Automatic annotation results for AC.fasta

Ssequence id

Locus

Description

Alignment Score

E-value

% Sequence Identity

EC number

COG Function

KEGG Pathways

GeneOntology

ACL00000001

Ribosomal_S30 domain containing protein

245

9e-22

70% (42/60)

ACL00000002

VATF

Probable vacuolar ATP synthase subunit F related cluster

164

3e-11

53% (30/56)

3.6.3.14

Energy production and conversion

GO:0006754|ATP biosynthesis|IEA; GO:0015078|hydrogen ion transporter activity|IEA; GO:0015986|ATP synthesis coupled proton transport|IEA; GO:0015992|proton transport|IEA; GO:0016469|proton-transporting two-sector ATPase complex|IEA; GO:0016787|hydrolase activity|IEA; GO:0046933|hydrogen-transporting ATP synthase activity, rotational mechanism|IEA; GO:0046961|hydrogen-transporting ATPase activity, rotational mechanism|IEA

ACL00000008

Ras-related protein Rap-1 related cluster

525

1e-52

68% (103/151)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00000011

CBS domain protein related cluster

175

9e-12

28% (51/178)

General function prediction only

ACL00000012

Rpl31

60S ribosomal protein L31 related cluster

422

7e-41

68% (80/117)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000016

multi-domain protein

132

1e-08

22% (26/114)

ACL00000018

Ubiquitin related cluster

390

5e-37

96% (78/81)

Posttranslational modification, protein turnover, chaperones

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000019

Peroxidase ppod11 related cluster

132

2e-07

31% (42/134)

GO:0004601|peroxidase activity|IEA

ACL00000022

Heat shock cognate protein related cluster

2464

0.0

76% (465/609)

GO:0005524|ATP binding|IEA; GO:0006457|protein folding|IEA; GO:0051082|unfolded protein binding|IEA

ACL00000025

PPB

Alkaline phosphatase related cluster

360

2e-33

51% (80/155)

3.1.3.1

Inorganic ion transport and metabolism

GO:0000287|magnesium ion binding|IEA; GO:0004035|alkaline phosphatase activity|IEA; GO:0008152|metabolism|IEA; GO:0016021|integral to membrane|IEA; GO:0016787|hydrolase activity|IEA

ACL00000026

AhpC/TSA family protein related cluster

375

2e-35

47% (73/153)

ACL00000027

multi-domain protein

139

6e-09

22% (55/242)

ACL00000030

F27G19.90; 3' exoribonuclease family domain 1-containing protein

343

1e-31

37% (78/206)

ACL00000032

multi-domain protein

125

2e-07

15% (35/223)

ACL00000033

unclassified

ACL00000034

putative reductase [Streptomyces avermitilis MA-4680] dbj|BAC68620.1| putative reductase [Streptomyces avermitilis MA-4680]

205

4e-15

32% (55/168)

ACL00000035

CAH

Carbonic anhydrase precursor related cluster

271

3e-23

38% (58/150)

4.2.1.1

Inorganic ion transport and metabolism

Nitrogen metabolism

GO:0004089|carbonate dehydratase activity|IEA; GO:0006730|one-carbon compound metabolism|IEA; GO:0008270|zinc ion binding|IEA; GO:0016829|lyase activity|IEA; GO:0042597|periplasmic space|IEA

ACL00000036

[HC] COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

404

2e-39

44% (73/163)

ACL00000037

Transcriptional regulator related cluster

154

7e-10

30% (42/137)

GO:0003677|DNA binding|IEA; GO:0003700|transcription factor activity|IEA; GO:0005622|intracellular|IEA; GO:0006350|transcription|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA

ACL00000038

unclassified

ACL00000039

Unassigned protein

155

3e-10

44% (32/72)

ACL00000040

unclassified

ACL00000041

unclassified

ACL00000042

UGDH

UDP-glucose dehydrogenase related cluster

317

2e-60

60% (57/95)

1.1.1.22

Cell wall/membrane/envelope biogenesis

Nucleotide sugars metabolism Pentose and glucuronate interconversions Starch and sucrose metabolism

GO:0006118|electron transport|IEA

ACL00000043

Cytochrome B5 related cluster

253

3e-21

36% (51/138)

ACL00000044

unclassified

ACL00000045

TPP1

Tripeptidyl-peptidase I precursor related cluster

154

1e-31

60% (33/55)

3.4.14.9

GO:0004252|serine-type endopeptidase activity|IEA; GO:0005764|lysosome|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA; GO:0019131|tripeptidyl-peptidase I activity|IEA

ACL00000046

unclassified

ACL00000048

Histone H4 related cluster

422

6e-41

96% (82/85)

Chromatin structure and dynamics

GO:0000786|nucleosome|IEA; GO:0003677|DNA binding|IEA; GO:0005634|nucleus|IEA; GO:0005694|chromosome|IEA; GO:0006334|nucleosome assembly|IEA; GO:0007001|chromosome organization and biogenesis (sensu Eukaryota)|IEA

ACL00000049

[T] COG0589 Universal stress protein UspA and related nucleotide-binding proteins

118

6e-06

28% (42/150)

Signal transduction mechanisms

ACL00000051

unclassified

ACL00000052

unclassified

ACL00000053

Eif3s6ip

Eukaryotic translation initiation factor 3 subunit 6 interacting protein related cluster

392

2e-37

46% (77/167)

GO:0006412|protein biosynthesis|IEA

ACL00000054

GTP-binding protein yptV4 related cluster

753

4e-79

74% (144/193)

General function prediction only

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00000055

unclassified

ACL00000056

3-alpha-hydroxysteroid dehydrogenase-like protein related cluster

193

1e-14

40% (49/120)

GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000057

COX12

Cytochrome c oxidase polypeptide VIb related cluster

195

1e-14

51% (32/62)

1.9.3.1

Oxidative phosphorylation

GO:0004129|cytochrome-c oxidase activity|IEA; GO:0005739|mitochondrion|IEA; GO:0006118|electron transport|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000058

DUF985 domain containing protein

471

1e-47

51% (70/137)

ACL00000059

RPL35

Ribosomal protein L35 related cluster

407

3e-39

68% (84/122)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000060

FBOX domain containing protein

97

1e-05

31% (13/41)

ACL00000061

PSMB6

Proteasome subunit related cluster

55

8e-64

46% (12/26)

3.4.25.1

Posttranslational modification, protein turnover, chaperones

Proteasome

GO:0004175|endopeptidase activity|IEA; GO:0005829|cytosol|IEA; GO:0005839|proteasome core complex (sensu Eukaryota)|IEA; GO:0006511|ubiquitin-dependent protein catabolism|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00000063

multi-domain protein

134

2e-08

21% (48/222)

ACL00000064

EIF4A2

Eukaryotic initiation factor 4A-II related cluster

593

2e-60

68% (109/159)

GO:0003676|nucleic acid binding|IEA; GO:0003677|DNA binding|IEA; GO:0003723|RNA binding|IEA; GO:0003743|translation initiation factor activity|IEA; GO:0003743|translation initiation factor activity|TAS; GO:0004386|helicase activity|IEA; GO:0004386|helicase activity|TAS; GO:0005524|ATP binding|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006446|regulation of translational initiation|TAS; GO:0008026|ATP-dependent helicase activity|IEA; GO:0016281|eukaryotic translation initiation factor 4F complex|TAS

ACL00000065

unclassified

ACL00000067

multi-domain protein

125

1e-07

30% (37/121)

ACL00000069

Rho GDP-dissociation inhibitor related cluster

503

5e-50

50% (100/200)

GO:0005094|Rho GDP-dissociation inhibitor activity|IEA; GO:0005737|cytoplasm|IEA

ACL00000070

Histone protein Hist2h3c1 related cluster

441

6e-43

68% (94/138)

Chromatin structure and dynamics

GO:0000786|nucleosome|IEA; GO:0003677|DNA binding|IEA; GO:0005634|nucleus|IEA; GO:0005694|chromosome|IEA; GO:0006334|nucleosome assembly|IEA; GO:0007001|chromosome organization and biogenesis (sensu Eukaryota)|IEA

ACL00000072

Sulfide-quinone reductase related cluster

368

1e-34

51% (61/119)

GO:0006118|electron transport|IEA; GO:0015036|disulfide oxidoreductase activity|IEA

ACL00000073

SQRDL

Sulfide:quinone oxidoreductase, mitochondrial precursor related cluster

553

1e-55

49% (102/206)

1.-.-.-

GO:0005739|mitochondrion|IEA; GO:0006118|electron transport|IEA; GO:0015036|disulfide oxidoreductase activity|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000077

probable transmembrane protein

377

5e-36

57% (71/123)

ACL00000078

Putative transport protein related cluster

223

1e-17

33% (48/142)

ACL00000079

ATP synthase subunit, probable related cluster

150

1e-09

48% (25/52)

Energy production and conversion

GO:0015986|ATP synthesis coupled proton transport|IEA; GO:0016469|proton-transporting two-sector ATPase complex|IEA; GO:0016787|hydrolase activity|IEA; GO:0046933|hydrogen-transporting ATP synthase activity, rotational mechanism|IEA; GO:0046961|hydrogen-transporting ATPase activity, rotational mechanism|IEA

ACL00000080

Putative amino acid efflux transmembrane protein related cluster

207

8e-38

66% (38/57)

Amino acid transport and metabolism

GO:0005293|lysine permease activity|IEA; GO:0006865|amino acid transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA

ACL00000084

RNZ2

Zinc phosphodiesterase ELAC protein 2 related cluster

191

5e-14

37% (37/100)

3.1.26.11

GO:0004518|nuclease activity|IEA; GO:0004519|endonuclease activity|IEA; GO:0005634|nucleus|IEA; GO:0008033|tRNA processing|IEA; GO:0008151||IEA; GO:0016787|hydrolase activity|IEA

ACL00000085

unclassified

ACL00000086

GGLO

L-gulonolactone oxidase related cluster

386

8e-37

44% (74/168)

1.1.3.8

Ascorbate and aldarate metabolism

GO:0003885|D-arabinono-1,4-lactone oxidase activity|IEA; GO:0005792|microsome|IEA; GO:0006118|electron transport|IEA; GO:0009058|biosynthesis|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016899|oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor|IEA; GO:0019853|L-ascorbic acid biosynthesis|IEA; GO:0050105|L-gulonolactone oxidase activity|IEA

ACL00000087

ABC transporter AbcH.2 related cluster

721

2e-75

57% (139/243)

Defense mechanisms

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0016887|ATPase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

ACL00000088

TXNRD3

Thioredoxin reductase TR1 related cluster

205

1e-15

66% (40/60)

GO:0005737|cytoplasm|IEA; GO:0006118|electron transport|IEA; GO:0015036|disulfide oxidoreductase activity|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016654|oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor|IEA; GO:0050660|FAD binding|IEA

ACL00000089

rpmH

Ribosomal protein L34 related cluster

142

1e-08

56% (25/44)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00000090

unclassified

ACL00000091

unclassified

ACL00000092

unclassified

ACL00000093

unclassified

ACL00000094

SUCA

Succinyl-CoA ligase [GDP-forming] alpha-chain, mitochondrial precursor related cluster

995

1e-107

68% (201/293)

6.2.1.4

Energy production and conversion

GO:0003824|catalytic activity|IEA; GO:0004776|succinate-CoA ligase (GDP-forming) activity|IEA; GO:0005525|GTP binding|IEA; GO:0005739|mitochondrion|IEA; GO:0006099|tricarboxylic acid cycle|IEA; GO:0008152|metabolism|IEA; GO:0016874|ligase activity|IEA

ACL00000095

unclassified

ACL00000097

unclassified

ACL00000099

ARL10B

ADP-ribosylation factor-like protein related cluster

535

7e-54

64% (99/154)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00000101

ATPB

ATP synthase beta chain related cluster

198

8e-15

74% (37/50)

3.6.3.14

Energy production and conversion

ATP synthesis Oxidative phosphorylation

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0006754|ATP biosynthesis|IEA; GO:0008553|hydrogen-exporting ATPase activity, phosphorylative mechanism|IEA; GO:0015078|hydrogen ion transporter activity|IEA; GO:0015986|ATP synthesis coupled proton transport|IEA; GO:0015992|proton transport|IEA; GO:0016021|integral to membrane|IEA; GO:0016469|proton-transporting two-sector ATPase complex|IEA; GO:0016787|hydrolase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA; GO:0045255|hydrogen-translocating F-type ATPase complex|IEA; GO:0046933|hydrogen-transporting ATP synthase activity, rotational mechanism|IEA; GO:0046961|hydrogen-transporting ATPase activity, rotational mechanism|IEA

ACL00000102

rps28-2

40S ribosomal protein S28 related cluster

148

3e-09

72% (31/43)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000103

Histone H4 related cluster

404

6e-39

96% (79/82)

Chromatin structure and dynamics

GO:0000786|nucleosome|IEA; GO:0003677|DNA binding|IEA; GO:0005634|nucleus|IEA; GO:0005694|chromosome|IEA; GO:0006334|nucleosome assembly|IEA; GO:0007001|chromosome organization and biogenesis (sensu Eukaryota)|IEA

ACL00000104

Peptidyl-prolyl cis-trans isomerase related cluster

598

6e-61

56% (124/220)

Posttranslational modification, protein turnover, chaperones

GO:0003755|peptidyl-prolyl cis-trans isomerase activity|IEA; GO:0006457|protein folding|IEA; GO:0016853|isomerase activity|IEA

ACL00000105

unclassified

ACL00000106

CDC2

Cell division control protein 2 homolog related cluster

971

1e-104

63% (186/293)

2.7.1.37

Calcium signaling pathway

GO:0000910|cytokinesis|IEA; GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0007049|cell cycle|IEA; GO:0007067|mitosis|IEA; GO:0016740|transferase activity|IEA

ACL00000107

unclassified

ACL00000108

unclassified

ACL00000109

Inosine-5-monophosphate dehydrogenase related protein related cluster

205

1e-15

34% (47/136)

ACL00000110

Hydrolase, isochorismatase family related cluster

324

3e-29

42% (75/178)

GO:0003824|catalytic activity|IEA; GO:0008152|metabolism|IEA

ACL00000112

ATEM1.5; metallopeptidase M24 family protein

413

1e-39

47% (81/169)

ACL00000113

Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C related cluster

188

1e-13

39% (37/94)

6.3.5.-

Translation, ribosomal structure and biogenesis

GO:0006412|protein biosynthesis|IEA; GO:0006450|regulation of translational fidelity|IEA; GO:0016874|ligase activity|IEA; GO:0017068|glutamyl-tRNA(Gln) amidotransferase activity|IEA

ACL00000114

Similar to Mus musculus (Mouse). similar to 60S ribosomal protein L30 isolog related cluster

504

4e-50

60% (90/149)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005634|nucleus|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0007046|ribosome biogenesis|IEA

ACL00000115

unclassified

ACL00000116

unclassified

ACL00000117

LOC56769

Putative nuclear protein related cluster

217

4e-17

39% (45/114)

GO:0005634|nucleus|IEA

ACL00000118

Rpl9

60S ribosomal protein L9 related cluster

524

2e-52

53% (102/190)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000119

Probable electron transfer flavoprotein, beta subunit related cluster

707

1e-73

58% (144/247)

Energy production and conversion

GO:0005489|electron transporter activity|IEA; GO:0006118|electron transport|IEA

ACL00000120

T17F15.100; hypoxia-responsive family protein / zinc finger (C3HC4-type RING finger) family protein

139

5e-08

52% (32/61)

ACL00000121

ETR1

Mitochondrial respiratory function protein homolog related cluster

139

1e-23

40% (30/75)

1.3.1.10

GO:0004024|alcohol dehydrogenase activity, zinc-dependent|IEA; GO:0004319|enoyl-[acyl-carrier protein] reductase (NADPH, B-specific) activity|IEA; GO:0005739|mitochondrion|IEA; GO:0006633|fatty acid biosynthesis|IEA; GO:0008270|zinc ion binding|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000122

unclassified

ACL00000123

Unassigned protein

119

8e-06

28% (41/145)

ACL00000124

Ribosomal protein L14-like protein related cluster

351

1e-32

53% (72/135)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000125

RNA polymerase II subunit 5-mediating protein related cluster

208

2e-16

42% (42/98)

GO:0003714|transcription corepressor activity|TAS; GO:0005515|protein binding|IEA; GO:0005634|nucleus|IEA; GO:0005634|nucleus|TAS; GO:0005665|DNA-directed RNA polymerase II, core complex|TAS; GO:0005737|cytoplasm|TAS; GO:0006357|regulation of transcription from Pol II promoter|TAS; GO:0006457|protein folding|IEA; GO:0009615|response to virus|TAS; GO:0016272|prefoldin complex|IEA

ACL00000126

Ras-related protein Rap-1 related cluster

603

1e-61

73% (121/164)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00000127

translocon-associated protein gamma [Branchiostoma belcheri tsingtaunese]

126

5e-06

24% (35/144)

ACL00000128

unclassified

ACL00000129

multi-domain protein

152

1e-10

27% (49/178)

ACL00000131

unclassified

ACL00000132

rnhA

Ribonuclease H related cluster

169

2e-11

49% (30/61)

GO:0003676|nucleic acid binding|IEA; GO:0004523|ribonuclease H activity|IEA

ACL00000133

Keratin_B2 domain containing protein

111

8e-06

21% (18/83)

ACL00000136

Mapk7

MAP kinase related cluster

298

2e-26

38% (71/185)

2.7.1.37

MAPK signaling pathway

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0004707|MAP kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00000137

NADPH:quinone reductase related cluster

455

2e-44

45% (95/211)

1.6.5.5

GO:0003960|NADPH:quinone reductase activity|IEA; GO:0004024|alcohol dehydrogenase activity, zinc-dependent|IEA; GO:0008270|zinc ion binding|IEA

ACL00000138

HESB like domain containing 2 [Homo sapiens] gb|AAG59854.1| GK004 [Homo sapiens]

310

1e-27

48% (64/133)

ACL00000139

multi-domain protein

112

4e-06

25% (55/217)

ACL00000140

CISY

Citrate synthase, mitochondrial precursor related cluster

803

8e-85

72% (149/206)

2.3.3.1

Energy production and conversion

Citrate cycle (TCA cycle) Glyoxylate and dicarboxylate metabolism

GO:0004108|citrate (Si)-synthase activity|IEA; GO:0004108|citrate (Si)-synthase activity|TAS; GO:0005737|cytoplasm|IEA; GO:0005739|mitochondrion|IEA; GO:0005739|mitochondrion|TAS; GO:0006092|main pathways of carbohydrate metabolism|IEA; GO:0006099|tricarboxylic acid cycle|IEA; GO:0016740|transferase activity|IEA; GO:0046912|transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer|IEA

ACL00000141

PPR-repeat protein related cluster

150

3e-09

27% (49/181)

GO:0005488|binding|IEA

ACL00000142

unclassified

ACL00000143

Unassigned protein

ACL00000144

Bat1a

Nuclear RNA helicase BAT1 related cluster

1347

1e-147

61% (262/425)

GO:0003676|nucleic acid binding|IEA; GO:0004386|helicase activity|IEA; GO:0005524|ATP binding|IEA; GO:0008026|ATP-dependent helicase activity|IEA

ACL00000145

Herpes_gp2 domain containing protein

116

2e-06

26% (49/185)

ACL00000146

YbaK/EbsC protein

366

3e-34

46% (81/176)

ACL00000147

Similar to Homo sapiens (Human). vacuolar proton pump delta polypeptide related cluster

412

1e-39

64% (83/128)

Energy production and conversion

GO:0015986|ATP synthesis coupled proton transport|IEA; GO:0016469|proton-transporting two-sector ATPase complex|IEA; GO:0046933|hydrogen-transporting ATP synthase activity, rotational mechanism|IEA; GO:0046961|hydrogen-transporting ATPase activity, rotational mechanism|IEA

ACL00000148

DnaJ domain containing protein

124

1e-07

46% (20/43)

ACL00000150

DM6 domain containing protein

89

9e-05

24% (29/117)

ACL00000151

Efhd2

EF-hand domain-containing protein 2 related cluster

367

2e-34

50% (79/157)

GO:0005509|calcium ion binding|IEA

ACL00000152

adhC

Alcohol dehydrogenase class III related cluster

627

2e-64

72% (112/155)

1.2.1.1 1.1.1.1

Energy production and conversion

Bile acid biosynthesis Fatty acid metabolism Glycerolipid metabolism Glycolysis / Gluconeogenesis Methane metabolism Pyruvate metabolism Tyrosine metabolism

GO:0004022|alcohol dehydrogenase activity|IEA; GO:0004024|alcohol dehydrogenase activity, zinc-dependent|IEA; GO:0008270|zinc ion binding|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000153

elovl6

Fatty acyl elongase related cluster

427

5e-41

37% (89/235)

GO:0016021|integral to membrane|IEA; GO:0016021|integral to membrane|TAS; GO:0016747|transferase activity, transferring groups other than amino-acyl groups|IDA; GO:0030176|integral to endoplasmic reticulum membrane|IDA; GO:0030497|fatty acid elongation|IDA

ACL00000154

multi-domain protein

124

3e-07

21% (71/335)

ACL00000155

Ubiquitin-conjugating enzyme E2 related cluster

629

9e-65

70% (109/154)

6.3.2.19

Posttranslational modification, protein turnover, chaperones

GO:0004840|ubiquitin conjugating enzyme activity|IEA; GO:0004842|ubiquitin-protein ligase activity|IEA; GO:0006464|protein modification|IEA; GO:0006512|ubiquitin cycle|IEA; GO:0016874|ligase activity|IEA

ACL00000156

Naca

NASCENT polypeptide associated complex alpha subunit related cluster

420

1e-40

51% (93/182)

Transcription

GO:0005737|cytoplasm|TAS; GO:0005854|nascent polypeptide-associated complex|TAS; GO:0006412|protein biosynthesis|TAS; GO:0006444|nascent polypeptide association|TAS

ACL00000157

Unassigned protein

ACL00000158

SET domain protein 123 related cluster

247

3e-20

25% (79/314)

General function prediction only

ACL00000159

unclassified

ACL00000161

CPXB

Bifunctional P-450:NADPH-P450 reductase related cluster

273

2e-23

41% (65/155)

1.14.14.1

Inorganic ion transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0003958|NADPH-hemoprotein reductase activity|IEA; GO:0004497|monooxygenase activity|IEA; GO:0005489|electron transporter activity|IEA; GO:0006118|electron transport|IEA; GO:0010181|FMN binding|IEA; GO:0016020|membrane|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0050381|unspecific monooxygenase activity|IEA

ACL00000162

Unassigned protein

ACL00000163

Guanylate cyclase-activating protein 3 related cluster

194

3e-14

36% (41/113)

GO:0005509|calcium ion binding|IEA

ACL00000165

unclassified

ACL00000166

UBX domain containing protein

94

2e-05

18% (15/80)

ACL00000167

Coactosin related cluster

320

9e-29

45% (67/146)

GO:0003779|actin binding|IEA; GO:0005622|intracellular|IEA; GO:0005856|cytoskeleton|IEA

ACL00000168

Unknown EST

86

3e-11

29% (13/44)

ACL00000169

CG3320

Ras-related protein Rab-1A related cluster

659

4e-68

71% (121/170)

GO:0005525|GTP binding|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0005794|Golgi apparatus|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00000170

unclassified

ACL00000171

F8K7.20; F-box family protein

128

9e-07

46% (23/49)

ACL00000172

Ras-related protein Rab7 related cluster

394

1e-83

91% (75/82)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00000173

ZnF_ZZ domain containing protein

113

7e-08

36% (16/44)

ACL00000174

unclassified

ACL00000175

unclassified

ACL00000176

Adenylate kinase related cluster

683

9e-71

60% (134/221)

2.7.4.3

Nucleotide transport and metabolism

Purine metabolism

GO:0004017|adenylate kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA; GO:0016776|phosphotransferase activity, phosphate group as acceptor|IEA

ACL00000177

unclassified

ACL00000179

DAPT

Dihydroxyacetone phosphate acyltransferase related cluster

195

6e-14

24% (107/437)

2.3.1.42

Lipid transport and metabolism

Glycerolipid metabolism

GO:0003824|catalytic activity|IDA; GO:0005777|peroxisome|IEA; GO:0005782|peroxisomal matrix|TAS; GO:0008152|metabolism|IEA; GO:0008415|acyltransferase activity|IEA; GO:0008611|ether lipid biosynthesis|IMP; GO:0016020|membrane|IEA; GO:0016044|membrane organization and biogenesis|IMP; GO:0016287|glycerone-phosphate O-acyltransferase activity|IDA; GO:0016287|glycerone-phosphate O-acyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00000181

5'-AMP-activated protein kinase, gamma-2 subunit related cluster

163

2e-10

19% (80/403)

GO:0005554|molecular_function unknown|ND; GO:0006633|fatty acid biosynthesis|IEA; GO:0006695|cholesterol biosynthesis|NAS; GO:0008372|cellular_component unknown|ND

ACL00000182

Putative transmembrane protein related cluster

147

3e-09

42% (35/82)

GO:0008152|metabolism|IEA; GO:0016021|integral to membrane|IEA

ACL00000183

unclassified

ACL00000184

Epoxidase subunit A related cluster

308

1e-27

43% (64/146)

ACL00000185

Unknown EST

49

6e-08

43% (13/30)

ACL00000186

PA domain containing protein

115

2e-06

26% (18/67)

ACL00000188

Putative mRNA capping enzyme subunit related cluster

217

1e-16

30% (67/217)

GO:0004651|polynucleotide 5'-phosphatase activity|IEA; GO:0005634|nucleus|IEA; GO:0006370|mRNA capping|IEA; GO:0016787|hydrolase activity|IEA

ACL00000191

T17F3.17; CBS domain-containing protein

163

1e-10

26% (60/225)

General function prediction only

ACL00000192

Polyubiquitin related cluster

748

2e-78

86% (152/176)

ACL00000193

Herpes_UL56 domain containing protein

110

7e-06

25% (37/145)

ACL00000194

Histone H3 related cluster

445

2e-43

69% (94/135)

Chromatin structure and dynamics

GO:0000786|nucleosome|IEA; GO:0003677|DNA binding|IEA; GO:0005634|nucleus|IEA; GO:0005694|chromosome|IEA; GO:0006334|nucleosome assembly|IEA; GO:0007001|chromosome organization and biogenesis (sensu Eukaryota)|IEA

ACL00000195

unclassified

ACL00000196

AFR526Cp

AFR526Cp; syntenic homolog of Saccharomyces cerevisiae YOR298C-A (MBF1) [KO:K03627]

204

1e-15

53% (44/83)

Transcription

ACL00000198

CPDc domain containing protein

103

1e-06

35% (23/65)

ACL00000200

fusA

Elongation factor G, mitochondrial precursor related cluster

504

3e-50

51% (108/210)

3.6.5.3

Translation, ribosomal structure and biogenesis

GO:0003746|translation elongation factor activity|IEA; GO:0005525|GTP binding|IEA; GO:0005739|mitochondrion|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006414|translational elongation|IEA

ACL00000201

unclassified

ACL00000202

Prohibitin related cluster

682

1e-70

54% (136/248)

Posttranslational modification, protein turnover, chaperones

GO:0001302|replicative cell aging|IMP; GO:0005739|mitochondrion|IDA; GO:0005743|mitochondrial inner membrane|TAS; GO:0006508|proteolysis and peptidolysis|IMP

ACL00000203

unclassified

ACL00000204

Enoyl CoA hydratase-like protein related cluster

478

3e-47

44% (101/229)

Lipid transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0008152|metabolism|IEA

ACL00000205

multi-domain protein

127

7e-08

21% (33/157)

ACL00000206

EIF4EBP3

Eukaryotic translation initiation factor 4E binding protein 3 related cluster

219

3e-17

55% (44/80)

GO:0006417|regulation of protein biosynthesis|IEA; GO:0006445|regulation of translation|IEA; GO:0008190|eukaryotic initiation factor 4E binding|IEA; GO:0016281|eukaryotic translation initiation factor 4F complex|NAS; GO:0016478|negative regulation of translation|NAS; GO:0017148|negative regulation of protein biosynthesis|IEA; GO:0030371|translation repressor activity|NAS; GO:0045947|negative regulation of translational initiation|IEA

ACL00000207

thiH

ThiH protein related cluster

324

1e-29

42% (74/176)

GO:0003824|catalytic activity|IEA; GO:0005506|iron ion binding|IEA

ACL00000208

TT_ORF1 domain containing protein

111

4e-06

37% (35/93)

ACL00000209

MGC72590

MGC72590; similar to endoplasmic reticulum chaperone SIL1 homolog

243

8e-20

29% (70/240)

ACL00000211

unclassified

ACL00000212

MDHC

Malate dehydrogenase, cytoplasmic related cluster

405

4e-88

63% (82/130)

1.1.1.37

Energy production and conversion

GO:0006099|tricarboxylic acid cycle|IEA; GO:0006100|tricarboxylic acid cycle intermediate metabolism|IEA; GO:0006108|malate metabolism|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016615|malate dehydrogenase activity|IEA; GO:0030060|L-malate dehydrogenase activity|IEA

ACL00000213

RNA-binding protein precursor related cluster

212

2e-16

41% (41/100)

General function prediction only

GO:0003723|RNA binding|IEA

ACL00000214

ivd2

Putative isovaleryl-CoA dehydrogenase protein related cluster

309

2e-27

64% (57/88)

1.3.99.10

Lipid transport and metabolism

Valine, leucine and isoleucine degradation

GO:0003995|acyl-CoA dehydrogenase activity|IEA; GO:0006118|electron transport|IEA; GO:0008470|isovaleryl-CoA dehydrogenase activity|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000215

ivd2

Isovaleryl-CoA dehydrogenase related cluster

1105

1e-120

79% (210/265)

1.3.99.10

Lipid transport and metabolism

Valine, leucine and isoleucine degradation

GO:0003995|acyl-CoA dehydrogenase activity|IEA; GO:0006118|electron transport|IEA; GO:0008470|isovaleryl-CoA dehydrogenase activity|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000216

UGDH

UDP-glucose 6-dehydrogenase related cluster

577

1e-58

51% (112/217)

1.1.1.22

Cell wall/membrane/envelope biogenesis

Nucleotide sugars metabolism Pentose and glucuronate interconversions Starch and sucrose metabolism

GO:0003979|UDP-glucose 6-dehydrogenase activity|IEA; GO:0003979|UDP-glucose 6-dehydrogenase activity|TAS; GO:0006118|electron transport|IEA; GO:0007224|smoothened signaling pathway|TAS; GO:0007427|tracheal cell migration (sensu Insecta)|TAS; GO:0007428|primary tracheal branching (sensu Insecta)|TAS; GO:0007507|heart development|NAS; GO:0008543|fibroblast growth factor receptor signaling pathway|TAS; GO:0015012|heparan sulfate proteoglycan biosynthesis|TAS; GO:0015014|heparan sulfate proteoglycan biosynthesis, polysaccharide chain biosynthesis|NAS; GO:0016055|Wnt receptor signaling pathway|TAS; GO:0016491|oxidoreductase activity|IEA; GO:0030206|chondroitin sulfate biosynthesis|TAS

ACL00000218

PLAC8

Placenta-specific gene 8 protein related cluster

136

9e-08

33% (33/99)

ACL00000219

multi-domain protein

124

2e-07

23% (20/85)

ACL00000220

LOC385608

40S ribosomal protein S10 related cluster

267

1e-22

41% (58/140)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA

ACL00000222

Histone H4 related cluster

422

6e-41

96% (82/85)

Chromatin structure and dynamics

GO:0000786|nucleosome|IEA; GO:0003677|DNA binding|IEA; GO:0005634|nucleus|IEA; GO:0005694|chromosome|IEA; GO:0006334|nucleosome assembly|IEA; GO:0007001|chromosome organization and biogenesis (sensu Eukaryota)|IEA

ACL00000223

multi-domain protein

127

1e-07

19% (60/313)

ACL00000224

unclassified

ACL00000225

Unassigned protein

ACL00000226

FCAALL.203; fumarylacetoacetate hydrolase family protein

648

5e-67

64% (126/196)

ACL00000227

unclassified

ACL00000228

Calcium-dependent protein kinase, isoform 2 related cluster

182

5e-13

33% (56/165)

2.7.1.-

Benzoate degradation via CoA ligation Inositol phosphate metabolism Nicotinate and nicotinamide metabolism Starch and sucrose metabolism

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005509|calcium ion binding|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016740|transferase activity|IEA

ACL00000229

Translationally controlled tumor protein homolog related cluster

358

2e-33

42% (72/169)

GO:0005554|molecular_function unknown|IEA; GO:0005737|cytoplasm|IEA; GO:0006457|protein folding|IEA; GO:0051082|unfolded protein binding|IEA

ACL00000230

Penicillin binding protein related cluster

693

5e-72

68% (139/204)

2.4.2.-

Cell wall/membrane/envelope biogenesis

GO:0003824|catalytic activity|IEA; GO:0008658|penicillin binding|IEA; GO:0009252|peptidoglycan biosynthesis|IEA; GO:0009273|cell wall biosynthesis (sensu Bacteria)|IEA; GO:0009274|cell wall (sensu Bacteria)|IEA

