic subunit related cluster

341

2e-31

42% (70/166)

3.1.3.16

Signal transduction mechanisms

GO:0000226|microtubule cytoskeleton organization and biogenesis|NAS; GO:0004704|NF-kappaB-inducing kinase activity|NAS; GO:0004721|phosphoprotein phosphatase activity|IEA; GO:0004722|protein serine/threonine phosphatase activity|NAS; GO:0005634|nucleus|IEA; GO:0005634|nucleus|NAS; GO:0005813|centrosome|NAS; GO:0016787|hydrolase activity|IEA; GO:0030145|manganese ion binding|IEA; GO:0046872|metal ion binding|NAS

ACL00002591

SDA1 domain containing 1 [Homo sapiens] dbj|BAA91648.1| unnamed protein product [Homo sapiens]

148

6e-09

35% (48/135)

ACL00002592

unclassified

ACL00002593

unclassified

ACL00002594

Probable clathrin-associated adaptor complex medium chain related cluster

225

2e-51

62% (41/66)

GO:0006886|intracellular protein transport|IEA; GO:0030125|clathrin vesicle coat|IEA

ACL00002595

Unassigned protein

258

8e-22

35% (70/200)

ACL00002596

unclassified

ACL00002597

Smc4l1

Structural maintenance of chromosomes 4-like 1 protein related cluster

158

3e-10

50% (35/69)

GO:0000070|mitotic sister chromatid segregation|ISS; GO:0000796|condensin complex|ISS; GO:0005524|ATP binding|IEA; GO:0005524|ATP binding|ISS; GO:0005634|nucleus|IEA; GO:0005634|nucleus|ISS; GO:0005737|cytoplasm|ISS; GO:0007001|chromosome organization and biogenesis (sensu Eukaryota)|IEA; GO:0007001|chromosome organization and biogenesis (sensu Eukaryota)|ISS; GO:0007049|cell cycle|IEA; GO:0007067|mitosis|IEA; GO:0007076|mitotic chromosome condensation|IEA; GO:0007076|mitotic chromosome condensation|ISS; GO:0016887|ATPase activity|IEA; GO:0046982|protein heterodimerization activity|ISS

ACL00002598

26S proteasome regulatory particle non-ATPase subunit8 related cluster

367

8e-35

72% (62/85)

GO:0005829|cytosol|IEA

ACL00002599

unclassified

ACL00002600

[R] COG0488 ATPase components of ABC transporters with duplicated ATPase domains

150

7e-10

27% (41/150)

General function prediction only

ACL00002602

unclassified

ACL00002603

UDP1

UTP--glucose-1-phosphate uridylyltransferase 1 related cluster

452

2e-44

72% (89/123)

2.7.7.9

Carbohydrate transport and metabolism

Galactose metabolism Nucleotide sugars metabolism Pentose and glucuronate interconversions Starch and sucrose metabolism

GO:0003983|UTP-glucose-1-phosphate uridylyltransferase activity|IEA; GO:0003983|UTP-glucose-1-phosphate uridylyltransferase activity|TAS; GO:0005737|cytoplasm|NAS; GO:0008152|metabolism|IEA; GO:0016301|kinase activity|IEA; GO:0016310|phosphorylation|NAS; GO:0016740|transferase activity|IEA; GO:0016779|nucleotidyltransferase activity|IEA

ACL00002604

unclassified

ACL00002605

Mitochondrial 2-oxodicarboxylate carrier 2 related cluster

287

8e-66

48% (64/132)

GO:0005215|transporter activity|IEA; GO:0005342|organic acid transporter activity|IDA; GO:0005478|intracellular transporter activity|IDA; GO:0005488|binding|IEA; GO:0005739|mitochondrion|IEA; GO:0005743|mitochondrial inner membrane|IDA; GO:0005743|mitochondrial inner membrane|IEA; GO:0006810|transport|IEA; GO:0006839|mitochondrial transport|IDA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0019866|inner membrane|IEA

ACL00002606

Unassigned protein

ACL00002607

CG7583

C-terminal binding protein related cluster

373

4e-35

42% (86/202)

Wnt signaling pathway

GO:0005634|nucleus|IEA; GO:0006564|L-serine biosynthesis|IEA; GO:0016616|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|IEA

ACL00002608

unclassified

ACL00002609

Putative serine/threonine-protein kinase ctr1 related cluster

155

3e-10

46% (29/62)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0004713|protein-tyrosine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0008152|metabolism|IEA; GO:0016301|kinase activity|IEA; GO:0016597|amino acid binding|IEA; GO:0016740|transferase activity|IEA

ACL00002610

Unassigned protein

ACL00002611

unclassified

ACL00002613

unclassified

ACL00002614

unclassified

ACL00002616

Hps1

Hermansky-Pudlak syndrome 1 protein homolog related cluster

240

1e-19

29% (60/206)

GO:0006996|organelle organization and biogenesis|IMP; GO:0030318|melanocyte cell differentiation|IMP

ACL00002617

comA2

ComA operon protein 2 related cluster

206

1e-15

37% (47/125)

GO:0003824|catalytic activity|IEA

ACL00002618

UBE3A

Ubiquitin-protein ligase E3A related cluster

337

3e-68

52% (68/130)

6.3.2.-

Posttranslational modification, protein turnover, chaperones

Tryptophan metabolism

GO:0004840|ubiquitin conjugating enzyme activity|TAS; GO:0004842|ubiquitin-protein ligase activity|IEA; GO:0005622|intracellular|IEA; GO:0005634|nucleus|IEA; GO:0006464|protein modification|IEA; GO:0006508|proteolysis and peptidolysis|TAS; GO:0006511|ubiquitin-dependent protein catabolism|TAS; GO:0006512|ubiquitin cycle|IEA; GO:0007420|brain development|TAS; GO:0016874|ligase activity|IEA

ACL00002619

unclassified

ACL00002620

unclassified

ACL00002623

unclassified

ACL00002624

unclassified

ACL00002625

Guanine nucleotide-releasing factor 2 related cluster

355

5e-33

44% (72/163)

GO:0003779|actin binding|IEA; GO:0005085|guanyl-nucleotide exchange factor activity|IEA; GO:0007242|intracellular signaling cascade|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0017048|Rho GTPase binding|IEA; GO:0030036|actin cytoskeleton organization and biogenesis|IEA

ACL00002626

Unassigned protein

ACL00002627

unclassified

ACL00002628

Herpes_gp2 domain containing protein

118

8e-07

25% (50/193)

ACL00002629

Cope

Coatomer epsilon subunit related cluster

392

3e-37

38% (86/224)

GO:0005488|binding|IEA; GO:0005737|cytoplasm|IEA; GO:0005794|Golgi apparatus|IEA; GO:0006810|transport|IEA; GO:0006886|intracellular protein transport|IEA; GO:0008565|protein transporter activity|IEA; GO:0015031|protein transport|IEA; GO:0016020|membrane|IEA; GO:0019735|antimicrobial humoral response (sensu Vertebrata)|TAS

ACL00002630

Thoc1

THO complex subunit 1 related cluster

265

3e-22

29% (68/231)

GO:0000398|nuclear mRNA splicing, via spliceosome|IEA; GO:0003677|DNA binding|IEA; GO:0003723|RNA binding|IEA; GO:0005198|structural molecule activity|IEA; GO:0005515|protein binding|IEA; GO:0005634|nucleus|IEA; GO:0006397|mRNA processing|IEA; GO:0006406|mRNA-nucleus export|IEA; GO:0006810|transport|IEA; GO:0007165|signal transduction|IEA

ACL00002631

unclassified

ACL00002632

Cyp4c3

Cytochrome P450 CYP4 related cluster

356

7e-33

36% (80/219)

1.14.-.-

Secondary metabolites biosynthesis, transport and catabolism

Ascorbate and aldarate metabolism Fluorene degradation Limonene and pinene degradation Stilbene, coumarine and lignin biosynthesis gamma-Hexachlorocyclohexane degradation

GO:0004497|monooxygenase activity|IEA; GO:0006118|electron transport|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00002634

multi-domain protein

435

1e-43

72% (72/99)

ACL00002635

unclassified

ACL00002636

SYYC

Tyrosyl-tRNA synthetase related cluster

170

2e-40

60% (31/51)

6.1.1.1

Translation, ribosomal structure and biogenesis

GO:0000049|tRNA binding|IEA; GO:0003723|RNA binding|IEA; GO:0004812|tRNA ligase activity|IEA; GO:0004831|tyrosine-tRNA ligase activity|IEA; GO:0004831|tyrosine-tRNA ligase activity|TAS; GO:0004871|signal transducer activity|NAS; GO:0005153|interleukin-8 receptor binding|TAS; GO:0005524|ATP binding|IEA; GO:0005615|extracellular space|TAS; GO:0005625|soluble fraction|TAS; GO:0005737|cytoplasm|TAS; GO:0006412|protein biosynthesis|IEA; GO:0006418|tRNA aminoacylation for protein translation|IEA; GO:0006437|tyrosyl-tRNA aminoacylation|IEA; GO:0006437|tyrosyl-tRNA aminoacylation|TAS; GO:0006915|apoptosis|TAS; GO:0006928|cell motility|NR; GO:0016874|ligase activity|IEA

ACL00002637

unclassified

ACL00002638

Small integral membrane protein of lysosome/late endosome related cluster

158

2e-10

41% (28/68)

ACL00002639

unclassified

ACL00002640

Gamma-glutamyl transpeptidase related cluster

399

2e-38

53% (87/162)

Amino acid transport and metabolism

GO:0003840|gamma-glutamyltransferase activity|IEA

ACL00002641

WD40 domain containing protein

98

6e-06

50% (15/30)

ACL00002642

DRTS2

Bifunctional dihydrofolate reductase-thymidylate synthase 2 related cluster

494

1e-49

69% (91/131)

1.5.1.3

Nucleotide transport and metabolism

Folate biosynthesis One carbon pool by folate Pyrimidine metabolism

GO:0003824|catalytic activity|IEA; GO:0004146|dihydrofolate reductase activity|IEA; GO:0004799|thymidylate synthase activity|IEA; GO:0006231|dTMP biosynthesis|IEA; GO:0006545|glycine biosynthesis|IEA; GO:0006730|one-carbon compound metabolism|IEA; GO:0008168|methyltransferase activity|IEA; GO:0009165|nucleotide biosynthesis|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016740|transferase activity|IEA

ACL00002643

unclassified

ACL00002644

unclassified

ACL00002645

mecanosensory gene mec-8

183

8e-13

43% (35/80)

ACL00002646

CG2248

Rac related cluster

604

9e-62

63% (114/179)

Wnt signaling pathway

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00002647

Cct3

CCT chaperonin gamma subunit related cluster

604

4e-62

72% (116/160)

Posttranslational modification, protein turnover, chaperones

GO:0005524|ATP binding|IEA; GO:0006457|protein folding|IEA; GO:0051082|unfolded protein binding|IEA

ACL00002648

unclassified

ACL00002649

unclassified

ACL00002650

Tctex-1 domain containing protein

131

8e-09

56% (17/30)

ACL00002651

unclassified

ACL00002653

GDP-mannose transporter related cluster

316

2e-28

33% (69/208)

GO:0005351|sugar porter activity|IEA; GO:0005794|Golgi apparatus|IEA; GO:0006810|transport|IEA; GO:0016021|integral to membrane|IEA

ACL00002654

Hdac2

Putative histone deacetylase related cluster

292

9e-26

51% (53/102)

GO:0004407|histone deacetylase activity|IEA; GO:0005634|nucleus|IEA; GO:0016575|histone deacetylation|IEA

ACL00002656

Unassigned protein

ACL00002657

CBS domain containing protein

128

4e-08

45% (21/46)

ACL00002658

unclassified

ACL00002659

unclassified

ACL00002660

Unassigned protein

ACL00002661

unclassified

ACL00002662

unclassified

ACL00002663

NADH-ubiquinone oxidoreductase related cluster

169

7e-12

51% (38/74)

ACL00002664

DCD

Probable deoxycytidine triphosphate deaminase related cluster

242

5e-20

35% (58/163)

3.5.4.13

Nucleotide transport and metabolism

GO:0008829|dCTP deaminase activity|IEA; GO:0009117|nucleotide metabolism|IEA; GO:0009220|pyrimidine ribonucleotide biosynthesis|IEA; GO:0016787|hydrolase activity|IEA; GO:0046080|dUTP metabolism|IEA

ACL00002665

unclassified

ACL00002667

REGA

3',5'-cyclic-nucleotide phosphodiesterase regA related cluster

266

1e-22

31% (71/224)

3.1.4.17

GO:0000156|two-component response regulator activity|IEA; GO:0000160|two-component signal transduction system (phosphorelay)|IEA; GO:0003677|DNA binding|IEA; GO:0004114|3',5'-cyclic-nucleotide phosphodiesterase activity|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0007165|signal transduction|IEA; GO:0016787|hydrolase activity|IEA

ACL00002668

Unknown EST

112

2e-06

55% (22/40)

ACL00002669

[R] COG2319 FOG: WD40 repeat

132

1e-07

27% (42/154)

General function prediction only

ACL00002670

ShKT domain containing protein

91

4e-05

33% (14/42)

ACL00002671

unclassified

ACL00002672

unclassified

ACL00002673

Beta 2 subunit of 20S proteasome related cluster

719

7e-75

56% (139/246)

3.4.25.1

Posttranslational modification, protein turnover, chaperones

Proteasome

GO:0004175|endopeptidase activity|IEA; GO:0005829|cytosol|IEA; GO:0005839|proteasome core complex (sensu Eukaryota)|IEA; GO:0006511|ubiquitin-dependent protein catabolism|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00002674

Psa

Puromycin-sensitive aminopeptidase related cluster

695

4e-72

44% (140/318)

Amino acid transport and metabolism

GO:0004177|aminopeptidase activity|IEA; GO:0004177|aminopeptidase activity|TAS; GO:0004179|membrane alanyl aminopeptidase activity|IEA; GO:0005634|nucleus|IEA; GO:0005829|cytosol|TAS; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008237|metallopeptidase activity|IEA; GO:0008270|zinc ion binding|IEA; GO:0016787|hydrolase activity|IEA

ACL00002675

TT_ORF1 domain containing protein

110

1e-06

54% (25/46)

ACL00002679

YMC2

Carrier protein YMC2, mitochondrial precursor related cluster

186

2e-13

24% (59/240)

GO:0005488|binding|IEA; GO:0005739|mitochondrion|IEA; GO:0005743|mitochondrial inner membrane|IEA; GO:0006810|transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0019866|inner membrane|IEA

ACL00002680

NMNA3

Nicotinamide mononucleotide adenylyltransferase 3 related cluster

199

3e-15

37% (45/120)

2.7.7.1

Coenzyme transport and metabolism

Nicotinate and nicotinamide metabolism

GO:0000309|nicotinamide-nucleotide adenylyltransferase activity|IEA; GO:0005634|nucleus|IEA; GO:0009058|biosynthesis|IEA; GO:0009435|NAD biosynthesis|IEA; GO:0016740|transferase activity|IEA; GO:0016779|nucleotidyltransferase activity|IEA; GO:0019363|pyridine nucleotide biosynthesis|IEA

ACL00002682

AFG3L2

AFG3-like protein 2 related cluster

207

3e-16

63% (42/66)

3.4.24.-

GO:0000166|nucleotide binding|IEA; GO:0004222|metalloendopeptidase activity|IEA; GO:0005524|ATP binding|IEA; GO:0005739|mitochondrion|IEA; GO:0005739|mitochondrion|TAS; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008237|metallopeptidase activity|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016787|hydrolase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA; GO:0030163|protein catabolism|IEA; GO:0051082|unfolded protein binding|TAS

ACL00002683

guaB

IMP dehydrogenase/GMP reductase related cluster

556

3e-56

46% (109/235)

1.1.1.205

Purine metabolism

GO:0003824|catalytic activity|IEA; GO:0003938|IMP dehydrogenase activity|IEA; GO:0006164|purine nucleotide biosynthesis|IEA; GO:0006177|GMP biosynthesis|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00002684

Diacylglycerol acyltransferase related cluster

534

6e-54

51% (90/175)

Lipid transport and metabolism

GO:0004144|diacylglycerol O-acyltransferase activity|IEA; GO:0008415|acyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00002685

unclassified

ACL00002686

Putative beta-galactosidase precursor related cluster

157

2e-10

37% (31/82)

GO:0004565|beta-galactosidase activity|IEA; GO:0005529|sugar binding|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0009341|beta-galactosidase complex|IEA

ACL00002687

Penta-EF-hand Ca2+-binding protein related cluster

402

3e-38

44% (77/174)

GO:0005509|calcium ion binding|IEA

ACL00002688

unclassified

ACL00002689

unclassified

ACL00002690

Unassigned protein

307

1e-27

51% (68/132)

ACL00002691

unclassified

ACL00002692

unclassified

ACL00002693

pt

Phosphotyrosine protein phosphatase related cluster

191

3e-14

44% (42/94)

3.1.3.48

Signal transduction mechanisms

GO:0004725|protein tyrosine phosphatase activity|IEA; GO:0006470|protein amino acid dephosphorylation|IEA

ACL00002694

unclassified

ACL00002695

bglX

Beta-xylosidase B related cluster

144

8e-09

38% (42/110)

3.2.1.21

Carbohydrate transport and metabolism

Cyanoamino acid metabolism Starch and sucrose metabolism Stilbene, coumarine and lignin biosynthesis

GO:0004553|hydrolase activity, hydrolyzing O-glycosyl compounds|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0009044|xylan 1,4-beta-xylosidase activity|IEA; GO:0016787|hydrolase activity|IEA; GO:0016798|hydrolase activity, acting on glycosyl bonds|IEA

ACL00002696

Tat-interacting protein Tip30 related cluster

268

5e-23

39% (65/165)

ACL00002697

Flavoprotein wrbA related cluster

428

1e-41

58% (79/135)

General function prediction only

GO:0010181|FMN binding|IEA; GO:0016481|negative regulation of transcription|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00002698

multi-domain protein

139

1e-10

47% (22/46)

ACL00002699

Unknown EST

67

2e-06

57% (12/21)

ACL00002700

unclassified

ACL00002701

multi-domain protein

115

2e-07

51% (22/43)

ACL00002702

unclassified

ACL00002704

unclassified

ACL00002705

Unknown EST

113

1e-06

53% (16/30)

ACL00002706

unclassified

ACL00002707

unclassified

ACL00002708

GATA transcription factor 3 related cluster

153

5e-10

44% (25/56)

GO:0003700|transcription factor activity|IEA; GO:0005634|nucleus|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA

ACL00002709

unclassified

ACL00002710

Putative WD-repeat protein related cluster

306

1e-27

44% (62/138)

General function prediction only

ACL00002711

unclassified

ACL00002712

S-adenosyl-L-methionine:delta24-sterol-C- methyltransferase related cluster

163

3e-69

70% (28/40)

GO:0008168|methyltransferase activity|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00002713

Aminopeptidase N related cluster

266

5e-23

37% (57/153)

3.4.11.2

Amino acid transport and metabolism

Glutathione metabolism

GO:0004177|aminopeptidase activity|IEA; GO:0004179|membrane alanyl aminopeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA

ACL00002714

Dynamin B precursor related cluster

300

4e-26

28% (106/371)

General function prediction only

GO:0003924|GTPase activity|IEA; GO:0005525|GTP binding|IEA

ACL00002715

unclassified

ACL00002716

F-LANa

F-LANa; carcinoma related gene

493

6e-49

50% (96/191)

ACL00002718

D-3-phosphoglycerate dehydrogenase related cluster

55

1e-46

25% (11/44)

GO:0006564|L-serine biosynthesis|IEA; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016597|amino acid binding|IEA; GO:0016616|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|IEA

ACL00002719

PSA4

Proteasome subunit alpha type 4 related cluster

803

1e-84

63% (151/237)

3.4.25.1

Posttranslational modification, protein turnover, chaperones

Proteasome

GO:0004175|endopeptidase activity|IEA; GO:0005829|cytosol|IEA; GO:0005839|proteasome core complex (sensu Eukaryota)|IEA; GO:0006511|ubiquitin-dependent protein catabolism|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00002720

Developmental protein DG1118 related cluster

512

2e-51

68% (107/156)

GO:0005554|molecular_function unknown|IEA

ACL00002721

unclassified

ACL00002722

unclassified

ACL00002723

unclassified

ACL00002724

unclassified

ACL00002725

Shoot regeneration-related mitogen activated protein kinase kinase kinase related cluster

368

6e-35

53% (71/133)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00002727

CG7530

CG7530; CG7530 gene product from transcript CG7530-RA

194

2e-14

33% (42/125)

General function prediction only

ACL00002728

Cyclophilin related cluster

555

2e-56

65% (101/154)

Posttranslational modification, protein turnover, chaperones

GO:0003755|peptidyl-prolyl cis-trans isomerase activity|IEA; GO:0006457|protein folding|IEA; GO:0016853|isomerase activity|IEA

ACL00002729

Unassigned protein

147

2e-08

29% (46/158)

ACL00002730

unclassified

ACL00002731

dapF

Diaminopimelate epimerase related cluster

285

9e-25

32% (70/217)

5.1.1.7

Amino acid transport and metabolism

Lysine biosynthesis

GO:0008837|diaminopimelate epimerase activity|IEA; GO:0009089|lysine biosynthesis via diaminopimelate|IEA; GO:0016853|isomerase activity|IEA

ACL00002732

unclassified

ACL00002733

unclassified

ACL00002734

unclassified

ACL00002736

unclassified

ACL00002738

unclassified

ACL00002739

unclassified

ACL00002740

unclassified

ACL00002743

RPC10

DNA-directed RNA polymerases I, II, and III 7.0 kDa polypeptide related cluster

138

3e-08

53% (23/43)

2.7.7.6

Transcription

GO:0003677|DNA binding|IEA; GO:0003899|DNA-directed RNA polymerase activity|IEA; GO:0005634|nucleus|IEA; GO:0005665|DNA-directed RNA polymerase II, core complex|NR; GO:0005666|DNA-directed RNA polymerase III complex|NR; GO:0006350|transcription|IEA; GO:0006356|regulation of transcription from Pol I promoter|TAS; GO:0006366|transcription from Pol II promoter|TAS; GO:0006383|transcription from Pol III promoter|TAS; GO:0008270|zinc ion binding|TAS; GO:0016740|transferase activity|IEA

ACL00002744

LOC382123

Similar to deoxyhypusine synthase related cluster

486

2e-48

75% (90/120)

Posttranslational modification, protein turnover, chaperones

GO:0008612|hypusine biosynthesis from peptidyl-lysine|IEA

ACL00002745

multi-domain protein

128

9e-08

19% (52/272)

ACL00002746

Ras-related protein Rab7 related cluster

107

3e-17

73% (19/26)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00002747

Keratin_B2 domain containing protein

132

2e-08

25% (36/142)

ACL00002748

unclassified

ACL00002749

Tetraspannin domain containing protein

119

6e-07

23% (21/91)

ACL00002750

Similar to ubiquitin-protein isopeptide ligase related cluster

462

1e-45

55% (94/168)

Posttranslational modification, protein turnover, chaperones

GO:0004842|ubiquitin-protein ligase activity|IEA; GO:0005622|intracellular|IEA; GO:0006464|protein modification|IEA; GO:0006512|ubiquitin cycle|IEA

ACL00002751

Nonspecific lipid-transfer protein, mitochondrial precursor related cluster

438

1e-42

44% (85/192)

Lipid transport and metabolism

GO:0005498|sterol carrier activity|IEA; GO:0005498|sterol carrier activity|TAS; GO:0005739|mitochondrion|IEA; GO:0005777|peroxisome|IEA; GO:0005777|peroxisome|TAS; GO:0006694|steroid biosynthesis|TAS; GO:0006810|transport|IEA; GO:0006869|lipid transport|IEA; GO:0008289|lipid binding|IEA

ACL00002752

Ptplb

Protein tyrosine phosphatase-like protein PTPLB related cluster

195

7e-15

50% (33/66)

GO:0016021|integral to membrane|TAS

ACL00002753

Similar to putative mitochondrial rna splicing protein related cluster

420

4e-40

32% (112/349)

GO:0016020|membrane|IEA; GO:0030001|metal ion transport|IEA; GO:0046873|metal ion transporter activity|IEA

ACL00002754

unclassified

ACL00002756

unclassified

ACL00002757

unclassified

ACL00002758

METX

Homoserine O-acetyltransferase related cluster

269

2e-23

34% (54/156)

2.3.1.31

Amino acid transport and metabolism

Methionine metabolism Sulfur metabolism

GO:0004414|homoserine O-acetyltransferase activity|IEA; GO:0005737|cytoplasm|IEA; GO:0008415|acyltransferase activity|IEA; GO:0009086|methionine biosynthesis|IEA; GO:0016413|O-acetyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00002760

RIB2

DRAP deaminase related cluster

396

2e-37

33% (101/301)

GO:0003723|RNA binding|IEA; GO:0004730|pseudouridylate synthase activity|IEA; GO:0005737|cytoplasm|IDA; GO:0006396|RNA processing|IEA; GO:0008270|zinc ion binding|IEA; GO:0009231|riboflavin biosynthesis|IEA; GO:0009231|riboflavin biosynthesis|IMP; GO:0009982|pseudouridine synthase activity|IEA; GO:0016787|hydrolase activity|IEA; GO:0017173|DRAP deaminase activity|IGI

ACL00002761

COP9 subunit 4 related cluster

499

8e-50

58% (100/172)

GO:0005634|nucleus|IEA; GO:0008180|signalosome complex|IEA

ACL00002762

ADF domain containing protein

92

2e-05

15% (12/80)

ACL00002763

unclassified

ACL00002764

glnA4

Probable glutamine synthetase GLNA4 (Glutamine synthase) (GS-II) related cluster

74

2e-28

45% (14/31)

6.3.1.2

Amino acid transport and metabolism

Glutamate metabolism Nitrogen metabolism Peptidoglycan biosynthesis

GO:0004356|glutamate-ammonia ligase activity|IEA; GO:0006542|glutamine biosynthesis|IEA; GO:0006807|nitrogen compound metabolism|IEA; GO:0009399|nitrogen fixation|IEA; GO:0016874|ligase activity|IEA

ACL00002765

Commd10

Commd10; COMM domain containing 10

251

5e-21

33% (63/186)

ACL00002766

unclassified

ACL00002767

unclassified

ACL00002768

unclassified

ACL00002769

unclassified

ACL00002770

putative U3 snoRNP component

Probable involvement in pre rRNA processing, putative sik1 protein homolog related cluster

163

6e-44

62% (35/56)

GO:0019013|viral nucleocapsid|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00002771

unclassified

ACL00002772

GLK2

Probable glucokinase 2 related cluster

259

9e-22

35% (73/205)

2.7.1.2

GO:0004340|glucokinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006096|glycolysis|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00002773

unclassified

ACL00002774

ADP-ribosylation factor related cluster

152

4e-26

47% (34/71)

GO:0005525|GTP binding|IEA; GO:0005794|Golgi apparatus|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00002775

DGAT2

Diacylglycerol acyltransferase 2 related cluster

174

2e-12

35% (42/120)

GO:0004144|diacylglycerol O-acyltransferase activity|IDA; GO:0005624|membrane fraction|IDA; GO:0008415|acyltransferase activity|IEA; GO:0016740|transferase activity|IEA; GO:0019432|triacylglycerol biosynthesis|IDA

ACL00002776

ACES

Acetylcholinesterase precursor related cluster

217

4e-17

34% (52/149)

3.1.1.7

GO:0003824|catalytic activity|IEA; GO:0003990|acetylcholinesterase activity|IEA; GO:0004104|cholinesterase activity|IEA; GO:0004759|serine esterase activity|IEA; GO:0016020|membrane|IEA; GO:0016787|hydrolase activity|IEA; GO:0042135|neurotransmitter catabolism|IEA; GO:0045202|synapse|IEA

ACL00002777

ARK5

AMPK-related protein kinase 5 related cluster

74

9e-13

24% (18/74)

2.7.1.37

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016740|transferase activity|IEA

ACL00002778

unclassified

ACL00002779

Commd2

Commd2; COMM domain containing 2

222

4e-18

39% (43/108)

ACL00002780

Unassigned protein

169

1e-11

38% (46/120)

ACL00002781

unclassified

ACL00002783

GPDA

Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic related cluster

344

9e-32

54% (70/128)

1.1.1.8

Energy production and conversion

Glycerolipid metabolism

GO:0004367|glycerol-3-phosphate dehydrogenase (NAD+) activity|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0006072|glycerol-3-phosphate metabolism|IEA; GO:0009331|glycerol-3-phosphate dehydrogenase complex|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016614|oxidoreductase activity, acting on CH-OH group of donors|IEA

ACL00002784

unclassified

ACL00002785

Probable oxidoreductase related cluster

71

2e-12

34% (14/41)

GO:0006118|electron transport|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00002786

unclassified

ACL00002787

Neurula-specific ferrodoxin reductase-like protein related cluster

341

1e-31

45% (74/163)

GO:0006118|electron transport|IEA; GO:0015036|disulfide oxidoreductase activity|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00002788

Acetyltransferase-like protein related cluster

371

9e-35

48% (69/143)

GO:0008080|N-acetyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00002789

unclassified

ACL00002791

LimD related cluster

150

2e-09

31% (47/148)

GO:0008270|zinc ion binding|IEA

ACL00002792

UBPH

Gene product with similarity to ubiquitin binding enzyme related cluster

489

2e-48

47% (93/195)

ACL00002793

unclassified

ACL00002794

Penta-EF-hand Ca2+-binding protein related cluster

414

1e-39

47% (82/174)

GO:0005509|calcium ion binding|IEA

ACL00002795

unclassified

ACL00002796

Gamma-carboxymuconolactone decarboxylase related cluster

122

3e-06

39% (32/82)

4.1.1.44

Function unknown

Benzoate degradation via hydroxylation

GO:0003824|catalytic activity|IEA; GO:0006725|aromatic compound metabolism|IEA

ACL00002797

Kinase binding protein-like related cluster

281

4e-80

73% (56/76)

GO:0005737|cytoplasm|IEA; GO:0008168|methyltransferase activity|IEA; GO:0016301|kinase activity|IEA

ACL00002798

unclassified

ACL00002799

HEM3

Porphobilinogen deaminase related cluster

384

8e-37

61% (75/121)

2.5.1.61

Coenzyme transport and metabolism

Porphyrin and chlorophyll metabolism

GO:0004418|hydroxymethylbilane synthase activity|IEA; GO:0006779|porphyrin biosynthesis|IEA; GO:0015995|chlorophyll biosynthesis|IEA; GO:0016740|transferase activity|IEA

ACL00002800

unclassified

ACL00002801

unclassified

ACL00002802

ODPA

Pyruvate dehydrogenase E1 component alpha subunit, mitochondrial precursor related cluster

964

1e-103

61% (181/294)

1.2.4.1

Energy production and conversion

Butanoate metabolism Glycolysis / Gluconeogenesis Pyruvate metabolism Valine, leucine and isoleucine biosynthesis

GO:0004739|pyruvate dehydrogenase (acetyl-transferring) activity|IEA; GO:0005739|mitochondrion|IEA; GO:0006096|glycolysis|IEA; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016624|oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor|IEA

ACL00002803

multi-domain protein

190

3e-15

32% (45/139)

ACL00002804

unclassified

ACL00002805

Tymo_45kd_70kd domain containing protein

107

1e-05

18% (25/135)

ACL00002806

unclassified

ACL00002807

unclassified

ACL00002808

Unassigned protein

ACL00002809

unclassified

ACL00002810

Unassigned protein

126

5e-06

37% (35/93)

ACL00002813

unclassified

ACL00002814

unclassified

ACL00002815

Rab38

Ras-related protein Rab-38 related cluster

307

2e-27

51% (65/127)

GO:0003924|GTPase activity|NAS; GO:0005525|GTP binding|IEA; GO:0005525|GTP binding|NAS; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0007264|small GTPase mediated signal transduction|NAS; GO:0008372|cellular_component unknown|ND; GO:0015031|protein transport|IEA; GO:0015031|protein transport|NAS

ACL00002816

Mcee

Mcee; methylmalonyl CoA epimerase

467

4e-46

54% (94/172)

ACL00002817

Aldolase related cluster

471

2e-46

49% (96/195)

Carbohydrate transport and metabolism

ACL00002818

Ubiquitin-activating enzyme E1 related cluster

593

1e-60

57% (115/201)

Coenzyme transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0004839|ubiquitin activating enzyme activity|IEA; GO:0006464|protein modification|IEA; GO:0006512|ubiquitin cycle|IEA

ACL00002819

unclassified

ACL00002820

Heat shock protein 83 related cluster

505

1e-152

62% (100/159)

GO:0005524|ATP binding|IEA; GO:0006457|protein folding|IEA; GO:0006986|response to unfolded protein|IEA; GO:0051082|unfolded protein binding|IEA

ACL00002821

ubiE

Probable ubiquinone/menaquinone biosynthesis methyltransferase related cluster

485

5e-48

48% (101/207)

2.1.1.-

Aminophosphonate metabolism Androgen and estrogen metabolism Histidine metabolism Nitrobenzene degradation Selenoamino acid metabolism Tryptophan metabolism Tyrosine metabolism Ubiquinone biosynthesis

GO:0008168|methyltransferase activity|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00002822

unclassified

ACL00002823

ODPB

Pyruvate dehydrogenase E1 component beta subunit, mitochondrial precursor related cluster

115

1e-111

50% (23/46)

1.2.4.1

Energy production and conversion

GO:0004739|pyruvate dehydrogenase (acetyl-transferring) activity|IEA; GO:0005739|mitochondrion|IEA; GO:0006096|glycolysis|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00002824

Syn2

Synapsin isoform 8.2 related cluster

654

2e-67

41% (133/322)

GO:0007269|neurotransmitter secretion|IEA; GO:0008021|synaptic vesicle|IEA

ACL00002825

Similar to Yarrowia lipolytica (Candida lipolytica). alternative NADH-dehydrogenase related cluster

271

1e-23

54% (56/102)

Energy production and conversion

GO:0006118|electron transport|IEA; GO:0008137|NADH dehydrogenase (ubiquinone) activity|IEA; GO:0015036|disulfide oxidoreductase activity|IEA

ACL00002826

F26K24.22; universal stress protein (USP) family protein

146

2e-09

50% (27/53)

Signal transduction mechanisms

ACL00002827

Putative arginine N-methyltransferase related cluster

484

8e-48

48% (90/185)

GO:0008168|methyltransferase activity|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00002828

Galk2

N-acetylgalactosamine kinase related cluster

297

1e-26

42% (66/157)

Carbohydrate transport and metabolism

Galactose metabolism

GO:0004335|galactokinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0005737|cytoplasm|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0006012|galactose metabolism|IEA; GO:0008152|metabolism|IEA; GO:0016301|kinase activity|IEA; GO:0016310|phosphorylation|IEA; GO:0016740|transferase activity|IEA; GO:0016773|phosphotransferase activity, alcohol group as acceptor|IEA

ACL00002829

unclassified

ACL00002830

SODC

Superoxide dismutase [Cu-Zn] related cluster

238

2e-19

43% (62/142)

1.15.1.1

Inorganic ion transport and metabolism

GO:0004784|superoxide dismutase activity|IEA; GO:0004785|copper, zinc superoxide dismutase activity|IEA; GO:0006801|superoxide metabolism|IEA; GO:0016209|antioxidant activity|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0046872|metal ion binding|IEA

ACL00002831

unclassified

ACL00002832

Calpain-like cysteine protease related cluster

156

8e-10

24% (52/211)

GO:0004198|calpain activity|IEA; GO:0005622|intracellular|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008233|peptidase activity|IEA

ACL00002833

unclassified

ACL00002834

glbN

Cyanoglobin related cluster

274

1e-23

50% (54/108)

GO:0005344|oxygen transporter activity|IEA; GO:0006810|transport|IEA; GO:0015671|oxygen transport|IEA

ACL00002835

unclassified

ACL00002836

unclassified

ACL00002837

unclassified

ACL00002839

Putative phosphatidylinositol-4-phosphate 5-kinase, 11335-7537, possible related cluster

308

9e-28

37% (54/143)

GO:0016301|kinase activity|IEA

ACL00002840

unclassified

ACL00002841

unclassified

ACL00002842

unclassified

ACL00002843

Probable carbonic anhydrase related cluster

577

2e-58

52% (105/201)

4.2.1.1

Inorganic ion transport and metabolism

Nitrogen metabolism

GO:0004089|carbonate dehydratase activity|IEA; GO:0008270|zinc ion binding|IEA; GO:0015976|carbon utilization|IEA

ACL00002844

multi-domain protein

125

2e-07

23% (38/160)

ACL00002846

GAJ

GAJ related cluster

243

3e-20

31% (51/162)

ACL00002847

20S core proteasome subunit beta 5

752

7e-79

59% (143/241)

Posttranslational modification, protein turnover, chaperones

ACL00002848

Phosphoglucomutase/phosphomannomutase related cluster

196

6e-15

45% (49/108)

Carbohydrate transport and metabolism

GO:0005975|carbohydrate metabolism|IEA; GO:0016868|intramolecular transferase activity, phosphotransferases|IEA

ACL00002849

60S ribosomal protein L1 related cluster

175

4e-12

37% (43/116)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0003735|structural constituent of ribosome|TAS; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0005842|cytosolic large ribosomal subunit (sensu Eukaryota)|TAS; GO:0006412|protein biosynthesis|IEA; GO:0006412|protein biosynthesis|TAS

ACL00002850

[B] COG5648 Chromatin-associated proteins containing the HMG domain

121

1e-06

29% (26/87)

Chromatin structure and dynamics

ACL00002851

graD-1

Glucose-1-phosphate thymidylyltransferase related cluster

162

1e-10

35% (52/145)

2.7.7.24

Nucleotide sugars metabolism Polyketide sugar unit biosynthesis Streptomycin biosynthesis

GO:0009058|biosynthesis|IEA; GO:0016740|transferase activity|IEA; GO:0016779|nucleotidyltransferase activity|IEA

ACL00002852

Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family

157

1e-10

28% (42/148)

ACL00002853

multi-domain protein

114

3e-06

23% (41/176)

ACL00002854

zgc:56197

PCNA-like DNA checkpoint protein Rad9 related cluster

268

2e-23

39% (57/144)

GO:0000074|regulation of cell cycle|IEA; GO:0006281|DNA repair|IEA

ACL00002855

unclassified

ACL00002856

PSN domain containing protein

99

4e-06

20% (19/94)

ACL00002857

Unassigned protein

162

5e-11

30% (41/135)

ACL00002858

STK3

Serine/threonine-protein kinase 3 related cluster

259

1e-21

56% (51/91)

2.7.1.37

MAPK signaling pathway

GO:0000287|magnesium ion binding|IDA; GO:0000287|magnesium ion binding|IEA; GO:0004672|protein kinase activity|IEA; GO:0004672|protein kinase activity|TAS; GO:0004674|protein serine/threonine kinase activity|IDA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0004713|protein-tyrosine kinase activity|IEA; GO:0005515|protein binding|IEA; GO:0005524|ATP binding|IDA; GO:0005524|ATP binding|IEA; GO:0005634|nucleus|IEA; GO:0005737|cytoplasm|NR; GO:0006468|protein amino acid phosphorylation|IDA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0006915|apoptosis|IEA; GO:0006915|apoptosis|NR; GO:0007165|signal transduction|IEA; GO:0007165|signal transduction|TAS; GO:0007243|protein kinase cascade|IDA; GO:0016740|transferase activity|IEA; GO:0043065|positive regulation of apoptosis|ISS; GO:0046983|protein dimerization activity|ISS

ACL00002859

CBS domain-containing protein [Naegleria gruberi]

138

2e-07

27% (40/147)

ACL00002860

mrp

Mrp protein related cluster

190

3e-14

43% (37/86)

GO:0005524|ATP binding|IEA; GO:0005554|molecular_function unknown|IEA

ACL00002861

unclassified

ACL00002862

Tsn

Translin related cluster

54

2e-21

36% (9/25)

GO:0003677|DNA binding|IEA; GO:0005634|nucleus|IEA

ACL00002863

Protein kinase Npk related cluster

197

4e-15

44% (38/86)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0004713|protein-tyrosine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00002865

unclassified

ACL00002866

unclassified

ACL00002867

ABC transporter-like protein related cluster

172

4e-12

34% (37/107)

Defense mechanisms

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0016887|ATPase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

ACL00002868

unclassified

ACL00002869

unclassified

ACL00002870

Siahbp1

Ro ribonucleoprotein-binding protein 1 related cluster

206

8e-16

43% (42/96)

GO:0003723|RNA binding|IEA; GO:0019013|viral nucleocapsid|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00002871

ACT domain protein related cluster

163

1e-10

27% (47/171)

GO:0008152|metabolism|IEA; GO:0016597|amino acid binding|IEA

ACL00002872

unclassified

ACL00002874

cmfA

Conditioned medium factor related cluster

124

8e-20

66% (22/33)

ACL00002875

unclassified

ACL00002876

Putative zinc finger protein related cluster

133

2e-07

34% (25/72)

ACL00002877

Cysteine proteinase related cluster

139

2e-08

42% (33/77)

GO:0004197|cysteine-type endopeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008233|peptidase activity|IEA; GO:0008234|cysteine-type peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00002878

unclassified

ACL00002879

Similar to Sus scrofa (Pig). succinyl-CoA ligase related cluster

76

1e-31

73% (14/19)

Energy production and conversion

GO:0003824|catalytic activity|IEA; GO:0008152|metabolism|IEA; GO:0016874|ligase activity|IEA

ACL00002880

SYRC

Probable arginyl-tRNA synthetase, cytoplasmic related cluster

371

7e-35

43% (75/171)

6.1.1.19

Translation, ribosomal structure and biogenesis

Aminoacyl-tRNA biosynthesis Arginine and proline metabolism

GO:0004812|tRNA ligase activity|IEA; GO:0004814|arginine-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006418|tRNA aminoacylation for protein translation|IEA; GO:0006420|arginyl-tRNA aminoacylation|IEA; GO:0016874|ligase activity|IEA

ACL00002881

unclassified

ACL00002882

Putative ubiquitin-like protein related cluster

136

2e-07

58% (27/46)

Posttranslational modification, protein turnover, chaperones

ACL00002883

unclassified

ACL00002884

AAA ATPase related cluster

328

1e-29

43% (69/157)

Posttranslational modification, protein turnover, chaperones

GO:0000166|nucleotide binding|IEA; GO:0004176|ATP-dependent peptidase activity|IEA; GO:0004252|serine-type endopeptidase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

ACL00002885

unclassified

ACL00002886

Rnasel

2-5A-dependent ribonuclease related cluster

134

8e-08

32% (44/134)

3.1.26.-

GO:0003723|RNA binding|IEA; GO:0004518|nuclease activity|IEA; GO:0004519|endonuclease activity|IEA; GO:0004672|protein kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016787|hydrolase activity|IEA

ACL00002887

unclassified

ACL00002888

BLVR domain containing protein

111

7e-06

28% (44/152)

ACL00002889

unclassified

ACL00002890

Similar to Mus musculus (Mouse), and Rattus norvegicus (Rat). neuron specific calcium-binding protein hippocalcin related cluster

159

2e-10

48% (30/62)

GO:0005509|calcium ion binding|IEA

ACL00002891

Nup54

Nucleoporin p54 related cluster

289

3e-25

35% (69/192)

GO:0005634|nucleus|IEA; GO:0006810|transport|IEA

ACL00002892

unclassified

ACL00002893

Unassigned protein

143

6e-08

28% (63/218)

ACL00002894

Putative RanBP7/importin-beta/Cse1p superfamily RanGTP-binding protein related cluster

72

2e-10

46% (13/28)

Posttranslational modification, protein turnover, chaperones

GO:0000059|protein-nucleus import, docking|IEA; GO:0005488|binding|IEA; GO:0005634|nucleus|IEA; GO:0005643|nuclear pore|IEA; GO:0005737|cytoplasm|IEA; GO:0008565|protein transporter activity|IEA

ACL00002895

Developmental protein DG1037 related cluster

128

4e-07

44% (32/72)

ACL00002896

C-24(28) sterol reductase, putative related cluster

409

1e-39

76% (69/90)

GO:0016020|membrane|IEA

ACL00002899

F27M3.19; oxidoreductase, 2OG-Fe(II) oxygenase family protein

244

4e-20

35% (62/177)

ACL00002900

unclassified

ACL00002901

COesterase domain containing protein

146

2e-10

23% (24/101)

ACL00002902

unclassified

ACL00002903

T32M21.20; Kelch repeat-containing protein

54

5e-07

32% (13/40)

ACL00002904

unclassified

ACL00002905

SODF

Superoxide dismutase [Fe] related cluster

166

2e-11

57% (30/52)

1.15.1.1

Inorganic ion transport and metabolism

GO:0004784|superoxide dismutase activity|IEA; GO:0006801|superoxide metabolism|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0046872|metal ion binding|IEA

ACL00002906

Multisynthetase complex auxiliary component p43 related cluster

107

3e-41

56% (22/39)

GO:0000049|tRNA binding|IEA; GO:0003723|RNA binding|IEA; GO:0005125|cytokine activity|IEA; GO:0006412|protein biosynthesis|IEA

ACL00002907

unclassified

ACL00002908

unclassified

ACL00002909

unclassified

ACL00002910

EF-1-alpha-related GTP-binding protein related cluster

764

4e-80

49% (151/307)

Translation, ribosomal structure and biogenesis

GO:0005525|GTP binding|IEA; GO:0006412|protein biosynthesis|IEA

ACL00002911

unclassified

ACL00002912

unclassified

ACL00002913

unclassified

ACL00002914

unclassified

ACL00002915

Unassigned protein

ACL00002916

Phosphoethanolamine cytidylyltransferase related cluster

146

3e-09

46% (31/67)

2.7.7.14

Aminophosphonate metabolism Glycerolipid metabolism

GO:0009058|biosynthesis|IEA; GO:0016740|transferase activity|IEA; GO:0016779|nucleotidyltransferase activity|IEA

ACL00002917

Ap2b1

Adapter-related protein complex 2 beta 1 subunit related cluster

199

3e-63

66% (40/60)

Intracellular trafficking, secretion, and vesicular transport

GO:0005215|transporter activity|TAS; GO:0030119|membrane coat adaptor complex|TAS

ACL00002918

multi-domain protein

144

9e-10

24% (32/133)

ACL00002919

Heat shock protein 101 related cluster

629

7e-65

67% (126/188)

GO:0005515|protein binding|IEA; GO:0005524|ATP binding|IEA; GO:0006457|protein folding|IEA; GO:0006986|response to unfolded protein|IEA; GO:0019538|protein metabolism|IEA; GO:0051082|unfolded protein binding|IEA

ACL00002921

Multiubiquitin chain-binding protein related cluster

527

6e-53

49% (113/229)

ACL00002922

multi-domain protein

183

4e-14

19% (40/209)

ACL00002923

unclassified

ACL00002924

SLC25A1

Tricarboxylate transport protein, mitochondrial precursor related cluster

704

2e-73

53% (139/259)

GO:0005215|transporter activity|IEA; GO:0005488|binding|IEA; GO:0005739|mitochondrion|IEA; GO:0005743|mitochondrial inner membrane|IEA; GO:0005743|mitochondrial inner membrane|TAS; GO:0006810|transport|IEA; GO:0006843|mitochondrial citrate transport|TAS; GO:0015137|citrate transporter activity|TAS; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0019866|inner membrane|IEA

ACL00002925

SUCB

Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial precursor related cluster

531

2e-53

74% (102/137)

6.2.1.4

Energy production and conversion

Citrate cycle (TCA cycle) Propanoate metabolism

GO:0003824|catalytic activity|IEA; GO:0004776|succinate-CoA ligase (GDP-forming) activity|IEA; GO:0005739|mitochondrion|IEA; GO:0006099|tricarboxylic acid cycle|IEA; GO:0008152|metabolism|IEA; GO:0016874|ligase activity|IEA

ACL00002926

unclassified

ACL00002927

LCAT

Phosphatidylcholine-sterol acyltransferase precursor related cluster

137

4e-08

36% (31/84)

2.3.1.43

GO:0003824|catalytic activity|IEA; GO:0004607|phosphatidylcholine-sterol O-acyltransferase activity|IEA; GO:0005615|extracellular space|TAS; GO:0006629|lipid metabolism|IEA; GO:0008203|cholesterol metabolism|IEA; GO:0008415|acyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00002928

Fatty acid desaturase related cluster

144

6e-09

32% (29/88)

Lipid transport and metabolism

GO:0006633|fatty acid biosynthesis|IEA; GO:0006636|fatty acid desaturation|IEA; GO:0016020|membrane|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016717|oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water|IEA

ACL00002929

multi-domain protein

238

6e-21

43% (59/135)

ACL00002930

unclassified

ACL00002931

unclassified

ACL00002932

Pafah1b1

Platelet-activating factor acetylhydrolase IB alpha subunit related cluster

163

4e-11

31% (42/135)

3.1.1.47

Glycerolipid metabolism

GO:0000910|cytokinesis|IEA; GO:0005737|cytoplasm|NR; GO:0005856|cytoskeleton|IEA; GO:0006629|lipid metabolism|TAS; GO:0006928|cell motility|TAS; GO:0007067|mitosis|IEA; GO:0007165|signal transduction|TAS; GO:0007399|neurogenesis|IEA; GO:0007399|neurogenesis|TAS

ACL00002933

STATc protein related cluster

664

6e-69

63% (120/188)

GO:0007242|intracellular signaling cascade|IEA

ACL00002935

ACOX1

Acyl-coenzyme A oxidase 1, peroxisomal related cluster

104

6e-12

56% (21/37)

1.3.3.6

Fatty acid metabolism

GO:0003997|acyl-CoA oxidase activity|IEA; GO:0003997|acyl-CoA oxidase activity|TAS; GO:0005739|mitochondrion|IDA; GO:0005777|peroxisome|IEA; GO:0005777|peroxisome|TAS; GO:0006118|electron transport|IEA; GO:0006631|fatty acid metabolism|IEA; GO:0006635|fatty acid beta-oxidation|IEA; GO:0006635|fatty acid beta-oxidation|TAS; GO:0007283|spermatogenesis|IMP; GO:0016491|oxidoreductase activity|IEA

ACL00002936

SLC25A20

Similar to solute carrier family 25 (Carnitine/acylcarnitine translocase), member 20 related cluster

211

4e-45

55% (43/77)

GO:0005215|transporter activity|IEA; GO:0005488|binding|IEA; GO:0005743|mitochondrial inner membrane|IEA; GO:0006810|transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA

ACL00002937

DUS5

Dual specificity protein phosphatase 5 related cluster

147

4e-09

45% (31/68)

3.1.3.16

Signal transduction mechanisms

MAPK signaling pathway

GO:0004721|phosphoprotein phosphatase activity|IEA; GO:0004725|protein tyrosine phosphatase activity|TAS; GO:0005634|nucleus|IEA; GO:0006470|protein amino acid dephosphorylation|IEA; GO:0006470|protein amino acid dephosphorylation|TAS; GO:0008138|protein tyrosine/serine/threonine phosphatase activity|IEA; GO:0016787|hydrolase activity|IEA; GO:0017017|MAP kinase phosphatase activity|IEA

ACL00002938

unclassified

ACL00002939

unclassified

ACL00002940

Ryanodine receptor 2 related cluster

117

8e-06

34% (17/50)

GO:0004872|receptor activity|IEA; GO:0004872|receptor activity|NR; GO:0005216|ion channel activity|IEA; GO:0005219|ryanodine-sensitive calcium-release channel activity|IEA; GO:0005261|cation channel activity|IEA; GO:0005262|calcium channel activity|IEA; GO:0005509|calcium ion binding|IEA; GO:0005516|calmodulin binding|IEA; GO:0005886|plasma membrane|TAS; GO:0005887|integral to plasma membrane|NR; GO:0006811|ion transport|IEA; GO:0006812|cation transport|IEA; GO:0006816|calcium ion transport|IEA; GO:0006816|calcium ion transport|NR; GO:0006874|calcium ion homeostasis|IEA; GO:0006936|muscle contraction|TAS; GO:0007165|signal transduction|NAS; GO:0008016|regulation of heart contraction rate|TAS; GO:0015278|calcium-release channel activity|TAS; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA

ACL00002941

Glutamine synthase related cluster

91

3e-17

76% (16/21)

General function prediction only

GO:0004356|glutamate-ammonia ligase activity|IEA; GO:0009399|nitrogen fixation|IEA; GO:0016874|ligase activity|IEA

ACL00002942

multi-domain protein

136

6e-09

44% (27/61)

ACL00002943

unclassified

ACL00002944

unclassified

ACL00002945

unclassified

ACL00002946

DUF367 domain containing protein

174

1e-13

51% (27/52)

ACL00002947

PTP3

Protein-tyrosine phosphatase 3 related cluster

121

1e-19

50% (28/56)

3.1.3.48

Signal transduction mechanisms

GO:0004721|phosphoprotein phosphatase activity|IEA; GO:0004725|protein tyrosine phosphatase activity|IEA; GO:0006470|protein amino acid dephosphorylation|IEA; GO:0016787|hydrolase activity|IEA

ACL00002948

RAB21

Ras-related protein Rab-21 related cluster

681

9e-71

65% (132/203)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00002949

unclassified

ACL00002950

KADC

Adenylate kinase, chloroplast related cluster

165

1e-10

28% (48/166)

2.7.4.3

Nucleotide transport and metabolism

Purine metabolism

GO:0004017|adenylate kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0009507|chloroplast|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA; GO:0016776|phosphotransferase activity, phosphate group as acceptor|IEA

ACL00002951

unclassified

ACL00002952

Putative acyl-CoA dehydrogenase G6P related cluster

416

2e-40

53% (85/160)

1.3.99.7

Lipid transport and metabolism

Benzoate degradation via CoA ligation Fatty acid metabolism Lysine degradation Tryptophan metabolism

GO:0003995|acyl-CoA dehydrogenase activity|IEA; GO:0006118|electron transport|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00002953

EIF3S9

Eukaryotic translation initiation factor 3 subunit 9 related cluster

752

8e-79

50% (149/294)

GO:0003723|RNA binding|IEA; GO:0003743|translation initiation factor activity|IEA; GO:0003743|translation initiation factor activity|TAS; GO:0005852|eukaryotic translation initiation factor 3 complex|TAS; GO:0006412|protein biosynthesis|IEA; GO:0006413|translational initiation|IEA; GO:0006413|translational initiation|TAS

ACL00002954

GTP-binding protein SAR1B related cluster

513

3e-51

65% (95/145)

General function prediction only

GO:0005525|GTP binding|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0005794|Golgi apparatus|IEA; GO:0006886|intracellular protein transport|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00002955

putative MR-MLE-family protein

201

9e-16

40% (42/104)

ACL00002956

GLSL

Glutaminase, liver isoform, mitochondrial precursor related cluster

215

3e-17

34% (46/134)

3.5.1.2

GO:0004359|glutaminase activity|IEA; GO:0004359|glutaminase activity|TAS; GO:0005739|mitochondrion|IEA; GO:0005739|mitochondrion|TAS; GO:0006520|amino acid metabolism|TAS; GO:0006541|glutamine metabolism|IEA; GO:0016787|hydrolase activity|IEA

ACL00002957

unclassified

ACL00002958

multi-domain protein

148

3e-10

24% (53/213)

ACL00002960

unclassified

ACL00002961

Leucine-rich-repeat protein-like related cluster

165

2e-11

33% (38/112)

Function unknown

ACL00002962

Putative GTP-binding protein DRG related cluster

698

5e-73

72% (124/170)

General function prediction only

GO:0005525|GTP binding|IEA

ACL00002964

Putative mitochondrial carrier protein related cluster

132

7e-07

28% (46/160)

GO:0005488|binding|IEA; GO:0005743|mitochondrial inner membrane|IEA; GO:0006810|transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA

ACL00002965

unclassified

ACL00002966

Small GTP binding protein rab1a, probable related cluster

73

7e-24

37% (17/45)

General function prediction only

GO:0000160|two-component signal transduction system (phosphorelay)|IEA; GO:0003677|DNA binding|IEA; GO:0005525|GTP binding|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00002967

Unassigned protein

ACL00002969

LKHA

Leukotriene A-4 hydrolase related cluster

455

1e-44

49% (92/186)

3.3.2.6

Prostaglandin and leukotriene metabolism

GO:0003824|catalytic activity|IEA; GO:0004179|membrane alanyl aminopeptidase activity|IEA; GO:0004301|epoxide hydrolase activity|TAS; GO:0004463|leukotriene-A4 hydrolase activity|IEA; GO:0004463|leukotriene-A4 hydrolase activity|TAS; GO:0006508|proteolysis and peptidolysis|IEA; GO:0006954|inflammatory response|NAS; GO:0008233|peptidase activity|TAS; GO:0008237|metallopeptidase activity|IEA; GO:0008270|zinc ion binding|IEA; GO:0008270|zinc ion binding|TAS; GO:0016787|hydrolase activity|IEA; GO:0019370|leukotriene biosynthesis|IEA; GO:0019370|leukotriene biosynthesis|TAS

ACL00002970

Putative DNA damage repair protein related cluster

288

3e-25

43% (63/144)

GO:0003676|nucleic acid binding|IEA; GO:0003723|RNA binding|IEA; GO:0005622|intracellular|IEA

ACL00002972

human Ku70 autoantigen homologue

167

9e-12

44% (40/90)

ACL00002973

Adenosine kinase related cluster

194

2e-78

51% (39/76)

2.7.1.20

Carbohydrate transport and metabolism

Purine metabolism

GO:0004001|adenosine kinase activity|IEA; GO:0006166|purine ribonucleoside salvage|IEA; GO:0016301|kinase activity|IEA

ACL00002974

2-oxoglutarate dehydrogenase, E1 subunit related cluster

316

6e-29

70% (58/82)

1.2.4.2

Energy production and conversion

Citrate cycle (TCA cycle) Lysine degradation Tryptophan metabolism

GO:0004591|oxoglutarate dehydrogenase (succinyl-transferring) activity|IEA; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016624|oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor|IEA

ACL00002975

UBP4

Ubiquitin carboxyl-terminal hydrolase 4 related cluster

547

6e-55

47% (112/236)