ACL00000231

GPMA

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase related cluster

412

9e-94

80% (76/94)

5.4.2.1

Carbohydrate transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0004619|phosphoglycerate mutase activity|IEA; GO:0006096|glycolysis|IEA; GO:0008152|metabolism|IEA; GO:0016853|isomerase activity|IEA; GO:0016868|intramolecular transferase activity, phosphotransferases|IEA; GO:0046538|2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity|IEA

ACL00000232

Vesicle-associated membrane protein 712 related cluster

430

1e-41

40% (78/191)

GO:0006810|transport|IEA; GO:0015031|protein transport|IEA; GO:0016021|integral to membrane|IEA

ACL00000234

Rps27

40S ribosomal protein S27 related cluster

377

5e-36

83% (67/80)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003723|RNA binding|TAS; GO:0003735|structural constituent of ribosome|IEA; GO:0003735|structural constituent of ribosome|TAS; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0005843|cytosolic small ribosomal subunit (sensu Eukaryota)|TAS; GO:0006412|protein biosynthesis|IEA; GO:0006412|protein biosynthesis|TAS; GO:0007165|signal transduction|TAS; GO:0008270|zinc ion binding|TAS; GO:0008283|cell proliferation|TAS

ACL00000235

Putative GTP-binding protein related cluster

170

3e-33

46% (34/73)

General function prediction only

ACL00000236

hpt

Hypoxanthine-guanine phosphoribosyltransferase related cluster

419

2e-40

47% (78/165)

2.4.2.8

Nucleotide transport and metabolism

Purine metabolism

GO:0004422|hypoxanthine phosphoribosyltransferase activity|IEA; GO:0005737|cytoplasm|IEA; GO:0006166|purine ribonucleoside salvage|IEA; GO:0009116|nucleoside metabolism|IEA; GO:0016740|transferase activity|IEA; GO:0016757|transferase activity, transferring glycosyl groups|IEA

ACL00000237

Adenylosuccinate lyase related cluster

101

6e-64

43% (20/46)

Nucleotide transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0004018|adenylosuccinate lyase activity|IEA; GO:0009152|purine ribonucleotide biosynthesis|IEA; GO:0016829|lyase activity|IEA

ACL00000238

SYD

Aspartyl-tRNA synthetase related cluster

258

4e-22

42% (54/126)

6.1.1.12

Translation, ribosomal structure and biogenesis

Alanine and aspartate metabolism

GO:0003676|nucleic acid binding|IEA; GO:0004046|aminoacylase activity|TAS; GO:0004812|tRNA ligase activity|IEA; GO:0004815|aspartate-tRNA ligase activity|IEA; GO:0004815|aspartate-tRNA ligase activity|TAS; GO:0005524|ATP binding|IEA; GO:0005625|soluble fraction|TAS; GO:0005737|cytoplasm|IEA; GO:0005737|cytoplasm|TAS; GO:0006412|protein biosynthesis|IEA; GO:0006412|protein biosynthesis|TAS; GO:0006418|tRNA aminoacylation for protein translation|IEA; GO:0006422|aspartyl-tRNA aminoacylation|IEA; GO:0006422|aspartyl-tRNA aminoacylation|TAS; GO:0006461|protein complex assembly|TAS; GO:0016874|ligase activity|IEA

ACL00000239

F14P3.15; proteasome family protein

354

1e-32

31% (81/261)

ACL00000240

Co-chaperone GrpE, putative related cluster

345

1e-31

43% (69/160)

Posttranslational modification, protein turnover, chaperones

GO:0000774|adenyl-nucleotide exchange factor activity|IEA; GO:0005739|mitochondrion|IEA; GO:0006457|protein folding|IEA; GO:0042803|protein homodimerization activity|IEA; GO:0051082|unfolded protein binding|IEA; GO:0051087|chaperone binding|IEA

ACL00000241

DUF566 domain containing protein

110

6e-06

25% (42/162)

ACL00000242

Ribosomal protein L30 related cluster

476

2e-47

81% (91/112)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000245

SNF4

Nuclear protein SNF4 related cluster

264

4e-22

25% (83/322)

GO:0005634|nucleus|IDA; GO:0005634|nucleus|IEA; GO:0005737|cytoplasm|IDA; GO:0005886|plasma membrane|IDA; GO:0005975|carbohydrate metabolism|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006357|regulation of transcription from Pol II promoter|IGI; GO:0007031|peroxisome organization and biogenesis|IMP; GO:0030295|protein kinase activator activity|IGI

ACL00000247

Unassigned protein

ACL00000249

60S ribosomal protein L12 related cluster

544

8e-55

61% (102/167)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000250

Hgd

Homogentisate 1,2-dioxygenase related cluster

1515

1e-167

67% (286/426)

1.13.11.5

Secondary metabolites biosynthesis, transport and catabolism

Styrene degradation Tyrosine metabolism

GO:0004411|homogentisate 1,2-dioxygenase activity|IEA; GO:0006559|L-phenylalanine catabolism|IEA; GO:0006570|tyrosine metabolism|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016702|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|IEA

ACL00000251

Probable small nuclear ribonucleoprotein F related cluster

344

6e-32

72% (63/87)

Transcription

GO:0000398|nuclear mRNA splicing, via spliceosome|IEA; GO:0003723|RNA binding|IEA; GO:0005634|nucleus|IEA; GO:0005732|small nucleolar ribonucleoprotein complex|IEA; GO:0006397|mRNA processing|IEA; GO:0008248|pre-mRNA splicing factor activity|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00000254

Rps7

40S ribosomal protein S7 related cluster

578

9e-59

61% (117/190)

Ribosome

GO:0003723|RNA binding|TAS; GO:0003735|structural constituent of ribosome|TAS; GO:0005843|cytosolic small ribosomal subunit (sensu Eukaryota)|TAS; GO:0006412|protein biosynthesis|TAS

ACL00000255

COP-coated vesicle membrane protein P24 homolog related cluster

243

8e-20

34% (56/162)

GO:0006886|intracellular protein transport|IEA; GO:0008320|protein carrier activity|IEA; GO:0016020|membrane|IEA

ACL00000257

[T] COG0589 Universal stress protein UspA and related nucleotide-binding proteins

157

1e-10

35% (32/89)

Signal transduction mechanisms

ACL00000258

CBS domain protein related cluster

182

1e-12

23% (58/252)

General function prediction only

ACL00000259

C-24(28) sterol reductase, putative related cluster

281

7e-25

69% (46/66)

GO:0016020|membrane|IEA

ACL00000260

Peroxidase ppod2 related cluster

122

4e-06

32% (38/117)

GO:0004601|peroxidase activity|IEA

ACL00000262

multi-domain protein

116

2e-06

46% (27/58)

ACL00000263

Small GTP binding protein RAB6, putative related cluster

164

5e-11

31% (46/146)

General function prediction only

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00000264

Ranbp1

Ran-specific GTPase-activating protein related cluster

396

1e-37

63% (76/119)

Intracellular trafficking, secretion, and vesicular transport

GO:0005092|GDP-dissociation inhibitor activity|TAS; GO:0005096|GTPase activator activity|IEA; GO:0007165|signal transduction|TAS; GO:0008536|RAN protein binding|TAS

ACL00000265

VATB

Vacuolar ATP synthase subunit B related cluster

442

0.0

77% (88/114)

3.6.3.14

Energy production and conversion

ATP synthesis Oxidative phosphorylation

GO:0005524|ATP binding|IEA; GO:0005737|cytoplasm|IEA; GO:0006754|ATP biosynthesis|IEA; GO:0008553|hydrogen-exporting ATPase activity, phosphorylative mechanism|IEA; GO:0015078|hydrogen ion transporter activity|IEA; GO:0015986|ATP synthesis coupled proton transport|IEA; GO:0015988|energy coupled proton transport, against electrochemical gradient|IEA; GO:0015992|proton transport|IEA; GO:0016469|proton-transporting two-sector ATPase complex|IEA; GO:0016787|hydrolase activity|IEA; GO:0046933|hydrogen-transporting ATP synthase activity, rotational mechanism|IEA; GO:0046961|hydrogen-transporting ATPase activity, rotational mechanism|IEA

ACL00000266

Ribosomal protein S18 related cluster

585

1e-59

70% (107/151)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003723|RNA binding|IEA; GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00000267

multi-domain protein

128

8e-08

22% (56/253)

ACL00000268

EIF3S7

Eukaryotic translation initiation factor 3 subunit 7 related cluster

945

1e-101

48% (191/395)

GO:0003743|translation initiation factor activity|IEA; GO:0003743|translation initiation factor activity|TAS; GO:0005852|eukaryotic translation initiation factor 3 complex|TAS; GO:0006412|protein biosynthesis|IEA; GO:0006413|translational initiation|IEA; GO:0006446|regulation of translational initiation|TAS

ACL00000270

Membrane associated progesterone receptor component 1 related cluster

147

8e-09

26% (38/141)

GO:0004872|receptor activity|IEA; GO:0005496|steroid binding|IEA; GO:0005496|steroid binding|TAS; GO:0005792|microsome|IEA; GO:0005887|integral to plasma membrane|TAS; GO:0016021|integral to membrane|IEA

ACL00000271

60S acidic ribosomal protein P1 related cluster

127

1e-06

43% (27/62)

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006414|translational elongation|IEA

ACL00000273

MYLK

Myosin light chain kinase related cluster

965

1e-103

70% (183/260)

2.7.1.117

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0004687|myosin-light-chain kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016740|transferase activity|IEA

ACL00000274

Rpl24

60S ribosomal protein L24 related cluster

279

6e-24

55% (54/98)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003723|RNA binding|ISS; GO:0003735|structural constituent of ribosome|IEA; GO:0003735|structural constituent of ribosome|ISS; GO:0005622|intracellular|IEA; GO:0005737|cytoplasm|ISS; GO:0005840|ribosome|IEA; GO:0005842|cytosolic large ribosomal subunit (sensu Eukaryota)|ISS; GO:0006412|protein biosynthesis|IEA; GO:0006412|protein biosynthesis|ISS

ACL00000275

40S ribosomal protein S15A related cluster

544

5e-55

81% (105/129)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000276

Unknown EST

81

3e-09

36% (12/33)

ACL00000279

Ribosomal protein S29-like related cluster

235

2e-19

69% (39/56)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000280

Dihydropteridine reductase related cluster

601

2e-61

55% (125/224)

GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000281

UbcB related cluster

503

3e-50

64% (95/148)

GO:0004840|ubiquitin conjugating enzyme activity|IEA; GO:0006464|protein modification|IEA; GO:0006512|ubiquitin cycle|IEA

ACL00000282

multi-domain protein

126

1e-07

28% (26/92)

ACL00000284

Universal stress protein family related cluster

133

1e-07

49% (26/53)

Signal transduction mechanisms

GO:0006950|response to stress|IEA

ACL00000286

BCAS2

BCAS2; breast carcinoma amplified sequence 2

224

1e-17

28% (51/182)

ACL00000288

40S ribosomal protein S19-3 related cluster

515

1e-51

69% (94/136)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000289

PSMD8

26S proteasome regulatory particle non-ATPase subunit12 related cluster

462

3e-45

41% (101/245)

Proteasome

GO:0005829|cytosol|IEA; GO:0005838|proteasome regulatory particle (sensu Eukaryota)|IEA; GO:0006508|proteolysis and peptidolysis|IEA

ACL00000290

F14P22.40; universal stress protein (USP) family protein

177

2e-12

53% (33/62)

Signal transduction mechanisms

ACL00000291

unclassified

ACL00000294

Putative dehydrogenase related cluster

868

6e-92

53% (176/326)

1.1.1.28

Pyruvate metabolism

GO:0006564|L-serine biosynthesis|IEA; GO:0016616|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|IEA

ACL00000295

Eef1b2

Elongation factor 1-beta related cluster

366

5e-34

37% (83/224)

Translation, ribosomal structure and biogenesis

GO:0003746|translation elongation factor activity|IEA; GO:0003746|translation elongation factor activity|NAS; GO:0005853|eukaryotic translation elongation factor 1 complex|IEA; GO:0005853|eukaryotic translation elongation factor 1 complex|NAS; GO:0006412|protein biosynthesis|IEA; GO:0006414|translational elongation|IEA; GO:0006414|translational elongation|NAS

ACL00000296

COX5

Cytochrome c oxidase polypeptide V related cluster

186

2e-13

54% (34/62)

1.9.3.1

Oxidative phosphorylation

GO:0004129|cytochrome-c oxidase activity|IEA; GO:0005739|mitochondrion|IEA; GO:0005740|mitochondrial membrane|IEA; GO:0006118|electron transport|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0019866|inner membrane|IEA

ACL00000297

multi-domain protein

122

4e-07

16% (48/283)

ACL00000298

60S ribosomal protein L6 related cluster

211

1e-45

43% (48/110)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000299

Copper chaperone related cluster

147

3e-09

46% (27/58)

GO:0030001|metal ion transport|IEA; GO:0046872|metal ion binding|IEA

ACL00000300

LOC147346

60S ribosomal protein L7a related cluster

719

7e-75

64% (141/220)

Translation, ribosomal structure and biogenesis

GO:0003723|RNA binding|TAS; GO:0003735|structural constituent of ribosome|TAS; GO:0005842|cytosolic large ribosomal subunit (sensu Eukaryota)|TAS; GO:0006412|protein biosynthesis|TAS

ACL00000301

multi-domain protein

187

1e-14

21% (83/393)

ACL00000302

Elongation factor EF-2 related cluster

466

1e-45

41% (115/274)

Translation, ribosomal structure and biogenesis

GO:0003746|translation elongation factor activity|IEA; GO:0005525|GTP binding|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006414|translational elongation|IEA

ACL00000303

PROC1

Pyrroline-5-carboxylate reductase related cluster

627

3e-64

51% (134/262)

1.5.1.2

Amino acid transport and metabolism

Arginine and proline metabolism Urea cycle and metabolism of amino groups

GO:0004735|pyrroline-5-carboxylate reductase activity|IEA; GO:0006561|proline biosynthesis|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000306

RAB32

Ras-related protein Rab-32 related cluster

564

5e-57

49% (112/227)

GO:0005525|GTP binding|IEA; GO:0005739|mitochondrion|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00000309

LOC268695

Ribosomal protein L27a related cluster

585

9e-60

71% (107/149)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00000310

unclassified

ACL00000312

multi-domain protein

126

1e-07

25% (49/190)

ACL00000313

Rpl32

60S ribosomal protein L32 related cluster

418

2e-40

67% (75/111)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003723|RNA binding|NR; GO:0003735|structural constituent of ribosome|NR; GO:0005842|cytosolic large ribosomal subunit (sensu Eukaryota)|NR

ACL00000314

RPL5

60S ribosomal protein L5 related cluster

870

2e-92

58% (174/298)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003723|RNA binding|TAS; GO:0003735|structural constituent of ribosome|IEA; GO:0003735|structural constituent of ribosome|TAS; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0005842|cytosolic large ribosomal subunit (sensu Eukaryota)|TAS; GO:0006412|protein biosynthesis|IEA; GO:0006412|protein biosynthesis|TAS; GO:0008097|5S rRNA binding|IEA; GO:0019843|rRNA binding|IEA

ACL00000315

DUF566 domain containing protein

111

5e-06

16% (29/174)

ACL00000318

CBS domain protein related cluster

171

3e-11

22% (71/317)

General function prediction only

ACL00000320

ATPG

ATP synthase gamma chain, mitochondrial precursor related cluster

433

1e-41

38% (104/271)

3.6.3.14

Energy production and conversion

ATP synthesis Oxidative phosphorylation

GO:0005739|mitochondrion|IEA; GO:0006754|ATP biosynthesis|IEA; GO:0015078|hydrogen ion transporter activity|IEA; GO:0015986|ATP synthesis coupled proton transport|IEA; GO:0015992|proton transport|IEA; GO:0016020|membrane|IEA; GO:0016469|proton-transporting two-sector ATPase complex|IEA; GO:0016787|hydrolase activity|IEA; GO:0046933|hydrogen-transporting ATP synthase activity, rotational mechanism|IEA; GO:0046961|hydrogen-transporting ATPase activity, rotational mechanism|IEA

ACL00000321

unclassified

ACL00000322

Rps11

40S ribosomal protein S11 related cluster

576

1e-58

67% (110/164)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00000325

ylbB

YLBB protein related cluster

206

8e-16

37% (51/136)

ACL00000328

Rps27

40S ribosomal protein S27 related cluster

377

7e-36

83% (67/80)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003723|RNA binding|TAS; GO:0003735|structural constituent of ribosome|IEA; GO:0003735|structural constituent of ribosome|TAS; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0005843|cytosolic small ribosomal subunit (sensu Eukaryota)|TAS; GO:0006412|protein biosynthesis|IEA; GO:0006412|protein biosynthesis|TAS; GO:0007165|signal transduction|TAS; GO:0008270|zinc ion binding|TAS; GO:0008283|cell proliferation|TAS

ACL00000329

DUF566 domain containing protein

117

9e-07

26% (36/136)

ACL00000330

40S ribosomal protein, contains C-terminal domain related cluster

777

1e-81

69% (155/222)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003676|nucleic acid binding|IEA; GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0015935|small ribosomal subunit|IEA

ACL00000331

Iron/ascorbate oxidoreductase related cluster

169

5e-11

24% (74/299)

GO:0016491|oxidoreductase activity|IEA

ACL00000333

Profilins IA/IB related cluster

635

3e-65

100% (125/125)

ACL00000344

Gapd

Glyceraldehyde-3-phosphate dehydrogenase related cluster

59

1e-114

78% (11/14)

1.2.1.12

Carbohydrate transport and metabolism

Alzheimer's disease Dentatorubropallidoluysian atrophy (DRPLA) Glycolysis / Gluconeogenesis Huntington's disease Neurodegenerative Disorders

GO:0004365|glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity|IEA; GO:0006006|glucose metabolism|IEA; GO:0006096|glycolysis|IEA; GO:0008943|glyceraldehyde-3-phosphate dehydrogenase activity|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000346

ADP,ATP carrier protein 1, mitochondrial precursor related cluster

1181

1e-128

74% (225/302)

GO:0005215|transporter activity|IEA; GO:0005488|binding|IEA; GO:0005739|mitochondrion|IEA; GO:0005743|mitochondrial inner membrane|IEA; GO:0006810|transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0019866|inner membrane|IEA

ACL00000347

Ribosomal protein S8 related cluster

557

3e-56

50% (121/239)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00000350

PIP

Probable proline iminopeptidase related cluster

958

1e-102

57% (177/308)

3.4.11.5

Arginine and proline metabolism

GO:0003824|catalytic activity|IEA; GO:0004177|aminopeptidase activity|IEA; GO:0005737|cytoplasm|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0006725|aromatic compound metabolism|IEA; GO:0016787|hydrolase activity|IEA; GO:0016804|prolyl aminopeptidase activity|IEA

ACL00000351

unclassified

ACL00000352

unclassified

ACL00000353

rhtB

RhtB family transporter related cluster

360

8e-34

63% (70/110)

GO:0005293|lysine permease activity|IEA; GO:0006865|amino acid transport|IEA; GO:0016020|membrane|IEA

ACL00000354

Unassigned protein

ACL00000355

unclassified

ACL00000356

unclassified

ACL00000359

ctpD

Pilus assembly protein related cluster

710

3e-74

73% (145/198)

Type II secretion system

GO:0009306|protein secretion|IEA; GO:0016020|membrane|IEA

ACL00000360

ctpD

Pilus assembly protein related cluster

293

3e-26

68% (65/95)

Type II secretion system

GO:0009306|protein secretion|IEA; GO:0016020|membrane|IEA

ACL00000361

unclassified

ACL00000362

Unassigned protein

ACL00000363

aco2

Aconitase related cluster

117

7e-06

50% (25/50)

GO:0003994|aconitate hydratase activity|IEA; GO:0005739|mitochondrion|IEA; GO:0006099|tricarboxylic acid cycle|IEA; GO:0008152|metabolism|IEA; GO:0016829|lyase activity|IEA; GO:0016836|hydro-lyase activity|IEA

ACL00000364

ACON

Aconitate hydratase, mitochondrial precursor related cluster

476

2e-47

71% (86/121)

4.2.1.3

GO:0003994|aconitate hydratase activity|IEA; GO:0005739|mitochondrion|IEA; GO:0006099|tricarboxylic acid cycle|IEA; GO:0008152|metabolism|IEA; GO:0016829|lyase activity|IEA; GO:0016836|hydro-lyase activity|IEA

ACL00000365

unclassified

ACL00000366

unclassified

ACL00000368

P_proprotein domain containing protein

128

1e-08

42% (27/64)

ACL00000369

unclassified

ACL00000370

unclassified

ACL00000371

kup1

Kup related cluster

751

4e-79

89% (149/167)

GO:0006810|transport|IEA; GO:0006813|potassium ion transport|IEA; GO:0015079|potassium ion transporter activity|IEA; GO:0015293|symporter activity|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0019866|inner membrane|IEA

ACL00000372

ATP synthase, subunit I related cluster

341

1e-31

64% (67/104)

ACL00000373

30 kDa heat shock protein related cluster

183

9e-13

31% (44/139)

Posttranslational modification, protein turnover, chaperones

GO:0006457|protein folding|IEA; GO:0006986|response to unfolded protein|IEA

ACL00000374

Histidinol-phosphate aminotransferase-like protein related cluster

90

3e-09

32% (17/53)

2.6.1.9

Histidine metabolism Novobiocin biosynthesis Phenylalanine metabolism Phenylalanine, tyrosine and tryptophan biosynthesis Tyrosine metabolism

ACL00000375

HIS7

Imidazoleglycerol-phosphate dehydratase related cluster

211

1e-16

44% (51/115)

4.2.1.19

GO:0000105|histidine biosynthesis|IEA; GO:0003824|catalytic activity|IEA; GO:0004401|histidinol-phosphatase activity|IEA; GO:0004424|imidazoleglycerol-phosphate dehydratase activity|IEA; GO:0008152|metabolism|IEA; GO:0016829|lyase activity|IEA

ACL00000376

CG5193

Transcription initiation factor IIB related cluster

317

3e-28

29% (81/274)

Transcription

Basal transcription factors

GO:0003702|RNA polymerase II transcription factor activity|IEA; GO:0005634|nucleus|IEA; GO:0005667|transcription factor complex|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006367|transcription initiation from Pol II promoter|IEA

ACL00000377

unclassified

ACL00000379

ATP-dependent DNA helicase II, 70 kDa subunit related cluster

237

9e-20

41% (49/117)

GO:0003677|DNA binding|IEA; GO:0003690|double-stranded DNA binding|TAS; GO:0004003|ATP-dependent DNA helicase activity|IEA; GO:0004003|ATP-dependent DNA helicase activity|TAS; GO:0004386|helicase activity|IEA; GO:0005624|membrane fraction|TAS; GO:0005634|nucleus|IEA; GO:0005634|nucleus|TAS; GO:0006266|DNA ligation|TAS; GO:0006281|DNA repair|IEA; GO:0006303|double-strand break repair via nonhomologous end-joining|IEA; GO:0006303|double-strand break repair via nonhomologous end-joining|TAS; GO:0006310|DNA recombination|IEA; GO:0006310|DNA recombination|NR

ACL00000380

unclassified

ACL00000382

Protein kinase Npk related cluster

191

2e-14

41% (36/86)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0004713|protein-tyrosine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00000384

Unassigned protein

ACL00000385

zgc:66108

Similar to growth hormone inducible transmembrane protein related cluster

227

1e-17

27% (61/224)

ACL00000387

unclassified

ACL00000388

LIM domain containing protein

89

5e-05

48% (14/29)

ACL00000389

Vesicle transport v-SNARE 11 related cluster

183

4e-13

26% (46/171)

GO:0005794|Golgi apparatus|IEA; GO:0006810|transport|IEA; GO:0006886|intracellular protein transport|IEA; GO:0015031|protein transport|IEA; GO:0016021|integral to membrane|IEA

ACL00000390

Histidine kinase DhkJ related cluster

429

5e-42

66% (85/127)

Signal transduction mechanisms

GO:0000155|two-component sensor molecule activity|IEA; GO:0000156|two-component response regulator activity|IEA; GO:0000160|two-component signal transduction system (phosphorelay)|IEA; GO:0003677|DNA binding|IEA; GO:0004871|signal transducer activity|IEA; GO:0005524|ATP binding|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0007165|signal transduction|IEA; GO:0007600|sensory perception|IEA; GO:0016020|membrane|IEA; GO:0016301|kinase activity|IEA; GO:0016310|phosphorylation|IEA; GO:0016772|transferase activity, transferring phosphorus-containing groups|IEA

ACL00000392

SMPDL3A

Acid sphingomyelinase-like phosphodiesterase 3a precursor related cluster

473

3e-46

31% (124/395)

GO:0000004|biological_process unknown|ND; GO:0005515|protein binding|IPI; GO:0005576|extracellular region|NR; GO:0005975|carbohydrate metabolism|IEA; GO:0016787|hydrolase activity|IEA; GO:0016798|hydrolase activity, acting on glycosyl bonds|IEA

ACL00000393

Unknown EST

228

1e-21

46% (49/106)

ACL00000395

SAHH

Adenosylhomocysteinase related cluster

356

1e-179

72% (67/92)

3.3.1.1

Methionine metabolism Selenoamino acid metabolism

GO:0004013|adenosylhomocysteinase activity|IEA; GO:0006730|one-carbon compound metabolism|IEA; GO:0016787|hydrolase activity|IEA

ACL00000396

unclassified

ACL00000397

Similar to Dictyostelium discoideum (Slime mold). homeobox-containing protein related cluster

120

4e-06

46% (22/47)

GO:0003723|RNA binding|IEA; GO:0005634|nucleus|IEA

ACL00000398

Herpes_gp2 domain containing protein

111

5e-06

30% (39/127)

ACL00000399

Short chain dehydrogenase related cluster

217

2e-17

56% (44/78)

GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000400

Short chain dehydrogenase family protein related cluster

270

1e-23

48% (53/110)

GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000401

Nuclear transport factor 2 related cluster

344

8e-32

56% (69/123)

GO:0005622|intracellular|IEA; GO:0005634|nucleus|IEA; GO:0006606|protein-nucleus import|IEA; GO:0006810|transport|IEA; GO:0008565|protein transporter activity|IEA; GO:0015031|protein transport|IEA

ACL00000402

Unassigned protein

ACL00000404

unclassified

ACL00000405

Mito_carr domain containing protein

109

3e-06

34% (29/83)

ACL00000407

PHOX

Potential acid phosphatase related cluster

506

4e-50

40% (107/265)

3.1.3.2

GO:0003993|acid phosphatase activity|IEA; GO:0016787|hydrolase activity|IEA; GO:0016788|hydrolase activity, acting on ester bonds|IEA

ACL00000408

Herpes_gp2 domain containing protein

119

5e-07

26% (37/141)

ACL00000409

multi-domain protein

146

4e-10

50% (33/66)

ACL00000410

Golga7

Golga7; golgi autoantigen, golgin subfamily a, 7

235

2e-19

36% (39/106)

ACL00000411

AGR284Wp

AGR284Wp; syntenic homolog of Saccharomyces cerevisiae YLR285W

266

6e-23

40% (54/135)

ACL00000412

L8003.8 gene product

157

1e-10

40% (37/91)

ACL00000413

Putative requirement for the function of snoRNPs by similarity to human nop10, direct rRNA pseudouridinylation related cluster

242

2e-20

70% (45/64)

GO:0005634|nucleus|IEA; GO:0007046|ribosome biogenesis|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00000414

Beta-lactamase domain containing protein

114

1e-06

28% (23/81)

ACL00000415

D-alanyl-D-alanine carboxypeptidease, putative related cluster

137

4e-08

30% (30/98)

GO:0046677|response to antibiotic|IEA

ACL00000417

unclassified

ACL00000418

HSD17B12

Putative steroid dehydrogenase SPM2 related cluster

552

1e-55

44% (119/269)

1.1.1.-

General function prediction only

Ascorbate and aldarate metabolism Benzoate degradation via CoA ligation Bile acid biosynthesis Butanoate metabolism Fructose and mannose metabolism Galactose metabolism Glycerolipid metabolism Glycine, serine and threonine metabolism Lysine degradation Nucleotide sugars metabolism Tetrachloroethene degradation

GO:0006694|steroid biosynthesis|IEA; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000419

Unknown EST

116

6e-06

43% (22/51)

ACL00000420

unclassified

ACL00000421

rab2

Ras-related protein Rab-2A related cluster

743

7e-78

78% (139/177)

GO:0005525|GTP binding|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0005794|Golgi apparatus|IEA; GO:0006810|transport|IEA; GO:0006886|intracellular protein transport|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00000422

unclassified

ACL00000423

AER450Cp

Probable phosphate transport protein MIR1 related cluster

649

9e-67

48% (140/288)

GO:0005488|binding|IEA; GO:0005743|mitochondrial inner membrane|IEA; GO:0006810|transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA

ACL00000424

unclassified

ACL00000425

Putative 40S ribosomal protein S24 related cluster

468

7e-46

72% (86/118)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000426

kbl

2-amino-3-ketobutyrate CoA ligase related cluster

160

2e-36

70% (31/44)

2.3.1.29

Coenzyme transport and metabolism

Glycine, serine and threonine metabolism

GO:0003824|catalytic activity|IEA; GO:0003870|5-aminolevulinate synthase activity|IEA; GO:0006783|heme biosynthesis|IEA; GO:0008890|glycine C-acetyltransferase activity|IEA; GO:0009058|biosynthesis|IEA; GO:0016874|ligase activity|IEA

ACL00000427

Similar to glycine C-acetyltransferase related cluster

400

1e-38

52% (79/151)

GO:0003824|catalytic activity|IEA; GO:0003870|5-aminolevulinate synthase activity|IEA; GO:0006783|heme biosynthesis|IEA; GO:0008890|glycine C-acetyltransferase activity|IEA; GO:0009058|biosynthesis|IEA

ACL00000428

Ornithine aminotransferase related cluster

447

4e-43

60% (91/150)

Amino acid transport and metabolism

GO:0008483|transaminase activity|IEA; GO:0016740|transferase activity|IEA; GO:0030170|pyridoxal phosphate binding|IEA

ACL00000429

unclassified

ACL00000430

DUF355 domain containing protein

134

1e-09

54% (20/37)

ACL00000431

Unknown EST

143

3e-30

72% (27/37)

ACL00000432

Unknown EST

329

3e-35

84% (69/82)

ACL00000434

zgc:56227

Protein phosphatase 6 catalytic subunit related cluster

1356

1e-148

82% (247/299)

Signal transduction mechanisms

GO:0016787|hydrolase activity|IEA

ACL00000435

RRM domain containing protein

92

8e-06

32% (14/43)

ACL00000436

multi-domain protein

113

3e-06

21% (39/184)

ACL00000437

Putative heat shock protein related cluster

412

1e-39

54% (75/138)

GO:0006457|protein folding|IEA; GO:0006986|response to unfolded protein|IEA; GO:0051082|unfolded protein binding|IEA

ACL00000439

unclassified

ACL00000440

MYA6.7; metallo-beta-lactamase family protein

212

8e-17

56% (40/71)

General function prediction only

ACL00000441

unclassified

ACL00000442

Sec23b

Protein transport protein Sec23B related cluster

518

5e-52

64% (99/154)

GO:0005515|protein binding|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0005794|Golgi apparatus|IEA; GO:0006810|transport|IEA; GO:0006886|intracellular protein transport|IEA; GO:0006888|ER to Golgi transport|IEA; GO:0015031|protein transport|IEA; GO:0016020|membrane|TAS; GO:0016192|vesicle-mediated transport|TAS; GO:0030127|COPII vesicle coat|IEA

ACL00000443

(AL513464) probable SEC23 related cluster

637

2e-65

57% (132/228)

Intracellular trafficking, secretion, and vesicular transport

GO:0005515|protein binding|IEA; GO:0006886|intracellular protein transport|IEA; GO:0006888|ER to Golgi transport|IEA; GO:0030127|COPII vesicle coat|IEA

ACL00000444

VATC

Vacuolar ATP synthase subunit C related cluster

695

6e-72

39% (148/377)

3.6.3.14

Energy production and conversion

ATP synthesis Cholera - Infection Oxidative phosphorylation

GO:0005524|ATP binding|IEA; GO:0006754|ATP biosynthesis|IEA; GO:0015078|hydrogen ion transporter activity|IEA; GO:0015986|ATP synthesis coupled proton transport|IEA; GO:0015992|proton transport|IEA; GO:0016469|proton-transporting two-sector ATPase complex|IEA; GO:0016787|hydrolase activity|IEA; GO:0016820|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|IEA

ACL00000445

unclassified

ACL00000447

Rtn1

Reticulon 1 related cluster

173

8e-12

25% (55/219)

GO:0005554|molecular_function unknown|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0016021|integral to membrane|IEA

ACL00000448

unclassified

ACL00000449

unclassified

ACL00000450

unclassified

ACL00000451

DUF1421 domain containing protein

119

3e-07

27% (28/102)