3.1.2.15

Posttranslational modification, protein turnover, chaperones

GO:0004197|cysteine-type endopeptidase activity|IEA; GO:0004197|cysteine-type endopeptidase activity|TAS; GO:0004221|ubiquitin thiolesterase activity|IEA; GO:0004843|ubiquitin-specific protease activity|TAS; GO:0005634|nucleus|TAS; GO:0005764|lysosome|TAS; GO:0006511|ubiquitin-dependent protein catabolism|IEA; GO:0006512|ubiquitin cycle|IEA; GO:0008151||IEA; GO:0008234|cysteine-type peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00002976

3HIDH

Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial related cluster

220

1e-17

33% (50/148)

1.1.1.31

Lipid transport and metabolism

GO:0005739|mitochondrion|IEA; GO:0006573|valine metabolism|IEA; GO:0008442|3-hydroxyisobutyrate dehydrogenase activity|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00002977

unclassified

ACL00002978

CBS domain containing protein

118

5e-07

38% (19/50)

ACL00002979

VA0D

Vacuolar ATP synthase subunit d related cluster

1258

1e-137

67% (233/346)

3.6.3.14

Energy production and conversion

GO:0006754|ATP biosynthesis|IEA; GO:0015078|hydrogen ion transporter activity|IEA; GO:0015986|ATP synthesis coupled proton transport|IEA; GO:0015992|proton transport|IEA; GO:0016469|proton-transporting two-sector ATPase complex|IEA; GO:0016787|hydrolase activity|IEA; GO:0046933|hydrogen-transporting ATP synthase activity, rotational mechanism|IEA; GO:0046961|hydrogen-transporting ATPase activity, rotational mechanism|IEA

ACL00002982

Unknown EST

133

2e-09

96% (27/28)

ACL00002983

unclassified

ACL00002984

Ras-related protein Rab-32 related cluster

542

1e-54

48% (102/210)

GO:0005525|GTP binding|IEA; GO:0005739|mitochondrion|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00002987

Unassigned protein

117

8e-06

33% (31/93)

ACL00002988

unclassified

ACL00002989

unclassified

ACL00002990

unclassified

ACL00002991

unclassified

ACL00002992

unclassified

ACL00002993

unclassified

ACL00002994

unclassified

ACL00002995

unclassified

ACL00002997

Nsf

N-ethylmaleimide-sensitive factor related cluster

119

1e-45

57% (22/38)

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

ACL00002998

unclassified

ACL00002999

unclassified

ACL00003000

unclassified

ACL00003001

Ribosomal_L27e domain containing protein

105

4e-06

72% (16/22)

ACL00003006

Unknown EST

122

1e-07

53% (21/39)

ACL00003007

SRI

Sorcin related cluster

156

2e-10

34% (36/105)

GO:0005509|calcium ion binding|IEA

ACL00003008

unclassified

ACL00003009

ADP-ribosylation factor 1-like related cluster

225

1e-53

68% (41/60)

GO:0005525|GTP binding|IEA; GO:0005794|Golgi apparatus|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00003010

unclassified

ACL00003011

multi-domain protein

134

7e-09

48% (29/60)

ACL00003012

unclassified

ACL00003014

Similar to Chlorobium tepidum. phosphoenolpyruvate carboxykinase related cluster

741

1e-77

56% (129/228)

Energy production and conversion

GO:0004611|phosphoenolpyruvate carboxykinase activity|IEA; GO:0005525|GTP binding|IEA; GO:0006094|gluconeogenesis|IEA; GO:0016301|kinase activity|IEA

ACL00003015

Rac3

RAS-related protein rac1C related cluster

745

4e-78

73% (139/189)

MAPK signaling pathway Regulation of actin cytoskeleton Toll-like receptor signaling pathway Wnt signaling pathway

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00003017

unclassified

ACL00003019

multi-domain protein

126

9e-08

19% (38/191)

ACL00003020

Prosaposin related cluster

157

1e-09

32% (27/83)

GO:0005764|lysosome|IEA; GO:0006629|lipid metabolism|IEA; GO:0006665|sphingolipid metabolism|IEA; GO:0007585|respiratory gaseous exchange|IEA

ACL00003021

Histone H2A-like protein related cluster

427

2e-41

82% (84/102)

Chromatin structure and dynamics

GO:0000786|nucleosome|IEA; GO:0003677|DNA binding|IEA; GO:0005634|nucleus|IEA; GO:0005694|chromosome|IEA; GO:0006334|nucleosome assembly|IEA; GO:0007001|chromosome organization and biogenesis (sensu Eukaryota)|IEA

ACL00003022

unclassified

ACL00003023

Ras-like protein rasC related cluster

599

3e-61

65% (113/172)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00003025

RNA-binding glycine rich protein related cluster

251

5e-21

57% (46/80)

General function prediction only

GO:0003723|RNA binding|IEA

ACL00003027

Epithelial protein lost in neoplasm related cluster

157

2e-10

50% (27/53)

GO:0005856|cytoskeleton|IEA; GO:0008270|zinc ion binding|IEA; GO:0015629|actin cytoskeleton|IDA

ACL00003028

SAHH

Adenosylhomocysteinase related cluster

662

1e-68

76% (123/161)

3.3.1.1

Methionine metabolism Selenoamino acid metabolism

GO:0004013|adenosylhomocysteinase activity|IEA; GO:0006730|one-carbon compound metabolism|IEA; GO:0016787|hydrolase activity|IEA

ACL00003029

FLJ32642

FLJ32642; hepatocellular carcinoma related protein 1

168

3e-11

29% (47/158)

ACL00003035

Ostf1

Osteoclast stimulating factor related cluster

160

8e-11

37% (37/98)

ACL00003038

GGPS1

Geranylgeranyl pyrophosphate synthase related cluster

619

1e-63

57% (113/196)

2.5.1.1 2.5.1.10 2.5.1.29

Coenzyme transport and metabolism

Biosynthesis of steroids Terpenoid biosynthesis

GO:0008299|isoprenoid biosynthesis|IEA

ACL00003039

Ubiquitin C-terminal hydrolase-like protein related cluster

409

1e-39

51% (74/144)

GO:0004221|ubiquitin thiolesterase activity|IEA; GO:0005622|intracellular|IEA; GO:0006511|ubiquitin-dependent protein catabolism|IEA; GO:0016787|hydrolase activity|IEA

ACL00003040

unclassified

ACL00003042

HYP2

Eukaryotic translation initiation factor 5A related cluster

269

6e-23

39% (54/137)

Translation, ribosomal structure and biogenesis

GO:0003743|translation initiation factor activity|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006413|translational initiation|IEA

ACL00003044

zgc:55831

40S ribosomal protein SA related cluster

724

2e-75

59% (143/242)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0015935|small ribosomal subunit|IEA

ACL00003046

unclassified

ACL00003047

MMAB

Cob(I)alamin adenosyltransferase, mitochondrial precursor related cluster

353

4e-33

53% (82/153)

2.5.1.17

GO:0005739|mitochondrion|IEA; GO:0008817|cob(I)yrinic acid a,c-diamide adenosyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00003048

Ras-related protein Rab4 related cluster

714

7e-75

86% (137/159)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00003049

Rpl19

Ribosomal protein L19 related cluster

525

1e-52

64% (100/154)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00003050

multi-domain protein

151

1e-10

50% (32/63)

ACL00003051

Unknown EST

123

2e-07

63% (21/33)

ACL00003052

multi-domain protein

114

2e-06

32% (40/123)

ACL00003053

unclassified

ACL00003054

unclassified

ACL00003055

50S ribosomal protein L13 related cluster

98

8e-28

42% (19/45)

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00003056

Spnb3

Beta-G spectrin related cluster

344

1e-31

41% (79/192)

GO:0003779|actin binding|IEA

ACL00003057

GTP-binding protein YPTC5 related cluster

103

6e-43

50% (25/50)

General function prediction only

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00003058

Neurula-specific ferrodoxin reductase-like protein related cluster

300

5e-27

46% (65/140)

GO:0006118|electron transport|IEA; GO:0015036|disulfide oxidoreductase activity|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00003059

Dihydrolipoamide dehydrogenase precursor related cluster

155

8e-41

62% (31/50)

Energy production and conversion

GO:0004148|dihydrolipoyl dehydrogenase activity|IEA; GO:0005737|cytoplasm|IEA; GO:0006118|electron transport|IEA; GO:0015036|disulfide oxidoreductase activity|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0050660|FAD binding|IEA

ACL00003060

MxaD protein precursor related cluster

150

3e-09

32% (45/140)

ACL00003061

S-adenosyl methionine synthetase related cluster

383

2e-78

62% (70/112)

Coenzyme transport and metabolism

Methionine metabolism Selenoamino acid metabolism

GO:0000287|magnesium ion binding|IEA; GO:0004478|methionine adenosyltransferase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006730|one-carbon compound metabolism|IEA; GO:0016740|transferase activity|IEA

ACL00003063

DUF566 domain containing protein

114

1e-06

20% (30/149)

ACL00003065

Ser/Thr protein phosphatase related cluster

720

2e-75

62% (125/199)

3.1.3.16

Signal transduction mechanisms

GO:0016787|hydrolase activity|IEA

ACL00003068

POLYUBIQUITIN UBC related cluster

2017

0.0

95% (403/420)

ACL00003070

Podocalyxin domain containing protein

116

1e-06

23% (30/130)

ACL00003072

unclassified

ACL00003074

wos2

wos2; cell cycle regulator p21 protein, Wos2p

131

3e-07

45% (27/60)

ACL00003075

CATA

Catalase related cluster

1097

1e-118

64% (209/323)

1.11.1.6

Inorganic ion transport and metabolism

GO:0004096|catalase activity|IEA; GO:0004601|peroxidase activity|IEA; GO:0005777|peroxisome|IEA; GO:0006118|electron transport|IEA; GO:0006979|response to oxidative stress|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00003078

RNA-binding glycine rich protein related cluster

272

2e-23

66% (52/78)

General function prediction only

GO:0003723|RNA binding|IEA

ACL00003079

AGR107Cp

AGR107Cp; syntenic homolog of Saccharomyces cerevisiae YDR099W (BMH2) and YER177W (BMH1)

182

3e-67

65% (40/61)

ACL00003081

Unassigned protein

170

2e-11

33% (61/184)

ACL00003082

Eef1b2

Elongation factor-1D related cluster

293

1e-25

62% (56/89)

Translation, ribosomal structure and biogenesis

GO:0003746|translation elongation factor activity|IEA; GO:0005853|eukaryotic translation elongation factor 1 complex|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006414|translational elongation|IEA

ACL00003085

Putative nucleoside diphosphate kinase related cluster

475

1e-46

58% (87/149)

2.7.4.6

Nucleotide transport and metabolism

Purine metabolism Pyrimidine metabolism

GO:0004550|nucleoside-diphosphate kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006183|GTP biosynthesis|IEA; GO:0006228|UTP biosynthesis|IEA; GO:0006241|CTP biosynthesis|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00003089

act-4

Actin, cytoplasmic 2 related cluster

1257

1e-137

96% (241/249)

Cytoskeleton

GO:0005200|structural constituent of cytoskeleton|NR

ACL00003090

act-4

Actin, cytoplasmic 2 related cluster

391

0.0

97% (72/74)

Cytoskeleton

GO:0005200|structural constituent of cytoskeleton|NR

ACL00003101

unclassified

ACL00003102

unclassified

ACL00003103

multi-domain protein

109

8e-06

22% (37/161)

ACL00003104

Protein arginine N-methyltransferase 3-like protein related cluster

123

2e-06

62% (22/35)

GO:0003676|nucleic acid binding|IEA; GO:0005634|nucleus|IEA; GO:0008168|methyltransferase activity|IEA; GO:0008270|zinc ion binding|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00003105

unclassified

ACL00003106

unclassified

ACL00003107

Unassigned protein

179

2e-12

29% (50/171)

ACL00003108

A-type cyclin related cluster

140

2e-08

32% (37/114)

GO:0000074|regulation of cell cycle|IEA; GO:0000910|cytokinesis|IEA; GO:0005634|nucleus|IEA; GO:0007049|cell cycle|IEA

ACL00003109

multi-domain protein

114

1e-06

49% (32/65)

ACL00003111

unclassified

ACL00003112

Pyruvate kinase related cluster

616

5e-63

50% (133/261)

Carbohydrate transport and metabolism

Carbon fixation Glycolysis / Gluconeogenesis Purine metabolism Pyruvate metabolism

GO:0000287|magnesium ion binding|IEA; GO:0004743|pyruvate kinase activity|IEA; GO:0006096|glycolysis|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00003113

[J] COG0009 Putative translation factor (SUA5)

114

7e-06

59% (22/37)

Translation, ribosomal structure and biogenesis

ACL00003114

unclassified

ACL00003115

SERC

Phosphoserine aminotransferase related cluster

277

2e-24

45% (56/122)

2.6.1.52

Glycine, serine and threonine metabolism Vitamin B6 metabolism

GO:0004648|phosphoserine transaminase activity|IEA; GO:0006564|L-serine biosynthesis|IEA; GO:0008152|metabolism|IEA; GO:0008483|transaminase activity|IEA; GO:0008615|pyridoxine biosynthesis|IEA; GO:0016740|transferase activity|IEA

ACL00003116

Similar to Homo sapiens (Human). Sec13-like protein related cluster

116

6e-35

75% (21/28)

ACL00003117

Rhodanese family protein related cluster

181

3e-13

51% (41/80)

2.8.1.1

Inorganic ion transport and metabolism

GO:0004792|thiosulfate sulfurtransferase activity|IEA; GO:0008272|sulfate transport|IEA; GO:0016740|transferase activity|IEA

ACL00003118

unclassified

ACL00003119

unclassified

ACL00003121

unclassified

ACL00003122

unclassified

ACL00003123

unclassified

ACL00003124

PH domain containing protein

155

4e-11

30% (30/99)

ACL00003125

unclassified

ACL00003126

unclassified

ACL00003127

Phosphoethanolamine cytidylyltransferase related cluster

226

4e-18

37% (52/138)

2.7.7.14

Aminophosphonate metabolism Glycerolipid metabolism

GO:0009058|biosynthesis|IEA; GO:0016740|transferase activity|IEA; GO:0016779|nucleotidyltransferase activity|IEA

ACL00003128

F11F12.15; membrane trafficking VPS53 family protein

394

1e-37

43% (77/178)

ACL00003129

unclassified

ACL00003130

Similar to vesicle transport protein related cluster

148

2e-09

37% (29/78)

GO:0006886|intracellular protein transport|IEA; GO:0016021|integral to membrane|IEA

ACL00003131

unclassified

ACL00003132

GNS1/SUR4 family protein related cluster

244

1e-20

40% (52/128)

GO:0016021|integral to membrane|IEA

ACL00003133

Small GTP-binding protein related cluster

94

2e-16

55% (15/27)

General function prediction only

GO:0000160|two-component signal transduction system (phosphorelay)|IEA; GO:0003677|DNA binding|IEA; GO:0005525|GTP binding|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00003134

T16K5.80; pentatricopeptide (PPR) repeat-containing protein

126

1e-06

32% (35/107)

ACL00003135

unclassified

ACL00003136

Ribonuclease II related cluster

204

1e-15

31% (46/148)

3.1.13.1

Transcription

GO:0003723|RNA binding|IEA; GO:0004540|ribonuclease activity|IEA

ACL00003138

unclassified

ACL00003139

Unassigned protein

143

4e-09

35% (30/85)

ACL00003140

unclassified

ACL00003141

unclassified

ACL00003142

Acetyltransferase, GNAT family related cluster

158

3e-31

36% (44/121)

Translation, ribosomal structure and biogenesis

GO:0008080|N-acetyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00003143

unclassified

ACL00003144

unclassified

ACL00003145

Clcn7

Chloride channel protein 7 related cluster

248

5e-21

43% (57/132)

GO:0005216|ion channel activity|IEA; GO:0005244|voltage-gated ion channel activity|IEA; GO:0005247|voltage-gated chloride channel activity|IEA; GO:0005254|chloride channel activity|TAS; GO:0005624|membrane fraction|NR; GO:0005887|integral to plasma membrane|NR; GO:0006810|transport|TAS; GO:0006811|ion transport|IEA; GO:0006821|chloride transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA

ACL00003146

Unassigned protein

ACL00003147

Unassigned protein

119

3e-06

37% (25/66)

ACL00003148

unclassified

ACL00003149

PNKP

DNA 5'-kinase/3'-phosphatase related cluster

139

9e-23

50% (26/51)

Amino acid transport and metabolism

GO:0000718|nucleotide-excision repair, DNA damage removal|NAS; GO:0003684|damaged DNA binding|NAS; GO:0003690|double-stranded DNA binding|TAS; GO:0005634|nucleus|IDA; GO:0009314|response to radiation|NAS; GO:0016311|dephosphorylation|IDA; GO:0017076|purine nucleotide binding|NAS; GO:0019201|nucleotide kinase activity|IDA; GO:0042769|DNA damage response, perception of DNA damage|NAS; GO:0046403|polynucleotide 3'-phosphatase activity|IDA; GO:0046404|polynucleotide 5'-hydroxyl-kinase activity|IDA; GO:0046939|nucleotide phosphorylation|IDA

ACL00003150

unclassified

ACL00003151

rab5al

Similar to RAB5A, member RAS oncogene family related cluster

623

6e-64

65% (131/201)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00003152

Heat-shock protein related cluster

149

2e-23

47% (33/69)

GO:0005524|ATP binding|IEA

ACL00003153

Unknown EST

124

5e-08

47% (21/44)

ACL00003155

unclassified

ACL00003156

T20O10.100; NPL4 family protein

236

2e-19

37% (59/159)

ACL00003157

Unassigned protein

116

1e-05

40% (29/72)

ACL00003158

ALG5

Dolichyl-phosphate beta-glucosyltransferase related cluster

219

1e-17

60% (39/64)

2.4.1.117

GO:0004576|oligosaccharyl transferase activity|TAS; GO:0004581|dolichyl-phosphate beta-glucosyltransferase activity|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0006486|protein amino acid glycosylation|TAS; GO:0016021|integral to membrane|IEA; GO:0016740|transferase activity|IEA; GO:0016757|transferase activity, transferring glycosyl groups|IEA

ACL00003159

ER lumen protein retaining receptor related cluster

544

5e-55

52% (103/196)

Intracellular trafficking, secretion, and vesicular transport

GO:0004872|receptor activity|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0015031|protein transport|IEA; GO:0016021|integral to membrane|IEA

ACL00003160

Unknown EST

80

7e-10

42% (14/33)

ACL00003161

TDH

L-threonine 3-dehydrogenase related cluster

232

8e-19

36% (51/139)

1.1.1.103

Glycine, serine and threonine metabolism

GO:0004024|alcohol dehydrogenase activity, zinc-dependent|IEA; GO:0006567|threonine catabolism|IEA; GO:0008270|zinc ion binding|IEA; GO:0008743|L-threonine 3-dehydrogenase activity|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00003162

unclassified

ACL00003163

unclassified

ACL00003164

unclassified

ACL00003165

unclassified

ACL00003166

Protein kinase related cluster

292

4e-26

52% (61/116)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0004713|protein-tyrosine kinase activity|IEA; GO:0004871|signal transducer activity|IEA; GO:0005524|ATP binding|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0007165|signal transduction|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00003167

unclassified

ACL00003168

Thiosulfate sulfurtransferase related cluster

295

3e-26

35% (74/206)

Inorganic ion transport and metabolism

GO:0004792|thiosulfate sulfurtransferase activity|IEA; GO:0008272|sulfate transport|IEA; GO:0016740|transferase activity|IEA

ACL00003169

unclassified

ACL00003171

Similar to Homo sapiens (Human). MUM2 protein related cluster

87

1e-14

31% (19/61)

GO:0005801|Golgi cis-face|IEA; GO:0006888|ER to Golgi transport|IEA

ACL00003172

SH2 domain containing protein

86

1e-04

36% (18/49)

ACL00003173

Putative transcription factor II related cluster

299

1e-26

55% (58/104)

Transcription

Basal transcription factors

GO:0003700|transcription factor activity|IEA; GO:0005634|nucleus|IEA; GO:0006352|transcription initiation|IEA

ACL00003174

unclassified

ACL00003175

Putative flavin-containing monooxygenase related cluster

170

9e-12

29% (47/157)

GO:0004497|monooxygenase activity|IEA; GO:0004499|dimethylaniline monooxygenase (N-oxide-forming) activity|IEA; GO:0005792|microsome|IEA; GO:0006118|electron transport|IEA; GO:0015036|disulfide oxidoreductase activity|IEA

ACL00003176

unclassified

ACL00003177

Protein kinase related cluster

130

3e-07

38% (32/84)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0004713|protein-tyrosine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00003178

Ctr domain containing protein

216

6e-18

26% (42/159)

ACL00003179

unclassified

ACL00003180

Unassigned protein

154

8e-10

32% (51/157)

ACL00003181

unclassified

ACL00003182

Transcriptional adapter 2 related cluster

135

6e-08

40% (23/57)

GO:0000124|SAGA complex|IDA; GO:0003677|DNA binding|IEA; GO:0003713|transcription coactivator activity|TAS; GO:0005634|nucleus|IEA; GO:0005671|Ada2/Gcn5/Ada3 transcription activator complex|IPI; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0008270|zinc ion binding|IEA; GO:0016568|chromatin modification|TAS; GO:0016573|histone acetylation|TAS; GO:0046695|SLIK (SAGA-like) complex|IPI

ACL00003183

unclassified

ACL00003184

Putative N-terminal acetyltransferase related cluster

183

2e-13

39% (38/97)

GO:0005488|binding|IEA; GO:0016740|transferase activity|IEA

ACL00003185

Unassigned protein

164

6e-11

37% (41/109)

ACL00003186

Myosin heavy chain kinase C related cluster

270

3e-23

41% (65/156)

GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA

ACL00003187

Protamine_P1 domain containing protein

109

6e-06

43% (24/55)

ACL00003188

Probable glutathione S-transferase related cluster

286

2e-25

66% (49/74)

Posttranslational modification, protein turnover, chaperones

GO:0016740|transferase activity|IEA

ACL00003189

Bms1l

Ribosome biogenesis protein BMS1 homolog related cluster

297

1e-26

43% (65/149)

Translation, ribosomal structure and biogenesis

GO:0005524|ATP binding|IEA; GO:0005634|nucleus|IEA; GO:0007046|ribosome biogenesis|IEA

ACL00003190

unclassified

ACL00003191

hutI

Imidazolonepropionase related cluster

332

2e-30

42% (73/170)

3.5.2.7

Secondary metabolites biosynthesis, transport and catabolism

Histidine metabolism

GO:0005737|cytoplasm|IEA; GO:0016787|hydrolase activity|IEA; GO:0016812|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides|IEA; GO:0019556|histidine catabolism to glutamate and formamide|IEA

ACL00003192

unclassified

ACL00003193

Possible 3-ketoacyl-CoA thiolase related cluster

343

5e-32

61% (74/121)

2.3.1.16

Lipid transport and metabolism

Benzoate degradation via hydroxylation Bile acid biosynthesis Fatty acid biosynthesis (path 2) Fatty acid metabolism Valine, leucine and isoleucine degradation

ACL00003194

unclassified

ACL00003196

unclassified

ACL00003197

unclassified

ACL00003198

Predicted dinucleotide-utilizing enzyme related cluster

151

2e-09

30% (47/154)

General function prediction only

ACL00003199

unclassified

ACL00003200

unclassified

ACL00003201

Similarity to GTPase activating protein related cluster

220

9e-18

50% (37/74)

General function prediction only

ACL00003202

3-beta-hydroxysteroid dehydrogenase related cluster

275

4e-24

48% (54/111)

GO:0003854|3-beta-hydroxy-delta5-steroid dehydrogenase activity|IEA; GO:0006694|steroid biosynthesis|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00003203

CSL4

3'-5' exoribonuclease CSL4 homolog related cluster

282

1e-24

55% (59/106)

3.1.13.-

GO:0000178|exosome (RNase complex)|IEA; GO:0000178|exosome (RNase complex)|NAS; GO:0003723|RNA binding|IEA; GO:0003723|RNA binding|NAS; GO:0004518|nuclease activity|IEA; GO:0004527|exonuclease activity|IEA; GO:0005515|protein binding|IPI; GO:0005634|nucleus|IEA; GO:0005730|nucleolus|IDA; GO:0006364|rRNA processing|IEA; GO:0016787|hydrolase activity|IEA

ACL00003204

unclassified

ACL00003205

Similar to programmed cell death 2 related cluster

166

2e-11

36% (38/105)

GO:0005737|cytoplasm|IEA; GO:0006915|apoptosis|IEA

ACL00003206

unclassified

ACL00003207

Putative GTP-binding protein related cluster

481

1e-47

53% (97/182)

General function prediction only

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00003208

unclassified

ACL00003209

Keratin_B2 domain containing protein

110

7e-06

23% (33/140)

ACL00003210

TXNL

Thioredoxin-like protein 1 related cluster

649

6e-67

50% (127/252)

GO:0005489|electron transporter activity|IEA; GO:0005737|cytoplasm|TAS; GO:0006118|electron transport|IEA; GO:0006118|electron transport|TAS; GO:0006915|apoptosis|TAS; GO:0007165|signal transduction|TAS; GO:0030508|thiol-disulfide exchange intermediate activity|TAS

ACL00003211

unclassified

ACL00003212

Similar to Dictyostelium discoideum (Slime mold). GrfA related cluster

184

2e-13

36% (41/112)

ACL00003213

unclassified

ACL00003214

unclassified

ACL00003215

Similar to Rho GTPase activating protein 12 related cluster

148

4e-09

28% (38/133)

ACL00003216

unclassified

ACL00003217

unclassified

ACL00003218

RhoGEF domain containing protein

99

6e-06

53% (16/30)

ACL00003219

fabG2

Dehydrogenases with different specificities related cluster

179

4e-35

61% (34/55)

1.-.-.-

GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00003220

unclassified

ACL00003221

unclassified

ACL00003222

Unassigned protein

ACL00003223

Actin bundling protein related cluster

143

2e-08

31% (45/145)

ACL00003224

OGFRL1

Similar to opioid growth factor receptor related cluster

140

2e-08

46% (29/62)

GO:0004872|receptor activity|IEA; GO:0008151||IEA; GO:0016020|membrane|IEA

ACL00003225

Unknown EST

123

5e-08

40% (23/57)

ACL00003226

zupT

zupT; zinc transporter

128

3e-07

41% (28/68)

Inorganic ion transport and metabolism

ACL00003227

unclassified

ACL00003228

Putative translation initiation factor 3 related cluster

474

3e-47

61% (81/132)

GO:0003743|translation initiation factor activity|IEA; GO:0005488|binding|IEA

ACL00003229

unclassified

ACL00003230

T12H3.8; SNF7 family protein

358

2e-33

51% (76/149)

ACL00003232

unclassified

ACL00003233

rplO

Probable 50S ribosomal protein L15 related cluster

61

2e-15

48% (12/25)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0015934|large ribosomal subunit|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00003234

unclassified

ACL00003235

GGH

Gamma-glutamyl hydrolase precursor related cluster

270

2e-23

32% (50/154)

3.4.19.9

GO:0005764|lysosome|IEA; GO:0008238|exopeptidase activity|TAS; GO:0008464|gamma-glutamyl hydrolase activity|IEA; GO:0008464|gamma-glutamyl hydrolase activity|TAS; GO:0016787|hydrolase activity|IEA

ACL00003236

unclassified

ACL00003238

unclassified

ACL00003239

NUIM

NADH-ubiquinone oxidoreductase 23 kDa subunit, mitochondrial precursor related cluster

200

2e-15

45% (43/95)

1.6.5.3

Energy production and conversion

Oxidative phosphorylation

GO:0003954|NADH dehydrogenase activity|IEA; GO:0005489|electron transporter activity|IEA; GO:0005506|iron ion binding|IEA; GO:0005739|mitochondrion|IEA; GO:0006118|electron transport|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016651|oxidoreductase activity, acting on NADH or NADPH|IEA

ACL00003240

unclassified

ACL00003241

unclassified

ACL00003242

unclassified

ACL00003243

Nodulin 21-related protein related cluster

350

3e-32

38% (87/224)

ACL00003244

leucine aminopeptidase

144

4e-09

41% (35/85)

ACL00003245

unclassified

ACL00003246

Putative flavin-containing monoamine oxidase aofH related cluster

211

2e-16

30% (53/174)

Amino acid transport and metabolism

ACL00003247

DUF788 domain containing protein

318

4e-30

40% (57/141)

ACL00003248

unclassified

ACL00003249

unclassified

ACL00003250

Unassigned protein

ACL00003251

unclassified

ACL00003252

Tceb1

Transcription elongation factor B polypeptide 1 related cluster

285

3e-25

61% (57/93)

GO:0003711|transcriptional elongation regulator activity|NR; GO:0005515|protein binding|TAS; GO:0005634|nucleus|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006357|regulation of transcription from Pol II promoter|TAS; GO:0006512|ubiquitin cycle|IEA

ACL00003253

unclassified

ACL00003254

HEC protein, possible related cluster

233

3e-19

37% (43/114)

ACL00003255

WD-40 repeat protein related cluster

143

7e-09

38% (37/97)

General function prediction only

GO:0003677|DNA binding|IEA; GO:0003700|transcription factor activity|IEA; GO:0005524|ATP binding|IEA; GO:0005622|intracellular|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006915|apoptosis|IEA; GO:0006952|defense response|IEA; GO:0042829|defense response to pathogen|IEA

ACL00003256

Short chain dehydrogenase related cluster

182

2e-13

58% (33/56)

GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00003258

Ubiquinone/menaquinone biosynthesis methyltransferase-like related cluster

421

1e-40

52% (84/160)

2.1.1.-

Coenzyme transport and metabolism

Ubiquinone biosynthesis

GO:0008168|methyltransferase activity|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA; GO:0009108|coenzyme biosynthesis|IEA; GO:0016740|transferase activity|IEA

ACL00003259

CLN8

CLN8; ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)

157

3e-10

32% (48/150)

ACL00003260

unclassified

ACL00003261

unclassified

ACL00003262

TyrKc domain containing protein

79

9e-05

63% (14/22)

ACL00003263

unclassified

ACL00003264

TT_ORF1 domain containing protein

114

1e-06

38% (18/47)

ACL00003265

unclassified

ACL00003266

Putative serine/threonine protein kinase related cluster

119

5e-06

65% (23/35)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00003267

Related to TOM1 protein related cluster

354

3e-33

56% (66/116)

GO:0004842|ubiquitin-protein ligase activity|IEA; GO:0005622|intracellular|IEA; GO:0005634|nucleus|IEA; GO:0005737|cytoplasm|IEA; GO:0006397|mRNA processing|IEA; GO:0006406|mRNA-nucleus export|IEA; GO:0006464|protein modification|IEA; GO:0006512|ubiquitin cycle|IEA; GO:0006810|transport|IEA; GO:0016874|ligase activity|IEA; GO:0051028|mRNA transport|IEA

ACL00003268

unclassified

ACL00003269

RNA helicase related cluster

345

1e-90

68% (69/101)

GO:0003676|nucleic acid binding|IEA; GO:0004386|helicase activity|IEA; GO:0005524|ATP binding|IEA; GO:0008026|ATP-dependent helicase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00003270

Ap3m1

Clathrin-adaptor medium chain apm 3 related cluster

408

8e-98

37% (85/228)

GO:0006886|intracellular protein transport|IEA; GO:0030125|clathrin vesicle coat|IEA

ACL00003271

PMA1

Probable plasma membrane ATPase related cluster

507

2e-50

50% (110/219)

3.6.3.6

Inorganic ion transport and metabolism

GO:0000287|magnesium ion binding|IEA; GO:0003824|catalytic activity|IEA; GO:0005524|ATP binding|IEA; GO:0006812|cation transport|IEA; GO:0008152|metabolism|IEA; GO:0008553|hydrogen-exporting ATPase activity, phosphorylative mechanism|IEA; GO:0015078|hydrogen ion transporter activity|IEA; GO:0015662|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|IEA; GO:0015992|proton transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016787|hydrolase activity|IEA; GO:0016820|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|IEA; GO:0016887|ATPase activity|IEA

ACL00003272

Cspg6

Cspg6; chondroitin sulfate proteoglycan 6

191

1e-14

29% (41/137)

ACL00003273

unclassified

ACL00003274

unclassified

ACL00003275

Unassigned protein

ACL00003276

unclassified

ACL00003277

NIPSNAP3B

NipSnap protein related cluster

160

2e-10

22% (35/156)

ACL00003278

unclassified

ACL00003279

Unknown EST

122

8e-07

34% (21/61)

ACL00003281

HMCS

Hydroxymethylglutaryl-CoA synthase, cytoplasmic related cluster

649

3e-67

65% (119/183)

2.3.3.10

Lipid transport and metabolism

Butanoate metabolism Synthesis and degradation of ketone bodies Valine, leucine and isoleucine degradation

GO:0004421|hydroxymethylglutaryl-CoA synthase activity|IEA; GO:0006084|acetyl-CoA metabolism|IEA; GO:0006695|cholesterol biosynthesis|IEA; GO:0016740|transferase activity|IEA

ACL00003282

unclassified

ACL00003283

Mitochondrial chaperone BCS1 related cluster

128

4e-07

30% (39/130)

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0005739|mitochondrion|IEA; GO:0005750|respiratory chain complex III (sensu Eukaryota)|TAS; GO:0006457|protein folding|IEA; GO:0006461|protein complex assembly|TAS; GO:0015980|energy derivation by oxidation of organic compounds|TAS; GO:0016021|integral to membrane|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA; GO:0051082|unfolded protein binding|IEA

ACL00003284

Zinc finger transcription factor ZFP30 related cluster

155

3e-10

34% (32/94)

ACL00003285

unclassified

ACL00003286

unclassified

ACL00003287

Eif5

Eukaryotic translation initiation factor 5 related cluster

201

6e-15

24% (73/299)

Translation, ribosomal structure and biogenesis

GO:0003743|translation initiation factor activity|IEA; GO:0003743|translation initiation factor activity|NAS; GO:0003924|GTPase activity|TAS; GO:0005525|GTP binding|IEA; GO:0005737|cytoplasm|TAS; GO:0005829|cytosol|NAS; GO:0006412|protein biosynthesis|IEA; GO:0006413|translational initiation|IEA; GO:0006413|translational initiation|NAS; GO:0006446|regulation of translational initiation|IEA; GO:0006446|regulation of translational initiation|TAS; GO:0008135|translation factor activity, nucleic acid binding|TAS

ACL00003288

Unassigned protein

125

9e-07

40% (26/65)

ACL00003289

Putative RNA-binding protein related cluster

262

1e-22

45% (46/102)

GO:0003676|nucleic acid binding|IEA; GO:0003723|RNA binding|IEA

ACL00003290

unclassified

ACL00003291

unclassified

ACL00003292

Nucleotide exchange factor RasGEF M related cluster

259

3e-22

47% (49/104)

GO:0005085|guanyl-nucleotide exchange factor activity|IEA; GO:0007242|intracellular signaling cascade|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00003293

unclassified

ACL00003294

Neurofibromin related cluster

179

8e-13

29% (52/179)

GO:0005096|GTPase activator activity|IEA

ACL00003295

unclassified

ACL00003296

unclassified

ACL00003297

MSOX

Monomeric sarcosine oxidase related cluster

106

7e-26

35% (22/62)

1.5.3.1

Amino acid transport and metabolism

Glycine, serine and threonine metabolism

GO:0006118|electron transport|IEA; GO:0008115|sarcosine oxidase activity|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0046653|tetrahydrofolate metabolism|IEA

ACL00003298

UBC2

Ubiquitin-conjugating enzyme E2-17 kDa 2 related cluster

532

7e-54

73% (95/129)

6.3.2.19

Posttranslational modification, protein turnover, chaperones

GO:0004840|ubiquitin conjugating enzyme activity|IEA; GO:0004842|ubiquitin-protein ligase activity|IEA; GO:0006464|protein modification|IEA; GO:0006512|ubiquitin cycle|IEA; GO:0016874|ligase activity|IEA

ACL00003300

Putative U3 small nucleolar ribonucleoprotein protein related cluster

591

2e-60

47% (102/214)

GO:0019013|viral nucleocapsid|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00003301

Nucleotide exchange factor RasGEF D related cluster

254

2e-21

34% (48/139)

GO:0005085|guanyl-nucleotide exchange factor activity|IEA; GO:0007242|intracellular signaling cascade|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00003302

Insulinase, putative related cluster

130

2e-07

23% (40/168)

General function prediction only

ACL00003303

por

Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit related cluster

309

4e-28

51% (64/125)

1.-.-.-

Energy production and conversion

GO:0005489|electron transporter activity|IEA; GO:0005506|iron ion binding|IEA; GO:0006118|electron transport|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00003305

Protein tipD related cluster

284

9e-25

34% (69/199)

ACL00003306

Thiol methyltransferase 1 related cluster

205

8e-16

40% (41/102)

GO:0005737|cytoplasm|IEA; GO:0008119|thiopurine S-methyltransferase activity|IEA; GO:0008152|metabolism|IEA; GO:0008168|methyltransferase activity|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00003307

unclassified

ACL00003308

unclassified

ACL00003309

unclassified

ACL00003310

Chaperonin containing TCP-1 zeta subunit related cluster

117

8e-56

52% (22/42)

Posttranslational modification, protein turnover, chaperones

GO:0005524|ATP binding|IEA; GO:0006457|protein folding|IEA; GO:0051082|unfolded protein binding|IEA

ACL00003311

5NTC

Cytosolic purine 5'-nucleotidase related cluster

305

2e-27

38% (65/167)

3.1.3.5

GO:0003824|catalytic activity|IEA; GO:0005829|cytosol|NR; GO:0008253|5'-nucleotidase activity|IEA; GO:0008253|5'-nucleotidase activity|TAS; GO:0016787|hydrolase activity|IEA

ACL00003312

L-allo-threonine aldolase, putative related cluster

330

2e-30

53% (66/124)

4.1.2.5

Amino acid transport and metabolism

Glycine, serine and threonine metabolism

GO:0006520|amino acid metabolism|IEA; GO:0009072|aromatic amino acid family metabolism|IEA; GO:0016829|lyase activity|IEA; GO:0016830|carbon-carbon lyase activity|IEA

ACL00003313

Extracellular signal-regulated kinase 2 related cluster

248

5e-21

81% (45/55)

2.7.1.37

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00003314

unclassified

ACL00003315

ODP2

Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial precursor related cluster

311

4e-28

57% (58/101)

2.3.1.12

Energy production and conversion

GO:0004742|dihydrolipoyllysine-residue acetyltransferase activity|IDA; GO:0004742|dihydrolipoyllysine-residue acetyltransferase activity|IEA; GO:0005515|protein binding|IEA; GO:0005739|mitochondrion|IDA; GO:0005739|mitochondrion|IEA; GO:0005967|pyruvate dehydrogenase complex (sensu Eukaryota)|TAS; GO:0006090|pyruvate metabolism|TAS; GO:0006096|glycolysis|IEA; GO:0008152|metabolism|IEA; GO:0008415|acyltransferase activity|IEA; GO:0016740|transferase activity|IEA; GO:0045254|pyruvate dehydrogenase complex|IEA

ACL00003316

unclassified

ACL00003317

unclassified

ACL00003318

TAP42 domain containing protein

239

9e-21

23% (58/245)

ACL00003319

Unassigned protein

330

4e-30

40% (73/180)

ACL00003320

Cytohesin 4 related cluster

128

4e-07

39% (21/53)

GO:0005086|ARF guanyl-nucleotide exchange factor activity|TAS

ACL00003321

Putative cytochrome P450 monooxygenase protein related cluster

121

3e-06

38% (23/59)

1.14.-.-

Secondary metabolites biosynthesis, transport and catabolism

Ascorbate and aldarate metabolism Fluorene degradation Limonene and pinene degradation Stilbene, coumarine and lignin biosynthesis gamma-Hexachlorocyclohexane degradation

GO:0004497|monooxygenase activity|IEA; GO:0006118|electron transport|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00003322

Cycloartenol synthase related cluster

428

7e-42

61% (71/116)

GO:0003824|catalytic activity|IEA; GO:0008152|metabolism|IEA; GO:0016829|lyase activity|IEA

ACL00003323

CG2139

Calcium-binding mitochondrial carrier Aralar1 related cluster

141

4e-08

34% (39/113)

GO:0005488|binding|IEA; GO:0005509|calcium ion binding|IEA; GO:0005739|mitochondrion|IEA; GO:0005743|mitochondrial inner membrane|IEA; GO:0006810|transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0019866|inner membrane|IEA

ACL00003324

FBOX domain containing protein

94

1e-05

36% (15/41)

ACL00003325

SYTC

Threonyl-tRNA synthetase, cytoplasmic related cluster

119

3e-44

92% (23/25)

6.1.1.3

Translation, ribosomal structure and biogenesis

GO:0004812|tRNA ligase activity|IEA; GO:0004829|threonine-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0005737|cytoplasm|IMP; GO:0005739|mitochondrion|IDA; GO:0006412|protein biosynthesis|IEA; GO:0006412|protein biosynthesis|IMP; GO:0006418|tRNA aminoacylation for protein translation|IEA; GO:0006435|threonyl-tRNA aminoacylation|IEA; GO:0016874|ligase activity|IEA

ACL00003326

unclassified

ACL00003327

unclassified

ACL00003328

sid3 protein

Septum-promoting GTP-binding protein 1 related cluster

563

3e-57

66% (112/169)

General function prediction only

GO:0000910|cytokinesis|IEA; GO:0000910|cytokinesis|IMP; GO:0000917|barrier septum formation|IMP; GO:0003924|GTPase activity|TAS; GO:0005525|GTP binding|IEA; GO:0005816|spindle pole body|IDA; GO:0007067|mitosis|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00003329

unclassified

ACL00003330

Immunophilin related cluster

287

1e-25

63% (59/93)

5.2.1.8

GO:0006457|protein folding|IEA

ACL00003331

unclassified

ACL00003332

TT_ORF1 domain containing protein

127

6e-08

36% (34/93)

ACL00003333

unclassified

ACL00003334

unclassified

ACL00003335

Ahsa1

Activator of 90 kDa heat shock protein ATPase homolog 1 related cluster

505

6e-50

32% (108/330)

Posttranslational modification, protein turnover, chaperones

GO:0001671|ATPase stimulator activity|ISS; GO:0005515|protein binding|IPI; GO:0005737|cytoplasm|ISS; GO:0006457|protein folding|IEA; GO:0006457|protein folding|ISS; GO:0006950|response to stress|ISS; GO:0030189|chaperone activator activity|ISS; GO:0051082|unfolded protein binding|IEA

ACL00003336

Granulin domain containing protein

109

4e-06

54% (17/31)

ACL00003337

unclassified

ACL00003338

Unknown EST

123

5e-07

50% (19/38)

ACL00003339

Putative saccharopine dehydrogenase related cluster

184

1e-13

77% (34/44)

1.5.1.10

Amino acid transport and metabolism

Lysine biosynthesis Lysine degradation

GO:0004755|saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00003340

unclassified

ACL00003341

T9D9.16; endo/excinuclease amino terminal domain-containing protein

318

7e-29

38% (58/151)

ACL00003343

unclassified

ACL00003344

Ube1x

Ubiquitin activating enzyme related cluster

183

2e-13

41% (48/116)

Coenzyme transport and metabolism

Parkinson's disease

GO:0003824|catalytic activity|IEA; GO:0004839|ubiquitin activating enzyme activity|IEA; GO:0006464|protein modification|IEA; GO:0006512|ubiquitin cycle|IEA

ACL00003345

Ankyrin homolog precursor related cluster

143

7e-09

35% (42/118)

General function prediction only

ACL00003346

unclassified

ACL00003347

Putative aminotransferase related cluster

296

1e-26

47% (58/121)

2.6.1.19

Amino acid transport and metabolism

Alanine and aspartate metabolism Butanoate metabolism Glutamate metabolism Propanoate metabolism beta-Alanine metabolism

GO:0008483|transaminase activity|IEA; GO:0016740|transferase activity|IEA; GO:0030170|pyridoxal phosphate binding|IEA

ACL00003348

nol5a

Nucleolar protein Nop56 related cluster

726

9e-76

75% (141/188)

Translation, ribosomal structure and biogenesis

GO:0003723|RNA binding|TAS; GO:0005634|nucleus|IEA; GO:0005730|nucleolus|TAS; GO:0006364|rRNA processing|TAS; GO:0007046|ribosome biogenesis|IEA; GO:0007046|ribosome biogenesis|TAS

ACL00003349

unclassified

ACL00003350

CP51

Cytochrome P450 51 related cluster

188

1e-13

22% (45/196)

1.14.13.70

Secondary metabolites biosynthesis, transport and catabolism

GO:0004497|monooxygenase activity|IEA; GO:0006118|electron transport|IEA; GO:0008168|methyltransferase activity|IEA; GO:0008398|sterol 14-demethylase activity|IEA; GO:0016020|membrane|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00003351

unclassified

ACL00003352

HESB protein related cluster

231

1e-18

42% (45/105)

GO:0005554|molecular_function unknown|IEA

ACL00003353

DUF566 domain containing protein

112

5e-06

25% (39/153)

ACL00003354

unclassified

ACL00003355

unclassified

ACL00003356

CGI-69

Mitochondrial carrier protein CGI-69 related cluster

157

2e-10

65% (30/46)

GO:0005488|binding|IEA; GO:0005739|mitochondrion|IEA; GO:0006810|transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0019866|inner membrane|IEA

ACL00003357

Caldesmon domain containing protein

111

4e-06

26% (36/135)

ACL00003358

DEF2

Peptide deformylase 2 related cluster

192

2e-14

41% (38/92)

3.5.1.88

Translation, ribosomal structure and biogenesis

GO:0006412|protein biosynthesis|IEA; GO:0008463|formylmethionine deformylase activity|IEA; GO:0016787|hydrolase activity|IEA; GO:0042586|peptide deformylase activity|IEA

ACL00003359

F23N19.10; stress-inducible protein, putative

169

4e-12

42% (35/83)

ACL00003360

multi-domain protein

111

4e-06

38% (23/60)

ACL00003361

CRYZ

Zeta-crystallin related cluster

366

2e-34

41% (76/184)

1.6.5.5

GO:0003677|DNA binding|IEA; GO:0003960|NADPH:quinone reductase activity|IEA; GO:0004024|alcohol dehydrogenase activity, zinc-dependent|IEA; GO:0008270|zinc ion binding|IEA

ACL00003362

RPB8

DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide related cluster

363

4e-34

53% (76/142)

2.7.7.6

GO:0003899|DNA-directed RNA polymerase activity|IEA; GO:0003899|DNA-directed RNA polymerase activity|NAS; GO:0005634|nucleus|IEA; GO:0005634|nucleus|TAS; GO:0006350|transcription|IEA; GO:0006350|transcription|TAS; GO:0008270|zinc ion binding|NAS; GO:0016740|transferase activity|IEA

ACL00003363

Delta-12 oleate desaturase related cluster

378

9e-36

47% (71/151)

1.14.99.-

Lipid transport and metabolism

1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) degradation Androgen and estrogen metabolism Benzoate degradation via hydroxylation Nicotinate and nicotinamide metabolism

GO:0006633|fatty acid biosynthesis|IEA; GO:0006636|fatty acid desaturation|IEA; GO:0008610|lipid biosynthesis|IEA; GO:0016020|membrane|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016717|oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water|IEA; GO:0050184|phosphatidylcholine desaturase activity|IEA

ACL00003364

Putative lipid phosphate phosphatase 3, chloroplast precursor related cluster

356

8e-33

38% (86/223)

Lipid transport and metabolism

GO:0009507|chloroplast|IEA; GO:0016021|integral to membrane|IEA; GO:0016787|hydrolase activity|IEA

ACL00003365

Tmp21

Transmembrane protein Tmp21 precursor related cluster

178

4e-31

37% (46/123)

GO:0005794|Golgi apparatus|IEA; GO:0006810|transport|IEA; GO:0015031|protein transport|IEA; GO:0016021|integral to membrane|IEA

ACL00003366

Ubiquitin-activating enzyme related cluster

676

3e-70

67% (134/199)

Coenzyme transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0004839|ubiquitin activating enzyme activity|IEA; GO:0006464|protein modification|IEA; GO:0006512|ubiquitin cycle|IEA

ACL00003367

DUF1279 domain containing protein

174

2e-13

33% (33/100)

ACL00003368

3HAO

3-hydroxyanthranilate 3,4-dioxygenase related cluster

539

2e-54

53% (103/193)

1.13.11.6

Tryptophan metabolism

GO:0000334|3-hydroxyanthranilate 3,4-dioxygenase activity|IEA; GO:0005506|iron ion binding|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016702|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|IEA

ACL00003369

dnaJ

Chaperone protein dnaJ related cluster

152

1e-09

42% (30/71)

Posttranslational modification, protein turnover, chaperones

GO:0006260|DNA replication|IEA; GO:0006457|protein folding|IEA; GO:0006986|response to unfolded protein|IEA; GO:0051082|unfolded protein binding|IEA

ACL00003370

Terbinafine resistance locus protein YIP1 related cluster

425

6e-41

47% (87/184)

ACL00003371

Unassigned protein

197

7e-15

32% (54/167)

ACL00003372

CYB5-M

Cytochrome b5 outer mitochondrial membrane isoform precursor related cluster

229

8e-19

54% (40/73)

GO:0005739|mitochondrion|IEA; GO:0006118|electron transport|IEA; GO:0016021|integral to membrane|IEA; GO:0019867|outer membrane|IEA

ACL00003373

HPPD

4-hydroxyphenylpyruvate dioxygenase related cluster

598

4e-61

63% (112/177)

1.13.11.27

Tyrosine metabolism

GO:0003868|4-hydroxyphenylpyruvate dioxygenase activity|IEA; GO:0006559|L-phenylalanine catabolism|IEA; GO:0006572|tyrosine catabolism|IEA; GO:0009072|aromatic amino acid family metabolism|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016702|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|IEA

ACL00003374

Similar to Arabidopsis thaliana (Mouse-ear cress). methyltransferase-like protein related cluster

707

7e-74

65% (126/191)

Translation, ribosomal structure and biogenesis

ACL00003375

Probable mannosyltransferase ALG9 related cluster

129

3e-07

32% (40/125)

GO:0000030|mannosyltransferase activity|IMP; GO:0005783|endoplasmic reticulum|IEA; GO:0005783|endoplasmic reticulum|IMP; GO:0006486|protein amino acid glycosylation|IMP; GO:0006488|dolichol-linked oligosaccharide biosynthesis|TAS; GO:0016021|integral to membrane|IEA; GO:0016740|transferase activity|IEA; GO:0016757|transferase activity, transferring glycosyl groups|IEA

ACL00003376

unclassified

ACL00003377

Glutamine synthetase related cluster

131

2e-23

38% (31/80)

6.3.1.2

Amino acid transport and metabolism

Glutamate metabolism Nitrogen metabolism Peptidoglycan biosynthesis

GO:0004356|glutamate-ammonia ligase activity|IEA; GO:0006542|glutamine biosynthesis|IEA; GO:0006807|nitrogen compound metabolism|IEA; GO:0009399|nitrogen fixation|IEA; GO:0016874|ligase activity|IEA

ACL00003378

IMDH

Inosine-5'-monophosphate dehydrogenase related cluster

129

1e-52

36% (28/76)

1.1.1.205

Nucleotide transport and metabolism

Purine metabolism

GO:0003824|catalytic activity|IEA; GO:0003938|IMP dehydrogenase activity|IEA; GO:0006164|purine nucleotide biosynthesis|IEA; GO:0006177|GMP biosynthesis|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00003379

Unassigned protein

66

8e-17

68% (11/16)

ACL00003380

unclassified

ACL00003381

APC_basic domain containing protein

107

1e-05

23% (28/117)

ACL00003382

Similar to 3-oxoacid CoA transferase related cluster

389

3e-37

68% (80/117)

2.8.3.5

Lipid transport and metabolism

Butanoate metabolism Synthesis and degradation of ketone bodies Valine, leucine and isoleucine degradation

GO:0008152|metabolism|IEA; GO:0008410|CoA-transferase activity|IEA

ACL00003384

H2A domain containing protein

101

2e-06

41% (24/58)

ACL00003385

F24J8.5; F-box family protein

60

1e-06

27% (27/99)

ACL00003386

Cytochrome P450 93A2 related cluster

249

6e-21

35% (55/153)

Secondary metabolites biosynthesis, transport and catabolism

GO:0004497|monooxygenase activity|IEA; GO:0006118|electron transport|IEA; GO:0016020|membrane|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00003387

multi-domain protein

153

1e-10

20% (56/274)

ACL00003388

unclassified

ACL00003389

unclassified

ACL00003390

Rab11a

Ras-related protein Rab-11A related cluster

130

2e-78

92% (25/27)

GO:0005525|GTP binding|TAS

ACL00003392

M2C1

Alpha-mannosidase 2C1 related cluster

164

3e-11

43% (44/101)

3.2.1.24

N-Glycan degradation

GO:0004559|alpha-mannosidase activity|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0016787|hydrolase activity|IEA; GO:0016798|hydrolase activity, acting on glycosyl bonds|IEA

ACL00003393

MFG13.12; arginine-aspartate-rich RNA binding protein-related

248

3e-21

35% (46/128)

RNA processing and modification

ACL00003394

unclassified

ACL00003395

unclassified

ACL00003396

unclassified

ACL00003397

Cathepsin B-like CP2 precursor related cluster

124

2e-06

28% (40/142)

GO:0004197|cysteine-type endopeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008234|cysteine-type peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00003400

cct2

CCT chaperonin beta subunit related cluster

592

1e-60

60% (120/198)

Posttranslational modification, protein turnover, chaperones

GO:0005524|ATP binding|IEA; GO:0006457|protein folding|IEA; GO:0051082|unfolded protein binding|IEA

ACL00003401

DUF566 domain containing protein

113

4e-06

21% (42/200)

ACL00003402

unclassified

ACL00003403

Ras-related protein Rac2 related cluster

375

3e-35

44% (73/163)

GO:0002009|morphogenesis of an epithelium|TAS; GO:0003924|GTPase activity|TAS; GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0007391|dorsal closure|TAS; GO:0007424|tracheal system development (sensu Insecta)|IGI; GO:0007426|tracheal outgrowth (sensu Insecta)|IGI; GO:0007520|myoblast fusion|TAS

ACL00003404

unclassified

ACL00003405

Apyrase related cluster

55

2e-29

36% (12/33)

GO:0004050|apyrase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00003406

unclassified

ACL00003407

unclassified

ACL00003409

Importin-alpha re-exporter related cluster

43

1e-36

37% (9/24)

Cell cycle control, cell division, chromosome partitioning

GO:0000059|protein-nucleus import, docking|IEA; GO:0005488|binding|IEA; GO:0005634|nucleus|IEA; GO:0005643|nuclear pore|IEA; GO:0005737|cytoplasm|IEA; GO:0006810|transport|IEA; GO:0006915|apoptosis|IEA; GO:0008262|importin-alpha export receptor activity|IEA; GO:0008283|cell proliferation|IEA; GO:0008565|protein transporter activity|IEA; GO:0015031|protein transport|IEA

ACL00003410

unclassified

ACL00003411

AP1B1

Adapter-related protein complex 1 beta 1 subunit related cluster

296

6e-26

37% (79/209)

GO:0005215|transporter activity|TAS; GO:0005515|protein binding|IPI; GO:0005794|Golgi apparatus|IEA; GO:0005905|coated pit|IEA; GO:0006461|protein complex assembly|IEA; GO:0006810|transport|IEA; GO:0006886|intracellular protein transport|IEA; GO:0006897|endocytosis|IEA; GO:0015031|protein transport|IEA; GO:0030130|clathrin coat of trans-Golgi network vesicle|IEA

ACL00003412

unclassified

ACL00003413

unclassified

ACL00003414

rac GTPase activating protein 1

367

2e-34

41% (85/204)

ACL00003415

unclassified

ACL00003416

unclassified

ACL00003417

Probable Ni-binding urease accessory protein related cluster

182

2e-13

61% (33/54)

GO:0006461|protein complex assembly|IEA; GO:0016151|nickel ion binding|IEA

ACL00003418

unclassified

ACL00003419

Transformation-sensitive protein homolog related cluster

198

2e-57

72% (40/55)

GO:0004629|phospholipase C activity|IEA; GO:0005488|binding|IEA; GO:0007165|signal transduction|IEA; GO:0007242|intracellular signaling cascade|IEA

ACL00003420

SYQ

Glutaminyl-tRNA synthetase related cluster

497

7e-50

63% (92/145)

6.1.1.18

Translation, ribosomal structure and biogenesis

GO:0004812|tRNA ligase activity|IEA; GO:0004818|glutamate-tRNA ligase activity|IEA; GO:0004819|glutamine-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006418|tRNA aminoacylation for protein translation|IEA; GO:0006424|glutamyl-tRNA aminoacylation|IEA; GO:0016874|ligase activity|IEA

ACL00003421

FH protein interacting protein FIP2 related cluster

157

8e-10

38% (40/103)

GO:0005249|voltage-gated potassium channel activity|IEA; GO:0005515|protein binding|IEA; GO:0006813|potassium ion transport|IEA; GO:0008076|voltage-gated potassium channel complex|IEA; GO:0016020|membrane|IEA

ACL00003422

Cysteine proteinase CPW2 related cluster

504

5e-50

65% (93/142)

Posttranslational modification, protein turnover, chaperones

GO:0004197|cysteine-type endopeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008234|cysteine-type peptidase activity|IEA

ACL00003423

unclassified

ACL00003424

Churchill protein related cluster

215

3e-17

48% (36/75)

GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0007275|development|IEA; GO:0008270|zinc ion binding|IEA; GO:0016563|transcriptional activator activity|IEA; GO:0045941|positive regulation of transcription|IEA

ACL00003425

multi-domain protein

123

2e-07

57% (26/45)

ACL00003426

unclassified

ACL00003427

unclassified

ACL00003428

unclassified

ACL00003429

unclassified

ACL00003430

unclassified

ACL00003431

Unassigned protein

ACL00003432

StAR-related lipid transfer protein 5 related cluster

152

2e-09

27% (51/188)

GO:0006694|steroid biosynthesis|IEA; GO:0006810|transport|IEA; GO:0006869|lipid transport|IEA; GO:0008289|lipid binding|IEA; GO:0015485|cholesterol binding|IEA; GO:0017127|cholesterol transporter activity|IEA

ACL00003433

Unassigned protein

117

5e-06

27% (30/108)

ACL00003434

multi-domain protein

125

6e-08

40% (25/62)

ACL00003435

Herpes_gp2 domain containing protein

111

4e-06

27% (40/143)

ACL00003436

unclassified

ACL00003437

Methionine aminopeptidase, type I, putative related cluster

159

1e-10

46% (36/78)

Translation, ribosomal structure and biogenesis

GO:0004177|aminopeptidase activity|IEA; GO:0004239|methionyl aminopeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008233|peptidase activity|IEA; GO:0008235|metalloexopeptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00003438

Response regulator 9 related cluster

152

1e-09

37% (35/94)

2.7.3.-

GO:0000156|two-component response regulator activity|IEA; GO:0000160|two-component signal transduction system (phosphorelay)|IEA; GO:0003677|DNA binding|IEA; GO:0005634|nucleus|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0007600|sensory perception|IEA

ACL00003439

URKL1

Uridine kinase-like 1 related cluster

344

7e-32

38% (69/180)

Nucleotide transport and metabolism

GO:0004849|uridine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0009058|biosynthesis|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00003440

unclassified

ACL00003441

LCB1

Serine palmitoyltransferase 1 related cluster

139

4e-08

34% (33/95)

2.3.1.50

Glycosphingolipid metabolism

GO:0003824|catalytic activity|IEA; GO:0004758|serine C-palmitoyltransferase activity|IEA; GO:0004758|serine C-palmitoyltransferase activity|TAS; GO:0005783|endoplasmic reticulum|IEA; GO:0006665|sphingolipid metabolism|TAS; GO:0008415|acyltransferase activity|IEA; GO:0009058|biosynthesis|IEA; GO:0016021|integral to membrane|IEA; GO:0016740|transferase activity|IEA

ACL00003443

unclassified

ACL00003444

unclassified

ACL00003445

Similar to U3 snoRNP-associated 55-kDa protein related cluster

334

7e-31

44% (66/148)

ACL00003446

TUBGCP6

Gamma-tubulin complex component 6 related cluster

151

5e-09

27% (50/182)

GO:0000226|microtubule cytoskeleton organization and biogenesis|IEA; GO:0000922|spindle pole|IEA; GO:0005815|microtubule organizing center|IEA; GO:0007020|microtubule nucleation|IDA; GO:0008017|microtubule binding|IDA; GO:0008274|gamma-tubulin ring complex|IDA

ACL00003447

Small GTPase rabE related cluster

176

1e-12

70% (36/51)

General function prediction only

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00003448

RIR2

Ribonucleoside-diphosphate reductase small chain related cluster

523

6e-53

75% (99/131)

1.17.4.1

Nucleotide transport and metabolism

Purine metabolism Pyrimidine metabolism

GO:0004748|ribonucleoside-diphosphate reductase activity|IEA; GO:0006260|DNA replication|IEA; GO:0009186|deoxyribonucleoside diphosphate metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00003449

METE

5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase related cluster

284

3e-25

51% (59/114)

2.1.1.14

Methionine metabolism

GO:0003871|5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity|IEA; GO:0008168|methyltransferase activity|IEA; GO:0009086|methionine biosynthesis|IEA; GO:0016740|transferase activity|IEA

ACL00003450

Putative ubiquitin-conjugating enzyme related cluster

321

3e-29

47% (64/135)

Posttranslational modification, protein turnover, chaperones

GO:0004840|ubiquitin conjugating enzyme activity|IEA; GO:0006464|protein modification|IEA; GO:0006512|ubiquitin cycle|IEA; GO:0016874|ligase activity|IEA

ACL00003451

CBPA2

Carboxypeptidase A2 precursor related cluster

415

8e-40

41% (95/230)

3.4.17.15

Amino acid transport and metabolism

GO:0004180|carboxypeptidase activity|IEA; GO:0004182|carboxypeptidase A activity|IEA; GO:0004182|carboxypeptidase A activity|TAS; GO:0006508|proteolysis and peptidolysis|IEA; GO:0006508|proteolysis and peptidolysis|NR; GO:0007039|vacuolar protein catabolism|TAS; GO:0008237|metallopeptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00003453

Putative TPR repeat protein related cluster

108

1e-09

41% (26/63)

General function prediction only

GO:0005488|binding|IEA

ACL00003454

Unassigned protein

ACL00003455

CulB related cluster

450

3e-44

45% (93/206)

GO:0007049|cell cycle|IEA

ACL00003456

Tandem PH domain-containing protein-2 related cluster

126

1e-06

33% (38/114)

ACL00003457

Unassigned protein

212

1e-16

44% (40/90)

ACL00003458

unclassified

ACL00003459

MTA70

N6-adenosine-methyltransferase 70 kDa subunit related cluster

95

2e-16

37% (25/66)

2.1.1.62

GO:0001510|RNA methylation|NAS; GO:0003723|RNA binding|IEA; GO:0005634|nucleus|IDA; GO:0005634|nucleus|IEA; GO:0006139|nucleobase, nucleoside, nucleotide and nucleic acid metabolism|IEA; GO:0008168|methyltransferase activity|IEA; GO:0016422|mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity|IEA; GO:0016422|mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity|NAS; GO:0016740|transferase activity|IEA

ACL00003460

ubiquitin-specific protease

119

3e-06

41% (23/55)

ACL00003461

Putative exported protein related cluster

132

1e-07

28% (29/103)

GO:0005488|binding|IEA

ACL00003462

Unassigned protein

263

2e-22

44% (52/118)

ACL00003463

unclassified

ACL00003464

putative methyltransferase [EC:2.1.1.-]

275

8e-24

33% (73/218)

2.1.1.-

Aminophosphonate metabolism Androgen and estrogen metabolism Histidine metabolism Nitrobenzene degradation Selenoamino acid metabolism Tryptophan metabolism Tyrosine metabolism Ubiquinone biosynthesis

ACL00003466

THRC

Threonine synthase related cluster

509

6e-51

52% (95/182)

4.2.3.1

Amino acid transport and metabolism

Glycine, serine and threonine metabolism Vitamin B6 metabolism

GO:0003824|catalytic activity|IEA; GO:0004795|threonine synthase activity|IEA; GO:0006520|amino acid metabolism|IEA; GO:0008152|metabolism|IEA; GO:0009088|threonine biosynthesis|IEA; GO:0016829|lyase activity|IEA

ACL00003467

unclassified

ACL00003468

Related to lincomycin-condensing protein lmbA related cluster

130

5e-60

37% (33/87)

GO:0003840|gamma-glutamyltransferase activity|IEA

ACL00003469

unclassified

ACL00003470

unclassified

ACL00003471

unclassified

ACL00003472

unclassified

ACL00003473

HOSM

Homocitrate synthase, mitochondrial precursor related cluster

752

8e-79

68% (149/216)

2.3.3.14

Amino acid transport and metabolism

Lysine biosynthesis Pyruvate metabolism

GO:0003824|catalytic activity|IEA; GO:0004410|homocitrate synthase activity|IEA; GO:0005739|mitochondrion|IEA; GO:0008152|metabolism|IEA; GO:0009085|lysine biosynthesis|IEA; GO:0016740|transferase activity|IEA; GO:0016829|lyase activity|IEA

ACL00003474

Srd5a1

Inferred: 3-OXO-5-alpha-steroid 4-dehydrogenase 1 related cluster

156

2e-10

55% (31/56)

GO:0003865|3-oxo-5-alpha-steroid 4-dehydrogenase activity|IEA; GO:0003865|3-oxo-5-alpha-steroid 4-dehydrogenase activity|IMP; GO:0006702|androgen biosynthesis|IMP; GO:0016021|integral to membrane|IEA

ACL00003475

unclassified

ACL00003476

gpi2, nagB

Glucosamine-6-phosphate isomerase 2 related cluster

234

6e-19

33% (68/204)

3.5.99.6

Carbohydrate transport and metabolism

Aminosugars metabolism

GO:0004342|glucosamine-6-phosphate deaminase activity|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0016787|hydrolase activity|IEA; GO:0016853|isomerase activity|IEA

ACL00003477

Siva domain containing protein

115

2e-06

37% (22/58)

ACL00003478

unclassified

ACL00003479

unclassified

ACL00003480

ABM domain containing protein

120

3e-07

25% (14/56)

ACL00003481

unclassified

ACL00003482

unclassified

ACL00003483

Leucine-rich-repeat protein related cluster

218

1e-17

40% (48/120)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00003484

unclassified

ACL00003485

unclassified

ACL00003486

CG3263

cAMP-dependent protein kinase regulatory chain related cluster

255

2e-21

54% (53/97)

Signal transduction mechanisms

GO:0005952|cAMP-dependent protein kinase complex|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0008603|cAMP-dependent protein kinase regulator activity|IEA; GO:0030552|3',5'-cAMP binding|IEA

ACL00003487

Prim2

DNA primase large subunit related cluster

716

2e-74

42% (145/343)

2.7.7.7

Replication, recombination and repair

DNA polymerase Purine metabolism Pyrimidine metabolism

GO:0003677|DNA binding|IEA; GO:0003896|DNA primase activity|IEA; GO:0003899|DNA-directed RNA polymerase activity|IEA; GO:0005658|alpha DNA polymerase:primase complex|IEA; GO:0006260|DNA replication|IEA; GO:0006269|DNA replication, synthesis of RNA primer|IEA; GO:0016740|transferase activity|IEA

ACL00003488

PHS1

Glycogen phosphorylase 1 related cluster

412

8e-40

56% (85/150)

2.4.1.1

Carbohydrate transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0004645|phosphorylase activity|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0005977|glycogen metabolism|IEA; GO:0016740|transferase activity|IEA; GO:0016757|transferase activity, transferring glycosyl groups|IEA

ACL00003489

unclassified

ACL00003490

unclassified

ACL00003491

PSA2

Proteasome subunit alpha type 2 related cluster

46

2e-26

64% (9/14)

3.4.25.1

Posttranslational modification, protein turnover, chaperones

Proteasome

GO:0004175|endopeptidase activity|IEA; GO:0005829|cytosol|IEA; GO:0005839|proteasome core complex (sensu Eukaryota)|IEA; GO:0006511|ubiquitin-dependent protein catabolism|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00003492

UPF0136 domain containing protein

144

2e-10

41% (28/67)

ACL00003493

Subtilisin-like serine proteinase related cluster

511

2e-51

62% (97/156)

Posttranslational modification, protein turnover, chaperones

GO:0004252|serine-type endopeptidase activity|IEA; GO:0004289|subtilase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA; GO:0042802|protein self binding|IEA; GO:0043086|negative regulation of enzyme activity|IEA

ACL00003494

[LDA] COG5049 5'-3' exonuclease

166

4e-12

32% (47/145)

ACL00003495

unclassified

ACL00003496

UBE2M

Ubiquitin-conjugating enzyme E2 M related cluster

85

6e-19

83% (15/18)

6.3.2.19

Posttranslational modification, protein turnover, chaperones

GO:0004840|ubiquitin conjugating enzyme activity|IEA; GO:0004842|ubiquitin-protein ligase activity|IEA; GO:0006464|protein modification|IEA; GO:0006512|ubiquitin cycle|IEA; GO:0016874|ligase activity|IEA

ACL00003497

unclassified

ACL00003498

unclassified

ACL00003499

COG0776: Bacterial nucleoid DNA-binding protein [Microbulbifer degradans 2-40]

122

5e-06

35% (36/101)

ACL00003500

Unassigned protein

272

3e-23

60% (57/95)

ACL00003501

unclassified

ACL00003502

unclassified

ACL00003503

Unassigned protein

132

4e-07

35% (39/110)

ACL00003505

CP51

Cytochrome P450 51 related cluster

138

2e-67

43% (25/57)

1.14.13.70

Secondary metabolites biosynthesis, transport and catabolism

GO:0004497|monooxygenase activity|IEA; GO:0006118|electron transport|IEA; GO:0008168|methyltransferase activity|IEA; GO:0008398|sterol 14-demethylase activity|IEA; GO:0016020|membrane|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00003506

Molybdenum cofactor biosynthesis protein related cluster

153

9e-10

29% (34/115)

Coenzyme transport and metabolism

GO:0003824|catalytic activity|IEA

ACL00003507

Putative cullin related cluster

935

1e-100

58% (182/309)

Posttranslational modification, protein turnover, chaperones

GO:0007049|cell cycle|IEA

ACL00003508

unclassified

ACL00003509

unclassified

ACL00003510

unclassified

ACL00003511

Putative trehalose synthase related cluster

121

2e-43

38% (19/50)

GO:0004556|alpha-amylase activity|IEA; GO:0005975|carbohydrate metabolism|IEA

ACL00003512

P5CS

Delta 1-pyrroline-5-carboxylate synthetase related cluster

283

4e-25

47% (59/124)

1.2.1.41

GO:0003824|catalytic activity|IEA; GO:0004349|glutamate 5-kinase activity|IEA; GO:0004350|glutamate-5-semialdehyde dehydrogenase activity|IEA; GO:0005737|cytoplasm|IEA; GO:0006561|proline biosynthesis|IEA; GO:0008652|amino acid biosynthesis|IEA; GO:0016301|kinase activity|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016740|transferase activity|IEA

ACL00003513

Apoptosis-related protein related cluster

202

1e-15

58% (43/73)

ACL00003514

unclassified

ACL00003515

unclassified

ACL00003516

unclassified

ACL00003517

Ssr2

Translocon-associated protein, beta subunit precursor related cluster

199

8e-15

32% (49/152)

GO:0005048|signal sequence binding|TAS; GO:0005783|endoplasmic reticulum|IEA; GO:0005783|endoplasmic reticulum|TAS; GO:0006613|cotranslational protein-membrane targeting|TAS; GO:0016021|integral to membrane|IEA; GO:0016021|integral to membrane|TAS

ACL00003518

DUF300 domain containing protein

122

3e-07

29% (25/84)

ACL00003519

unclassified

ACL00003520

unclassified

ACL00003521

rpsQ

30S ribosomal protein S17 related cluster

143

9e-09

37% (28/74)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0019843|rRNA binding|IEA

ACL00003522

unclassified

ACL00003523

Drf_FH1 domain containing protein

114

2e-06

37% (36/97)

ACL00003524

unclassified

ACL00003525

unclassified

ACL00003526

Rac serine/threonine kinase homolog related cluster

412

1e-39

42% (88/208)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00003527

multi-domain protein

117

4e-07

36% (24/66)

ACL00003528

unclassified

ACL00003529

LAG1 homolog 2 related cluster

259

8e-22

29% (58/199)

GO:0016021|integral to membrane|IEA

ACL00003530

unclassified

ACL00003531

unclassified

ACL00003532

COG4

COG4; component of oligomeric golgi complex 4

114

9e-26

27% (22/81)

ACL00003533

unclassified

ACL00003534

unclassified

ACL00003535

unclassified

ACL00003536

unclassified

ACL00003537

unclassified

ACL00003538

Oxysterol binding protein-related protein 6 related cluster

134

8e-08

38% (33/85)

GO:0006810|transport|IEA; GO:0006869|lipid transport|IEA; GO:0008202|steroid metabolism|IEA

ACL00003539

Molybdopterin biosynthesis CNX2 protein related cluster

823

5e-87

52% (164/311)

Coenzyme transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0005506|iron ion binding|IEA; GO:0006777|Mo-molybdopterin cofactor biosynthesis|IEA; GO:0019008|molybdopterin synthase complex|IEA

ACL00003540

unclassified

ACL00003541

GTP-binding protein related cluster

54

1e-26

54% (13/24)

Translation, ribosomal structure and biogenesis

GO:0005525|GTP binding|IEA; GO:0005554|molecular_function unknown|IEA

ACL00003543

multi-domain protein

116

1e-06

26% (42/157)

ACL00003544

Unassigned protein

ACL00003547

Signal recognition particle 19 kDa protein related cluster

119

8e-22

65% (21/32)

Intracellular trafficking, secretion, and vesicular transport

Protein export

GO:0003723|RNA binding|IEA; GO:0005786|signal recognition particle (sensu Eukaryota)|IEA; GO:0006605|protein targeting|IEA; GO:0008312|7S RNA binding|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00003548

Unassigned protein

ACL00003549

Tymo_45kd_70kd domain containing protein

113

3e-06

25% (56/221)

ACL00003550

unclassified

ACL00003551

DPD2

DNA polymerase delta small subunit related cluster

463

9e-46

53% (87/164)

2.7.7.7

Replication, recombination and repair

DNA polymerase Purine metabolism Pyrimidine metabolism

GO:0003887|DNA-directed DNA polymerase activity|IEA; GO:0005634|nucleus|IEA; GO:0006260|DNA replication|IEA; GO:0016740|transferase activity|IEA

ACL00003552

Pfdn5

Prefoldin subunit 5 related cluster

210

1e-16

43% (39/89)

Posttranslational modification, protein turnover, chaperones

GO:0003714|transcription corepressor activity|TAS; GO:0005515|protein binding|IEA; GO:0005634|nucleus|TAS; GO:0006355|regulation of transcription, DNA-dependent|TAS; GO:0006457|protein folding|IEA; GO:0016272|prefoldin complex|IEA; GO:0051082|unfolded protein binding|IEA

ACL00003553

ARGI

Arginase related cluster

207

3e-16

42% (50/119)

3.5.3.1

Amino acid transport and metabolism

Arginine and proline metabolism Urea cycle and metabolism of amino groups

GO:0003824|catalytic activity|IEA; GO:0004053|arginase activity|IEA; GO:0006525|arginine metabolism|IEA; GO:0006527|arginine catabolism|IEA; GO:0016787|hydrolase activity|IEA; GO:0030145|manganese ion binding|IEA

ACL00003554

unclassified

ACL00003556

unclassified

ACL00003557

Cycloartenol synthase related cluster

455

5e-45

59% (78/132)

GO:0003824|catalytic activity|IEA; GO:0008152|metabolism|IEA; GO:0016829|lyase activity|IEA

ACL00003558

unclassified

ACL00003559

Glycosyl hydrolase, family 15 related cluster

129

8e-07

29% (37/125)

Carbohydrate transport and metabolism

GO:0016787|hydrolase activity|IEA

ACL00003560

Disulfide bond formation protein, putative related cluster

214

1e-16

56% (46/81)

GO:0005783|endoplasmic reticulum|IEA; GO:0006118|electron transport|IEA; GO:0006810|transport|IEA; GO:0016020|membrane|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00003561

unclassified

ACL00003562

Clathrin coat assembly like protein related cluster

244

1e-20

38% (49/127)

GO:0006886|intracellular protein transport|IEA; GO:0030125|clathrin vesicle coat|IEA

ACL00003563

Sdh_cyt domain containing protein

139

1e-09

38% (19/49)

ACL00003564

CYAA

Adenylate cyclase related cluster

200

4e-15

55% (36/65)

4.6.1.1

Signal transduction mechanisms

Purine metabolism

GO:0000287|magnesium ion binding|IEA; GO:0003824|catalytic activity|IEA; GO:0004016|adenylate cyclase activity|IEA; GO:0004383|guanylate cyclase activity|IEA; GO:0006171|cAMP biosynthesis|IEA; GO:0007165|signal transduction|IEA; GO:0007242|intracellular signaling cascade|IEA; GO:0016829|lyase activity|IEA

ACL00003565

[R] COG4099 Predicted peptidase

174

9e-13

36% (39/106)

General function prediction only

ACL00003566

Acetylornitine deacetylase related cluster

419

9e-41

53% (83/155)

Amino acid transport and metabolism

GO:0006508|proteolysis and peptidolysis|IEA; GO:0008237|metallopeptidase activity|IEA; GO:0009014|succinyl-diaminopimelate desuccinylase activity|IEA; GO:0009085|lysine biosynthesis|IEA; GO:0046872|metal ion binding|IEA

ACL00003567

Aa_trans domain containing protein

117

7e-07

21% (20/92)

ACL00003568

MCM domain containing protein

133

8e-10

80% (20/25)

ACL00003569

GHMP_kinases domain containing protein

113

2e-06

32% (21/65)

ACL00003570

PPB

Repressible alkaline phosphatase precursor related cluster

195

1e-14

29% (46/155)

3.1.3.1

Inorganic ion transport and metabolism

GO:0000287|magnesium ion binding|IEA; GO:0000329|vacuolar membrane (sensu Fungi)|IDA; GO:0004035|alkaline phosphatase activity|IDA; GO:0004035|alkaline phosphatase activity|IEA; GO:0006470|protein amino acid dephosphorylation|IDA; GO:0008152|metabolism|IEA; GO:0016021|integral to membrane|IEA; GO:0016576|histone dephosphorylation|IDA; GO:0016787|hydrolase activity|IEA

ACL00003571

unclassified

ACL00003573

HSPC049 protein related cluster

223

7e-18

31% (58/187)

ACL00003574

unclassified

ACL00003575

Endoglucanase E precursor related cluster

168

9e-12

35% (41/117)

GO:0003824|catalytic activity|IEA

ACL00003576

Transcription initiation factor TFIID subunit 13 related cluster

281

1e-24

53% (50/94)

Transcription

GO:0003700|transcription factor activity|TAS; GO:0003702|RNA polymerase II transcription factor activity|IEA; GO:0005515|protein binding|TAS; GO:0005634|nucleus|IEA; GO:0005667|transcription factor complex|IEA; GO:0005669|transcription factor TFIID complex|TAS; GO:0006352|transcription initiation|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0016251|general RNA polymerase II transcription factor activity|TAS

ACL00003577

Structural maintenance of chromosomes (SMC)-like protein related cluster

131

2e-07

33% (29/86)

GO:0005524|ATP binding|IEA; GO:0005634|nucleus|IEA; GO:0007001|chromosome organization and biogenesis (sensu Eukaryota)|IEA; GO:0016887|ATPase activity|IEA

ACL00003578

TT_ORF1 domain containing protein

107

6e-06

43% (17/39)

ACL00003579

Endonuclease related cluster

123

2e-06

42% (32/75)

GO:0003676|nucleic acid binding|IEA; GO:0004519|endonuclease activity|IEA; GO:0006308|DNA catabolism|IEA

ACL00003580

multi-domain protein

84

1e-04

14% (7/50)

ACL00003581

unclassified

ACL00003582

Dnaja2

DnaJ homolog subfamily A member 2 related cluster

378

5e-36

52% (67/127)

Posttranslational modification, protein turnover, chaperones

GO:0000074|regulation of cell cycle|TAS; GO:0000080|G1 phase of mitotic cell cycle|NR; GO:0006457|protein folding|IEA; GO:0008284|positive regulation of cell proliferation|TAS; GO:0016020|membrane|IEA; GO:0051082|unfolded protein binding|IEA

ACL00003583

multi-domain protein

118

7e-07

42% (31/73)

ACL00003584

unclassified

ACL00003585

unclassified

ACL00003586

Atrophin-1 domain containing protein

109

9e-06

19% (37/189)

ACL00003587

Unassigned protein

ACL00003588

GTP-binding protein YPTC5 related cluster

182

2e-13

40% (48/120)

General function prediction only

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00003589

multi-domain protein

110

6e-06

26% (38/144)

ACL00003590

unclassified

ACL00003591

unclassified

ACL00003592

probable short-chain dehydrogenase [EC:1.-.-.-]

471

1e-46

49% (96/193)

1.-.-.-

General function prediction only

ACL00003593

DUF1421 domain containing protein

107

8e-06

38% (25/65)

ACL00003594

unclassified

ACL00003595

Putative 26S proteasome subunit related cluster

720

6e-75

42% (145/342)

GO:0005829|cytosol|IEA

ACL00003596

exocyst subunit EXO70 family protein [Arabidopsis thaliana]

130

2e-06

25% (41/160)

ACL00003597

Unassigned protein

ACL00003598

unclassified

ACL00003599

multi-domain protein

98

4e-06

44% (16/36)

ACL00003600

multi-domain protein

128

4e-08

35% (28/80)

ACL00003601

Probable copper homeostasis protein related cluster

462

3e-45

43% (100/229)

Inorganic ion transport and metabolism

GO:0004807|triose-phosphate isomerase activity|IEA; GO:0006878|copper ion homeostasis|IEA; GO:0008152|metabolism|IEA

ACL00003602

Putative glucosamine-6-phosphate deaminase-like protein BT0258 related cluster

77

2e-48

54% (17/31)

3.5.99.6

Aminosugars metabolism

GO:0004342|glucosamine-6-phosphate deaminase activity|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0006044|N-acetylglucosamine metabolism|IEA

ACL00003603

unclassified

ACL00003604

unclassified

ACL00003605

Crystal protein precursor related cluster

198

3e-15

37% (52/140)

GO:0003824|catalytic activity|IEA; GO:0004759|serine esterase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00003606

Squalene synthase related cluster

46

4e-38

75% (9/12)

2.5.1.21

Lipid transport and metabolism

Biosynthesis of steroids Terpenoid biosynthesis

GO:0004310|farnesyl-diphosphate farnesyltransferase activity|IEA; GO:0008610|lipid biosynthesis|IEA; GO:0009058|biosynthesis|IEA; GO:0016021|integral to membrane|IEA; GO:0016740|transferase activity|IEA

ACL00003607

N-acyl-D-glucosamine 2-epimerase related cluster

596

7e-61

50% (117/230)

Carbohydrate transport and metabolism

ACL00003608

Protein kinase ATN1-like protein related cluster

130

2e-07

32% (27/83)

GO:0004672|protein kinase activity|IEA; GO:0004713|protein-tyrosine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA

ACL00003609

DUF1394 domain containing protein

212

1e-17

50% (35/69)

ACL00003610

multi-domain protein

493

2e-50

45% (74/162)

ACL00003611

Vacuolar protein sorting 11 related cluster

361

9e-34

38% (68/176)

GO:0000151|ubiquitin ligase complex|IEA; GO:0004842|ubiquitin-protein ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006810|transport|IEA; GO:0008270|zinc ion binding|IEA; GO:0015031|protein transport|IEA; GO:0016020|membrane|IEA; GO:0016567|protein ubiquitination|IEA

ACL00003612

Forkhead-associated domain histidine-triad like protein related cluster

356

2e-33

47% (74/157)

GO:0003676|nucleic acid binding|IEA; GO:0005634|nucleus|IEA; GO:0006281|DNA repair|IEA; GO:0008270|zinc ion binding|IEA

ACL00003613

unclassified

ACL00003614

unclassified

ACL00003615

unclassified

ACL00003616

TRMB

tRNA (guanine-N(7)-)-methyltransferase related cluster

515

1e-51

67% (98/145)

2.1.1.33

General function prediction only

GO:0006400|tRNA modification|IDA; GO:0008033|tRNA processing|IEA; GO:0008168|methyltransferase activity|IEA; GO:0008168|methyltransferase activity|TAS; GO:0008176|tRNA (guanine-N7-)-methyltransferase activity|IDA; GO:0008176|tRNA (guanine-N7-)-methyltransferase activity|IEA; GO:0008372|cellular_component unknown|ND; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00003617

multi-domain protein

136

1e-08

22% (35/159)

ACL00003619

unclassified

ACL00003620

HSPC177 related cluster

144

2e-31

50% (29/57)

GO:0005554|molecular_function unknown|IEA

ACL00003621

Similar to proteasome (Prosome, macropain) 26S subunit, non-ATPase, 1 related cluster

123

9e-23

52% (22/42)

Posttranslational modification, protein turnover, chaperones

GO:0000074|regulation of cell cycle|IEA; GO:0005488|binding|IEA; GO:0005829|cytosol|IEA

ACL00003622

multi-domain protein

117

1e-06

24% (41/166)

ACL00003623

unclassified

ACL00003625

ADAS

Alkyldihydroxyacetonephosphate synthase related cluster

358

2e-33

39% (78/197)

2.5.1.26

Glycerolipid metabolism

GO:0005777|peroxisome|IEA; GO:0006118|electron transport|IEA; GO:0008609|alkylglycerone-phosphate synthase activity|IEA; GO:0008610|lipid biosynthesis|IEA; GO:0016740|transferase activity|IEA

ACL00003626

multi-domain protein

131

9e-09

31% (15/48)

ACL00003627

FAAA

Fumarylacetoacetase related cluster

238

6e-53

47% (53/112)

3.7.1.2

Styrene degradation Tyrosine metabolism

GO:0003824|catalytic activity|IEA; GO:0004334|fumarylacetoacetase activity|IEA; GO:0006559|L-phenylalanine catabolism|IEA; GO:0006572|tyrosine catabolism|IEA; GO:0008152|metabolism|IEA; GO:0009072|aromatic amino acid family metabolism|IEA; GO:0016787|hydrolase activity|IEA

ACL00003628

unclassified

ACL00003629

unclassified

ACL00003630

Cytochrome P450 97B2 related cluster

127

5e-07

25% (31/120)

Secondary metabolites biosynthesis, transport and catabolism

GO:0004497|monooxygenase activity|IEA; GO:0006118|electron transport|IEA; GO:0016020|membrane|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00003631

unclassified

ACL00003632

unclassified

ACL00003633

Hydroxylamine reductase related cluster

335

5e-31

44% (66/148)

GO:0005506|iron ion binding|IEA; GO:0005737|cytoplasm|IEA; GO:0006118|electron transport|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016661|oxidoreductase activity, acting on other nitrogenous compounds as donors|IEA; GO:0050418|hydroxylamine reductase activity|IEA

ACL00003634

multi-domain protein

163

3e-12

32% (43/131)

ACL00003635

LKHA

Probable leukotriene A-4 hydrolase related cluster

80

2e-35

61% (16/26)

3.3.2.6

Prostaglandin and leukotriene metabolism

GO:0003824|catalytic activity|IEA; GO:0004179|membrane alanyl aminopeptidase activity|IEA; GO:0004463|leukotriene-A4 hydrolase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008237|metallopeptidase activity|IEA; GO:0008270|zinc ion binding|IEA; GO:0016787|hydrolase activity|IEA; GO:0019370|leukotriene biosynthesis|IEA

ACL00003636

Deoxyribodipyrimidine photolyase related cluster

76

3e-24

41% (13/31)

Replication, recombination and repair

GO:0003904|deoxyribodipyrimidine photo-lyase activity|IEA; GO:0003913|DNA photolyase activity|IEA; GO:0006281|DNA repair|IEA; GO:0016829|lyase activity|IEA

ACL00003637

Putative coatmer beta subunit related cluster

138

3e-08

70% (31/44)

Intracellular trafficking, secretion, and vesicular transport

GO:0005488|binding|IEA

ACL00003638

F11A17.2; desulfhydrase family

44

8e-16

42% (9/21)

ACL00003639

ugpQ

Glycerophosphoryl diester phosphodiesterase related cluster

240

9e-20

38% (66/172)

3.1.4.46

Energy production and conversion

Glycerolipid metabolism Phospholipid degradation

GO:0006071|glycerol metabolism|IEA; GO:0008889|glycerophosphodiester phosphodiesterase activity|IEA

ACL00003640

Delta 5 fatty acid desaturase related cluster

65

2e-10

26% (20/76)

Lipid transport and metabolism

GO:0016491|oxidoreductase activity|IEA

ACL00003641

unclassified

ACL00003642

unclassified

ACL00003643

Unknown EST

120

2e-06

55% (20/36)

ACL00003644

Putative fatty acid elongation protein 3 related cluster

206

8e-16

41% (51/123)

GO:0016021|integral to membrane|IEA

ACL00003646

unclassified

ACL00003647

Ywhae

14-3-3 protein epsilon related cluster

122

2e-06

63% (26/41)

GO:0005515|protein binding|TAS; GO:0007165|signal transduction|TAS; GO:0007242|intracellular signaling cascade|TAS; GO:0008426|protein kinase C inhibitor activity|TAS; GO:0019899|enzyme binding|IPI

ACL00003648

eIF-2beta

Eukaryotic translation initiation factor 2 beta subunit related cluster

169

7e-12

40% (41/101)

Translation, ribosomal structure and biogenesis

GO:0003743|translation initiation factor activity|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006413|translational initiation|IEA

ACL00003649

Histone H4 related cluster

360

5e-34

95% (70/73)

Chromatin structure and dynamics

GO:0000786|nucleosome|IEA; GO:0003677|DNA binding|IEA; GO:0005634|nucleus|IEA; GO:0005694|chromosome|IEA; GO:0006334|nucleosome assembly|IEA; GO:0007001|chromosome organization and biogenesis (sensu Eukaryota)|IEA

ACL00003650

MAR-binding protein related cluster

390

2e-37

77% (74/95)

ACL00003653

zgc:56049

Ras-related protein Rab-1A related cluster

508

4e-51

68% (102/150)

GO:0003924|GTPase activity|TAS; GO:0016192|vesicle-mediated transport|TAS

ACL00003655

lat

Probable L-lysine-epsilon aminotransferase related cluster

436

1e-42

47% (85/178)

2.6.1.36

Amino acid transport and metabolism

Lysine biosynthesis

ACL00003656

unclassified

ACL00003657

SYT

Threonyl-tRNA synthetase, cytoplasmic related cluster

689

1e-71

69% (129/186)

6.1.1.3

Translation, ribosomal structure and biogenesis

Aminoacyl-tRNA biosynthesis Glycine, serine and threonine metabolism

GO:0004812|tRNA ligase activity|IEA; GO:0004829|threonine-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0005625|soluble fraction|TAS; GO:0005737|cytoplasm|TAS; GO:0006412|protein biosynthesis|IEA; GO:0006412|protein biosynthesis|NR; GO:0006418|tRNA aminoacylation for protein translation|IEA; GO:0006435|threonyl-tRNA aminoacylation|IEA; GO:0016874|ligase activity|IEA

ACL00003658

unclassified

ACL00003659

rap1b

Ras-related protein Rap-1b related cluster

481

2e-47

57% (95/165)

GO:0005525|GTP binding|IEA; GO:0006886|intracellular protein transport|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA; GO:0016020|membrane|TAS

ACL00003660

multi-domain protein

134

1e-08

48% (29/60)

ACL00003663

unclassified

ACL00003666

Ras-like protein rasB related cluster

390

2e-37

53% (78/145)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00003667

multi-domain protein

142

1e-09

33% (20/59)

ACL00003668

Ras-related protein Rab-32 related cluster

451

2e-44

62% (82/131)

GO:0005525|GTP binding|IEA; GO:0005739|mitochondrion|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00003669

rab32

Similar to RAB32, member RAS oncogene family related cluster

525

2e-52

55% (102/184)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00003670

Ras-related protein Rac2 related cluster

570

4e-58

64% (111/172)

GO:0002009|morphogenesis of an epithelium|TAS; GO:0003924|GTPase activity|TAS; GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0007391|dorsal closure|TAS; GO:0007424|tracheal system development (sensu Insecta)|IGI; GO:0007426|tracheal outgrowth (sensu Insecta)|IGI; GO:0007520|myoblast fusion|TAS

ACL00003671

Histone H3 related cluster

370

4e-35

76% (71/93)

Chromatin structure and dynamics

ACL00003672

unclassified

ACL00003673

Peroxidase ppod11 related cluster

161

4e-10

38% (45/118)

GO:0004601|peroxidase activity|IEA

ACL00003674

unclassified

ACL00003675

Polyubiquitin related cluster

592

3e-66

81% (121/149)

ACL00003683

Eukaryotic translation initiation factor 3 subunit 3 related cluster

611

2e-62

54% (129/238)

GO:0003743|translation initiation factor activity|IEA; GO:0006412|protein biosynthesis|IEA

ACL00003688

V-ATPase_G domain containing protein

224

2e-19

37% (36/96)

ACL00003690

Similar to GDP dissociation inhibitor 2 related cluster

46

1e-155

81% (9/11)

GO:0005093|RAB GDP-dissociation inhibitor activity|IEA; GO:0015031|protein transport|IEA; GO:0043087|regulation of GTPase activity|IEA

ACL00003691

unclassified

ACL00003692

K7M2.8; sec20 family protein

141

2e-08

25% (46/179)

ACL00003694

Ribosomal protein L12 related cluster

197

1e-14

32% (61/188)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00003695

DUF566 domain containing protein

113

4e-06

24% (42/173)

ACL00003696

unclassified

ACL00003697

Aminotransferases class-I related cluster

66

4e-08

35% (16/45)

GO:0003824|catalytic activity|IEA; GO:0004069|aspartate transaminase activity|IEA; GO:0008483|transaminase activity|IEA; GO:0009058|biosynthesis|IEA; GO:0016740|transferase activity|IEA

ACL00003698

Eif4e

Eukaryotic translation initiation factor eIF4E-1 related cluster

287

4e-25

52% (51/97)

Translation, ribosomal structure and biogenesis

GO:0003723|RNA binding|IEA; GO:0003743|translation initiation factor activity|IEA; GO:0005737|cytoplasm|IEA; GO:0006413|translational initiation|IEA

ACL00003699

Autophagy protein 8 related cluster

409

1e-39

84% (79/93)

ACL00003700

Putative syntaxin protein related cluster

186

2e-13

41% (36/86)

Intracellular trafficking, secretion, and vesicular transport

ACL00003702

Histone H2B related cluster

398

4e-38

82% (79/96)

GO:0000786|nucleosome|IEA; GO:0000786|nucleosome|NAS; GO:0000786|nucleosome|TAS; GO:0003677|DNA binding|IEA; GO:0003677|DNA binding|NAS; GO:0005634|nucleus|IEA; GO:0005694|chromosome|IEA; GO:0006334|nucleosome assembly|IEA; GO:0006334|nucleosome assembly|NAS; GO:0007001|chromosome organization and biogenesis (sensu Eukaryota)|IEA

ACL00003703

unclassified

ACL00003705

Chorismate_mut domain containing protein

118

4e-07

31% (21/66)

ACL00003707

HPCAL1

HPCAL1; hippocalcin-like 1

176

7e-13

30% (44/144)

ACL00003708

WD-repeat protein BING4 related cluster

324

2e-29

39% (71/182)

General function prediction only

ACL00003709

multi-domain protein

109

6e-06

26% (17/65)

ACL00003714

unclassified

ACL00003715

Ribosomal_S30 domain containing protein

245

9e-22

70% (42/60)

ACL00003716

Unassigned protein

ACL00003717

unclassified

ACL00003720

Rps12

Ribosomal protein S12 related cluster

426

3e-41

66% (80/120)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00003722

Ribosomal protein L30 related cluster

476

4e-47

81% (91/112)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00003723

40S ribosomal protein S23 related cluster

197

5e-59

82% (38/46)

Translation, ribosomal structure and biogenesis

GO:0003723|RNA binding|TAS; GO:0003735|structural constituent of ribosome|TAS; GO:0005843|cytosolic small ribosomal subunit (sensu Eukaryota)|TAS; GO:0006412|protein biosynthesis|TAS

ACL00003737

gar1

snoRNP protein gar1 related cluster

260

2e-22

46% (48/104)

GO:0005634|nucleus|IEA; GO:0006364|rRNA processing|IEA; GO:0007046|ribosome biogenesis|IEA; GO:0019843|rRNA binding|IEA; GO:0030529|ribonucleoprotein complex|IEA; GO:0030532|small nuclear ribonucleoprotein complex|IEA

ACL00003739

Similarity to SNF2/RAD54 family related cluster

252

4e-21

41% (53/128)

GO:0003676|nucleic acid binding|IEA; GO:0003677|DNA binding|IEA; GO:0004386|helicase activity|IEA; GO:0005524|ATP binding|IEA

ACL00003740

unclassified

ACL00003741

unclassified

ACL00003742

unclassified

ACL00003744

unclassified

ACL00003745

TNS

Tensin related cluster

309

2e-27

32% (86/262)

Integrin-mediated cell adhesion

GO:0003779|actin binding|IEA; GO:0005856|cytoskeleton|IEA; GO:0007242|intracellular signaling cascade|IEA

ACL00003746

CG5902

Protein CG5902 related cluster

296

2e-26

43% (64/148)

GO:0000004|biological_process unknown|ND; GO:0005554|molecular_function unknown|ND; GO:0008372|cellular_component unknown|ND

ACL00003747

F-box-like/WD-repeat protein TBLR1 related cluster

94

1e-53

72% (16/22)

General function prediction only

GO:0005634|nucleus|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006512|ubiquitin cycle|IEA

ACL00003748

Lung_7-TM_R domain containing protein

131

5e-09

39% (22/56)

ACL00003749

RRAS2

Ras-related protein R-Ras2 related cluster

141

1e-08

40% (33/82)

MAPK signaling pathway Regulation of actin cytoskeleton

GO:0003924|GTPase activity|TAS; GO:0005783|endoplasmic reticulum|NAS; GO:0005886|plasma membrane|NAS

ACL00003750

AP1M1

Clathrin-adaptor medium chain apm 1 related cluster

110

4e-65

61% (21/34)

GO:0006886|intracellular protein transport|IEA; GO:0030125|clathrin vesicle coat|IEA

ACL00003751

unclassified

ACL00003752

unclassified

ACL00003753

GTP-binding nuclear protein RAN related cluster

257

4e-22

50% (46/91)

General function prediction only

GO:0005525|GTP binding|IEA; GO:0005634|nucleus|IEA; GO:0006810|transport|IEA; GO:0006886|intracellular protein transport|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00003754

CCT5

CCT (Chaperonin containing T-complex polypeptide 1) epsilon subunit related cluster

1161

1e-126

71% (222/309)

Posttranslational modification, protein turnover, chaperones

GO:0005524|ATP binding|IEA; GO:0006457|protein folding|IEA; GO:0051082|unfolded protein binding|IEA

ACL00003755

multi-domain protein

115

2e-06

24% (32/133)

ACL00003756

unclassified

ACL00003757

L-plastin related cluster

125

1e-06

25% (43/166)

Cytoskeleton

GO:0000004|biological_process unknown|ND; GO:0003779|actin binding|IEA; GO:0003779|actin binding|NAS; GO:0005509|calcium ion binding|IEA; GO:0005509|calcium ion binding|NAS; GO:0005737|cytoplasm|NAS; GO:0005829|cytosol|IDA

ACL00003758

Protein kinase-like related cluster

77

5e-10

35% (13/37)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0004713|protein-tyrosine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00003759

DSRM domain containing protein

92

4e-05

30% (23/75)

ACL00003760

unclassified

ACL00003761

Calcineurin B related cluster

127

9e-07

41% (27/65)

GO:0005509|calcium ion binding|IEA

ACL00003762

unclassified

ACL00003763

unclassified

ACL00003764

Unknown EST

53

4e-10

81% (9/11)

ACL00003765

Possible secreted DNA ligase related cluster

48

2e-22

48% (12/25)

6.5.1.1

Replication, recombination and repair

GO:0003910|DNA ligase (ATP) activity|IEA; GO:0005524|ATP binding|IEA; GO:0006260|DNA replication|IEA; GO:0006281|DNA repair|IEA; GO:0006310|DNA recombination|IEA; GO:0016874|ligase activity|IEA

ACL00003767

Molybdenum cofactor sulfurase related cluster

377

1e-35

40% (68/166)

ACL00003768

unclassified

ACL00003769

unclassified

ACL00003770

GTP-binding protein SAS1 related cluster

544

8e-55

59% (99/167)

General function prediction only

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00003771

Peroxisomal membrane protein related cluster

143

1e-08

41% (29/70)

GO:0016021|integral to membrane|IEA

ACL00003772

unclassified

ACL00003773

multi-domain protein

197

1e-15

20% (73/351)

ACL00003774

multi-domain protein

136

9e-09

18% (38/206)

ACL00003775

DUF74 domain containing protein

120

2e-07

31% (18/57)

ACL00003776

unclassified

ACL00003777

unclassified

ACL00003778

unclassified

ACL00003779

SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily D member 1 related cluster

393

2e-37

40% (86/210)

Chromatin structure and dynamics

GO:0005554|molecular_function unknown|ND; GO:0005634|nucleus|IEA; GO:0006338|chromatin remodeling|NAS; GO:0016568|chromatin modification|IEA; GO:0016585|chromatin remodeling complex|NAS

ACL00003780

Putative GTP-binding protein related cluster

186

7e-14

82% (37/45)

General function prediction only

GO:0000160|two-component signal transduction system (phosphorelay)|IEA; GO:0003677|DNA binding|IEA; GO:0005525|GTP binding|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00003781

Similar to Dictyostelium discoideum (Slime mold). histidine kinase A related cluster

260

3e-22

42% (67/157)

ACL00003782

MOV34 ISOLOG related cluster

366

1e-34

44% (72/162)

ACL00003783

Putative transthyretin precursor related cluster

181

3e-13

38% (40/105)

General function prediction only

GO:0005386|carrier activity|IEA; GO:0005496|steroid binding|IEA; GO:0006810|transport|IEA

ACL00003785

unclassified

ACL00003786

unclassified

ACL00003787

SYC

Probable cysteinyl-tRNA synthetase related cluster

253

5e-46

51% (52/101)

6.1.1.16

Translation, ribosomal structure and biogenesis

Aminoacyl-tRNA biosynthesis Cysteine metabolism

GO:0004812|tRNA ligase activity|IEA; GO:0004817|cysteine-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006423|cysteinyl-tRNA aminoacylation|IEA; GO:0016874|ligase activity|IEA

ACL00003788

Histone H3.1 related cluster

95

2e-13

55% (20/36)

Chromatin structure and dynamics

GO:0000786|nucleosome|IEA; GO:0003677|DNA binding|IEA; GO:0005634|nucleus|IEA; GO:0005694|chromosome|IEA; GO:0006334|nucleosome assembly|IEA; GO:0007001|chromosome organization and biogenesis (sensu Eukaryota)|IEA

ACL00003789

F21A20.10; pentatricopeptide (PPR) repeat-containing protein

146

4e-09

41% (31/75)

ACL00003790

Betaine aldehyde dehydrogenase, putative related cluster

352

2e-32

35% (84/239)

Energy production and conversion

GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00003791

F9D16.270; high mobility group (HMG1/2) family protein

133

9e-08

37% (22/58)

ACL00003792

PTP1

Protein-tyrosine phosphatase 1 related cluster

365

3e-34

40% (81/198)

3.1.3.48

Signal transduction mechanisms

GO:0004721|phosphoprotein phosphatase activity|IEA; GO:0004725|protein tyrosine phosphatase activity|IEA; GO:0006470|protein amino acid dephosphorylation|IEA; GO:0016787|hydrolase activity|IEA

ACL00003793

Asparaginyl-tRNA synthetase related cluster

223

4e-18

58% (49/84)

Translation, ribosomal structure and biogenesis

Alanine and aspartate metabolism Aminoacyl-tRNA biosynthesis

GO:0003676|nucleic acid binding|IEA; GO:0004812|tRNA ligase activity|IEA; GO:0004816|asparagine-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0005737|cytoplasm|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006418|tRNA aminoacylation for protein translation|IEA; GO:0006421|asparaginyl-tRNA aminoacylation|IEA; GO:0016874|ligase activity|IEA

ACL00003794

WD-repeat protein An11 homolog related cluster

278

2e-24

51% (50/97)

General function prediction only

GO:0005737|cytoplasm|NR; GO:0007165|signal transduction|TAS

ACL00003795

Ornithine cyclodeaminase/mu-crystallin family protein related cluster

233

3e-19

37% (55/146)

Amino acid transport and metabolism

ACL00003796

MAP2K beta protein related cluster

177

8e-13

60% (33/55)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0004713|protein-tyrosine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00003798

26S proteasome regulatory subunit S2 related cluster

471

1e-46

57% (88/152)

Posttranslational modification, protein turnover, chaperones

Proteasome

GO:0000074|regulation of cell cycle|IEA; GO:0005488|binding|IEA; GO:0005829|cytosol|IEA

ACL00003799

unclassified

ACL00003800

unclassified

ACL00003801

LYAG

Lysosomal alpha-glucosidase precursor related cluster

269

4e-23

35% (69/197)

3.2.1.20

Carbohydrate transport and metabolism

GO:0004553|hydrolase activity, hydrolyzing O-glycosyl compounds|IEA; GO:0004558|alpha-glucosidase activity|IEA; GO:0004558|alpha-glucosidase activity|IMP; GO:0005764|lysosome|IEA; GO:0005764|lysosome|TAS; GO:0005975|carbohydrate metabolism|IEA; GO:0005980|glycogen catabolism|IMP; GO:0016787|hydrolase activity|IEA; GO:0016798|hydrolase activity, acting on glycosyl bonds|IEA

ACL00003802

multi-domain protein

149

1e-10

32% (35/107)

ACL00003803

SYN

Asparaginyl-tRNA synthetase related cluster

645

1e-66

59% (127/214)

6.1.1.22

Translation, ribosomal structure and biogenesis

Alanine and aspartate metabolism Aminoacyl-tRNA biosynthesis

GO:0003676|nucleic acid binding|IEA; GO:0004812|tRNA ligase activity|IEA; GO:0004815|aspartate-tRNA ligase activity|IEA; GO:0004816|asparagine-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0005737|cytoplasm|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006418|tRNA aminoacylation for protein translation|IEA; GO:0006421|asparaginyl-tRNA aminoacylation|IEA; GO:0006422|aspartyl-tRNA aminoacylation|IEA; GO:0016874|ligase activity|IEA

ACL00003805

YCGJ protein related cluster

281

2e-24

35% (64/179)

GO:0008168|methyltransferase activity|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA

ACL00003806

Unassigned protein

ACL00003807

Reverse transcriptase (RNA-dependent DNA polymerase)

144

3e-09

36% (35/95)

ACL00003808

CG1637

CG1637; CG1637 gene product from transcript CG1637-RA

251

1e-21

44% (55/124)

ACL00003809

unclassified

ACL00003810

BTB (POZ) domain containing 6 [Mus musculus] sp|Q8K2J9|BTB6_MOUSE BTB/POZ domain containing protein 6 gb|AAH31195.1| BTB (POZ) domain containing 6 [Mus musculus]

134

3e-07

32% (41/126)

ACL00003811

unclassified

ACL00003813

unclassified

ACL00003814

Putative WD40 repeat protein related cluster

91

1e-25

51% (17/33)

General function prediction only

ACL00003816

Putative RNA-binding protein related cluster

282

6e-25

42% (56/133)

General function prediction only

GO:0003723|RNA binding|IEA

ACL00003817

Unknown EST

118

9e-07

42% (20/47)

ACL00003818

unclassified

ACL00003819

Sec61a

SEC61, alpha subunit related cluster

207

3e-16

97% (41/42)

Intracellular trafficking, secretion, and vesicular transport

Protein export

GO:0006605|protein targeting|IEA; GO:0006810|transport|IEA; GO:0009306|protein secretion|IEA; GO:0015031|protein transport|IEA; GO:0015450|protein translocase activity|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA

ACL00003820

unclassified

ACL00003821

TPR repeat precursor related cluster

127

8e-07

32% (41/125)

General function prediction only

GO:0005488|binding|IEA

ACL00003822

unclassified

ACL00003823

Putative hydroxymethylglutaryl coenzyme A synthase related cluster

78

9e-15

73% (14/19)

2.3.3.10

Lipid transport and metabolism

Butanoate metabolism Synthesis and degradation of ketone bodies Valine, leucine and isoleucine degradation

GO:0004421|hydroxymethylglutaryl-CoA synthase activity|IEA; GO:0006084|acetyl-CoA metabolism|IEA

ACL00003824

Dhtkd1

2-oxoglutarate dehydrogenase E1 component related cluster

321

2e-29

53% (64/119)

Energy production and conversion

GO:0004591|oxoglutarate dehydrogenase (succinyl-transferring) activity|IEA; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016624|oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor|IEA

ACL00003825

unclassified

ACL00003826

FADS2

Delta-6 fatty acid desaturase related cluster

183

2e-13

48% (41/84)

1.14.19.3

GO:0005624|membrane fraction|TAS; GO:0005887|integral to plasma membrane|TAS; GO:0006633|fatty acid biosynthesis|IEA; GO:0006636|fatty acid desaturation|IEA; GO:0006636|fatty acid desaturation|TAS; GO:0008610|lipid biosynthesis|IEA; GO:0016020|membrane|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016717|oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water|IEA

ACL00003827

Nt5m

5'(3')-deoxyribonucleotidase, mitochondrial precursor related cluster

135

1e-07

26% (34/128)

GO:0000166|nucleotide binding|IEA; GO:0000287|magnesium ion binding|IEA; GO:0005739|mitochondrion|IEA; GO:0008253|5'-nucleotidase activity|IDA; GO:0009117|nucleotide metabolism|IEA; GO:0009120|deoxyribonucleoside metabolism|IC; GO:0016787|hydrolase activity|IEA

ACL00003830

26S protease regulatory subunit 6B homolog related cluster

254

1e-21

74% (53/71)

Posttranslational modification, protein turnover, chaperones

Proteasome

GO:0005524|ATP binding|IEA; GO:0005634|nucleus|IEA; GO:0005737|cytoplasm|IEA; GO:0005829|cytosol|IEA; GO:0016787|hydrolase activity|IEA; GO:0030163|protein catabolism|IEA

ACL00003831

Fbxw7

F-box/WD-repeat protein 7 related cluster

232

4e-19

40% (40/99)

General function prediction only

Neurodegenerative Disorders

GO:0005634|nucleus|IEA; GO:0006512|ubiquitin cycle|IEA

ACL00003832

Zmpste24

Zmpste24; zinc metalloproteinase, STE24 homolog (S. cerevisiae)

180

2e-13

36% (40/110)

ACL00003833

unclassified

ACL00003834

multi-domain protein

121

3e-07

50% (21/42)

ACL00003835

Cysteine protease, possible related cluster

164

3e-11

41% (30/72)

GO:0008233|peptidase activity|IEA

ACL00003836

unclassified

ACL00003837

Putative leucine-rich repeat protein related cluster

141

1e-08

47% (32/68)

Function unknown

ACL00003838

Unassigned protein

ACL00003839

unclassified

ACL00003840

Dpyd

Dihydropyrimidine dehydrogenase related cluster

390

2e-37

66% (77/116)

1.3.1.2

Pantothenate and CoA biosynthesis Pyrimidine metabolism beta-Alanine metabolism

GO:0004152|dihydroorotate dehydrogenase activity|IEA; GO:0004158|dihydroorotate oxidase activity|IEA; GO:0005489|electron transporter activity|IEA; GO:0005506|iron ion binding|IEA; GO:0005737|cytoplasm|IEA; GO:0006118|electron transport|IEA; GO:0006207|'de novo' pyrimidine base biosynthesis|IEA; GO:0015036|disulfide oxidoreductase activity|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0017113|dihydropyrimidine dehydrogenase (NADP+) activity|IEA

ACL00003841

unclassified

ACL00003842

GAS2 domain containing protein

85

9e-05

34% (24/70)

ACL00003843

VPS29

Vacuolar protein sorting 29 related cluster

555

1e-56

74% (98/131)

GO:0005554|molecular_function unknown|IEA; GO:0006810|transport|IEA; GO:0015031|protein transport|IEA; GO:0016787|hydrolase activity|IEA

ACL00003844

HPRP8BP

U5 snRNP-specific 40 kDa protein related cluster

121

4e-06

26% (35/130)

GO:0000398|nuclear mRNA splicing, via spliceosome|NAS; GO:0005732|small nucleolar ribonucleoprotein complex|NAS; GO:0008248|pre-mRNA splicing factor activity|NAS

ACL00003845

METK

S-adenosylmethionine synthetase related cluster

102

3e-13

100% (20/20)

2.5.1.6

Coenzyme transport and metabolism

GO:0000287|magnesium ion binding|IEA; GO:0004478|methionine adenosyltransferase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006730|one-carbon compound metabolism|IEA; GO:0016740|transferase activity|IEA

ACL00003846

unclassified

ACL00003847

unclassified

ACL00003848

unclassified

ACL00003849

unclassified

ACL00003850

Actin related protein 2 related cluster

423

1e-155

81% (80/98)

Cytoskeleton

GO:0005200|structural constituent of cytoskeleton|IEA; GO:0015629|actin cytoskeleton|IEA

ACL00003851

unclassified

ACL00003852

unclassified

ACL00003853

Putative alpha-galactosidase related cluster

225

2e-18

71% (42/59)

3.2.1.22

Galactose metabolism Globoside metabolism Glycerolipid metabolism Glycosphingolipid metabolism

GO:0004553|hydrolase activity, hydrolyzing O-glycosyl compounds|IEA; GO:0005975|carbohydrate metabolism|IEA

ACL00003855

PKD domain containing protein

102

2e-06

38% (15/39)

ACL00003856

unclassified

ACL00003857

Lignostilbene-alpha,beta-dioxygenase related cluster

206

4e-16

56% (33/58)

1.13.11.43

Secondary metabolites biosynthesis, transport and catabolism

GO:0016702|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|IEA

ACL00003858

MYC6.7; TFIIH basal transcription factor complex helicase XPB subunit, putative

429

7e-42

61% (78/126)

ACL00003859

Choline transporter protein 1 related cluster

139

4e-08

30% (42/138)

GO:0008152|metabolism|IEA; GO:0008415|acyltransferase activity|IEA

ACL00003860

ABC transporter AbcB1 related cluster

208

7e-55

37% (42/113)

Defense mechanisms

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0006810|transport|IEA; GO:0016021|integral to membrane|IEA; GO:0016887|ATPase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA; GO:0042626|ATPase activity, coupled to transmembrane movement of substances|IEA

ACL00003861

Putative odorant-binding protein A5 precursor related cluster

130

2e-07

27% (31/112)

ACL00003863

unclassified

ACL00003864

Protein kinase related cluster

382

4e-36

41% (71/173)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0004713|protein-tyrosine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00003865

unclassified

ACL00003866

PSN domain containing protein

81

1e-04

11% (5/45)

ACL00003867

Aldehyde dehydrogenase related cluster

297

1e-26

61% (55/89)

1.2.1.3

Energy production and conversion

Arginine and proline metabolism Ascorbate and aldarate metabolism Bile acid biosynthesis Butanoate metabolism Fatty acid metabolism Glycerolipid metabolism Glycolysis / Gluconeogenesis Histidine metabolism Limonene and pinene degradation Lysine degradation Propanoate metabolism Pyruvate metabolism Tryptophan metabolism Valine, leucine and isoleucine degradation beta-Alanine metabolism

GO:0004029|aldehyde dehydrogenase (NAD) activity|IEA; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00003868

unclassified

ACL00003869

unclassified

ACL00003871

unclassified

ACL00003872

Rpn2

Similar to ribophorin II related cluster

252

3e-21

37% (67/179)

GO:0004579|dolichyl-diphosphooligosaccharide-protein glycotransferase activity|IEA; GO:0005789|endoplasmic reticulum membrane|IEA; GO:0008250|oligosaccharyl transferase complex|IEA; GO:0018279|N-linked glycosylation via asparagine|IEA