ACL00000452

Unassigned protein

ACL00000453

unclassified

ACL00000454

UCRI

Ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial precursor related cluster

559

2e-56

55% (107/193)

1.10.2.2

GO:0005739|mitochondrion|IEA; GO:0005746|mitochondrial electron transport chain|IEA; GO:0006118|electron transport|IEA; GO:0008121|ubiquinol-cytochrome-c reductase activity|IEA; GO:0015008|ubiquinol-cytochrome-c reductase complex (sensu Eukaryota)|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0019866|inner membrane|IEA; GO:0045285|ubiquinol-cytochrome-c reductase complex|IEA

ACL00000455

Flavoprotein subunit of succinate dehydrogenase complex related cluster

487

9e-49

71% (86/120)

Energy production and conversion

GO:0006118|electron transport|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016627|oxidoreductase activity, acting on the CH-CH group of donors|IEA

ACL00000456

SdhA related cluster

718

5e-75

67% (138/205)

GO:0000104|succinate dehydrogenase activity|IEA; GO:0006118|electron transport|IEA; GO:0015036|disulfide oxidoreductase activity|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016627|oxidoreductase activity, acting on the CH-CH group of donors|IEA

ACL00000457

FAF protein related cluster

159

3e-10

25% (53/209)

ACL00000458

Appbp1

Amyloid protein-binding protein 1 related cluster

498

2e-49

40% (109/271)

Alzheimer's disease

GO:0003824|catalytic activity|IEA; GO:0005737|cytoplasm|TAS; GO:0006512|ubiquitin cycle|IEA; GO:0006915|apoptosis|IEA; GO:0007049|cell cycle|IEA; GO:0007165|signal transduction|TAS; GO:0016874|ligase activity|IEA

ACL00000459

unclassified

ACL00000460

ECE1

Endothelin-converting enzyme 1 related cluster

504

3e-50

48% (99/205)

3.4.24.71

GO:0004222|metalloendopeptidase activity|TAS; GO:0004245|neprilysin activity|IEA; GO:0005624|membrane fraction|TAS; GO:0006508|proteolysis and peptidolysis|IEA; GO:0007267|cell-cell signaling|NR; GO:0008237|metallopeptidase activity|IEA; GO:0008270|zinc ion binding|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016021|integral to membrane|TAS; GO:0016512|endothelin-converting enzyme 1 activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00000461

multi-domain protein

108

1e-05

24% (43/174)

ACL00000462

unclassified

ACL00000464

PP2Cc domain containing protein

122

1e-08

31% (21/66)

ACL00000465

PDP1

[Pyruvate dehydrogenase [Lipoamide]]-phosphatase 1, mitochondrial precursor related cluster

174

5e-12

30% (43/142)

3.1.3.43

Signal transduction mechanisms

GO:0000287|magnesium ion binding|IEA; GO:0003824|catalytic activity|IEA; GO:0004721|phosphoprotein phosphatase activity|IEA; GO:0004722|protein serine/threonine phosphatase activity|IEA; GO:0004741|[pyruvate dehydrogenase (lipoamide)] phosphatase activity|IEA; GO:0005509|calcium ion binding|IEA; GO:0005739|mitochondrion|IEA; GO:0006470|protein amino acid dephosphorylation|IEA; GO:0008287|protein serine/threonine phosphatase complex|IEA; GO:0016787|hydrolase activity|IEA

ACL00000466

unclassified

ACL00000469

unclassified

ACL00000470

cupin family protein

159

2e-10

34% (40/116)

ACL00000471

multi-domain protein

129

3e-08

25% (33/128)

ACL00000472

Nucleotide exchange factor RasGEF A related cluster

154

4e-10

28% (35/121)

GO:0005085|guanyl-nucleotide exchange factor activity|IEA; GO:0007242|intracellular signaling cascade|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00000473

Putative mitochondrial inner membrane protein related cluster

141

3e-08

30% (32/105)

GO:0005743|mitochondrial inner membrane|IEA; GO:0008565|protein transporter activity|IEA; GO:0015031|protein transport|IEA

ACL00000474

CBS domain containing protein

122

3e-07

36% (18/49)

ACL00000475

MIK19.20; GATA zinc finger protein

157

4e-10

52% (32/61)

ACL00000476

RAD23, isoform I related cluster

217

4e-17

35% (46/128)

GO:0005634|nucleus|IEA; GO:0006289|nucleotide-excision repair|IEA

ACL00000477

unclassified

ACL00000478

Countin related cluster

467

6e-46

46% (92/199)

ACL00000479

Similar to katanin p80 (WD40-containing) subunit B 1 related cluster

214

2e-16

30% (51/169)

General function prediction only

ACL00000483

DM6 domain containing protein

85

1e-04

27% (27/100)

ACL00000484

AFR390Cp

ORF YOR145C related cluster

669

2e-69

66% (132/199)

GO:0003676|nucleic acid binding|IEA; GO:0005634|nucleus|IDA; GO:0005730|nucleolus|IDA; GO:0006364|rRNA processing|IMP; GO:0006365|35S primary transcript processing|IMP; GO:0006461|protein complex assembly|IMP; GO:0051082|unfolded protein binding|IDA

ACL00000485

Unassigned protein

ACL00000486

multi-domain protein

125

1e-07

20% (33/165)

ACL00000488

Tubulin alpha-1B chain related cluster

1778

0.0

74% (325/434)

Cytoskeleton

GO:0003924|GTPase activity|IEA; GO:0005198|structural molecule activity|IEA; GO:0005525|GTP binding|IEA; GO:0005634|nucleus|IEA; GO:0005874|microtubule|IEA; GO:0007018|microtubule-based movement|IEA; GO:0045298|tubulin|IEA; GO:0046785|microtubule polymerization|IEA

ACL00000489

GTP-binding protein related cluster

559

1e-56

62% (109/174)

Translation, ribosomal structure and biogenesis

GO:0005525|GTP binding|IEA; GO:0005554|molecular_function unknown|IEA

ACL00000490

NBMPR-insensitive nucleoside transporter ei

133

2e-07

24% (38/157)

ACL00000491

DNCLI2

Dynein light intermediate chain 2, cytosolic related cluster

455

2e-44

34% (99/290)

GO:0003774|motor activity|IEA; GO:0005524|ATP binding|IEA; GO:0005868|cytoplasmic dynein complex|TAS; GO:0030286|dynein complex|IEA

ACL00000492

multi-domain protein

121

4e-07

22% (39/177)

ACL00000493

unclassified

ACL00000496

DUF614 domain containing protein

219

2e-18

25% (29/115)

ACL00000497

Kynurenine 3-monooxygenase related cluster

222

5e-18

43% (54/125)

1.14.13.9

Tryptophan metabolism

GO:0004497|monooxygenase activity|IEA; GO:0004502|kynurenine 3-monooxygenase activity|IEA; GO:0006725|aromatic compound metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000498

Kynurenine 3-monooxygenase related cluster

477

5e-47

45% (94/207)

1.14.13.9

Tryptophan metabolism

GO:0004497|monooxygenase activity|IEA; GO:0006118|electron transport|IEA; GO:0006725|aromatic compound metabolism|IEA; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000499

multi-domain protein

132

2e-08

25% (25/97)

ACL00000500

multi-domain protein

109

9e-06

21% (40/184)

ACL00000501

unclassified

ACL00000502

26S protease regulatory subunit 4 related cluster

491

7e-49

66% (92/139)

Posttranslational modification, protein turnover, chaperones

Proteasome

GO:0000502|proteasome complex (sensu Eukaryota)|TAS; GO:0016887|ATPase activity|TAS

ACL00000503

26S protease regulatory subunit 6A related cluster

1186

1e-129

61% (235/380)

Posttranslational modification, protein turnover, chaperones

GO:0000166|nucleotide binding|IEA; GO:0000502|proteasome complex (sensu Eukaryota)|TAS; GO:0003713|transcription coactivator activity|TAS; GO:0003714|transcription corepressor activity|TAS; GO:0005524|ATP binding|IEA; GO:0005634|nucleus|IEA; GO:0005634|nucleus|TAS; GO:0005737|cytoplasm|IEA; GO:0005829|cytosol|IEA; GO:0016787|hydrolase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA; GO:0030163|protein catabolism|IEA

ACL00000504

unclassified

ACL00000505

Tymo_45kd_70kd domain containing protein

114

3e-06

18% (43/236)

ACL00000506

Carboxypeptidase type III related cluster

158

1e-10

37% (41/108)

3.4.16.-

GO:0003824|catalytic activity|IEA; GO:0004180|carboxypeptidase activity|IEA; GO:0004185|serine carboxypeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA

ACL00000507

Peripheral-type benzodiazepine receptor related cluster

378

9e-36

51% (81/156)

Signal transduction mechanisms

GO:0004872|receptor activity|IEA; GO:0016021|integral to membrane|IEA

ACL00000508

unclassified

ACL00000509

Unknown EST

128

7e-08

31% (29/92)

ACL00000510

unclassified

ACL00000511

unclassified

ACL00000513

hemC

Porphobilinogen deaminase related cluster

792

1e-83

82% (156/190)

2.5.1.61

Coenzyme transport and metabolism

Porphyrin and chlorophyll metabolism

GO:0004418|hydroxymethylbilane synthase activity|IEA; GO:0006779|porphyrin biosynthesis|IEA; GO:0016740|transferase activity|IEA

ACL00000514

Hydroxyacylglutathione hydrolase related cluster

234

6e-19

30% (52/168)

GO:0004416|hydroxyacylglutathione hydrolase activity|IEA

ACL00000515

unclassified

ACL00000516

CBS domain protein related cluster

223

2e-17

26% (79/301)

General function prediction only

ACL00000517

unclassified

ACL00000518

Cd36

Cd36; CD36 antigen

128

1e-06

28% (33/116)

ACL00000519

multi-domain protein

125

1e-07

20% (36/176)

ACL00000521

unclassified

ACL00000522

Severin kinase related cluster

864

6e-92

83% (162/195)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0004713|protein-tyrosine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA

ACL00000523

multi-domain protein

126

1e-07

25% (42/167)

ACL00000524

unclassified

ACL00000525

GTP-binding protein SAS1 related cluster

110

1e-80

75% (22/29)

General function prediction only

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00000526

NDK

Nucleoside diphosphate kinase related cluster

153

6e-10

41% (33/80)

2.7.4.6

Nucleotide transport and metabolism

Purine metabolism Pyrimidine metabolism

GO:0000166|nucleotide binding|IEA; GO:0000287|magnesium ion binding|IEA; GO:0004550|nucleoside-diphosphate kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006183|GTP biosynthesis|IEA; GO:0006228|UTP biosynthesis|IEA; GO:0006241|CTP biosynthesis|IEA; GO:0009117|nucleotide metabolism|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00000531

unclassified

ACL00000532

fixL

Sensor protein fixL related cluster

239

2e-19

35% (50/141)

2.7.3.-

GO:0000155|two-component sensor molecule activity|IEA; GO:0000160|two-component signal transduction system (phosphorelay)|IEA; GO:0004871|signal transducer activity|IEA; GO:0005524|ATP binding|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0007165|signal transduction|IEA; GO:0007600|sensory perception|IEA; GO:0009399|nitrogen fixation|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016301|kinase activity|IEA; GO:0016310|phosphorylation|IEA; GO:0016740|transferase activity|IEA; GO:0016772|transferase activity, transferring phosphorus-containing groups|IEA; GO:0019866|inner membrane|IEA

ACL00000533

unclassified

ACL00000535

unclassified

ACL00000537

unclassified

ACL00000539

unclassified

ACL00000540

GYAR

Glyoxylate reductase related cluster

500

9e-50

50% (105/207)

1.1.1.26

GO:0006564|L-serine biosynthesis|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016616|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|IEA; GO:0047964|glyoxylate reductase activity|IEA

ACL00000541

PURA

Adenylosuccinate synthetase related cluster

339

1e-141

65% (56/85)

6.3.4.4

Nucleotide transport and metabolism

Alanine and aspartate metabolism Purine metabolism

GO:0000287|magnesium ion binding|IEA; GO:0004019|adenylosuccinate synthase activity|IEA; GO:0005525|GTP binding|IEA; GO:0006164|purine nucleotide biosynthesis|IEA; GO:0016874|ligase activity|IEA

ACL00000544

Unassigned protein

ACL00000545

AAR057Wp

Periodic tryptophan protein 2 related cluster

434

3e-42

44% (89/200)

GO:0000910|cytokinesis|IMP; GO:0005634|nucleus|IEA; GO:0005732|small nucleolar ribonucleoprotein complex|IPI; GO:0005737|cytoplasm|IDA; GO:0006364|rRNA processing|IEA; GO:0007046|ribosome biogenesis|IEA; GO:0030468|establishment of cell polarity (sensu Fungi)|IMP; GO:0030490|processing of 20S pre-rRNA|IMP; GO:0030515|snoRNA binding|IPI

ACL00000546

DM6 domain containing protein

86

1e-04

27% (27/100)

ACL00000547

unclassified

ACL00000548

Unassigned protein

ACL00000549

KPRS

Ribose-phosphate pyrophosphokinase related cluster

577

2e-58

52% (124/237)

2.7.6.1

Pentose phosphate pathway Purine metabolism

GO:0000287|magnesium ion binding|IEA; GO:0004749|ribose-phosphate diphosphokinase activity|IEA; GO:0009116|nucleoside metabolism|IEA; GO:0009156|ribonucleoside monophosphate biosynthesis|IEA; GO:0009165|nucleotide biosynthesis|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00000551

Calmodulin related cluster

194

3e-14

32% (46/141)

GO:0005509|calcium ion binding|IEA

ACL00000552

REN protein related cluster

264

7e-23

100% (52/52)

ACL00000554

Putative mRNA export protein related cluster

592

2e-60

58% (105/178)

ACL00000555

Deoxyribonuclease, TatD family related cluster

172

5e-12

30% (45/146)

ACL00000556

multi-domain protein

109

9e-07

47% (18/38)

ACL00000557

unclassified

ACL00000558

unclassified

ACL00000559

unclassified

ACL00000561

CGI-141

UPF0198 protein CGI-141 related cluster

314

3e-28

43% (59/137)

GO:0004871|signal transducer activity|IMP; GO:0016021|integral to membrane|IEA; GO:0016192|vesicle-mediated transport|IEA; GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB cascade|IMP

ACL00000563

unclassified

ACL00000564

unclassified

ACL00000565

JAB related cluster

1131

1e-122

73% (214/291)

General function prediction only

ACL00000566

DUF540 domain containing protein

117

7e-07

36% (22/60)

ACL00000567

unclassified

ACL00000568

multi-domain protein

114

2e-06

26% (23/88)

ACL00000569

Aquaporin related cluster

251

8e-21

34% (73/213)

GO:0005215|transporter activity|IEA; GO:0006810|transport|IEA; GO:0015288|porin activity|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0019867|outer membrane|IEA

ACL00000570

unclassified

ACL00000571

Putative snRNP protein related cluster

285

1e-24

61% (57/93)

Transcription

GO:0005634|nucleus|IEA; GO:0005654|nucleoplasm|IDA; GO:0005732|small nucleolar ribonucleoprotein complex|IEA; GO:0006397|mRNA processing|IEA; GO:0008248|pre-mRNA splicing factor activity|IEA; GO:0015030|Cajal body|IDA; GO:0030529|ribonucleoprotein complex|IEA

ACL00000572

FBOX domain containing protein

94

1e-05

30% (12/39)

ACL00000573

Ribosomal protein L10a related cluster

228

2e-18

34% (65/190)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000574

unclassified

ACL00000575

unclassified

ACL00000576

unclassified

ACL00000577

eef2l

Elongation factor 2 related cluster

749

1e-165

72% (139/192)

Translation, ribosomal structure and biogenesis

GO:0003746|translation elongation factor activity|IEA; GO:0003746|translation elongation factor activity|NR; GO:0005525|GTP binding|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006414|translational elongation|IEA

ACL00000579

POZ 56 protein homolog related cluster

130

2e-07

31% (33/104)

GO:0005515|protein binding|IEA

ACL00000580

Alkylated DNA repair protein related cluster

188

4e-14

37% (49/131)

Replication, recombination and repair

ACL00000581

Biotin synthetase, putative related cluster

220

9e-18

45% (51/112)

2.8.1.6

Biotin metabolism

GO:0003824|catalytic activity|IEA; GO:0005506|iron ion binding|IEA

ACL00000582

[O] COG5272 Ubiquitin

169

3e-12

48% (34/70)

Posttranslational modification, protein turnover, chaperones

ACL00000583

P-glycoprotein related cluster

329

4e-30

57% (64/111)

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0006810|transport|IEA; GO:0016021|integral to membrane|IEA; GO:0016887|ATPase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA; GO:0042626|ATPase activity, coupled to transmembrane movement of substances|IEA

ACL00000584

unclassified

ACL00000585

unclassified

ACL00000586

dld, RSc2664

Putative D-lactate dehydrogenase (Cytochrome) oxidoreductase protein related cluster

274

7e-24

48% (53/109)

1.1.2.4

Energy production and conversion

Pyruvate metabolism

GO:0004458|D-lactate dehydrogenase (cytochrome) activity|IEA; GO:0006118|electron transport|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000587

unclassified

ACL00000588

multi-domain protein

118

1e-06

23% (43/181)

ACL00000589

Maf1

Maf1; MAF1 homolog (yeast)

248

3e-21

45% (48/106)

ACL00000591

Putative membrane protein related cluster

290

2e-25

37% (63/170)

Function unknown

GO:0005554|molecular_function unknown|IEA; GO:0016020|membrane|IEA

ACL00000592

Ribosomal protein S4 related cluster

954

1e-102

67% (171/252)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003723|RNA binding|IEA; GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000593

SURE

Acid phosphatase surE related cluster

349

5e-32

31% (85/274)

3.1.3.2

General function prediction only

Riboflavin metabolism gamma-Hexachlorocyclohexane degradation

GO:0000287|magnesium ion binding|IEA; GO:0003993|acid phosphatase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00000594

F19G10.24; oxidoreductase, 2OG-Fe(II) oxygenase family protein

462

2e-45

54% (83/151)

ACL00000595

Similar to Homo sapiens (Human). high-risk human papilloma viruses E6 oncoproteins targeted protein E6TP1 alpha related cluster

179

5e-13

37% (38/102)

ACL00000598

ABCF2

Putative ABC transporter related cluster

145

3e-08

25% (54/212)

General function prediction only

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0016887|ATPase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

ACL00000600

unclassified

ACL00000601

unclassified

ACL00000602

unclassified

ACL00000604

unclassified

ACL00000605

Unassigned protein

ACL00000606

NADP-reducing hydrogenase, subunit D, putative related cluster

517

1e-51

45% (109/237)

1.6.5.3

General function prediction only

Oxidative phosphorylation Ubiquinone biosynthesis

GO:0005489|electron transporter activity|IEA; GO:0005506|iron ion binding|IEA; GO:0006118|electron transport|IEA; GO:0008901|ferredoxin hydrogenase activity|IEA

ACL00000607

unclassified

ACL00000608

multi-domain protein

115

2e-06

51% (25/49)

ACL00000610

Sc5d

Sc5d; sterol-C5-desaturase (fungal ERG3, delta-5-desaturase)-like

731

3e-76

51% (135/261)

Lipid transport and metabolism

ACL00000611

Sm-like protein related cluster

232

4e-19

54% (49/90)

Transcription

GO:0005634|nucleus|IEA; GO:0005732|small nucleolar ribonucleoprotein complex|IEA; GO:0006397|mRNA processing|IEA; GO:0008248|pre-mRNA splicing factor activity|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00000612

F18B13.17; CBS domain-containing protein

141

8e-08

21% (75/351)

General function prediction only

ACL00000613

ZRF1

Zuotin related factor-1 related cluster

142

2e-08

50% (27/54)

GO:0003677|DNA binding|IEA; GO:0005634|nucleus|IEA; GO:0005634|nucleus|NAS; GO:0006457|protein folding|IEA; GO:0006457|protein folding|NAS; GO:0051082|unfolded protein binding|IEA; GO:0051082|unfolded protein binding|NAS

ACL00000614

LYS1

Saccharopine dehydrogenase [NAD+, L-lysine forming] related cluster

377

2e-35

41% (93/225)

1.5.1.7

Lysine biosynthesis Lysine degradation

GO:0004754|saccharopine dehydrogenase (NAD+, L-lysine-forming) activity|IEA; GO:0006118|electron transport|IEA; GO:0009085|lysine biosynthesis|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000615

unclassified

ACL00000616

unclassified

ACL00000617

Exosome complex exonuclease RRP40 related cluster

443

3e-43

45% (90/200)

GO:0000178|exosome (RNase complex)|IEA; GO:0003723|RNA binding|IEA; GO:0004518|nuclease activity|IEA; GO:0004527|exonuclease activity|IEA; GO:0005634|nucleus|IEA; GO:0006364|rRNA processing|IEA; GO:0016787|hydrolase activity|IEA

ACL00000618

cysM

Cysteine synthase related cluster

299

2e-26

42% (62/146)

2.5.1.47

Amino acid transport and metabolism

Cysteine metabolism Selenoamino acid metabolism Sulfur metabolism

GO:0003824|catalytic activity|IEA; GO:0006535|cysteine biosynthesis from serine|IEA; GO:0008152|metabolism|IEA; GO:0008652|amino acid biosynthesis|IEA; GO:0016740|transferase activity|IEA; GO:0019344|cysteine biosynthesis|IEA

ACL00000620

Putative RING zinc finger protein related cluster

209

5e-16

29% (48/164)

GO:0000151|ubiquitin ligase complex|IEA; GO:0004842|ubiquitin-protein ligase activity|IEA; GO:0008270|zinc ion binding|IEA; GO:0016567|protein ubiquitination|IEA

ACL00000621

unclassified

ACL00000622

unclassified

ACL00000623

Trehalose-6-phosphate synthase homolog related cluster

215

8e-17

29% (51/175)

Carbohydrate transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0003825|alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity|IEA; GO:0004805|trehalose-phosphatase activity|IEA; GO:0005992|trehalose biosynthesis|IEA; GO:0008152|metabolism|IEA

ACL00000624

Sec61_beta domain containing protein

146

4e-10

45% (20/44)

ACL00000625

UPF0057 domain containing protein

186

6e-15

60% (30/50)

ACL00000626

UCR7

Probable ubiquinol-cytochrome C reductase complex 14 kDa protein related cluster

188

7e-14

43% (39/89)

1.10.2.2

Oxidative phosphorylation

GO:0005739|mitochondrion|IEA; GO:0005746|mitochondrial electron transport chain|IEA; GO:0006118|electron transport|IEA; GO:0006122|mitochondrial electron transport, ubiquinol to cytochrome c|IEA; GO:0008121|ubiquinol-cytochrome-c reductase activity|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0019866|inner membrane|IEA

ACL00000627

purH

IMP cyclohydrolase related cluster

576

2e-58

49% (130/263)

2.1.2.3 3.5.4.10

Nucleotide transport and metabolism

One carbon pool by folate Purine metabolism

GO:0003937|IMP cyclohydrolase activity|IEA; GO:0004643|phosphoribosylaminoimidazolecarboxamide formyltransferase activity|IEA; GO:0006164|purine nucleotide biosynthesis|IEA; GO:0016787|hydrolase activity|IEA

ACL00000629

Nodulin-like protein related cluster

225

8e-18

28% (59/207)

ACL00000630

Putative hydrolase related cluster

453

3e-44

43% (85/194)

General function prediction only

ACL00000632

wcaA

Possible glycosyl transferase related cluster

180

2e-12

37% (41/109)

Cell wall/membrane/envelope biogenesis

GO:0016740|transferase activity|IEA

ACL00000633

Ribosomal_L32p domain containing protein

133

1e-08

38% (20/52)

ACL00000634

Pyrrolidone carboxyl peptidase-like protein related cluster

298

2e-26

37% (76/202)

Posttranslational modification, protein turnover, chaperones

GO:0004219|pyroglutamyl-peptidase I activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA

ACL00000635

Initiation factor 3g related cluster

394

3e-37

38% (110/286)

GO:0003676|nucleic acid binding|IEA; GO:0003723|RNA binding|IEA; GO:0003743|translation initiation factor activity|IEA

ACL00000636

unclassified

ACL00000637

unclassified

ACL00000638

Transposase related cluster

260

1e-21

31% (75/239)

Replication, recombination and repair

ACL00000640

unclassified

ACL00000641

Diphosphonucleotide phosphatase-like protein related cluster

464

1e-45

40% (94/231)

GO:0016787|hydrolase activity|IEA

ACL00000642

spi1

GTP-binding nuclear protein spi1 related cluster

737

3e-77

77% (139/180)

General function prediction only

GO:0005525|GTP binding|IEA; GO:0005634|nucleus|IEA; GO:0006886|intracellular protein transport|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00000643

unclassified

ACL00000644

unclassified

ACL00000645

ACBP/ECHM related cluster

194

9e-15

53% (35/65)

GO:0000062|acyl-CoA binding|IEA; GO:0003824|catalytic activity|IEA; GO:0008152|metabolism|IEA

ACL00000646

multi-domain protein

115

3e-06

20% (56/272)

ACL00000647

F27H5.50; phagocytosis and cell motility protein ELMO1-related

268

8e-23

29% (69/237)

ACL00000648

Phospholipid scramblase 1 related cluster

119

1e-05

28% (42/149)

GO:0005509|calcium ion binding|IEA; GO:0016021|integral to membrane|IEA

ACL00000649

zgc:55762

Similar to serologically defined breast cancer antigen 84 related cluster

1005

1e-108

60% (189/312)

ACL00000650

Putative plant adhesion molecule related cluster

295

2e-26

41% (55/131)

ACL00000651

CG8472

Calmodulin related cluster

411

1e-39

53% (78/147)

Phosphatidylinositol signaling system

GO:0005509|calcium ion binding|IEA

ACL00000654

multi-domain protein

115

2e-06

21% (28/130)

ACL00000655

Unassigned protein

209

3e-16

41% (41/100)

ACL00000656

unclassified

ACL00000657

ARPC2

ARP2/3 complex 34 kDa subunit related cluster

595

1e-60

45% (124/274)

Regulation of actin cytoskeleton

GO:0005200|structural constituent of cytoskeleton|TAS; GO:0005856|cytoskeleton|IEA; GO:0005885|Arp2/3 protein complex|TAS; GO:0006928|cell motility|TAS; GO:0015629|actin cytoskeleton|TAS; GO:0030833|regulation of actin filament polymerization|IEA

ACL00000658

unclassified

ACL00000659

unclassified

ACL00000661

MutT/nudix family protein related cluster

396

1e-37

43% (82/188)

GO:0016787|hydrolase activity|IEA

ACL00000662

Herpes_gp2 domain containing protein

111

6e-06

22% (28/123)

ACL00000663

hcP-1

hcP-1; prismane protein

918

5e-98

60% (173/287)

Energy production and conversion

ACL00000664

multi-domain protein

109

9e-06

20% (35/172)

ACL00000665

Ribosomal protein L18 related cluster

152

1e-50

49% (30/61)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000666

Possible ribosomal L21-like protein related cluster

164

9e-11

64% (34/53)

Translation, ribosomal structure and biogenesis

GO:0003723|RNA binding|IEA; GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000667

Serpin 4 related cluster

313

5e-28

34% (75/219)

GO:0004866|endopeptidase inhibitor activity|IEA; GO:0004867|serine-type endopeptidase inhibitor activity|IEA

ACL00000668

TPIS

Triosephosphate isomerase, cytosolic related cluster

732

2e-76

61% (147/239)

5.3.1.1

Carbohydrate transport and metabolism

Carbon fixation Fructose and mannose metabolism Glycerolipid metabolism Glycolysis / Gluconeogenesis Inositol metabolism

GO:0004807|triose-phosphate isomerase activity|IEA; GO:0006094|gluconeogenesis|IEA; GO:0006096|glycolysis|IEA; GO:0006098|pentose-phosphate shunt|IEA; GO:0006633|fatty acid biosynthesis|IEA; GO:0008152|metabolism|IEA; GO:0016853|isomerase activity|IEA

ACL00000669

Similar to Dictyostelium discoideum (Slime mold). myosin I heavy chain kinase related cluster

468

4e-46

72% (88/122)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA

ACL00000670

CG9277

Tubulin beta-1 chain related cluster

1137

1e-123

80% (213/266)

Cytoskeleton

GO:0003924|GTPase activity|IEA; GO:0005198|structural molecule activity|IEA; GO:0005525|GTP binding|IEA; GO:0005634|nucleus|IEA; GO:0005874|microtubule|IEA; GO:0007018|microtubule-based movement|IEA; GO:0045298|tubulin|IEA; GO:0046785|microtubule polymerization|IEA

ACL00000671

FAS1 domain containing protein

86

1e-04

30% (25/83)

ACL00000672

Herpes_gp2 domain containing protein

111

5e-06

21% (46/210)

ACL00000673

Heat shock protein Ddj1 related cluster

371

9e-35

43% (83/190)

GO:0006457|protein folding|IEA; GO:0006986|response to unfolded protein|IEA; GO:0051082|unfolded protein binding|IEA

ACL00000674

SLC25A11

Mitochondrial 2-oxoglutarate/malate carrier protein related cluster

743

8e-78

56% (145/255)

GO:0005215|transporter activity|IEA; GO:0005488|binding|IEA; GO:0005739|mitochondrion|IEA; GO:0005743|mitochondrial inner membrane|IEA; GO:0005743|mitochondrial inner membrane|TAS; GO:0005887|integral to plasma membrane|TAS; GO:0006810|transport|IEA; GO:0006810|transport|TAS; GO:0015367|oxoglutarate:malate antiporter activity|TAS; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0019866|inner membrane|IEA

ACL00000675

Unassigned protein

ACL00000676

CG13852

CG13852; CG13852 gene product

704

2e-73

62% (127/203)

ACL00000677

TNKS2

Tankyrase 2 related cluster

185

2e-13

42% (47/110)

2.4.2.30

GO:0000781|chromosome, telomeric region|IEA; GO:0003950|NAD+ ADP-ribosyltransferase activity|IEA; GO:0005634|nucleus|IEA; GO:0005794|Golgi apparatus|IEA; GO:0007004|telomerase-dependent telomere maintenance|IEA; GO:0016740|transferase activity|IEA; GO:0016757|transferase activity, transferring glycosyl groups|IEA

ACL00000678

HBXIP

Hepatitis B virus X interacting protein related cluster

120

4e-06

28% (25/89)

GO:0009615|response to virus|TAS; GO:0019079|viral genome replication|TAS

ACL00000679

Stard10

Stard10; START domain containing 10

142

3e-08

26% (44/165)

ACL00000680

Ppp2ca

Protein phosphatase 2A catalytic subunit related cluster

1447

1e-159

85% (258/301)

3.1.3.16

Signal transduction mechanisms

TGF-beta signaling pathway Wnt signaling pathway

GO:0016787|hydrolase activity|IEA

ACL00000681

Unassigned protein

ACL00000682

FBOX domain containing protein

90

5e-05

35% (12/34)

ACL00000683

Oligosaccharyl transferase STT3 subunit homolog related cluster

975

1e-104

68% (182/264)

GO:0004576|oligosaccharyl transferase activity|IEA; GO:0005624|membrane fraction|TAS; GO:0005887|integral to plasma membrane|TAS; GO:0006486|protein amino acid glycosylation|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA

ACL00000684

Protein kinase related cluster

128

3e-06

24% (48/196)

GO:0016301|kinase activity|IEA

ACL00000685

unclassified

ACL00000686

Commd4

Commd4; COMM domain containing 4

409

3e-39

44% (89/201)

ACL00000688

multi-domain protein

140

3e-09

22% (53/237)

ACL00000689

multi-domain protein

121

4e-07

24% (36/148)

ACL00000690

multi-domain protein

117

1e-06

20% (36/172)

ACL00000692

HSC20

Co-chaperone protein HscB, mitochondrial precursor related cluster

324

2e-29

34% (67/194)

Posttranslational modification, protein turnover, chaperones

GO:0005739|mitochondrion|IEA; GO:0006457|protein folding|IEA; GO:0051082|unfolded protein binding|IEA; GO:0051087|chaperone binding|IEA

ACL00000693

unclassified

ACL00000694

putative permease

157

4e-10

37% (40/107)

ACL00000695

Inosine-uridine preferring nucleoside hydrolase related cluster

187

4e-13

27% (56/207)

Nucleotide transport and metabolism

Nicotinate and nicotinamide metabolism Purine metabolism

GO:0005975|carbohydrate metabolism|IEA; GO:0008477|purine nucleosidase activity|IEA; GO:0016787|hydrolase activity|IEA; GO:0016798|hydrolase activity, acting on glycosyl bonds|IEA

ACL00000696

FBL

Fibrillarin related cluster

994

1e-106

77% (184/236)

Translation, ribosomal structure and biogenesis

GO:0003723|RNA binding|IEA; GO:0005634|nucleus|IEA; GO:0006364|rRNA processing|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00000697

PPT1

Palmitoyl-protein thioesterase 1 precursor related cluster

472

9e-47

51% (91/176)

3.1.2.22

GO:0003824|catalytic activity|IEA; GO:0005764|lysosome|IEA; GO:0006464|protein modification|IEA; GO:0008474|palmitoyl-(protein) hydrolase activity|IEA; GO:0016787|hydrolase activity|IEA; GO:0048167|regulation of synaptic plasticity|TAS

ACL00000698

multi-domain protein

127

1e-07

21% (47/218)

ACL00000699

t_SNARE domain containing protein

109

4e-07

25% (17/68)

ACL00000703

Putative FtsH protease related cluster

503

4e-50

56% (103/182)

Posttranslational modification, protein turnover, chaperones

GO:0000166|nucleotide binding|IEA; GO:0000910|cytokinesis|IEA; GO:0004176|ATP-dependent peptidase activity|IEA; GO:0004222|metalloendopeptidase activity|IEA; GO:0004252|serine-type endopeptidase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0016020|membrane|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA; GO:0030163|protein catabolism|IEA

ACL00000704

aroQ

3-dehydroquinate dehydratase, type II related cluster

154

4e-10

41% (37/89)

4.2.1.10

Amino acid transport and metabolism

Phenylalanine, tyrosine and tryptophan biosynthesis

GO:0003855|3-dehydroquinate dehydratase activity|IEA; GO:0009073|aromatic amino acid family biosynthesis|IEA

ACL00000705

MTMR3

Similar to myotubularin related protein 3 related cluster

184

2e-13

30% (39/127)

3.1.3.48

GO:0008270|zinc ion binding|IEA

ACL00000707

AGL250Wp

Nucleolar protein Nop4 related cluster

145

4e-09

48% (36/75)

GO:0003723|RNA binding|IEA

ACL00000708

Copz1

Coatomer zeta-1 subunit related cluster

245

3e-20

34% (62/182)

Posttranslational modification, protein turnover, chaperones

ACL00000709

Similar to Oryza sativa (Rice). 36I5.3 related cluster

169

7e-12

41% (42/101)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA

ACL00000710

unclassified

ACL00000714

unclassified

ACL00000717

YbaK/EbsC protein

289

1e-25

50% (59/117)

ACL00000718

PFC0975c, CPR3

Cyclophilin 1 related cluster

103

2e-47

47% (21/44)

5.2.1.8

Posttranslational modification, protein turnover, chaperones

GO:0003755|peptidyl-prolyl cis-trans isomerase activity|IEA; GO:0006457|protein folding|IEA; GO:0016853|isomerase activity|IEA

ACL00000720

Ras-related protein Rap-1 related cluster

731

2e-76

85% (143/167)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00000724

unclassified

ACL00000725

Phospholipid hydroperoxide glutathione peroxidase B related cluster

451

1e-43

54% (84/155)

Posttranslational modification, protein turnover, chaperones

GO:0004601|peroxidase activity|IEA; GO:0004602|glutathione peroxidase activity|IEA; GO:0006979|response to oxidative stress|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0047066|phospholipid-hydroperoxide glutathione peroxidase activity|IEA

ACL00000726

CYP7

Peptidyl-prolyl cis-trans isomerase 7 related cluster

537

5e-54

68% (98/144)

5.2.1.8

Posttranslational modification, protein turnover, chaperones

GO:0003755|peptidyl-prolyl cis-trans isomerase activity|IEA; GO:0006457|protein folding|IEA; GO:0016853|isomerase activity|IEA

ACL00000727

Nonspecific lipid-transfer protein, mitochondrial precursor related cluster

197

1e-14

50% (41/81)

GO:0005498|sterol carrier activity|IEA; GO:0005498|sterol carrier activity|TAS; GO:0005739|mitochondrion|IEA; GO:0005777|peroxisome|IEA; GO:0005777|peroxisome|TAS; GO:0006694|steroid biosynthesis|TAS; GO:0006810|transport|IEA; GO:0006869|lipid transport|IEA; GO:0008289|lipid binding|IEA

ACL00000728

unclassified

ACL00000729

Arhgap7

Rho-GTPase-activating protein 7 related cluster

142

3e-08

30% (49/159)

GO:0005096|GTPase activator activity|IEA; GO:0005100|Rho GTPase activator activity|NAS; GO:0005515|protein binding|NAS; GO:0005737|cytoplasm|NAS; GO:0007010|cytoskeleton organization and biogenesis|NAS; GO:0030155|regulation of cell adhesion|NAS; GO:0030308|negative regulation of cell growth|IDA

ACL00000732

Putative mitochondrial processing peptidase related cluster

330

2e-30

45% (68/150)

General function prediction only

GO:0004222|metalloendopeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA

ACL00000733

MRC8.21; oxidoreductase, 2OG-Fe(II) oxygenase family protein

358

4e-33

32% (81/253)

ACL00000734

unclassified

ACL00000735

ECHM

Enoyl-CoA hydratase, mitochondrial precursor related cluster

812

1e-85

62% (159/255)

4.2.1.17

Lipid transport and metabolism

Benzoate degradation via CoA ligation Butanoate metabolism Fatty acid biosynthesis (path 2) Fatty acid metabolism Limonene and pinene degradation Lysine degradation Propanoate metabolism Tryptophan metabolism Valine, leucine and isoleucine degradation beta-Alanine metabolism

GO:0003824|catalytic activity|IEA; GO:0004300|enoyl-CoA hydratase activity|IEA; GO:0005739|mitochondrion|IEA; GO:0006631|fatty acid metabolism|IEA; GO:0008152|metabolism|IEA; GO:0016829|lyase activity|IEA

ACL00000736

CBS domain protein related cluster

185

8e-13

23% (70/301)

General function prediction only

ACL00000739

Rehydrin related cluster

753

4e-79

64% (137/212)

ACL00000741

Putative RNA helicase related cluster

698

7e-73

87% (129/147)

GO:0003676|nucleic acid binding|IEA; GO:0004386|helicase activity|IEA; GO:0005524|ATP binding|IEA; GO:0008026|ATP-dependent helicase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00000742

60S ribosomal protein L10 related cluster

797

4e-84

75% (145/193)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000746

DM6 domain containing protein

94

2e-05

36% (24/66)

ACL00000748

unclassified

ACL00000750

Probable ATP-dependent RNA helicase HAS1 related cluster

707

6e-74

69% (127/182)

GO:0003676|nucleic acid binding|IEA; GO:0003723|RNA binding|IEA; GO:0004386|helicase activity|IEA; GO:0005524|ATP binding|IEA; GO:0005634|nucleus|IEA; GO:0005635|nuclear membrane|IDA; GO:0005730|nucleolus|IDA; GO:0006364|rRNA processing|IEA; GO:0006364|rRNA processing|IMP; GO:0007046|ribosome biogenesis|IEA; GO:0008026|ATP-dependent helicase activity|IEA

ACL00000751

MOBKL1A

MOBKL1A; MOB1, Mps One Binder kinase activator-like 1A (yeast)

337

2e-31

75% (60/80)

ACL00000752

Unassigned protein

ACL00000753

p450 domain containing protein

121

4e-07

25% (26/104)

ACL00000754

UMP1 domain containing protein

214

5e-18

33% (38/114)

ACL00000755

CCT chaperonin theta subunit related cluster

62

2e-34

54% (12/22)

Posttranslational modification, protein turnover, chaperones

GO:0005524|ATP binding|IEA; GO:0006457|protein folding|IEA; GO:0051082|unfolded protein binding|IEA

ACL00000756

unclassified

ACL00000757

Eukaryotic peptide chain release factor subunit 1 related cluster

640

5e-66

71% (113/157)

Translation, ribosomal structure and biogenesis

GO:0005737|cytoplasm|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006415|translational termination|IEA; GO:0006415|translational termination|IMP; GO:0016149|translation release factor activity, codon specific|IEA; GO:0035071|salivary gland cell death|IEP; GO:0048102|autophagic cell death|IEP

ACL00000758

unclassified

ACL00000760

Immunophilin FK506 binding protein FKBP12 related cluster

327

6e-30

54% (58/106)

GO:0006457|protein folding|IEA

ACL00000761

SODF

Superoxide dismutase [Fe] related cluster

434

6e-42

44% (86/194)

1.15.1.1

Inorganic ion transport and metabolism

GO:0004784|superoxide dismutase activity|IEA; GO:0006801|superoxide metabolism|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0046872|metal ion binding|IEA

ACL00000762

[P] COG3221 ABC-type phosphate/phosphonate transport system, periplasmic component

172

2e-12

44% (40/89)

Inorganic ion transport and metabolism

ACL00000764

unclassified

ACL00000765

60S ribosomal protein L17 related cluster

464

6e-46

75% (89/118)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0015934|large ribosomal subunit|IEA

ACL00000767

Cytochrome c1 related cluster

759

2e-79

59% (138/233)

Energy production and conversion

Oxidative phosphorylation

GO:0005489|electron transporter activity|IEA; GO:0005739|mitochondrion|IEA; GO:0005746|mitochondrial electron transport chain|IEA; GO:0006118|electron transport|IEA; GO:0008121|ubiquinol-cytochrome-c reductase activity|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000768

Glutaredoxin-related protein related cluster

278

5e-24

48% (48/98)

Posttranslational modification, protein turnover, chaperones

GO:0005489|electron transporter activity|IEA; GO:0006118|electron transport|IEA

ACL00000769

Unknown EST

55

4e-06

52% (13/25)

ACL00000771

unclassified

ACL00000772

Fatty acid synthetase beta-subunit related cluster

203

8e-16

61% (35/57)

GO:0004312|fatty-acid synthase activity|IEA; GO:0005835|fatty-acid synthase complex|IEA; GO:0006633|fatty acid biosynthesis|IEA; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016740|transferase activity|IEA

ACL00000773

Unassigned protein

90

4e-09

42% (21/49)

ACL00000774

unclassified

ACL00000775

bioB

Biotin synthase and related enzymes related cluster

79

6e-27

53% (16/30)

2.8.1.6

Biotin metabolism

GO:0003824|catalytic activity|IEA; GO:0005506|iron ion binding|IEA

ACL00000776

dapE

dapE; succinyl-diaminopimelate desuccinylase

404

5e-39

50% (77/151)

ACL00000777

Peroxidase ppod2 related cluster

161

6e-10

33% (40/118)

GO:0004601|peroxidase activity|IEA

ACL00000778

unclassified

ACL00000779

NIFU-like protein related cluster

157

3e-44

76% (29/38)

Energy production and conversion

ACL00000780

unclassified

ACL00000781

Putative flavonol synthase-like protein related cluster

220

1e-17

46% (50/108)

General function prediction only

GO:0005506|iron ion binding|IEA; GO:0016216|isopenicillin-N synthase activity|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0017000|antibiotic biosynthesis|IEA

ACL00000782

IGF2R

Mannose-6-phosphate/insulin-like growth factor II receptor related cluster

130

1e-06

33% (48/143)

GO:0004872|receptor activity|IEA; GO:0005215|transporter activity|IEA; GO:0005764|lysosome|IEA; GO:0006810|transport|IEA; GO:0016020|membrane|IEA

ACL00000784

5-aminolevulinic acid dehydratase related cluster

154

2e-50

65% (32/49)

4.2.1.24

Coenzyme transport and metabolism

Porphyrin and chlorophyll metabolism

GO:0004655|porphobilinogen synthase activity|IEA; GO:0006779|porphyrin biosynthesis|IEA; GO:0006783|heme biosynthesis|IEA; GO:0016829|lyase activity|IEA

ACL00000785

Putative UDP-glucose 4-epimerase related cluster

134

2e-07

28% (53/184)

ACL00000787

unclassified

ACL00000788

Putative enoyl-CoA hydratase protein related cluster

463

2e-45

42% (100/233)

4.2.1.17

Lipid transport and metabolism

Benzoate degradation via CoA ligation Butanoate metabolism Fatty acid biosynthesis (path 2) Fatty acid metabolism Limonene and pinene degradation Lysine degradation Propanoate metabolism Tryptophan metabolism Valine, leucine and isoleucine degradation beta-Alanine metabolism

GO:0003824|catalytic activity|IEA; GO:0004300|enoyl-CoA hydratase activity|IEA; GO:0008152|metabolism|IEA; GO:0016829|lyase activity|IEA

ACL00000790

Indolepyruvate decarboxylase, putative related cluster

423

6e-41

44% (89/199)

ACL00000791

40S ribosomal protein S26 related cluster

303

2e-27

74% (55/74)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000792

Ribosomal protein L7AE-like related cluster

441

5e-43

72% (89/123)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000793

Spopl1

POZ 56 protein homolog related cluster

126

7e-07

31% (31/99)

GO:0005515|protein binding|IEA

ACL00000802

Actin bundling protein related cluster

925

8e-99

67% (188/277)

ACL00000805

P2C1

Protein phosphatase 2C homolog 1 related cluster

534

2e-53

42% (111/261)

3.1.3.16

Signal transduction mechanisms

GO:0000001|mitochondrion inheritance|IMP; GO:0000173|inactivation of MAPK during osmolarity sensing|IDA; GO:0000287|magnesium ion binding|IEA; GO:0003824|catalytic activity|IEA; GO:0004721|phosphoprotein phosphatase activity|IEA; GO:0004722|protein serine/threonine phosphatase activity|IEA; GO:0005634|nucleus|IDA; GO:0005737|cytoplasm|IDA; GO:0006388|tRNA splicing|IMP; GO:0006457|protein folding|IEA; GO:0006470|protein amino acid dephosphorylation|IDA; GO:0006470|protein amino acid dephosphorylation|IEA; GO:0006986|response to unfolded protein|IEA; GO:0008287|protein serine/threonine phosphatase complex|IEA; GO:0015071|protein phosphatase type 2C activity|IDA; GO:0016787|hydrolase activity|IEA; GO:0030145|manganese ion binding|IEA

ACL00000812

unclassified

ACL00000813

Nucleolar protein C7C related cluster

271

2e-23

41% (57/136)

ACL00000814

PSA3

Proteasome subunit alpha type 3 related cluster

166

2e-11

91% (33/36)

3.4.25.1

Posttranslational modification, protein turnover, chaperones

Proteasome

GO:0004175|endopeptidase activity|IEA; GO:0005829|cytosol|IEA; GO:0005839|proteasome core complex (sensu Eukaryota)|IEA; GO:0006511|ubiquitin-dependent protein catabolism|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00000815

Delta-12 oleate desaturase related cluster

193

1e-14

60% (38/63)

1.14.99.-

Lipid transport and metabolism

1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) degradation Androgen and estrogen metabolism Benzoate degradation via hydroxylation Nicotinate and nicotinamide metabolism

GO:0006633|fatty acid biosynthesis|IEA; GO:0006636|fatty acid desaturation|IEA; GO:0008610|lipid biosynthesis|IEA; GO:0016020|membrane|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016717|oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water|IEA; GO:0050184|phosphatidylcholine desaturase activity|IEA

ACL00000816

ATPD

ATP synthase delta chain, mitochondrial precursor related cluster

251

3e-21

40% (63/154)

3.6.3.14

Energy production and conversion

ATP synthesis Oxidative phosphorylation Photosynthesis

GO:0005739|mitochondrion|IEA; GO:0006754|ATP biosynthesis|IEA; GO:0015078|hydrogen ion transporter activity|IEA; GO:0015986|ATP synthesis coupled proton transport|IEA; GO:0015992|proton transport|IEA; GO:0016469|proton-transporting two-sector ATPase complex|IEA; GO:0016787|hydrolase activity|IEA; GO:0046933|hydrogen-transporting ATP synthase activity, rotational mechanism|IEA; GO:0046961|hydrogen-transporting ATPase activity, rotational mechanism|IEA

ACL00000817

Cell division-like protein related cluster

173

2e-12

85% (34/40)

2.1.1.-

GO:0000910|cytokinesis|IEA

ACL00000819

unclassified

ACL00000821

unclassified

ACL00000822

unclassified

ACL00000823

Translationally controlled tumor protein homolog related cluster

307

2e-27

42% (70/164)

GO:0005554|molecular_function unknown|IEA; GO:0005737|cytoplasm|IEA; GO:0006457|protein folding|IEA; GO:0051082|unfolded protein binding|IEA

ACL00000824

KCY

Cytidylate kinase related cluster

637

1e-65

63% (120/188)

2.7.4.14

Nucleotide transport and metabolism

GO:0004127|cytidylate kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006221|pyrimidine nucleotide biosynthesis|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA; GO:0016776|phosphotransferase activity, phosphate group as acceptor|IEA

ACL00000825

Myosin I heavy chain kinase related cluster

340

1e-31

98% (64/65)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00000826

unclassified

ACL00000827

F-actin capping protein alpha subunit related cluster

850

3e-90

56% (154/274)

GO:0003779|actin binding|IEA; GO:0008290|F-actin capping protein complex|IEA; GO:0030036|actin cytoskeleton organization and biogenesis|IEA

ACL00000828

PSB2

Proteasome subunit beta type 2 related cluster

303

2e-27

59% (58/97)

3.4.25.1

Posttranslational modification, protein turnover, chaperones

Proteasome

GO:0004175|endopeptidase activity|IEA; GO:0005829|cytosol|IEA; GO:0005839|proteasome core complex (sensu Eukaryota)|IEA; GO:0006511|ubiquitin-dependent protein catabolism|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00000829

40S ribosomal protein S5-2 related cluster

304

6e-81

79% (57/72)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0015935|small ribosomal subunit|IEA

ACL00000830

Usp domain containing protein

223

5e-19

32% (49/152)

ACL00000831

unclassified

ACL00000832

Ras-like GTP-binding protein YPT1 related cluster

512

4e-51

50% (101/201)

General function prediction only

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00000833

unclassified

ACL00000834

unclassified

ACL00000835

TIEG2

Transforming growth factor-beta-inducible early growth response protein 2 related cluster

134

8e-08

59% (22/37)

GO:0000122|negative regulation of transcription from Pol II promoter|TAS; GO:0003676|nucleic acid binding|IEA; GO:0003677|DNA binding|IEA; GO:0003700|transcription factor activity|TAS; GO:0005634|nucleus|IEA; GO:0005634|nucleus|TAS; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006366|transcription from Pol II promoter|TAS; GO:0008270|zinc ion binding|IEA; GO:0008285|negative regulation of cell proliferation|TAS

ACL00000836

Putative sterol 4-alpha-methyl-oxidase related cluster

141

1e-08

51% (33/64)

1.-.-.-

Lipid transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0008152|metabolism|IEA

ACL00000837

Putative acyl-CoA transferases/carnitine dehydratase related cluster

151

9e-10

34% (31/90)

Energy production and conversion

GO:0008152|metabolism|IEA; GO:0016740|transferase activity|IEA

ACL00000838

60S ribosomal protein L39 related cluster

235

2e-19

85% (42/49)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000840

unclassified

ACL00000842

mgll

mgll; monoglyceride lipase

90

3e-11

52% (18/34)

Lipid transport and metabolism

ACL00000843

unclassified

ACL00000844

unclassified

ACL00000846

unclassified

ACL00000851

SSU rRNA; A.castellanii mature small subunit rRNA gene, complete.

467

0.0

100% (467/467)

ACL00000853

Galactosidase, putative related cluster

136

9e-08

38% (32/84)

GO:0004565|beta-galactosidase activity|IEA; GO:0005529|sugar binding|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0009341|beta-galactosidase complex|IEA

ACL00000854

Putative heat shock protein related cluster

557

2e-56

57% (104/180)

GO:0006457|protein folding|IEA; GO:0006986|response to unfolded protein|IEA; GO:0051082|unfolded protein binding|IEA

ACL00000855

unclassified

ACL00000856

DUF1077 domain containing protein

299

8e-28

37% (62/167)

ACL00000857

TGF-beta receptor-interacting protein 1 related cluster

746

5e-78

48% (140/291)

GO:0004872|receptor activity|IEA

ACL00000858

unclassified

ACL00000859

unclassified

ACL00000860

Probable acetyl-CoA acetyltransferase related cluster

405

3e-39

65% (75/115)

2.3.1.9

Lipid transport and metabolism

Benzoate degradation via CoA ligation Butanoate metabolism Fatty acid biosynthesis (path 2) Fatty acid metabolism Lysine degradation Propanoate metabolism Pyruvate metabolism Synthesis and degradation of ketone bodies Tryptophan metabolism Valine, leucine and isoleucine degradation

GO:0003985|acetyl-CoA C-acetyltransferase activity|IEA; GO:0008415|acyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00000861

unclassified

ACL00000862

ODO2

Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor related cluster

76

4e-33

50% (13/26)

2.3.1.61

Energy production and conversion

Citrate cycle (TCA cycle) Lysine degradation

GO:0004149|dihydrolipoyllysine-residue succinyltransferase activity|IEA; GO:0005739|mitochondrion|IEA; GO:0006091|generation of precursor metabolites and energy|TAS; GO:0006099|tricarboxylic acid cycle|IEA; GO:0008152|metabolism|IEA; GO:0008415|acyltransferase activity|IEA; GO:0016740|transferase activity|IEA; GO:0045252|oxoglutarate dehydrogenase complex|IEA

ACL00000863

unclassified

ACL00000864

Phosphoglycolate phosphatase precursor related cluster

122

2e-06

45% (31/68)

gamma-Hexachlorocyclohexane degradation

GO:0003824|catalytic activity|IEA; GO:0008152|metabolism|IEA; GO:0016787|hydrolase activity|IEA; GO:0016791|phosphoric monoester hydrolase activity|IEA

ACL00000866

unclassified

ACL00000867

unclassified

ACL00000868

unclassified

ACL00000869

unclassified

ACL00000871

Putative urease accessory protein D related cluster

195

2e-14

30% (56/183)

GO:0006807|nitrogen compound metabolism|IEA; GO:0016151|nickel ion binding|IEA

ACL00000872

UB2EC

Ubiquitin-conjugating enzyme X related cluster

420

1e-40

64% (77/120)

6.3.2.19

Posttranslational modification, protein turnover, chaperones

GO:0000910|cytokinesis|IEA; GO:0004840|ubiquitin conjugating enzyme activity|IEA; GO:0004842|ubiquitin-protein ligase activity|IEA; GO:0006464|protein modification|IEA; GO:0006512|ubiquitin cycle|IEA; GO:0007049|cell cycle|IEA; GO:0007067|mitosis|IEA; GO:0016874|ligase activity|IEA

ACL00000873

unclassified

ACL00000874

unclassified

ACL00000875

UBA domain containing protein

91

3e-05

47% (17/36)

ACL00000876

Unassigned protein

ACL00000877

WD-repeat protein An11 homolog related cluster

419

7e-41

67% (76/113)

General function prediction only

GO:0005737|cytoplasm|NR; GO:0007165|signal transduction|TAS

ACL00000878

unclassified

ACL00000879

Herpes_gp2 domain containing protein

115

2e-06

19% (37/192)

ACL00000880

unclassified

ACL00000881

unclassified

ACL00000882

Putative golgi membrane protein related cluster

123

5e-06

22% (44/192)

Intracellular trafficking, secretion, and vesicular transport

ACL00000883

unclassified

ACL00000885

unclassified

ACL00000887

unclassified

ACL00000888

DUF393 domain containing protein

121

3e-07

29% (23/79)

ACL00000889

unclassified

ACL00000890

Putative alcohol dehydrogenase related cluster

644

3e-66

45% (134/293)

ACL00000891

unclassified

ACL00000892

Unassigned protein

123

4e-06

29% (33/113)

ACL00000893

Putative rac GTPase activating protein related cluster

169

7e-12

34% (37/106)

ACL00000895

unclassified

ACL00000896

unclassified

ACL00000897

unclassified

ACL00000898

Unassigned protein

190

3e-14

57% (39/68)

ACL00000899

unclassified

ACL00000901

hspC

Small heat shock protein related cluster

199

1e-14

38% (35/91)

Posttranslational modification, protein turnover, chaperones

GO:0006457|protein folding|IEA; GO:0006986|response to unfolded protein|IEA

ACL00000902

t_SNARE domain containing protein

94

2e-05

25% (17/68)

ACL00000903

Transcription factor APFI related cluster

487

3e-48

46% (97/210)

ACL00000904

unclassified

ACL00000905

unclassified

ACL00000906

Unassigned protein

144

8e-09

29% (41/139)

ACL00000907

IPK domain containing protein

114

4e-07

39% (19/48)

ACL00000908

unclassified

ACL00000909

unclassified

ACL00000910

TT_ORF1 domain containing protein

114

2e-06

30% (26/85)

ACL00000912

unclassified

ACL00000913

unclassified

ACL00000914

Molybdopterin biosynthesis CNX1 protein related cluster

299

6e-27

52% (65/125)

Coenzyme transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0006777|Mo-molybdopterin cofactor biosynthesis|IEA

ACL00000915

guaB

IMP dehydrogenase related cluster

267

3e-23

70% (51/72)

1.1.1.205

Nucleotide transport and metabolism

Purine metabolism

GO:0003824|catalytic activity|IEA; GO:0003938|IMP dehydrogenase activity|IEA; GO:0006164|purine nucleotide biosynthesis|IEA; GO:0006177|GMP biosynthesis|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000916

unclassified

ACL00000917

COG6

COG6; component of oligomeric golgi complex 6

321

3e-29

34% (65/187)

ACL00000918

G protein beta subunit-like protein related cluster

180

1e-12

26% (53/203)

ACL00000919

TT_ORF1 domain containing protein

117

6e-07

42% (25/59)

ACL00000920

unclassified

ACL00000922

DHRSX

Retinol dehydrogenase 12 related cluster

368

3e-34

36% (91/251)

GO:0004745|retinol dehydrogenase activity|ISS; GO:0005615|extracellular space|TAS; GO:0005622|intracellular|ISS; GO:0007601|visual perception|IEA; GO:0007601|visual perception|ISS; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0042572|retinol metabolism|ISS; GO:0045494|photoreceptor maintenance|ISS

ACL00000923

unclassified

ACL00000924

unclassified

ACL00000925

lat

Probable L-lysine-epsilon aminotransferase related cluster

128

4e-07

62% (22/35)

2.6.1.36

Amino acid transport and metabolism

Lysine biosynthesis

ACL00000928

multi-domain protein

124

2e-07

21% (55/255)

ACL00000929

Machado-Joseph disease protein 1 related cluster

305

1e-27

41% (53/127)

GO:0005634|nucleus|IEA; GO:0005654|nucleoplasm|TAS; GO:0005737|cytoplasm|TAS; GO:0006289|nucleotide-excision repair|TAS; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0007268|synaptic transmission|TAS; GO:0007399|neurogenesis|TAS

ACL00000930

unclassified

ACL00000932

unclassified

ACL00000933

unclassified

ACL00000934

Protamine_P1 domain containing protein

112

3e-06

42% (24/57)

ACL00000935

unclassified

ACL00000936

FPPS

Farnesyl pyrophosphate synthetase related cluster

130

2e-07

61% (21/34)

2.5.1.1

Coenzyme transport and metabolism

GO:0004337|geranyltranstransferase activity|IEA; GO:0006695|cholesterol biosynthesis|IEA; GO:0008299|isoprenoid biosynthesis|IEA; GO:0016740|transferase activity|IEA

ACL00000937

unclassified

ACL00000940

Unknown EST

57

6e-06

37% (11/29)

ACL00000941

Ndufa5

NADH-ubiquinone oxidoreductase related cluster

246

3e-20

51% (49/95)

1.6.5.3 1.6.99.3

Oxidative phosphorylation

GO:0005743|mitochondrial inner membrane|IEA; GO:0006118|electron transport|IEA; GO:0016651|oxidoreductase activity, acting on NADH or NADPH|IEA

ACL00000942

PSB3

Proteasome subunit beta type 3 related cluster

670

2e-69

61% (126/205)

3.4.25.1

Posttranslational modification, protein turnover, chaperones

Proteasome

GO:0004175|endopeptidase activity|IEA; GO:0005829|cytosol|IEA; GO:0005839|proteasome core complex (sensu Eukaryota)|IEA; GO:0006511|ubiquitin-dependent protein catabolism|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00000944

unclassified

ACL00000945

Unassigned protein

ACL00000946

Unknown EST

111

6e-06

48% (19/39)

ACL00000947

PSA7

Proteasome subunit alpha type 7 related cluster

714

1e-74

71% (140/195)

3.4.25.1

Posttranslational modification, protein turnover, chaperones

Proteasome

GO:0004175|endopeptidase activity|IEA; GO:0005829|cytosol|IEA; GO:0005839|proteasome core complex (sensu Eukaryota)|IEA; GO:0006511|ubiquitin-dependent protein catabolism|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00000948

[R] COG0790 FOG: TPR repeat, SEL1 subfamily

191

7e-15

36% (46/127)

General function prediction only

ACL00000949

unclassified

ACL00000950

unclassified

ACL00000951

TLP19

Similar to thioredoxin-like protein p19 related cluster

325

1e-29

50% (64/126)

GO:0005489|electron transporter activity|IEA; GO:0006118|electron transport|IEA

ACL00000953

Unknown EST

125

6e-07

32% (21/65)

ACL00000955

TT_ORF1 domain containing protein

110

8e-06

44% (27/61)

ACL00000956

unclassified

ACL00000957

START domain containing protein

133

1e-08

20% (41/199)

ACL00000958

Eif4el3

Eukaryotic translation initiation factor 4E type 3 related cluster

230

1e-18

51% (45/87)

Translation, ribosomal structure and biogenesis

GO:0000339|RNA cap binding|TAS; GO:0003723|RNA binding|IEA; GO:0003743|translation initiation factor activity|IEA; GO:0005737|cytoplasm|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006413|translational initiation|IEA; GO:0006417|regulation of protein biosynthesis|IEA; GO:0006445|regulation of translation|IEA; GO:0006445|regulation of translation|TAS; GO:0008135|translation factor activity, nucleic acid binding|TAS

ACL00000959

unclassified

ACL00000960

RAPB protein related cluster

217

7e-17

53% (41/76)

GO:0003700|transcription factor activity|IEA; GO:0005634|nucleus|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA

ACL00000961

unclassified

ACL00000962

Pept_tRNA_hydro domain containing protein

118

7e-07

24% (33/133)

ACL00000963

Nonhistone chromosomal protein related cluster

219

2e-17

55% (37/67)

GO:0000785|chromatin|IEA; GO:0003677|DNA binding|IEA; GO:0005634|nucleus|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA

ACL00000966

multi-domain protein

132

3e-08

45% (22/48)

ACL00000967

unclassified

ACL00000968

Mago nashi-like protein related cluster

649

3e-67

81% (117/143)

ACL00000969

Glutathione S-transferase related cluster

572

3e-58

61% (112/183)

Posttranslational modification, protein turnover, chaperones

GO:0004364|glutathione transferase activity|IEA

ACL00000970

unclassified

ACL00000972

Putative 32.7 kDa rhodanese-like thiosulfate sulfurtransferase related cluster

282

4e-24

30% (82/269)

2.8.1.1

Inorganic ion transport and metabolism

GO:0004792|thiosulfate sulfurtransferase activity|IEA; GO:0008272|sulfate transport|IEA; GO:0016740|transferase activity|IEA

ACL00000973

F5O11.2; stress-inducible protein, putative

135

5e-08

73% (25/34)

ACL00000974

multi-domain protein

120

5e-07

26% (51/193)

ACL00000975

TT_ORF1 domain containing protein

111

5e-06

41% (34/82)

ACL00000976

multi-domain protein

174

5e-13

21% (74/352)

ACL00000977

S-adenosylmethionine-dependent methyltransferase, putative related cluster

526

8e-53

48% (109/226)

GO:0008168|methyltransferase activity|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00000978

DnaJ homolog subfamily B member 11 precursor related cluster

207

3e-16

44% (41/93)

Posttranslational modification, protein turnover, chaperones

GO:0005783|endoplasmic reticulum|IEA; GO:0006457|protein folding|IEA; GO:0051082|unfolded protein binding|IEA

ACL00000979

unclassified

ACL00000983

AL1A3

Aldehyde dehydrogenase 6 related cluster

552

7e-56

51% (101/197)

1.2.1.5

Energy production and conversion

GO:0004028|aldehyde dehydrogenase activity|TAS; GO:0004030|aldehyde dehydrogenase [NAD(P)+] activity|IEA; GO:0006066|alcohol metabolism|TAS; GO:0006629|lipid metabolism|TAS; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00000984

unclassified

ACL00000985

CwfJ_C_1 domain containing protein

225

2e-19

31% (28/88)

ACL00000986

unclassified

ACL00000987

multi-domain protein

117

8e-07

42% (30/70)

ACL00000988

ACLY

ATP-citrate synthase related cluster

1063

1e-115

68% (191/278)

2.3.3.8

Energy production and conversion

Citrate cycle (TCA cycle)

GO:0000287|magnesium ion binding|IEA; GO:0003824|catalytic activity|IEA; GO:0003878|ATP citrate synthase activity|IEA; GO:0003878|ATP citrate synthase activity|TAS; GO:0005524|ATP binding|IEA; GO:0006101|citrate metabolism|TAS; GO:0006200|ATP catabolism|TAS; GO:0008152|metabolism|IEA; GO:0008610|lipid biosynthesis|IEA; GO:0009346|citrate lyase complex|TAS; GO:0015936|coenzyme A metabolism|TAS; GO:0016740|transferase activity|IEA