ACL00003873

unclassified

ACL00003874

Unassigned protein

ACL00003875

METE

5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase related cluster

132

3e-70

67% (25/37)

2.1.1.14

Methionine metabolism

GO:0003871|5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity|IEA; GO:0008168|methyltransferase activity|IEA; GO:0009086|methionine biosynthesis|IEA; GO:0016740|transferase activity|IEA

ACL00003876

TyrKc domain containing protein

89

3e-05

29% (10/34)

ACL00003877

ARHGAP22

Rho GTPase activating protein 2 related cluster

152

7e-10

41% (29/70)

ACL00003879

Putative serine/threonine phosphatase related cluster

228

1e-18

39% (51/128)

Signal transduction mechanisms

GO:0003824|catalytic activity|IEA; GO:0004722|protein serine/threonine phosphatase activity|IEA; GO:0006470|protein amino acid dephosphorylation|IEA; GO:0008287|protein serine/threonine phosphatase complex|IEA

ACL00003880

Psmd12

Similar to proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12 related cluster

202

4e-39

50% (38/76)

Posttranslational modification, protein turnover, chaperones

Proteasome

ACL00003881

TT_ORF1 domain containing protein

127

7e-08

38% (26/68)

ACL00003882

Unassigned protein

ACL00003883

PCY2

Ethanolamine-phosphate cytidylyltransferase related cluster

171

4e-12

34% (32/92)

2.7.7.14

Aminophosphonate metabolism Glycerolipid metabolism

GO:0004306|ethanolamine-phosphate cytidylyltransferase activity|IEA; GO:0004306|ethanolamine-phosphate cytidylyltransferase activity|TAS; GO:0008372|cellular_component unknown|ND; GO:0008654|phospholipid biosynthesis|IEA; GO:0008654|phospholipid biosynthesis|TAS; GO:0009058|biosynthesis|IEA; GO:0016740|transferase activity|IEA; GO:0016779|nucleotidyltransferase activity|IEA

ACL00003884

unclassified

ACL00003885

RPA9

DNA-directed RNA polymerase I 13.1 kDa polypeptide related cluster

237

3e-19

42% (47/111)

2.7.7.6

Transcription

GO:0003677|DNA binding|IEA; GO:0003700|transcription factor activity|IEA; GO:0003899|DNA-directed RNA polymerase activity|IDA; GO:0003899|DNA-directed RNA polymerase activity|IEA; GO:0005634|nucleus|IEA; GO:0005736|DNA-directed RNA polymerase I complex|TAS; GO:0006350|transcription|IEA; GO:0006354|RNA elongation|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006360|transcription from Pol I promoter|IC; GO:0016740|transferase activity|IEA

ACL00003886

metal-dependent hydrolase

150

2e-09

27% (40/143)

General function prediction only

ACL00003888

TT_ORF1 domain containing protein

116

1e-06

35% (25/70)

ACL00003889

unclassified

ACL00003890

unclassified

ACL00003891

multi-domain protein

124

1e-07

20% (37/181)

ACL00003892

unclassified

ACL00003893

unclassified

ACL00003894

unclassified

ACL00003895

AAA domain containing protein

89

3e-05

40% (13/32)

ACL00003896

Methyl-accepting chemotaxis protein related cluster

152

7e-10

40% (30/75)

GO:0004871|signal transducer activity|IEA; GO:0005344|oxygen transporter activity|IEA; GO:0005506|iron ion binding|IEA; GO:0006810|transport|IEA; GO:0006935|chemotaxis|IEA; GO:0007165|signal transduction|IEA; GO:0016020|membrane|IEA

ACL00003897

citrate lyase beta chain [EC:4.1.3.6] [KO:K01644]

115

9e-06

36% (33/91)

4.1.3.6

Carbohydrate transport and metabolism

Citrate cycle (TCA cycle) Reductive carboxylate cycle (CO2 fixation)

ACL00003898

Protein c20orf4 homolog related cluster

270

2e-23

35% (54/153)

ACL00003899

HPCL2

2-hydroxyphytanoyl-CoA lyase related cluster

682

1e-70

48% (136/283)

4.1.-.-

GO:0000287|magnesium ion binding|IEA; GO:0005777|peroxisome|IEA; GO:0005777|peroxisome|TAS; GO:0006629|lipid metabolism|TAS; GO:0016829|lyase activity|IEA

ACL00003900

DTW domain containing protein

139

1e-09

22% (22/100)

ACL00003901

unclassified

ACL00003902

ATPO

ATP synthase oligomycin sensitivity conferral protein, mitochondrial precursor related cluster

176

9e-12

32% (54/168)

3.6.3.14

Energy production and conversion

ATP synthesis Oxidative phosphorylation

GO:0005739|mitochondrion|IEA; GO:0006754|ATP biosynthesis|IEA; GO:0015078|hydrogen ion transporter activity|IEA; GO:0015986|ATP synthesis coupled proton transport|IEA; GO:0015992|proton transport|IEA; GO:0016469|proton-transporting two-sector ATPase complex|IEA; GO:0016787|hydrolase activity|IEA; GO:0046933|hydrogen-transporting ATP synthase activity, rotational mechanism|IEA; GO:0046961|hydrogen-transporting ATPase activity, rotational mechanism|IEA

ACL00003903

Similar to prenylated SNARE protein related cluster

300

7e-27

41% (66/160)

ACL00003904

unclassified

ACL00003905

unclassified

ACL00003906

unclassified

ACL00003907

Unknown EST

100

7e-06

72% (18/25)

ACL00003908

Unassigned protein

132

1e-07

39% (29/73)

ACL00003909

SUCB

Succinyl-CoA ligase [GDP-forming] beta-chain, hydrogenosomal precursor related cluster

290

7e-26

59% (54/91)

6.2.1.4

Energy production and conversion

GO:0003824|catalytic activity|IEA; GO:0004776|succinate-CoA ligase (GDP-forming) activity|IEA; GO:0006099|tricarboxylic acid cycle|IEA; GO:0008152|metabolism|IEA; GO:0016874|ligase activity|IEA; GO:0042566|hydrogenosome|IEA

ACL00003910

unclassified

ACL00003911

Similar to Dictyostelium discoideum (Slime mold). MYOM protein related cluster

240

1e-19

40% (52/127)

GO:0005085|guanyl-nucleotide exchange factor activity|IEA; GO:0007242|intracellular signaling cascade|IEA

ACL00003912

LOC235497

LOC235497; similar to senescence downregulated leo1-like

178

1e-12

37% (39/104)

ACL00003913

GRK2

Glycerate kinase 2 related cluster

186

1e-13

44% (41/93)

2.7.1.31

Carbohydrate transport and metabolism

Glycerolipid metabolism Glycine, serine and threonine metabolism Glyoxylate and dicarboxylate metabolism

GO:0006468|protein amino acid phosphorylation|IEA; GO:0008887|glycerate kinase activity|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00003914

unclassified

ACL00003915

Similar to Dictyostelium discoideum (Slime mold). protein tyrosine kinase related cluster

230

6e-19

37% (50/132)

ACL00003916

unclassified

ACL00003917

Putative oxidoreductase related cluster

206

4e-16

52% (39/74)

Energy production and conversion

ACL00003918

FYRC domain containing protein

151

7e-11

28% (25/87)

ACL00003920

NUHM

NADH-ubiquinone oxidoreductase 24 kDa subunit, mitochondrial precursor related cluster

357

1e-33

66% (68/102)

1.6.5.3

Energy production and conversion

GO:0003954|NADH dehydrogenase activity|IEA; GO:0005739|mitochondrion|IEA; GO:0006120|mitochondrial electron transport, NADH to ubiquinone|IEA; GO:0008137|NADH dehydrogenase (ubiquinone) activity|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00003921

unclassified

ACL00003922

unclassified

ACL00003923

unclassified

ACL00003924

unclassified

ACL00003925

multi-domain protein

278

1e-25

42% (46/107)

ACL00003926

Diacylglycerol acyltransferase type 2B related cluster

780

4e-82

50% (148/291)

GO:0008415|acyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00003927

chlG

Chlorophyll synthetase related cluster

129

3e-07

88% (22/25)

2.5.1.62

Porphyrin and chlorophyll metabolism

GO:0016020|membrane|IEA; GO:0030494|bacteriochlorophyll biosynthesis|IEA

ACL00003928

AF-4 domain containing protein

113

4e-06

21% (43/203)

ACL00003929

KCTD9

KCTD9; potassium channel tetramerisation domain containing 9

151

2e-09

29% (47/157)

ACL00003930

Diacylglycerol acyltransferase type 2A related cluster

150

2e-09

27% (51/187)

GO:0008415|acyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00003931

multi-domain protein

125

2e-07

22% (56/244)

ACL00003932

Probable cytochrome b5 related cluster

218

4e-17

39% (57/146)

GO:0005792|microsome|IEA; GO:0006118|electron transport|IEA; GO:0016021|integral to membrane|IEA

ACL00003933

Probable short-chain dehydrogenase related cluster

252

2e-21

49% (45/91)

ACL00003934

Ttc1

Similar to tetratricopeptide repeat domain 1 related cluster

315

2e-28

37% (75/200)

General function prediction only

GO:0005488|binding|IEA

ACL00003938

CTR1-like protein kinase related cluster

95

4e-20

65% (15/23)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0004713|protein-tyrosine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00003939

HIS1

ATP phosphoribosyltransferase related cluster

71

2e-23

50% (17/34)

2.4.2.17

Amino acid transport and metabolism

Histidine metabolism

GO:0000105|histidine biosynthesis|IEA; GO:0000287|magnesium ion binding|IEA; GO:0003879|ATP phosphoribosyltransferase activity|IEA; GO:0016740|transferase activity|IEA; GO:0016757|transferase activity, transferring glycosyl groups|IEA

ACL00003940

Herpes_BLLF1 domain containing protein

111

7e-06

25% (52/203)

ACL00003941

CG5876

HEIX protein related cluster

195

2e-14

35% (54/152)

GO:0009234|menaquinone biosynthesis|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016740|transferase activity|IEA

ACL00003942

SAM domain containing protein

126

7e-08

36% (22/60)

ACL00003943

unclassified

ACL00003944

unclassified

ACL00003945

ydgJ

Oxidoreductase related cluster

57

8e-28

56% (9/16)

GO:0006118|electron transport|IEA; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00003946

Myo-inositol oxygenase related cluster

200

2e-15

48% (39/81)

GO:0016491|oxidoreductase activity|IEA; GO:0050113|inositol oxygenase activity|IEA

ACL00003947

rocE

Amino acid permease:permease for amino acids and related comp.. related cluster

156

1e-09

24% (84/349)

Amino acid transport and metabolism

GO:0005279|amino acid-polyamine transporter activity|IEA; GO:0006865|amino acid transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA

ACL00003948

Similar to Oryza sativa (Rice). glucose-6-phosphate dehydrogenase related cluster

584

8e-60

64% (109/170)

Carbohydrate transport and metabolism

GO:0004345|glucose-6-phosphate 1-dehydrogenase activity|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0006006|glucose metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00003949

unclassified

ACL00003950

unclassified

ACL00003951

EKI1

Ethanolamine kinase related cluster

257

4e-22

42% (56/133)

2.7.1.82

Cell wall/membrane/envelope biogenesis

Glycerolipid metabolism

GO:0004305|ethanolamine kinase activity|IDA; GO:0004305|ethanolamine kinase activity|IEA; GO:0005737|cytoplasm|NAS; GO:0006646|phosphatidylethanolamine biosynthesis|IDA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00003953

unclassified

ACL00003954

multi-domain protein

137

4e-09

45% (26/57)

ACL00003955

ACON

Aconitate hydratase, mitochondrial precursor related cluster

635

2e-65

60% (125/207)

4.2.1.3

GO:0003994|aconitate hydratase activity|IEA; GO:0003994|aconitate hydratase activity|NR; GO:0005506|iron ion binding|TAS; GO:0005739|mitochondrion|IEA; GO:0005739|mitochondrion|TAS; GO:0006091|generation of precursor metabolites and energy|TAS; GO:0006099|tricarboxylic acid cycle|IEA; GO:0006101|citrate metabolism|TAS; GO:0008152|metabolism|IEA; GO:0016829|lyase activity|IEA; GO:0016836|hydro-lyase activity|IEA

ACL00003956

NRC2

Serine/threonine-protein kinase nrc-2 related cluster

198

3e-15

64% (38/59)

2.7.1.37

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016740|transferase activity|IEA; GO:0030435|sporulation|IEA

ACL00003957

MYOM protein related cluster

145

1e-08

28% (40/142)

GO:0003774|motor activity|IEA; GO:0005524|ATP binding|IEA; GO:0016459|myosin|IEA

ACL00003958

Vitamin K-dependent gamma-carboxylase related cluster

336

9e-31

35% (74/207)

GO:0008488|gamma-glutamyl carboxylase activity|IEA; GO:0017187|peptidyl-glutamic acid carboxylation|IEA

ACL00003959

Unassigned protein

ACL00003960

unclassified

ACL00003961

unclassified

ACL00003962

Unassigned protein

ACL00003963

unclassified

ACL00003964

Protamine_P1 domain containing protein

113

5e-06

46% (26/56)

ACL00003965

CGI-94

CGI-94; comparative gene identification transcript 94

167

8e-12

33% (40/119)

ACL00003966

unclassified

ACL00003967

Unknown EST

63

1e-08

42% (11/26)

ACL00003968

LOC245347

Brain protein 44-like protein related cluster

177

8e-13

49% (35/71)

GO:0005554|molecular_function unknown|IEA

ACL00003969

Aminopeptidase related cluster

222

2e-17

34% (57/166)

General function prediction only

GO:0004177|aminopeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00003970

Adenylosuccinate lyase related cluster

192

2e-39

60% (36/60)

Nucleotide transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0004018|adenylosuccinate lyase activity|IEA; GO:0009152|purine ribonucleotide biosynthesis|IEA; GO:0016829|lyase activity|IEA

ACL00003971

LOC380711

GTPase activating protein Rap1-GAP related cluster

129

3e-07

41% (30/73)

GO:0005096|GTPase activator activity|IEA; GO:0007165|signal transduction|IEA

ACL00003972

unclassified

ACL00003974

EHD3

EH-domain containing protein 3 related cluster

427

3e-41

38% (92/240)

GO:0003676|nucleic acid binding|TAS; GO:0003924|GTPase activity|IEA; GO:0005509|calcium ion binding|IEA; GO:0005524|ATP binding|IEA; GO:0005525|GTP binding|IEA; GO:0005634|nucleus|TAS

ACL00003975

similar to dTDP-4-dehydrorhamnose reductase

743

8e-78

59% (136/229)

ACL00003976

Talin related cluster

167

3e-11

25% (50/195)

GO:0005856|cytoskeleton|IEA

ACL00003977

CLCN7

Chloride channel protein 7 related cluster

170

6e-12

35% (48/136)

GO:0005216|ion channel activity|IEA; GO:0005244|voltage-gated ion channel activity|IEA; GO:0005247|voltage-gated chloride channel activity|IEA; GO:0005254|chloride channel activity|TAS; GO:0005624|membrane fraction|NR; GO:0005887|integral to plasma membrane|NR; GO:0006810|transport|TAS; GO:0006811|ion transport|IEA; GO:0006821|chloride transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA

ACL00003978

Dynamin like protein related cluster

364

5e-34

60% (69/115)

General function prediction only

GO:0003924|GTPase activity|IEA; GO:0005525|GTP binding|IEA

ACL00003979

Slc39a7

Zinc transporter SLC39A7 related cluster

166

4e-11

43% (40/93)

GO:0006810|transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0030001|metal ion transport|IEA; GO:0046873|metal ion transporter activity|IEA

ACL00003980

Unassigned protein

141

2e-08

39% (39/99)

ACL00003981

unclassified

ACL00003982

Unassigned protein

ACL00003983

PDP2

[Pyruvate dehydrogenase [Lipoamide]]-phosphatase 2, mitochondrial precursor related cluster

179

1e-12

34% (47/136)

3.1.3.43

Signal transduction mechanisms

GO:0000287|magnesium ion binding|IEA; GO:0003824|catalytic activity|IEA; GO:0004721|phosphoprotein phosphatase activity|IEA; GO:0004722|protein serine/threonine phosphatase activity|IEA; GO:0004741|[pyruvate dehydrogenase (lipoamide)] phosphatase activity|IEA; GO:0005739|mitochondrion|IEA; GO:0006470|protein amino acid dephosphorylation|IEA; GO:0008287|protein serine/threonine phosphatase complex|IEA; GO:0016787|hydrolase activity|IEA

ACL00003984

unclassified

ACL00003985

unclassified

ACL00003986

CG4824

Bicaudal C protein related cluster

122

2e-06

43% (28/65)

GO:0003676|nucleic acid binding|IEA; GO:0003723|RNA binding|NAS; GO:0007319|negative regulation of oskar mRNA translation|TAS; GO:0009993|oogenesis (sensu Insecta)|IMP

ACL00003987

unclassified

ACL00003988

unclassified

ACL00003989

unclassified

ACL00003992

Unknown EST

50

3e-06

50% (6/12)

ACL00003993

unclassified

ACL00003995

Unassigned protein

125

2e-06

35% (42/118)

ACL00003996

unclassified

ACL00003997

Putative prolyl endopeptidase related cluster

670

2e-69

61% (120/196)

3.4.21.26

ACL00003998

Putative snRNP protein related cluster

477

3e-47

48% (100/206)

GO:0003676|nucleic acid binding|IEA; GO:0004386|helicase activity|IEA; GO:0005524|ATP binding|IEA; GO:0008026|ATP-dependent helicase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00003999

unclassified

ACL00004000

ASNS1

Asparagine synthetase [glutamine-hydrolyzing] 1 related cluster

974

1e-104

64% (185/289)

6.3.5.4

Amino acid transport and metabolism

GO:0004066|asparagine synthase (glutamine-hydrolyzing) activity|IEA; GO:0004066|asparagine synthase (glutamine-hydrolyzing) activity|IMP; GO:0005737|cytoplasm|IDA; GO:0006529|asparagine biosynthesis|IEA; GO:0006529|asparagine biosynthesis|TAS; GO:0006541|glutamine metabolism|IEA; GO:0008152|metabolism|IEA; GO:0016874|ligase activity|IEA

ACL00004001

unclassified

ACL00004002

unclassified

ACL00004003

unclassified

ACL00004004

Unknown EST

69

4e-06

62% (10/16)

ACL00004005

RVS161

Reduced viability upon starvation protein 161 related cluster

183

2e-13

33% (41/121)

GO:0005515|protein binding|IEA; GO:0005737|cytoplasm|IEA; GO:0005856|cytoskeleton|IEA; GO:0006897|endocytosis|IEA; GO:0006897|endocytosis|IMP; GO:0006970|response to osmotic stress|IMP; GO:0007121|bipolar bud site selection|IMP; GO:0008092|cytoskeletal protein binding|IPI; GO:0030479|actin cortical patch|IDA; GO:0045121|lipid raft|IDA

ACL00004007

Similar to protein phosphatase 4, regulatory subunit 1 related cluster

384

1e-36

48% (77/159)

GO:0005488|binding|IEA

ACL00004008

large fused protein of putative glutamine amidotransferase and glutamate carboxypeptidase

134

1e-07

53% (25/47)

General function prediction only

ACL00004009

ODP2

Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial precursor related cluster

322

4e-29

41% (66/158)

2.3.1.12

Energy production and conversion

GO:0004742|dihydrolipoyllysine-residue acetyltransferase activity|IEA; GO:0005515|protein binding|IEA; GO:0005739|mitochondrion|IEA; GO:0006096|glycolysis|IEA; GO:0008152|metabolism|IEA; GO:0008415|acyltransferase activity|IEA; GO:0016740|transferase activity|IEA; GO:0045254|pyruvate dehydrogenase complex|IEA

ACL00004010

putative carnitine/acylcarnitine translocase

Mitchondrial carnitine/acylcarnitine carrier protein CACL related cluster

164

3e-11

50% (32/64)

GO:0005215|transporter activity|IEA; GO:0005488|binding|IEA; GO:0005739|mitochondrion|IEA; GO:0005743|mitochondrial inner membrane|IEA; GO:0006810|transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0019866|inner membrane|IEA

ACL00004011

ABC transporter-like protein related cluster

263

4e-22

36% (65/176)

General function prediction only

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0016887|ATPase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

ACL00004012

unclassified

ACL00004013

GPDA

Glycerol-3-phosphate dehydrogenase [NAD+] related cluster

812

1e-85

51% (161/312)

1.1.1.8

Energy production and conversion

Glycerolipid metabolism

GO:0004367|glycerol-3-phosphate dehydrogenase (NAD+) activity|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0006072|glycerol-3-phosphate metabolism|IEA; GO:0009331|glycerol-3-phosphate dehydrogenase complex|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016614|oxidoreductase activity, acting on CH-OH group of donors|IEA

ACL00004014

GDP-4-keto-6-deoxy-D-mannose epimerase-reductase related cluster

336

3e-31

86% (58/67)

ACL00004015

Similar to WD domain, G-beta repeat containing protein data source:Pfam, source key:PF00400, evidence:ISS putative related cluster

192

4e-14

46% (39/83)

GO:0000151|ubiquitin ligase complex|IEA; GO:0004842|ubiquitin-protein ligase activity|IEA; GO:0016567|protein ubiquitination|IEA

ACL00004016

zf-UBP domain containing protein

115

1e-06

56% (17/30)

ACL00004017

Zip domain containing protein

120

3e-07

26% (21/78)

ACL00004018

ubiquitin-activating enzyme E1

204

1e-15

36% (52/141)

Coenzyme transport and metabolism

ACL00004019

multi-domain protein

125

1e-07

44% (35/78)

ACL00004020

multi-domain protein

101

9e-07

29% (17/57)

ACL00004021

unclassified

ACL00004022

UBP44

Ubiquitin carboxyl-terminal hydrolase 44 related cluster

201

1e-15

45% (37/81)

3.1.2.15

Posttranslational modification, protein turnover, chaperones

GO:0004197|cysteine-type endopeptidase activity|IEA; GO:0004221|ubiquitin thiolesterase activity|IEA; GO:0006511|ubiquitin-dependent protein catabolism|IEA; GO:0006512|ubiquitin cycle|IEA; GO:0008234|cysteine-type peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00004023

Alpha-amylase family protein related cluster

128

4e-07

36% (31/84)

GO:0004556|alpha-amylase activity|IEA; GO:0005975|carbohydrate metabolism|IEA

ACL00004024

unclassified

ACL00004025

unclassified

ACL00004026

unclassified

ACL00004027

unclassified

ACL00004028

unclassified

ACL00004029

unclassified

ACL00004030

unclassified

ACL00004031

Ras-related protein Rab7 related cluster

323

1e-29

45% (68/151)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00004032

Eukaryotic translation initiation factor 3 subunit 11 related cluster

273

6e-24

43% (55/127)

GO:0003743|translation initiation factor activity|IEA; GO:0005634|nucleus|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006413|translational initiation|IEA

ACL00004033

zinc finger-like [Oryza sativa (japonica cultivar-group)] dbj|BAD22971.1| zinc finger-like [Oryza sativa (japonica cultivar-group)] dbj|BAD23100.1| zinc finger-like [Oryza sativa (japonica cultivar-group)]

120

9e-06

54% (23/42)

ACL00004034

Tubulin beta-2 chain related cluster

431

3e-42

55% (78/141)

Cytoskeleton

GO:0003924|GTPase activity|IEA; GO:0005198|structural molecule activity|IEA; GO:0005525|GTP binding|IEA; GO:0005634|nucleus|IEA; GO:0005874|microtubule|IEA; GO:0007018|microtubule-based movement|IEA; GO:0045298|tubulin|IEA; GO:0046785|microtubule polymerization|IEA

ACL00004035

unclassified

ACL00004036

unclassified

ACL00004037

Glycine_acyl_tr domain containing protein

136

5e-09

32% (31/94)

ACL00004038

Protein KIAA1688 related cluster

269

3e-23

38% (64/166)

GO:0005856|cytoskeleton|IEA

ACL00004039

Putative ubiquitin-specific protein related cluster

77

4e-08

37% (12/32)

GO:0004197|cysteine-type endopeptidase activity|IEA; GO:0004221|ubiquitin thiolesterase activity|IEA; GO:0006511|ubiquitin-dependent protein catabolism|IEA

ACL00004040

similar to hlyA

127

6e-07

30% (29/96)

ACL00004041

unclassified

ACL00004042

unclassified

ACL00004043

unclassified

ACL00004045

unclassified

ACL00004046

unclassified

ACL00004047

lipoprotein, putative

134

8e-08

29% (43/147)

ACL00004048

unclassified

ACL00004049

Probable AMP-binding enzyme related cluster

199

2e-15

43% (42/96)

Lipid transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0008152|metabolism|IEA

ACL00004050

F27M3.19; oxidoreductase, 2OG-Fe(II) oxygenase family protein

137

2e-08

38% (37/97)

ACL00004051

unclassified

ACL00004052

TT_ORF1 domain containing protein

111

4e-06

45% (24/53)

ACL00004053

multi-domain protein

112

8e-08

68% (17/25)

ACL00004054

unclassified

ACL00004055

unclassified

ACL00004056

unclassified

ACL00004057

unclassified

ACL00004058

wbnF

Nucleotide sugar epimerase related cluster

229

1e-18

43% (47/108)

5.1.3.-

GO:0003824|catalytic activity|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0009225|nucleotide-sugar metabolism|IEA; GO:0016857|racemase and epimerase activity, acting on carbohydrates and derivatives|IEA

ACL00004060

Poly(ADP)-ribose polymerase related cluster

195

9e-15

42% (36/85)

2.4.2.30

GO:0003677|DNA binding|IEA; GO:0003950|NAD+ ADP-ribosyltransferase activity|IEA; GO:0005622|intracellular|IEA; GO:0005634|nucleus|IEA; GO:0006259|DNA metabolism|IEA; GO:0006471|protein amino acid ADP-ribosylation|IEA; GO:0016740|transferase activity|IEA; GO:0016757|transferase activity, transferring glycosyl groups|IEA

ACL00004061

unclassified

ACL00004062

[R] COG3044 Predicted ATPase of the ABC class

136

3e-08

38% (31/81)

General function prediction only

ACL00004063

unclassified

ACL00004064

CDK-activating kinase related cluster

641

2e-66

68% (118/172)

2.7.1.37

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00004065

unclassified

ACL00004066

QinA related cluster

1029

1e-111

74% (185/249)

GO:0006120|mitochondrial electron transport, NADH to ubiquinone|IEA; GO:0008137|NADH dehydrogenase (ubiquinone) activity|IEA

ACL00004067

unclassified

ACL00004068

CD2 domain containing protein

117

4e-07

28% (25/88)

ACL00004069

unclassified

ACL00004071

unclassified

ACL00004072

Hdac1

Histone deacetylase 1 related cluster

341

8e-32

95% (62/65)

GO:0000118|histone deacetylase complex|TAS; GO:0003700|transcription factor activity|TAS; GO:0004407|histone deacetylase activity|IEA; GO:0004407|histone deacetylase activity|TAS; GO:0005634|nucleus|IEA; GO:0005634|nucleus|TAS; GO:0005737|cytoplasm|TAS; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006916|anti-apoptosis|TAS; GO:0008134|transcription factor binding|TAS; GO:0016568|chromatin modification|IEA; GO:0016568|chromatin modification|TAS; GO:0016575|histone deacetylation|IEA; GO:0016787|hydrolase activity|IEA

ACL00004073

unclassified

ACL00004074

Unassigned protein

ACL00004075

rplC

50S ribosomal protein L3 related cluster

146

3e-09

54% (28/51)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003723|RNA binding|IEA; GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0019843|rRNA binding|IEA

ACL00004076

TT_ORF1 domain containing protein

109

6e-06

48% (23/47)

ACL00004077

Arsenite transport subunit A related cluster

729

3e-76

54% (143/261)

3.6.3.16

GO:0005524|ATP binding|IEA; GO:0006820|anion transport|IEA; GO:0016020|membrane|IEA

ACL00004079

unclassified

ACL00004080

TMS_TDE domain containing protein

418

1e-41

36% (72/199)

ACL00004081

multi-domain protein

180

4e-14

54% (31/57)

ACL00004082

A1pp domain containing protein

223

4e-19

41% (38/91)

ACL00004083

Ammonium transporter AmtA related cluster

534

6e-54

68% (99/144)

GO:0006810|transport|IEA; GO:0008519|ammonium transporter activity|IEA; GO:0016020|membrane|IEA

ACL00004084

Cytochome b5 related cluster

247

6e-21

56% (42/75)

ACL00004085

Leucine zipper & ICAT homologous protein LZIC related cluster

470

3e-46

51% (99/191)

GO:0007275|development|IEA; GO:0008013|beta-catenin binding|IEA

ACL00004086

unclassified

ACL00004087

multi-domain protein

118

5e-07

36% (28/77)

ACL00004088

unclassified

ACL00004089

Putative translation initiation factor IF-2, 35582-30916 related cluster

567

1e-57

57% (109/190)

Translation, ribosomal structure and biogenesis

GO:0003743|translation initiation factor activity|IEA; GO:0005525|GTP binding|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006413|translational initiation|IEA

ACL00004090

unclassified

ACL00004091

USP5

Putative ubiquitin isopeptidase T related cluster

573

4e-58

41% (119/285)

3.1.2.15

Posttranslational modification, protein turnover, chaperones

ACL00004092

unclassified

ACL00004093

T16B14.3; zinc finger (C3HC4-type RING finger) family protein

138

6e-08

45% (28/62)

ACL00004094

Sorting nexin-like protein related cluster

163

4e-11

47% (34/72)

GO:0007242|intracellular signaling cascade|IEA

ACL00004095

unclassified

ACL00004096

unclassified

ACL00004097

T23O

Tryptophan 2,3-dioxygenase related cluster

235

4e-19

37% (53/141)

1.13.11.11

Tryptophan metabolism

GO:0004833|tryptophan 2,3-dioxygenase activity|IEA; GO:0004833|tryptophan 2,3-dioxygenase activity|TAS; GO:0006568|tryptophan metabolism|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016702|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|IEA; GO:0042133|neurotransmitter metabolism|NR

ACL00004099

unclassified

ACL00004100

Putative beta-subunit of K+ channels related cluster

392

1e-37

57% (75/131)

GO:0005216|ion channel activity|IEA; GO:0005249|voltage-gated potassium channel activity|IEA; GO:0006813|potassium ion transport|IEA; GO:0016021|integral to membrane|IEA

ACL00004101

unclassified

ACL00004102

galE

Similar to Bacillus subtilis. UDP-glucose 4-epimerase related cluster

695

2e-72

62% (135/215)

5.1.3.2

Cell wall/membrane/envelope biogenesis

Galactose metabolism Nucleotide sugars metabolism

GO:0003824|catalytic activity|IEA; GO:0003978|UDP-glucose 4-epimerase activity|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0006012|galactose metabolism|IEA; GO:0009225|nucleotide-sugar metabolism|IEA; GO:0016857|racemase and epimerase activity, acting on carbohydrates and derivatives|IEA

ACL00004103

DM6 domain containing protein

97

9e-06

21% (23/106)

ACL00004104

RAB1B

Small GTP-binding protein RAB1 related cluster

126

2e-28

50% (22/44)

General function prediction only

GO:0000160|two-component signal transduction system (phosphorelay)|IEA; GO:0003677|DNA binding|IEA; GO:0005525|GTP binding|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00004105

unclassified

ACL00004106

unclassified

ACL00004107

appr-1-p processing enzyme family domain protein

290

1e-25

64% (55/85)

ACL00004108

DKFZP434G2226

Putative kinesin-like protein related cluster

179

5e-13

34% (41/120)

Cytoskeleton

GO:0003774|motor activity|IEA; GO:0005524|ATP binding|IEA; GO:0005875|microtubule associated complex|IEA

ACL00004110

Cathepsin L-like related cluster

363

5e-34

45% (82/180)

GO:0004197|cysteine-type endopeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008233|peptidase activity|IEA; GO:0008234|cysteine-type peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00004111

unclassified

ACL00004112

Related to neurofibromin related cluster

190

5e-14

37% (42/113)

ACL00004113

S_TKc domain containing protein

105

3e-07

38% (18/47)

ACL00004114

unclassified

ACL00004115

KDG3

Putative diacylglycerol kinase 3 related cluster

42

3e-12

45% (9/20)

2.7.1.107

Glycerolipid metabolism Phosphatidylinositol signaling system Phospholipid degradation

GO:0004143|diacylglycerol kinase activity|IEA; GO:0005509|calcium ion binding|IEA; GO:0007205|protein kinase C activation|IEA; GO:0007242|intracellular signaling cascade|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA; GO:0019992|diacylglycerol binding|IEA

ACL00004116

multi-domain protein

159

1e-11

43% (32/73)

ACL00004117

unclassified

ACL00004118

LENG9

LENG9; leukocyte receptor cluster (LRC) member 9

165

4e-11

46% (42/91)

ACL00004119

unclassified

ACL00004120

L-methionine-alpha-deamino-gamma-mercaptomethane- lyase related cluster

50

2e-33

53% (7/13)

4.4.1.11

Amino acid transport and metabolism

Selenoamino acid metabolism

GO:0006520|amino acid metabolism|IEA; GO:0016829|lyase activity|IEA; GO:0018826|methionine gamma-lyase activity|IEA

ACL00004121

PROF domain containing protein

84

1e-04

30% (20/66)

ACL00004122

ZC3HDC3

Zinc finger CCCH type domain containing protein 3 related cluster

128

6e-07

41% (24/58)

GO:0003676|nucleic acid binding|IEA

ACL00004123

TT_ORF1 domain containing protein

113

3e-06

39% (27/69)

ACL00004124

AMPL

Cytosol aminopeptidase related cluster

466

4e-46

57% (94/163)

3.4.11.1

Amino acid transport and metabolism

GO:0000287|magnesium ion binding|IEA; GO:0000287|magnesium ion binding|NAS; GO:0004177|aminopeptidase activity|IEA; GO:0004178|leucyl aminopeptidase activity|IEA; GO:0004178|leucyl aminopeptidase activity|NAS; GO:0005622|intracellular|IEA; GO:0005737|cytoplasm|IEA; GO:0005737|cytoplasm|NAS; GO:0006508|proteolysis and peptidolysis|IEA; GO:0006508|proteolysis and peptidolysis|NAS; GO:0008270|zinc ion binding|NAS; GO:0016787|hydrolase activity|IEA; GO:0016804|prolyl aminopeptidase activity|IEA; GO:0016804|prolyl aminopeptidase activity|NAS; GO:0019538|protein metabolism|IEA; GO:0030145|manganese ion binding|IEA; GO:0030145|manganese ion binding|NAS

ACL00004125

SART-1 domain containing protein

127

4e-08

25% (32/127)

ACL00004126

unclassified

ACL00004129

NEC1

Neuroendocrine convertase 1 precursor related cluster

266

6e-23

37% (66/178)

3.4.21.93

GO:0004252|serine-type endopeptidase activity|IEA; GO:0004285|proprotein convertase 1 activity|IEA; GO:0004289|subtilase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0006508|proteolysis and peptidolysis|TAS; GO:0007267|cell-cell signaling|TAS; GO:0008152|metabolism|TAS; GO:0016787|hydrolase activity|IEA

ACL00004130

unclassified

ACL00004131

2-oxoacid_dh domain containing protein

136

5e-09

32% (28/87)

ACL00004132

Dnajb6

DnaJ homolog subfamily B member 6 related cluster

278

2e-24

48% (53/109)

Posttranslational modification, protein turnover, chaperones

GO:0006457|protein folding|IEA; GO:0006986|response to unfolded protein|NAS; GO:0008372|cellular_component unknown|ND; GO:0051082|unfolded protein binding|IEA

ACL00004133

multi-domain protein

122

2e-07

36% (36/98)

ACL00004134

SH2 domain containing protein

112

1e-07

30% (19/63)

ACL00004135

RSP5

Ubiquitin--protein ligase RSP5 related cluster

208

2e-16

36% (45/123)

6.3.2.-

Posttranslational modification, protein turnover, chaperones

Ubiquitin mediated proteolysis

GO:0000151|ubiquitin ligase complex|IDA; GO:0000209|protein polyubiquitination|IDA; GO:0004842|ubiquitin-protein ligase activity|IDA; GO:0004842|ubiquitin-protein ligase activity|IEA; GO:0005622|intracellular|IEA; GO:0005739|mitochondrion|IDA; GO:0006333|chromatin assembly or disassembly|IMP; GO:0006350|transcription|TAS; GO:0006464|protein modification|IEA; GO:0006512|ubiquitin cycle|IEA; GO:0006513|protein monoubiquitination|IDA; GO:0006897|endocytosis|TAS; GO:0016874|ligase activity|IEA

ACL00004136

Ras-related protein RGP2 related cluster

291

1e-25

40% (63/156)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00004137

unclassified

ACL00004138

unclassified

ACL00004140

unclassified

ACL00004141

CSK22

Casein kinase II, alpha chain 2 (CK II) related cluster

264

5e-98

74% (49/66)

2.7.1.37

Circadian rhythm

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016740|transferase activity|IEA

ACL00004142

Clcn3

Chloride channel protein 3 related cluster

276

7e-24

34% (64/188)

GO:0005247|voltage-gated chloride channel activity|IEA; GO:0005254|chloride channel activity|ISS; GO:0005769|early endosome|ISS; GO:0005770|late endosome|ISS; GO:0005794|Golgi apparatus|ISS; GO:0006821|chloride transport|IEA; GO:0006885|regulation of pH|ISS; GO:0009986|cell surface|ISS; GO:0012506|vesicle membrane|ISS; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|ISS; GO:0030165|PDZ domain binding|ISS; GO:0042803|protein homodimerization activity|ISS; GO:0046982|protein heterodimerization activity|ISS; GO:0048388|endosomal lumen acidification|ISS

ACL00004143

unclassified

ACL00004144

RTPR

Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase related cluster

261

4e-22

39% (59/150)

1.17.4.2

GO:0003824|catalytic activity|IEA; GO:0006260|DNA replication|IEA; GO:0008998|ribonucleoside-triphosphate reductase activity|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00004145

unclassified

ACL00004146

U1 small nuclear ribonucleoprotein A related cluster

347

2e-32

67% (62/92)

GO:0003723|RNA binding|IEA; GO:0005634|nucleus|IEA; GO:0005634|nucleus|TAS; GO:0005681|spliceosome complex|IEA; GO:0007539|primary sex determination, soma|NAS; GO:0008248|pre-mRNA splicing factor activity|TAS; GO:0008380|RNA splicing|TAS; GO:0009993|oogenesis (sensu Insecta)|TAS; GO:0019099|female germ-line sex determination|NAS; GO:0030529|ribonucleoprotein complex|IEA; GO:0030532|small nuclear ribonucleoprotein complex|IDA

ACL00004147

unclassified

ACL00004148

unclassified

ACL00004149

unclassified

ACL00004152

Putative purple acid phosphatase related cluster

146

3e-28

44% (28/63)

GO:0016787|hydrolase activity|IEA

ACL00004153

T29E15.2; metal-dependent phosphohydrolase HD domain-containing protein

300

3e-26

47% (59/124)

General function prediction only

ACL00004154

Putative isocitrate dehydrogenase related cluster

69

1e-42

52% (11/21)

GO:0004449|isocitrate dehydrogenase (NAD+) activity|IEA; GO:0005739|mitochondrion|IEA; GO:0006099|tricarboxylic acid cycle|IEA; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00004155

unclassified

ACL00004156

Retinal short-chain dehydrogenase/reductase 4 precursor related cluster

241

5e-20

36% (54/148)

GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00004157

unclassified

ACL00004158

Signal recognition particle receptor beta subunit-like protein related cluster

327

9e-30

37% (76/202)

GO:0004872|receptor activity|IEA

ACL00004159

unclassified

ACL00004160

multi-domain protein

120

4e-07

17% (25/140)

ACL00004161

Stress-inducible protein STI1 homolog related cluster

335

2e-30

42% (74/174)

GO:0005488|binding|IEA

ACL00004162

Fatty acyl-CoA synthetase related cluster

431

5e-42

46% (85/181)

Lipid transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0004467|long-chain-fatty-acid-CoA ligase activity|IEA; GO:0008152|metabolism|IEA; GO:0016874|ligase activity|IEA

ACL00004163

multi-domain protein

134

2e-08

22% (61/273)

ACL00004164

Ras-related protein Rap-1 related cluster

653

2e-67

90% (129/142)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00004165

Adrm1

Adrm1; adhesion regulating molecule 1

164

3e-11

50% (35/69)

ACL00004166

unclassified

ACL00004168

Putative elongation factor Tu related cluster

382

2e-36

55% (77/139)

3.6.5.3

Translation, ribosomal structure and biogenesis

GO:0003746|translation elongation factor activity|IEA; GO:0005525|GTP binding|IEA; GO:0006412|protein biosynthesis|IEA

ACL00004171

CD2 domain containing protein

120

1e-07

32% (24/75)

ACL00004172

LOC382868

Ribosomal protein L23a related cluster

461

1e-45

74% (86/116)

Translation, ribosomal structure and biogenesis

GO:0003723|RNA binding|IEA; GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00004173

unclassified

ACL00004174

unclassified

ACL00004175

Polyubiquitin related cluster

174

2e-12

46% (39/83)

ACL00004176

unclassified

ACL00004177

unclassified

ACL00004178

unclassified

ACL00004179

Inosine-uridine preferring nucleoside hydrolase family protein related cluster

170

1e-11

31% (54/171)

Nucleotide transport and metabolism

Nicotinate and nicotinamide metabolism Purine metabolism

GO:0016787|hydrolase activity|IEA

ACL00004180

STIP1

STIP1; stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein)

158

3e-10

38% (36/93)

ACL00004181

unclassified

ACL00004186

Unassigned protein

ACL00004190

Calcineurin B related cluster

306

2e-27

37% (64/171)

GO:0005509|calcium ion binding|IEA

ACL00004193

ACOC

Aconitate hydratase, cytoplasmic related cluster

1523

1e-168

64% (294/457)

4.2.1.3

Citrate cycle (TCA cycle) Glyoxylate and dicarboxylate metabolism Reductive carboxylate cycle (CO2 fixation)

GO:0003723|RNA binding|IEA; GO:0003994|aconitate hydratase activity|IEA; GO:0005506|iron ion binding|IEA; GO:0006097|glyoxylate cycle|IEA; GO:0008152|metabolism|IEA; GO:0016829|lyase activity|IEA; GO:0016836|hydro-lyase activity|IEA

ACL00004196

act-2

Actin, cytoplasmic 2 related cluster

1834

0.0

96% (349/361)

Cytoskeleton

GO:0005200|structural constituent of cytoskeleton|NR

ACL00004198

Ribosomal protein S15 related cluster

480

1e-47

71% (92/128)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0015935|small ribosomal subunit|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00004199

ENO

Enolase related cluster

1599

1e-176

71% (310/431)

4.2.1.11

Carbohydrate transport and metabolism

Glycolysis / Gluconeogenesis Phenylalanine, tyrosine and tryptophan biosynthesis

GO:0000015|phosphopyruvate hydratase complex|IEA; GO:0000287|magnesium ion binding|IEA; GO:0004634|phosphopyruvate hydratase activity|IEA; GO:0006096|glycolysis|IEA; GO:0016829|lyase activity|IEA

ACL00004201

PPCK

Phosphoenolpyruvate carboxykinase [GTP] related cluster

1609

1e-178

57% (303/523)

4.1.1.32

Energy production and conversion

Citrate cycle (TCA cycle) Pyruvate metabolism

GO:0004611|phosphoenolpyruvate carboxykinase activity|IEA; GO:0004613|phosphoenolpyruvate carboxykinase (GTP) activity|IEA; GO:0005525|GTP binding|IEA; GO:0006094|gluconeogenesis|IEA; GO:0016829|lyase activity|IEA; GO:0016831|carboxy-lyase activity|IEA

ACL00004202

Herpes_gp2 domain containing protein

115

3e-06

18% (42/230)

ACL00004203

T12P18.15; proline-rich family protein

206

9e-16

34% (55/161)

ACL00004204

Cysteine proteinase related cluster

1155

1e-125

80% (216/270)

Posttranslational modification, protein turnover, chaperones

GO:0004197|cysteine-type endopeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008233|peptidase activity|IEA; GO:0008234|cysteine-type peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00004207

multi-domain protein

133

2e-08

19% (57/286)

ACL00004208

40S ribosomal protein S3a related cluster

804

8e-85

66% (153/230)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00004214

CYPH

Peptidyl-prolyl cis-trans isomerase related cluster

618

2e-63

73% (114/155)

5.2.1.8

Posttranslational modification, protein turnover, chaperones

GO:0003755|peptidyl-prolyl cis-trans isomerase activity|IEA; GO:0006457|protein folding|IEA; GO:0016853|isomerase activity|IEA

ACL00004216

40S ribosomal protein S25-2 related cluster

268

4e-23

69% (50/72)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA

ACL00004222

unclassified

ACL00004224

unclassified

ACL00004225

unclassified

ACL00004226

APC10

Anaphase promoting complex subunit 10 related cluster

464

7e-46

52% (78/149)

Ubiquitin mediated proteolysis

GO:0005515|protein binding|IEA; GO:0005515|protein binding|NAS; GO:0005680|anaphase-promoting complex|IEA; GO:0005680|anaphase-promoting complex|NAS; GO:0006512|ubiquitin cycle|IEA; GO:0007049|cell cycle|IEA; GO:0007067|mitosis|IEA; GO:0007067|mitosis|NAS; GO:0030071|regulation of mitotic metaphase/anaphase transition|IEA

ACL00004227

ABC transporter AbcG16 related cluster

200

6e-15

26% (51/193)

Defense mechanisms

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0016887|ATPase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

ACL00004228

Unknown EST

58

6e-06

36% (16/44)

ACL00004229

unclassified

ACL00004230

unclassified

ACL00004231

Putative membrane protein-putative a permease related cluster

195

1e-14

32% (33/102)

General function prediction only

ACL00004232

Putative histidine kinase related cluster

217

2e-17

45% (45/100)

GO:0000155|two-component sensor molecule activity|IEA; GO:0000156|two-component response regulator activity|IEA; GO:0000160|two-component signal transduction system (phosphorelay)|IEA; GO:0003677|DNA binding|IEA; GO:0005524|ATP binding|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0007165|signal transduction|IEA; GO:0007600|sensory perception|IEA; GO:0016020|membrane|IEA; GO:0016301|kinase activity|IEA; GO:0016310|phosphorylation|IEA; GO:0016740|transferase activity|IEA; GO:0016772|transferase activity, transferring phosphorus-containing groups|IEA

ACL00004233

RABGAP1

Rab6 GTPase activating protein related cluster

230

1e-18

31% (48/152)

General function prediction only

ACL00004234

unclassified

ACL00004235

SNF2/SWI2 family global transcription factor related cluster

157

2e-10

38% (38/100)

GO:0000151|ubiquitin ligase complex|IEA; GO:0003676|nucleic acid binding|IEA; GO:0003677|DNA binding|IEA; GO:0004386|helicase activity|IEA; GO:0004842|ubiquitin-protein ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0008270|zinc ion binding|IEA; GO:0016567|protein ubiquitination|IEA

ACL00004236

rab5c

Similar to RAB5C, member RAS oncogene family related cluster

165

5e-27

83% (30/36)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00004237

Putative RING zinc finger protein related cluster

333

2e-30

63% (55/86)

Posttranslational modification, protein turnover, chaperones

GO:0000151|ubiquitin ligase complex|IEA; GO:0004842|ubiquitin-protein ligase activity|IEA; GO:0008270|zinc ion binding|IEA; GO:0016567|protein ubiquitination|IEA

ACL00004239

Unknown EST

84

1e-09

69% (16/23)

ACL00004240

unclassified

ACL00004242

unclassified

ACL00004243

Unassigned protein

145

4e-09

47% (33/69)

ACL00004244

Reverse transcriptase related cluster

139

1e-07

28% (40/141)

GO:0003676|nucleic acid binding|IEA; GO:0003723|RNA binding|IEA; GO:0003964|RNA-directed DNA polymerase activity|IEA; GO:0005634|nucleus|IEA; GO:0006278|RNA-dependent DNA replication|IEA; GO:0008270|zinc ion binding|IEA; GO:0016740|transferase activity|IEA

ACL00004245

unclassified

ACL00004246

unclassified

ACL00004247

unclassified

ACL00004248

unclassified

ACL00004249

YCII domain containing protein

189

3e-15

37% (31/82)

ACL00004250

Atp-dependent rna helicase related cluster

319

3e-29

57% (72/125)

GO:0003676|nucleic acid binding|IEA; GO:0004386|helicase activity|IEA; GO:0005524|ATP binding|IEA; GO:0008026|ATP-dependent helicase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00004251

multi-domain protein

122

8e-08

51% (25/49)

ACL00004252

unclassified

ACL00004253

unclassified

ACL00004254

HTH_DTXR domain containing protein

88

8e-05

29% (17/57)

ACL00004255

multi-domain protein

121

4e-07

50% (23/46)

ACL00004257

Unassigned protein

181

1e-12

33% (50/150)

ACL00004260

unclassified

ACL00004261

Unassigned protein

134

3e-07

27% (43/156)

ACL00004262

T20L15.50; oxidoreductase, 2OG-Fe(II) oxygenase family

128

8e-07

46% (36/78)

ACL00004263

LOC151194

Hepatocellular carcinoma-associated antigen HCA557b related cluster

60

8e-10

34% (23/66)

ACL00004264

unclassified

ACL00004265

unclassified

ACL00004266

Autophagocytosis protein AUT1-like related cluster

438

9e-43

59% (86/145)

ACL00004267

Alpha-galactosidase related cluster

140

8e-34

41% (31/74)

3.2.1.22

Galactose metabolism Globoside metabolism Glycerolipid metabolism Glycosphingolipid metabolism

GO:0004553|hydrolase activity, hydrolyzing O-glycosyl compounds|IEA; GO:0005975|carbohydrate metabolism|IEA

ACL00004268

CYDX

Cysteine dioxygenase type I related cluster

189

8e-14

29% (46/155)

1.13.11.20

Cysteine metabolism Taurine and hypotaurine metabolism

GO:0005489|electron transporter activity|NR; GO:0005506|iron ion binding|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016702|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|IEA; GO:0017172|cysteine dioxygenase activity|IEA; GO:0046439|L-cysteine metabolism|IEA

ACL00004269

unclassified

ACL00004270

Unassigned protein

ACL00004271

unclassified

ACL00004272

unclassified

ACL00004273

unclassified

ACL00004274

unclassified

ACL00004275

PRA1 domain containing protein

170

8e-13

29% (38/130)

ACL00004276

[P] COG0530 Ca2+/Na+ antiporter

135

3e-08

35% (31/88)

Inorganic ion transport and metabolism

ACL00004279

unclassified

ACL00004280

unclassified

ACL00004281

Probable O-methyltransferase related cluster

181

6e-13

36% (47/128)

General function prediction only

GO:0008168|methyltransferase activity|IEA; GO:0008171|O-methyltransferase activity|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00004282

unclassified

ACL00004283

Peroxisomal membrane protein PMP30B related cluster

138

1e-07

26% (39/145)

GO:0005777|peroxisome|IEA; GO:0005778|peroxisomal membrane|IEA; GO:0016020|membrane|IEA; GO:0016559|peroxisome division|IEA

ACL00004284

unclassified

ACL00004285

unclassified

ACL00004286

unclassified

ACL00004287

unclassified

ACL00004288

Eukaryotic translation initiation factor 4C related cluster

299

1e-26

64% (57/88)

Translation, ribosomal structure and biogenesis

GO:0003723|RNA binding|IEA; GO:0003743|translation initiation factor activity|IEA; GO:0006413|translational initiation|IEA

ACL00004289

unclassified

ACL00004290

PB1 domain containing protein

91

3e-05

31% (25/80)

ACL00004291

unclassified

ACL00004292

Ruvbl1

RuvB-like 1 related cluster

262

1e-22

58% (56/95)

Wnt signaling pathway

GO:0000166|nucleotide binding|IEA; GO:0003678|DNA helicase activity|IDA; GO:0004386|helicase activity|IEA; GO:0005524|ATP binding|IEA; GO:0005634|nucleus|IDA; GO:0005634|nucleus|IEA; GO:0006310|DNA recombination|IEA; GO:0006350|transcription|IEA; GO:0006357|regulation of transcription from Pol II promoter|TAS; GO:0007283|spermatogenesis|TAS; GO:0008722|DNA helicase IV activity|IEA; GO:0016787|hydrolase activity|IEA; GO:0016887|ATPase activity|IDA; GO:0017111|nucleoside-triphosphatase activity|IEA; GO:0035267|TIP60 histone acetyltransferase complex|IDA

ACL00004293

Unassigned protein

ACL00004295

unclassified

ACL00004296

unclassified

ACL00004297

unclassified

ACL00004298

Prkag2

Prkag2; protein kinase, AMP-activated, gamma 2 non-catalytic subunit

123

2e-06

23% (39/168)

ACL00004299

multi-domain protein

167

9e-13

43% (40/91)

ACL00004300

KEX2

Furin-like prohormone convertase related cluster

92

1e-37

48% (17/35)

3.4.21.61

GO:0004252|serine-type endopeptidase activity|IEA; GO:0004289|subtilase activity|IEA; GO:0004714|transmembrane receptor protein tyrosine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway|IEA; GO:0008233|peptidase activity|IEA; GO:0016020|membrane|IEA; GO:0016787|hydrolase activity|IEA

ACL00004302

Ankyrin repeat domain protein 28 related cluster

153

9e-10

37% (40/108)

General function prediction only

ACL00004304

Rfc3

Activator 1 38 kDa subunit related cluster

572

3e-58

57% (110/191)

GO:0000166|nucleotide binding|IEA; GO:0003677|DNA binding|IEA; GO:0003887|DNA-directed DNA polymerase activity|NR; GO:0005634|nucleus|IEA; GO:0005660|delta-DNA polymerase cofactor complex|TAS; GO:0005663|DNA replication factor C complex|IEA; GO:0005663|DNA replication factor C complex|TAS; GO:0006260|DNA replication|IEA; GO:0006271|DNA strand elongation|TAS; GO:0008047|enzyme activator activity|NR; GO:0017111|nucleoside-triphosphatase activity|IEA

ACL00004305

unclassified

ACL00004306

unclassified

ACL00004307

Similar to Arabidopsis thaliana (Mouse-ear cress). cell division cycle protein 23-like protein related cluster

338

3e-31

46% (65/141)

GO:0000910|cytokinesis|IEA; GO:0005488|binding|IEA; GO:0005680|anaphase-promoting complex|IEA; GO:0030071|regulation of mitotic metaphase/anaphase transition|IEA

ACL00004310

F5J6.4; phosphoglycerate/bisphosphoglycerate mutase family protein

210

2e-16

34% (59/171)

ACL00004311

Similar to WD domain, G-beta repeat containing protein data source:Pfam, source key:PF00400, evidence:ISS putative related cluster

182

4e-13

63% (38/60)

GO:0000151|ubiquitin ligase complex|IEA; GO:0004842|ubiquitin-protein ligase activity|IEA; GO:0016567|protein ubiquitination|IEA

ACL00004312

Splicing factor RSZ33 related cluster

150

3e-09

36% (32/87)

GO:0003676|nucleic acid binding|IEA; GO:0003723|RNA binding|IEA

ACL00004313

unclassified

ACL00004314

unclassified

ACL00004315

Unassigned protein

ACL00004317

Endomembrane protein EMP70 precusor isolog related cluster

588

4e-60

54% (112/204)

GO:0005215|transporter activity|IEA; GO:0006810|transport|IEA; GO:0016021|integral to membrane|IEA

ACL00004318

Extracellular protein, putative related cluster

118

7e-06

29% (36/124)

General function prediction only

GO:0004866|endopeptidase inhibitor activity|IEA

ACL00004319

unclassified

ACL00004320

Unknown EST

111

2e-06

50% (20/40)

ACL00004321

TT_ORF1 domain containing protein

108

1e-05

37% (30/80)

ACL00004322

multi-domain protein

135

1e-08

24% (42/174)

ACL00004323

LOC54499

Membrane protein related cluster

312

5e-28

38% (66/173)

ACL00004324

GatB/Yqey domain protein related cluster

200

5e-15

33% (48/144)

ACL00004325

Unassigned protein

198

6e-15

34% (46/135)

ACL00004326

Egfl4

Multiple EGF-like-domain protein 4 related cluster

125

3e-06

29% (31/104)

GO:0004872|receptor activity|IEA; GO:0005198|structural molecule activity|IEA; GO:0005509|calcium ion binding|IEA; GO:0007275|development|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA

ACL00004327

Ard1

Similar to N-acetyltransferase ARD1 homolog related cluster

529

3e-53

65% (102/156)

2.3.1.-

General function prediction only

Alkaloid biosynthesis II Benzoate degradation via CoA ligation Butanoate metabolism Ethylbenzene degradation Glycerolipid metabolism Histidine metabolism Limonene and pinene degradation Lysine biosynthesis Lysine degradation Phenylalanine metabolism Tyrosine metabolism Valine, leucine and isoleucine degradation

GO:0005515|protein binding|IPI; GO:0005737|cytoplasm|IDA; GO:0008080|N-acetyltransferase activity|IDA; GO:0008080|N-acetyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00004328

hemB

Delta-aminolevulinic acid dehydratase related cluster

391

2e-37

61% (83/136)

4.2.1.24

Coenzyme transport and metabolism

Porphyrin and chlorophyll metabolism

GO:0004655|porphobilinogen synthase activity|IEA; GO:0006779|porphyrin biosynthesis|IEA; GO:0006783|heme biosynthesis|IEA; GO:0016829|lyase activity|IEA

ACL00004329

Putative methyltransferase, S-adenosyl-L-methionine (SAM)-MTase protein related cluster

151

3e-09

27% (47/168)

GO:0008168|methyltransferase activity|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00004330

SERC

Phosphoserine aminotransferase related cluster

527

4e-53

55% (102/184)

2.6.1.52

Glycine, serine and threonine metabolism Vitamin B6 metabolism

GO:0004648|phosphoserine transaminase activity|IEA; GO:0006564|L-serine biosynthesis|IEA; GO:0008152|metabolism|IEA; GO:0008483|transaminase activity|IEA; GO:0008615|pyridoxine biosynthesis|IEA; GO:0016740|transferase activity|IEA