ACL00000990

unclassified

ACL00000992

unclassified

ACL00000993

WD-repeat protein related cluster

152

5e-16

43% (31/71)

GO:0006952|defense response|IEA; GO:0042829|defense response to pathogen|IEA

ACL00000994

Mrpl12

60S ribosomal protein L7/L12 related cluster

171

2e-11

28% (40/141)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00000996

Transitional endoplasmic reticulum ATPase homolog 1 related cluster

327

3e-30

62% (74/118)

Posttranslational modification, protein turnover, chaperones

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0008151||IEA; GO:0016787|hydrolase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

ACL00000997

unclassified

ACL00000998

PSA5

Proteasome subunit alpha type 5 related cluster

708

5e-74

72% (145/201)

3.4.25.1

Posttranslational modification, protein turnover, chaperones

Proteasome

GO:0000502|proteasome complex (sensu Eukaryota)|TAS; GO:0004175|endopeptidase activity|IEA; GO:0005829|cytosol|IEA; GO:0005839|proteasome core complex (sensu Eukaryota)|IEA; GO:0006511|ubiquitin-dependent protein catabolism|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00000999

unclassified

ACL00001000

G10 protein homolog related cluster

613

6e-63

72% (102/141)

GO:0003700|transcription factor activity|TAS; GO:0005554|molecular_function unknown|IEA; GO:0005634|nucleus|IEA; GO:0005634|nucleus|TAS; GO:0006357|regulation of transcription from Pol II promoter|TAS

ACL00001001

unclassified

ACL00001002

Putative eukaryotic initiation factor subunit related cluster

505

4e-50

47% (108/227)

GO:0003723|RNA binding|IEA; GO:0003743|translation initiation factor activity|IEA; GO:0006413|translational initiation|IEA

ACL00001003

unclassified

ACL00001004

DHB4

Peroxisomal multifunctional enzyme type 2 related cluster

436

2e-42

46% (90/194)

1.1.1.35

GO:0003824|catalytic activity|IEA; GO:0003857|3-hydroxyacyl-CoA dehydrogenase activity|IEA; GO:0004303|estradiol 17-beta-dehydrogenase activity|TAS; GO:0005498|sterol carrier activity|IEA; GO:0005498|sterol carrier activity|TAS; GO:0005777|peroxisome|IEA; GO:0005777|peroxisome|TAS; GO:0006631|fatty acid metabolism|IEA; GO:0008152|metabolism|IEA; GO:0015248|sterol transporter activity|TAS; GO:0016491|oxidoreductase activity|IEA; GO:0016829|lyase activity|IEA; GO:0016853|isomerase activity|IEA

ACL00001005

Beta-glucosidase related cluster

389

3e-37

49% (83/169)

Carbohydrate transport and metabolism

GO:0004553|hydrolase activity, hydrolyzing O-glycosyl compounds|IEA; GO:0005975|carbohydrate metabolism|IEA

ACL00001006

Unassigned protein

ACL00001007

unclassified

ACL00001008

Similar to Homo sapiens (Human). MAD2-like protein 1 related cluster

638

3e-65

65% (120/184)

ACL00001009

unclassified

ACL00001010

GCST

Aminomethyltransferase, mitochondrial precursor related cluster

124

1e-06

53% (32/60)

2.1.2.10

Amino acid transport and metabolism

GO:0004047|aminomethyltransferase activity|IEA; GO:0005739|mitochondrion|IEA; GO:0006546|glycine catabolism|IEA; GO:0008483|transaminase activity|IEA; GO:0016740|transferase activity|IEA

ACL00001011

MIL23.11; transducin family protein / WD-40 repeat family protein

365

2e-34

53% (67/125)

General function prediction only

ACL00001012

multi-domain protein

107

7e-06

27% (20/72)

ACL00001013

unclassified

ACL00001015

Putative involvement in cytochrome oxidase assembly related cluster

143

7e-09

47% (30/63)

ACL00001016

p150 target of rapamycin (TOR)-scaffold protein

367

2e-34

40% (81/200)

ACL00001017

unclassified

ACL00001018

Putative pre-mRNA splicing factor related cluster

172

9e-12

27% (60/219)

GO:0005488|binding|IEA; GO:0005622|intracellular|IEA; GO:0006396|RNA processing|IEA

ACL00001019

Phosphorylase kinase alpha subunit related cluster

234

6e-19

47% (58/121)

GO:0005516|calmodulin binding|IEA; GO:0005977|glycogen metabolism|IEA; GO:0016301|kinase activity|IEA

ACL00001020

unclassified

ACL00001022

Molybdenum cofactor biosynthesis protein Cnx1 related cluster

370

7e-35

45% (78/170)

Coenzyme transport and metabolism

GO:0006777|Mo-molybdopterin cofactor biosynthesis|IEA

ACL00001023

Kinesin-like protein related cluster

119

4e-06

51% (18/35)

GO:0000151|ubiquitin ligase complex|IEA; GO:0003774|motor activity|IEA; GO:0004842|ubiquitin-protein ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0005875|microtubule associated complex|IEA; GO:0008270|zinc ion binding|IEA; GO:0016567|protein ubiquitination|IEA

ACL00001024

Replication factor C large subunit-like protein related cluster

159

1e-10

35% (37/105)

Replication, recombination and repair

GO:0000166|nucleotide binding|IEA; GO:0003677|DNA binding|IEA; GO:0005524|ATP binding|IEA; GO:0005622|intracellular|IEA; GO:0005663|DNA replication factor C complex|IEA; GO:0006260|DNA replication|IEA; GO:0006952|defense response|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA; GO:0042829|defense response to pathogen|IEA

ACL00001025

DNA repair protein Rad51 homolog related cluster

75

2e-35

76% (13/17)

GO:0000166|nucleotide binding|IEA; GO:0003677|DNA binding|IEA; GO:0003684|damaged DNA binding|IEA; GO:0005524|ATP binding|IEA; GO:0005622|intracellular|IEA; GO:0006281|DNA repair|IEA; GO:0006310|DNA recombination|IEA; GO:0008094|DNA-dependent ATPase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

ACL00001026

unclassified

ACL00001027

GCH1

GTP cyclohydrolase I related cluster

169

3e-65

64% (31/48)

3.5.4.16

Coenzyme transport and metabolism

Folate biosynthesis

GO:0003824|catalytic activity|IEA; GO:0003934|GTP cyclohydrolase I activity|IEA; GO:0006729|tetrahydrobiopterin biosynthesis|IEA; GO:0009058|biosynthesis|IEA; GO:0016787|hydrolase activity|IEA

ACL00001028

PLDP1

Phospholipase D p1 related cluster

415

9e-40

40% (103/253)

3.1.4.4

GO:0003824|catalytic activity|IEA; GO:0004630|phospholipase D activity|IEA; GO:0008152|metabolism|IEA; GO:0016042|lipid catabolism|IEA; GO:0016787|hydrolase activity|IEA

ACL00001029

PIN1

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 related cluster

405

6e-39

54% (83/153)

5.2.1.8

Posttranslational modification, protein turnover, chaperones

GO:0003755|peptidyl-prolyl cis-trans isomerase activity|IEA; GO:0005515|protein binding|TAS; GO:0005634|nucleus|IEA; GO:0005634|nucleus|TAS; GO:0006457|protein folding|IEA; GO:0007049|cell cycle|IEA; GO:0007088|regulation of mitosis|TAS; GO:0016853|isomerase activity|IEA

ACL00001030

Csrp2

Cysteine and glycine-rich protein 2 related cluster

185

2e-13

46% (29/63)

GO:0005554|molecular_function unknown|ND; GO:0005634|nucleus|IEA; GO:0005634|nucleus|NAS; GO:0007275|development|IEA; GO:0007517|muscle development|NAS; GO:0008270|zinc ion binding|IEA; GO:0008283|cell proliferation|NAS; GO:0009887|organogenesis|NAS; GO:0016049|cell growth|NAS; GO:0030154|cell differentiation|IEA; GO:0030154|cell differentiation|NAS

ACL00001031

unclassified

ACL00001032

PABPC1

Similar to poly(A)-binding protein 1 related cluster

144

6e-09

66% (30/45)

ACL00001033

Purple acid phosphatase-like protein related cluster

212

2e-16

36% (56/152)

GO:0016787|hydrolase activity|IEA

ACL00001034

HIPPO

Serine/threonine-protein kinase hippo related cluster

489

2e-48

50% (96/192)

2.7.1.37

GO:0000122|negative regulation of transcription from Pol II promoter|NAS; GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IDA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|NAS; GO:0005515|protein binding|IEA; GO:0005515|protein binding|NAS; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IDA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0006468|protein amino acid phosphorylation|NAS; GO:0006915|apoptosis|IEA; GO:0006915|apoptosis|IMP; GO:0007165|signal transduction|IEA; GO:0008283|cell proliferation|IMP; GO:0008372|cellular_component unknown|ND; GO:0016740|transferase activity|IEA; GO:0042127|regulation of cell proliferation|TAS; GO:0043065|positive regulation of apoptosis|TAS; GO:0045926|negative regulation of growth|TAS

ACL00001035

Ribosomal protein S16 related cluster

389

6e-37

81% (71/87)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00001036

Arpc4

ARP2/3 complex 20 kDa subunit related cluster

671

2e-69

74% (125/167)

Regulation of actin cytoskeleton

GO:0005856|cytoskeleton|IEA; GO:0030041|actin filament polymerization|IEA

ACL00001037

Putative amino acid transport protein related cluster

182

6e-13

27% (48/174)

Amino acid transport and metabolism

ACL00001038

PGMP

Phosphoglucomutase, chloroplast precursor related cluster

83

4e-13

65% (17/26)

5.4.2.2

Carbohydrate transport and metabolism

Galactose metabolism Glycolysis / Gluconeogenesis Pentose phosphate pathway Starch and sucrose metabolism Streptomycin biosynthesis

GO:0000287|magnesium ion binding|IEA; GO:0004614|phosphoglucomutase activity|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0009507|chloroplast|IEA; GO:0016853|isomerase activity|IEA; GO:0016868|intramolecular transferase activity, phosphotransferases|IEA

ACL00001039

ADP-ribosylation factor 3 related cluster

352

5e-33

53% (80/150)

GO:0005525|GTP binding|IEA; GO:0005794|Golgi apparatus|IEA; GO:0006886|intracellular protein transport|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00001040

multi-domain protein

135

1e-08

26% (60/225)

ACL00001041

PPB

Repressible alkaline phosphatase precursor related cluster

163

2e-10

55% (37/67)

3.1.3.1

Inorganic ion transport and metabolism

Folate biosynthesis Glycerolipid metabolism gamma-Hexachlorocyclohexane degradation

GO:0000287|magnesium ion binding|IEA; GO:0000329|vacuolar membrane (sensu Fungi)|IDA; GO:0004035|alkaline phosphatase activity|IDA; GO:0004035|alkaline phosphatase activity|IEA; GO:0006470|protein amino acid dephosphorylation|IDA; GO:0008152|metabolism|IEA; GO:0016021|integral to membrane|IEA; GO:0016576|histone dephosphorylation|IDA; GO:0016787|hydrolase activity|IEA

ACL00001042

Ribosomal protein L17 related cluster

265

9e-23

53% (53/100)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00001043

Similar to Xenopus laevis (African clawed frog). calcium/calmodulin-dependent protein kinase I alpha related cluster

752

1e-78

50% (158/311)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00001044

Unassigned protein

ACL00001045

Putative oxidoreductase related cluster

286

2e-25

51% (56/108)

GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00001046

unclassified

ACL00001047

Zinc transporter protein ZIP1 related cluster

270

7e-23

29% (90/309)

GO:0005385|zinc ion transporter activity|IEA; GO:0006829|zinc ion transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0030001|metal ion transport|IEA; GO:0046873|metal ion transporter activity|IEA

ACL00001048

GCDH

Glutaryl-CoA dehydrogenase, mitochondrial precursor related cluster

694

3e-72

68% (132/194)

1.3.99.7

Lipid transport and metabolism

Benzoate degradation via CoA ligation Fatty acid metabolism Lysine degradation Tryptophan metabolism

GO:0003995|acyl-CoA dehydrogenase activity|IEA; GO:0004361|glutaryl-CoA dehydrogenase activity|IEA; GO:0005739|mitochondrion|IEA; GO:0006118|electron transport|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00001050

unclassified

ACL00001051

Probable single-stranded DNA-binding protein 68k chain related cluster

261

2e-22

38% (53/139)

Replication, recombination and repair

GO:0003676|nucleic acid binding|IEA; GO:0003677|DNA binding|IEA; GO:0005634|nucleus|IEA; GO:0006260|DNA replication|IEA

ACL00001052

unclassified

ACL00001053

unclassified

ACL00001054

unclassified

ACL00001055

amino acid/polyamine transporter, family II (54.0 kD) (XL883) [Caenorhabditis elegans] emb|CAA97776.2| Hypothetical protein C03A3.2 [Caenorhabditis elegans]

219

5e-17

31% (55/175)

ACL00001056

GTP-binding protein related cluster

454

1e-44

56% (99/175)

Translation, ribosomal structure and biogenesis

GO:0005525|GTP binding|IEA; GO:0005554|molecular_function unknown|IEA

ACL00001057

Bap31 domain containing protein

209

2e-17

25% (50/200)

ACL00001058

unclassified

ACL00001059

yecM

Putative cytoplasmic protein related cluster

134

2e-07

31% (49/157)

ACL00001061

Putative dehydrogenase related cluster

616

5e-63

52% (133/255)

GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00001062

Adenylyl cyclase-associated protein related cluster

471

2e-46

57% (88/154)

GO:0003779|actin binding|IEA; GO:0016020|membrane|IEA

ACL00001064

unclassified

ACL00001065

Putative CMF receptor CMFR1 related cluster

384

2e-36

48% (70/143)

GO:0004497|monooxygenase activity|IEA; GO:0004872|receptor activity|IEA; GO:0006118|electron transport|IEA; GO:0006725|aromatic compound metabolism|IEA; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00001068

Putative phosphotransferase related cluster

80

1e-27

50% (15/30)

Translation, ribosomal structure and biogenesis

GO:0006388|tRNA splicing|IEA; GO:0016772|transferase activity, transferring phosphorus-containing groups|IEA

ACL00001070

6-phosphogluconate dehydrogenase, decarboxylating related cluster

1417

1e-155

59% (265/447)

1.1.1.44

Carbohydrate transport and metabolism

Pentose phosphate pathway

GO:0004616|phosphogluconate dehydrogenase (decarboxylating) activity|IEA; GO:0006098|pentose-phosphate shunt|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00001071

Gtpbp4

Probable nucleolar GTP-binding protein 1 related cluster

276

3e-24

76% (51/67)

General function prediction only

GO:0005525|GTP binding|IEA; GO:0005634|nucleus|IEA; GO:0007046|ribosome biogenesis|IEA

ACL00001072

unclassified

ACL00001073

unclassified

ACL00001074

Alpha-centractin related cluster

1205

1e-131

65% (232/352)

GO:0003774|motor activity|IEA; GO:0005198|structural molecule activity|IEA; GO:0005200|structural constituent of cytoskeleton|IEA; GO:0005856|cytoskeleton|IEA; GO:0005884|actin filament|IEA; GO:0015629|actin cytoskeleton|IEA

ACL00001075

unclassified

ACL00001076

multi-domain protein

127

1e-07

21% (56/257)

ACL00001077

unclassified

ACL00001079

T-complex protein 1, alpha subunit related cluster

401

1e-115

63% (80/126)

GO:0005524|ATP binding|IEA; GO:0005753|proton-transporting ATP synthase complex (sensu Eukaryota)|NAS; GO:0006457|protein folding|IEA; GO:0008553|hydrogen-exporting ATPase activity, phosphorylative mechanism|NAS; GO:0051082|unfolded protein binding|IEA

ACL00001080

unclassified

ACL00001081

unclassified

ACL00001082

Glutaredoxin-like protein related cluster

110

5e-22

53% (17/32)

Posttranslational modification, protein turnover, chaperones

GO:0005489|electron transporter activity|IEA; GO:0006118|electron transport|IEA

ACL00001083

Lysozyme II precursor related cluster

304

5e-27

38% (71/183)

ACL00001084

Chloroplast 50S ribosomal protein L22, putative, 25606-24374 related cluster

177

4e-12

31% (52/165)

Translation, ribosomal structure and biogenesis

GO:0003723|RNA binding|IEA; GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0015934|large ribosomal subunit|IEA; GO:0019843|rRNA binding|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00001085

Unassigned protein

ACL00001086

Cab39

Cab39; calcium binding protein 39

534

1e-53

46% (105/225)

ACL00001087

multi-domain protein

133

8e-11

45% (15/33)

ACL00001088

unclassified

ACL00001089

putative vesicular transport and membrane fusion protein

Vesicular-fusion protein SEC18 homolog related cluster

272

2e-23

36% (58/158)

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0005794|Golgi apparatus|IEA; GO:0006810|transport|IEA; GO:0015031|protein transport|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

ACL00001092

CCT chaperonin alpha subunit related cluster

413

8e-40

58% (90/153)

Posttranslational modification, protein turnover, chaperones

GO:0005524|ATP binding|IEA; GO:0006457|protein folding|IEA; GO:0051082|unfolded protein binding|IEA

ACL00001093

PI3_PI4_kinase domain containing protein

117

8e-07

22% (29/127)

ACL00001094

unclassified

ACL00001095

unclassified

ACL00001097

unclassified

ACL00001098

Methlytransferase, UbiE/COQ5 family related cluster

230

3e-18

25% (61/241)

GO:0008168|methyltransferase activity|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA

ACL00001099

GDI domain containing protein

102

4e-06

77% (17/22)

ACL00001100

DNCI1

Dynein intermediate chain 1, cytosolic related cluster

131

2e-07

60% (23/38)

GO:0003774|motor activity|IEA; GO:0003774|motor activity|TAS; GO:0005868|cytoplasmic dynein complex|TAS; GO:0030286|dynein complex|IEA

ACL00001101

unclassified

ACL00001102

unclassified

ACL00001103

unclassified

ACL00001104

unclassified

ACL00001106

ATP-synt domain containing protein

114

2e-06

30% (23/75)

ACL00001107

unclassified

ACL00001108

Indole-3-pyruvate decarboxylase related cluster

222

9e-18

37% (57/154)

4.1.1.1

Tryptophan metabolism

GO:0016829|lyase activity|IEA; GO:0047434|indolepyruvate decarboxylase activity|IEA

ACL00001109

unclassified

ACL00001110

arpc1a

Similar to actin related protein 2/3 complex, subunit 1B related cluster

608

4e-62

46% (120/257)

ACL00001111

CG5649

Drosophila melanogaster KIN17 protein related cluster

324

7e-30

61% (56/91)

ACL00001112

39s ribosomal protein L47, mitochondrial precursor related cluster

179

1e-12

41% (41/100)

GO:0003735|structural constituent of ribosome|IEA; GO:0005739|mitochondrion|IEA

ACL00001113

unclassified

ACL00001114

Unknown EST

363

9e-41

81% (76/93)

ACL00001115

unclassified

ACL00001116

unclassified

ACL00001117

Phosphoprotein phosphatase A related cluster

97

8e-39

51% (17/33)

GO:0005488|binding|IEA

ACL00001118

Adhfe1

Alcohol dehydrogenase 8 related cluster

184

1e-13

59% (32/54)

Energy production and conversion

GO:0005506|iron ion binding|IEA; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00001119

Zinc finger protein HRX related cluster

73

1e-06

50% (13/26)

GO:0003677|DNA binding|IEA; GO:0003700|transcription factor activity|NAS; GO:0003702|RNA polymerase II transcription factor activity|TAS; GO:0005634|nucleus|IEA; GO:0005634|nucleus|TAS; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006366|transcription from Pol II promoter|TAS; GO:0008151||IEA; GO:0008270|zinc ion binding|IEA

ACL00001120

Cytosolic aldolase related cluster

238

1e-103

61% (46/75)

Carbohydrate transport and metabolism

GO:0004332|fructose-bisphosphate aldolase activity|IEA; GO:0006096|glycolysis|IEA; GO:0016829|lyase activity|IEA

ACL00001121

26S proteasome regulatory subunit S2 related cluster

340

1e-31

68% (67/98)

Posttranslational modification, protein turnover, chaperones

Proteasome

GO:0000074|regulation of cell cycle|IEA; GO:0005488|binding|IEA; GO:0005829|cytosol|IEA

ACL00001122

26S proteasome non-ATPase regulatory subunit 10 related cluster

214

4e-17

36% (50/136)

GO:0000502|proteasome complex (sensu Eukaryota)|TAS; GO:0005829|cytosol|IEA; GO:0005838|proteasome regulatory particle (sensu Eukaryota)|TAS

ACL00001123

Napa

Beta-soluble NSF attachment protein related cluster

678

3e-70

47% (136/287)

GO:0005478|intracellular transporter activity|IEA; GO:0005488|binding|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0005794|Golgi apparatus|IEA; GO:0006810|transport|IEA; GO:0006886|intracellular protein transport|IEA; GO:0015031|protein transport|IEA

ACL00001124

Unknown EST

125

2e-08

58% (21/36)

ACL00001125

GTP1

Glutathione S-transferase P 1 related cluster

235

4e-19

35% (67/191)

2.5.1.18

Glutathione metabolism

GO:0004364|glutathione transferase activity|IEA; GO:0008152|metabolism|IEA; GO:0016740|transferase activity|IEA

ACL00001126

Proline synthetase co-transcribed bacterial homolog protein related cluster

282

1e-24

47% (68/144)

General function prediction only

GO:0008784|alanine racemase activity|IEA; GO:0030170|pyridoxal phosphate binding|IEA

ACL00001128

unclassified

ACL00001129

unclassified

ACL00001130

unclassified

ACL00001131

Putative ABC transporter related cluster

139

2e-08

44% (22/50)

Defense mechanisms

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0016887|ATPase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

ACL00001133

RAS-related protein racE related cluster

122

6e-06

75% (24/32)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00001135

unclassified

ACL00001136

unclassified

ACL00001137

Coactosin related cluster

167

1e-11

42% (33/77)

GO:0003779|actin binding|IEA; GO:0005622|intracellular|IEA; GO:0005856|cytoskeleton|IEA

ACL00001138

unclassified

ACL00001139

unclassified

ACL00001140

CG11678

Actin-like protein 13E related cluster

58

3e-09

40% (12/30)

GO:0005198|structural molecule activity|IEA; GO:0005200|structural constituent of cytoskeleton|IEA; GO:0005634|nucleus|IEA; GO:0005856|cytoskeleton|IEA; GO:0015629|actin cytoskeleton|IEA

ACL00001141

Mitochondrial phosphate translocator related cluster

632

7e-65

54% (126/230)

GO:0005215|transporter activity|IEA; GO:0005488|binding|IEA; GO:0005743|mitochondrial inner membrane|IEA; GO:0006810|transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA

ACL00001143

[MG] COG0451 Nucleoside-diphosphate-sugar epimerases

120

2e-06

28% (52/185)

ACL00001144

unclassified

ACL00001145

Potassium transport protein 1 related cluster

234

9e-19

31% (63/203)

Inorganic ion transport and metabolism

GO:0006810|transport|IEA; GO:0006812|cation transport|IEA; GO:0006813|potassium ion transport|IEA; GO:0008324|cation transporter activity|IEA; GO:0015079|potassium ion transporter activity|IEA; GO:0016021|integral to membrane|IEA

ACL00001146

unclassified

ACL00001147

unclassified

ACL00001149

Tbcd

Similar to tubulin-specific chaperone D related cluster

140

2e-08

59% (25/42)

GO:0005488|binding|IEA

ACL00001151

TT_ORF1 domain containing protein

109

3e-06

55% (21/38)

ACL00001153

HRMT1L1

Protein arginine N-methyltransferase 2 related cluster

145

2e-59

36% (28/77)

2.1.1.-

Aminophosphonate metabolism Androgen and estrogen metabolism Histidine metabolism Nitrobenzene degradation Selenoamino acid metabolism Tryptophan metabolism Tyrosine metabolism Ubiquinone biosynthesis

GO:0004871|signal transducer activity|TAS; GO:0005634|nucleus|TAS; GO:0006479|protein amino acid methylation|TAS; GO:0007165|signal transduction|TAS; GO:0008168|methyltransferase activity|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00001154

unclassified

ACL00001155

unclassified

ACL00001156

IDHC

Isocitrate dehydrogenase [NADP] cytoplasmic related cluster

112

1e-165

76% (20/26)

1.1.1.42

Energy production and conversion

Citrate cycle (TCA cycle) Glutathione metabolism Reductive carboxylate cycle (CO2 fixation)

GO:0004450|isocitrate dehydrogenase (NADP+) activity|IEA; GO:0004450|isocitrate dehydrogenase (NADP+) activity|TAS; GO:0005777|peroxisome|IEA; GO:0005829|cytosol|TAS; GO:0005975|carbohydrate metabolism|TAS; GO:0006092|main pathways of carbohydrate metabolism|IEA; GO:0006097|glyoxylate cycle|IEA; GO:0006099|tricarboxylic acid cycle|IEA; GO:0006102|isocitrate metabolism|TAS; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00001157

unclassified

ACL00001158

METK

S-adenosylmethionine synthetase related cluster

247

6e-21

100% (44/44)

2.5.1.6

Coenzyme transport and metabolism

GO:0000287|magnesium ion binding|IEA; GO:0004478|methionine adenosyltransferase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006730|one-carbon compound metabolism|IEA; GO:0016740|transferase activity|IEA

ACL00001159

Calreticulin 2 precursor related cluster

605

8e-62

60% (110/183)

GO:0005509|calcium ion binding|IEA; GO:0005529|sugar binding|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0006457|protein folding|IEA; GO:0051082|unfolded protein binding|IEA

ACL00001160

unclassified

ACL00001161

V-ATPase_G domain containing protein

235

1e-20

38% (38/100)

ACL00001163

unclassified

ACL00001164

unclassified

ACL00001165

unclassified

ACL00001166

Proliferating cell nuclear antigen related cluster

236

1e-19

59% (41/69)

GO:0003677|DNA binding|IEA; GO:0005634|nucleus|IEA; GO:0005660|delta-DNA polymerase cofactor complex|IEA; GO:0006260|DNA replication|IEA; GO:0006275|regulation of DNA replication|IEA; GO:0030337|DNA polymerase processivity factor activity|IEA

ACL00001167

unclassified

ACL00001169

Subtilisin-like serine proteinase related cluster

79

4e-80

25% (17/67)

3.4.21.-

Posttranslational modification, protein turnover, chaperones

GO:0004252|serine-type endopeptidase activity|IEA; GO:0004289|subtilase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA; GO:0042802|protein self binding|IEA; GO:0043086|negative regulation of enzyme activity|IEA

ACL00001170

Unknown EST

111

5e-06

60% (21/35)

ACL00001171

unclassified

ACL00001172

Unassigned protein

264

1e-22

36% (58/159)

ACL00001173

unclassified

ACL00001174

unclassified

ACL00001175

unclassified

ACL00001176

unclassified

ACL00001177

unclassified

ACL00001178

Alternative oxidase related cluster

74

8e-39

43% (14/32)

GO:0005740|mitochondrial membrane|IEA; GO:0007585|respiratory gaseous exchange|IEA

ACL00001179

unclassified

ACL00001180

unclassified

ACL00001181

Unassigned protein

ACL00001182

unclassified

ACL00001183

unclassified

ACL00001184

Gelation factor related cluster

779

1e-81

44% (161/360)

GO:0003779|actin binding|IEA

ACL00001185

unclassified

ACL00001186

Transitional endoplasmic reticulum ATPase homolog 1 related cluster

128

4e-07

45% (18/40)

Posttranslational modification, protein turnover, chaperones

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0008151||IEA; GO:0016787|hydrolase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

ACL00001190

multi-domain protein

160

2e-11

21% (66/314)

ACL00001191

RPL36

60S ribosomal protein L36 related cluster

209

2e-16

47% (46/97)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0003735|structural constituent of ribosome|NAS; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0005842|cytosolic large ribosomal subunit (sensu Eukaryota)|NAS; GO:0006412|protein biosynthesis|IEA; GO:0006412|protein biosynthesis|NAS

ACL00001192

unclassified

ACL00001197

Unknown EST

192

1e-16

100% (40/40)

ACL00001198

unclassified

ACL00001199

26s protease regulatory subunit s10b related cluster

302

1e-134

67% (57/84)

Posttranslational modification, protein turnover, chaperones

Proteasome

GO:0005524|ATP binding|IEA; GO:0005634|nucleus|IEA; GO:0005737|cytoplasm|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA; GO:0030163|protein catabolism|IEA

ACL00001200

unclassified

ACL00001202

unclassified

ACL00001203

Herpes_gp2 domain containing protein

112

5e-06

25% (36/142)

ACL00001204

Acetyl/propionyl-CoA carboxylase, alpha subunit related cluster

116

1e-05

54% (26/48)

GO:0004075|biotin carboxylase activity|IEA; GO:0005524|ATP binding|IEA; GO:0008152|metabolism|IEA; GO:0009374|biotin binding|IEA; GO:0016874|ligase activity|IEA

ACL00001205

Putative MAGE related cluster

123

2e-06

34% (28/82)

ACL00001206

Similar to Dictyostelium discoideum (Slime mold). Pats1 related cluster

208

7e-16

32% (58/180)

GO:0004672|protein kinase activity|IEA; GO:0004713|protein-tyrosine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00001207

unclassified

ACL00001208

unclassified

ACL00001209

RPA4

DNA-dependent RNA polymerase 19 kDa polypeptide related cluster

136

5e-08

40% (25/61)

2.7.7.6

GO:0003677|DNA binding|IEA; GO:0003899|DNA-directed RNA polymerase activity|IC; GO:0003899|DNA-directed RNA polymerase activity|IEA; GO:0005634|nucleus|IEA; GO:0006350|transcription|IEA; GO:0016740|transferase activity|IEA

ACL00001210

unclassified

ACL00001211

unclassified

ACL00001212

Odz3

Odz3; odd Oz/ten-m homolog 3 (Drosophila)

162

7e-11

45% (29/64)

ACL00001213

tuf-1

Translation elongation factor Tu related cluster

841

5e-89

54% (161/293)

3.6.5.3

Translation, ribosomal structure and biogenesis

GO:0003746|translation elongation factor activity|IEA; GO:0005525|GTP binding|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006414|translational elongation|IEA

ACL00001215

unclassified

ACL00001216

unclassified

ACL00001217

multi-domain protein

157

3e-11

34% (53/155)

ACL00001218

unclassified

ACL00001220

Keratin_B2 domain containing protein

127

1e-07

22% (34/150)

ACL00001221

unclassified

ACL00001223

Lung seven transmembrane receptor 1 related cluster

266

4e-23

60% (47/78)

GO:0004872|receptor activity|IEA; GO:0016021|integral to membrane|IEA

ACL00001224

unclassified

ACL00001225

unclassified

ACL00001226

unclassified

ACL00001227

Unassigned protein

132

5e-07

42% (39/91)

ACL00001228

Chaperonin CPN60-1, mitochondrial precursor related cluster

145

4e-09

76% (32/42)

Posttranslational modification, protein turnover, chaperones

GO:0005524|ATP binding|IEA; GO:0005739|mitochondrion|IEA; GO:0006457|protein folding|IEA; GO:0006986|response to unfolded protein|IEA; GO:0051082|unfolded protein binding|IEA

ACL00001229

TPP1

Tripeptidyl-peptidase I precursor related cluster

148

2e-09

43% (38/88)

3.4.14.9

GO:0004252|serine-type endopeptidase activity|IEA; GO:0005764|lysosome|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA; GO:0019131|tripeptidyl-peptidase I activity|IEA

ACL00001230

Wdr5

WD-repeat protein 5 related cluster

92

8e-10

65% (19/29)

General function prediction only

ACL00001231

ilvE

Branched-chain amino acid aminotransferase related cluster

329

8e-30

31% (79/253)

2.6.1.42

Pantothenate and CoA biosynthesis Valine, leucine and isoleucine biosynthesis Valine, leucine and isoleucine degradation

GO:0003824|catalytic activity|IEA; GO:0004084|branched-chain-amino-acid transaminase activity|IEA; GO:0008152|metabolism|IEA; GO:0009081|branched chain family amino acid metabolism|IEA

ACL00001232

CG1637

CG1637; CG1637 gene product from transcript CG1637-RA

77

7e-07

46% (13/28)

ACL00001234

Similar to Fugu rubripes (Japanese pufferfish) (Takifugu rubripes). dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial related cluster

207

6e-16

40% (47/117)

2.3.1.61

Energy production and conversion

Citrate cycle (TCA cycle) Lysine degradation

GO:0004149|dihydrolipoyllysine-residue succinyltransferase activity|IEA; GO:0006099|tricarboxylic acid cycle|IEA; GO:0008152|metabolism|IEA; GO:0008415|acyltransferase activity|IEA; GO:0016740|transferase activity|IEA; GO:0045252|oxoglutarate dehydrogenase complex|IEA

ACL00001235

unclassified

ACL00001236

unclassified

ACL00001237

F9E11.8; kelch repeat-containing protein

195

4e-15

32% (47/144)

ACL00001238

Unassigned protein

75

3e-06

60% (14/23)

ACL00001239

Protein kinase C inhibitor related cluster

286

2e-25

54% (58/107)

GO:0016301|kinase activity|IEA

ACL00001240

Unknown EST

108

8e-06

80% (21/26)

ACL00001241

Unassigned protein

182

4e-13

39% (37/94)

ACL00001242

unclassified

ACL00001243

unclassified

ACL00001244

unclassified

ACL00001245

VERM

Tryptophan 2,3-dioxygenase related cluster

402

1e-38

52% (82/157)

1.13.11.11

Amino acid transport and metabolism

Tryptophan metabolism

GO:0004833|tryptophan 2,3-dioxygenase activity|IEA; GO:0006568|tryptophan metabolism|IEA; GO:0006727|ommochrome biosynthesis|IMP; GO:0016491|oxidoreductase activity|IEA; GO:0016702|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|IEA

ACL00001246

unclassified

ACL00001247

Unassigned protein

165

1e-10

27% (48/176)

ACL00001248

F14O23.22; transducin family protein / WD-40 repeat family protein

211

4e-16

25% (53/212)

General function prediction only

ACL00001250

Predicted nucleotide-binding protein related to universal stress protein UspA related cluster

91

6e-10

30% (22/73)

Signal transduction mechanisms

GO:0006950|response to stress|IEA

ACL00001251

hspa9b

Organellar heat shock protein related cluster

599

3e-61

63% (122/192)

GO:0005524|ATP binding|IEA; GO:0006457|protein folding|IEA; GO:0006986|response to unfolded protein|IEA

ACL00001252

unclassified

ACL00001253

PSA3

Proteasome subunit alpha type 3 related cluster

987

1e-106

95% (194/204)

3.4.25.1

Posttranslational modification, protein turnover, chaperones

Proteasome

GO:0004175|endopeptidase activity|IEA; GO:0005829|cytosol|IEA; GO:0005839|proteasome core complex (sensu Eukaryota)|IEA; GO:0006511|ubiquitin-dependent protein catabolism|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00001254

[U] COG5158 Proteins involved in synaptic transmission and general secretion, Sec1 family

216

2e-17

29% (63/212)

Intracellular trafficking, secretion, and vesicular transport

ACL00001255

unclassified

ACL00001256

Betaine aldehyde dehydrogenase, putative related cluster

202

1e-15

44% (41/92)

Energy production and conversion

GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00001257

Unassigned protein

ACL00001258

Unassigned protein

131

2e-07

33% (31/93)

ACL00001259

DCUP

Uroporphyrinogen decarboxylase related cluster

648

5e-67

62% (120/193)

4.1.1.37

Coenzyme transport and metabolism

Porphyrin and chlorophyll metabolism

GO:0004853|uroporphyrinogen decarboxylase activity|IEA; GO:0004853|uroporphyrinogen decarboxylase activity|TAS; GO:0006779|porphyrin biosynthesis|IEA; GO:0006783|heme biosynthesis|IEA; GO:0016829|lyase activity|IEA; GO:0016831|carboxy-lyase activity|IEA

ACL00001260

unclassified

ACL00001261

Unknown EST

64

3e-08

33% (12/36)

ACL00001262

ERG4

Probable sterol C-24 reductase related cluster

189

3e-14

45% (40/87)

1.3.1.71

GO:0016020|membrane|IEA

ACL00001263

Autoantigen related cluster

392

3e-37

39% (86/220)

GO:0008537|proteasome activator complex|IEA; GO:0008538|proteasome activator activity|IEA

ACL00001265

unclassified

ACL00001266

Arm repeat protein related cluster

129

7e-07

33% (37/112)

GO:0000151|ubiquitin ligase complex|IEA; GO:0004842|ubiquitin-protein ligase activity|IEA; GO:0005488|binding|IEA; GO:0016567|protein ubiquitination|IEA

ACL00001267

Cation transporting ATPase related cluster

174

2e-12

35% (30/84)

Inorganic ion transport and metabolism

GO:0005524|ATP binding|IEA; GO:0006812|cation transport|IEA; GO:0015662|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016787|hydrolase activity|IEA; GO:0016887|ATPase activity|IEA

ACL00001268

PSA6

Proteasome subunit alpha type 6 related cluster

778

6e-82

63% (150/235)

3.4.25.1

Posttranslational modification, protein turnover, chaperones

Proteasome

GO:0004175|endopeptidase activity|IEA; GO:0005829|cytosol|IEA; GO:0005839|proteasome core complex (sensu Eukaryota)|IEA; GO:0006511|ubiquitin-dependent protein catabolism|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00001269

unclassified

ACL00001270

unclassified

ACL00001271

Cell division control protein 42 homolog related cluster

142

9e-09

70% (26/37)

GO:0000910|cytokinesis|IEA; GO:0005525|GTP binding|IEA; GO:0007049|cell cycle|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0009405|pathogenesis|IEA

ACL00001273

CBS domain protein related cluster

89

4e-08

25% (30/116)

General function prediction only

ACL00001274

unclassified

ACL00001275

unclassified

ACL00001276

unclassified

ACL00001277

unclassified

ACL00001278

unclassified

ACL00001279

[K] COG5190 TFIIF-interacting CTD phosphatases, including NLI-interacting factor

194

9e-15

36% (46/127)

Transcription

ACL00001280

Protein disulfide-isomerase related cluster

382

5e-36

51% (79/153)

GO:0005489|electron transporter activity|IEA; GO:0006118|electron transport|IEA; GO:0016853|isomerase activity|IEA

ACL00001281

Putative secreted hydrolase related cluster

125

1e-06

30% (42/138)

GO:0016787|hydrolase activity|IEA

ACL00001282

KRAS2

Ras-like protein rasD related cluster

52

6e-37

52% (9/17)

MAPK signaling pathway Regulation of actin cytoskeleton

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00001283

Similar to Pyrococcus furiosus. partial alanyl-tRNA synthetase matches COOH terminus related cluster

239

5e-20

47% (44/92)

General function prediction only

GO:0004812|tRNA ligase activity|IEA

ACL00001284

Similar to Arabidopsis thaliana (Mouse-ear cress). phosphonopyruvate decarboxylase-like protein related cluster

52

1e-106

56% (9/16)

GO:0003824|catalytic activity|IEA; GO:0046872|metal ion binding|IEA

ACL00001285

unclassified

ACL00001288

DUF887 domain containing protein

133

2e-08

19% (43/220)

ACL00001289

multi-domain protein

143

6e-10

26% (31/119)

ACL00001290

AKIN gamma related cluster

271

5e-23

27% (89/325)

ACL00001291

unclassified

ACL00001292

unclassified

ACL00001293

Similar to katanin p80 (WD40-containing) subunit B 1 related cluster

145

6e-09

25% (38/147)

General function prediction only

ACL00001294

unclassified

ACL00001295

unclassified

ACL00001296

unclassified

ACL00001297

unclassified

ACL00001298

NONCLATHRIN coat protein gamma - like protein related cluster

168

6e-33

54% (28/51)

Intracellular trafficking, secretion, and vesicular transport

GO:0005488|binding|IEA

ACL00001299

unclassified

ACL00001301

ADP_ribosyl_GH domain containing protein

115

1e-06

29% (20/68)

ACL00001303

unclassified

ACL00001304

TXNRD1

Thioredoxin glutathione reductase related cluster

266

4e-23

71% (45/63)

1.8.1.9

Pyrimidine metabolism

GO:0005489|electron transporter activity|IEA; GO:0005737|cytoplasm|IEA; GO:0006118|electron transport|IEA; GO:0015036|disulfide oxidoreductase activity|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016654|oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor|IEA; GO:0050660|FAD binding|IEA

ACL00001305

CG10849

Synaptic glycoprotein SC2 related cluster

633

6e-65

54% (128/233)

GO:0016021|integral to membrane|IEA

ACL00001306

Similar to Dictyostelium discoideum (Slime mold). GrfA related cluster

217

3e-17

37% (55/145)

ACL00001307

Putative bacterioferritin comigratory protein related cluster

268

7e-23

50% (57/114)

ACL00001308

Aminoalcoholphosphotransferase related cluster

142

1e-08

72% (27/37)

GO:0008654|phospholipid biosynthesis|IEA; GO:0016740|transferase activity|IEA

ACL00001309

HSGP25L2G

Glycoprotein 25L2 precursor related cluster

287

3e-25

39% (67/168)

GO:0005783|endoplasmic reticulum|IEA; GO:0006886|intracellular protein transport|IEA; GO:0008320|protein carrier activity|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA

ACL00001310

Unassigned protein

ACL00001311

VPS28 protein homolog related cluster

198

3e-15

48% (39/81)

GO:0006810|transport|IEA; GO:0015031|protein transport|IEA

ACL00001312

Importin-alpha re-exporter related cluster

125

4e-26

40% (22/54)

Cell cycle control, cell division, chromosome partitioning

GO:0000059|protein-nucleus import, docking|IEA; GO:0005488|binding|IEA; GO:0005634|nucleus|IEA; GO:0005643|nuclear pore|IEA; GO:0005737|cytoplasm|IEA; GO:0006810|transport|IEA; GO:0006915|apoptosis|IEA; GO:0008262|importin-alpha export receptor activity|IEA; GO:0008283|cell proliferation|IEA; GO:0008565|protein transporter activity|IEA; GO:0015031|protein transport|IEA

ACL00001313

DLDH

Dihydrolipoyl dehydrogenase, mitochondrial precursor related cluster

712

3e-74

67% (130/194)

1.8.1.4

Energy production and conversion

GO:0004148|dihydrolipoyl dehydrogenase activity|IDA; GO:0004148|dihydrolipoyl dehydrogenase activity|IEA; GO:0005737|cytoplasm|IEA; GO:0005739|mitochondrion|IEA; GO:0006118|electron transport|IEA; GO:0006546|glycine catabolism|IMP; GO:0006550|isoleucine catabolism|IMP; GO:0006552|leucine catabolism|IMP; GO:0006564|L-serine biosynthesis|IMP; GO:0006574|valine catabolism|IMP; GO:0009353|oxoglutarate dehydrogenase complex (sensu Eukaryota)|IDA; GO:0015036|disulfide oxidoreductase activity|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0042645|mitochondrial nucleoid|IDA; GO:0050660|FAD binding|IEA

ACL00001314

Glycine cleavage system H protein, mitochondrial precursor related cluster

344

1e-31

51% (75/147)

Amino acid transport and metabolism

GO:0005739|mitochondrion|IEA; GO:0005960|glycine cleavage complex|IEA; GO:0006546|glycine catabolism|IEA

ACL00001315

unclassified

ACL00001317

unclassified

ACL00001319

unclassified

ACL00001320

Calmodulin related cluster

72

1e-10

40% (18/44)

Phosphatidylinositol signaling system

GO:0005509|calcium ion binding|IEA

ACL00001323

unclassified

ACL00001324

Similar to Dictyostelium discoideum (Slime mold). GrfA related cluster

150

1e-09

37% (41/108)

ACL00001325

Unassigned protein

ACL00001326

unclassified

ACL00001328

unclassified

ACL00001333

PRDX2

Peroxiredoxin related cluster

675

4e-70

66% (124/186)

1.11.1.-

Posttranslational modification, protein turnover, chaperones

ACL00001334

CG5854

CG5854; CG5854 gene product from transcript CG5854-RA

555

6e-56

40% (120/295)

ACL00001336

6PGD

6-phosphogluconate dehydrogenase, decarboxylating related cluster

216

4e-17

80% (38/47)

1.1.1.44

Carbohydrate transport and metabolism

Pentose phosphate pathway

GO:0004616|phosphogluconate dehydrogenase (decarboxylating) activity|IEA; GO:0005489|electron transporter activity|TAS; GO:0006098|pentose-phosphate shunt|IEA; GO:0009051|pentose-phosphate shunt, oxidative branch|TAS; GO:0016491|oxidoreductase activity|IEA

ACL00001337

Putative GTP-binding protein related cluster

360

5e-34

65% (66/101)

General function prediction only

ACL00001338

unclassified

ACL00001340

Lys domain containing protein

115

1e-06

48% (21/43)

ACL00001341

multi-domain protein

120

5e-07

28% (47/167)

ACL00001343

Rab1

Ras-related protein Rab-1A related cluster

697

2e-72

66% (132/198)

GO:0005525|GTP binding|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0005794|Golgi apparatus|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00001345

Putative inosine-uridine preferring nucleoside hydrolase related cluster

209

1e-15

25% (88/343)

Nucleotide transport and metabolism

GO:0016787|hydrolase activity|IEA

ACL00001348

TRP

Tryptophan synthase related cluster

696

2e-72

56% (140/250)

4.2.1.20

Amino acid transport and metabolism

Phenylalanine, tyrosine and tryptophan biosynthesis

GO:0000162|tryptophan biosynthesis|IEA; GO:0003824|catalytic activity|IEA; GO:0004834|tryptophan synthase activity|IEA; GO:0006568|tryptophan metabolism|IEA; GO:0008152|metabolism|IEA; GO:0016829|lyase activity|IEA

ACL00001349

unclassified

ACL00001351

ENTPD8

Similar to Ca2+-dependent endoplasmic reticulum nucleoside diphosphatase related cluster

270

1e-23

52% (51/97)

3.6.1.6 3.6.1.5

Purine metabolism Pyrimidine metabolism

ACL00001354

Zinc finger transcription factor ZFP30 related cluster

133

1e-07

33% (33/100)

ACL00001355

Nras

Ras-like protein 1 related cluster

607

3e-62

70% (117/165)

MAPK signaling pathway Regulation of actin cytoskeleton

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00001356

unclassified

ACL00001357

Atp6v1h

Putative vacuolar ATPase subunit H protein related cluster

406

9e-39

43% (80/185)

3.6.3.14

Energy production and conversion

ATP synthesis Oxidative phosphorylation

GO:0000221|hydrogen-transporting ATPase V1 domain|IEA; GO:0000300|peripheral to membrane of membrane fraction|IEA; GO:0001671|ATPase stimulator activity|IEA; GO:0005488|binding|IEA; GO:0005524|ATP binding|IEA; GO:0015986|ATP synthesis coupled proton transport|IEA; GO:0046933|hydrogen-transporting ATP synthase activity, rotational mechanism|IEA; GO:0046961|hydrogen-transporting ATPase activity, rotational mechanism|IEA

ACL00001358

RasGAP domain containing protein

113

4e-06

29% (23/79)

ACL00001359

unclassified

ACL00001360

DM6 domain containing protein

90

6e-05

29% (31/105)

ACL00001361

potato_inhibit domain containing protein

142

3e-09

40% (24/59)

ACL00001362

Ras-like protein rasD related cluster

135

6e-08

45% (32/70)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00001364

unclassified

ACL00001365

unclassified

ACL00001366

unclassified

ACL00001367

unclassified

ACL00001368

Unknown EST

128

6e-08

55% (26/47)

ACL00001369

unclassified

ACL00001370

Rbm8

RNA-binding protein 8A related cluster

338

4e-31

46% (67/144)

General function prediction only

GO:0000004|biological_process unknown|ND; GO:0000398|nuclear mRNA splicing, via spliceosome|IEA; GO:0003723|RNA binding|IEA; GO:0003729|mRNA binding|NAS; GO:0005634|nucleus|IEA; GO:0005634|nucleus|NAS; GO:0005737|cytoplasm|IEA; GO:0005737|cytoplasm|NAS; GO:0006396|RNA processing|IEA; GO:0006397|mRNA processing|IEA; GO:0006406|mRNA-nucleus export|IEA; GO:0006810|transport|IEA

ACL00001371

Cytochrome b5 related cluster

165

4e-11

41% (31/75)

GO:0005792|microsome|IEA; GO:0006118|electron transport|IEA; GO:0016021|integral to membrane|IEA

ACL00001372

unclassified

ACL00001373

unclassified

ACL00001374

unclassified

ACL00001375

unclassified

ACL00001376

ACSL6

Long-chain-fatty-acid--CoA ligase 6 related cluster

176

1e-12

35% (36/102)

6.2.1.3

Lipid transport and metabolism

Fatty acid metabolism

GO:0000287|magnesium ion binding|IEA; GO:0003824|catalytic activity|IEA; GO:0004467|long-chain-fatty-acid-CoA ligase activity|IEA; GO:0004467|long-chain-fatty-acid-CoA ligase activity|NAS; GO:0005741|mitochondrial outer membrane|NAS; GO:0005778|peroxisomal membrane|NAS; GO:0005792|microsome|NAS; GO:0005886|plasma membrane|NAS; GO:0006631|fatty acid metabolism|IEA; GO:0006637|acyl-CoA metabolism|NAS; GO:0008152|metabolism|IEA; GO:0016874|ligase activity|IEA

ACL00001377

DUF298 domain containing protein

319

5e-30

43% (51/117)

ACL00001378

TRUB1

TruB pseudouridine synthase-like protein 1 related cluster

462

3e-45

48% (94/192)

GO:0004730|pseudouridylate synthase activity|IEA; GO:0006396|RNA processing|IEA; GO:0008033|tRNA processing|IEA

ACL00001380

unclassified

ACL00001381

Unassigned protein

124

3e-06

38% (38/99)

ACL00001382

TT_ORF1 domain containing protein

111

9e-06

43% (21/48)

ACL00001383

Metal-dependent phosphohydrolase related cluster

63

2e-24

47% (11/23)

GO:0003824|catalytic activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00001385

ARPC3

ARP2/3 complex 21 kDa subunit related cluster

434

3e-42

54% (84/155)

Regulation of actin cytoskeleton

GO:0005856|cytoskeleton|IEA; GO:0030833|regulation of actin filament polymerization|IEA

ACL00001386

FUMH

Fumarate hydratase, mitochondrial precursor related cluster

264

7e-23

83% (50/60)

4.2.1.2

GO:0003824|catalytic activity|IEA; GO:0004333|fumarate hydratase activity|IEA; GO:0005739|mitochondrion|IEA; GO:0006099|tricarboxylic acid cycle|IEA; GO:0006106|fumarate metabolism|IEA; GO:0016829|lyase activity|IEA; GO:0045239|tricarboxylic acid cycle enzyme complex|IEA

ACL00001387

Similar to Arabidopsis thaliana (Mouse-ear cress). synaptobrevin-like protein related cluster

474

1e-46

50% (95/188)

Intracellular trafficking, secretion, and vesicular transport

ACL00001388

Putative IPP isomerase related cluster

432

1e-41

47% (84/178)

5.3.3.2

Lipid transport and metabolism

Biosynthesis of steroids Terpenoid biosynthesis

GO:0004452|isopentenyl-diphosphate delta-isomerase activity|IEA; GO:0008299|isoprenoid biosynthesis|IEA; GO:0016853|isomerase activity|IEA

ACL00001389

KIAA0218

Putative deoxyribonuclease KIAA0218 related cluster

408

3e-39

43% (80/185)

3.1.21.-

GO:0004518|nuclease activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00001390

unclassified

ACL00001392

Similar to Hordeum vulgare carboxypeptidase D related cluster

199

3e-15

42% (39/91)

GO:0003824|catalytic activity|IEA; GO:0004180|carboxypeptidase activity|IEA; GO:0004185|serine carboxypeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA

ACL00001393

PRNPIP

Prion protein interacting protein 1 related cluster

134

1e-07

35% (34/97)

GO:0004527|exonuclease activity|IEA; GO:0005515|protein binding|IDA; GO:0005622|intracellular|IEA; GO:0005886|plasma membrane|TAS

ACL00001394

Putative SET protein, phospatase 2A inhibitor related cluster

192

1e-13

30% (42/138)

GO:0005634|nucleus|IEA; GO:0006334|nucleosome assembly|IEA

ACL00001396

fabG3

3-oxoacyl-(acyl-carrier protein) reductase related cluster

387

1e-36

39% (101/254)

1.1.1.100

Fatty acid biosynthesis (path 1)

GO:0004316|3-oxoacyl-[acyl-carrier protein] reductase activity|IEA; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00001398

Ras-like protein rasD related cluster

477

8e-47

55% (91/165)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00001399

PCNA_C domain containing protein

145

3e-10

57% (26/45)

ACL00001400

T13L16.5; FAT domain-containing protein / phosphatidylinositol 3- and 4-kinase family protein

250

8e-21

30% (62/205)

ACL00001401

MTM1

Myotubularin related cluster

228

1e-18

39% (50/128)

3.1.3.48

GO:0004721|phosphoprotein phosphatase activity|IEA; GO:0004722|protein serine/threonine phosphatase activity|NAS; GO:0004725|protein tyrosine phosphatase activity|IEA; GO:0004725|protein tyrosine phosphatase activity|NAS; GO:0004725|protein tyrosine phosphatase activity|TAS; GO:0006470|protein amino acid dephosphorylation|IEA; GO:0006470|protein amino acid dephosphorylation|NAS; GO:0006470|protein amino acid dephosphorylation|TAS; GO:0007517|muscle development|TAS; GO:0008151||TAS; GO:0008372|cellular_component unknown|ND; GO:0016787|hydrolase activity|IEA

ACL00001402

unclassified

ACL00001403

Putative peptidyl-prolyl cis-trans isomerase related cluster

263

9e-23

72% (47/65)

5.2.1.8

Posttranslational modification, protein turnover, chaperones

GO:0003755|peptidyl-prolyl cis-trans isomerase activity|IEA; GO:0006457|protein folding|IEA; GO:0016853|isomerase activity|IEA

ACL00001404

CETN2

Centrin 2 related cluster

127

1e-06

26% (39/149)

GO:0000910|cytokinesis|IEA; GO:0005509|calcium ion binding|IEA; GO:0005509|calcium ion binding|NAS; GO:0005813|centrosome|NAS; GO:0007067|mitosis|IEA; GO:0007067|mitosis|NAS

ACL00001405

aroG2, RSc0743

Probable phospho-2-dehydro-3-deoxyheptonate aldolase, PHE-sensitive (DAHP synthetase) protein related cluster

632

4e-65

61% (123/199)

2.5.1.54

Amino acid transport and metabolism

Phenylalanine, tyrosine and tryptophan biosynthesis

GO:0003849|3-deoxy-7-phosphoheptulonate synthase activity|IEA; GO:0009058|biosynthesis|IEA; GO:0009073|aromatic amino acid family biosynthesis|IEA; GO:0016829|lyase activity|IEA

ACL00001406

pfk

pfk; 6-phosphofructokinase [EC:2.7.1.11] [KO:K00850]

644

3e-66

45% (136/297)

2.7.1.11

Carbohydrate transport and metabolism

Fructose and mannose metabolism Galactose metabolism Glycolysis / Gluconeogenesis Pentose phosphate pathway

ACL00001407

nucleotide-sensitive chloride conductance regulator (ICln) family protein [Arabidopsis thaliana] dbj|BAA97193.1| unnamed protein product [Arabidopsis thaliana] gb|AAM66035.1| unknown [Arabidopsis thaliana] dbj|BAC43583.1| unknown protein [Arabidopsis thaliana] gb|AAO63849.1| unknown protein [Arabidopsis thaliana]

156

6e-10

34% (42/121)

ACL00001408

Dimethyladenosine transferase related cluster

453

2e-44

49% (100/201)

Translation, ribosomal structure and biogenesis

GO:0000154|rRNA modification|IEA; GO:0000179|rRNA (adenine-N6,N6-)-dimethyltransferase activity|IEA; GO:0006364|rRNA processing|IEA; GO:0008168|methyltransferase activity|IEA; GO:0008649|rRNA methyltransferase activity|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA; GO:0016433|rRNA (adenine) methyltransferase activity|IEA; GO:0016740|transferase activity|IEA; GO:0046677|response to antibiotic|IEA

ACL00001409

unclassified

ACL00001410

unclassified

ACL00001411

AOF

Amine oxidase [flavin-containing] related cluster

90

1e-20

45% (16/35)

1.4.3.4

Amino acid transport and metabolism

GO:0005739|mitochondrion|IEA; GO:0006118|electron transport|IEA; GO:0008131|amine oxidase activity|IEA; GO:0016021|integral to membrane|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00001412

VATO

Probable vacuolar ATP synthase 20 kDa proteolipid subunit related cluster

404

8e-39

60% (80/132)

3.6.3.14

Energy production and conversion

ATP synthesis Oxidative phosphorylation

GO:0006754|ATP biosynthesis|IEA; GO:0015078|hydrogen ion transporter activity|IEA; GO:0015986|ATP synthesis coupled proton transport|IEA; GO:0015992|proton transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016469|proton-transporting two-sector ATPase complex|IEA; GO:0016787|hydrolase activity|IEA; GO:0046933|hydrogen-transporting ATP synthase activity, rotational mechanism|IEA; GO:0046961|hydrogen-transporting ATPase activity, rotational mechanism|IEA

ACL00001413

unclassified

ACL00001414

Glutathione S-transferase related cluster

471

1e-46

51% (96/186)

Posttranslational modification, protein turnover, chaperones

GO:0003824|catalytic activity|IEA; GO:0005737|cytoplasm|IEA; GO:0009072|aromatic amino acid family metabolism|IEA; GO:0016740|transferase activity|IEA

ACL00001415

unclassified

ACL00001416

DUS12

Dual specificity protein phosphatase 12 related cluster

220

9e-18

36% (41/112)

3.1.3.16

Signal transduction mechanisms

GO:0004721|phosphoprotein phosphatase activity|IEA; GO:0006470|protein amino acid dephosphorylation|IEA; GO:0008138|protein tyrosine/serine/threonine phosphatase activity|IDA; GO:0008138|protein tyrosine/serine/threonine phosphatase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00001417

unclassified

ACL00001419

Putative transformer serine/arginine-rich ribonucleoprotein related cluster

269

6e-23

52% (54/103)

GO:0003723|RNA binding|IEA; GO:0019013|viral nucleocapsid|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00001420

Unassigned protein

ACL00001421

unclassified

ACL00001425

unclassified

ACL00001426

unclassified

ACL00001429

unclassified

ACL00001430

Ras-like protein rasS related cluster

150

1e-09

68% (28/41)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00001431

unclassified

ACL00001432

unclassified

ACL00001434

Frataxin homolog related cluster

235

2e-19

47% (47/99)

Inorganic ion transport and metabolism

GO:0005739|mitochondrion|IEA; GO:0006879|iron ion homeostasis|IEA

ACL00001436

unclassified

ACL00001437

PH domain containing protein

139

2e-09

25% (29/114)

ACL00001438

unclassified

ACL00001439

unclassified

ACL00001440

unclassified

ACL00001442

RWD domain containing protein 1 related cluster

189

1e-13

29% (55/189)

ACL00001444

unclassified

ACL00001445

Putative ubiquitin carboxyl-terminal hydrolase related cluster

143

7e-09

42% (30/71)

GO:0004197|cysteine-type endopeptidase activity|IEA; GO:0004221|ubiquitin thiolesterase activity|IEA; GO:0006511|ubiquitin-dependent protein catabolism|IEA; GO:0016787|hydrolase activity|IEA

ACL00001446

unclassified

ACL00001447

Similar to Drosophila melanogaster (Fruit fly). RE12057p related cluster

162

1e-10

42% (36/84)

ACL00001448

unclassified

ACL00001449

atsC

atsC; short chain dehydrogenase

175

9e-13

40% (50/122)

ACL00001452

tif211

Eukaryotic translation initiation factor 2 alpha subunit related cluster

672

2e-69

48% (131/272)

Translation, ribosomal structure and biogenesis

GO:0003723|RNA binding|IEA; GO:0003743|translation initiation factor activity|IEA; GO:0006412|protein biosynthesis|IEA

ACL00001453

unclassified

ACL00001454

unclassified

ACL00001455

Similar to Mortierella alpina. stearoyl-CoA desaturase related cluster

838

1e-88

45% (148/325)

Lipid transport and metabolism

GO:0004768|stearoyl-CoA 9-desaturase activity|IEA; GO:0005506|iron ion binding|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0006633|fatty acid biosynthesis|IEA; GO:0006636|fatty acid desaturation|IEA; GO:0016020|membrane|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016717|oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water|IEA

ACL00001456

Mpv17

Similar to mouse MPV17 protein related cluster

277

8e-24

34% (65/188)

GO:0005743|mitochondrial inner membrane|IDA; GO:0006067|ethanol metabolism|IMP; GO:0016021|integral to membrane|IEA

ACL00001457

Microtubule associated protein related cluster

298

3e-26

52% (60/114)

ACL00001461

T26I12.100; splicing factor, putative

500

7e-50

61% (94/153)

ACL00001463

unclassified

ACL00001464

F14P22.40; universal stress protein (USP) family protein

206

9e-16

31% (52/166)

Signal transduction mechanisms

ACL00001469

unclassified

ACL00001476

CG9131

KISIR protein related cluster

236

5e-19

34% (57/166)

GO:0003700|transcription factor activity|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA

ACL00001480

unclassified

ACL00001482

unclassified

ACL00001483

[S] COG3803 Uncharacterized protein conserved in bacteria

267

3e-23

34% (68/200)

Function unknown

ACL00001485

Transketolase related cluster

313

3e-28

48% (64/131)

2.2.1.1

Carbohydrate transport and metabolism

Carbon fixation Pentose phosphate pathway

GO:0004802|transketolase activity|IEA

ACL00001486

unclassified

ACL00001488

Unassigned protein

160

8e-11

67% (31/46)

ACL00001489

F21F14.160; O-methyltransferase family 3 protein

86

2e-20

39% (15/38)

General function prediction only

ACL00001490

unclassified

ACL00001491

unclassified

ACL00001492

unclassified

ACL00001493

unclassified

ACL00001494

ybbC [Bacillus subtilis subsp. subtilis str. 168] sp|P40407|YBBC_BACSU Hypothetical protein ybbC precursor (ORF2) pir||I39840 hypothetical protein ybbC - Bacillus subtilis gb|AAA64352.1| 19/20 residue stretch (32-51) identical to N-terminal putative signal sequence of unknown, partly cloned B. subtilis gene.; putative dbj|BAA19498.1| YbbC [Bacillus subtilis] emb|CAB11941.1| ybbC [Bacillus subtilis subsp. subtilis str. 168]

164

1e-10

37% (47/126)

ACL00001495

unclassified

ACL00001496

Cullin domain containing protein

103

3e-06

54% (13/24)

ACL00001497

Similar to yeast BET3 involved in targeting and fusion of ER to golgi transport vesicles related cluster

393

2e-37

47% (87/183)

Intracellular trafficking, secretion, and vesicular transport

ACL00001498

unclassified

ACL00001499

unclassified

ACL00001500

Putative Lon2 protease related cluster

365

1e-34

65% (70/107)

3.4.21.-

Posttranslational modification, protein turnover, chaperones

GO:0000166|nucleotide binding|IEA; GO:0004176|ATP-dependent peptidase activity|IEA; GO:0004252|serine-type endopeptidase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0006510|ATP-dependent proteolysis|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

ACL00001502

D-ribulose-5-phosphate 3-epimerase related cluster

655

1e-67

60% (130/215)

Carbohydrate transport and metabolism

GO:0004750|ribulose-phosphate 3-epimerase activity|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0016853|isomerase activity|IEA

ACL00001503

unclassified

ACL00001504

Histone H2A related cluster

167

1e-11

47% (39/82)

Chromatin structure and dynamics

GO:0000786|nucleosome|IEA; GO:0003677|DNA binding|IEA; GO:0005634|nucleus|IEA; GO:0005694|chromosome|IEA; GO:0006334|nucleosome assembly|IEA; GO:0007001|chromosome organization and biogenesis (sensu Eukaryota)|IEA

ACL00001505

ODD OZ protein related cluster

146

3e-08

31% (39/123)

GO:0005887|integral to plasma membrane|IDA; GO:0007155|cell adhesion|IMP; GO:0008360|regulation of cell shape|IMP

ACL00001507

TKT1

Transketolase 1 related cluster

272

8e-24

81% (50/61)

2.2.1.1

Carbohydrate transport and metabolism

GO:0004802|transketolase activity|IEA; GO:0004802|transketolase activity|IMP; GO:0005509|calcium ion binding|IEA; GO:0006098|pentose-phosphate shunt|IMP; GO:0016740|transferase activity|IEA

ACL00001509

unclassified

ACL00001513

Putative glycohydrolase related cluster

154

7e-10

28% (49/173)

Posttranslational modification, protein turnover, chaperones

GO:0016787|hydrolase activity|IEA

ACL00001515

Microsomal signal peptidase 23 kDa subunit related cluster

252

2e-21

40% (54/134)

GO:0005783|endoplasmic reticulum|IEA; GO:0005787|signal peptidase complex|IEA; GO:0005792|microsome|IEA; GO:0006465|signal peptide processing|IEA; GO:0008233|peptidase activity|IEA; GO:0009003|signal peptidase activity|IEA; GO:0016021|integral to membrane|IEA; GO:0016787|hydrolase activity|IEA

ACL00001516

C43BP

Goodpasture antigen-binding protein related cluster

122

6e-06

31% (54/174)