ACL00004331

unclassified

ACL00004332

Acyl-CoA oxidase related cluster

163

9e-11

42% (30/70)

GO:0003997|acyl-CoA oxidase activity|IEA; GO:0005777|peroxisome|IEA; GO:0006118|electron transport|IEA; GO:0006635|fatty acid beta-oxidation|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00004333

PPI1

Peptidyl-prolyl cis-trans isomerase ppi1 related cluster

360

6e-34

64% (70/109)

5.2.1.8

Posttranslational modification, protein turnover, chaperones

GO:0003755|peptidyl-prolyl cis-trans isomerase activity|IEA; GO:0006457|protein folding|IEA; GO:0016853|isomerase activity|IEA

ACL00004334

Glutathione S-transferase related cluster

132

3e-07

27% (43/156)

GO:0016740|transferase activity|IEA

ACL00004335

unclassified

ACL00004337

TyrKc domain containing protein

103

5e-07

35% (12/34)

ACL00004338

Putative calcium binding transcriptional regulatory protein related cluster

135

6e-08

49% (27/55)

GO:0003677|DNA binding|IEA; GO:0006350|transcription|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA

ACL00004339

Unknown EST

74

2e-06

56% (13/23)

ACL00004340

Cyclic GMP-binding protein C related cluster

368

2e-34

32% (70/215)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0004713|protein-tyrosine kinase activity|IEA; GO:0005085|guanyl-nucleotide exchange factor activity|IEA; GO:0005524|ATP binding|IEA; GO:0005525|GTP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0007242|intracellular signaling cascade|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00004341

unclassified

ACL00004342

Putative WD-40 repeat protein related cluster

139

4e-08

30% (37/120)

ACL00004343

F3I3.20; ubiquitin family protein

187

2e-13

56% (35/62)

ACL00004344

CBS domain protein related cluster

125

1e-06

29% (34/117)

ACL00004345

unclassified

ACL00004346

ABC transporter AbcG1 related cluster

194

2e-14

31% (39/124)

Defense mechanisms

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0016887|ATPase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

ACL00004347

Unassigned protein

193

3e-14

43% (39/89)

ACL00004348

unclassified

ACL00004350

unclassified

ACL00004351

multi-domain protein

115

2e-06

19% (33/172)

ACL00004352

unclassified

ACL00004353

unclassified

ACL00004356

Actin-related protein 2 related cluster

124

3e-06

25% (50/193)

GO:0003774|motor activity|IEA; GO:0005200|structural constituent of cytoskeleton|IEA; GO:0005884|actin filament|IEA; GO:0015629|actin cytoskeleton|IEA

ACL00004357

Unassigned protein

ACL00004358

Herpes_gp2 domain containing protein

117

1e-06

20% (40/193)

ACL00004359

unclassified

ACL00004360

multi-domain protein

133

1e-08

28% (35/122)

ACL00004361

Protein kinase related cluster

149

3e-09

30% (49/163)

GO:0016301|kinase activity|IEA

ACL00004362

PBP domain containing protein

122

2e-07

32% (24/74)

ACL00004363

Nos2

Neuronal nitric oxide synthase related cluster

260

7e-22

29% (69/233)

1.14.13.39

Arginine and proline metabolism

GO:0004517|nitric-oxide synthase activity|IEA; GO:0005489|electron transporter activity|IEA; GO:0005515|protein binding|IEA; GO:0006118|electron transport|IEA; GO:0006809|nitric oxide biosynthesis|IEA; GO:0010181|FMN binding|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00004364

Unassigned protein

ACL00004365

unclassified

ACL00004367

unclassified

ACL00004368

unclassified

ACL00004369

unclassified

ACL00004371

unclassified

ACL00004372

unclassified

ACL00004374

sppA

Endopeptidase IV related cluster

281

9e-25

44% (65/146)

3.4.21.-

GO:0006465|signal peptide processing|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008233|peptidase activity|IEA; GO:0008462|endopeptidase Clp activity|IEA; GO:0009003|signal peptidase activity|IEA; GO:0016021|integral to membrane|IEA

ACL00004375

pif1

DNA repair and recombination protein pif1, mitochondrial precursor related cluster

199

5e-15

40% (51/126)

GO:0000166|nucleotide binding|IEA; GO:0000723|telomere maintenance|IGI; GO:0003677|DNA binding|IEA; GO:0004386|helicase activity|IEA; GO:0005524|ATP binding|IEA; GO:0005634|nucleus|IGI; GO:0005739|mitochondrion|IEA; GO:0005739|mitochondrion|IGI; GO:0006260|DNA replication|TAS; GO:0006281|DNA repair|IEA; GO:0006281|DNA repair|IMP; GO:0006310|DNA recombination|IEA; GO:0006310|DNA recombination|IGI; GO:0007001|chromosome organization and biogenesis (sensu Eukaryota)|IGI; GO:0008094|DNA-dependent ATPase activity|IMP; GO:0017111|nucleoside-triphosphatase activity|IEA; GO:0043141|ATP-dependent 5' to 3' DNA helicase activity|IDA

ACL00004376

Similarity to tyrosine phosphatase related cluster

196

1e-14

30% (48/157)

Signal transduction mechanisms

ACL00004377

multi-domain protein

146

5e-10

19% (46/233)

ACL00004378

Unassigned protein

ACL00004379

GTP-binding protein related cluster

166

2e-11

40% (40/100)

General function prediction only

GO:0000160|two-component signal transduction system (phosphorelay)|IEA; GO:0003677|DNA binding|IEA; GO:0005525|GTP binding|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00004380

ADPP

ADP-ribose pyrophosphatase related cluster

228

1e-18

42% (48/114)

3.6.1.13

Nucleotide transport and metabolism

GO:0000287|magnesium ion binding|IEA; GO:0016787|hydrolase activity|IEA; GO:0047631|ADP-ribose diphosphatase activity|IEA

ACL00004381

Herpes_BLLF1 domain containing protein

111

6e-06

24% (55/228)

ACL00004382

Unassigned protein

ACL00004383

unclassified

ACL00004384

putative methyltransferase

204

7e-16

46% (47/102)

ACL00004385

unclassified

ACL00004387

Putative clathrin assembly protein related cluster

394

1e-37

56% (72/127)

Intracellular trafficking, secretion, and vesicular transport

GO:0006886|intracellular protein transport|IEA; GO:0030125|clathrin vesicle coat|IEA

ACL00004388

unclassified

ACL00004389

LIMS2

LIM-like protein 2A related cluster

178

9e-13

31% (40/129)

GO:0008270|zinc ion binding|IEA

ACL00004390

FKBP4

FK506-binding protein 4 related cluster

268

4e-23

33% (59/177)

5.2.1.8

GO:0003755|peptidyl-prolyl cis-trans isomerase activity|IEA; GO:0005488|binding|IEA; GO:0005634|nucleus|IEA; GO:0006457|protein folding|IEA; GO:0016853|isomerase activity|IEA

ACL00004391

Unassigned protein

ACL00004392

unclassified

ACL00004393

unclassified

ACL00004394

unclassified

ACL00004395

Putative actin interacting protein related cluster

252

2e-21

59% (46/77)

GO:0006118|electron transport|IEA

ACL00004396

unclassified

ACL00004397

RNA helicase related cluster

438

6e-43

46% (96/207)

GO:0003676|nucleic acid binding|IEA; GO:0004386|helicase activity|IEA; GO:0005524|ATP binding|IEA; GO:0008026|ATP-dependent helicase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00004398

Cysteine proteinase related cluster

431

3e-42

58% (86/146)

GO:0004197|cysteine-type endopeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008233|peptidase activity|IEA; GO:0008234|cysteine-type peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00004399

Unassigned protein

ACL00004400

Putative mRNA capping enzyme subunit related cluster

153

1e-09

27% (47/173)

GO:0004651|polynucleotide 5'-phosphatase activity|IEA; GO:0005634|nucleus|IEA; GO:0006370|mRNA capping|IEA; GO:0016787|hydrolase activity|IEA

ACL00004401

CG3425

Alcohol dehydrogenase 8 related cluster

449

4e-44

57% (89/155)

1.1.1.1

Energy production and conversion

Bile acid biosynthesis Fatty acid metabolism Glycerolipid metabolism Glycolysis / Gluconeogenesis Tyrosine metabolism

GO:0005506|iron ion binding|IEA; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00004402

Acetyltransferase-like protein related cluster

130

2e-07

48% (26/54)

GO:0008080|N-acetyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00004403

Ribosome biogenesis protein Brix related cluster

700

6e-73

53% (121/228)

Translation, ribosomal structure and biogenesis

GO:0005554|molecular_function unknown|ND; GO:0005634|nucleus|IEA; GO:0007046|ribosome biogenesis|IEA

ACL00004404

Similar to putative mitochondrial rna splicing protein related cluster

164

3e-11

43% (35/80)

GO:0016020|membrane|IEA; GO:0030001|metal ion transport|IEA; GO:0046873|metal ion transporter activity|IEA

ACL00004405

60S ribosomal protein L4 related cluster

588

6e-60

49% (122/246)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00004406

Putative 60S ribosomal protein related cluster

268

2e-23

58% (49/84)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00004407

unclassified

ACL00004408

Profilins IA/IB related cluster

213

6e-17

63% (49/77)

ACL00004409

F5E19.140; GCN5-related N-acetyltransferase (GNAT) family

216

2e-17

36% (43/118)

ACL00004410

Ras-related protein Rab7 related cluster

434

4e-42

51% (88/172)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00004411

TT_ORF1 domain containing protein

113

3e-06

44% (26/58)

ACL00004412

UbiA domain containing protein

133

1e-08

23% (56/237)

ACL00004414

Ribosomal protein L related cluster

133

1e-07

73% (25/34)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00004415

Subtilisin-like serine proteinase related cluster

249

4e-21

90% (49/54)

3.4.21.-

Posttranslational modification, protein turnover, chaperones

GO:0004252|serine-type endopeptidase activity|IEA; GO:0004289|subtilase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA; GO:0042802|protein self binding|IEA; GO:0043086|negative regulation of enzyme activity|IEA

ACL00004416

CBS domain protein related cluster

179

1e-12

29% (49/168)

General function prediction only

ACL00004417

unclassified

ACL00004418

Unknown EST

120

6e-07

63% (24/38)

ACL00004419

UCR6

Ubiquinol-cytochrome C reductase complex 14 kDa protein related cluster

122

2e-06

38% (23/59)

1.10.2.2

GO:0005739|mitochondrion|IEA; GO:0005746|mitochondrial electron transport chain|IEA; GO:0006118|electron transport|IEA; GO:0006122|mitochondrial electron transport, ubiquinol to cytochrome c|IEA; GO:0008121|ubiquinol-cytochrome-c reductase activity|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0019866|inner membrane|IEA

ACL00004420

unclassified

ACL00004421

unclassified

ACL00004422

unclassified

ACL00004423

unclassified

ACL00004424

unclassified

ACL00004425

Polyubiquitin related cluster

924

4e-99

96% (185/191)

ACL00004426

unclassified

ACL00004427

unclassified

ACL00004428

Mitochondrial phosphate carrier protein related cluster

42

8e-11

35% (7/20)

GO:0005315|inorganic phosphate transporter activity|IDA; GO:0005488|binding|IEA; GO:0005739|mitochondrion|IDA; GO:0005739|mitochondrion|IEA; GO:0005740|mitochondrial membrane|IDA; GO:0005743|mitochondrial inner membrane|IEA; GO:0006810|transport|IEA; GO:0006817|phosphate transport|IDA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0019866|inner membrane|IEA

ACL00004429

Rpl37a

Ribosomal protein L37A related cluster

166

2e-11

48% (27/56)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00004430

Alternative oxidase related cluster

148

2e-09

51% (27/52)

GO:0005739|mitochondrion|IEA; GO:0005740|mitochondrial membrane|IEA; GO:0005746|mitochondrial electron transport chain|IEA; GO:0007585|respiratory gaseous exchange|IEA; GO:0016021|integral to membrane|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0019866|inner membrane|IEA

ACL00004431

unclassified

ACL00004432

unclassified

ACL00004433

rps-5

40S ribosomal protein S5 related cluster

149

1e-09

100% (31/31)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0015935|small ribosomal subunit|IEA

ACL00004434

unclassified

ACL00004435

PI3K2

Phosphatidylinositol 3-kinase 2 related cluster

115

4e-77

77% (21/27)

2.7.1.137

GO:0004428|inositol or phosphatidylinositol kinase activity|IEA; GO:0005942|phosphoinositide 3-kinase complex|IEA; GO:0016301|kinase activity|IEA; GO:0016303|phosphatidylinositol 3-kinase activity|IEA; GO:0016740|transferase activity|IEA; GO:0016773|phosphotransferase activity, alcohol group as acceptor|IEA

ACL00004436

DM6 domain containing protein

95

2e-05

30% (25/81)

ACL00004437

unclassified

ACL00004438

ABC transporter AbcH.1 related cluster

533

9e-54

67% (106/157)

Defense mechanisms

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0016887|ATPase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

ACL00004439

unclassified

ACL00004440

unclassified

ACL00004441

unclassified

ACL00004442

Nubp1

Nucleotide-binding protein 1 related cluster

922

1e-98

69% (170/243)

GO:0005524|ATP binding|IEA; GO:0005554|molecular_function unknown|IEA

ACL00004443

unclassified

ACL00004444

Rab2

Ras-related protein Rab-2-B related cluster

418

2e-40

54% (85/157)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00004446

unclassified

ACL00004447

RPL36

60S ribosomal protein L36 related cluster

209

3e-16

47% (46/97)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0003735|structural constituent of ribosome|NAS; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0005842|cytosolic large ribosomal subunit (sensu Eukaryota)|NAS; GO:0006412|protein biosynthesis|IEA; GO:0006412|protein biosynthesis|NAS

ACL00004448

Unknown EST

207

2e-19

79% (39/49)

ACL00004449

unclassified

ACL00004450

unclassified

ACL00004451

Unassigned protein

ACL00004452

unclassified

ACL00004453

Similar to Dictyostelium discoideum (Slime mold). phosphatidylinositol 3-kinase 3 related cluster

480

1e-47

48% (91/187)

GO:0004428|inositol or phosphatidylinositol kinase activity|IEA; GO:0005942|phosphoinositide 3-kinase complex|IEA; GO:0016301|kinase activity|IEA; GO:0016303|phosphatidylinositol 3-kinase activity|IEA; GO:0016773|phosphotransferase activity, alcohol group as acceptor|IEA

ACL00004454

DNAJA2

DnaJ homolog subfamily A member 2 related cluster

297

1e-26

44% (61/138)

Posttranslational modification, protein turnover, chaperones

GO:0000074|regulation of cell cycle|TAS; GO:0000080|G1 phase of mitotic cell cycle|NR; GO:0006457|protein folding|IEA; GO:0008284|positive regulation of cell proliferation|TAS; GO:0016020|membrane|IEA; GO:0051082|unfolded protein binding|IEA

ACL00004455

Unassigned protein

141

2e-24

60% (27/45)

ACL00004456

4F5 domain containing protein

182

1e-14

62% (37/59)

ACL00004457

NADH dehoydrogenase related cluster

208

2e-16

62% (34/54)

1.6.5.3 1.6.99.3

Oxidative phosphorylation

GO:0003954|NADH dehydrogenase activity|IEA; GO:0005739|mitochondrion|IEA; GO:0006118|electron transport|IEA; GO:0008137|NADH dehydrogenase (ubiquinone) activity|IEA

ACL00004459

Ras-related protein Rab7 related cluster

51

4e-59

83% (10/12)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00004460

Putative purple acid phosphatase related cluster

304

2e-27

44% (62/139)

GO:0016787|hydrolase activity|IEA

ACL00004461

multi-domain protein

121

1e-08

34% (23/67)

ACL00004462

multi-domain protein

127

7e-08

21% (35/166)

ACL00004463

Ubiquitin related cluster

309

4e-28

95% (61/64)

Posttranslational modification, protein turnover, chaperones

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00004464

Endoglucanase E precursor related cluster

327

1e-29

35% (79/224)

GO:0003824|catalytic activity|IEA

ACL00004465

Histone H2A related cluster

384

3e-36

69% (79/113)

Chromatin structure and dynamics

GO:0000786|nucleosome|IEA; GO:0003677|DNA binding|IEA; GO:0005634|nucleus|IEA; GO:0005694|chromosome|IEA; GO:0006334|nucleosome assembly|IEA; GO:0007001|chromosome organization and biogenesis (sensu Eukaryota)|IEA

ACL00004466

unclassified

ACL00004467

Herpes_DNAp_acc domain containing protein

115

2e-06

24% (25/101)

ACL00004468

Cyclophilin, putative related cluster

415

2e-40

61% (77/125)

Posttranslational modification, protein turnover, chaperones

GO:0003755|peptidyl-prolyl cis-trans isomerase activity|IEA; GO:0006457|protein folding|IEA; GO:0016853|isomerase activity|IEA

ACL00004470

HMG domain containing protein

105

7e-07

63% (19/30)

ACL00004471

Putative SNAP25 homologous protein SNAP30 related cluster

125

2e-06

33% (28/84)

GO:0006810|transport|IEA; GO:0015031|protein transport|IEA; GO:0016020|membrane|IEA

ACL00004472

CBS domain protein related cluster

179

1e-12

29% (49/168)

General function prediction only

ACL00004474

unclassified

ACL00004475

unclassified

ACL00004476

F24B9.26; lactoylglutathione lyase family protein / glyoxalase I family protein

122

3e-06

40% (28/69)

Amino acid transport and metabolism

ACL00004477

unclassified

ACL00004478

unclassified

ACL00004480

Cysteine proteinase CPW2 related cluster

544

3e-55

70% (100/142)

GO:0004197|cysteine-type endopeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008234|cysteine-type peptidase activity|IEA

ACL00004481

unclassified

ACL00004482

unclassified

ACL00004483

multi-domain protein

121

4e-07

57% (26/45)

ACL00004484

Aldehyde reductase related cluster

278

2e-24

52% (58/110)

General function prediction only

ACL00004485

Shoot regeneration-related mitogen activated protein kinase kinase kinase related cluster

389

4e-37

48% (79/163)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00004486

unclassified

ACL00004487

unclassified

ACL00004488

unclassified

ACL00004489

unclassified

ACL00004490

CG8385

ADP-ribosylation factor related cluster

92

1e-20

53% (16/30)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00004491

unclassified

ACL00004492

HPCL2

2-hydroxyphytanoyl-CoA lyase related cluster

360

5e-34

60% (66/109)

4.1.-.-

GO:0000287|magnesium ion binding|IEA; GO:0005777|peroxisome|IEA; GO:0005777|peroxisome|TAS; GO:0006629|lipid metabolism|TAS; GO:0016829|lyase activity|IEA

ACL00004493

unclassified

ACL00004494

multi-domain protein

117

1e-06

23% (51/219)

ACL00004495

unclassified

ACL00004496

GAL11 domain containing protein

109

7e-06

21% (36/169)

ACL00004497

DAGKa domain containing protein

120

8e-09

35% (18/51)

ACL00004498

Nucleotide binding protein 2 related cluster

268

1e-55

59% (44/74)

ACL00004499

unclassified

ACL00004501

unclassified

ACL00004502

unclassified

ACL00004503

unclassified

ACL00004504

unclassified

ACL00004505

MSF1 domain containing protein

163

3e-12

36% (29/79)

ACL00004506

unclassified

ACL00004507

rab32

Similar to RAB32, member RAS oncogene family related cluster

261

1e-50

57% (55/96)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00004508

Sensor kinase related cluster

162

6e-11

33% (42/126)

2.7.3.-

GO:0000155|two-component sensor molecule activity|IEA; GO:0000156|two-component response regulator activity|IEA; GO:0000160|two-component signal transduction system (phosphorelay)|IEA; GO:0003677|DNA binding|IEA; GO:0004871|signal transducer activity|IEA; GO:0005524|ATP binding|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0007165|signal transduction|IEA; GO:0007600|sensory perception|IEA; GO:0016020|membrane|IEA; GO:0016301|kinase activity|IEA; GO:0016310|phosphorylation|IEA; GO:0016740|transferase activity|IEA; GO:0016772|transferase activity, transferring phosphorus-containing groups|IEA

ACL00004509

Unknown EST

61

4e-31

64% (11/17)

ACL00004510

unclassified

ACL00004511

Unassigned protein

ACL00004512

unclassified

ACL00004513

unclassified

ACL00004514

Protein kinase, putative related cluster

352

9e-33

45% (69/153)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0004713|protein-tyrosine kinase activity|IEA; GO:0004871|signal transducer activity|IEA; GO:0005524|ATP binding|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0007165|signal transduction|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00004515

LOC268695

Ribosomal protein L27a related cluster

510

3e-51

72% (93/128)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00004516

unclassified

ACL00004517

UCR7

Probable ubiquinol-cytochrome C reductase complex 14 kDa protein related cluster

188

4e-14

43% (39/89)

1.10.2.2

Oxidative phosphorylation

GO:0005739|mitochondrion|IEA; GO:0005746|mitochondrial electron transport chain|IEA; GO:0006118|electron transport|IEA; GO:0006122|mitochondrial electron transport, ubiquinol to cytochrome c|IEA; GO:0008121|ubiquinol-cytochrome-c reductase activity|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0019866|inner membrane|IEA

ACL00004518

CIT1

Citrate synthase related cluster

583

2e-59

62% (109/175)

2.3.3.1

Energy production and conversion

Citrate cycle (TCA cycle) Glyoxylate and dicarboxylate metabolism

GO:0004108|citrate (Si)-synthase activity|IEA; GO:0005737|cytoplasm|IEA; GO:0006092|main pathways of carbohydrate metabolism|IEA; GO:0006099|tricarboxylic acid cycle|IEA; GO:0016740|transferase activity|IEA; GO:0046912|transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer|IEA

ACL00004519

unclassified

ACL00004520

Unknown EST

71

2e-07

44% (13/29)

ACL00004522

Subtilisin-like serine proteinase related cluster

906

9e-97

70% (175/250)

3.4.21.-

Posttranslational modification, protein turnover, chaperones

GO:0004252|serine-type endopeptidase activity|IEA; GO:0004289|subtilase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA; GO:0042802|protein self binding|IEA; GO:0043086|negative regulation of enzyme activity|IEA

ACL00004523

AAA ATPase superfamily related cluster

583

2e-59

54% (123/227)

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

ACL00004524

unclassified

ACL00004525

unclassified

ACL00004526

Cytochrome-b5 reductase-like protein related cluster

496

2e-49

50% (97/191)

ACL00004527

Endoglucanase E precursor related cluster

226

3e-18

35% (57/162)

GO:0003824|catalytic activity|IEA

ACL00004528

Ribosomal protein L37A related cluster

163

4e-11

50% (27/54)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00004529

unclassified

ACL00004530

unclassified

ACL00004531

unclassified

ACL00004532

GTA1

Glutathione S-transferase alpha M14 related cluster

230

2e-18

39% (68/171)

2.5.1.18

GO:0004364|glutathione transferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00004533

Subtilisin-like serine proteinase related cluster

100

6e-33

47% (23/48)

Posttranslational modification, protein turnover, chaperones

GO:0004252|serine-type endopeptidase activity|IEA; GO:0004289|subtilase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA; GO:0042802|protein self binding|IEA; GO:0043086|negative regulation of enzyme activity|IEA

ACL00004534

unclassified

ACL00004535

S10_plectin domain containing protein

129

2e-08

60% (21/35)

ACL00004536

unclassified

ACL00004537

3-hydroxyisobutyrate dehydrogenase related cluster

286

2e-25

70% (54/77)

1.1.1.31

Lipid transport and metabolism

Valine, leucine and isoleucine degradation

GO:0004616|phosphogluconate dehydrogenase (decarboxylating) activity|IEA; GO:0006098|pentose-phosphate shunt|IEA; GO:0008442|3-hydroxyisobutyrate dehydrogenase activity|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00004538

unclassified

ACL00004539

Cyclic phosphodiesterase - like protein related cluster

123

2e-06

27% (28/102)

ACL00004540

PPIH

Peptidyl-prolyl cis-trans isomerase H related cluster

635

1e-65

75% (117/154)

5.2.1.8

Posttranslational modification, protein turnover, chaperones

GO:0000398|nuclear mRNA splicing, via spliceosome|IEA; GO:0003755|peptidyl-prolyl cis-trans isomerase activity|IEA; GO:0005634|nucleus|IEA; GO:0005681|spliceosome complex|IEA; GO:0005681|spliceosome complex|TAS; GO:0006397|mRNA processing|IEA; GO:0006457|protein folding|IEA; GO:0006457|protein folding|TAS; GO:0006461|protein complex assembly|TAS; GO:0006608|snRNP protein-nucleus import|TAS; GO:0016018|cyclosporin A binding|TAS; GO:0016853|isomerase activity|IEA; GO:0051082|unfolded protein binding|IEA

ACL00004541

unclassified

ACL00004542

Unassigned protein

161

6e-11

35% (34/95)

ACL00004543

Histone H4 related cluster

57

1e-36

100% (11/11)

Chromatin structure and dynamics

GO:0000786|nucleosome|IEA; GO:0003677|DNA binding|IEA; GO:0005634|nucleus|IEA; GO:0005694|chromosome|IEA; GO:0006334|nucleosome assembly|IEA; GO:0007001|chromosome organization and biogenesis (sensu Eukaryota)|IEA

ACL00004544

hsp70

Heat-shock protein 70 1 related cluster

265

5e-89

80% (51/63)

GO:0005524|ATP binding|IEA; GO:0006457|protein folding|IEA; GO:0006986|response to unfolded protein|IEA; GO:0051082|unfolded protein binding|IEA

ACL00004545

[K] COG1813 Predicted transcription factor, homolog of eukaryotic MBF1

79

4e-11

53% (17/32)

Transcription

ACL00004546

F6F3.4; ORMDL family protein

312

6e-28

42% (60/141)

ACL00004547

FKBP3

FK506-binding protein 3 related cluster

353

6e-33

66% (73/110)

5.2.1.8

GO:0003755|peptidyl-prolyl cis-trans isomerase activity|IEA; GO:0004872|receptor activity|TAS; GO:0005528|FK506 binding|TAS; GO:0005634|nucleus|IEA; GO:0006457|protein folding|IEA; GO:0016853|isomerase activity|IEA

ACL00004548

Unknown EST

143

2e-10

85% (24/28)

ACL00004550

MOBKL1A

MOBKL1A; MOB1, Mps One Binder kinase activator-like 1A (yeast)

299

3e-84

60% (50/82)

ACL00004551

unclassified

ACL00004552

SSU rRNA; A.castellanii mature small subunit rRNA gene, complete.

229

1e-127

97% (243/250)

ACL00004553

Psmc4

26S protease regulatory subunit 6B related cluster

126

2e-06

36% (37/101)

Posttranslational modification, protein turnover, chaperones

Proteasome

GO:0000166|nucleotide binding|IEA; GO:0000502|proteasome complex (sensu Eukaryota)|TAS; GO:0005524|ATP binding|IEA; GO:0005634|nucleus|IEA; GO:0005737|cytoplasm|IEA; GO:0005829|cytosol|IEA; GO:0006508|proteolysis and peptidolysis|TAS; GO:0016787|hydrolase activity|IEA; GO:0016887|ATPase activity|TAS; GO:0017111|nucleoside-triphosphatase activity|IEA; GO:0030163|protein catabolism|IEA

ACL00004554

unclassified

ACL00004557

F17A17.36; PHD finger protein-related

134

1e-07

30% (37/122)

ACL00004558

Rps15

Ribosomal protein S15 related cluster

302

3e-27

90% (54/60)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0015935|small ribosomal subunit|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00004559

Rplp1

60S acidic ribosomal protein P1 related cluster

138

4e-08

45% (26/57)

Translation, ribosomal structure and biogenesis

GO:0003723|RNA binding|TAS; GO:0003735|structural constituent of ribosome|IEA; GO:0003735|structural constituent of ribosome|TAS; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0005842|cytosolic large ribosomal subunit (sensu Eukaryota)|TAS; GO:0006412|protein biosynthesis|IEA; GO:0006412|protein biosynthesis|TAS; GO:0006414|translational elongation|IEA

ACL00004560

unclassified

ACL00004561

T8K14.13; LEM3 (ligand-effect modulator 3) family protein / CDC50 family protein

78

3e-22

62% (15/24)

ACL00004562

40S ribosomal protein S21 related cluster

199

2e-15

51% (41/79)

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0003735|structural constituent of ribosome|TAS; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0005843|cytosolic small ribosomal subunit (sensu Eukaryota)|TAS; GO:0006412|protein biosynthesis|IEA; GO:0006412|protein biosynthesis|TAS

ACL00004563

Profilin II related cluster

178

6e-13

97% (35/36)

GO:0003779|actin binding|IEA; GO:0005856|cytoskeleton|IEA; GO:0007010|cytoskeleton organization and biogenesis|IEA; GO:0015629|actin cytoskeleton|IEA; GO:0030036|actin cytoskeleton organization and biogenesis|IEA

ACL00004564

unclassified

ACL00004565

PSMD8

26S proteasome non-ATPase regulatory subunit 8 related cluster

126

1e-25

34% (29/85)

Proteasome

GO:0000074|regulation of cell cycle|NR; GO:0000502|proteasome complex (sensu Eukaryota)|TAS; GO:0005829|cytosol|IEA; GO:0005838|proteasome regulatory particle (sensu Eukaryota)|IEA; GO:0005838|proteasome regulatory particle (sensu Eukaryota)|TAS; GO:0006508|proteolysis and peptidolysis|IEA

ACL00004566

Histidyl-tRNA synthetase-like protein related cluster

442

3e-43

58% (79/134)

6.1.1.21

Translation, ribosomal structure and biogenesis

Aminoacyl-tRNA biosynthesis Histidine metabolism

GO:0004812|tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006418|tRNA aminoacylation for protein translation|IEA

ACL00004567

RAS-related protein racC related cluster

143

7e-09

65% (26/40)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00004568

unclassified

ACL00004570

ARD domain containing protein

330

2e-31

42% (55/129)

ACL00004571

prosaposin [Gallus gallus] gb|AAF05899.1| prosaposin [Gallus gallus]

138

1e-07

41% (28/67)

ACL00004572

Putative 40S ribosomal protein S24 related cluster

355

3e-33

73% (65/88)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00004573

unclassified

ACL00004574

multi-domain protein

111

6e-06

18% (39/210)

ACL00004576

ubiquitin domain containing protein

112

2e-06

27% (15/55)

ACL00004578

Myosin regulatory light chain related cluster

291

1e-25

42% (58/135)

GO:0005509|calcium ion binding|IEA; GO:0016459|myosin|IEA

ACL00004579

NDK

Nucleoside diphosphate kinase related cluster

48

7e-06

29% (12/41)

2.7.4.6

Nucleotide transport and metabolism

Purine metabolism Pyrimidine metabolism

GO:0000166|nucleotide binding|IEA; GO:0000287|magnesium ion binding|IEA; GO:0004550|nucleoside-diphosphate kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006183|GTP biosynthesis|IEA; GO:0006228|UTP biosynthesis|IEA; GO:0006241|CTP biosynthesis|IEA; GO:0009117|nucleotide metabolism|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00004581

UGP2

UDP-glucose pyrophosphorylase 2 related cluster

293

8e-26

46% (56/120)

2.7.7.9

Carbohydrate transport and metabolism

Galactose metabolism Nucleotide sugars metabolism Pentose and glucuronate interconversions Starch and sucrose metabolism

GO:0003983|UTP-glucose-1-phosphate uridylyltransferase activity|IEA; GO:0008152|metabolism|IEA; GO:0016740|transferase activity|IEA; GO:0016779|nucleotidyltransferase activity|IEA

ACL00004582

IGF2R

Mannose-6-phosphate/insulin-like growth factor II receptor related cluster

133

3e-07

28% (41/142)

GO:0004872|receptor activity|IEA; GO:0005215|transporter activity|IEA; GO:0005764|lysosome|IEA; GO:0006810|transport|IEA; GO:0016020|membrane|IEA

ACL00004583

MAP3K11

Putative serine/threonine-protein kinase ctr1 related cluster

191

6e-14

32% (47/145)

2.7.1.112

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0004713|protein-tyrosine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0008152|metabolism|IEA; GO:0016301|kinase activity|IEA; GO:0016597|amino acid binding|IEA; GO:0016740|transferase activity|IEA

ACL00004584

multi-domain protein

108

7e-06

30% (27/88)

ACL00004585

SLC30A5

Zinc transporter 5 related cluster

215

1e-16

40% (42/104)

GO:0006812|cation transport|IEA; GO:0008324|cation transporter activity|IEA; GO:0016020|membrane|IEA

ACL00004586

Dystrophin, isoforms A/C/DLP1/DLP3 related cluster

138

6e-08

41% (23/56)

GO:0003779|actin binding|IEA; GO:0003779|actin binding|ISS; GO:0005198|structural molecule activity|IEA; GO:0005200|structural constituent of cytoskeleton|ISS; GO:0005509|calcium ion binding|IEA; GO:0005856|cytoskeleton|IEA; GO:0005856|cytoskeleton|ISS; GO:0007517|muscle development|ISS; GO:0008270|zinc ion binding|IEA; GO:0008307|structural constituent of muscle|ISS

ACL00004587

unclassified

ACL00004588

multi-domain protein

232

7e-20

25% (89/345)

ACL00004589

unclassified

ACL00004590

ALG10

ALG10; asparagine-linked glycosylation 10 homolog (yeast, alpha-1,2-glucosyltransferase) [EC:2.4.1.-] [KO:K03850]

253

4e-21

32% (71/220)

2.4.1.-

N-Glycan biosynthesis

ACL00004591

Major facilitator family transporter related cluster

138

3e-08

40% (30/75)

GO:0005215|transporter activity|IEA; GO:0006810|transport|IEA; GO:0016021|integral to membrane|IEA

ACL00004592

possible zinc metallopeptidase

168

3e-11

24% (42/172)

ACL00004593

Similar to Xenopus laevis (African clawed frog). calcium/calmodulin-dependent protein kinase I alpha related cluster

92

2e-46

50% (18/36)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00004594

MDA7.19; transducin / WD-40 repeat protein family

762

4e-80

56% (141/249)

General function prediction only

ACL00004595

unclassified

ACL00004596

Putative serine/threonine-protein kinase ctr1 related cluster

222

3e-17

27% (66/242)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0004713|protein-tyrosine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0008152|metabolism|IEA; GO:0016301|kinase activity|IEA; GO:0016597|amino acid binding|IEA; GO:0016740|transferase activity|IEA

ACL00004597

UB2E3

Ubiquitin-conjugating enzyme E2 E3 related cluster

656

5e-68

74% (126/170)

6.3.2.19

Posttranslational modification, protein turnover, chaperones

GO:0004840|ubiquitin conjugating enzyme activity|IEA; GO:0004842|ubiquitin-protein ligase activity|IEA; GO:0006464|protein modification|IEA; GO:0006512|ubiquitin cycle|IEA; GO:0016874|ligase activity|IEA

ACL00004598

unclassified

ACL00004599

LYS1

Saccharopine dehydrogenase [NAD+, L-lysine forming] related cluster

405

7e-39

57% (84/147)

1.5.1.7

GO:0004754|saccharopine dehydrogenase (NAD+, L-lysine-forming) activity|IEA; GO:0006118|electron transport|IEA; GO:0009085|lysine biosynthesis|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00004601

CG3466

Cytochrome P450 4d2 related cluster

242

5e-20

37% (52/137)

1.14.-.-

Secondary metabolites biosynthesis, transport and catabolism

Ascorbate and aldarate metabolism Fluorene degradation Limonene and pinene degradation Stilbene, coumarine and lignin biosynthesis gamma-Hexachlorocyclohexane degradation

GO:0004497|monooxygenase activity|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0005792|microsome|IEA; GO:0006118|electron transport|IEA; GO:0016020|membrane|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00004602

CG3959

Similar to pelota homolog related cluster

943

1e-101

61% (173/283)

GO:0005634|nucleus|IEA; GO:0006412|protein biosynthesis|IEA

ACL00004603

multi-domain protein

110

7e-06

25% (41/160)

ACL00004604

Pgm2l1

Pgm2l1; phosphoglucomutase 2-like 1

629

1e-64

52% (127/243)

ACL00004605

Mandelate racemase /muconate lactonizing enzyme related protein related cluster

256

2e-21

36% (66/179)

GO:0003824|catalytic activity|IEA; GO:0008152|metabolism|IEA

ACL00004606

DUF298 domain containing protein

136

3e-09

46% (22/47)

ACL00004607

PH domain containing protein

128

5e-08

38% (26/67)

ACL00004608

Multifunctional cyclase-dehydratase-3-O-methyl transferase tcmN related cluster

282

4e-24

28% (90/316)

2.1.1.-

Aminophosphonate metabolism Androgen and estrogen metabolism Histidine metabolism Nitrobenzene degradation Selenoamino acid metabolism Tryptophan metabolism Tyrosine metabolism Ubiquinone biosynthesis

GO:0003824|catalytic activity|IEA; GO:0008168|methyltransferase activity|IEA; GO:0008171|O-methyltransferase activity|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA; GO:0016218|polyketide synthase activity|IEA; GO:0016740|transferase activity|IEA; GO:0017000|antibiotic biosynthesis|IEA

ACL00004609

unclassified

ACL00004610

unclassified

ACL00004611

Copper chaperone COX17-1 related cluster

42

2e-07

85% (6/7)

GO:0005507|copper ion binding|IEA; GO:0005758|mitochondrial intermembrane space|IEA; GO:0006825|copper ion transport|IEA; GO:0016531|copper chaperone activity|IEA

ACL00004612

putative homoisocitrate dehydrogenase

Putative homoisocitrate dehydrogenase, lysine biosynthesis related cluster

401

2e-38

48% (92/190)

GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00004613

Probable small nuclear ribonucleoprotein Sm D2 related cluster

400

1e-38

77% (77/99)

Transcription

GO:0000398|nuclear mRNA splicing, via spliceosome|IEA; GO:0000398|nuclear mRNA splicing, via spliceosome|ISS; GO:0005634|nucleus|IEA; GO:0005732|small nucleolar ribonucleoprotein complex|IEA; GO:0006397|mRNA processing|IEA; GO:0008248|pre-mRNA splicing factor activity|IEA; GO:0008248|pre-mRNA splicing factor activity|ISS; GO:0030529|ribonucleoprotein complex|IEA; GO:0030532|small nuclear ribonucleoprotein complex|ISS

ACL00004614

Unassigned protein

125

5e-06

37% (35/94)

ACL00004615

MDHC2

Malate dehydrogenase, cytoplasmic 2 related cluster

411

1e-39

53% (76/143)

1.1.1.37

Energy production and conversion

Carbon fixation Citrate cycle (TCA cycle) Glyoxylate and dicarboxylate metabolism Pyruvate metabolism Reductive carboxylate cycle (CO2 fixation)

GO:0006099|tricarboxylic acid cycle|IEA; GO:0006100|tricarboxylic acid cycle intermediate metabolism|IEA; GO:0006108|malate metabolism|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016615|malate dehydrogenase activity|IEA; GO:0030060|L-malate dehydrogenase activity|IEA

ACL00004616

GTP cyclohydrolase II related cluster

313

2e-28

42% (60/141)

3.5.4.25

Riboflavin metabolism

GO:0003935|GTP cyclohydrolase II activity|IEA; GO:0009231|riboflavin biosynthesis|IEA; GO:0016787|hydrolase activity|IEA

ACL00004617

STX8

Syntaxin 8 related cluster

169

9e-12

35% (47/131)

GO:0005783|endoplasmic reticulum|TAS; GO:0005887|integral to plasma membrane|TAS; GO:0006810|transport|IEA; GO:0006810|transport|TAS; GO:0016021|integral to membrane|IEA

ACL00004618

Putative dehydrogenase related cluster

274

3e-23

33% (74/219)

General function prediction only

GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00004619

CYP39A1

Cytochrome P450 39A1 related cluster

375

7e-35

32% (72/219)

1.14.13.-

Secondary metabolites biosynthesis, transport and catabolism

1,4-Dichlorobenzene degradation Androgen and estrogen metabolism Bile acid biosynthesis Biosynthesis of steroids Histidine metabolism Limonene and pinene degradation Methane metabolism Nitrobenzene degradation Phenylalanine metabolism Stilbene, coumarine and lignin biosynthesis Styrene degradation Tryptophan metabolism Tyrosine metabolism Ubiquinone biosynthesis gamma-Hexachlorocyclohexane degradation

GO:0004497|monooxygenase activity|IEA; GO:0005489|electron transporter activity|TAS; GO:0005783|endoplasmic reticulum|IEA; GO:0005792|microsome|IEA; GO:0005792|microsome|TAS; GO:0006118|electron transport|IEA; GO:0006699|bile acid biosynthesis|TAS; GO:0007586|digestion|TAS; GO:0008396|oxysterol 7-alpha-hydroxylase activity|TAS; GO:0016020|membrane|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0030573|bile acid catabolism|IEA

ACL00004620

SUCB

Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial precursor related cluster

772

3e-81

63% (152/241)

6.2.1.4

Energy production and conversion

GO:0003824|catalytic activity|IEA; GO:0004776|succinate-CoA ligase (GDP-forming) activity|IEA; GO:0005739|mitochondrion|IEA; GO:0006099|tricarboxylic acid cycle|IEA; GO:0008152|metabolism|IEA; GO:0016874|ligase activity|IEA

ACL00004621

O-methyltransferase related cluster

219

3e-17

53% (41/77)

2.1.1.-

General function prediction only

Aminophosphonate metabolism Androgen and estrogen metabolism Histidine metabolism Nitrobenzene degradation Selenoamino acid metabolism Tryptophan metabolism Tyrosine metabolism Ubiquinone biosynthesis

GO:0008168|methyltransferase activity|IEA; GO:0008171|O-methyltransferase activity|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00004622

LYPLA2

Related to lysophospholipase related cluster

78

1e-29

54% (12/22)

3.1.1.5

Phospholipid degradation

ACL00004623

Herpes_gp2 domain containing protein

110

6e-06

28% (34/121)

ACL00004624

GCN5L1

GCN5-like protein 1 related cluster

272

1e-23

48% (47/97)

GO:0000004|biological_process unknown|ND; GO:0005554|molecular_function unknown|ND; GO:0008372|cellular_component unknown|ND

ACL00004625

unclassified

ACL00004626

ldhA2

Lactate dehydrogenase and related dehydrogenases related cluster

529

4e-53

42% (105/247)

GO:0006564|L-serine biosynthesis|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016616|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|IEA

ACL00004627

unclassified

ACL00004628

PBXA homeodomain protein related cluster

359

3e-33

46% (64/139)

GO:0001764|neuronal migration|IDA; GO:0003677|DNA binding|IDA; GO:0003677|DNA binding|IEA; GO:0003700|transcription factor activity|IDA; GO:0003700|transcription factor activity|IEA; GO:0005634|nucleus|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0007411|axon guidance|IDA; GO:0030182|neuron cell differentiation|IMP; GO:0045449|regulation of transcription|IMP

ACL00004629

PPX2

Serine/threonine protein phosphatase PP-X isozyme 2 related cluster

327

1e-106

85% (60/70)

3.1.3.16

Signal transduction mechanisms

GO:0004721|phosphoprotein phosphatase activity|IEA; GO:0016787|hydrolase activity|IEA; GO:0030145|manganese ion binding|IEA

ACL00004630

Protein C20orf43 homolog related cluster

294

1e-25

35% (79/224)

ACL00004631

Polyketide cyclase related cluster

326

1e-29

36% (72/199)

ACL00004632

Mitochondrial 60S ribosomal protein L3 related cluster

177

2e-12

45% (36/79)

Translation, ribosomal structure and biogenesis

GO:0003723|RNA binding|TAS; GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005739|mitochondrion|IEA; GO:0005762|mitochondrial large ribosomal subunit|NR; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006412|protein biosynthesis|TAS

ACL00004633

UBC14

Ubiquitin-conjugating enzyme E2 14 related cluster

590

3e-60

70% (103/147)

6.3.2.19

Posttranslational modification, protein turnover, chaperones

GO:0004840|ubiquitin conjugating enzyme activity|IEA; GO:0004842|ubiquitin-protein ligase activity|IEA; GO:0006464|protein modification|IEA; GO:0006512|ubiquitin cycle|IEA; GO:0016874|ligase activity|IEA

ACL00004634

goa-1

Guanine nucleotide-binding protein G(o), alpha subunit related cluster

115

1e-37

80% (20/25)

GO:0004871|signal transducer activity|IEA; GO:0005525|GTP binding|IEA; GO:0007165|signal transduction|IEA; GO:0007186|G-protein coupled receptor protein signaling pathway|IEA

ACL00004635

unclassified

ACL00004637

FUMH

Fumarate hydratase, mitochondrial precursor related cluster

1130

1e-122

74% (218/294)

4.2.1.2

GO:0003824|catalytic activity|IEA; GO:0004333|fumarate hydratase activity|IEA; GO:0005739|mitochondrion|IEA; GO:0006099|tricarboxylic acid cycle|IEA; GO:0006106|fumarate metabolism|IEA; GO:0016829|lyase activity|IEA; GO:0045239|tricarboxylic acid cycle enzyme complex|IEA

ACL00004638

Rab4b

Ras-related protein Rab-4B related cluster

216

3e-74

66% (37/56)

GO:0003924|GTPase activity|NAS; GO:0005525|GTP binding|IEA; GO:0005622|intracellular|NAS; GO:0006886|intracellular protein transport|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA; GO:0016192|vesicle-mediated transport|NAS

ACL00004639

Oxidoreductase, Gfo/Idh/MocA family related cluster

379

1e-35

42% (82/195)

GO:0006118|electron transport|IEA; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00004640

srp1

Pre-mRNA splicing factor srp1 related cluster

156

1e-09

48% (35/72)

GO:0000398|nuclear mRNA splicing, via spliceosome|IEA; GO:0003723|RNA binding|IEA; GO:0005634|nucleus|IEA; GO:0006397|mRNA processing|IEA

ACL00004641

Putative nucleoside hydrolase protein related cluster

254

2e-21

34% (62/182)

3.2.2.-

Nucleotide transport and metabolism

GO:0005975|carbohydrate metabolism|IEA; GO:0016787|hydrolase activity|IEA; GO:0016798|hydrolase activity, acting on glycosyl bonds|IEA

ACL00004642

Putative transcription factor APFI related cluster

416

6e-40

44% (79/178)

ACL00004644

Talin homologue related cluster

207

1e-15

28% (52/182)

GO:0003779|actin binding|IEA; GO:0005856|cytoskeleton|IEA; GO:0007010|cytoskeleton organization and biogenesis|IEA

ACL00004645

MCB22.3; transducin family protein / WD-40 repeat family protein

146

5e-22

28% (49/172)

ACL00004646

CG5021

CG5021; CG5021 gene product from transcript CG5021-RA

156

1e-09

30% (33/109)

ACL00004647

ADL262Wp

Ras-like protein 1 related cluster

405

9e-39

53% (81/151)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00004648

Unassigned protein

ACL00004649

NUEM

NADH-ubiquinone oxidoreductase 39 kDa subunit, mitochondrial precursor related cluster

555

3e-56

50% (107/210)

1.6.5.3

Oxidative phosphorylation

GO:0003954|NADH dehydrogenase activity|IEA; GO:0003954|NADH dehydrogenase activity|NAS; GO:0005739|mitochondrion|IEA; GO:0005759|mitochondrial matrix|NAS; GO:0006814|sodium ion transport|NAS; GO:0008137|NADH dehydrogenase (ubiquinone) activity|NAS; GO:0016491|oxidoreductase activity|IEA

ACL00004650

Acetylornitine deacetylase related cluster

274

1e-23

41% (63/151)

Amino acid transport and metabolism

GO:0006508|proteolysis and peptidolysis|IEA; GO:0008237|metallopeptidase activity|IEA; GO:0009014|succinyl-diaminopimelate desuccinylase activity|IEA; GO:0009085|lysine biosynthesis|IEA; GO:0046872|metal ion binding|IEA

ACL00004651

Heat-shock protein related cluster

157

3e-10

41% (32/77)

GO:0005524|ATP binding|IEA

ACL00004652

multi-domain protein

156

3e-11

25% (30/116)

ACL00004653

SDCCAG3

Antigen NY-CO-3 homolog related cluster

146

6e-09

34% (41/118)

ACL00004654

unclassified

ACL00004655

PMM

Probable phosphomannomutase related cluster

704

2e-73

57% (126/220)

5.4.2.8

Fructose and mannose metabolism

GO:0003824|catalytic activity|IEA; GO:0004615|phosphomannomutase activity|IEA; GO:0005737|cytoplasm|IEA; GO:0008152|metabolism|IEA; GO:0016853|isomerase activity|IEA; GO:0019307|mannose biosynthesis|IEA

ACL00004656

unclassified

ACL00004657

unclassified

ACL00004658

Acetyl/propionyl CoA carboxylase, beta subunit related cluster

855

6e-91

71% (154/215)

6.4.1.3

Lipid transport and metabolism

Propanoate metabolism Valine, leucine and isoleucine degradation

GO:0004075|biotin carboxylase activity|IEA; GO:0009343|biotin carboxylase complex|IEA

ACL00004659

Similar to Dictyostelium discoideum (Slime mold). ankyrin repeat containing protein related cluster

154

5e-10

37% (33/89)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00004660

Herpes_gp2 domain containing protein

120

9e-07

19% (61/315)

ACL00004661

multi-domain protein

148

3e-10

29% (49/166)

ACL00004662

unclassified

ACL00004663

rplI

50S ribosomal protein L9 related cluster

197

7e-15

39% (55/141)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0019843|rRNA binding|IEA

ACL00004664

unclassified

ACL00004666

Glutathione S-transferase pi related cluster

206

6e-16

38% (57/149)

GO:0004364|glutathione transferase activity|IEA; GO:0008152|metabolism|IEA; GO:0016740|transferase activity|IEA

ACL00004668

unclassified

ACL00004669

Actin-binding protein fragmin P related cluster

350

4e-32

39% (85/217)

GO:0003779|actin binding|IEA

ACL00004670

DUT

Deoxyuridine 5'-triphosphate nucleotidohydrolase related cluster

463

1e-45

65% (90/137)

3.6.1.23

Pyrimidine metabolism

GO:0004170|dUTP diphosphatase activity|IEA; GO:0009117|nucleotide metabolism|IEA; GO:0016787|hydrolase activity|IEA; GO:0046080|dUTP metabolism|IEA

ACL00004671

Zinc transporter zupT related cluster

390

4e-37

50% (75/148)

Inorganic ion transport and metabolism

GO:0006810|transport|IEA; GO:0006829|zinc ion transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0030001|metal ion transport|IEA; GO:0046873|metal ion transporter activity|IEA

ACL00004672

unclassified

ACL00004673

Unassigned protein

129

8e-07

32% (38/118)

ACL00004674

MAPEG membrane-associated proteins in eicosanoid and glutath... precursor related cluster

215

5e-17

40% (48/119)

2.5.1.18

Glutathione metabolism

ACL00004675

Putative acyltransferase related cluster

380

2e-36

66% (68/103)

GO:0008080|N-acetyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00004676

PP2Cc domain containing protein

106

5e-07

26% (31/118)

ACL00004677

unclassified

ACL00004678

GCS1

Probable mannosyl-oligosaccharide glucosidase related cluster

125

3e-06

26% (34/130)

3.2.1.106

N-Glycan biosynthesis

GO:0004573|mannosyl-oligosaccharide glucosidase activity|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0009311|oligosaccharide metabolism|IEA; GO:0016021|integral to membrane|IEA; GO:0016787|hydrolase activity|IEA; GO:0016798|hydrolase activity, acting on glycosyl bonds|IEA

ACL00004679

isp6

Subtilisin-like serine proteinase related cluster

155

1e-44

80% (29/36)

3.4.21.-

Posttranslational modification, protein turnover, chaperones

GO:0004252|serine-type endopeptidase activity|IEA; GO:0004289|subtilase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA; GO:0042802|protein self binding|IEA; GO:0043086|negative regulation of enzyme activity|IEA

ACL00004680

unclassified

ACL00004681

lepA

GTP-binding protein lepA related cluster

520

3e-52

54% (92/168)

Cell wall/membrane/envelope biogenesis

GO:0003746|translation elongation factor activity|IEA; GO:0005525|GTP binding|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006414|translational elongation|IEA

ACL00004682

F6F3.4; ORMDL family protein

311

7e-28

41% (59/141)

ACL00004683

CPXB

Bifunctional P-450:NADPH-P450 reductase related cluster

302

8e-27

38% (76/200)

1.14.14.1

GO:0003824|catalytic activity|IEA; GO:0003958|NADPH-hemoprotein reductase activity|IEA; GO:0004497|monooxygenase activity|IEA; GO:0005489|electron transporter activity|IEA; GO:0006118|electron transport|IEA; GO:0010181|FMN binding|IEA; GO:0016020|membrane|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0050381|unspecific monooxygenase activity|IEA

ACL00004684

Unknown EST

128

8e-08

55% (26/47)

ACL00004685

IDHP

Isocitrate dehydrogenase [NADP], mitochondrial precursor related cluster

137

2e-07

36% (30/82)

1.1.1.42

Energy production and conversion

Citrate cycle (TCA cycle) Glutathione metabolism Reductive carboxylate cycle (CO2 fixation)

GO:0004450|isocitrate dehydrogenase (NADP+) activity|IEA; GO:0005739|mitochondrion|IEA; GO:0005739|mitochondrion|NR; GO:0005975|carbohydrate metabolism|NAS; GO:0006092|main pathways of carbohydrate metabolism|IEA; GO:0006097|glyoxylate cycle|IEA; GO:0006099|tricarboxylic acid cycle|IEA; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00004686

act-2

Actin, cytoplasmic 2 related cluster

267

1e-155

98% (50/51)

Cytoskeleton

GO:0005200|structural constituent of cytoskeleton|NR

ACL00004687

unclassified

ACL00004689

[LKJ] COG0513 Superfamily II DNA and RNA helicases

1520

1e-168

73% (286/391)

ACL00004690

Rps15a

40S ribosomal protein S15a related cluster

423

3e-41

78% (76/97)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003723|RNA binding|TAS; GO:0003735|structural constituent of ribosome|TAS; GO:0005843|cytosolic small ribosomal subunit (sensu Eukaryota)|TAS; GO:0006412|protein biosynthesis|TAS

ACL00004691

unclassified

ACL00004692

Actin, cytoplasmic 2 related cluster

653

2e-67

92% (124/134)

Cytoskeleton

GO:0005200|structural constituent of cytoskeleton|NR

ACL00004693

CG9075

Eukaryotic initiation factor 4A related cluster

151

2e-39

69% (29/42)

GO:0002168|larval development (sensu Insecta)|TAS; GO:0003676|nucleic acid binding|IEA; GO:0003677|DNA binding|IEA; GO:0003723|RNA binding|IEA; GO:0003743|translation initiation factor activity|IEA; GO:0004386|helicase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006412|protein biosynthesis|IEA; GO:0007446|imaginal disc growth|TAS; GO:0008026|ATP-dependent helicase activity|IEA

ACL00004694

ATPB

ATP synthase beta chain, mitochondrial precursor related cluster

419

3e-40

80% (84/104)

3.6.3.14

Energy production and conversion

ATP synthesis Oxidative phosphorylation

GO:0000166|nucleotide binding|IEA; GO:0005215|transporter activity|NAS; GO:0005524|ATP binding|IEA; GO:0005739|mitochondrion|IEA; GO:0005753|proton-transporting ATP synthase complex (sensu Eukaryota)|TAS; GO:0005754|proton-transporting ATP synthase, catalytic core (sensu Eukaryota)|TAS; GO:0006091|generation of precursor metabolites and energy|NR; GO:0006754|ATP biosynthesis|IEA; GO:0008553|hydrogen-exporting ATPase activity, phosphorylative mechanism|IEA; GO:0015078|hydrogen ion transporter activity|IEA; GO:0015986|ATP synthesis coupled proton transport|IEA; GO:0015992|proton transport|IEA; GO:0016021|integral to membrane|IEA; GO:0016469|proton-transporting two-sector ATPase complex|IEA; GO:0016787|hydrolase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA; GO:0045255|hydrogen-translocating F-type ATPase complex|IEA; GO:0046933|hydrogen-transporting ATP synthase activity, rotational mechanism|IEA; GO:0046961|hydrogen-transporting ATPase activity, rotational mechanism|IEA

ACL00004695

unclassified

ACL00004696

Unassigned protein

ACL00004697

unclassified

ACL00004698

ERG2

C-8 sterol isomerase related cluster

533

8e-54

57% (104/181)

GO:0000247|C-8 sterol isomerase activity|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0006696|ergosterol biosynthesis|IEA; GO:0016126|sterol biosynthesis|IEA; GO:0016853|isomerase activity|IEA

ACL00004699

2-enoyl thioester reductase related cluster

817

3e-86

50% (162/323)

GO:0004024|alcohol dehydrogenase activity, zinc-dependent|IEA; GO:0008270|zinc ion binding|IEA

ACL00004700

Glyceraldehyde-3-phosphate dehydrogenase related cluster

234

1e-102

54% (46/85)

1.2.1.12

Carbohydrate transport and metabolism

Glycolysis / Gluconeogenesis

GO:0004365|glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity|IEA; GO:0006006|glucose metabolism|IEA; GO:0006096|glycolysis|IEA; GO:0008943|glyceraldehyde-3-phosphate dehydrogenase activity|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00004701

Sec61g

Protein transport protein SEC61 gamma subunit related cluster

120

3e-06

58% (24/41)

GO:0005783|endoplasmic reticulum|IEA; GO:0005789|endoplasmic reticulum membrane|ISS; GO:0006605|protein targeting|IEA; GO:0006886|intracellular protein transport|IEA; GO:0006886|intracellular protein transport|ISS; GO:0008565|protein transporter activity|ISS; GO:0015031|protein transport|IEA; GO:0015031|protein transport|ISS; GO:0015450|protein translocase activity|IEA; GO:0015450|protein translocase activity|ISS; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0030176|integral to endoplasmic reticulum membrane|ISS

ACL00004702

unclassified

ACL00004703

DUF75 domain containing protein

163

4e-12

23% (23/99)

ACL00004704

Atrophin-1 domain containing protein

112

5e-06

21% (30/137)

ACL00004705

unclassified

ACL00004706

Polyubiquitin related cluster

1110

1e-120

97% (222/228)