2.7.1.37

GO:0004672|protein kinase activity|IEA; GO:0004672|protein kinase activity|TAS; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0006468|protein amino acid phosphorylation|TAS; GO:0006955|immune response|NAS; GO:0008372|cellular_component unknown|ND; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00001517

GPDA

Glycerol-3-phosphate dehydrogenase [NAD(P)+] related cluster

371

9e-35

38% (81/212)

1.1.1.94

Energy production and conversion

GO:0004367|glycerol-3-phosphate dehydrogenase (NAD+) activity|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0006072|glycerol-3-phosphate metabolism|IEA; GO:0008654|phospholipid biosynthesis|IEA; GO:0009331|glycerol-3-phosphate dehydrogenase complex|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016614|oxidoreductase activity, acting on CH-OH group of donors|IEA; GO:0016616|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|IEA; GO:0046167|glycerol-3-phosphate biosynthesis|IEA; GO:0047952|glycerol-3-phosphate dehydrogenase [NAD(P)+] activity|IEA

ACL00001520

multi-domain protein

120

6e-07

27% (22/80)

ACL00001521

unclassified

ACL00001522

unclassified

ACL00001523

unclassified

ACL00001524

unclassified

ACL00001525

Ssr1

Translocon-associated protein, alpha subunit precursor related cluster

110

5e-18

28% (25/89)

GO:0005048|signal sequence binding|TAS; GO:0005509|calcium ion binding|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0005783|endoplasmic reticulum|TAS; GO:0006613|cotranslational protein-membrane targeting|TAS; GO:0008284|positive regulation of cell proliferation|TAS; GO:0016021|integral to membrane|IEA; GO:0016021|integral to membrane|TAS

ACL00001526

unclassified

ACL00001527

unclassified

ACL00001528

unclassified

ACL00001529

unclassified

ACL00001530

unclassified

ACL00001532

unclassified

ACL00001533

unclassified

ACL00001534

unclassified

ACL00001535

unclassified

ACL00001536

unclassified

ACL00001537

Pin

Dynein light chain related cluster

244

1e-20

66% (41/62)

GO:0003774|motor activity|IEA; GO:0003777|microtubule motor activity|IEA; GO:0005875|microtubule associated complex|IEA; GO:0007017|microtubule-based process|IEA; GO:0030286|dynein complex|IEA

ACL00001538

unclassified

ACL00001539

PSA1

Proteasome subunit alpha type 1 related cluster

811

1e-85

63% (153/241)

3.4.25.1

Posttranslational modification, protein turnover, chaperones

GO:0004175|endopeptidase activity|IEA; GO:0005829|cytosol|IEA; GO:0005839|proteasome core complex (sensu Eukaryota)|IEA; GO:0006511|ubiquitin-dependent protein catabolism|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00001542

unclassified

ACL00001543

unclassified

ACL00001544

ankyrin G

192

3e-14

42% (46/107)

General function prediction only

ACL00001545

SOF1 protein-like protein related cluster

174

2e-12

46% (36/77)

ACL00001547

unclassified

ACL00001548

calmodulin [KO:K02183]

169

8e-12

32% (36/112)

Phosphatidylinositol signaling system

ACL00001549

unclassified

ACL00001550

Similar to phenylalanine-tRNA synthetase related cluster

162

5e-11

33% (33/99)

GO:0004812|tRNA ligase activity|IEA; GO:0004826|phenylalanine-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006432|phenylalanyl-tRNA aminoacylation|IEA

ACL00001551

unclassified

ACL00001552

unclassified

ACL00001553

Rpl22

Ribosomal protein L22 related cluster

257

1e-21

50% (50/99)

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00001554

Aminopeptidase related cluster

303

3e-27

42% (63/148)

Amino acid transport and metabolism

GO:0004177|aminopeptidase activity|IEA; GO:0004179|membrane alanyl aminopeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA

ACL00001555

Sod1

Superoxide dismutase related cluster

475

6e-47

61% (89/144)

1.15.1.1

Inorganic ion transport and metabolism

Amyotrophic lateral sclerosis (ALS) Neurodegenerative Disorders

GO:0004784|superoxide dismutase activity|IEA; GO:0004785|copper, zinc superoxide dismutase activity|IEA; GO:0006801|superoxide metabolism|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0046872|metal ion binding|IEA

ACL00001556

unclassified

ACL00001557

Rplp1

60S acidic ribosomal protein P1 related cluster

138

6e-08

45% (26/57)

Translation, ribosomal structure and biogenesis

GO:0003723|RNA binding|TAS; GO:0003735|structural constituent of ribosome|IEA; GO:0003735|structural constituent of ribosome|TAS; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0005842|cytosolic large ribosomal subunit (sensu Eukaryota)|TAS; GO:0006412|protein biosynthesis|IEA; GO:0006412|protein biosynthesis|TAS; GO:0006414|translational elongation|IEA

ACL00001559

unclassified

ACL00001560

unclassified

ACL00001561

unclassified

ACL00001562

unclassified

ACL00001563

Calreticulin precursor related cluster

354

6e-33

54% (67/124)

GO:0005509|calcium ion binding|IEA; GO:0005529|sugar binding|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0006457|protein folding|IEA; GO:0051082|unfolded protein binding|IEA

ACL00001564

unclassified

ACL00001565

unclassified

ACL00001566

unclassified

ACL00001567

Putative acyl carrier protein, mitochondrial precursor related cluster

221

1e-17

50% (42/83)

1.6.5.3 1.6.99.3

Oxidative phosphorylation

GO:0000036|acyl carrier activity|IEA; GO:0005739|mitochondrion|IEA; GO:0006633|fatty acid biosynthesis|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0048037|cofactor binding|IEA

ACL00001569

unclassified

ACL00001570

putative translation initiation factor protein [KO:K02519]

126

4e-06

32% (53/165)

Translation, ribosomal structure and biogenesis

ACL00001572

Unassigned protein

ACL00001573

unclassified

ACL00001574

Arginine/serine-rich splicing factor RSP41 related cluster

278

4e-24

46% (61/130)

GO:0003723|RNA binding|IEA; GO:0005634|nucleus|IEA

ACL00001575

unclassified

ACL00001576

RRNA methylase, putative related cluster

137

5e-08

51% (33/64)

2.1.1.-

Translation, ribosomal structure and biogenesis

GO:0003723|RNA binding|IEA; GO:0006396|RNA processing|IEA; GO:0008168|methyltransferase activity|IEA; GO:0008173|RNA methyltransferase activity|IEA; GO:0009451|RNA modification|IEA

ACL00001577

unclassified

ACL00001578

unclassified

ACL00001579

unclassified

ACL00001581

Putative glucanase related cluster

553

7e-56

45% (106/234)

GO:0004553|hydrolase activity, hydrolyzing O-glycosyl compounds|IEA; GO:0005975|carbohydrate metabolism|IEA

ACL00001582

unclassified

ACL00001583

RBSK

Ribokinase related cluster

360

7e-34

49% (79/160)

2.7.1.15

Carbohydrate transport and metabolism

Pentose phosphate pathway

GO:0004747|ribokinase activity|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0006014|D-ribose metabolism|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00001584

Solanesyl pyrophosphate synthase related cluster

117

8e-06

41% (23/56)

Coenzyme transport and metabolism

GO:0008299|isoprenoid biosynthesis|IEA; GO:0016740|transferase activity|IEA; GO:0050347|trans-octaprenyltranstransferase activity|IEA

ACL00001585

unclassified

ACL00001586

U6 snRNA-associated Sm-like protein LSm5 related cluster

262

1e-22

68% (50/73)

Transcription

GO:0000398|nuclear mRNA splicing, via spliceosome|IEA; GO:0003723|RNA binding|IEA; GO:0003723|RNA binding|TAS; GO:0005634|nucleus|IEA; GO:0005634|nucleus|TAS; GO:0005732|small nucleolar ribonucleoprotein complex|IEA; GO:0006397|mRNA processing|IEA; GO:0006397|mRNA processing|TAS; GO:0008248|pre-mRNA splicing factor activity|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00001587

unclassified

ACL00001589

unclassified

ACL00001590

Thioredoxin related cluster

248

1e-20

52% (49/94)

GO:0005489|electron transporter activity|IEA; GO:0006118|electron transport|IEA

ACL00001592

Unassigned protein

ACL00001593

unclassified

ACL00001595

unclassified

ACL00001596

Protein translation factor SUI1 homolog related cluster

114

6e-19

47% (26/55)

Translation, ribosomal structure and biogenesis

GO:0003743|translation initiation factor activity|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006413|translational initiation|IEA; GO:0006417|regulation of protein biosynthesis|IEA; GO:0006445|regulation of translation|IEA

ACL00001597

unclassified

ACL00001599

unclassified

ACL00001600

Putative glutamine synthetase related cluster

151

9e-10

48% (31/64)

Nucleotide transport and metabolism

GO:0003824|catalytic activity|IEA

ACL00001601

Fbxw7

F-box/WD-repeat protein 7 related cluster

274

1e-23

37% (55/145)

Neurodegenerative Disorders

GO:0003700|transcription factor activity|IDA; GO:0005515|protein binding|IPI; GO:0005634|nucleus|IDA; GO:0005634|nucleus|IEA; GO:0005737|cytoplasm|TAS; GO:0005783|endoplasmic reticulum|IDA; GO:0005794|Golgi apparatus|IDA; GO:0006512|ubiquitin cycle|IEA; GO:0007219|Notch signaling pathway|IDA

ACL00001602

Rac1

Rac related cluster

641

5e-66

64% (125/195)

Cadherin-mediated cell adhesion MAPK signaling pathway Regulation of actin cytoskeleton Toll-like receptor signaling pathway Wnt signaling pathway

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00001603

multi-domain protein

115

2e-06

27% (29/105)

ACL00001604

PUTATIVE CYTOSOLIC NADP-MALIC ENZYME

342

4e-32

51% (64/125)

Energy production and conversion

ACL00001605

unclassified

ACL00001606

unclassified

ACL00001607

Generic methyltransferase related cluster

142

1e-08

42% (27/64)

GO:0005554|molecular_function unknown|IEA; GO:0008168|methyltransferase activity|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00001608

unclassified

ACL00001609

Herpes_gp2 domain containing protein

118

7e-07

26% (43/162)

ACL00001611

T20F21.13; dual specificity protein phosphatase family protein

231

9e-19

40% (56/140)

Signal transduction mechanisms

ACL00001612

Putative ribosomal RNA methyltransferase 1 related cluster

252

3e-48

85% (46/54)

GO:0006364|rRNA processing|IEA; GO:0008168|methyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00001613

unclassified

ACL00001614

unclassified

ACL00001615

DCOR2

Ornithine decarboxylase 2 related cluster

304

1e-84

45% (59/131)

4.1.1.17

Amino acid transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0004586|ornithine decarboxylase activity|IEA; GO:0006596|polyamine biosynthesis|IEA; GO:0016829|lyase activity|IEA; GO:0016831|carboxy-lyase activity|IEA

ACL00001616

unclassified

ACL00001619

HEXA

Beta-hexosaminidase A precursor related cluster

175

2e-36

40% (37/91)

3.2.1.52

Carbohydrate transport and metabolism

GO:0004563|beta-N-acetylhexosaminidase activity|IEA; GO:0005764|lysosome|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0016787|hydrolase activity|IEA; GO:0016798|hydrolase activity, acting on glycosyl bonds|IEA

ACL00001620

Unknown EST

64

8e-07

50% (9/18)

ACL00001621

unclassified

ACL00001623

unclassified

ACL00001625

unclassified

ACL00001626

60S ribosomal protein L4-1 related cluster

452

4e-44

54% (95/175)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00001628

unclassified

ACL00001629

NFS1

Probable cysteine desulfurase, mitochondrial precursor related cluster

363

2e-34

67% (74/109)

2.8.1.7

Amino acid transport and metabolism

GO:0005739|mitochondrion|IEA; GO:0008152|metabolism|IEA; GO:0008483|transaminase activity|IEA; GO:0016740|transferase activity|IEA; GO:0031071|cysteine desulfurase activity|IEA

ACL00001630

Unknown EST

258

2e-25

61% (53/86)

ACL00001631

unclassified

ACL00001633

unclassified

ACL00001634

unclassified

ACL00001635

DHCA

Carbonyl reductase [NADPH] 1 related cluster

462

2e-45

49% (102/205)

1.1.1.184

Prostaglandin and leukotriene metabolism

GO:0004090|carbonyl reductase (NADPH) activity|IEA; GO:0004090|carbonyl reductase (NADPH) activity|TAS; GO:0005829|cytosol|NR; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0047021|15-hydroxyprostaglandin dehydrogenase (NADP+) activity|IEA; GO:0050221|prostaglandin-E2 9-reductase activity|IEA

ACL00001637

Probable phospho-2-dehydro-3-deoxyheptonate aldolase related cluster

718

6e-75

63% (146/229)

2.5.1.54

Phenylalanine, tyrosine and tryptophan biosynthesis

GO:0003849|3-deoxy-7-phosphoheptulonate synthase activity|IEA; GO:0009058|biosynthesis|IEA; GO:0009073|aromatic amino acid family biosynthesis|IEA; GO:0016829|lyase activity|IEA

ACL00001638

Probable homocitrate synthase, mitochondrial isozyme precursor(ec 4.1.3.21) related cluster

439

7e-43

71% (81/114)

2.3.3.14

Amino acid transport and metabolism

Lysine biosynthesis Pyruvate metabolism

GO:0003824|catalytic activity|IEA; GO:0008152|metabolism|IEA; GO:0016740|transferase activity|IEA; GO:0016829|lyase activity|IEA

ACL00001639

ABC transporter ABCA.7 related cluster

613

6e-63

58% (118/203)

Defense mechanisms

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0016887|ATPase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

ACL00001640

unclassified

ACL00001642

unclassified

ACL00001644

[J] COG0480 Translation elongation factors (GTPases)

117

2e-06

53% (24/45)

Translation, ribosomal structure and biogenesis

ACL00001645

unclassified

ACL00001646

asnS

asnS; probable asparagine-tRNA ligase [EC:6.1.1.22] [KO:K01893]

82

8e-10

63% (14/22)

6.1.1.22

Alanine and aspartate metabolism Aminoacyl-tRNA biosynthesis

ACL00001647

unclassified

ACL00001648

unclassified

ACL00001649

multi-domain protein

143

4e-11

27% (25/91)

ACL00001652

unclassified

ACL00001654

Unassigned protein

ACL00001655

Bap31 domain containing protein

132

2e-08

23% (38/162)

ACL00001656

HMDH2

3-hydroxy-3-methylglutaryl-coenzyme A reductase 2 related cluster

462

7e-46

78% (87/111)

1.1.1.34

Lipid transport and metabolism

GO:0004420|hydroxymethylglutaryl-CoA reductase (NADPH) activity|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0006629|lipid metabolism|IEA; GO:0006695|cholesterol biosynthesis|IEA; GO:0009058|biosynthesis|IEA; GO:0016021|integral to membrane|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00001657

unclassified

ACL00001658

unclassified

ACL00001659

Unknown EST

122

9e-07

35% (25/70)

ACL00001660

Homologue of Sarcophaga 26,29kDa proteinase related cluster

130

2e-07

33% (40/121)

GO:0004197|cysteine-type endopeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008233|peptidase activity|IEA; GO:0008234|cysteine-type peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00001661

Peroxisomal-coenzyme A synthetase related cluster

176

1e-12

66% (37/56)

GO:0003824|catalytic activity|IEA; GO:0005737|cytoplasm|IDA; GO:0005777|peroxisome|IEA; GO:0005778|peroxisomal membrane|IDA; GO:0005782|peroxisomal matrix|IDA; GO:0008152|metabolism|IEA; GO:0016874|ligase activity|IEA

ACL00001664

unclassified

ACL00001665

Exostosin domain containing protein

138

5e-10

43% (18/41)

ACL00001666

unclassified

ACL00001667

unclassified

ACL00001668

SYT

Threonyl-tRNA synthetase, mitochondrial precursor related cluster

184

1e-13

46% (38/81)

6.1.1.3

Translation, ribosomal structure and biogenesis

Aminoacyl-tRNA biosynthesis Glycine, serine and threonine metabolism

GO:0004812|tRNA ligase activity|IEA; GO:0004829|threonine-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0005739|mitochondrion|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006418|tRNA aminoacylation for protein translation|IEA; GO:0006435|threonyl-tRNA aminoacylation|IEA; GO:0016874|ligase activity|IEA

ACL00001669

Putative protein with similarity to putative prostate cancer tumor suppressor related cluster

135

3e-07

21% (69/314)

ACL00001671

RPB7

DNA-directed RNA polymerase II 19 kDa polypeptide related cluster

577

1e-58

61% (108/176)

2.7.7.6

Transcription

Purine metabolism Pyrimidine metabolism RNA polymerase

GO:0003723|RNA binding|IEA; GO:0003899|DNA-directed RNA polymerase activity|IEA; GO:0005634|nucleus|IEA; GO:0006350|transcription|IEA; GO:0016740|transferase activity|IEA

ACL00001672

putative protein, with at least 8 transmembrane domains, a coiled coil-4 domain, of bilaterial origin (73.6 kD) (2L582) [Caenorhabditis elegans] pir||T20034 hypothetical protein C47G2.4 - Caenorhabditis elegans emb|CAA88936.1| Hypothetical protein C47G2.4 [Caenorhabditis elegans]

222

2e-17

32% (41/125)

ACL00001673

HSPC031 related cluster

513

2e-51

57% (101/176)

GO:0003723|RNA binding|IEA; GO:0005634|nucleus|IEA; GO:0007046|ribosome biogenesis|IEA

ACL00001675

[C] COG0277 FAD/FMN-containing dehydrogenases

138

7e-09

32% (38/118)

Energy production and conversion

ACL00001676

PEPM

Phosphoenolpyruvate phosphomutase related cluster

1059

1e-114

73% (206/281)

5.4.2.9

Aminophosphonate metabolism

GO:0000287|magnesium ion binding|IEA; GO:0003824|catalytic activity|IEA; GO:0008152|metabolism|IEA; GO:0016853|isomerase activity|IEA; GO:0050188|phosphoenolpyruvate mutase activity|IEA

ACL00001677

Unknown EST

121

3e-10

100% (23/23)

ACL00001678

Unknown EST

112

6e-06

45% (21/46)

ACL00001679

unclassified

ACL00001680

FAS1 domain containing protein

117

3e-08

28% (28/98)

ACL00001682

CG10117

TTV protein related cluster

126

1e-06

32% (32/98)

GO:0007224|smoothened signaling pathway|NAS; GO:0008151||IEA; GO:0015012|heparan sulfate proteoglycan biosynthesis|TAS; GO:0015014|heparan sulfate proteoglycan biosynthesis, polysaccharide chain biosynthesis|IMP; GO:0016020|membrane|IEA

ACL00001683

NIF3L1

NIF3-like protein 1 related cluster

159

1e-10

49% (31/63)

ACL00001684

Similar to Petunia hybrida (Petunia). proteasome subunit beta type 1 related cluster

601

2e-61

55% (120/218)

Posttranslational modification, protein turnover, chaperones

GO:0004175|endopeptidase activity|IEA; GO:0005829|cytosol|IEA; GO:0005839|proteasome core complex (sensu Eukaryota)|IEA; GO:0006511|ubiquitin-dependent protein catabolism|IEA

ACL00001685

GGT

Gamma-glutamyltranspeptidase precursor related cluster

134

8e-08

37% (28/75)

2.3.2.2

Amino acid transport and metabolism

Cyanoamino acid metabolism Glutathione metabolism Selenoamino acid metabolism Taurine and hypotaurine metabolism

GO:0003840|gamma-glutamyltransferase activity|IEA; GO:0006750|glutathione biosynthesis|IEA; GO:0008415|acyltransferase activity|IEA; GO:0016740|transferase activity|IEA; GO:0042597|periplasmic space|IEA

ACL00001686

WD-40 repeat protein

140

4e-08

26% (42/161)

General function prediction only

ACL00001687

Probable aldolase related cluster

54

1e-91

39% (11/28)

2.5.1.54

Phenylalanine, tyrosine and tryptophan biosynthesis

GO:0003849|3-deoxy-7-phosphoheptulonate synthase activity|IEA; GO:0009073|aromatic amino acid family biosynthesis|IEA

ACL00001688

unclassified

ACL00001689

Unassigned protein

ACL00001693

unclassified

ACL00001694

unclassified

ACL00001697

Tobacco mosaic virus helicase domain-binding protein related cluster

270

1e-23

49% (62/126)

GO:0000166|nucleotide binding|IEA; GO:0004386|helicase activity|IEA; GO:0005524|ATP binding|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

ACL00001698

Mito_carr domain containing protein

104

4e-06

40% (19/47)

ACL00001699

FMO5

Dimethylaniline monooxygenase [N-oxide forming] 5 related cluster

117

8e-06

46% (23/50)

1.14.13.8

GO:0000004|biological_process unknown|ND; GO:0004497|monooxygenase activity|IEA; GO:0004499|dimethylaniline monooxygenase (N-oxide-forming) activity|IEA; GO:0004499|dimethylaniline monooxygenase (N-oxide-forming) activity|NAS; GO:0005792|microsome|IEA; GO:0005792|microsome|NAS; GO:0006118|electron transport|IEA; GO:0015036|disulfide oxidoreductase activity|IEA; GO:0016021|integral to membrane|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00001700

unclassified

ACL00001701

COP9 signalosome complex subunit 1 related cluster

1078

1e-116

54% (222/405)

GO:0005634|nucleus|IEA; GO:0007275|development|IEA; GO:0008180|signalosome complex|IEA

ACL00001702

unclassified

ACL00001703

unclassified

ACL00001704

26S protease regulatory subunit 8 related cluster

1515

1e-167

84% (298/353)

Posttranslational modification, protein turnover, chaperones

GO:0000502|proteasome complex (sensu Eukaryota)|TAS; GO:0003712|transcription cofactor activity|TAS; GO:0006366|transcription from Pol II promoter|TAS; GO:0016887|ATPase activity|TAS

ACL00001705

unclassified

ACL00001706

P4Hc domain containing protein

173

1e-14

21% (30/138)

ACL00001707

EIF2B2

Translation initiation factor eIF-2B beta subunit related cluster

203

8e-16

52% (32/61)

Translation, ribosomal structure and biogenesis

GO:0003743|translation initiation factor activity|IEA; GO:0005525|GTP binding|IEA; GO:0005851|eukaryotic translation initiation factor 2B complex|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006413|translational initiation|IEA

ACL00001708

UNC93A

UNC93A protein precursor related cluster

228

5e-18

34% (46/135)

ACL00001709

LOC286426

Porin related cluster

122

2e-06

28% (38/133)

GO:0005741|mitochondrial outer membrane|IEA; GO:0006820|anion transport|IEA; GO:0008308|voltage-gated ion-selective channel activity|IEA; GO:0015288|porin activity|IEA; GO:0016021|integral to membrane|IEA; GO:0019867|outer membrane|IEA

ACL00001710

PRPK

p53-related protein kinase related cluster

196

1e-38

50% (40/80)

2.7.1.37

Signal transduction mechanisms

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005515|protein binding|IPI; GO:0005524|ATP binding|IEA; GO:0005634|nucleus|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016740|transferase activity|IEA

ACL00001711

Similar to COP9 homolog related cluster

319

7e-29

38% (60/157)

GO:0005634|nucleus|IEA; GO:0008180|signalosome complex|IEA

ACL00001712

unclassified

ACL00001713

Mvp

Major vault protein related cluster

224

3e-18

63% (42/66)

GO:0005634|nucleus|IEA; GO:0005634|nucleus|TAS; GO:0005737|cytoplasm|TAS; GO:0030529|ribonucleoprotein complex|IEA; GO:0042493|response to drug|TAS

ACL00001714

unclassified

ACL00001715

LOC381811

Calmodulin related cluster

172

3e-12

48% (28/58)

GO:0005921|gap junction|TAS

ACL00001716

multi-domain protein

128

2e-08

43% (28/64)

ACL00001717

TOB protein related cluster

147

1e-08

32% (37/115)

ACL00001718

Probable hydrolase related cluster

240

1e-19

31% (61/192)

General function prediction only

GO:0003824|catalytic activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00001719

unclassified

ACL00001722

unclassified

ACL00001723

FAAA

Fumarylacetoacetase related cluster

441

3e-43

59% (78/131)

3.7.1.2

Styrene degradation Tyrosine metabolism

GO:0003824|catalytic activity|IEA; GO:0004334|fumarylacetoacetase activity|IEA; GO:0004334|fumarylacetoacetase activity|TAS; GO:0006559|L-phenylalanine catabolism|IEA; GO:0006572|tyrosine catabolism|IEA; GO:0006572|tyrosine catabolism|TAS; GO:0008152|metabolism|IEA; GO:0009072|aromatic amino acid family metabolism|IEA; GO:0016787|hydrolase activity|IEA

ACL00001724

unclassified

ACL00001726

Eif4el3

Eukaryotic translation initiation factor 4E type 3 related cluster

535

7e-54

65% (93/141)

Translation, ribosomal structure and biogenesis

GO:0000339|RNA cap binding|TAS; GO:0003723|RNA binding|IEA; GO:0003743|translation initiation factor activity|IEA; GO:0005737|cytoplasm|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006413|translational initiation|IEA; GO:0006417|regulation of protein biosynthesis|IEA; GO:0006445|regulation of translation|IEA; GO:0006445|regulation of translation|TAS; GO:0008135|translation factor activity, nucleic acid binding|TAS

ACL00001728

multi-domain protein

112

2e-06

32% (26/79)

ACL00001729

unclassified

ACL00001730

OST3_OST6 domain containing protein

137

2e-09

32% (22/67)

ACL00001733

unclassified

ACL00001734

3-hydroxybutyryl-CoA dehydratase related cluster

147

9e-09

25% (54/214)

4.2.1.17

Lipid transport and metabolism

Butanoate metabolism

GO:0003824|catalytic activity|IEA; GO:0003859|3-hydroxybutyryl-CoA dehydratase activity|IEA; GO:0008152|metabolism|IEA; GO:0016829|lyase activity|IEA

ACL00001736

unclassified

ACL00001737

unclassified

ACL00001738

unclassified

ACL00001740

unclassified

ACL00001741

Probable N-hydroxyarylamine O-acetyltransferase related cluster

117

8e-06

40% (24/60)

Secondary metabolites biosynthesis, transport and catabolism

GO:0004060|arylamine N-acetyltransferase activity|IEA; GO:0008152|metabolism|IEA; GO:0008415|acyltransferase activity|IEA; GO:0016407|acetyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00001742

YPK1

Kinase Akt/PKB related cluster

332

9e-31

47% (59/124)

2.7.1.37

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00001743

RTPR

Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase related cluster

134

8e-08

39% (34/86)

1.17.4.2

GO:0003824|catalytic activity|IEA; GO:0006260|DNA replication|IEA; GO:0008998|ribonucleoside-triphosphate reductase activity|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00001744

multi-domain protein

146

8e-10

22% (62/271)

ACL00001745

Putative CMF receptor CMFR1 related cluster

672

2e-69

44% (153/341)

GO:0004497|monooxygenase activity|IEA; GO:0004872|receptor activity|IEA; GO:0006118|electron transport|IEA; GO:0006725|aromatic compound metabolism|IEA; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00001746

Transport protein particle component Bet3p-like protein related cluster

242

2e-20

58% (50/85)

ACL00001747

unclassified

ACL00001748

Unknown EST

135

5e-09

39% (27/69)

ACL00001750

unclassified

ACL00001751

unclassified

ACL00001752

unclassified

ACL00001753

Two-component hybrid sensor and regulator related cluster

159

3e-10

35% (33/93)

2.7.3.-

GO:0000155|two-component sensor molecule activity|IEA; GO:0000156|two-component response regulator activity|IEA; GO:0000160|two-component signal transduction system (phosphorelay)|IEA; GO:0003677|DNA binding|IEA; GO:0004871|signal transducer activity|IEA; GO:0005524|ATP binding|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0007165|signal transduction|IEA; GO:0007600|sensory perception|IEA; GO:0008020|G-protein coupled photoreceptor activity|IEA; GO:0016020|membrane|IEA; GO:0016301|kinase activity|IEA; GO:0016310|phosphorylation|IEA; GO:0016740|transferase activity|IEA; GO:0016772|transferase activity, transferring phosphorus-containing groups|IEA

ACL00001755

unclassified

ACL00001756

unclassified

ACL00001758

VATA2

Vacuolar ATP synthase catalytic subunit A, osteoclast isoform related cluster

727

3e-76

75% (137/181)

3.6.3.14

Energy production and conversion

GO:0005524|ATP binding|IEA; GO:0005886|plasma membrane|TAS; GO:0006754|ATP biosynthesis|IEA; GO:0015078|hydrogen ion transporter activity|IEA; GO:0015986|ATP synthesis coupled proton transport|IEA; GO:0015992|proton transport|IEA; GO:0015992|proton transport|TAS; GO:0016469|proton-transporting two-sector ATPase complex|IEA; GO:0016469|proton-transporting two-sector ATPase complex|TAS; GO:0016787|hydrolase activity|IEA; GO:0046933|hydrogen-transporting ATP synthase activity, rotational mechanism|IEA; GO:0046961|hydrogen-transporting ATPase activity, rotational mechanism|IEA

ACL00001759

SYC

Cysteinyl-tRNA synthetase related cluster

336

4e-31

45% (67/148)

6.1.1.16

Translation, ribosomal structure and biogenesis

GO:0004812|tRNA ligase activity|IEA; GO:0004817|cysteine-tRNA ligase activity|IDA; GO:0004817|cysteine-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0005737|cytoplasm|IDA; GO:0006412|protein biosynthesis|IEA; GO:0006423|cysteinyl-tRNA aminoacylation|IDA; GO:0006423|cysteinyl-tRNA aminoacylation|IEA; GO:0006534|cysteine metabolism|NAS; GO:0016874|ligase activity|IEA

ACL00001760

Unassigned protein

ACL00001761

Coronin related cluster

836

1e-88

53% (155/289)

GO:0003779|actin binding|IEA

ACL00001763

prosaposin [Bos taurus] dbj|BAA95677.1| prosaposin [Bos taurus]

126

2e-06

45% (27/60)

ACL00001764

unclassified

ACL00001765

unclassified

ACL00001766

unclassified

ACL00001767

F26H11.9; XAP5 family protein

255

6e-22

73% (44/60)

ACL00001768

unclassified

ACL00001769

Sod_Fe_C domain containing protein

109

5e-07

54% (13/24)

ACL00001770

unclassified

ACL00001771

unclassified

ACL00001772

unclassified

ACL00001774

unclassified

ACL00001775

TALDO

Transaldolase related cluster

279

1e-91

63% (53/84)

2.2.1.2

Carbohydrate transport and metabolism

Pentose phosphate pathway

GO:0004801|transaldolase activity|IEA; GO:0004801|transaldolase activity|TAS; GO:0005737|cytoplasm|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0005975|carbohydrate metabolism|TAS; GO:0006098|pentose-phosphate shunt|IEA; GO:0016740|transferase activity|IEA

ACL00001776

SapB domain containing protein

113

5e-08

26% (14/53)

ACL00001777

NAP domain containing protein

188

6e-15

48% (40/83)

ACL00001780

PMA1

Probable plasma membrane ATPase related cluster

326

3e-29

38% (68/175)

3.6.3.6

Inorganic ion transport and metabolism

GO:0000287|magnesium ion binding|IEA; GO:0003824|catalytic activity|IEA; GO:0005524|ATP binding|IEA; GO:0006812|cation transport|IEA; GO:0008152|metabolism|IEA; GO:0008553|hydrogen-exporting ATPase activity, phosphorylative mechanism|IEA; GO:0015078|hydrogen ion transporter activity|IEA; GO:0015662|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|IEA; GO:0015992|proton transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016787|hydrolase activity|IEA; GO:0016820|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|IEA; GO:0016887|ATPase activity|IEA

ACL00001781

CG9375

Ras-like protein 1 related cluster

127

5e-07

36% (34/93)

GO:0000082|G1/S transition of mitotic cell cycle|TAS; GO:0001558|regulation of cell growth|TAS; GO:0001708|cell fate specification|TAS; GO:0005525|GTP binding|IEA; GO:0005525|GTP binding|NAS; GO:0006916|anti-apoptosis|NAS; GO:0007048|oncogenesis|IGI; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0007298|border cell migration (sensu Insecta)|TAS; GO:0007391|dorsal closure|TAS; GO:0007428|primary tracheal branching (sensu Insecta)|TAS; GO:0007456|eye morphogenesis (sensu Endopterygota)|IMP; GO:0007472|wing disc metamorphosis|IMP; GO:0007476|wing morphogenesis|IMP; GO:0008293|torso signaling pathway|TAS; GO:0008372|cellular_component unknown|ND; GO:0008595|determination of anterior/posterior axis, embryo|TAS; GO:0016049|cell growth|TAS; GO:0030307|positive regulation of cell growth|TAS; GO:0030381|eggshell pattern formation (sensu Insecta)|IMP; GO:0030707|ovarian follicle cell development (sensu Insecta)|TAS; GO:0040008|regulation of growth|TAS; GO:0045500|sevenless signaling pathway|TAS; GO:0046673|negative regulation of retinal programmed cell death (sensu Endopterygota)|TAS