ACL00004707

unclassified

ACL00004708

Similar to glutamate oxaloacetate transaminase 2 related cluster

131

7e-76

28% (44/156)

GO:0003824|catalytic activity|IEA; GO:0006520|amino acid metabolism|IEA; GO:0008483|transaminase activity|IEA; GO:0009058|biosynthesis|IEA; GO:0016740|transferase activity|IEA

ACL00004709

CulA related cluster

403

2e-38

51% (86/166)

GO:0007049|cell cycle|IEA

ACL00004710

Sorting nexin 3 related cluster

200

6e-15

39% (51/130)

GO:0006810|transport|IEA; GO:0006897|endocytosis|TAS; GO:0007242|intracellular signaling cascade|IEA; GO:0015031|protein transport|IEA

ACL00004711

METK

S-adenosylmethionine synthetase related cluster

220

2e-17

95% (40/42)

2.5.1.6

Coenzyme transport and metabolism

Methionine metabolism Selenoamino acid metabolism

GO:0000287|magnesium ion binding|IEA; GO:0004478|methionine adenosyltransferase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006730|one-carbon compound metabolism|IEA; GO:0016740|transferase activity|IEA

ACL00004712

unclassified

ACL00004713

Probable pyridoxin biosynthesis PDX1-like protein related cluster

50

9e-90

90% (10/11)

Coenzyme transport and metabolism

GO:0005554|molecular_function unknown|IEA; GO:0008615|pyridoxine biosynthesis|IEA

ACL00004714

Ribosomal protein L30 related cluster

421

4e-41

84% (79/93)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00004715

elovl6l

Similar to fatty acid elongase 2 related cluster

373

4e-35

41% (73/174)

GO:0016021|integral to membrane|IEA

ACL00004716

RIOK1

RIO kinase 1, isoform 1 related cluster

583

3e-59

43% (117/267)

2.7.1.37

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0005554|molecular_function unknown|IEA; GO:0016740|transferase activity|IEA

ACL00004717

30S ribosomal protein S15 related cluster

190

2e-13

45% (37/82)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0019843|rRNA binding|IEA

ACL00004718

Methyltransferase related cluster

67

5e-24

44% (13/29)

GO:0008168|methyltransferase activity|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00004719

2-hydroxychromene-2-carboxylate isomerase family protein related cluster

274

1e-23

34% (62/179)

Secondary metabolites biosynthesis, transport and catabolism

GO:0015035|protein disulfide oxidoreductase activity|IEA; GO:0016853|isomerase activity|IEA; GO:0030288|periplasmic space (sensu Gram-negative Bacteria)|IEA

ACL00004720

unclassified

ACL00004721

unclassified

ACL00004722

Probable amino acid decarboxylase related cluster

445

2e-43

48% (97/198)

4.1.1.19

Amino acid transport and metabolism

Arginine and proline metabolism Glutamate metabolism

GO:0003824|catalytic activity|IEA

ACL00004723

Hspa4

Heat-shock protein related cluster

891

9e-95

48% (179/367)

GO:0005524|ATP binding|IEA

ACL00004724

AATC

Aspartate aminotransferase, cytoplasmic related cluster

694

3e-72

63% (139/219)

2.6.1.1

Amino acid transport and metabolism

Alanine and aspartate metabolism Alkaloid biosynthesis I Arginine and proline metabolism Carbon fixation Cysteine metabolism Glutamate metabolism Novobiocin biosynthesis Phenylalanine metabolism Phenylalanine, tyrosine and tryptophan biosynthesis Tyrosine metabolism

GO:0003824|catalytic activity|IEA; GO:0004069|aspartate transaminase activity|IEA; GO:0006520|amino acid metabolism|IEA; GO:0008483|transaminase activity|IEA; GO:0009058|biosynthesis|IEA; GO:0016740|transferase activity|IEA

ACL00004725

Cytosol aminopeptidase, putative related cluster

343

1e-31

49% (72/145)

3.4.11.1

GO:0004177|aminopeptidase activity|IEA; GO:0004178|leucyl aminopeptidase activity|IEA; GO:0005622|intracellular|IEA; GO:0005737|cytoplasm|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0019538|protein metabolism|IEA; GO:0030145|manganese ion binding|IEA

ACL00004726

Unassigned protein

ACL00004727

multi-domain protein

116

2e-06

19% (68/357)

ACL00004728

unclassified

ACL00004729

ATPG

ATP synthase gamma chain related cluster

246

2e-20

48% (54/112)

3.6.3.14

Energy production and conversion

ATP synthesis Oxidative phosphorylation

GO:0006754|ATP biosynthesis|IEA; GO:0015078|hydrogen ion transporter activity|IEA; GO:0015986|ATP synthesis coupled proton transport|IEA; GO:0015992|proton transport|IEA; GO:0016020|membrane|IEA; GO:0016469|proton-transporting two-sector ATPase complex|IEA; GO:0016787|hydrolase activity|IEA; GO:0046933|hydrogen-transporting ATP synthase activity, rotational mechanism|IEA; GO:0046961|hydrogen-transporting ATPase activity, rotational mechanism|IEA

ACL00004730

Polyubiquitin related cluster

1110

1e-120

97% (222/228)

ACL00004731

40S ribosomal protein S19 related cluster

273

6e-24

61% (47/76)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00004732

GTP-binding protein Rac1p related cluster

795

6e-84

78% (146/187)

General function prediction only

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00004733

multi-domain protein

131

3e-08

25% (52/206)

ACL00004734

pdc

Pyruvate decarboxylase related cluster

351

1e-32

41% (78/189)

4.1.1.1

Glycolysis / Gluconeogenesis

ACL00004735

Rab1

Ras-related protein Rab-1A related cluster

715

1e-74

68% (134/197)

GO:0005525|GTP binding|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0005794|Golgi apparatus|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00004736

Tyrosine transporter hoepel2 related cluster

239

4e-19

59% (45/76)

GO:0015137|citrate transporter activity|IEA; GO:0015746|citrate transport|IEA; GO:0016021|integral to membrane|IEA

ACL00004737

Histone H3 related cluster

408

3e-39

82% (81/98)

Chromatin structure and dynamics

GO:0000786|nucleosome|IEA; GO:0003677|DNA binding|IEA; GO:0005634|nucleus|IEA; GO:0005694|chromosome|IEA; GO:0006334|nucleosome assembly|IEA; GO:0007001|chromosome organization and biogenesis (sensu Eukaryota)|IEA

ACL00004738

Casein kinase II beta chain related cluster

702

7e-73

57% (132/230)

Circadian rhythm

GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005956|protein kinase CK2 complex|IEA; GO:0008605|protein kinase CK2 regulator activity|IEA; GO:0016740|transferase activity|IEA

ACL00004739

Universal stress protein UspA and related nucleotide-binding proteins related cluster

157

4e-10

28% (41/143)

Signal transduction mechanisms

GO:0006950|response to stress|IEA

ACL00004741

multi-domain protein

125

2e-07

21% (44/204)

ACL00004742

RPL7

60S ribosomal protein L7 related cluster

406

2e-39

72% (71/98)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00004743

unclassified

ACL00004745

unclassified

ACL00004747

30 kDa heat shock protein related cluster

179

2e-12

30% (42/139)

Posttranslational modification, protein turnover, chaperones

GO:0006457|protein folding|IEA; GO:0006986|response to unfolded protein|IEA

ACL00004748

Similar to Mus musculus (Mouse). similar to 60S ribosomal protein L30 isolog related cluster

504

3e-50

60% (90/149)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005634|nucleus|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0007046|ribosome biogenesis|IEA

ACL00004749

F5K20.290; universal stress protein (USP) family protein

167

2e-11

28% (46/159)

Signal transduction mechanisms

ACL00004750

TT_ORF1 domain containing protein

116

2e-06

34% (32/94)

ACL00004751

unclassified

ACL00004753

unclassified

ACL00004754

RNA polymerase B transcription factor 3 related cluster

286

2e-25

48% (62/129)

ACL00004755

act-4

Actin, cytoplasmic 2 related cluster

1884

0.0

95% (359/375)

Cytoskeleton

GO:0005200|structural constituent of cytoskeleton|NR

ACL00004756

DNA-binding protein GBP16 related cluster

484

8e-48

56% (94/167)

GO:0003677|DNA binding|IEA; GO:0004239|methionyl aminopeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008235|metalloexopeptidase activity|IEA

ACL00004759

Putative disulfide-isomerase related cluster

305

1e-26

57% (55/95)

ACL00004760

Coactosin related cluster

233

1e-18

51% (43/84)

GO:0003779|actin binding|IEA; GO:0005622|intracellular|IEA; GO:0005856|cytoskeleton|IEA

ACL00004762

Putative peroxiredoxin, mitochondrial precursor related cluster

380

8e-36

53% (72/135)

Posttranslational modification, protein turnover, chaperones

GO:0005739|mitochondrion|IEA

ACL00004763

Unassigned protein

ACL00004765

T12C14.250; universal stress protein (USP) family protein

151

3e-09

30% (47/152)

Signal transduction mechanisms

ACL00004766

RAS-related protein racC related cluster

758

2e-79

73% (136/186)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00004767

Herpes_gp2 domain containing protein

118

1e-06

22% (53/233)

ACL00004768

Unassigned protein

ACL00004770

Profilins IA/IB related cluster

607

1e-62

95% (119/125)

ACL00004772

Rpl31

60S ribosomal protein L31 related cluster

422

6e-41

68% (80/117)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00004775

Rplp2

Acidic ribosomal protein related cluster

168

1e-11

62% (31/50)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006414|translational elongation|IEA

ACL00004776

Polyubiquitin related cluster

1111

1e-120

96% (222/229)

ACL00004777

Putative ribosomal protein L26 related cluster

393

1e-37

70% (71/101)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0015934|large ribosomal subunit|IEA

ACL00004778

act-2

Actin, cytoplasmic 2 related cluster

354

0.0

97% (67/69)

Cytoskeleton

GO:0005200|structural constituent of cytoskeleton|NR

ACL00004779

Unassigned protein

165

8e-11

32% (60/184)

ACL00004781

LIM domain protein related cluster

95

3e-10

51% (15/29)

GO:0008270|zinc ion binding|IEA

ACL00004782

act-4

Actin, cytoplasmic 2 related cluster

1796

0.0

91% (343/373)

Cytoskeleton

GO:0005200|structural constituent of cytoskeleton|NR

ACL00004786

cdc3

Profilin II related cluster

627

1e-64

100% (124/124)

GO:0003779|actin binding|IEA; GO:0005856|cytoskeleton|IEA; GO:0007010|cytoskeleton organization and biogenesis|IEA; GO:0015629|actin cytoskeleton|IEA; GO:0030036|actin cytoskeleton organization and biogenesis|IEA

ACL00004787

multi-domain protein

117

2e-06

24% (40/163)

ACL00004788

60S ribosomal protein L4A related cluster

975

1e-104

54% (200/369)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00004790

Vacuolar type H+-ATPase proteolipid subunit related cluster

452

4e-44

67% (90/134)

3.6.3.14

Energy production and conversion

ATP synthesis Oxidative phosphorylation Photosynthesis

GO:0006754|ATP biosynthesis|IEA; GO:0006810|transport|IEA; GO:0006811|ion transport|IEA; GO:0015078|hydrogen ion transporter activity|IEA; GO:0015986|ATP synthesis coupled proton transport|IEA; GO:0015992|proton transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016469|proton-transporting two-sector ATPase complex|IEA; GO:0016787|hydrolase activity|IEA; GO:0046933|hydrogen-transporting ATP synthase activity, rotational mechanism|IEA; GO:0046961|hydrogen-transporting ATPase activity, rotational mechanism|IEA

ACL00004791

PPCK

Phosphoenolpyruvate carboxykinase related cluster

853

0.0

60% (162/270)

4.1.1.49

Energy production and conversion

GO:0004611|phosphoenolpyruvate carboxykinase activity|IEA; GO:0004612|phosphoenolpyruvate carboxykinase (ATP) activity|IEA; GO:0005524|ATP binding|IEA; GO:0005525|GTP binding|IEA; GO:0006094|gluconeogenesis|IEA; GO:0016829|lyase activity|IEA; GO:0016831|carboxy-lyase activity|IEA

ACL00004793

Rpl36a

60S ribosomal protein L36a related cluster

250

1e-20

80% (44/55)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0000004|biological_process unknown|ND; GO:0003735|structural constituent of ribosome|IEA; GO:0005554|molecular_function unknown|ND; GO:0005622|intracellular|IEA; GO:0005737|cytoplasm|NAS; GO:0005840|ribosome|IEA; GO:0005840|ribosome|NAS; GO:0006412|protein biosynthesis|IEA

ACL00004794

YWHAE

14-3-3 protein epsilon related cluster

983

1e-105

82% (193/234)

GO:0005515|protein binding|TAS; GO:0007165|signal transduction|TAS; GO:0007242|intracellular signaling cascade|TAS; GO:0008426|protein kinase C inhibitor activity|TAS; GO:0019899|enzyme binding|IPI

ACL00004795

Rps20

40S ribosomal protein S20 related cluster

463

1e-45

81% (91/112)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0015935|small ribosomal subunit|IEA

ACL00004797

multi-domain protein

114

3e-06

28% (46/161)

ACL00004798

EEF1G

Eukaryotic translation elongation factor 1 gamma related cluster

341

1e-30

44% (66/147)

GO:0003746|translation elongation factor activity|IEA; GO:0005853|eukaryotic translation elongation factor 1 complex|IEA; GO:0006414|translational elongation|IEA

ACL00004800

40S ribosomal protein S3a related cluster

804

7e-85

66% (153/230)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00004802

Eef1a1

Elongation factor 1-alpha related cluster

942

1e-101

83% (176/210)

3.6.5.3

Translation, ribosomal structure and biogenesis

GO:0003746|translation elongation factor activity|IEA; GO:0005525|GTP binding|IEA; GO:0005737|cytoplasm|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006414|translational elongation|IEA

ACL00005990

unclassified

ACL00005991

unclassified

ACL00005993

unclassified

ACL00008269

unclassified

ACL00008270

unclassified

ACL00008271

unclassified

ACL00008272

unclassified

ACL00008273

unclassified

ACL00008274

unclassified

ACL00008275

unclassified

ACL00008276

unclassified

ACL00008277

unclassified

ACL00008279

unclassified

ACL00008280

unclassified

ACL00008281

unclassified

ACL00008282

unclassified

ACL00008283

unclassified

ACL00008284

RPB11

DNA-directed RNA polymerase II 13.3 kDa polypeptide related cluster

299

6e-27

57% (56/97)

2.7.7.6

Transcription

Purine metabolism Pyrimidine metabolism RNA polymerase

GO:0003677|DNA binding|IEA; GO:0003899|DNA-directed RNA polymerase activity|IEA; GO:0003899|DNA-directed RNA polymerase activity|TAS; GO:0005634|nucleus|IEA; GO:0005665|DNA-directed RNA polymerase II, core complex|TAS; GO:0006350|transcription|IEA; GO:0006366|transcription from Pol II promoter|TAS; GO:0016740|transferase activity|IEA; GO:0046983|protein dimerization activity|IEA

ACL00008286

unclassified

ACL00008287

APC_basic domain containing protein

117

9e-07

23% (41/176)

ACL00008288

unclassified

ACL00008289

Unassigned protein

ACL00008290

SnoK-like protein related cluster

152

7e-10

35% (32/91)

ACL00008291

unclassified

ACL00008292

multi-domain protein

137

4e-09

21% (28/129)

ACL00008293

[Z] COG5199 Calponin

151

5e-10

31% (32/101)

Cytoskeleton

ACL00008294

unclassified

ACL00008295

DENR

Density-regulated protein homolog related cluster

196

5e-15

33% (47/140)

GO:0003743|translation initiation factor activity|IEA; GO:0006413|translational initiation|IEA; GO:0008151||IEA

ACL00008296

PTEN

PTEN related cluster

392

2e-37

59% (74/124)

3.1.3.67

Inositol phosphate metabolism Phosphatidylinositol signaling system

GO:0004721|phosphoprotein phosphatase activity|IEA; GO:0006470|protein amino acid dephosphorylation|IEA; GO:0016787|hydrolase activity|IEA

ACL00008297

Aldehyde dehydrogenase ALDH1 related cluster

113

1e-17

61% (19/31)

Energy production and conversion

GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00008298

CG3985

Synapsin IIa related cluster

197

7e-15

38% (47/121)

GO:0007269|neurotransmitter secretion|IEA; GO:0008021|synaptic vesicle|IEA

ACL00008299

Unassigned protein

80

2e-06

29% (28/95)

ACL00008300

KH domain containing protein

103

7e-07

36% (16/44)

ACL00008301

unclassified

ACL00008302

CTP synthetase isoform related cluster

291

8e-26

62% (54/86)

Nucleotide transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0003883|CTP synthase activity|IEA; GO:0003883|CTP synthase activity|TAS; GO:0006220|pyrimidine nucleotide metabolism|TAS; GO:0006221|pyrimidine nucleotide biosynthesis|IEA; GO:0016874|ligase activity|IEA

ACL00008303

unclassified

ACL00008304

multi-domain protein

115

6e-07

39% (27/68)

ACL00008305

RhoGEF domain containing protein

119

2e-08

31% (19/60)

ACL00008306

unclassified

ACL00008307

GCP

Probable O-sialoglycoprotein endopeptidase related cluster

998

1e-107

74% (188/252)

3.4.24.57

GO:0006508|proteolysis and peptidolysis|IEA; GO:0008237|metallopeptidase activity|IEA; GO:0008270|zinc ion binding|IEA; GO:0008450|O-sialoglycoprotein endopeptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00008308

[R] COG4341 Predicted HD phosphohydrolase

70

3e-10

51% (15/29)

General function prediction only

ACL00008309

unclassified

ACL00008310

unclassified

ACL00008311

Ncdn

Ncdn; neurochondrin

192

5e-14

31% (69/217)

ACL00008312

Exportin T related cluster

400

3e-38

37% (82/221)

GO:0000049|tRNA binding|IEA; GO:0000049|tRNA binding|TAS; GO:0005488|binding|IEA; GO:0005634|nucleus|IEA; GO:0006810|transport|IEA

ACL00008313

Gart

Gart; phosphoribosylglycinamide formyltransferase [EC:6.3.4.13 6.3.3.1 2.1.2.2] [KO:K00601 K01933 K01945]

601

1e-61

59% (118/200)

6.3.4.13 6.3.3.1 2.1.2.2

One carbon pool by folate Purine metabolism

ACL00008314

multi-domain protein

118

1e-06

19% (52/264)

ACL00008315

unclassified

ACL00008316

PSMD3

26S proteasome non-ATPase regulatory subunit 3 related cluster

537

2e-54

62% (103/165)

Proteasome

GO:0000502|proteasome complex (sensu Eukaryota)|TAS; GO:0005488|binding|IEA; GO:0005829|cytosol|IEA

ACL00008317

unclassified

ACL00008318

multi-domain protein

140

2e-09

22% (38/166)

ACL00008319

unclassified

ACL00008320

unclassified

ACL00008321

Type I phosphodiesterase/nucleotide pyrophosphatase family protein related cluster

341

1e-31

45% (66/144)

GO:0009117|nucleotide metabolism|IEA; GO:0016787|hydrolase activity|IEA

ACL00008322

unclassified

ACL00008323

yfmJ

YFMJ protein related cluster

437

2e-42

44% (98/222)

GO:0004024|alcohol dehydrogenase activity, zinc-dependent|IEA; GO:0008270|zinc ion binding|IEA

ACL00008324

Unassigned protein

149

1e-09

52% (31/59)

ACL00008325

Putative serine palmitoyltransferase related cluster

178

3e-56

78% (33/42)

GO:0003824|catalytic activity|IEA; GO:0009058|biosynthesis|IEA; GO:0016740|transferase activity|IEA

ACL00008326

Keratin_B2 domain containing protein

109

8e-06

27% (35/126)

ACL00008327

unclassified

ACL00008328

RAD21

Double-strand-break repair protein rad21 homolog related cluster

350

2e-32

47% (72/152)

GO:0000228|nuclear chromosome|IEA; GO:0005634|nucleus|IEA; GO:0006281|DNA repair|IEA; GO:0006915|apoptosis|IEA; GO:0007001|chromosome organization and biogenesis (sensu Eukaryota)|IEA; GO:0007049|cell cycle|IEA; GO:0007059|chromosome segregation|IEA; GO:0007067|mitosis|IEA

ACL00008329

XYNB

Beta-xylosidase related cluster

486

4e-48

41% (103/248)

3.2.1.37

Carbohydrate transport and metabolism

GO:0004553|hydrolase activity, hydrolyzing O-glycosyl compounds|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0009044|xylan 1,4-beta-xylosidase activity|IEA; GO:0016787|hydrolase activity|IEA; GO:0016798|hydrolase activity, acting on glycosyl bonds|IEA

ACL00008330

[S] COG5202 Predicted membrane protein

238

5e-20

32% (58/179)

Function unknown

ACL00008331

UMP synthase related cluster

534

1e-53

46% (108/232)

GO:0004588|orotate phosphoribosyltransferase activity|IEA; GO:0004590|orotidine-5'-phosphate decarboxylase activity|IEA; GO:0006207|'de novo' pyrimidine base biosynthesis|IEA; GO:0006221|pyrimidine nucleotide biosynthesis|IEA; GO:0009116|nucleoside metabolism|IEA; GO:0016740|transferase activity|IEA; GO:0016757|transferase activity, transferring glycosyl groups|IEA

ACL00008332

unclassified

ACL00008333

unclassified

ACL00008334

tRNA_m1G_MT_9 domain containing protein

119

7e-07

29% (20/68)

ACL00008335

Nvp3

Similar to Mus musculus (Mouse), and Rattus norvegicus (Rat). neuron specific calcium-binding protein hippocalcin related cluster

173

4e-12

31% (45/145)

GO:0005509|calcium ion binding|IEA

ACL00008336

Sensor protein fixL related cluster

143

7e-09

50% (29/58)

GO:0000155|two-component sensor molecule activity|IEA; GO:0000160|two-component signal transduction system (phosphorelay)|IEA; GO:0004871|signal transducer activity|IEA; GO:0005524|ATP binding|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0007165|signal transduction|IEA; GO:0007600|sensory perception|IEA; GO:0016020|membrane|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00008337

multi-domain protein

144

8e-10

24% (55/227)

ACL00008338

P2CB

Protein phosphatase 2C beta isoform related cluster

216

7e-17

38% (53/139)

3.1.3.16

Signal transduction mechanisms

MAPK signaling pathway

GO:0000287|magnesium ion binding|IEA; GO:0003824|catalytic activity|IEA; GO:0004721|phosphoprotein phosphatase activity|IEA; GO:0004722|protein serine/threonine phosphatase activity|IEA; GO:0006470|protein amino acid dephosphorylation|IEA; GO:0006470|protein amino acid dephosphorylation|TAS; GO:0008287|protein serine/threonine phosphatase complex|IEA; GO:0015071|protein phosphatase type 2C activity|TAS; GO:0016787|hydrolase activity|IEA; GO:0030145|manganese ion binding|IEA

ACL00008339

unclassified

ACL00008340

unclassified

ACL00008341

unclassified

ACL00008342

F13M14.8; glycosyl transferase family 1 protein

264

2e-22

41% (65/158)

Cell wall/membrane/envelope biogenesis

ACL00008343

Herpes_BLLF1 domain containing protein

109

9e-06

24% (52/215)

ACL00008344

CG8887

CG8887; absent, small, or homeotic discs 1

145

1e-08

30% (42/136)

ACL00008345

unclassified

ACL00008346

Putative RING zinc finger protein related cluster

167

1e-11

39% (27/69)

GO:0000151|ubiquitin ligase complex|IEA; GO:0004842|ubiquitin-protein ligase activity|IEA; GO:0008270|zinc ion binding|IEA; GO:0016567|protein ubiquitination|IEA

ACL00008347

FAS2

Fatty acid synthase subunit alpha related cluster

136

4e-43

58% (24/41)

1.1.1.100

GO:0000287|magnesium ion binding|IEA; GO:0003824|catalytic activity|IEA; GO:0004315|3-oxoacyl-[acyl-carrier protein] synthase activity|IEA; GO:0004316|3-oxoacyl-[acyl-carrier protein] reductase activity|IEA; GO:0004321|fatty-acyl-CoA synthase activity|IEA; GO:0006633|fatty acid biosynthesis|IEA; GO:0008897|phosphopantetheinyltransferase activity|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016740|transferase activity|IEA

ACL00008348

unclassified

ACL00008349

unclassified

ACL00008350

HIS8

Histidinol phosphate aminotransferase precursor related cluster

116

1e-20

45% (24/53)

2.6.1.9

Amino acid transport and metabolism

Histidine metabolism Novobiocin biosynthesis Phenylalanine metabolism Phenylalanine, tyrosine and tryptophan biosynthesis Tyrosine metabolism

GO:0000105|histidine biosynthesis|IEA; GO:0003824|catalytic activity|IEA; GO:0004400|histidinol-phosphate transaminase activity|IEA; GO:0008483|transaminase activity|IEA; GO:0009058|biosynthesis|IEA; GO:0009507|chloroplast|IEA; GO:0016740|transferase activity|IEA

ACL00008351

putative cullin 3B [Oryza sativa (japonica cultivar-group)] dbj|BAD05712.1| putative cullin 3B [Oryza sativa (japonica cultivar-group)] dbj|BAD05794.1| putative cullin 3B [Oryza sativa (japonica cultivar-group)]

127

4e-06

40% (25/62)

ACL00008352

BAG domain containing protein

92

3e-05

30% (17/56)

ACL00008353

multi-domain protein

133

2e-08

23% (48/203)

ACL00008354

multi-domain protein

129

4e-08

26% (32/122)

ACL00008355

Mannose-P-dolichol utilization defect 1 protein homolog related cluster

171

4e-12

40% (31/77)

GO:0016021|integral to membrane|IEA

ACL00008356

Smarca3

Smarca3; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3

160

1e-10

36% (45/125)

ACL00008357

SYRC

Arginyl-tRNA synthetase, cytoplasmic related cluster

711

3e-74

56% (132/232)

6.1.1.19

Translation, ribosomal structure and biogenesis

GO:0004812|tRNA ligase activity|IEA; GO:0004814|arginine-tRNA ligase activity|IDA; GO:0004814|arginine-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0005737|cytoplasm|IC; GO:0005739|mitochondrion|IDA; GO:0006412|protein biosynthesis|IDA; GO:0006412|protein biosynthesis|IEA; GO:0006418|tRNA aminoacylation for protein translation|IEA; GO:0006420|arginyl-tRNA aminoacylation|IEA; GO:0016874|ligase activity|IEA

ACL00008358

unclassified

ACL00008359

Unassigned protein

ACL00008360

HCA66

Hepatocellular carcinoma-associated antigen 66 related cluster

323

3e-29

31% (63/199)

GO:0005488|binding|IEA; GO:0005622|intracellular|IEA; GO:0006396|RNA processing|IEA

ACL00008361

Putative ATP/GTP binding protein related cluster

314

3e-28

33% (69/205)

ACL00008362

unclassified

ACL00008363

Penta-EF-hand Ca2+-binding protein related cluster

167

2e-11

42% (32/75)

GO:0005509|calcium ion binding|IEA

ACL00008364

unclassified

ACL00008365

unclassified

ACL00008366

CG17556

Similar to KIAA0103 gene product related cluster

393

2e-37

42% (82/191)

GO:0005488|binding|IEA

ACL00008367

unclassified

ACL00008368

Unassigned protein

123

3e-06

26% (26/97)

ACL00008369

Polyferredoxin related cluster

201

4e-15

26% (59/225)

Energy production and conversion

GO:0005489|electron transporter activity|IEA; GO:0005506|iron ion binding|IEA; GO:0006118|electron transport|IEA

ACL00008370

unclassified

ACL00008371

Centromere/microtubule binding protein cbf5 related cluster

392

2e-37

56% (74/130)

GO:0000775|chromosome, pericentric region|IEA; GO:0003677|DNA binding|IEA; GO:0003723|RNA binding|IEA; GO:0004730|pseudouridylate synthase activity|IEA; GO:0005634|nucleus|IEA; GO:0006364|rRNA processing|IEA; GO:0006396|RNA processing|IEA; GO:0007046|ribosome biogenesis|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00008372

STATc protein related cluster

443

4e-43

40% (91/226)

GO:0007242|intracellular signaling cascade|IEA

ACL00008373

multi-domain protein

117

1e-06

24% (45/184)

ACL00008374

unclassified

ACL00008375

unclassified

ACL00008376

unclassified

ACL00008377

unclassified

ACL00008378

Putative serine/threonine-specific protein kinase related cluster

304

5e-27

41% (64/153)

GO:0004672|protein kinase activity|IEA; GO:0004713|protein-tyrosine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00008379

unclassified

ACL00008380

unclassified

ACL00008381

unclassified

ACL00008382

unclassified

ACL00008383

unclassified

ACL00008384

Protovillin related cluster

192

4e-14

32% (47/145)

GO:0003779|actin binding|IEA; GO:0005856|cytoskeleton|IEA; GO:0007010|cytoskeleton organization and biogenesis|IEA

ACL00008385

CBWD2

COBW domain-containing protein related cluster

115

2e-34

50% (21/42)

ACL00008386

Unknown EST

74

7e-09

33% (19/57)

ACL00008387

unclassified

ACL00008388

MAP kinase, putative related cluster

297

2e-26

39% (65/163)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0004713|protein-tyrosine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00008389

CAIB/BAIF family protein related cluster

546

1e-55

67% (97/144)

GO:0008152|metabolism|IEA

ACL00008390

multi-domain protein

130

3e-08

50% (25/50)

ACL00008391

Unassigned protein

ACL00008392

unclassified

ACL00008393

unclassified

ACL00008394

Protein phosphatase 2C-like protein related cluster

240

2e-19

39% (71/178)

Signal transduction mechanisms

GO:0000287|magnesium ion binding|IEA; GO:0003824|catalytic activity|IEA; GO:0004722|protein serine/threonine phosphatase activity|IEA; GO:0006470|protein amino acid dephosphorylation|IEA; GO:0008287|protein serine/threonine phosphatase complex|IEA; GO:0016787|hydrolase activity|IEA

ACL00008395

unclassified

ACL00008396

FCH domain containing protein

142

6e-10

25% (22/86)

ACL00008397

trxA

Thioredoxin related cluster

228

2e-18

35% (42/119)

Posttranslational modification, protein turnover, chaperones

GO:0005488|binding|IEA; GO:0005489|electron transporter activity|IEA; GO:0006011|UDP-glucose metabolism|IEA; GO:0006118|electron transport|IEA; GO:0016020|membrane|IEA

ACL00008398

unclassified

ACL00008399

putative acetylornithine deacetylase

Putative acetylornithine deacetylase related cluster

163

4e-11

38% (36/93)

Amino acid transport and metabolism

GO:0006508|proteolysis and peptidolysis|IEA; GO:0008237|metallopeptidase activity|IEA

ACL00008400

unclassified

ACL00008401

AL1B1

Aldehyde dehydrogenase X, mitochondrial precursor related cluster

256

6e-22

58% (47/80)

1.2.1.3

Energy production and conversion

GO:0004028|aldehyde dehydrogenase activity|NR; GO:0004029|aldehyde dehydrogenase (NAD) activity|IEA; GO:0005739|mitochondrion|IEA; GO:0005975|carbohydrate metabolism|NAS; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00008402

Unassigned protein

ACL00008403

multi-domain protein

117

8e-07

21% (35/160)

ACL00008404

unclassified

ACL00008405

unclassified

ACL00008406

C. elegans ankyrin-related unc-44 related cluster

164

9e-11

31% (42/132)

General function prediction only

GO:0005515|protein binding|IEA; GO:0007165|signal transduction|IEA

ACL00008407

unclassified

ACL00008408

unclassified

ACL00008409

Herpes_gp2 domain containing protein

120

6e-07

20% (51/243)

ACL00008410

multi-domain protein

120

5e-07

32% (29/90)

ACL00008411

unclassified

ACL00008412

zgc:63920

Cytochrome P450 8B1 related cluster

144

6e-09

46% (23/49)

GO:0004497|monooxygenase activity|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0005792|microsome|IEA; GO:0006118|electron transport|IEA; GO:0016021|integral to membrane|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00008413

Putative single stranded G-strand telomeric DNA-binding protein related cluster

123

2e-06

35% (24/67)

General function prediction only

GO:0003677|DNA binding|IEA; GO:0003723|RNA binding|IEA

ACL00008414

unclassified

ACL00008415

RPB5

DNA-directed RNA polymerase II 23 kDa polypeptide related cluster

375

9e-36

53% (68/127)

2.7.7.6

Transcription

GO:0003677|DNA binding|IEA; GO:0003899|DNA-directed RNA polymerase activity|IEA; GO:0003899|DNA-directed RNA polymerase activity|TAS; GO:0005515|protein binding|TAS; GO:0005634|nucleus|IEA; GO:0005665|DNA-directed RNA polymerase II, core complex|TAS; GO:0006350|transcription|IEA; GO:0006366|transcription from Pol II promoter|TAS; GO:0016740|transferase activity|IEA

ACL00008416

Actn2

Alpha-actinin 2 related cluster

198

4e-15

32% (48/148)

Cadherin-mediated cell adhesion Regulation of actin cytoskeleton

GO:0003779|actin binding|IEA; GO:0005509|calcium ion binding|IEA; GO:0005515|protein binding|IPI; GO:0005856|cytoskeleton|NAS; GO:0005884|actin filament|TAS; GO:0008307|structural constituent of muscle|TAS

ACL00008417

Lysine decarboxylase-like protein related cluster

296

2e-26

52% (55/105)

ACL00008418

unclassified

ACL00008419

unclassified

ACL00008420

unclassified

ACL00008421

unclassified

ACL00008422

draG

draG; dinitrogenase reductase activating glycohydrolase [EC:3.2.2.24]

117

5e-06

48% (21/43)

3.2.2.24

ACL00008423

ChSh domain containing protein

109

2e-07

41% (26/62)

ACL00008424

Usp39

Usp39; ubiquitin specific protease 39

340

1e-31

50% (62/122)

ACL00008425

unclassified

ACL00008426

unclassified

ACL00008427

Arfrp1

ARF-related protein 1 related cluster

386

1e-36

44% (80/180)

GO:0003924|GTPase activity|TAS; GO:0005525|GTP binding|IEA; GO:0005624|membrane fraction|TAS; GO:0005794|Golgi apparatus|IEA; GO:0007165|signal transduction|TAS; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00008428

unclassified

ACL00008429

unclassified

ACL00008430

unclassified

ACL00008431

fklB-1

Peptidyl-prolyl cis-trans isomerase, FKBP-type related cluster

402

1e-38

62% (77/124)

5.2.1.8

Posttranslational modification, protein turnover, chaperones

GO:0003755|peptidyl-prolyl cis-trans isomerase activity|IEA; GO:0006457|protein folding|IEA; GO:0016853|isomerase activity|IEA

ACL00008432

30S ribosomal protein S9 related cluster

222

8e-18

52% (48/91)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00008433

Putative phagocytic receptor 1b precursor related cluster

572

3e-58

59% (98/164)

GO:0004872|receptor activity|IEA; GO:0005215|transporter activity|IEA; GO:0006810|transport|IEA; GO:0016021|integral to membrane|IEA

ACL00008434

Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B related cluster

179

5e-13

44% (39/88)

6.3.5.-

Translation, ribosomal structure and biogenesis

GO:0006412|protein biosynthesis|IEA; GO:0016874|ligase activity|IEA; GO:0016884|carbon-nitrogen ligase activity, with glutamine as amido-N-donor|IEA; GO:0017068|glutamyl-tRNA(Gln) amidotransferase activity|IEA

ACL00008435

Unassigned protein

381

8e-36

44% (79/178)

ACL00008436

Unassigned protein

ACL00008437

Putative phosphate transporter related cluster

339

4e-31

42% (69/164)

GO:0005215|transporter activity|IEA; GO:0006810|transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA

ACL00008438

Dehydrogenase related cluster

201

2e-15

41% (48/116)

General function prediction only

GO:0006118|electron transport|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00008439

unclassified

ACL00008440

unclassified

ACL00008441

Unassigned protein

45

1e-06

47% (9/19)

ACL00008442

unclassified

ACL00008443

Ca++ ATPase related cluster

351

1e-32

47% (79/167)

Inorganic ion transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0005388|calcium-transporting ATPase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006812|cation transport|IEA; GO:0006816|calcium ion transport|IEA; GO:0008152|metabolism|IEA; GO:0015662|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|IEA; GO:0015992|proton transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016787|hydrolase activity|IEA; GO:0016820|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|IEA

ACL00008444

unclassified

ACL00008445

unclassified

ACL00008446

unclassified

ACL00008447

Unassigned protein

ACL00008448

RhoGEF domain containing protein

93

1e-05

21% (22/102)

ACL00008449

PTPLB

Protein tyrosine phosphatase-like protein PTPLB related cluster

245

3e-20

30% (58/192)

General function prediction only

GO:0016021|integral to membrane|TAS

ACL00008450

S4 domain, putative related cluster

436

2e-42

49% (82/166)

Translation, ribosomal structure and biogenesis

GO:0003723|RNA binding|IEA; GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00008451

unclassified

ACL00008452

Unassigned protein

182

3e-13

30% (39/129)

ACL00008453

Similar to Mus musculus (Mouse). similar to NCK-associated protein 1 related cluster

244

2e-20

39% (54/138)

ACL00008454

Unknown EST

70

4e-09

36% (12/33)

ACL00008455

unclassified

ACL00008456

Xpo1

Exportin 1 related cluster

333

2e-30

42% (68/160)

GO:0000059|protein-nucleus import, docking|IEA; GO:0005488|binding|IEA; GO:0005634|nucleus|IEA; GO:0005643|nuclear pore|IEA; GO:0005737|cytoplasm|IEA; GO:0006810|transport|IEA; GO:0008565|protein transporter activity|IEA; GO:0015031|protein transport|IEA

ACL00008457

unclassified

ACL00008458

ubiquitin-fold modifier 1 [Homo sapiens] ref|NP_080711.1| RIKEN cDNA 1810045K17 [Mus musculus] sp|P61960|BM02_HUMAN UPF0185 protein BM-002 sp|P61961|BM02_MOUSE UPF0185 protein BM-002 gb|AAF64258.1| BM-002 [Homo sapiens] dbj|BAB25255.1| unnamed protein product [Mus musculus] dbj|BAB25572.1| unnamed protein product [Mus musculus] gb|AAH05193.1| Ubiquitin-fold modifier 1 [Homo sapiens] dbj|BAC41011.1| unnamed protein product [Mus musculus] gb|AAH61065.1| 1810045K17Rik protein [Mus musculus] dbj|BAD15373.1| Ubiquitin-fold modifier 1 [Homo sapiens] emb|CAG33470.1| BM-002 [Homo sapiens]

290

2e-25

69% (53/76)

ACL00008459

transcriptional regulator, Sir2 family

335

1e-30

43% (80/184)

ACL00008460

unclassified

ACL00008461

unclassified

ACL00008462

Protamine_P1 domain containing protein

111

4e-06

51% (22/43)

ACL00008463

RP42

RP42 homolog related cluster

265

1e-22

31% (52/165)

ACL00008464

DUS10

Dual specificity protein phosphatase 10 related cluster

203

1e-15

44% (44/99)

3.1.3.16

Signal transduction mechanisms

GO:0004721|phosphoprotein phosphatase activity|IEA; GO:0004721|phosphoprotein phosphatase activity|TAS; GO:0005634|nucleus|IEA; GO:0005634|nucleus|TAS; GO:0005737|cytoplasm|TAS; GO:0006470|protein amino acid dephosphorylation|IEA; GO:0006470|protein amino acid dephosphorylation|TAS; GO:0006950|response to stress|TAS; GO:0007254|JNK cascade|TAS; GO:0008138|protein tyrosine/serine/threonine phosphatase activity|IEA; GO:0016787|hydrolase activity|IEA; GO:0017017|MAP kinase phosphatase activity|IEA

ACL00008465

Nucleotide exchange factor RasGEF I related cluster

346

3e-32

45% (70/155)

GO:0005085|guanyl-nucleotide exchange factor activity|IEA; GO:0007242|intracellular signaling cascade|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00008466

unclassified

ACL00008467

unclassified

ACL00008468

unclassified

ACL00008469

multi-domain protein

119

5e-07

25% (43/168)

ACL00008470

Unassigned protein

128

2e-06

45% (21/46)

ACL00008471

PH domain containing protein

132

2e-08

28% (30/107)

ACL00008472

Smyd5

SET domain protein 123 related cluster

120

8e-06

34% (41/118)

General function prediction only

ACL00008473

Unknown EST

126

1e-07

53% (26/49)

ACL00008474

Molecular chaperone Dd-TCP1 related cluster

637

9e-66

75% (123/164)

GO:0005524|ATP binding|IEA; GO:0006457|protein folding|IEA; GO:0051082|unfolded protein binding|IEA

ACL00008475

Unassigned protein

ACL00008476

unclassified

ACL00008477

BCKDHA

Branched-chain alpha-keto acid dehydrogenase E1-alpha subunit precursor related cluster

739

2e-77

63% (135/212)

1.2.4.4

Energy production and conversion

Valine, leucine and isoleucine degradation

GO:0008152|metabolism|IEA; GO:0016624|oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor|IEA

ACL00008478

unclassified

ACL00008479

Fumarate hydratase class I related cluster

571

3e-58

81% (103/127)

4.2.1.2

Energy production and conversion

Citrate cycle (TCA cycle) Reductive carboxylate cycle (CO2 fixation)

GO:0004333|fumarate hydratase activity|IEA; GO:0006091|generation of precursor metabolites and energy|IEA; GO:0016829|lyase activity|IEA

ACL00008480

SYC

Cysteinyl-tRNA synthetase related cluster

195

2e-14

28% (60/214)

6.1.1.16

Translation, ribosomal structure and biogenesis

GO:0000049|tRNA binding|TAS; GO:0004812|tRNA ligase activity|IEA; GO:0004817|cysteine-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0005625|soluble fraction|TAS; GO:0005737|cytoplasm|TAS; GO:0006412|protein biosynthesis|IEA; GO:0006412|protein biosynthesis|NR; GO:0006423|cysteinyl-tRNA aminoacylation|IEA; GO:0016874|ligase activity|IEA

ACL00008481

Putative receptor protein kinase related cluster

225

6e-18

39% (54/137)

GO:0004672|protein kinase activity|IEA; GO:0004872|receptor activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA

ACL00008482

ADA

Adenosine deaminase related cluster

243

2e-20

47% (49/104)

3.5.4.4

Nucleotide transport and metabolism

Purine metabolism

GO:0000034|adenine deaminase activity|IMP; GO:0004000|adenosine deaminase activity|IEA; GO:0005634|nucleus|IDA; GO:0005737|cytoplasm|IDA; GO:0009117|nucleotide metabolism|IEA; GO:0009168|purine ribonucleoside monophosphate biosynthesis|IEA; GO:0016787|hydrolase activity|IEA; GO:0019239|deaminase activity|IEA

ACL00008483

Probable long chain fatty-acid CoA ligase related cluster

575

2e-58

52% (112/212)

6.2.1.3

Fatty acid metabolism

GO:0003824|catalytic activity|IEA; GO:0004467|long-chain-fatty-acid-CoA ligase activity|IEA; GO:0008152|metabolism|IEA; GO:0016874|ligase activity|IEA

ACL00008484

unclassified

ACL00008485

THTM

3-mercaptopyruvate sulfurtransferase related cluster

75

7e-07

40% (20/49)

2.8.1.2

Cysteine metabolism

GO:0004792|thiosulfate sulfurtransferase activity|IEA; GO:0004792|thiosulfate sulfurtransferase activity|TAS; GO:0005759|mitochondrial matrix|NR; GO:0008272|sulfate transport|IEA; GO:0009440|cyanate catabolism|TAS; GO:0009636|response to toxin|TAS; GO:0016740|transferase activity|IEA; GO:0016784|3-mercaptopyruvate sulfurtransferase activity|IEA

ACL00008486

unclassified

ACL00008487

RhoGAP domain containing protein

193

2e-15

31% (41/130)

ACL00008488

AQR

AQR; likely ortholog of mouse aquarius

616

1e-63

68% (109/159)

ACL00008489

unclassified

ACL00008490

DCX domain containing protein

139

1e-10

36% (28/76)

ACL00008491

Aquaporin related cluster

170

9e-12

45% (33/73)

GO:0005215|transporter activity|IEA; GO:0006810|transport|IEA; GO:0015288|porin activity|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0019867|outer membrane|IEA

ACL00008492

unclassified

ACL00008493

Chromaffin granule amine transporter related cluster

150

2e-09

25% (41/162)

GO:0005215|transporter activity|IEA; GO:0006810|transport|IEA; GO:0006836|neurotransmitter transport|IEA; GO:0009573|ribulose bisphosphate carboxylase complex (sensu Magnoliophyta)|IEA; GO:0015238|drug transporter activity|IEA; GO:0015893|drug transport|IEA; GO:0015977|carbon utilization by fixation of carbon dioxide|IEA; GO:0016021|integral to membrane|IEA; GO:0016984|ribulose-bisphosphate carboxylase activity|IEA

ACL00008494

unclassified

ACL00008495

Steroid 5 alpha-reductase 2-like related cluster

153

2e-09

28% (37/130)

GO:0016021|integral to membrane|IEA

ACL00008496

FTHS

Formate--tetrahydrofolate ligase related cluster

503

2e-50

64% (98/152)

6.3.4.3

Nucleotide transport and metabolism

GO:0004329|formate-tetrahydrofolate ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006730|one-carbon compound metabolism|IEA; GO:0009396|folic acid and derivative biosynthesis|IEA; GO:0016874|ligase activity|IEA

ACL00008497

Galactose-1-phosphate uridylyltransferase related cluster

476

5e-47

46% (94/203)

Energy production and conversion

Galactose metabolism Nucleotide sugars metabolism

GO:0003982|UTP-hexose-1-phosphate uridylyltransferase activity|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0006012|galactose metabolism|IEA; GO:0008108|UDP-glucose-hexose-1-phosphate uridylyltransferase activity|IEA; GO:0016740|transferase activity|IEA; GO:0016779|nucleotidyltransferase activity|IEA

ACL00008498

Unassigned protein

237

1e-19

36% (47/128)

ACL00008499

unclassified

ACL00008500

Tymo_45kd_70kd domain containing protein

115

1e-06

24% (36/147)

ACL00008501

unclassified

ACL00008502

Mitochondrial import inner membrane translocase subunit TIM17 A related cluster

300

1e-26

49% (64/130)

Posttranslational modification, protein turnover, chaperones

GO:0005739|mitochondrion|IEA; GO:0005743|mitochondrial inner membrane|IEA; GO:0005744|mitochondrial inner membrane presequence translocase complex|IEA; GO:0006605|protein targeting|IEA; GO:0006810|transport|IEA; GO:0006886|intracellular protein transport|IEA; GO:0008565|protein transporter activity|IEA; GO:0015031|protein transport|IEA; GO:0015450|protein translocase activity|IEA; GO:0016021|integral to membrane|IEA; GO:0016021|integral to membrane|TAS; GO:0019866|inner membrane|IEA

ACL00008503

Gamma-tocopherol methyltransferase related cluster

289

2e-25

34% (66/190)

GO:0008168|methyltransferase activity|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00008504

unclassified

ACL00008505

Lig3

DNA ligase III isoform alpha related cluster

48

1e-09

52% (9/17)

6.5.1.1

GO:0003677|DNA binding|IEA; GO:0003910|DNA ligase (ATP) activity|IEA; GO:0005524|ATP binding|IEA; GO:0005622|intracellular|IEA; GO:0005634|nucleus|IEA; GO:0006260|DNA replication|IEA; GO:0006281|DNA repair|IEA; GO:0006310|DNA recombination|IEA; GO:0006974|response to DNA damage stimulus|IEA; GO:0016874|ligase activity|IEA

ACL00008506

unclassified

ACL00008507

RhoGEF domain containing protein

90

6e-06

40% (12/30)

ACL00008508

Histon acetyltransferase HAT1 related cluster

314

3e-28

42% (58/135)

GO:0008080|N-acetyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00008509

unclassified

ACL00008510

Unassigned protein

ACL00008511

unclassified

ACL00008512

GTP-binding protein Rheb homolog related cluster

175

2e-12

47% (32/68)

General function prediction only

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00008513

unclassified

ACL00008514

Dehydrogenase related cluster

254

2e-21

36% (64/177)

General function prediction only

GO:0004368|glycerol-3-phosphate dehydrogenase activity|IEA; GO:0006072|glycerol-3-phosphate metabolism|IEA; GO:0006118|electron transport|IEA; GO:0009331|glycerol-3-phosphate dehydrogenase complex|IEA; GO:0015036|disulfide oxidoreductase activity|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00008515

unclassified

ACL00008516

unclassified

ACL00008517

unclassified

ACL00008518

Putative hydrolase related cluster

354

7e-33

45% (78/173)

General function prediction only

GO:0005554|molecular_function unknown|IEA; GO:0006807|nitrogen compound metabolism|IEA; GO:0016787|hydrolase activity|IEA; GO:0016810|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|IEA

ACL00008519

unclassified

ACL00008520

unclassified

ACL00008521

Similar to Dictyostelium discoideum (Slime mold). developmental protein DG1037 related cluster

152

1e-27

56% (28/50)

ACL00008522

Srr

Serine racemase related cluster

324

8e-30

53% (60/112)

GO:0003824|catalytic activity|IEA; GO:0006520|amino acid metabolism|IEA; GO:0008152|metabolism|IEA

ACL00008523

unclassified

ACL00008524

unclassified

ACL00008525

unclassified

ACL00008526

unclassified

ACL00008527

PRKX

cAMP-dependent protein kinase A catalytic subunit related cluster

818

1e-86

68% (145/211)

2.7.1.37

Calcium signaling pathway MAPK signaling pathway Wnt signaling pathway

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00008528

unclassified

ACL00008529

Nitrilase 1 like protein related cluster

655

9e-68

58% (125/215)

GO:0006807|nitrogen compound metabolism|IEA; GO:0016810|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|IEA

ACL00008530

unclassified

ACL00008531

unclassified

ACL00008532

Similar to DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 related cluster

312

3e-28

48% (66/136)

GO:0003676|nucleic acid binding|IEA; GO:0005524|ATP binding|IEA; GO:0006139|nucleobase, nucleoside, nucleotide and nucleic acid metabolism|IEA; GO:0008026|ATP-dependent helicase activity|IEA; GO:0016818|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|IEA

ACL00008533

TT_ORF1 domain containing protein

112

1e-06

45% (26/57)

ACL00008534

FUM1

FUM1; Fumarase; converts fumaric acid to L-malic acid in the TCA cycle [EC:4.2.1.2] [KO:K01679]

214

3e-17

76% (38/50)

4.2.1.2

Energy production and conversion

Citrate cycle (TCA cycle) Reductive carboxylate cycle (CO2 fixation)

ACL00008535

[S] COG2135 Uncharacterized conserved protein

236

8e-20

40% (50/125)

Function unknown

ACL00008536

Dipeptidyl peptidase IV related cluster

70

2e-20

42% (15/35)

Amino acid transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0004274|dipeptidyl-peptidase IV activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008236|serine-type peptidase activity|IEA; GO:0016020|membrane|IEA

ACL00008537

SPPL3

Signal peptide peptidase-like 3 related cluster

259

7e-22

35% (54/151)

GO:0008233|peptidase activity|IEA; GO:0008717|D-alanyl-D-alanine endopeptidase activity|IEA; GO:0016021|integral to membrane|IEA; GO:0016787|hydrolase activity|IEA

ACL00008538

unclassified

ACL00008539

Atrophin-1 domain containing protein

110

5e-06

22% (36/157)

ACL00008540

F13B15.15; F-box family protein (FBL6)

90

2e-07

33% (18/53)

ACL00008541

multi-domain protein

146

5e-10

21% (48/221)

ACL00008542

unclassified

ACL00008543

unclassified

ACL00008544

DUF566 domain containing protein

122

3e-07

28% (46/159)

ACL00008545

multi-domain protein

307

1e-28

39% (58/148)

ACL00008546

ZnF_ZZ domain containing protein

91

3e-05

39% (13/33)

ACL00008547

unclassified

ACL00008548

unclassified

ACL00008549

Unassigned protein

ACL00008550

F20D23.18; cell cycle control protein-related

128

5e-07

35% (28/79)

ACL00008551

Unassigned protein

ACL00008552

NOX4

Kidney superoxide-producing NADPH oxidase related cluster

140

2e-08

34% (28/81)

GO:0000166|nucleotide binding|TAS; GO:0005489|electron transporter activity|TAS; GO:0006091|generation of precursor metabolites and energy|TAS; GO:0006118|electron transport|IEA; GO:0016020|membrane|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00008553

Putative enzyme with aminotransferase class-III domain protein related cluster

95

6e-19

70% (19/27)

2.6.1.-

Amino acid transport and metabolism

Aminophosphonate metabolism Caprolactam degradation Lysine biosynthesis

GO:0004222|metalloendopeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008483|transaminase activity|IEA; GO:0016740|transferase activity|IEA; GO:0030170|pyridoxal phosphate binding|IEA

ACL00008554

Acyl CoA:monoacylglycerol acyltransferase 2 related cluster

242

2e-20

36% (52/141)

GO:0008415|acyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00008555

unclassified

ACL00008556

PKN2

Probable serine/threonine protein kinase CPE1738 related cluster

120

7e-06

25% (35/138)

2.7.1.37

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0008658|penicillin binding|IEA; GO:0016740|transferase activity|IEA

ACL00008557

OCA2

OCA2; oculocutaneous albinism II (pink-eye dilution homolog, mouse)

235

1e-19

61% (44/72)

ACL00008558

unclassified

ACL00008559

Alpha-galactosidase related cluster

360

5e-34

56% (67/119)

GO:0004553|hydrolase activity, hydrolyzing O-glycosyl compounds|IEA; GO:0005975|carbohydrate metabolism|IEA

ACL00008560

unclassified

ACL00008561

MBK21.12; LEM3 (ligand-effect modulator 3) family protein / CDC50 family protein

347

1e-32

59% (64/107)

ACL00008562

[G] COG1640 4-alpha-glucanotransferase

167

2e-12

41% (34/82)

Carbohydrate transport and metabolism

ACL00008563

Alcohol dehydrogenase related cluster

127

5e-07

33% (23/69)

1.1.1.1

Bile acid biosynthesis Fatty acid metabolism Glycerolipid metabolism Glycolysis / Gluconeogenesis Tyrosine metabolism

GO:0004022|alcohol dehydrogenase activity|IEA; GO:0004024|alcohol dehydrogenase activity, zinc-dependent|IEA; GO:0008270|zinc ion binding|IEA

ACL00008564

APG6 domain containing protein

112

1e-06

59% (19/32)

ACL00008565

SH2 domain containing protein

109

6e-06

35% (22/62)

ACL00008566

Putative GTP-binding protein related cluster

186

7e-14

60% (33/55)

Signal transduction mechanisms

GO:0003746|translation elongation factor activity|IEA; GO:0005525|GTP binding|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006414|translational elongation|IEA

ACL00008567

unclassified

ACL00008568

pfkB type carbohydrate kinase protein family-like [Oryza sativa (japonica cultivar-group)] dbj|BAD10340.1| pfkB type carbohydrate kinase protein family-like [Oryza sativa (japonica cultivar-group)]

209

1e-15

33% (50/151)

ACL00008569

Putative formylglycinamide ribonucleotide amidotransferase related cluster

566

2e-57

57% (109/191)

Nucleotide transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0004642|phosphoribosylformylglycinamidine synthase activity|IEA; GO:0006189|'de novo' IMP biosynthesis|IEA; GO:0016740|transferase activity|IEA

ACL00008570

Putative carboxymethylenebutenolidase related cluster

477

4e-47

50% (86/171)

GO:0016787|hydrolase activity|IEA

ACL00008571

unclassified

ACL00008572

PH4H

Protein henna related cluster

522

2e-52

65% (90/138)

1.14.16.1

Phenylalanine, tyrosine and tryptophan biosynthesis Tryptophan metabolism

GO:0003824|catalytic activity|IEA; GO:0004497|monooxygenase activity|IEA; GO:0004505|phenylalanine 4-monooxygenase activity|IEA; GO:0004510|tryptophan 5-monooxygenase activity|IEA; GO:0005506|iron ion binding|IEA; GO:0006559|L-phenylalanine catabolism|IEA; GO:0006587|serotonin biosynthesis from tryptophan|IEA; GO:0008152|metabolism|IEA; GO:0009072|aromatic amino acid family metabolism|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016597|amino acid binding|IEA

ACL00008573

multi-domain protein

127

8e-08

26% (47/179)

ACL00008574

BPI2 domain containing protein

99

3e-06

20% (24/119)

ACL00008575

RAB domain containing protein

85

7e-05

32% (13/40)

ACL00008576

Cyclin-dependent kinase 8 related cluster

213

6e-17

86% (40/46)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00008577

Putative RNA methylase related cluster

206

1e-15

31% (60/193)

Replication, recombination and repair

GO:0005554|molecular_function unknown|IEA; GO:0008168|methyltransferase activity|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA

ACL00008578

multi-domain protein

135

1e-08

24% (49/198)

ACL00008579

TOPBP1

TOPBP1; topoisomerase (DNA) II binding protein

211

2e-16

35% (53/149)

ACL00008580

LEREPO4

LEREPO4; likely ortholog of mouse immediate early response, erythropoietin 4

491

6e-49

58% (99/169)

ACL00008581

unclassified

ACL00008582

unclassified

ACL00008583

transcriptional regulator

302

5e-27

47% (58/123)

ACL00008584

TT_ORF1 domain containing protein

113

2e-06

37% (25/67)

ACL00008585

66 kDa stress protein related cluster

270

1e-23

64% (50/77)

ACL00008586

Similar to Arabidopsis thaliana (Mouse-ear cress). putative NADH dehydrogenase 10.5K chain related cluster

240

5e-20

45% (44/97)

1.6.5.3 1.6.99.3

Oxidative phosphorylation

ACL00008587

unclassified

ACL00008588

Unassigned protein

145

1e-08

36% (33/91)

ACL00008589

unclassified

ACL00008590

Unknown EST

111

1e-05

42% (23/54)

ACL00008591

comEB

Putative deoxycytidylate deaminase related cluster

122

5e-06

36% (30/83)

3.5.4.12

Pyrimidine metabolism Type II secretion system

GO:0008270|zinc ion binding|IEA; GO:0016787|hydrolase activity|IEA

ACL00008592

Putative pre-mRNA splicing factor ATP-dependent RNA helicase related cluster

686

2e-71

73% (117/160)

Replication, recombination and repair

GO:0000398|nuclear mRNA splicing, via spliceosome|IEA; GO:0003676|nucleic acid binding|IEA; GO:0003723|RNA binding|IEA; GO:0004386|helicase activity|IEA; GO:0005524|ATP binding|IEA; GO:0005634|nucleus|IEA; GO:0006397|mRNA processing|IEA; GO:0008026|ATP-dependent helicase activity|IEA

ACL00008593

unclassified

ACL00008594

Polyubiquitin related cluster

142

2e-08

53% (29/54)

ACL00008595

unclassified

ACL00008596

unclassified

ACL00008597

unclassified

ACL00008598

Putative PHOSPHOGLYCERIDE transfer protein related cluster

205

1e-15

36% (46/125)

ACL00008599

MGC54796

Similar to mesenchymal stem cell protein DSCD75 related cluster

300

1e-26

43% (69/160)

ACL00008600

rpoA

Probable DNA-directed RNA polymerase alpha chain related cluster

139

7e-08

37% (33/87)

2.7.7.6

GO:0003677|DNA binding|IEA; GO:0003899|DNA-directed RNA polymerase activity|IEA; GO:0005488|binding|IEA; GO:0006350|transcription|IEA; GO:0016740|transferase activity|IEA; GO:0016779|nucleotidyltransferase activity|IEA

ACL00008601

unclassified

ACL00008602

RPF1

RNA processing factor 1 related cluster

544

4e-55

63% (103/163)

ACL00008603

Syntaxin 22 related cluster

287

4e-25

35% (73/204)

Intracellular trafficking, secretion, and vesicular transport

GO:0006810|transport|IEA; GO:0015031|protein transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA

ACL00008604

Myosin I heavy chain kinase related cluster

154

8e-10

41% (27/65)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00008605

unclassified

ACL00008606

unclassified

ACL00008607

RPA5

DNA-directed RNA polymerase I 40 kDa polypeptide related cluster

618

2e-63

52% (126/238)

2.7.7.6

Transcription

GO:0003677|DNA binding|IEA; GO:0003899|DNA-directed RNA polymerase activity|IEA; GO:0003899|DNA-directed RNA polymerase activity|TAS; GO:0005634|nucleus|IEA; GO:0005736|DNA-directed RNA polymerase I complex|TAS; GO:0006350|transcription|IEA; GO:0006360|transcription from Pol I promoter|TAS; GO:0016740|transferase activity|IEA; GO:0046983|protein dimerization activity|IEA

ACL00008608

Archease related cluster

399

2e-38

55% (78/140)

ACL00008609

Nucleolar RNA helicase II related cluster

203

2e-15

33% (51/154)

GO:0003676|nucleic acid binding|IEA; GO:0003723|RNA binding|IEA; GO:0004004|ATP-dependent RNA helicase activity|TAS; GO:0004386|helicase activity|IEA; GO:0005524|ATP binding|IEA; GO:0005634|nucleus|IEA; GO:0005730|nucleolus|TAS; GO:0008026|ATP-dependent helicase activity|IEA

ACL00008610

Phosphatidylglycerophosphate synthase related cluster

444

3e-43

36% (95/260)

Lipid transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0008152|metabolism|IEA

ACL00008611

unclassified

ACL00008612

Related to transcriptional regulator protein SPT6 related cluster

296

4e-26

31% (73/229)

Transcription

GO:0003723|RNA binding|IEA; GO:0007242|intracellular signaling cascade|IEA

ACL00008613

STE20-telated kinase DPAK1 related cluster

518

7e-52

52% (101/192)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA

ACL00008614

multi-domain protein

136

6e-09

29% (50/170)

ACL00008615

unclassified

ACL00008616

Histidine kinase DhkJ related cluster

112

8e-16

24% (39/157)

Signal transduction mechanisms

GO:0000155|two-component sensor molecule activity|IEA; GO:0000156|two-component response regulator activity|IEA; GO:0000160|two-component signal transduction system (phosphorelay)|IEA; GO:0003677|DNA binding|IEA; GO:0004871|signal transducer activity|IEA; GO:0005524|ATP binding|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0007165|signal transduction|IEA; GO:0007600|sensory perception|IEA; GO:0016020|membrane|IEA; GO:0016301|kinase activity|IEA; GO:0016310|phosphorylation|IEA; GO:0016772|transferase activity, transferring phosphorus-containing groups|IEA

ACL00008617

Probable mitochondrial chaperone BCS1 related cluster

273

1e-23

35% (64/179)

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0005739|mitochondrion|IEA; GO:0006457|protein folding|IEA; GO:0016021|integral to membrane|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA; GO:0051082|unfolded protein binding|IEA

ACL00008618

unclassified

ACL00008619

F-LANa

F-LANa; carcinoma related gene

93

1e-29

41% (20/48)

ACL00008620

unclassified

ACL00008621

Putative zinc finger protein related cluster

660

2e-68

63% (124/196)

GO:0003676|nucleic acid binding|IEA; GO:0008033|tRNA processing|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0050660|FAD binding|IEA

ACL00008622

Protein kinase, putative related cluster

179

6e-13

30% (47/153)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0004713|protein-tyrosine kinase activity|IEA; GO:0004871|signal transducer activity|IEA; GO:0005524|ATP binding|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0007165|signal transduction|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00008623

Unassigned protein

ACL00008624

Metal-activated pyridoxal enzyme related cluster

230

2e-18

33% (75/221)

GO:0008784|alanine racemase activity|IEA; GO:0030170|pyridoxal phosphate binding|IEA

ACL00008625

Aoc3

Diamine oxidase related cluster

265

1e-22

30% (63/208)

GO:0005507|copper ion binding|IEA; GO:0008131|amine oxidase activity|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00008626

unclassified

ACL00008627

NADE

Putative glutamine-dependent NAD(+) synthetase related cluster

584

1e-59

55% (118/211)

6.3.5.1

Coenzyme transport and metabolism

Glutamate metabolism Nicotinate and nicotinamide metabolism

GO:0003952|NAD+ synthase (glutamine-hydrolyzing) activity|IDA; GO:0003952|NAD+ synthase (glutamine-hydrolyzing) activity|IEA; GO:0005524|ATP binding|IEA; GO:0005634|nucleus|IDA; GO:0005737|cytoplasm|IDA; GO:0006807|nitrogen compound metabolism|IEA; GO:0009435|NAD biosynthesis|IEA; GO:0016810|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|IEA; GO:0016811|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|IDA; GO:0016874|ligase activity|IEA

ACL00008628

unclassified

ACL00008629

Putative alpha-coat protein related cluster

334

1e-30

44% (75/169)

GO:0005198|structural molecule activity|IEA; GO:0006886|intracellular protein transport|IEA; GO:0008565|protein transporter activity|IEA; GO:0019028|viral capsid|IEA

ACL00008630

unclassified

ACL00008631

unclassified

ACL00008632

Pathogenesis-related protein PR-6 type related cluster

123

2e-06

57% (23/40)

GO:0004867|serine-type endopeptidase inhibitor activity|IEA; GO:0009611|response to wounding|IEA

ACL00008633

ADCK1

ADCK1; aarF domain containing kinase 1

138

4e-08

29% (38/128)

ACL00008634

pccA

Propionyl-CoA carboxylase alpha chain, mitochondrial related cluster

437

6e-43

57% (80/139)

6.4.1.3

Lipid transport and metabolism

Propanoate metabolism Valine, leucine and isoleucine degradation

GO:0005524|ATP binding|IEA; GO:0008152|metabolism|IEA; GO:0009374|biotin binding|IEA; GO:0016874|ligase activity|IEA

ACL00008635

Unassigned protein

ACL00008636

PMA1

Probable plasma membrane ATPase related cluster

618

2e-63

61% (122/200)

3.6.3.6

Inorganic ion transport and metabolism

GO:0000287|magnesium ion binding|IEA; GO:0003824|catalytic activity|IEA; GO:0005524|ATP binding|IEA; GO:0006812|cation transport|IEA; GO:0008152|metabolism|IEA; GO:0008553|hydrogen-exporting ATPase activity, phosphorylative mechanism|IEA; GO:0015078|hydrogen ion transporter activity|IEA; GO:0015662|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|IEA; GO:0015992|proton transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016787|hydrolase activity|IEA; GO:0016820|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|IEA; GO:0016887|ATPase activity|IEA

ACL00008637

TBC1 domain family protein C22orf4 related cluster

187

1e-13

30% (42/139)

ACL00008638

sthA

Probable soluble pyridine nucleotide transhydrogenase related cluster

342

2e-31

59% (67/113)

1.6.1.1

Nicotinate and nicotinamide metabolism

ACL00008639

multi-domain protein

110

7e-06

25% (34/136)

ACL00008640

unclassified

ACL00008641

xpt

Xanthine phosphoribosyltransferase related cluster

402

1e-38

51% (83/161)

2.4.2.-

Nucleotide transport and metabolism

GO:0009116|nucleoside metabolism|IEA; GO:0016740|transferase activity|IEA; GO:0016757|transferase activity, transferring glycosyl groups|IEA; GO:0016763|transferase activity, transferring pentosyl groups|IEA; GO:0043101|purine salvage|IEA; GO:0046110|xanthine metabolism|IEA

ACL00008642

Unassigned protein

ACL00008643

Trim9

Tripartite motif protein 9 related cluster

155

7e-10

34% (43/126)

GO:0000151|ubiquitin ligase complex|IEA; GO:0004842|ubiquitin-protein ligase activity|IEA; GO:0005515|protein binding|IPI; GO:0005622|intracellular|IEA; GO:0005737|cytoplasm|IDA; GO:0008270|zinc ion binding|IEA; GO:0016567|protein ubiquitination|IEA

ACL00008644

unclassified

ACL00008645

SETB1

Histone-lysine N-methyltransferase, H3 lysine-9 specific 4 related cluster

172

9e-12

43% (36/83)

2.1.1.43

GO:0003676|nucleic acid binding|IEA; GO:0003677|DNA binding|IEA; GO:0005634|nucleus|IEA; GO:0008168|methyltransferase activity|IEA; GO:0008270|zinc ion binding|IEA; GO:0016568|chromatin modification|IEA; GO:0016740|transferase activity|IEA; GO:0018024|histone-lysine N-methyltransferase activity|IEA

ACL00008646

Unassigned protein

158

1e-10

31% (36/116)

ACL00008647

Putative zinc transporter related cluster

67

7e-06

38% (14/36)

GO:0006812|cation transport|IEA; GO:0008324|cation transporter activity|IEA; GO:0016020|membrane|IEA

ACL00008648

unclassified

ACL00008649

unclassified

ACL00008650

Vesicle transport-related protein related cluster

228

2e-18

38% (49/126)

ACL00008651

unclassified

ACL00008652

unclassified

ACL00008653

unclassified

ACL00008654

unclassified

ACL00008655

unclassified

ACL00008656

ACSA

Acetyl-coenzyme A synthetase related cluster

373

5e-81

69% (79/114)

6.2.1.1

Lipid transport and metabolism

Glycolysis / Gluconeogenesis Propanoate metabolism Pyruvate metabolism Reductive carboxylate cycle (CO2 fixation)

GO:0003824|catalytic activity|IEA; GO:0003987|acetate-CoA ligase activity|IEA; GO:0006935|chemotaxis|IEA; GO:0008152|metabolism|IEA; GO:0016874|ligase activity|IEA; GO:0019427|acetyl-CoA biosynthesis from acetate|IEA

ACL00008657

unclassified

ACL00008658

Unassigned protein

ACL00008659

Conjugation stage-specific protein related cluster

193

2e-14

41% (34/82)

GO:0003677|DNA binding|IEA; GO:0003899|DNA-directed RNA polymerase activity|IEA; GO:0005634|nucleus|IEA; GO:0006350|transcription|IEA; GO:0016740|transferase activity|IEA; GO:0046983|protein dimerization activity|IEA

ACL00008660

Interferon-related developmental regulator 1 related cluster

128

1e-06

33% (36/106)

GO:0005488|binding|IEA; GO:0007518|myoblast cell fate determination|TAS

ACL00008661

F22F7.13; acyl-CoA binding family protein

186

2e-13

28% (56/196)

ACL00008662

unclassified

ACL00008663

unclassified

ACL00008664

unclassified

ACL00008665

FBOX domain containing protein

96

1e-05

32% (15/46)

ACL00008666

unclassified

ACL00008667

unclassified

ACL00008668

[O] COG5539 Predicted cysteine protease (OTU family)

159

2e-11

37% (31/82)

Posttranslational modification, protein turnover, chaperones

ACL00008669

unclassified

ACL00008670

multi-domain protein

138

2e-10

31% (31/100)

ACL00008671

multi-domain protein

140

2e-09

44% (31/70)

ACL00008672

unclassified

ACL00008673

Protein kinase ERK2 related cluster

446

5e-44

75% (84/112)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00008674

unclassified

ACL00008675

zgc:56097

Similar to splicing factor 3a, subunit 2, 66kDa related cluster

196

5e-15

67% (36/53)

RNA processing and modification

GO:0003676|nucleic acid binding|IEA; GO:0005634|nucleus|IEA; GO:0008270|zinc ion binding|IEA

ACL00008676

unclassified

ACL00008677

unclassified

ACL00008678

multi-domain protein

139

3e-09

19% (37/187)

ACL00008679

unclassified

ACL00008680

t_SNARE domain containing protein

104

1e-06

24% (16/66)

ACL00008681

Type 5 serine/threonine phosphatase related cluster

657

4e-68

69% (117/169)

3.1.3.16

Signal transduction mechanisms

GO:0004629|phospholipase C activity|IEA; GO:0004721|phosphoprotein phosphatase activity|IEA; GO:0005488|binding|IEA; GO:0005634|nucleus|IEA; GO:0005737|cytoplasm|IEA; GO:0006470|protein amino acid dephosphorylation|IEA; GO:0007165|signal transduction|IEA; GO:0007242|intracellular signaling cascade|IEA; GO:0016787|hydrolase activity|IEA

ACL00008682

unclassified

ACL00008683

unclassified

ACL00008684

Putative peroxisomal membrane carrier protein related cluster

418

3e-40

37% (90/239)

GO:0005488|binding|IEA; GO:0006810|transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA

ACL00008685

VanY domain containing protein

117

5e-07

33% (25/75)

ACL00008686

unclassified

ACL00008687

unclassified

ACL00008688

Zinc finger DHHC domain containing protein 6 related cluster

235

4e-19

53% (35/66)

General function prediction only

GO:0016021|integral to membrane|IEA; GO:0046872|metal ion binding|IEA

ACL00008689

Podocalyxin domain containing protein

115

2e-06

17% (30/172)

ACL00008690

Unassigned protein

185

3e-13

41% (43/104)

ACL00008691

Putative PIRIN-like protein related cluster

132

2e-07

35% (31/88)

General function prediction only

ACL00008692

unclassified

ACL00008693

Pi-transporter homologue A-1 related cluster

226

6e-18

32% (55/167)

GO:0005215|transporter activity|IEA; GO:0006810|transport|IEA; GO:0016021|integral to membrane|IEA

ACL00008694

Splicing factor-like protein related cluster

252

5e-21

42% (52/122)

GO:0003676|nucleic acid binding|IEA; GO:0003723|RNA binding|IEA

ACL00008695

multi-domain protein

112

4e-06

48% (27/56)

ACL00008696

PH domain containing protein

158

2e-11

27% (27/100)

ACL00008697

unclassified

ACL00008698

unclassified

ACL00008699

Unknown EST

49

5e-06

71% (10/14)

ACL00008700

unclassified

ACL00008701

RNA recognition motif, putative related cluster

156

7e-10

29% (28/96)

GO:0003723|RNA binding|IEA

ACL00008702

DNA replication licensing factor MCM8 related cluster

268

1e-62

83% (49/59)

Replication, recombination and repair

GO:0003677|DNA binding|IEA; GO:0005524|ATP binding|IEA; GO:0006260|DNA replication|IEA; GO:0006270|DNA replication initiation|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0007049|cell cycle|IEA; GO:0008094|DNA-dependent ATPase activity|IEA

ACL00008703

unclassified

ACL00008704

unclassified

ACL00008705

Structural maintenance of chromosomes (SMC)-like protein related cluster

522

2e-52

62% (105/168)

GO:0005524|ATP binding|IEA; GO:0005634|nucleus|IEA; GO:0007001|chromosome organization and biogenesis (sensu Eukaryota)|IEA; GO:0016887|ATPase activity|IEA

ACL00008706

Catalase related cluster

187

9e-14

37% (44/117)

1.11.1.6

Inorganic ion transport and metabolism

Methane metabolism Tryptophan metabolism

GO:0004096|catalase activity|IEA; GO:0004601|peroxidase activity|IEA; GO:0006118|electron transport|IEA; GO:0006979|response to oxidative stress|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00008707

multi-domain protein

118

1e-06

25% (46/184)

ACL00008708

unclassified

ACL00008709

50S ribosomal protein L33 related cluster

120

3e-06

52% (25/48)

Translation, ribosomal structure and biogenesis

GO:0000049|tRNA binding|IEA; GO:0003723|RNA binding|IEA; GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0019843|rRNA binding|IEA

ACL00008710

[T] COG5409 EXS domain-containing protein

236

1e-19

28% (63/218)

Signal transduction mechanisms

ACL00008711

unclassified

ACL00008712

unclassified

ACL00008713

Beige protein homolog related cluster

159

4e-62

74% (29/39)

ACL00008714

multi-domain protein

124

2e-07

19% (57/299)

ACL00008715

PANE

Putative 2-dehydropantoate 2-reductase related cluster

137

6e-08

48% (28/58)

1.1.1.169

Coenzyme transport and metabolism

Pantothenate and CoA biosynthesis

GO:0006206|pyrimidine base metabolism|IEA; GO:0008677|2-dehydropantoate 2-reductase activity|IEA; GO:0015940|pantothenate biosynthesis|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00008716

unclassified

ACL00008717

T7N9.15; glycine-rich protein

124

7e-07

37% (23/62)

ACL00008718

act-2

Actin 7 related cluster

299

1e-26

37% (64/171)

Cytoskeleton

GO:0005198|structural molecule activity|IEA; GO:0005200|structural constituent of cytoskeleton|IEA; GO:0015629|actin cytoskeleton|IEA

ACL00008719

zgc:56454

Similar to yolk sac gene 2 related cluster

431

1e-41

43% (91/208)

ACL00008720

Zinc-finger protein zpr1 related cluster

286

4e-25

36% (61/165)

General function prediction only

GO:0005515|protein binding|IEA; GO:0005634|nucleus|IEA; GO:0008270|zinc ion binding|IEA

ACL00008721

Unknown EST

67

5e-06

48% (14/29)

ACL00008722

LOC312670

Adiponectin receptor protein 2 related cluster

188

4e-14

40% (38/94)

GO:0004872|receptor activity|IEA; GO:0006629|lipid metabolism|IEA; GO:0006631|fatty acid metabolism|IEA; GO:0009755|hormone-mediated signaling|ISS; GO:0016021|integral to membrane|IEA; GO:0016021|integral to membrane|ISS; GO:0019395|fatty acid oxidation|ISS; GO:0042562|hormone binding|ISS

ACL00008723

Myosin II heavy chain, non muscle related cluster

185

1e-13

42% (38/89)

Cytoskeleton

GO:0003774|motor activity|IEA; GO:0003779|actin binding|IEA; GO:0005516|calmodulin binding|IEA; GO:0005524|ATP binding|IEA; GO:0016459|myosin|IEA

ACL00008724

F22K18.110; ubiquitin-associated (UBA)/TS-N domain-containing protein / octicosapeptide/Phox/Bemp1 (PB1) domain-containing protein

169

2e-11

35% (41/114)

ACL00008725

Leucine zipper-EF-hand containing transmembrane protein 1 related cluster

397

1e-37

38% (105/271)

GO:0005739|mitochondrion|IDA; GO:0016021|integral to membrane|IEA; GO:0016021|integral to membrane|TAS

ACL00008726

pepP

Xaa-Pro aminopeptidase related cluster

346

6e-32

37% (83/222)

3.4.11.9

Amino acid transport and metabolism

GO:0004177|aminopeptidase activity|IEA; GO:0004239|methionyl aminopeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008233|peptidase activity|IEA; GO:0008235|metalloexopeptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00008727

Protein kinase 2 related cluster

624

2e-64

77% (122/158)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016740|transferase activity|IEA

ACL00008728

Cabc1

Chaperone-activity of bc1 complex-like, mitochondrial precursor related cluster

561

6e-57

56% (100/177)

GO:0005739|mitochondrion|IEA; GO:0006457|protein folding|IEA; GO:0051082|unfolded protein binding|IEA

ACL00008729

Thaumatin-like protein precursor related cluster

142

1e-08

41% (30/72)

ACL00008730

unclassified

ACL00008731

unclassified

ACL00008732

FtsJ domain containing protein

123

1e-07

29% (29/97)

ACL00008733

Similar to Dictyostelium discoideum (Slime mold). CIGB protein related cluster

120

2e-20

65% (19/29)

GO:0000151|ubiquitin ligase complex|IEA; GO:0004842|ubiquitin-protein ligase activity|IEA; GO:0008270|zinc ion binding|IEA; GO:0016567|protein ubiquitination|IEA

ACL00008734

unclassified

ACL00008735

SET family protein related cluster

197

1e-14

40% (44/109)

ACL00008736

unclassified

ACL00008737

Similar to TATA box binding protein (TBP)-associated factor, RNA polymerase II, I, 28kD related cluster

165

2e-11

53% (28/52)

Transcription

Basal transcription factors

GO:0003677|DNA binding|IEA; GO:0003700|transcription factor activity|IEA; GO:0003743|translation initiation factor activity|IEA; GO:0005634|nucleus|IEA; GO:0045449|regulation of transcription|IEA

ACL00008738

CG6033

CG6033; downstream of receptor kinase [KO:K04364]

131

4e-07

27% (32/117)

Jak-STAT signaling pathway

ACL00008739

unclassified

ACL00008740

Arch_ATPase domain containing protein

118

9e-07

24% (45/181)

ACL00008741

unclassified

ACL00008742

multi-domain protein

121

3e-07

20% (27/129)

ACL00008743

unclassified

ACL00008744

Alkylated DNA repair protein related cluster

128

4e-07

55% (25/45)

Replication, recombination and repair

ACL00008745

PPP3CA

Serine/threonine protein phosphatase calcineurin A related cluster

460

2e-45

55% (88/158)

3.1.3.16

Signal transduction mechanisms

Amyotrophic lateral sclerosis (ALS) Apoptosis Calcium signaling pathway MAPK signaling pathway Wnt signaling pathway

GO:0016787|hydrolase activity|IEA

ACL00008746

unclassified

ACL00008747

KYNU

Kynureninase related cluster

212

1e-16

37% (49/131)

3.7.1.3

Amino acid transport and metabolism

Tryptophan metabolism

GO:0005737|cytoplasm|IEA; GO:0006569|tryptophan catabolism|IEA; GO:0006569|tryptophan catabolism|NR; GO:0008233|peptidase activity|TAS; GO:0009435|NAD biosynthesis|IEA; GO:0016787|hydrolase activity|IEA; GO:0019363|pyridine nucleotide biosynthesis|IEA; GO:0030170|pyridoxal phosphate binding|IEA; GO:0030429|kynureninase activity|IEA

ACL00008748

Unassigned protein

137

7e-08

34% (32/94)

ACL00008749

RPB9

DNA-directed RNA polymerase II 14.5 kDa polypeptide related cluster

190

3e-14

47% (35/73)

2.7.7.6

Transcription

Purine metabolism Pyrimidine metabolism RNA polymerase

GO:0003677|DNA binding|IEA; GO:0003700|transcription factor activity|IEA; GO:0003899|DNA-directed RNA polymerase activity|IEA; GO:0003899|DNA-directed RNA polymerase activity|TAS; GO:0005634|nucleus|IEA; GO:0005665|DNA-directed RNA polymerase II, core complex|NR; GO:0006350|transcription|IEA; GO:0006354|RNA elongation|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006366|transcription from Pol II promoter|TAS; GO:0008270|zinc ion binding|TAS; GO:0016740|transferase activity|IEA

ACL00008750

AOF

Amine oxidase [flavin-containing] related cluster

250

4e-21

48% (47/96)

1.4.3.4

Amino acid transport and metabolism

GO:0005739|mitochondrion|IEA; GO:0006118|electron transport|IEA; GO:0008131|amine oxidase activity|IEA; GO:0016021|integral to membrane|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00008751

unclassified

ACL00008752

unclassified

ACL00008753

Sugar_transport domain containing protein

112

4e-06

25% (18/71)

ACL00008754

SYN2

Synapsin s-syn-long related cluster

211

2e-16

33% (52/153)

GO:0007269|neurotransmitter secretion|IEA; GO:0008021|synaptic vesicle|IEA

ACL00008755

unclassified

ACL00008756

multi-domain protein

116

1e-06

22% (34/154)

ACL00008757

LGUL

Lactoylglutathione lyase related cluster

627

1e-64

72% (114/158)

4.4.1.5

Amino acid transport and metabolism

GO:0004462|lactoylglutathione lyase activity|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0016829|lyase activity|IEA

ACL00008758

multi-domain protein

133

2e-08

23% (50/209)

ACL00008759

unclassified

ACL00008760

unclassified

ACL00008761

unclassified

ACL00008762

unclassified

ACL00008763

Herpes_BLLF1 domain containing protein

115

2e-06

22% (43/194)

ACL00008764

unclassified

ACL00008765

unclassified

ACL00008766

KIF5B

Kinesin heavy chain related cluster

195

2e-14

49% (41/83)

GO:0003774|motor activity|IEA; GO:0005524|ATP binding|IEA; GO:0005875|microtubule associated complex|IEA

ACL00008767

Putative ATP(GTP)-binding protein related cluster

286

2e-25

53% (52/97)

GO:0005524|ATP binding|IEA; GO:0005554|molecular_function unknown|IEA

ACL00008768

PIGT

GPI transamidase component PIG-T precursor related cluster

121

3e-06

60% (23/38)

Glycosylphosphatidylinositol(GPI)-anchor biosynthesis

GO:0005783|endoplasmic reticulum|IEA; GO:0016021|integral to membrane|IEA; GO:0042765|GPI-anchor transamidase complex|IEA

ACL00008769

unclassified

ACL00008770

unclassified

ACL00008771

unclassified

ACL00008772

unclassified

ACL00008773

Chaperonin containing TCP-1 delta subunit related cluster

215

3e-17

66% (41/62)

Posttranslational modification, protein turnover, chaperones

GO:0005524|ATP binding|IEA; GO:0006457|protein folding|IEA; GO:0051082|unfolded protein binding|IEA

ACL00008774

T18K17.15; eukaryotic translation initiation factor-related

297

3e-26

38% (56/144)

ACL00008775

Dinitrogenase reductase activating glycohydrolase related cluster

121

9e-06

28% (53/187)

GO:0016787|hydrolase activity|IEA

ACL00008776

unclassified

ACL00008777

unclassified

ACL00008778

Gats

GATS protein related cluster

178

1e-12

32% (48/148)

ACL00008779

unclassified

ACL00008780

Probable ribosomal large subunit pseudouridine synthase C protein related cluster

206

1e-15

33% (55/162)

Translation, ribosomal structure and biogenesis

GO:0003723|RNA binding|IEA; GO:0004730|pseudouridylate synthase activity|IEA; GO:0006396|RNA processing|IEA; GO:0009982|pseudouridine synthase activity|IEA; GO:0016829|lyase activity|IEA

ACL00008781

B561 domain containing protein

175

8e-15

21% (29/138)

ACL00008782

DnaJ domain containing protein

109

9e-06

35% (24/68)

ACL00008783

unclassified

ACL00008784

unclassified

ACL00008785

unclassified

ACL00008786

TT_ORF1 domain containing protein

108

7e-06

40% (27/67)

ACL00008787

MPPB

Mitochondrial processing peptidase beta subunit, mitochondrial precursor related cluster

649

5e-67

56% (128/225)

3.4.24.64

General function prediction only

GO:0004222|metalloendopeptidase activity|IEA; GO:0004240|mitochondrial processing peptidase activity|IEA; GO:0005739|mitochondrion|IEA; GO:0005739|mitochondrion|NR; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008233|peptidase activity|NR; GO:0008237|metallopeptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00008788

unclassified

ACL00008789

Cgl1058

Phosphoglycerate mutase/fructose-2,6-bisphosphatase related cluster

183

6e-13

26% (60/224)

5.4.2.1

Carbohydrate transport and metabolism

Glycolysis / Gluconeogenesis

GO:0003824|catalytic activity|IEA; GO:0004619|phosphoglycerate mutase activity|IEA; GO:0008152|metabolism|IEA; GO:0016853|isomerase activity|IEA

ACL00008790

multi-domain protein

110

3e-06

47% (19/40)

ACL00008791

Unassigned protein

ACL00008792

unclassified

ACL00008793

unclassified

ACL00008794

unclassified

ACL00008795

zgc:55762

Similar to serologically defined breast cancer antigen 84 related cluster

266

8e-23

42% (58/138)

ACL00008796

[P] COG1226 Kef-type K+ transport systems, predicted NAD-binding component

122

1e-06

30% (27/89)

Inorganic ion transport and metabolism

ACL00008797

Putative ATP /GTP binding protein related cluster

136

2e-07

28% (47/164)

General function prediction only

GO:0003924|GTPase activity|IEA; GO:0005525|GTP binding|IEA

ACL00008798

multi-domain protein

211

1e-17

37% (45/121)

ACL00008799

unclassified

ACL00008800

multi-domain protein

130

4e-08

23% (31/134)

ACL00008801

unclassified

ACL00008802

SEC24D

Protein transport protein Sec24D related cluster

252

6e-21

32% (69/211)

GO:0005515|protein binding|IEA; GO:0005554|molecular_function unknown|ND; GO:0005783|endoplasmic reticulum|IEA; GO:0005794|Golgi apparatus|IEA; GO:0006810|transport|IEA; GO:0006886|intracellular protein transport|IEA; GO:0006888|ER to Golgi transport|IEA; GO:0006888|ER to Golgi transport|NAS; GO:0015031|protein transport|IEA; GO:0030127|COPII vesicle coat|IEA; GO:0030127|COPII vesicle coat|NAS

ACL00008803

unclassified

ACL00008804

unclassified

ACL00008805

D123 domain containing protein

141

2e-09

30% (37/121)

ACL00008806

F-box/WD-repeat protein pof1 related cluster

134

2e-07

40% (33/81)

GO:0006512|ubiquitin cycle|IEA

ACL00008807

Unassigned protein

ACL00008808

DHHA2 domain containing protein

114

2e-06

24% (35/143)

ACL00008809

Itpk1

Similar to inositol 1,3,4-triphosphate 5/6 kinase related cluster

171

5e-12

31% (39/122)

ACL00008810

DEAD-box protein 52 related cluster

561

7e-57

50% (102/203)

GO:0003676|nucleic acid binding|IEA; GO:0003723|RNA binding|IEA; GO:0004386|helicase activity|IEA; GO:0005524|ATP binding|IEA; GO:0005634|nucleus|IEA; GO:0008026|ATP-dependent helicase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00008811

unclassified

ACL00008812

unclassified

ACL00008813

GCSP

Glycine dehydrogenase [decarboxylating] related cluster

579

4e-59

55% (103/186)

1.4.4.2

Amino acid transport and metabolism

Glycine, serine and threonine metabolism

GO:0004375|glycine dehydrogenase (decarboxylating) activity|IEA; GO:0005961|glycine dehydrogenase complex (decarboxylating)|IEA; GO:0006544|glycine metabolism|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0019464|glycine decarboxylation via glycine cleavage system|IEA

ACL00008814

unclassified

ACL00008815

MIJ24.190; pentatricopeptide (PPR) repeat-containing protein

193

3e-14

29% (57/192)

ACL00008816

SEC13L1

Protein transport protein sec13 homolog, WD domain containing related cluster

270

1e-23

52% (55/105)

General function prediction only

ACL00008817

unclassified

ACL00008818

DUF390 domain containing protein

116

1e-06

21% (50/231)

ACL00008819

Putative sulphate transporter related cluster

402

2e-38

41% (87/208)

Inorganic ion transport and metabolism

GO:0008271|sulfate porter activity|IEA; GO:0008272|sulfate transport|IEA; GO:0016020|membrane|IEA

ACL00008820

unclassified

ACL00008821

Calpain-like cysteine protease related cluster

127

1e-06

22% (41/179)

GO:0004198|calpain activity|IEA; GO:0005622|intracellular|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008233|peptidase activity|IEA

ACL00008822

SPRY domain-containing SOCS box protein SSB-3 [Mus musculus]

125

7e-06

25% (42/164)

ACL00008823

Exo_endo_phos domain containing protein

129

5e-08

18% (40/218)

ACL00008824

unclassified

ACL00008825

CG10641

EF-hand domain-containing protein CG10641 related cluster

161

1e-10

33% (38/114)

GO:0005509|calcium ion binding|IEA; GO:0007498|mesoderm development|IEP

ACL00008826

Putative TipD like WD repeat protein related cluster

337

8e-31

33% (80/237)

General function prediction only

ACL00008827

Histone acetyltransferase related cluster

126

7e-07

47% (19/40)

GO:0008080|N-acetyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00008828

unclassified

ACL00008829

Atpaf2

Atpaf2; ATP synthase mitochondrial F1 complex assembly factor 2

287

5e-25

31% (73/231)

Posttranslational modification, protein turnover, chaperones

ACL00008830

SCRK

Putative fructokinase related cluster

161

7e-11

32% (30/93)

2.7.1.4

GO:0008865|fructokinase activity|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00008831

unclassified

ACL00008832

4-hydroxybutyrate CoA-transferase related cluster

469

1e-46

60% (92/153)

Energy production and conversion

GO:0003824|catalytic activity|IEA; GO:0006084|acetyl-CoA metabolism|IEA

ACL00008833

multi-domain protein

152

8e-11

25% (40/155)

ACL00008834

Pxn

Paxillin related cluster

119

5e-06

36% (24/65)

Regulation of actin cytoskeleton

GO:0005515|protein binding|IEA; GO:0005515|protein binding|IPI; GO:0005856|cytoskeleton|IEA; GO:0005875|microtubule associated complex|TAS; GO:0006928|cell motility|NR; GO:0007155|cell adhesion|IEA; GO:0007155|cell adhesion|NAS; GO:0007160|cell-matrix adhesion|IEA; GO:0007165|signal transduction|TAS; GO:0007172|signal complex formation|TAS; GO:0008270|zinc ion binding|IEA

ACL00008835

multi-domain protein

138

5e-09

27% (55/199)

ACL00008836

Unknown EST

112

2e-06

73% (19/26)

ACL00008837

NAGB

Glucosamine-6-phosphate deaminase related cluster

230

4e-76

58% (45/77)

3.5.99.6

Carbohydrate transport and metabolism

Aminosugars metabolism

GO:0003824|catalytic activity|IEA; GO:0004342|glucosamine-6-phosphate deaminase activity|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0006044|N-acetylglucosamine metabolism|IEA; GO:0016787|hydrolase activity|IEA

ACL00008838

unclassified

ACL00008839

Ras GTPase-activating protein 1 related cluster

152

1e-09

30% (36/118)

GO:0005096|GTPase activator activity|IEA; GO:0005099|Ras GTPase activator activity|TAS; GO:0007242|intracellular signaling cascade|IEA; GO:0008151||IEA

ACL00008840

unclassified

ACL00008841

unclassified

ACL00008842

DGAT2

DGAT2; diacylglycerol O-acyltransferase homolog 2 (mouse)

140

1e-08

38% (33/85)

ACL00008843

unclassified

ACL00008844

unclassified

ACL00008845

Similar to Dictyostelium discoideum (Slime mold). protein tyrosine kinase related cluster

153

5e-10

38% (35/91)

ACL00008846

unclassified

ACL00008847

unclassified

ACL00008848

MccF-like protein related cluster

382

4e-36

40% (81/199)

Defense mechanisms

ACL00008849

VWA domain containing protein

133

5e-10

21% (39/181)

ACL00008850

unclassified

ACL00008851

Williams-Beuren syndrome critical region protein 21 related cluster

55

7e-13

30% (16/52)

GO:0003824|catalytic activity|IEA; GO:0006725|aromatic compound metabolism|IEA; GO:0016787|hydrolase activity|IEA

ACL00008852

unclassified

ACL00008853

F14D17.3; 2-phosphoglycerate kinase-related

90

2e-18

40% (18/45)

ACL00008854

Unassigned protein

ACL00008855

unclassified

ACL00008856

CG1676

Similar to cactin-related related cluster

126

2e-21

54% (18/33)

ACL00008857

unclassified

ACL00008858

unclassified

ACL00008859

Nucleolar RNA-associated protein alpha related cluster

69

3e-12

33% (13/39)

ACL00008860

unclassified

ACL00008861

unclassified

ACL00008862

Heat shock protein hsp70 homologue Pfhsp70-3 related cluster

152

7e-10

45% (32/70)

GO:0005524|ATP binding|IEA

ACL00008863

unclassified

ACL00008864

unclassified

ACL00008865

unclassified

ACL00008866

unclassified

ACL00008867

Unassigned protein

ACL00008868

Exportin-t domain containing protein

218

2e-18

24% (44/178)

ACL00008869

BRLZ domain containing protein

94

7e-06

26% (17/64)

ACL00008870

Kcnj15

ATP-sensitive inward rectifier potassium channel 15 related cluster

177

2e-12

44% (40/90)

GO:0005216|ion channel activity|IEA; GO:0005242|inward rectifier potassium channel activity|IEA; GO:0005242|inward rectifier potassium channel activity|TAS; GO:0005244|voltage-gated ion channel activity|IEA; GO:0005267|potassium channel activity|IEA; GO:0005624|membrane fraction|NR; GO:0005887|integral to plasma membrane|TAS; GO:0006811|ion transport|IEA; GO:0006813|potassium ion transport|IEA; GO:0006813|potassium ion transport|TAS; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA

ACL00008871

APC_basic domain containing protein

115

2e-06

29% (64/220)

ACL00008872

unclassified

ACL00008873

MaoC family protein related cluster

245

1e-20

50% (45/90)

GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00008874

unclassified

ACL00008875

DM6 domain containing protein

91

4e-05

21% (17/80)

ACL00008876

unclassified

ACL00008877

unclassified

ACL00008878

unclassified

ACL00008879

unclassified

ACL00008880

unclassified

ACL00008881

Ap4A phosphorylase II related cluster

242

6e-20

33% (62/186)

Nucleotide transport and metabolism

GO:0003877|ATP adenylyltransferase activity|IEA; GO:0005524|ATP binding|IEA

ACL00008882

Lrp16

Protein LRP16 related cluster

112

6e-27

48% (21/43)

GO:0005739|mitochondrion|IDA

ACL00008883

Tyr_Deacylase domain containing protein

197

5e-16

29% (33/111)

ACL00008884

unclassified

ACL00008885

HSPC176 related cluster

85

3e-11

46% (15/32)

ACL00008886

PAXILLIN-like protein related cluster

370

9e-35

41% (64/156)

GO:0008270|zinc ion binding|IEA

ACL00008887

ZnF_RBZ domain containing protein

103

1e-06

47% (11/23)

ACL00008888

MAOH

Malic enzyme, hydrogenosomal precursor related cluster

510

4e-51

58% (98/168)

1.1.1.40

Energy production and conversion

GO:0004470|malic enzyme activity|IEA; GO:0004473|malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|IEA; GO:0006108|malate metabolism|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0042566|hydrogenosome|IEA

ACL00008889

F7J7.70; transducin family protein / WD-40 repeat family protein

164

5e-11

33% (55/166)

ACL00008890

unclassified

ACL00008891

unclassified

ACL00008892

unclassified

ACL00008893

multi-domain protein

120

5e-07

45% (30/66)

ACL00008894

Coatomer alpha subunit related cluster

203

8e-16

50% (32/64)

GO:0006886|intracellular protein transport|IEA; GO:0008565|protein transporter activity|IEA

ACL00008895

unclassified

ACL00008896

Kinesin light chain related cluster

148

6e-09

35% (38/106)

GO:0003777|microtubule motor activity|IEA; GO:0005488|binding|IEA; GO:0005871|kinesin complex|IEA

ACL00008897

Unassigned protein

ACL00008898

unclassified

ACL00008899

Probable iron/ascorbate oxidoreductase related cluster

321

2e-29

39% (65/163)

GO:0005506|iron ion binding|IEA; GO:0016216|isopenicillin-N synthase activity|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0017000|antibiotic biosynthesis|IEA

ACL00008900

SNF8 like protein related cluster

111

2e-38

44% (22/50)

ACL00008901

unclassified

ACL00008902

Cyclic GMP-binding protein C related cluster

146

3e-09

40% (33/81)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0004713|protein-tyrosine kinase activity|IEA; GO:0005085|guanyl-nucleotide exchange factor activity|IEA; GO:0005524|ATP binding|IEA; GO:0005525|GTP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0007242|intracellular signaling cascade|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00008903

unclassified

ACL00008904

Unassigned protein

130

3e-07

48% (27/56)

ACL00008905

unclassified

ACL00008906

unclassified

ACL00008907

unclassified

ACL00008908

unclassified

ACL00008909

ADP_ribosyl_GH domain containing protein

150

1e-10

22% (47/211)

ACL00008910

Nuclear receptor-interacting factor related cluster

232

7e-19

36% (45/123)

GO:0003676|nucleic acid binding|IEA; GO:0004872|receptor activity|IEA; GO:0005634|nucleus|IEA; GO:0008270|zinc ion binding|IEA

ACL00008911

LSU rRNA; B.diminuta 23S rRNA gene.

54

8e-24

98% (57/58)

ACL00008912

unclassified

ACL00008913

unclassified

ACL00008914

unclassified

ACL00008915

Related to SCJ1 protein related cluster

308

8e-28

40% (66/161)

GO:0006457|protein folding|IEA; GO:0051082|unfolded protein binding|IEA

ACL00008916

UDP-sugar transporter UST74c related cluster

344

1e-31

35% (78/220)

GO:0001745|compound eye morphogenesis (sensu Endopterygota)|IMP; GO:0005351|sugar porter activity|IEA; GO:0005459|UDP-galactose transporter activity|IDA; GO:0005460|UDP-glucose transporter activity|IDA; GO:0005461|UDP-glucuronic acid transporter activity|IDA; GO:0005462|UDP-N-acetylglucosamine transporter activity|IDA; GO:0005464|UDP-xylose transporter activity|IDA; GO:0005794|Golgi apparatus|IEA; GO:0006810|transport|IEA; GO:0007423|sensory organ development|IMP; GO:0007447|imaginal disc pattern formation|IMP; GO:0007476|wing morphogenesis|IMP; GO:0009880|embryonic pattern specification|IMP; GO:0016021|integral to membrane|IEA

ACL00008917

Glycyl tRNA synthetase related cluster

182

2e-13

39% (37/93)

6.1.1.14

Translation, ribosomal structure and biogenesis

Aminoacyl-tRNA biosynthesis Glycine, serine and threonine metabolism

GO:0004812|tRNA ligase activity|IEA; GO:0004820|glycine-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006418|tRNA aminoacylation for protein translation|IEA; GO:0006426|glycyl-tRNA aminoacylation|IEA

ACL00008918

G6PDC

Glucose-6-phosphate 1-dehydrogenase, chloroplast precursor related cluster

143

8e-09

42% (29/68)

1.1.1.49

Glutathione metabolism Pentose phosphate pathway

GO:0004345|glucose-6-phosphate 1-dehydrogenase activity|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0006006|glucose metabolism|IEA; GO:0009507|chloroplast|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00008919

ADL254Wp

Nucleolar protein NOP2 related cluster

150

1e-09

65% (30/46)

GO:0005634|nucleus|IEA; GO:0005730|nucleolus|TAS; GO:0006364|rRNA processing|TAS; GO:0007046|ribosome biogenesis|IEA; GO:0008168|methyltransferase activity|IEA; GO:0008173|RNA methyltransferase activity|TAS; GO:0016740|transferase activity|IEA

ACL00008920

WD-repeat protein 2 related cluster

325

7e-30

44% (62/139)

General function prediction only

ACL00008921

unclassified

ACL00008922

unclassified

ACL00008923

Putative calcium binding transporter related cluster

148

4e-27

43% (28/65)

GO:0005488|binding|IEA; GO:0005509|calcium ion binding|IEA; GO:0005743|mitochondrial inner membrane|IEA; GO:0006810|transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA

ACL00008924

Vacuolar proton ATPase 100-kDa subunit related cluster

296

1e-26

51% (67/129)

Energy production and conversion

GO:0015992|proton transport|IEA; GO:0016020|membrane|IEA

ACL00008925

KTHY

Probable thymidylate kinase related cluster

210

2e-16

36% (49/135)

2.7.4.9

Nucleotide transport and metabolism

Pyrimidine metabolism

GO:0004798|thymidylate kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006233|dTDP biosynthesis|IEA; GO:0006235|dTTP biosynthesis|IEA; GO:0009165|nucleotide biosynthesis|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00008926

unclassified

ACL00008927

mlo2

Protein mlo2 related cluster

352

1e-32

42% (64/151)

GO:0003677|DNA binding|IEA; GO:0004842|ubiquitin-protein ligase activity|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006512|ubiquitin cycle|IEA

ACL00008928

unclassified

ACL00008929

Unassigned protein

ACL00008930

DeliriumA related cluster

123

2e-06

33% (30/90)

ACL00008931

unclassified

ACL00008932

Putative cytochrome P450 related cluster

174

2e-12

48% (32/66)

Secondary metabolites biosynthesis, transport and catabolism

GO:0004497|monooxygenase activity|IEA; GO:0006118|electron transport|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00008933

Sulfite oxidase, putative related cluster

113

3e-25

51% (22/43)

General function prediction only

GO:0006118|electron transport|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00008934

Probable aldehyde dehydrogenase (NAD+) DEPENDANT related cluster

118

6e-06

50% (21/42)

1.2.1.3

Energy production and conversion

1,2-Dichloroethane degradation Arginine and proline metabolism Ascorbate and aldarate metabolism Bile acid biosynthesis Butanoate metabolism Fatty acid metabolism Glycerolipid metabolism Glycolysis / Gluconeogenesis Histidine metabolism Limonene and pinene degradation Lysine degradation Propanoate metabolism Pyruvate metabolism Tryptophan metabolism Valine, leucine and isoleucine degradation beta-Alanine metabolism

GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00008935

Putative peroxisomal Ca-dependent solute carrier protein related cluster

141

1e-08

40% (31/77)

ACL00008936

Dual-specificity protein phosphatase-like protein related cluster

217

2e-17

42% (42/100)

Signal transduction mechanisms

GO:0004721|phosphoprotein phosphatase activity|IEA; GO:0006470|protein amino acid dephosphorylation|IEA; GO:0008138|protein tyrosine/serine/threonine phosphatase activity|IEA

ACL00008937

multi-domain protein

123

2e-07

27% (17/62)

ACL00008938

TRIP12

Thyroid receptor interacting protein 12 related cluster

362

8e-34

39% (83/208)

GO:0004842|ubiquitin-protein ligase activity|IEA; GO:0004842|ubiquitin-protein ligase activity|NAS; GO:0005488|binding|IEA; GO:0005622|intracellular|IEA; GO:0005829|cytosol|IEA; GO:0006464|protein modification|IEA; GO:0006512|ubiquitin cycle|IEA; GO:0008372|cellular_component unknown|ND; GO:0016567|protein ubiquitination|NAS; GO:0016874|ligase activity|IEA; GO:0046966|thyroid hormone receptor binding|IDA

ACL00008939

PRKAG1

5'-AMP-activated protein kinase, gamma-1 subunit related cluster

124

1e-06

33% (34/103)

GO:0004691|cAMP-dependent protein kinase activity|TAS; GO:0006468|protein amino acid phosphorylation|TAS; GO:0006633|fatty acid biosynthesis|IEA; GO:0007165|signal transduction|TAS; GO:0007283|spermatogenesis|TAS

ACL00008940

Unassigned protein

ACL00008941

unclassified

ACL00008942

Exosome complex exonuclease RRP43 related cluster

129

7e-23

62% (23/37)

GO:0000004|biological_process unknown|ND; GO:0000175|3'-5'-exoribonuclease activity|IEA; GO:0000178|exosome (RNase complex)|IEA; GO:0003723|RNA binding|IEA; GO:0004518|nuclease activity|IEA; GO:0004527|exonuclease activity|IEA; GO:0005554|molecular_function unknown|ND; GO:0005634|nucleus|IEA; GO:0006364|rRNA processing|IEA; GO:0006396|RNA processing|IEA; GO:0008372|cellular_component unknown|ND; GO:0016787|hydrolase activity|IEA

ACL00008943

Probable esterase/deacetylase related cluster

245

2e-20

40% (54/135)

Lipid transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0008152|metabolism|IEA; GO:0016787|hydrolase activity|IEA

ACL00008944

TCERG1

Similar to transcription elongation regulator 1 related cluster

256

1e-21

33% (59/174)

ACL00008945

unclassified

ACL00008946

Plasmodium_HRP domain containing protein

117

1e-06

29% (48/162)

ACL00008947

ADPP

ADP-ribose pyrophosphatase related cluster

338

2e-31

44% (66/150)

3.6.1.13

GO:0000287|magnesium ion binding|IEA; GO:0004636|phosphoribosyl-ATP diphosphatase activity|IDA; GO:0005634|nucleus|IDA; GO:0005737|cytoplasm|IDA; GO:0005739|mitochondrion|IDA; GO:0016787|hydrolase activity|IEA; GO:0030145|manganese ion binding|IEA; GO:0047631|ADP-ribose diphosphatase activity|IEA

ACL00008948

Osbpl1a

Oxysterol binding protein-related protein 1 related cluster

128

1e-06

45% (24/53)

GO:0005543|phospholipid binding|NAS; GO:0005622|intracellular|IC; GO:0006810|transport|IEA; GO:0006869|lipid transport|IEA; GO:0008202|steroid metabolism|IEA; GO:0008203|cholesterol metabolism|NAS; GO:0016192|vesicle-mediated transport|NAS

ACL00008949

unclassified

ACL00008950

unclassified

ACL00008951

unclassified

ACL00008952

unclassified

ACL00008953

unclassified

ACL00008954

unclassified

ACL00008955

unclassified

ACL00008956

similar to kinesin light chain

149

4e-09

34% (33/96)

ACL00008957

unclassified

ACL00008958

multi-domain protein

126

7e-08

41% (19/46)

ACL00008959

unclassified

ACL00008960

cyp2

Cytochrome P-450 cyp509A1 related cluster

59

1e-08

57% (11/19)

GO:0004497|monooxygenase activity|IEA; GO:0006118|electron transport|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00008961

unclassified

ACL00008962

unclassified

ACL00008963

unclassified

ACL00008964

Mastigoneme-like protein related cluster

135

8e-08

44% (26/59)

ACL00008965

unclassified

ACL00008966

Unknown EST

56

3e-06

51% (14/27)

ACL00008967

PLSC

1-acyl-sn-glycerol-3-phosphate acyltransferase related cluster

237

2e-19

33% (54/161)

2.3.1.51

Lipid transport and metabolism

GO:0003841|1-acylglycerol-3-phosphate O-acyltransferase activity|IEA; GO:0008152|metabolism|IEA; GO:0008415|acyltransferase activity|IEA; GO:0008654|phospholipid biosynthesis|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016740|transferase activity|IEA

ACL00008968

unclassified

ACL00008969

PFTA

Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit related cluster

78

6e-12

76% (13/17)

2.5.1.58

GO:0004659|prenyltransferase activity|IEA; GO:0004660|protein farnesyltransferase activity|TAS; GO:0004661|protein geranylgeranyltransferase activity|TAS; GO:0005737|cytoplasm|TAS; GO:0007179|transforming growth factor beta receptor signaling pathway|TAS; GO:0008318|protein prenyltransferase activity|IEA; GO:0016740|transferase activity|IEA; GO:0018346|protein amino acid prenylation|IEA; GO:0018347|protein amino acid farnesylation|TAS; GO:0018348|protein amino acid geranylgeranylation|TAS

ACL00008970

Unassigned protein

ACL00008971

unclassified

ACL00008972

unclassified

ACL00008973

unclassified

ACL00008974

MGC3794

MGC3794; putative MAPK activating protein

411

2e-39

41% (85/207)

ACL00008975

EKI1

Ethanolamine kinase related cluster

226

2e-18

39% (49/124)

2.7.1.82

Glycerolipid metabolism

GO:0004305|ethanolamine kinase activity|IEA; GO:0016301|kinase activity|IEA

ACL00008976

zf-UBP domain containing protein

111

3e-06

33% (15/45)

ACL00008977

unclassified

ACL00008978

unclassified

ACL00008979

unclassified

ACL00008980

FBXL2

FBXL2; F-box and leucine-rich repeat protein 2

178

2e-12

27% (54/193)

ACL00008981

SANT domain containing protein

92

2e-05

29% (14/47)

ACL00008982

Herpes_BLLF1 domain containing protein

112

3e-06

23% (37/158)

ACL00008983

unclassified

ACL00008984

T4O12.26; complex 1 family protein / LVR family protein

133

7e-08

48% (27/56)

ACL00008985

unclassified

ACL00008986

Aldh3a2

Aldehyde dehydrogenase family 3 related cluster

380

3e-36

52% (73/140)

1.2.1.3 1.2.1.5

Energy production and conversion

Arginine and proline metabolism Ascorbate and aldarate metabolism Bile acid biosynthesis Butanoate metabolism Fatty acid metabolism Glycerolipid metabolism Glycolysis / Gluconeogenesis Histidine metabolism Limonene and pinene degradation Lysine degradation Propanoate metabolism Pyruvate metabolism Tryptophan metabolism Valine, leucine and isoleucine degradation beta-Alanine metabolism

GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00008987

Unassigned protein

ACL00008988

CIRH1A

Cirhin related cluster

185

2e-13

33% (57/172)

GO:0005634|nucleus|IEA

ACL00008989

unclassified

ACL00008990

unclassified

ACL00008991

Protein tyrosine phosphatase related cluster

132

3e-07

37% (29/77)

Signal transduction mechanisms

GO:0004721|phosphoprotein phosphatase activity|IEA; GO:0006470|protein amino acid dephosphorylation|IEA; GO:0008138|protein tyrosine/serine/threonine phosphatase activity|IEA

ACL00008992

unclassified

ACL00008993

unclassified

ACL00008994

unclassified

ACL00008995

Peroxisomal targeting signal type 2 receptor related cluster

196

4e-52

54% (34/62)

GO:0004872|receptor activity|IEA

ACL00008996

unclassified

ACL00008997

RUFY1

RUN and FYVE domain containing protein 1 related cluster

178

2e-12

49% (29/59)

GO:0000151|ubiquitin ligase complex|IEA; GO:0004842|ubiquitin-protein ligase activity|IEA; GO:0008270|zinc ion binding|IEA; GO:0016567|protein ubiquitination|IEA

ACL00008998

unclassified

ACL00008999

unclassified

ACL00009000

unclassified

ACL00009001

Ankyrin repeat domain protein 10 related cluster

146

4e-09

38% (34/88)

General function prediction only

ACL00009002

unclassified

ACL00009003

Putative splicing factor related cluster

102

1e-14

56% (17/30)

GO:0003723|RNA binding|IEA; GO:0005634|nucleus|IEA; GO:0006397|mRNA processing|IEA

ACL00009004

Probable short-chain dehydrogenase related cluster

143

7e-09

63% (29/46)

General function prediction only

GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00009005

unclassified

ACL00009006

folate hydrolase homolog

144

3e-09

44% (29/65)

ACL00009007

unclassified

ACL00009008

Actr3

Actin-like protein 3 related cluster

186

8e-14

81% (35/43)

GO:0005198|structural molecule activity|IEA; GO:0005200|structural constituent of cytoskeleton|IEA; GO:0005856|cytoskeleton|IEA; GO:0015629|actin cytoskeleton|IEA

ACL00009009

unclassified

ACL00009010

unclassified

ACL00009011

TolA domain containing protein

107

6e-06

41% (24/58)

ACL00009012

unclassified

ACL00009013

unclassified

ACL00009014

unclassified

ACL00009015

unclassified

ACL00009016

Unassigned protein

165

2e-11

41% (37/89)

ACL00009017

MAP3K epsilon protein kinase related cluster

172

7e-43

59% (34/57)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0004713|protein-tyrosine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00009018

COMMD5

COMMD5; COMM domain containing 5

180

3e-13

60% (37/61)

ACL00009019

unclassified

ACL00009020

Ctbs

Similar to di-N-acetylchitobiase related cluster

111

2e-28

60% (20/33)

3.2.1.-

Aminosugars metabolism Glycosaminoglycan degradation Nucleotide sugars metabolism

GO:0003824|catalytic activity|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0008152|metabolism|IEA; GO:0016787|hydrolase activity|IEA

ACL00009021

unclassified

ACL00009022

UBACT domain containing protein

119

1e-07

56% (17/30)

ACL00009023

CG17299

CG17299; SNF4Agamma gene product from transcript CG17299-RC [EC:2.7.1.-]

135

1e-07

28% (39/135)

2.7.1.-

Benzoate degradation via CoA ligation Inositol phosphate metabolism Nicotinate and nicotinamide metabolism Starch and sucrose metabolism

ACL00009024

unclassified

ACL00009025

unclassified

ACL00009026

unclassified

ACL00009027

KIAA1416

Probable chromodomain-helicase-DNA-binding protein KIAA1416 related cluster

113

1e-39

65% (19/29)

GO:0000785|chromatin|IEA; GO:0003676|nucleic acid binding|IEA; GO:0003677|DNA binding|IEA; GO:0003682|chromatin binding|IEA; GO:0004386|helicase activity|IEA; GO:0005524|ATP binding|IEA; GO:0005634|nucleus|IEA; GO:0006333|chromatin assembly or disassembly|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0016568|chromatin modification|IEA; GO:0016787|hydrolase activity|IEA

ACL00009028

Pantoate_ligase domain containing protein

106

1e-06

69% (16/23)

ACL00009029

unclassified

ACL00009030

Guanine nucleotide exchange factor-like protein related cluster

227

2e-18

36% (49/134)

ACL00009031

unclassified

ACL00009032

unclassified

ACL00009033

[G] COG0063 Predicted sugar kinase

198

1e-15

33% (47/139)

Carbohydrate transport and metabolism

ACL00009034

MGLL

Monoglyceride lipase related cluster

134

8e-08

32% (39/120)

3.1.1.23

Glycerolipid metabolism

GO:0003824|catalytic activity|IEA; GO:0004759|serine esterase activity|IEA; GO:0006725|aromatic compound metabolism|IEA; GO:0016787|hydrolase activity|IEA; GO:0047372|acylglycerol lipase activity|IEA

ACL00009035

CG2358

Microsomal signal peptidase 21 kDa subunit related cluster

567

1e-57

73% (107/145)

3.4.-.-

Intracellular trafficking, secretion, and vesicular transport

Protein export

GO:0005783|endoplasmic reticulum|IEA; GO:0005792|microsome|IEA; GO:0006465|signal peptide processing|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008233|peptidase activity|IEA; GO:0008236|serine-type peptidase activity|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016787|hydrolase activity|IEA

ACL00009036

Metallo-beta-lactamase family protein related cluster

362

8e-34

40% (72/176)

ACL00009037

Txnrd1

Thioredoxin reductase 1 related cluster

364

2e-34

73% (70/95)

1.8.1.9

Pyrimidine metabolism

GO:0004791|thioredoxin-disulfide reductase activity|IDA; GO:0005737|cytoplasm|IEA; GO:0005829|cytosol|IDA; GO:0006118|electron transport|IEA; GO:0006125|thioredoxin pathway|IDA; GO:0015036|disulfide oxidoreductase activity|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016654|oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor|IEA; GO:0050660|FAD binding|IEA

ACL00009038

unclassified

ACL00009039

TLDc domain containing protein

158

7e-13

21% (37/175)

ACL00009040

F2K15.50; condensation domain-containing protein

130

5e-07

24% (47/190)

ACL00009041

unclassified

ACL00009042

unclassified

ACL00009043

unclassified

ACL00009044

unclassified

ACL00009045

unclassified

ACL00009046

Cytadhesin_P30 domain containing protein

120

4e-07

21% (39/179)

ACL00009047

Stam

STAM related cluster

149

2e-09

47% (26/55)

Jak-STAT signaling pathway

GO:0005070|SH3/SH2 adaptor protein activity|TAS; GO:0006886|intracellular protein transport|IEA; GO:0007165|signal transduction|TAS

ACL00009048

unclassified

ACL00009049

ALG2

Alpha-1,3-mannosyltransferase ALG2 related cluster

287

1e-25

49% (56/114)

2.4.1.132

N-Glycan biosynthesis

GO:0009058|biosynthesis|IEA; GO:0016021|integral to membrane|IEA; GO:0016740|transferase activity|IEA; GO:0016757|transferase activity, transferring glycosyl groups|IEA

ACL00009050

hemA

5-aminolevulinate synthase related cluster

54

5e-18

36% (9/25)

2.3.1.37

Glycine, serine and threonine metabolism

GO:0003824|catalytic activity|IEA; GO:0003870|5-aminolevulinate synthase activity|IEA; GO:0006783|heme biosynthesis|IEA; GO:0008415|acyltransferase activity|IEA; GO:0009058|biosynthesis|IEA; GO:0016740|transferase activity|IEA

ACL00009051

unclassified

ACL00009052

unclassified

ACL00009053

pab2

Putative poly(a) binding protein related cluster

321

2e-29

69% (57/82)

General function prediction only

GO:0003723|RNA binding|IEA

ACL00009054

Unknown EST

56

7e-06

75% (6/8)

ACL00009055

unclassified

ACL00009056

DUF850 domain containing protein

503

1e-51

50% (86/170)

ACL00009057

unclassified

ACL00009058

Nonhistone protein 6 related cluster

224

6e-18

53% (41/76)

GO:0000785|chromatin|IEA; GO:0003677|DNA binding|IEA; GO:0005634|nucleus|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA

ACL00009059

Unassigned protein

ACL00009060

unclassified

ACL00009061

unclassified

ACL00009062

unclassified

ACL00009063

unclassified

ACL00009064

Abhd4

Abhd4; abhydrolase domain containing 4

184

1e-13

56% (36/64)

ACL00009065

Herpes_gp2 domain containing protein

109

9e-06

22% (45/197)

ACL00009066

unclassified

ACL00009067

unclassified

ACL00009068

Actin-like protein 3 related cluster

112

1e-106

100% (23/23)

Cytoskeleton

GO:0005198|structural molecule activity|IEA; GO:0005200|structural constituent of cytoskeleton|IEA; GO:0005856|cytoskeleton|IEA; GO:0015629|actin cytoskeleton|IEA

ACL00009069

Putative spliceosomal protein related cluster

209

3e-52

72% (43/59)

GO:0003723|RNA binding|IEA

ACL00009070

unclassified

ACL00009071

Kpnb3

Importin beta-3 related cluster

263

1e-22

39% (54/138)

GO:0000059|protein-nucleus import, docking|IEA; GO:0005095|GTPase inhibitor activity|TAS; GO:0005488|binding|IEA; GO:0005634|nucleus|IEA; GO:0005634|nucleus|TAS; GO:0005643|nuclear pore|IEA; GO:0005643|nuclear pore|TAS; GO:0005737|cytoplasm|IEA; GO:0005737|cytoplasm|TAS; GO:0006607|NLS-bearing substrate-nucleus import|TAS; GO:0006810|transport|IEA; GO:0008139|nuclear localization sequence binding|NR; GO:0008536|RAN protein binding|TAS; GO:0008565|protein transporter activity|IEA; GO:0015031|protein transport|IEA

ACL00009072

unclassified

ACL00009073

unclassified

ACL00009074

FBXW7

F-box/WD-repeat protein 7 related cluster

325

1e-29

41% (56/134)

General function prediction only

Neurodegenerative Disorders Ubiquitin mediated proteolysis

GO:0005634|nucleus|IEA; GO:0006512|ubiquitin cycle|IEA

ACL00009075

BTB domain containing protein

90

3e-05

25% (14/56)

ACL00009076

unclassified

ACL00009077

Methylthioadenosine phosphorylase related cluster

334

1e-30

37% (78/206)

Nucleotide transport and metabolism

GO:0016763|transferase activity, transferring pentosyl groups|IEA

ACL00009078

Unassigned protein

68

1e-09

30% (15/49)

ACL00009079

unclassified

ACL00009080

unclassified

ACL00009081

Putative membrane protein related cluster

337

6e-31

40% (72/176)

General function prediction only

ACL00009082

Unknown EST

46

2e-07

64% (9/14)

ACL00009083

unclassified

ACL00009084

DNA repair and recombination protein RAD52 related cluster

145

4e-09

70% (29/41)

Replication, recombination and repair

GO:0005634|nucleus|IEA; GO:0006281|DNA repair|IEA; GO:0006310|DNA recombination|IEA

ACL00009085

Probable fatty acid elongase related cluster

51

2e-08

55% (10/18)

GO:0016021|integral to membrane|IEA

ACL00009086

unclassified

ACL00009087

HYES

Soluble epoxide hydrolase (SEH) related cluster

591

2e-60

51% (118/228)

3.3.2.3

General function prediction only

Tetrachloroethene degradation

GO:0003824|catalytic activity|IEA; GO:0004301|epoxide hydrolase activity|IEA; GO:0005737|cytoplasm|NR; GO:0005777|peroxisome|IEA; GO:0006725|aromatic compound metabolism|IEA; GO:0006805|xenobiotic metabolism|IEA; GO:0008152|metabolism|IEA; GO:0009636|response to toxin|IEA; GO:0016787|hydrolase activity|IEA; GO:0019439|aromatic compound catabolism|IEA

ACL00009088

unclassified

ACL00009089

unclassified

ACL00009090

unclassified

ACL00009091

TAR RNA loop binding protein related cluster

323

1e-29

59% (59/100)

GO:0003723|RNA binding|IEA; GO:0003723|RNA binding|TAS; GO:0005634|nucleus|TAS; GO:0006357|regulation of transcription from Pol II promoter|TAS; GO:0006396|RNA processing|IEA; GO:0008173|RNA methyltransferase activity|IEA

ACL00009092

Xenotropic and polytropic murine retrovirus receptor related cluster

149

2e-09

30% (40/132)

GO:0004872|receptor activity|IEA; GO:0004872|receptor activity|TAS; GO:0004888|transmembrane receptor activity|TAS; GO:0004930|G-protein coupled receptor activity|TAS; GO:0005886|plasma membrane|TAS; GO:0005887|integral to plasma membrane|TAS; GO:0007186|G-protein coupled receptor protein signaling pathway|TAS; GO:0016021|integral to membrane|IEA

ACL00009093

Unassigned protein

ACL00009094

Endonuclease related cluster

174

2e-12

41% (28/68)

GO:0003676|nucleic acid binding|IEA; GO:0004519|endonuclease activity|IEA; GO:0006308|DNA catabolism|IEA

ACL00009095

unclassified

ACL00009096

Nucleotide exchange factor RasGEF Q related cluster

145

5e-09

43% (31/71)

GO:0005085|guanyl-nucleotide exchange factor activity|IEA; GO:0007242|intracellular signaling cascade|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00009097

unclassified

ACL00009098

unclassified

ACL00009099

unclassified

ACL00009100

Tymo_45kd_70kd domain containing protein

106

9e-06

32% (28/87)

ACL00009101

unclassified

ACL00009102

unclassified

ACL00009103

unclassified

ACL00009104

DM6 domain containing protein

88

8e-05

27% (27/100)

ACL00009105

NUYM

NADH-ubiquinone oxidoreductase 18 kDa subunit, mitochondrial precursor related cluster

236

2e-19

45% (47/104)

1.6.5.3

Oxidative phosphorylation

GO:0003954|NADH dehydrogenase activity|IEA; GO:0005624|membrane fraction|TAS; GO:0005739|mitochondrion|IEA; GO:0006118|electron transport|IEA; GO:0006120|mitochondrial electron transport, NADH to ubiquinone|TAS; GO:0008137|NADH dehydrogenase (ubiquinone) activity|TAS; GO:0016491|oxidoreductase activity|IEA; GO:0016651|oxidoreductase activity, acting on NADH or NADPH|IEA

ACL00009106

TT_ORF1 domain containing protein

115

2e-06

30% (31/101)

ACL00009107

[R] COG2110 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1

103

2e-37

36% (18/50)

General function prediction only

ACL00009108

unclassified

ACL00009109

multi-domain protein

113

3e-06

23% (29/121)

ACL00009110

unclassified

ACL00009111

infB

Translation initiation factor IF-2 related cluster

137

5e-08

34% (33/96)

Translation, ribosomal structure and biogenesis

GO:0003743|translation initiation factor activity|IEA; GO:0003924|GTPase activity|IEA; GO:0005525|GTP binding|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006413|translational initiation|IEA

ACL00009112

[D] COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

162

1e-53

75% (31/41)

Cell cycle control, cell division, chromosome partitioning

ACL00009113

PCI domain containing protein

113

2e-06

22% (18/81)

ACL00009114

unclassified

ACL00009115

Putative PHOSPHOGLYCERIDE transfer protein related cluster

150

2e-22

33% (29/87)

ACL00009116

DM6 domain containing protein

87

1e-04

34% (31/90)

ACL00009117

unclassified

ACL00009118

unclassified

ACL00009119

DNA topoisomerase I related cluster

273

9e-24

54% (51/94)

GO:0003677|DNA binding|IEA; GO:0003917|DNA topoisomerase type I activity|IEA; GO:0006265|DNA topological change|IEA; GO:0006268|DNA unwinding|IEA; GO:0016853|isomerase activity|IEA

ACL00009120

Unassigned protein

ACL00009121

unclassified

ACL00009122

unclassified

ACL00009123

unclassified

ACL00009124

unclassified

ACL00009125

unclassified

ACL00009126

Unassigned protein

ACL00009127

unclassified

ACL00009128

unclassified

ACL00009129

unclassified

ACL00009130

RAD1

Similar to RAD1 homolog related cluster

52

7e-37

75% (9/12)

GO:0003684|damaged DNA binding|IEA; GO:0004527|exonuclease activity|IEA; GO:0005634|nucleus|IEA; GO:0006281|DNA repair|IEA

ACL00009131

Pre-mRNA cleavage complex II protein Clp1 related cluster

304

2e-27

43% (62/141)

RNA processing and modification

GO:0005524|ATP binding|IEA; GO:0005524|ATP binding|TAS; GO:0005525|GTP binding|TAS; GO:0005634|nucleus|IEA; GO:0006397|mRNA processing|IEA

ACL00009132

Ubiquitin-conjugating enzyme protein UbcC related cluster

290

1e-25

62% (54/86)

Posttranslational modification, protein turnover, chaperones

GO:0004840|ubiquitin conjugating enzyme activity|IEA; GO:0006464|protein modification|IEA; GO:0006512|ubiquitin cycle|IEA; GO:0016874|ligase activity|IEA

ACL00009133

KITH

Thymidine kinase, cytosolic related cluster

49

6e-42

60% (9/15)

2.7.1.21

Nucleotide transport and metabolism

Pyrimidine metabolism

GO:0004797|thymidine kinase activity|IEA; GO:0004797|thymidine kinase activity|TAS; GO:0005524|ATP binding|IEA; GO:0005737|cytoplasm|NR; GO:0006139|nucleobase, nucleoside, nucleotide and nucleic acid metabolism|TAS; GO:0006259|DNA metabolism|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00009134

PHS1

Glycogen phosphorylase 1 related cluster

405

3e-39

61% (76/123)

2.4.1.1

Carbohydrate transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0004645|phosphorylase activity|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0005977|glycogen metabolism|IEA; GO:0016740|transferase activity|IEA; GO:0016757|transferase activity, transferring glycosyl groups|IEA

ACL00009135

unclassified

ACL00009136

unclassified

ACL00009137

unclassified

ACL00009138

Glutaminyl tRNA synthetase related cluster

342

8e-32

65% (62/94)

Translation, ribosomal structure and biogenesis

GO:0004812|tRNA ligase activity|IEA; GO:0004818|glutamate-tRNA ligase activity|IEA; GO:0004819|glutamine-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006424|glutamyl-tRNA aminoacylation|IEA

ACL00009139

unclassified

ACL00009140

unclassified

ACL00009141

unclassified

ACL00009142

unclassified

ACL00009143

unclassified

ACL00009144

unclassified

ACL00009145

pxn

Paxillin related cluster

124

5e-11

34% (23/66)

GO:0008270|zinc ion binding|IEA

ACL00009146

multi-domain protein

160

8e-12

41% (28/67)

ACL00009147

DM6 domain containing protein

91

3e-05

28% (30/106)

ACL00009148

unclassified

ACL00009149

unclassified

ACL00009150

SOS1

Son of sevenless protein homolog 1 related cluster

321

4e-29

36% (64/176)

Integrin-mediated cell adhesion Jak-STAT signaling pathway MAPK signaling pathway Regulation of actin cytoskeleton

GO:0003677|DNA binding|IEA; GO:0005085|guanyl-nucleotide exchange factor activity|IEA; GO:0005088|Ras guanyl-nucleotide exchange factor activity|TAS; GO:0005089|Rho guanyl-nucleotide exchange factor activity|TAS; GO:0005100|Rho GTPase activator activity|TAS; GO:0007165|signal transduction|NAS; GO:0007242|intracellular signaling cascade|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0007265|Ras protein signal transduction|TAS

ACL00009151

CDC2H

CDC2-like serine/threonine-protein kinase CRP related cluster

210

1e-62

84% (39/46)

2.7.1.37

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016740|transferase activity|IEA

ACL00009152

unclassified

ACL00009153

F-box protein ZEITLUPE/FKF/LKP/ADAGIO family related cluster

135

1e-07

29% (36/124)

ACL00009154

DUF786 domain containing protein

248

5e-22

43% (39/89)

ACL00009155

unclassified

ACL00009156

unclassified

ACL00009157

Separation anxiety protein-like related cluster

436

1e-42

57% (80/139)

GO:0008080|N-acetyltransferase activity|IEA

ACL00009158

LOC312670

Adiponectin receptor protein 2 related cluster

215

6e-17

40% (45/110)

GO:0004872|receptor activity|IEA; GO:0006629|lipid metabolism|IEA; GO:0006631|fatty acid metabolism|IEA; GO:0009755|hormone-mediated signaling|ISS; GO:0016021|integral to membrane|IEA; GO:0016021|integral to membrane|ISS; GO:0019395|fatty acid oxidation|ISS; GO:0042562|hormone binding|ISS

ACL00009159

NIFIE14

Seven transmembrane domain protein related cluster

363

7e-34

37% (77/206)

GO:0016021|integral to membrane|IEA

ACL00009160

unclassified

ACL00009161

CG13922

Mitochondrial 39S ribosomal protein L46 related cluster

150

3e-09

26% (49/184)

GO:0003735|structural constituent of ribosome|IEA; GO:0005739|mitochondrion|IEA

ACL00009162

MMAB

Cob(I)alamin adenosyltransferase, mitochondrial precursor related cluster

489

2e-48

54% (101/185)

2.5.1.17

GO:0005739|mitochondrion|IEA; GO:0008817|cob(I)yrinic acid a,c-diamide adenosyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00009163

MASA

E-1 enzyme related cluster

371

4e-35

48% (80/164)

GO:0003824|catalytic activity|IEA; GO:0008152|metabolism|IEA

ACL00009164

MutT domain protein-like related cluster

145

8e-25

47% (28/59)

GO:0016787|hydrolase activity|IEA

ACL00009165

Putative DNA-binding protein related cluster

439

5e-43

61% (78/127)

GO:0003677|DNA binding|IEA; GO:0004840|ubiquitin conjugating enzyme activity|IEA; GO:0006464|protein modification|IEA; GO:0006512|ubiquitin cycle|IEA

ACL00009166

unclassified

ACL00009167

Menaquinone biosynthesis methyltransferase related cluster

135

1e-07

36% (39/108)

Coenzyme transport and metabolism

GO:0003723|RNA binding|IEA; GO:0005634|nucleus|IEA; GO:0006364|rRNA processing|IEA; GO:0008168|methyltransferase activity|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA

ACL00009168

Similar to Dictyostelium discoideum (Slime mold). ankyrin repeat containing protein related cluster

311

8e-28

37% (57/152)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00009169

unclassified

ACL00009170

unclassified

ACL00009171

S_TKc domain containing protein

97

9e-06

23% (30/126)

ACL00009172

Dipeptidyl aminopeptidase related cluster

101

1e-70

72% (18/25)

GO:0004177|aminopeptidase activity|IEA; GO:0004289|subtilase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA

ACL00009173

RPC62

RNA polymerase III subunit related cluster

345

9e-32

36% (82/224)

2.7.7.6

Purine metabolism Pyrimidine metabolism RNA polymerase

ACL00009174

Methyltransferase related cluster

255

3e-21

58% (50/85)

GO:0008168|methyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00009175

multi-domain protein

122

3e-07

20% (39/194)

ACL00009176

PUR9

Bifunctional purine biosynthesis protein purH related cluster

592

2e-60

52% (120/228)

2.1.2.3

Nucleotide transport and metabolism

One carbon pool by folate Purine metabolism

GO:0003824|catalytic activity|IEA; GO:0003937|IMP cyclohydrolase activity|IEA; GO:0004643|phosphoribosylaminoimidazolecarboxamide formyltransferase activity|IEA; GO:0006164|purine nucleotide biosynthesis|IEA; GO:0016740|transferase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00009177

Protamine_P1 domain containing protein

109

7e-06

52% (22/42)

ACL00009178

Aminopeptidase related cluster

226

5e-18

28% (66/231)

General function prediction only

GO:0004177|aminopeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00009179

Herpes_gp2 domain containing protein

111

4e-06

32% (32/99)

ACL00009180

Putative WD-40 repeat protein related cluster

224

8e-18

50% (41/82)

General function prediction only

ACL00009181

Similar to Oryctolagus cuniculus (Rabbit). acyloxyacyl hydrolase related cluster

437

1e-42

51% (81/158)

GO:0016787|hydrolase activity|IEA

ACL00009182

unclassified

ACL00009183

unclassified

ACL00009184

unclassified

ACL00009185

unclassified

ACL00009186

Unknown EST

88

1e-11

42% (17/40)

ACL00009187

unclassified

ACL00009188

Serine hydroxymethyltransferase related cluster

642

1e-66

78% (122/156)

2.1.2.1

Amino acid transport and metabolism

Cyanoamino acid metabolism Glycine, serine and threonine metabolism Lysine degradation Methane metabolism One carbon pool by folate

GO:0004372|glycine hydroxymethyltransferase activity|IEA; GO:0006544|glycine metabolism|IEA; GO:0006563|L-serine metabolism|IEA; GO:0006730|one-carbon compound metabolism|IEA; GO:0008168|methyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00009189

Loc192259

Phospholipase B related cluster

351

2e-32

40% (76/189)

GO:0003824|catalytic activity|IEA

ACL00009190

GLO2

Hydroxyacylglutathione hydrolase related cluster

671

1e-69

53% (127/236)

3.1.2.6

General function prediction only

Pyruvate metabolism

GO:0004416|hydroxyacylglutathione hydrolase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00009191

multi-domain protein

124

2e-07

23% (30/128)

ACL00009192

unclassified

ACL00009193

multi-domain protein

91

2e-05

12% (6/48)

ACL00009194

Putative xylanase related cluster

256

2e-21

31% (60/192)

GO:0003824|catalytic activity|IEA

ACL00009195

Herpes_gp2 domain containing protein

112

2e-06

26% (23/88)

ACL00009196

CG6194

CG6194; CG6194 gene product

57

4e-19

36% (8/22)

ACL00009197

unclassified

ACL00009198

Pyruvate kinase related cluster

493

6e-49

48% (98/203)

2.7.1.40

Carbohydrate transport and metabolism

Carbon fixation Glycolysis / Gluconeogenesis Purine metabolism Pyruvate metabolism

GO:0000287|magnesium ion binding|IEA; GO:0004743|pyruvate kinase activity|IEA; GO:0006096|glycolysis|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00009199

unclassified

ACL00009200

unclassified

ACL00009201

EIF4EL3

Eukaryotic translation initiation factor 4E type 3 related cluster

134

3e-07

31% (28/88)

GO:0000339|RNA cap binding|TAS; GO:0003723|RNA binding|IEA; GO:0003743|translation initiation factor activity|IEA; GO:0005737|cytoplasm|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006413|translational initiation|IEA; GO:0006417|regulation of protein biosynthesis|IEA; GO:0006445|regulation of translation|IEA; GO:0006445|regulation of translation|TAS; GO:0008135|translation factor activity, nucleic acid binding|TAS

ACL00009202

unclassified

ACL00009203

unclassified

ACL00009204

Multifunctional aminoacyl-tRNA ligase-like protein related cluster

134

8e-08

60% (25/41)

6.1.1.15

Aminoacyl-tRNA biosynthesis Arginine and proline metabolism

GO:0004812|tRNA ligase activity|IEA; GO:0004827|proline-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0005737|cytoplasm|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006418|tRNA aminoacylation for protein translation|IEA; GO:0006433|prolyl-tRNA aminoacylation|IEA; GO:0016874|ligase activity|IEA

ACL00009205

psmd12

Similar to proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12 related cluster

496

3e-49

48% (99/206)

Posttranslational modification, protein turnover, chaperones

GO:0005829|cytosol|IEA

ACL00009206

methyltransfer with N-terminal ankyrin repeats [Cryptosporidium parvum]

196

3e-14

35% (62/174)

General function prediction only

ACL00009207

unclassified

ACL00009208

Microcephalin related cluster

188

1e-13

32% (49/149)

GO:0005622|intracellular|IEA

ACL00009209

Atrn

Attractin precursor related cluster

127

2e-06

28% (36/126)

GO:0004872|receptor activity|IEA; GO:0004872|receptor activity|TAS; GO:0005198|structural molecule activity|IEA; GO:0005529|sugar binding|IEA; GO:0005615|extracellular space|TAS; GO:0005886|plasma membrane|NAS; GO:0005887|integral to plasma membrane|TAS; GO:0006954|inflammatory response|IEA; GO:0007275|development|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA

ACL00009210

unclassified

ACL00009211

FBOX domain containing protein

88

1e-04

36% (15/41)

ACL00009212

CG9998

Splicing factor U2AF 50 kDa subunit related cluster

372

7e-35

52% (74/140)

GO:0000398|nuclear mRNA splicing, via spliceosome|IEA; GO:0003723|RNA binding|IEA; GO:0005634|nucleus|IEA; GO:0005686|snRNP U2|TAS; GO:0006397|mRNA processing|IEA; GO:0008187|poly-pyrimidine tract binding|IDA; GO:0008248|pre-mRNA splicing factor activity|IMP

ACL00009213

glycerophosphoryl diester phosphodiesterase

135

1e-07

29% (34/114)

Energy production and conversion

ACL00009214

Sugt1

Suppressor of G2 allele of SKP1 homolog related cluster

265

6e-23

48% (61/127)

General function prediction only

GO:0005488|binding|IEA; GO:0006512|ubiquitin cycle|IEA

ACL00009215

Glycosyl hydrolase, family 65 related cluster

585

2e-59

45% (119/259)

Carbohydrate transport and metabolism

GO:0016787|hydrolase activity|IEA

ACL00009216

multi-domain protein

138

4e-09

29% (21/71)

ACL00009217

unclassified

ACL00009218

Similar to PH (Pleckstrin homology) domain related cluster

192

3e-14

47% (29/61)

GO:0008270|zinc ion binding|IEA

ACL00009219

95 kDa retinoblastoma protein binding protein homolog related cluster

177

1e-12

44% (31/70)

GO:0000151|ubiquitin ligase complex|IEA; GO:0004842|ubiquitin-protein ligase activity|IEA; GO:0008270|zinc ion binding|IEA; GO:0016567|protein ubiquitination|IEA

ACL00009220

unclassified

ACL00009221

unclassified

ACL00009222

Sortilin, putative related cluster

270

4e-23

32% (63/194)

GO:0006886|intracellular protein transport|IEA; GO:0008565|protein transporter activity|IEA; GO:0016020|membrane|IEA

ACL00009223

Peroxisomal targeting signal type 2 receptor related cluster

201

4e-15

32% (60/185)

GO:0004872|receptor activity|IEA

ACL00009224

Unassigned protein

ACL00009225

WD REPEAT PROTEIN

WD repeat protein, periodic tryptophan protein 1 homolog related cluster

420

2e-40

33% (82/242)

General function prediction only

ACL00009226

unclassified

ACL00009227

RPIA

Ribose 5-phosphate isomerase related cluster

556

3e-56

52% (120/227)

5.3.1.6

Carbohydrate transport and metabolism

Carbon fixation Pentose phosphate pathway

GO:0004751|ribose-5-phosphate isomerase activity|IEA; GO:0004751|ribose-5-phosphate isomerase activity|IMP; GO:0005634|nucleus|IDA; GO:0005737|cytoplasm|IDA; GO:0006098|pentose-phosphate shunt|IGI; GO:0009052|pentose-phosphate shunt, non-oxidative branch|IEA; GO:0016853|isomerase activity|IEA

ACL00009228

unclassified

ACL00009229

unclassified

ACL00009230

Importin alpha 1 subunit related cluster

116

1e-05

40% (23/57)

GO:0005488|binding|IEA; GO:0006810|transport|IEA; GO:0015031|protein transport|IEA

ACL00009231

PSN domain containing protein

85

1e-04

10% (5/46)

ACL00009232

IHPK3

IHPK3; inositol hexaphosphate kinase 3

172

4e-12

36% (34/94)

ACL00009233

Putative chromatin remodeling protein SYD related cluster

185

1e-13

49% (36/73)

GO:0003676|nucleic acid binding|IEA; GO:0003677|DNA binding|IEA; GO:0004386|helicase activity|IEA; GO:0005524|ATP binding|IEA

ACL00009234

DHX29

DEAH (Asp-Glu-Ala-His) box polypeptide 29 related cluster

179

9e-13

32% (33/103)

GO:0003676|nucleic acid binding|IEA; GO:0004386|helicase activity|IEA; GO:0005524|ATP binding|IEA; GO:0008026|ATP-dependent helicase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00009235

unclassified

ACL00009236

WD40 domain containing protein

87

1e-05

57% (12/21)

ACL00009237

GPT

UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase related cluster

585

1e-59

58% (121/208)

2.7.8.15

Cell wall/membrane/envelope biogenesis

GO:0003824|catalytic activity|IEA; GO:0003975|UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0006629|lipid metabolism|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016740|transferase activity|IEA; GO:0016757|transferase activity, transferring glycosyl groups|IEA

ACL00009238

unclassified

ACL00009239

unclassified

ACL00009240

EFh domain containing protein

92

1e-05

45% (11/24)

ACL00009241

Tetratricopeptide repeat family protein related cluster

293

8e-26

34% (65/190)

General function prediction only

GO:0003777|microtubule motor activity|IEA; GO:0005488|binding|IEA; GO:0005871|kinesin complex|IEA

ACL00009242

Putative RNA helicase related cluster

483

6e-48

51% (96/187)

Replication, recombination and repair

GO:0003676|nucleic acid binding|IEA; GO:0004386|helicase activity|IEA; GO:0005524|ATP binding|IEA; GO:0008026|ATP-dependent helicase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00009243

unclassified

ACL00009244

Similar to Dictyostelium discoideum (Slime mold). adenylyl cyclase related cluster

127

7e-07

34% (46/134)

ACL00009245

Ubiquitin-conjugating enzyme E2Q related cluster

216

3e-17

41% (49/117)

GO:0004840|ubiquitin conjugating enzyme activity|IEA; GO:0006464|protein modification|IEA; GO:0006512|ubiquitin cycle|IEA

ACL00009246

CDC2H

CDC2-like serine/threonine-protein kinase CRP related cluster

169

7e-12

49% (28/57)

2.7.1.37

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016740|transferase activity|IEA

ACL00009247

dapE

Succinyl-diaminopimelate desuccinylase related cluster

197

5e-15

34% (53/154)

3.5.1.18

Amino acid transport and metabolism

Lysine biosynthesis

GO:0006508|proteolysis and peptidolysis|IEA; GO:0008237|metallopeptidase activity|IEA; GO:0009014|succinyl-diaminopimelate desuccinylase activity|IEA; GO:0009089|lysine biosynthesis via diaminopimelate|IEA

ACL00009248

DHX8

ATP-dependent helicase DHX8 related cluster

236

4e-43

52% (47/90)

Replication, recombination and repair

GO:0000398|nuclear mRNA splicing, via spliceosome|IEA; GO:0003676|nucleic acid binding|IEA; GO:0003723|RNA binding|IEA; GO:0004004|ATP-dependent RNA helicase activity|TAS; GO:0004386|helicase activity|IEA; GO:0005524|ATP binding|IEA; GO:0005634|nucleus|IEA; GO:0005634|nucleus|TAS; GO:0005681|spliceosome complex|TAS; GO:0006396|RNA processing|TAS; GO:0006397|mRNA processing|IEA; GO:0008026|ATP-dependent helicase activity|IEA; GO:0008248|pre-mRNA splicing factor activity|TAS; GO:0008380|RNA splicing|TAS

ACL00009249

unclassified

ACL00009250

unclassified

ACL00009251

unclassified

ACL00009252

Unknown EST

114

2e-06

46% (25/54)

ACL00009253

Putative flavonol synthase-like protein related cluster

316

1e-28

48% (57/117)

General function prediction only

GO:0005506|iron ion binding|IEA; GO:0016216|isopenicillin-N synthase activity|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0017000|antibiotic biosynthesis|IEA

ACL00009254

GNTK

[G] COG3265 Gluconate kinase

254

2e-22

40% (54/133)

Carbohydrate transport and metabolism

ACL00009255

STE20-like kinase MST related cluster

447

8e-44

50% (89/175)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005515|protein binding|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0007165|signal transduction|IEA; GO:0016301|kinase activity|IEA

ACL00009256

Probable protein phosphatase PP2A regulatory subunit related cluster

212

7e-17

52% (48/92)

GO:0004721|phosphoprotein phosphatase activity|IEA; GO:0005488|binding|IEA

ACL00009257

unclassified

ACL00009258

unclassified

ACL00009259

multi-domain protein

113

4e-06

22% (55/240)

ACL00009260

CG2140

Cytochrome b5 related cluster

183

5e-13

45% (36/79)

GO:0005792|microsome|IEA; GO:0006118|electron transport|IEA; GO:0016021|integral to membrane|IEA

ACL00009261

gclc

Similar to glutamate-cysteine ligase, catalytic subunit related cluster

448

8e-44

46% (88/189)

GO:0004357|glutamate-cysteine ligase activity|IEA; GO:0006750|glutathione biosynthesis|IEA; GO:0016874|ligase activity|IEA

ACL00009262

G protein alpha subunit related cluster

306

2e-27

35% (64/179)

GO:0004871|signal transducer activity|IEA; GO:0005525|GTP binding|IEA; GO:0007186|G-protein coupled receptor protein signaling pathway|IEA

ACL00009263

unclassified

ACL00009264

mRNA cap methyltransferase related cluster

440

6e-43

48% (101/207)

GO:0006370|mRNA capping|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA

ACL00009265

Putative cullin related cluster

411

7e-40

54% (79/146)

Posttranslational modification, protein turnover, chaperones

GO:0007049|cell cycle|IEA

ACL00009266

Protein serine/threonine kinase related cluster

92

5e-25

47% (17/36)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0004713|protein-tyrosine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00009267

unclassified

ACL00009268

unclassified

ACL00009269

Tymo_45kd_70kd domain containing protein

109

9e-06

24% (46/188)

ACL00009270

Putative splicing factor related cluster

136

5e-08

34% (32/94)

GO:0003676|nucleic acid binding|IEA; GO:0005634|nucleus|IEA; GO:0008270|zinc ion binding|IEA

ACL00009271

NOPD1

Proliferating-cell nucleolar antigen P120, putative related cluster

329

5e-30

38% (78/205)

GO:0003723|RNA binding|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA

ACL00009272

Putative helicase C6F12.16c related cluster

461

2e-45

57% (90/157)

Replication, recombination and repair

GO:0003676|nucleic acid binding|IEA; GO:0004386|helicase activity|IEA; GO:0005524|ATP binding|IEA; GO:0005634|nucleus|IEA; GO:0008026|ATP-dependent helicase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00009273

G6PI

Glucose-6-phosphate isomerase related cluster

678

2e-70

71% (132/185)

5.3.1.9

Carbohydrate transport and metabolism

Glycolysis / Gluconeogenesis Pentose phosphate pathway Starch and sucrose metabolism

GO:0004347|glucose-6-phosphate isomerase activity|IEA; GO:0006094|gluconeogenesis|IEA; GO:0006096|glycolysis|IEA; GO:0016853|isomerase activity|IEA

ACL00009274

Unassigned protein

120

3e-06

27% (29/105)

ACL00009275

unclassified

ACL00009276

unclassified

ACL00009277

VATF

Vacuolar ATP synthase subunit F related cluster

131

2e-07

64% (25/39)

3.6.3.14

Energy production and conversion

ATP synthesis Oxidative phosphorylation

GO:0005624|membrane fraction|TAS; GO:0006754|ATP biosynthesis|IEA; GO:0015078|hydrogen ion transporter activity|IEA; GO:0015078|hydrogen ion transporter activity|TAS; GO:0015986|ATP synthesis coupled proton transport|IEA; GO:0015992|proton transport|IEA; GO:0015992|proton transport|TAS; GO:0016469|proton-transporting two-sector ATPase complex|IEA; GO:0016469|proton-transporting two-sector ATPase complex|TAS; GO:0016787|hydrolase activity|IEA; GO:0046933|hydrogen-transporting ATP synthase activity, rotational mechanism|IEA; GO:0046961|hydrogen-transporting ATPase activity, rotational mechanism|IEA

ACL00009278

unclassified

ACL00009279

putative purine nucleotide binding protein [Oryza sativa (japonica cultivar-group)] dbj|BAD33311.1| putative purine nucleotide binding protein [Oryza sativa (japonica cultivar-group)]

424

1e-40

44% (88/200)

ACL00009280

unclassified

ACL00009281

3-hydroxyisobutyrate dehydrogenase related cluster

232

4e-19

58% (47/80)

Lipid transport and metabolism

GO:0004616|phosphogluconate dehydrogenase (decarboxylating) activity|IEA; GO:0006098|pentose-phosphate shunt|IEA; GO:0006573|valine metabolism|IEA; GO:0008442|3-hydroxyisobutyrate dehydrogenase activity|IEA

ACL00009282

Predicted nucletide kinase related cluster

169

2e-11

39% (38/97)

Nucleotide transport and metabolism

GO:0000103|sulfate assimilation|IEA; GO:0003723|RNA binding|IEA; GO:0005524|ATP binding|IEA; GO:0005525|GTP binding|IEA; GO:0005786|signal recognition particle (sensu Eukaryota)|IEA; GO:0006614|SRP-dependent cotranslational protein-membrane targeting|IEA; GO:0016301|kinase activity|IEA; GO:0016772|transferase activity, transferring phosphorus-containing groups|IEA

ACL00009283

unclassified

ACL00009284

unclassified

ACL00009285

MutT/nudix family protein related cluster

131

2e-07

37% (43/116)

GO:0016787|hydrolase activity|IEA

ACL00009286

CGI-51

SAM50-like protein CGI-51 related cluster

125

9e-07

28% (37/130)

GO:0000004|biological_process unknown|ND; GO:0005554|molecular_function unknown|ND; GO:0005739|mitochondrion|IEA; GO:0008372|cellular_component unknown|ND; GO:0016021|integral to membrane|IEA; GO:0019867|outer membrane|IEA

ACL00009287

unclassified

ACL00009288

unclassified

ACL00009289

Tetrahydrofolylpolyglutamate synthase-like protein related cluster

139

2e-08

36% (38/104)

GO:0004326|tetrahydrofolylpolyglutamate synthase activity|IEA; GO:0005524|ATP binding|IEA; GO:0009396|folic acid and derivative biosynthesis|IEA

ACL00009290

unclassified

ACL00009291

Fimbrin related cluster

186

8e-14

42% (34/80)

Cytoskeleton

GO:0003779|actin binding|IEA; GO:0005509|calcium ion binding|IEA

ACL00009292

Unassigned protein

122

2e-06

42% (25/59)

ACL00009293

Ubiquitin carrier protein 4 related cluster

225

2e-18

77% (41/53)

6.3.2.19

Posttranslational modification, protein turnover, chaperones

GO:0004840|ubiquitin conjugating enzyme activity|IEA; GO:0006464|protein modification|IEA; GO:0006512|ubiquitin cycle|IEA; GO:0016874|ligase activity|IEA

ACL00009294

unclassified

ACL00009295

grxC

Glutaredoxin related cluster

123

2e-06

42% (27/64)

Posttranslational modification, protein turnover, chaperones

GO:0005489|electron transporter activity|IEA; GO:0006118|electron transport|IEA

ACL00009296

unclassified

ACL00009297

Probable secreted protein related cluster

180

5e-13

46% (40/86)

ACL00009298

Similar to v-Ha-ras Harvey rat sarcoma viral oncogene homolog related cluster

195

2e-14

78% (36/46)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00009299

unclassified

ACL00009300

Unassigned protein

ACL00009301

Sucrose cleavage protein-like related cluster

119

4e-06

34% (34/99)

ACL00009302

ubiquitin-conjugating BIR-domain enzyme APOLLON

58

2e-22

55% (11/20)

Posttranslational modification, protein turnover, chaperones

ACL00009303

unclassified

ACL00009304

VPS35

Vacuolar protein sorting 35 related cluster

48

3e-15

33% (6/18)

GO:0005515|protein binding|IPI; GO:0005829|cytosol|IDA; GO:0006810|transport|IEA; GO:0015031|protein transport|IEA; GO:0042147|retrograde transport, endosome to Golgi|NAS

ACL00009305

U2 snRNP auxiliary factor, small subunit related cluster

160

6e-31

56% (27/48)

GO:0003676|nucleic acid binding|IEA; GO:0003723|RNA binding|IEA; GO:0005634|nucleus|IEA

ACL00009306

unclassified

ACL00009307

unclassified

ACL00009308

PSN domain containing protein

84

1e-04

14% (7/50)

ACL00009309

Unassigned protein

ACL00009310

unclassified

ACL00009311

TBC domain containing protein

109

3e-06

23% (15/63)

ACL00009312

unclassified

ACL00009313

unclassified

ACL00009314

Sybl1

Similar to Arabidopsis thaliana (Mouse-ear cress). synaptobrevin-like protein related cluster

123

2e-06

29% (26/88)

ACL00009315

unclassified

ACL00009316

CG6625

Alpha-soluble NSF attachment protein related cluster

252

2e-21

37% (46/122)

GO:0005478|intracellular transporter activity|IEA; GO:0005488|binding|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0005794|Golgi apparatus|IEA; GO:0006810|transport|IEA; GO:0006886|intracellular protein transport|IEA; GO:0015031|protein transport|IEA

ACL00009317

unclassified

ACL00009318

Nucleotide exchange factor RasGEF K related cluster

240

4e-20

45% (53/116)

GO:0005085|guanyl-nucleotide exchange factor activity|IEA; GO:0007242|intracellular signaling cascade|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00009319

unclassified

ACL00009320

SNF7 domain containing protein

187

3e-15

36% (27/75)

ACL00009321

Calpain_III domain containing protein

118

6e-07

38% (19/50)

ACL00009322

unclassified

ACL00009323

unclassified

ACL00009324

unclassified

ACL00009325

unclassified

ACL00009326

unclassified

ACL00009327

unclassified

ACL00009328

unclassified

ACL00009329

multi-domain protein

134

9e-09

49% (29/59)

ACL00009330

unclassified

ACL00009331

Related to GTPase activating protein related cluster

149

3e-40

43% (25/57)

General function prediction only

ACL00009332

Mrpl49

Mitochondrial 60s ribosomal protein L49 related cluster

122

2e-06

34% (30/88)

GO:0003735|structural constituent of ribosome|IEA; GO:0003743|translation initiation factor activity|IEA; GO:0005554|molecular_function unknown|ND; GO:0005622|intracellular|IEA; GO:0005739|mitochondrion|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006413|translational initiation|IEA; GO:0008151||NAS; GO:0008372|cellular_component unknown|ND

ACL00009333

unclassified

ACL00009334

unclassified

ACL00009335

DM6 domain containing protein

99

4e-06

23% (25/108)

ACL00009336

unclassified

ACL00009337

NUP43

Nucleoporin Nup43 related cluster

154

8e-10

28% (52/185)

GO:0005634|nucleus|IEA; GO:0006810|transport|IEA; GO:0015031|protein transport|IEA

ACL00009338

Putative trehalose-6-phosphate synthase related cluster

144

1e-08

29% (46/157)

GO:0003824|catalytic activity|IEA; GO:0003825|alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity|IEA; GO:0004805|trehalose-phosphatase activity|IEA; GO:0005992|trehalose biosynthesis|IEA; GO:0008152|metabolism|IEA

ACL00009339

RPOLD domain containing protein

90

2e-05

29% (9/31)

ACL00009340

Silverleaf whitefly-induced protein 1 related cluster

547

3e-55

51% (106/205)

GO:0006508|proteolysis and peptidolysis|IEA; GO:0008237|metallopeptidase activity|IEA

ACL00009341

unclassified

ACL00009342

unclassified

ACL00009343

unclassified

ACL00009344

Unassigned protein

ACL00009345

Vac14

Vac14; hydin

152

1e-09

34% (43/123)

ACL00009346

unclassified

ACL00009347

Cyclooxygenase related cluster

132

1e-07

32% (31/94)

GO:0004601|peroxidase activity|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00009348

unclassified

ACL00009349

Putative iron-sulfur binding oxidoreductase related cluster

242

4e-20

34% (60/174)

GO:0006118|electron transport|IEA; GO:0008121|ubiquinol-cytochrome-c reductase activity|IEA; GO:0016020|membrane|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0045285|ubiquinol-cytochrome-c reductase complex|IEA

ACL00009350

unclassified

ACL00009351

ASAH2

Alkaline ceramidase related cluster

186

8e-14

42% (38/89)

ACL00009352

Putative thiamine pyrophosphokinase related cluster

186

8e-14

55% (43/78)

Coenzyme transport and metabolism

GO:0004788|thiamin diphosphokinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006772|thiamin metabolism|IEA; GO:0009229|thiamin diphosphate biosynthesis|IEA; GO:0016301|kinase activity|IEA

ACL00009353

unclassified

ACL00009354

unclassified

ACL00009355

Leng8

Leng8; leukocyte receptor cluster (LRC) member 8

78

4e-16

68% (15/22)

ACL00009356

DGA1

Diacylglycerol O-acyltransferase 1 related cluster

127

1e-24

55% (22/40)

2.3.1.20

GO:0004144|diacylglycerol O-acyltransferase activity|IDA; GO:0004144|diacylglycerol O-acyltransferase activity|IEA; GO:0008415|acyltransferase activity|IEA; GO:0016021|integral to membrane|IEA; GO:0016740|transferase activity|IEA; GO:0019432|triacylglycerol biosynthesis|IDA; GO:0019915|lipid storage|IC; GO:0046339|diacylglycerol metabolism|IC

ACL00009357

Tymo_45kd_70kd domain containing protein

120

4e-07

31% (35/112)

ACL00009358

unclassified

ACL00009359

unclassified

ACL00009360

Unassigned protein

ACL00009361

unclassified

ACL00009362

Unknown EST

110

3e-06

48% (19/39)

ACL00009363

Unassigned protein

ACL00009364

unclassified

ACL00009365

unclassified

ACL00009366

SEL1 domain containing protein

111

7e-08

33% (12/36)

ACL00009367

pah

Phenylalanine hydroxylase related cluster

198

3e-15

71% (33/46)

Amino acid transport and metabolism

GO:0004497|monooxygenase activity|IEA; GO:0004505|phenylalanine 4-monooxygenase activity|IEA; GO:0005506|iron ion binding|IEA; GO:0006559|L-phenylalanine catabolism|IEA; GO:0008152|metabolism|IEA; GO:0009072|aromatic amino acid family metabolism|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016597|amino acid binding|IEA

ACL00009368

unclassified

ACL00009369

unclassified

ACL00009370

Unassigned protein

138

7e-08

32% (41/127)

ACL00009371

DM6 domain containing protein

86

1e-04

27% (23/83)

ACL00009372

unclassified

ACL00009373

unclassified

ACL00009374

unclassified

ACL00009375

Unassigned protein

ACL00009376

Putative phosphatidylcholine acyltransferase related cluster

137

4e-08

49% (25/51)

GO:0004607|phosphatidylcholine-sterol O-acyltransferase activity|IEA; GO:0006629|lipid metabolism|IEA; GO:0008415|acyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00009377

SMC_N domain containing protein

200

1e-16

44% (31/69)

ACL00009378

Cell cycle control protein cwf16 related cluster

230

6e-19

41% (49/119)

GO:0000398|nuclear mRNA splicing, via spliceosome|IEA; GO:0005634|nucleus|IEA; GO:0006397|mRNA processing|IEA

ACL00009379

multi-domain protein

132

1e-08

22% (28/127)

ACL00009380

Map3k11

Similar to mitogen-activated protein kinase kinase kinase 9 related cluster

204

6e-16

45% (42/93)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0004713|protein-tyrosine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00009381

multi-domain protein

108

6e-06

30% (29/96)

ACL00009382

unclassified

ACL00009383

FYVE domain containing protein

205

5e-17

50% (25/50)

ACL00009384

unclassified

ACL00009385

Mbtps1

Membrane-bound transcription factor site-1 protease precursor related cluster

426

2e-41

48% (79/162)

3.4.21.-

GO:0004252|serine-type endopeptidase activity|IEA; GO:0004252|serine-type endopeptidase activity|TAS; GO:0004289|subtilase activity|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0005788|endoplasmic reticulum lumen|TAS; GO:0005794|Golgi apparatus|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0006508|proteolysis and peptidolysis|TAS; GO:0006629|lipid metabolism|IEA; GO:0008203|cholesterol metabolism|IEA; GO:0008233|peptidase activity|IEA; GO:0016021|integral to membrane|IEA; GO:0016787|hydrolase activity|IEA

ACL00009386

Ank3

190 kDa ankyrin isoform related cluster

135

1e-07

34% (30/86)

General function prediction only

GO:0005515|protein binding|IEA; GO:0005515|protein binding|NAS; GO:0007165|signal transduction|IEA; GO:0019899|enzyme binding|NAS; GO:0043065|positive regulation of apoptosis|NAS

ACL00009387

unclassified

ACL00009388

multi-domain protein

109

8e-06

36% (35/95)

ACL00009389

Tymo_45kd_70kd domain containing protein

105

6e-06

28% (18/64)

ACL00009390

unclassified

ACL00009391

unclassified

ACL00009392

unclassified

ACL00009393

RIM2

Mitochondrial carrier protein RIM2 related cluster

290

1e-25

37% (57/152)

GO:0000002|mitochondrial genome maintenance|IGI; GO:0005488|binding|IEA; GO:0005739|mitochondrion|IDA; GO:0005739|mitochondrion|IEA; GO:0005743|mitochondrial inner membrane|IEA; GO:0006810|transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0019866|inner membrane|IEA

ACL00009394

ABCD3

ATP-binding cassette, sub-family D, member 3 related cluster

374

2e-35

53% (74/138)

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0005777|peroxisome|IEA; GO:0005778|peroxisomal membrane|TAS; GO:0005779|integral to peroxisomal membrane|TAS; GO:0006810|transport|IEA; GO:0007031|peroxisome organization and biogenesis|TAS; GO:0015910|peroxisomal long-chain fatty acid import|TAS; GO:0016021|integral to membrane|IEA; GO:0016887|ATPase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA; GO:0042626|ATPase activity, coupled to transmembrane movement of substances|IEA; GO:0042626|ATPase activity, coupled to transmembrane movement of substances|TAS

ACL00009395

AMME syndrome candidate gene 1 protein related cluster

160

8e-11

33% (44/133)

GO:0000004|biological_process unknown|ND; GO:0005554|molecular_function unknown|ND; GO:0008372|cellular_component unknown|ND

ACL00009396

CSTF1

Cleavage stimulation factor, 50 kDa subunit related cluster

448

5e-44

50% (86/170)

GO:0003723|RNA binding|TAS; GO:0005634|nucleus|IEA; GO:0005634|nucleus|TAS; GO:0006378|mRNA polyadenylylation|TAS; GO:0006379|mRNA cleavage|TAS; GO:0006396|RNA processing|TAS

ACL00009397

Similar to phospholipase B related cluster

141

3e-08

29% (29/99)

GO:0003824|catalytic activity|IEA

ACL00009398

unclassified

ACL00009399

unclassified

ACL00009400

PEPD

Xaa-Pro dipeptidase related cluster

506

2e-50

49% (98/199)

3.4.13.9

Amino acid transport and metabolism

GO:0004251|X-Pro dipeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008233|peptidase activity|IEA; GO:0008235|metalloexopeptidase activity|IEA; GO:0008237|metallopeptidase activity|IEA; GO:0016787|hydrolase activity|IEA; GO:0016805|dipeptidase activity|IEA; GO:0030145|manganese ion binding|IEA; GO:0030574|collagen catabolism|IEA

ACL00009401

SLA/LP autoantigen homolog related cluster

583

2e-59

62% (114/182)

Amino acid transport and metabolism

ACL00009402

Predicted membrane protein related cluster

126

8e-07

33% (30/90)

ACL00009403

unclassified

ACL00009404

unclassified

ACL00009405

unclassified

ACL00009406

TT_ORF1 domain containing protein

122

2e-07

50% (29/58)

ACL00009407

unclassified

ACL00009408

Putative carnitine/acylcarnitine translocase related cluster

279

1e-24

45% (55/122)

GO:0005215|transporter activity|IEA; GO:0005488|binding|IEA; GO:0005743|mitochondrial inner membrane|IEA; GO:0006810|transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA

ACL00009409

DM6 domain containing protein

85

7e-05

28% (21/74)

ACL00009410

unclassified

ACL00009411

unclassified

ACL00009412

unclassified

ACL00009413

Unknown EST

46

3e-08

90% (9/10)

ACL00009414

OPLAH

Related to 5-oxoprolinase related cluster

143

2e-39

70% (28/40)

Glutathione metabolism

GO:0003824|catalytic activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00009415

unclassified

ACL00009416

UPP_synthetase domain containing protein

123

2e-07

27% (29/104)

ACL00009417

unclassified

ACL00009418

unclassified

ACL00009419

ANIA

Major outer membrane protein Pan 1 precursor related cluster

577

1e-58

51% (113/219)

1.7.2.1

GO:0005507|copper ion binding|IEA; GO:0006807|nitrogen compound metabolism|IEA; GO:0019867|outer membrane|IEA

ACL00009420

Glutaminyl cyclase related cluster

242

2e-20

45% (53/117)

GO:0006508|proteolysis and peptidolysis|IEA; GO:0008233|peptidase activity|IEA

ACL00009421

unclassified

ACL00009422

unclassified

ACL00009425

LSU rRNA; Parnassia fimbriata large subunit 26S ribosomal RNA gene, partial sequence.

64

6e-30

95% (80/84)

ACL00009426

LSU rRNA; Buccegia romanica 25S rRNA gene for 25S ribosomal RNA.

93

2e-47

92% (125/135)

ACL00009427

Unknown EST

95

6e-06

46% (18/39)

ACL00009428

rpl37-1

60S ribosomal protein L33-A related cluster

117

7e-22

57% (22/38)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00009429

Similar to Chlorobium tepidum. phosphoenolpyruvate carboxykinase related cluster

173

6e-12

36% (33/90)

Energy production and conversion

GO:0004611|phosphoenolpyruvate carboxykinase activity|IEA; GO:0005525|GTP binding|IEA; GO:0006094|gluconeogenesis|IEA; GO:0016301|kinase activity|IEA

ACL00009430

unclassified

ACL00009431

LKHA

Leukotriene A-4 hydrolase related cluster

382

4e-36

38% (82/212)

3.3.2.6

GO:0003824|catalytic activity|IEA; GO:0004179|membrane alanyl aminopeptidase activity|IEA; GO:0004463|leukotriene-A4 hydrolase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008237|metallopeptidase activity|IEA; GO:0016787|hydrolase activity|IEA; GO:0019370|leukotriene biosynthesis|IEA

ACL00009432

Histone H2B related cluster

193

1e-14

88% (38/43)

GO:0000786|nucleosome|IEA; GO:0003677|DNA binding|IEA; GO:0005634|nucleus|IEA; GO:0005694|chromosome|IEA; GO:0006334|nucleosome assembly|IEA; GO:0007001|chromosome organization and biogenesis (sensu Eukaryota)|IEA

ACL00009433

60S ribosomal protein L39 related cluster

247

6e-21

86% (44/51)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00009435

unclassified

ACL00009436

Unknown EST

132

4e-18

92% (24/26)

ACL00009437

LSU rRNA; Parnassia fimbriata large subunit 26S ribosomal RNA gene, partial sequence.

94

1e-47

90% (149/164)

ACL00009438

LimD related cluster

249

9e-21

41% (59/141)

GO:0008270|zinc ion binding|IEA

ACL00009439

LSU rRNA; T.gondii (strain P) rDNA for 17s,5.8s,26s,and 5s ribosomal RNA.

34

1e-11

92% (46/50)

ACL00009440

Actin-binding protein fragmin P related cluster

338

4e-31

49% (77/157)

GO:0003779|actin binding|IEA

ACL00009441

Cytochrome c related cluster

363

4e-34

60% (63/104)

Energy production and conversion

GO:0005489|electron transporter activity|IEA; GO:0005739|mitochondrion|IEA; GO:0005746|mitochondrial electron transport chain|IEA; GO:0006118|electron transport|IEA

ACL00009442

LSU rRNA; Sarcocystis tenella large subunit ribosomal RNA gene, complete sequence.

154

2e-83

94% (184/194)

ACL00009443

CYPH

Peptidyl-prolyl cis-trans isomerase related cluster

339

2e-31

76% (62/81)

5.2.1.8

Posttranslational modification, protein turnover, chaperones

GO:0003755|peptidyl-prolyl cis-trans isomerase activity|IEA; GO:0006457|protein folding|IEA; GO:0016853|isomerase activity|IEA

ACL00009444

DUF482 domain containing protein

300

6e-28

44% (47/106)

ACL00009445

Autophagy protein 8 related cluster

160

5e-10

50% (30/59)

GO:0005875|microtubule associated complex|IPI; GO:0006512|ubiquitin cycle|IEA; GO:0006623|protein-vacuolar targeting|IMP; GO:0006914|autophagy|IEA; GO:0006914|autophagy|IGI; GO:0008017|microtubule binding|IPI; GO:0016020|membrane|IEA

ACL00009446

IPYR

Inorganic pyrophosphatase related cluster

58

2e-63

70% (12/17)

3.6.1.1

Energy production and conversion

GO:0000287|magnesium ion binding|IEA; GO:0004427|inorganic diphosphatase activity|IEA; GO:0005737|cytoplasm|IEA; GO:0008152|metabolism|IEA; GO:0016462|pyrophosphatase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00009447

LSU rRNA; T.gondii (strain P) rDNA for 17s,5.8s,26s,and 5s ribosomal RNA.

83

6e-41

91% (112/122)

ACL00009448

60S ribosomal protein L33-A related cluster

334

1e-30

58% (63/108)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00009449

Ribosomal_L41 domain containing protein

128

3e-08

92% (23/25)

ACL00009450

Ribosomal_L41 domain containing protein

128

4e-08

92% (23/25)

ACL00009451

LSU rRNA; Parnassia fimbriata large subunit 26S ribosomal RNA gene, partial sequence.

106

1e-54

92% (151/164)

ACL00009452

Rps17

Ribosomal protein S17 related cluster

484

6e-48

70% (89/126)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00009453

60S ribosomal protein L10a related cluster

649

7e-67

56% (125/220)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00009454

Ubiquitin related cluster

516

1e-51

68% (103/150)

Posttranslational modification, protein turnover, chaperones

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00009455

40S ribosomal protein S2 homolog related cluster

800

4e-84

69% (151/217)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0015935|small ribosomal subunit|IEA; GO:0030529|ribonucleoprotein complex|IEA