ACL00001782

unclassified

ACL00001783

Unassigned protein

65

1e-07

23% (27/114)

ACL00001784

GLGB

1,4-alpha-glucan branching enzyme related cluster

682

1e-70

56% (132/232)

2.4.1.18

Carbohydrate transport and metabolism

Starch and sucrose metabolism

GO:0003844|1,4-alpha-glucan branching enzyme activity|IEA; GO:0003844|1,4-alpha-glucan branching enzyme activity|TAS; GO:0004553|hydrolase activity, hydrolyzing O-glycosyl compounds|IEA; GO:0004556|alpha-amylase activity|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0005977|glycogen metabolism|IEA; GO:0005977|glycogen metabolism|TAS; GO:0005978|glycogen biosynthesis|IEA; GO:0006091|generation of precursor metabolites and energy|TAS; GO:0016740|transferase activity|IEA; GO:0016757|transferase activity, transferring glycosyl groups|IEA

ACL00001785

unclassified

ACL00001786

XAP-5 protein emb|CAB46282.1| XAP-5 protein [Mus musculus]

205

2e-15

32% (61/188)

ACL00001787

eIF-2beta

Eukaryotic translation initiation factor 2 beta subunit related cluster

363

8e-34

42% (75/176)

Translation, ribosomal structure and biogenesis

GO:0003743|translation initiation factor activity|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006413|translational initiation|IEA

ACL00001788

Cell division cycle protein 48 related cluster

192

2e-14

42% (37/87)

GO:0000166|nucleotide binding|IEA; GO:0000910|cytokinesis|IEA; GO:0005524|ATP binding|IEA; GO:0008151||IEA; GO:0016787|hydrolase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

ACL00001789

unclassified

ACL00001790

Unassigned protein

136

6e-08

31% (40/129)

ACL00001791

unclassified

ACL00001792

multi-domain protein

146

8e-10

21% (71/333)

ACL00001793

unclassified

ACL00001794

unclassified

ACL00001796

LOC151194

Hepatocellular carcinoma-associated antigen HCA557b related cluster

195

8e-15

43% (48/110)

ACL00001797

unclassified

ACL00001798

Cinnamyl alcohol dehydrogenase, putative related cluster

133

1e-07

64% (25/39)

ACL00001799

unclassified

ACL00001801

Unknown EST

104

2e-18

100% (20/20)

ACL00001802

S-adenosylmethionine:diacylglycerol 3-amino-3-carboxypropyl transferase related cluster

183

7e-13

28% (51/179)

Lipid transport and metabolism

GO:0016740|transferase activity|IEA

ACL00001803

unclassified

ACL00001804

UB2D1

Ubiquitin-conjugating enzyme E2-17 kDa 1 related cluster

445

7e-44

86% (77/89)

6.3.2.19

Posttranslational modification, protein turnover, chaperones

GO:0004840|ubiquitin conjugating enzyme activity|IEA; GO:0004840|ubiquitin conjugating enzyme activity|TAS; GO:0004842|ubiquitin-protein ligase activity|IEA; GO:0004842|ubiquitin-protein ligase activity|NR; GO:0006464|protein modification|IEA; GO:0006511|ubiquitin-dependent protein catabolism|TAS; GO:0006512|ubiquitin cycle|IEA; GO:0016874|ligase activity|IEA

ACL00001805

unclassified

ACL00001806

unclassified

ACL00001807

cpvl

Carboxypeptidase related cluster

196

5e-15

51% (34/66)

Amino acid transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0004180|carboxypeptidase activity|IEA; GO:0004185|serine carboxypeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA

ACL00001808

Unassigned protein

ACL00001809

Cyclic-AMP-dependent transcription factor ATF-6 beta related cluster

138

1e-07

35% (28/80)

GO:0000794|condensed nuclear chromosome|ISS; GO:0003677|DNA binding|IEA; GO:0005515|protein binding|ISS; GO:0005634|nucleus|IEA; GO:0005769|early endosome|ISS; GO:0005783|endoplasmic reticulum|IEA; GO:0005815|microtubule organizing center|ISS; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006986|response to unfolded protein|IEA; GO:0007076|mitotic chromosome condensation|ISS; GO:0012505|endomembrane system|ISS; GO:0016021|integral to membrane|IEA; GO:0016363|nuclear matrix|ISS; GO:0016458|gene silencing|ISS; GO:0045014|negative regulation of transcription by glucose|ISS; GO:0045749|negative regulation of S phase of mitotic cell cycle|ISS; GO:0045892|negative regulation of transcription, DNA-dependent|ISS

ACL00001811

unclassified

ACL00001812

unclassified

ACL00001814

Unassigned protein

123

4e-06

34% (30/88)

ACL00001815

Probable sensor/response regulator hybrid related cluster

238

7e-20

48% (57/118)

GO:0000155|two-component sensor molecule activity|IEA; GO:0000156|two-component response regulator activity|IEA; GO:0000160|two-component signal transduction system (phosphorelay)|IEA; GO:0003677|DNA binding|IEA; GO:0005524|ATP binding|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0007165|signal transduction|IEA; GO:0007600|sensory perception|IEA; GO:0016020|membrane|IEA; GO:0016301|kinase activity|IEA; GO:0016310|phosphorylation|IEA; GO:0016740|transferase activity|IEA; GO:0016772|transferase activity, transferring phosphorus-containing groups|IEA

ACL00001817

unclassified

ACL00001818

Eukaryotic translation initiation factor 6 related cluster

437

1e-91

73% (84/114)

Translation, ribosomal structure and biogenesis

GO:0003743|translation initiation factor activity|IEA; GO:0005634|nucleus|IEA; GO:0005634|nucleus|TAS; GO:0006412|protein biosynthesis|IEA; GO:0006413|translational initiation|IEA

ACL00001819

VATA2

Vacuolar ATP synthase catalytic subunit A, osteoclast isoform related cluster

972

1e-104

72% (181/249)

3.6.3.14

Energy production and conversion

GO:0005524|ATP binding|IEA; GO:0005886|plasma membrane|TAS; GO:0006754|ATP biosynthesis|IEA; GO:0015078|hydrogen ion transporter activity|IEA; GO:0015986|ATP synthesis coupled proton transport|IEA; GO:0015992|proton transport|IEA; GO:0015992|proton transport|TAS; GO:0016469|proton-transporting two-sector ATPase complex|IEA; GO:0016469|proton-transporting two-sector ATPase complex|TAS; GO:0016787|hydrolase activity|IEA; GO:0046933|hydrogen-transporting ATP synthase activity, rotational mechanism|IEA; GO:0046961|hydrogen-transporting ATPase activity, rotational mechanism|IEA

ACL00001820

unclassified

ACL00001821

Cytochrome b5 reductase related cluster

705

4e-73

53% (129/242)

GO:0006118|electron transport|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00001823

Isy1 domain containing protein

488

1e-49

42% (92/218)

ACL00001824

60S acidic ribosomal protein PO related cluster

422

1e-40

49% (82/166)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005634|nucleus|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0007046|ribosome biogenesis|IEA

ACL00001825

Fructose-bisphosphate aldolase related cluster

250

5e-21

55% (61/109)

4.1.2.13

Carbon fixation Fructose and mannose metabolism Glycolysis / Gluconeogenesis Pentose phosphate pathway

GO:0004332|fructose-bisphosphate aldolase activity|IEA; GO:0006096|glycolysis|IEA; GO:0016829|lyase activity|IEA

ACL00001827

unclassified

ACL00001828

Ap2a2

Adapter-related protein complex 2 alpha 2 subunit related cluster

440

4e-43

52% (82/157)

GO:0005198|structural molecule activity|IEA; GO:0005554|molecular_function unknown|ND; GO:0005794|Golgi apparatus|IEA; GO:0005905|coated pit|IEA; GO:0006461|protein complex assembly|IEA; GO:0006810|transport|IEA; GO:0006886|intracellular protein transport|IEA; GO:0006886|intracellular protein transport|NAS; GO:0006897|endocytosis|IEA; GO:0008289|lipid binding|IEA; GO:0015031|protein transport|IEA; GO:0030122|AP-2 adaptor complex|NAS; GO:0030130|clathrin coat of trans-Golgi network vesicle|IEA

ACL00001831

ITPK1

Inositol 1,3,4-trisphosphate 5/6-kinase related cluster

188

8e-14

29% (51/173)

GO:0003824|catalytic activity|TAS; GO:0007165|signal transduction|TAS; GO:0016301|kinase activity|IEA

ACL00001833

Universal stress protein family related cluster

164

1e-10

26% (40/152)

Signal transduction mechanisms

GO:0006950|response to stress|IEA

ACL00001836

Putative serine protease F56F10.1 precursor related cluster

176

3e-12

40% (41/102)

GO:0003824|catalytic activity|IEA; GO:0004252|serine-type endopeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008236|serine-type peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00001838

unclassified

ACL00001839

RHOD domain containing protein

129

2e-09

26% (28/107)

ACL00001840

unclassified

ACL00001842

Unassigned protein

ACL00001843

Unassigned protein

ACL00001844

unclassified

ACL00001845

PGMU

Phosphoglucomutase, cytoplasmic related cluster

65

2e-84

56% (13/23)

5.4.2.2

Carbohydrate transport and metabolism

Galactose metabolism Glycolysis / Gluconeogenesis Pentose phosphate pathway Starch and sucrose metabolism Streptomycin biosynthesis

GO:0000287|magnesium ion binding|IEA; GO:0004614|phosphoglucomutase activity|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0016853|isomerase activity|IEA; GO:0016868|intramolecular transferase activity, phosphotransferases|IEA

ACL00001847

unclassified

ACL00001848

unclassified

ACL00001849

unclassified

ACL00001850

unclassified

ACL00001851

unclassified

ACL00001852

multi-domain protein

135

1e-08

23% (54/229)

ACL00001853

[O] COG0330 Membrane protease subunits, stomatin/prohibitin homologs

717

3e-75

56% (137/243)

Posttranslational modification, protein turnover, chaperones

ACL00001854

unclassified

ACL00001855

multi-domain protein

118

4e-07

28% (29/100)

ACL00001858

DnaJ protein homolog ATJ2 related cluster

381

4e-36

50% (78/155)

Posttranslational modification, protein turnover, chaperones

GO:0006457|protein folding|IEA; GO:0051082|unfolded protein binding|IEA

ACL00001860

unclassified

ACL00001863

unclassified

ACL00001864

unclassified

ACL00001867

unclassified

ACL00001868

unclassified

ACL00001869

unclassified

ACL00001871

unclassified

ACL00001872

unclassified

ACL00001873

unclassified

ACL00001874

unclassified

ACL00001875

unclassified

ACL00001876

unclassified

ACL00001878

unclassified

ACL00001881

unclassified

ACL00001882

unclassified

ACL00001884

Unassigned protein

120

3e-06

66% (24/36)

ACL00001885

unclassified

ACL00001887

CGL

Cystathionine gamma-lyase related cluster

983

1e-105

61% (184/297)

4.4.1.1

Amino acid transport and metabolism

GO:0004123|cystathionine gamma-lyase activity|IDA; GO:0004123|cystathionine gamma-lyase activity|IEA; GO:0006520|amino acid metabolism|IEA; GO:0016829|lyase activity|IEA; GO:0019344|cysteine biosynthesis|IEA

ACL00001888

unclassified

ACL00001889

unclassified

ACL00001890

unclassified

ACL00001891

zgc:66026

N-acylsphingosine amidohydrolase related cluster

121

3e-06

50% (27/54)

GO:0016787|hydrolase activity|IEA

ACL00001893

unclassified

ACL00001894

Csrp3

Cysteine-rich-protein related cluster

167

1e-11

43% (27/62)

GO:0008270|zinc ion binding|IEA

ACL00001895

unclassified

ACL00001896

unclassified

ACL00001897

unclassified

ACL00001898

unclassified

ACL00001899

Unassigned protein

130

2e-07

35% (26/73)

ACL00001900

PUR8

Adenylosuccinate lyase related cluster

133

1e-07

50% (22/44)

4.3.2.2

Nucleotide transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0004018|adenylosuccinate lyase activity|IEA; GO:0006164|purine nucleotide biosynthesis|IEA; GO:0009152|purine ribonucleotide biosynthesis|IEA; GO:0016829|lyase activity|IEA

ACL00001901

unclassified

ACL00001902

Cnn3

Calponin, acidic isoform related cluster

259

5e-22

43% (52/119)

Cytoskeleton

GO:0003779|actin binding|IEA; GO:0003779|actin binding|NAS; GO:0005516|calmodulin binding|IEA; GO:0005516|calmodulin binding|NAS; GO:0005523|tropomyosin binding|NAS; GO:0006939|smooth muscle contraction|IEA; GO:0006939|smooth muscle contraction|NAS; GO:0008372|cellular_component unknown|ND; GO:0030172|troponin C binding|NAS

ACL00001903

unclassified

ACL00001905

unclassified

ACL00001907

unclassified

ACL00001908

Signal recognition particle 54 kDa protein 3 related cluster

177

1e-12

34% (42/123)

Intracellular trafficking, secretion, and vesicular transport

Protein export

GO:0003723|RNA binding|IEA; GO:0005525|GTP binding|IEA; GO:0005786|signal recognition particle (sensu Eukaryota)|IEA; GO:0006605|protein targeting|IEA; GO:0006614|SRP-dependent cotranslational protein-membrane targeting|IEA

ACL00001909

Small ubiquitin-like protein related cluster

175

1e-12

57% (34/59)

Posttranslational modification, protein turnover, chaperones

ACL00001911

unclassified

ACL00001913

unclassified

ACL00001914

unclassified

ACL00001915

unclassified

ACL00001917

unclassified

ACL00001918

unclassified

ACL00001919

unclassified

ACL00001920

Dak2 domain containing protein

107

3e-06

45% (24/53)

ACL00001921

unclassified

ACL00001922

unclassified

ACL00001923

unclassified

ACL00001924

unclassified

ACL00001925

unclassified

ACL00001927

unclassified

ACL00001928

unclassified

ACL00001929

unclassified

ACL00001930

unclassified

ACL00001931

unclassified

ACL00001932

unclassified

ACL00001934

unclassified

ACL00001935

unclassified

ACL00001936

Unknown EST

103

2e-06

52% (21/40)

ACL00001937

COASY

Bifunctional coenzyme A synthase related cluster

197

4e-15

37% (45/121)

2.7.1.24

Pantothenate and CoA biosynthesis

GO:0000004|biological_process unknown|ND; GO:0000166|nucleotide binding|NAS; GO:0003824|catalytic activity|IEA; GO:0004140|dephospho-CoA kinase activity|IEA; GO:0004595|pantetheine-phosphate adenylyltransferase activity|IEA; GO:0005524|ATP binding|IEA; GO:0008372|cellular_component unknown|ND; GO:0015937|coenzyme A biosynthesis|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA; GO:0016779|nucleotidyltransferase activity|IEA

ACL00001939

unclassified

ACL00001940

GTP-binding protein Rac1p related cluster

794

7e-84

77% (145/187)

General function prediction only

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00001944

ADP-ribosylation factor 2 related cluster

452

3e-44

51% (92/180)

ACL00001945

P2X1 receptor related cluster

125

2e-06

36% (29/80)

GO:0004872|receptor activity|IEA; GO:0005216|ion channel activity|IEA; GO:0005524|ATP binding|IEA; GO:0006810|transport|IEA; GO:0006811|ion transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA

ACL00001946

unclassified

ACL00001948

Unassigned protein

207

4e-16

37% (42/112)

ACL00001949

multi-domain protein

108

1e-05

24% (27/110)

ACL00001950

unclassified

ACL00001951

Cyclic GMP-binding protein C related cluster

353

1e-32

44% (75/167)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0004713|protein-tyrosine kinase activity|IEA; GO:0005085|guanyl-nucleotide exchange factor activity|IEA; GO:0005524|ATP binding|IEA; GO:0005525|GTP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0007242|intracellular signaling cascade|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00001952

G3PC

Glyceraldehyde 3-phosphate dehydrogenase, cytosolic related cluster

366

1e-34

68% (71/104)

1.2.1.12

Carbohydrate transport and metabolism

Glycolysis / Gluconeogenesis

GO:0004365|glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity|IEA; GO:0006006|glucose metabolism|IEA; GO:0006096|glycolysis|IEA; GO:0008943|glyceraldehyde-3-phosphate dehydrogenase activity|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00001955

unclassified

ACL00001956

unclassified

ACL00001958

Unassigned protein

ACL00001959

CBS domain containing protein

99

2e-06

36% (17/47)

ACL00001960

unclassified

ACL00001961

Two-component hybrid sensor and regulator related cluster

173

6e-12

51% (35/68)

GO:0000155|two-component sensor molecule activity|IEA; GO:0000156|two-component response regulator activity|IEA; GO:0000160|two-component signal transduction system (phosphorelay)|IEA; GO:0003677|DNA binding|IEA; GO:0004871|signal transducer activity|IEA; GO:0005524|ATP binding|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0007165|signal transduction|IEA; GO:0007600|sensory perception|IEA; GO:0016020|membrane|IEA; GO:0016301|kinase activity|IEA; GO:0016310|phosphorylation|IEA; GO:0016740|transferase activity|IEA; GO:0016772|transferase activity, transferring phosphorus-containing groups|IEA

ACL00001962

Unassigned protein

ACL00001963

Small GTPase rabE related cluster

768

1e-80

75% (141/188)

General function prediction only

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00001968

Amidase related to nicotinamidase related cluster

146

3e-09

33% (38/115)

3.5.1.19

Secondary metabolites biosynthesis, transport and catabolism

Nicotinate and nicotinamide metabolism

GO:0003824|catalytic activity|IEA; GO:0008152|metabolism|IEA; GO:0008908|isochorismatase activity|IEA; GO:0009058|biosynthesis|IEA

ACL00001969

Rac1

Rac related cluster

565

4e-57

53% (104/194)

Cadherin-mediated cell adhesion MAPK signaling pathway Regulation of actin cytoskeleton Toll-like receptor signaling pathway Wnt signaling pathway

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00001970

multi-domain protein

122

3e-07

23% (44/191)

ACL00001971

Intracellular proteinase related cluster

374

2e-35

46% (72/156)

General function prediction only

GO:0016798|hydrolase activity, acting on glycosyl bonds|IEA

ACL00001972

Protein-tyrosine phosphatase-related protein related cluster

246

2e-20

33% (57/169)

Signal transduction mechanisms

GO:0004721|phosphoprotein phosphatase activity|IEA; GO:0006470|protein amino acid dephosphorylation|IEA

ACL00001974

DPM1

Dolichol phosphate mannose synthase related cluster

745

6e-78

61% (143/234)

2.4.1.83

N-Glycan biosynthesis

ACL00001975

mmsB

3-hydroxyacid dehydrogenase related cluster

404

2e-38

33% (94/284)

1.1.1.31

Lipid transport and metabolism

Valine, leucine and isoleucine degradation

ACL00001976

Histone H2A-like protein related cluster

427

3e-41

82% (84/102)

Chromatin structure and dynamics

GO:0000786|nucleosome|IEA; GO:0003677|DNA binding|IEA; GO:0005634|nucleus|IEA; GO:0005694|chromosome|IEA; GO:0006334|nucleosome assembly|IEA; GO:0007001|chromosome organization and biogenesis (sensu Eukaryota)|IEA

ACL00001977

NSR1

Nuclear localization sequence binding protein related cluster

174

2e-11

23% (51/213)

General function prediction only

GO:0000028|ribosomal small subunit assembly and maintenance|TAS; GO:0003677|DNA binding|IEA; GO:0003697|single-stranded DNA binding|IDA; GO:0003723|RNA binding|IEA; GO:0005634|nucleus|IDA; GO:0005634|nucleus|IEA; GO:0005730|nucleolus|TAS; GO:0005739|mitochondrion|IDA; GO:0006364|rRNA processing|IEA; GO:0006364|rRNA processing|TAS

ACL00001978

TP2 domain containing protein

107

8e-06

25% (27/106)

ACL00001979

Polyubiquitin related cluster

1110

1e-120

97% (222/228)

ACL00001982

CG7641

Neurocalcin homolog related cluster

180

1e-12

28% (49/170)

GO:0005509|calcium ion binding|IEA

ACL00001983

HSPC039

HSPC039 protein related cluster

73

6e-07

66% (14/21)

GO:0016021|integral to membrane|IEA

ACL00001990

unclassified

ACL00001992

LOC268449

Ribosomal protein L23a related cluster

509

9e-51

66% (98/147)

Translation, ribosomal structure and biogenesis

GO:0003723|RNA binding|IEA; GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00001994

Rpl27

60S ribosomal protein L27 related cluster

356

3e-33

51% (69/134)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00001995

unclassified

ACL00001996

TRX2

Thioredoxin related cluster

274

5e-24

54% (50/92)

GO:0005489|electron transporter activity|IEA; GO:0006118|electron transport|IEA

ACL00001997

Putative ribosomal protein L26 related cluster

420

1e-40

56% (81/143)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0015934|large ribosomal subunit|IEA

ACL00001998

Thioredoxin peroxidase BgTPx related cluster

691

7e-72

65% (128/194)

GO:0004601|peroxidase activity|IEA

ACL00001999

ATP synthase subunit, probable related cluster

160

8e-11

45% (27/59)

Energy production and conversion

GO:0015986|ATP synthesis coupled proton transport|IEA; GO:0016469|proton-transporting two-sector ATPase complex|IEA; GO:0016787|hydrolase activity|IEA; GO:0046933|hydrogen-transporting ATP synthase activity, rotational mechanism|IEA; GO:0046961|hydrogen-transporting ATPase activity, rotational mechanism|IEA

ACL00002001

Ribosomal protein L37A related cluster

328

3e-30

63% (57/90)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00002006

BolA-like family protein [Arabidopsis thaliana] dbj|BAB09404.1| unnamed protein product [Arabidopsis thaliana] gb|AAM65194.1| unknown [Arabidopsis thaliana] gb|AAO24583.1| At5g09830 [Arabidopsis thaliana]

128

1e-06

42% (25/59)

ACL00002007

DM6 domain containing protein

87

9e-05

29% (18/61)

ACL00002008

Acyl coenzyme A:monoacylglycerol acyltransferase 3 related cluster

199

4e-15

34% (52/150)

Lipid transport and metabolism

GO:0008415|acyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00002009

endopeptidase Clp ATP-binding chain B

ATP-dependent Clp protease, ATP-binding subunit ClpB related cluster

470

1e-46

61% (92/150)

Posttranslational modification, protein turnover, chaperones

GO:0000166|nucleotide binding|IEA; GO:0005515|protein binding|IEA; GO:0005524|ATP binding|IEA; GO:0006457|protein folding|IEA; GO:0006986|response to unfolded protein|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA; GO:0019538|protein metabolism|IEA; GO:0051082|unfolded protein binding|IEA

ACL00002012

multi-domain protein

134

1e-08

22% (35/155)

ACL00002019

Aminopeptidase related cluster

122

3e-06

32% (34/106)

General function prediction only

GO:0004177|aminopeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00002020

Crystallin J1C related cluster

213

9e-17

31% (54/174)

GO:0005212|structural constituent of eye lens|IEA

ACL00002021

Swollenin precursor related cluster

262

2e-22

29% (61/209)

GO:0004553|hydrolase activity, hydrolyzing O-glycosyl compounds|IEA; GO:0005576|extracellular region|IEA; GO:0005975|carbohydrate metabolism|IEA

ACL00002022

Similar to glutamate oxaloacetate transaminase 2 related cluster

855

1e-90

56% (167/293)

GO:0003824|catalytic activity|IEA; GO:0006520|amino acid metabolism|IEA; GO:0008483|transaminase activity|IEA; GO:0009058|biosynthesis|IEA; GO:0016740|transferase activity|IEA

ACL00002023

Putative methyltransferase related cluster

134

4e-07

28% (32/113)

GO:0008168|methyltransferase activity|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00002024

Fatty acid transport protein, putative related cluster

425

2e-41

54% (89/163)

GO:0003824|catalytic activity|IEA; GO:0008152|metabolism|IEA

ACL00002025

unclassified

ACL00002026

KLHDC1

Kelch domain containing protein 1 related cluster

193

2e-14

35% (54/154)

ACL00002027

unclassified

ACL00002028

unclassified

ACL00002029

Clathrin heavy chain related cluster

89

4e-44

72% (16/22)

GO:0005905|coated pit|IEA; GO:0030125|clathrin vesicle coat|IEA

ACL00002030

unclassified

ACL00002031

unclassified

ACL00002032

DUF1421 domain containing protein

111

4e-06

27% (25/90)

ACL00002033

SYW

Tryptophanyl-tRNA synthetase related cluster

456

1e-128

69% (84/121)

6.1.1.2

Translation, ribosomal structure and biogenesis

Aminoacyl-tRNA biosynthesis Tryptophan metabolism

GO:0004812|tRNA ligase activity|IEA; GO:0004830|tryptophan-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006418|tRNA aminoacylation for protein translation|IEA; GO:0006436|tryptophanyl-tRNA aminoacylation|IEA; GO:0016874|ligase activity|IEA

ACL00002034

NCPR

NADPH--cytochrome P450 reductase related cluster

365

3e-34

48% (75/154)

1.6.2.4

Inorganic ion transport and metabolism

GO:0003958|NADPH-hemoprotein reductase activity|IEA; GO:0005489|electron transporter activity|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0006118|electron transport|IEA; GO:0010181|FMN binding|IEA; GO:0016020|membrane|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00002035

MYO3

Inositol-1(or 4)-monophosphatase 3 related cluster

84

4e-15

62% (17/27)

3.1.3.25

Carbohydrate transport and metabolism

GO:0000287|magnesium ion binding|IEA; GO:0004437|inositol or phosphatidylinositol phosphatase activity|IEA; GO:0008934|inositol-1(or 4)-monophosphatase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00002037

Unassigned protein

ACL00002038

BCAT3

Branched-chain amino acid aminotransferase 3, chloroplast precursor related cluster

263

9e-23

44% (47/106)

2.6.1.42

Pantothenate and CoA biosynthesis Valine, leucine and isoleucine biosynthesis Valine, leucine and isoleucine degradation

GO:0003824|catalytic activity|IEA; GO:0004084|branched-chain-amino-acid transaminase activity|IEA; GO:0008152|metabolism|IEA; GO:0008483|transaminase activity|IEA; GO:0009081|branched chain family amino acid metabolism|IEA; GO:0009082|branched chain family amino acid biosynthesis|IEA; GO:0009507|chloroplast|IEA; GO:0016740|transferase activity|IEA

ACL00002039

unclassified

ACL00002040

Unassigned protein

130

2e-07

37% (29/78)

ACL00002041

folP

Dihydropteroate synthase related cluster

274

5e-24

48% (60/124)

2.5.1.15

Coenzyme transport and metabolism

Folate biosynthesis

GO:0004156|dihydropteroate synthase activity|IEA; GO:0009396|folic acid and derivative biosynthesis|IEA; GO:0016740|transferase activity|IEA

ACL00002042

T19J18.12; calcium-dependent protein kinase, putative / CDPK, putative

136

3e-08

32% (34/106)

ACL00002043

Prkcd

Protein kinase C, delta type related cluster

194

2e-14

36% (45/122)

Calcium signaling pathway MAPK signaling pathway Phosphatidylinositol signaling system Wnt signaling pathway

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0006917|induction of apoptosis|IDA; GO:0007242|intracellular signaling cascade|IDA; GO:0007242|intracellular signaling cascade|IEA; GO:0016020|membrane|IEA; GO:0016740|transferase activity|IEA; GO:0019992|diacylglycerol binding|IEA

ACL00002044

multi-domain protein

113

3e-06

25% (61/242)

ACL00002045

unclassified

ACL00002046

unclassified

ACL00002047

Twinkle related cluster

356

2e-33

45% (78/172)

GO:0003678|DNA helicase activity|IDA; GO:0005739|mitochondrion|IDA; GO:0006268|DNA unwinding|IDA

ACL00002048

Lipe

Hormone-sensitive lipase related cluster

171

4e-12

48% (35/72)

3.1.1.-

Lipid transport and metabolism

Alkaloid biosynthesis II Butanoate metabolism

GO:0003824|catalytic activity|IEA; GO:0004806|triacylglycerol lipase activity|IEA; GO:0008152|metabolism|IEA; GO:0016787|hydrolase activity|IEA

ACL00002049

unclassified

ACL00002050

unclassified

ACL00002051

DUF1431 domain containing protein

111

6e-06

27% (30/110)

ACL00002052

heme (2M975) [Caenorhabditis elegans]

123

4e-06

52% (24/46)

2.5.1.-

Oxidative phosphorylation

ACL00002053

unclassified

ACL00002054

unclassified

ACL00002055

Ribonuclease T2 related cluster

348

6e-32

31% (69/218)

3.1.27.1

Translation, ribosomal structure and biogenesis

GO:0003723|RNA binding|IEA; GO:0004521|endoribonuclease activity|IEA

ACL00002056

T22D6.120; ribosomal protein L7Ae family

227

9e-19

46% (47/101)

Translation, ribosomal structure and biogenesis

ACL00002057

unclassified

ACL00002058

Tnxb

Tenascin X precursor related cluster

215

7e-17

42% (43/101)

GO:0005515|protein binding|IEA; GO:0005578|extracellular matrix (sensu Metazoa)|IEA; GO:0005578|extracellular matrix (sensu Metazoa)|NAS; GO:0007155|cell adhesion|IEA; GO:0007160|cell-matrix adhesion|NAS

ACL00002059

unclassified

ACL00002060

GTP-binding protein YPTC5 related cluster

485

7e-48

51% (98/191)

General function prediction only

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00002061

unclassified

ACL00002062

STOML2

Stomatin-like protein related cluster

396

8e-38

52% (73/138)

Posttranslational modification, protein turnover, chaperones

GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA

ACL00002063

multi-domain protein

112

7e-06

24% (73/304)

ACL00002065

SYQ

Probable glutaminyl-tRNA synthetase related cluster

310

5e-28

50% (64/126)

6.1.1.18

Translation, ribosomal structure and biogenesis

Aminoacyl-tRNA biosynthesis Glutamate metabolism

GO:0004812|tRNA ligase activity|IEA; GO:0004818|glutamate-tRNA ligase activity|IEA; GO:0004819|glutamine-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006418|tRNA aminoacylation for protein translation|IEA; GO:0006424|glutamyl-tRNA aminoacylation|IEA; GO:0016874|ligase activity|IEA

ACL00002066

APH domain containing protein

166

2e-12

26% (44/164)

ACL00002067

Constitutive triple response 1-like protein kinase related cluster

286

4e-25

37% (59/158)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

ACL00002068

SYE1

Glutamyl-tRNA synthetase 1 related cluster

142

1e-08

30% (39/129)

6.1.1.17

Aminoacyl-tRNA biosynthesis Glutamate metabolism Porphyrin and chlorophyll metabolism

GO:0004812|tRNA ligase activity|IEA; GO:0004818|glutamate-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0005737|cytoplasm|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006418|tRNA aminoacylation for protein translation|IEA; GO:0006424|glutamyl-tRNA aminoacylation|IEA; GO:0016874|ligase activity|IEA

ACL00002069

unclassified

ACL00002071

Unassigned protein

174

9e-12

31% (50/157)

ACL00002072

Ras-related protein Rab-18 related cluster

322

1e-29

59% (61/102)

GO:0003924|GTPase activity|NAS; GO:0005525|GTP binding|IEA; GO:0006897|endocytosis|NAS; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0007264|small GTPase mediated signal transduction|NAS; GO:0008372|cellular_component unknown|ND; GO:0015031|protein transport|IEA

ACL00002073

unclassified

ACL00002074

unclassified

ACL00002075

Unassigned protein

ACL00002076

Unassigned protein

131

1e-07

49% (28/57)

ACL00002077

Putative cyclophilin related cluster

355

2e-33

77% (65/84)

5.2.1.8

Posttranslational modification, protein turnover, chaperones

GO:0003755|peptidyl-prolyl cis-trans isomerase activity|IEA; GO:0006457|protein folding|IEA; GO:0016853|isomerase activity|IEA

ACL00002078

HEM6

Coproporphyrinogen III oxidase, aerobic related cluster

682

1e-70

44% (140/318)

1.3.3.3

Coenzyme transport and metabolism

GO:0004109|coproporphyrinogen oxidase activity|IEA; GO:0006779|porphyrin biosynthesis|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00002079

mvp

Major vault protein alpha related cluster

508

7e-51

59% (108/181)

GO:0030529|ribonucleoprotein complex|IEA

ACL00002080

Peroxidase ppod11 related cluster

144

1e-08

39% (43/108)

GO:0004601|peroxidase activity|IEA

ACL00002081

(S)-adenosyl-L-methionine:delta 24-sterol methyltransferase related cluster

327

3e-82

58% (61/104)

2.1.1.41

GO:0008168|methyltransferase activity|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00002082

unclassified

ACL00002084

unclassified

ACL00002085

Similar to Brassica rapa subsp. pekinensis (Chinese cabbage) (Celery cabbage). Aminoalcoholphosphotransferase related cluster

251

6e-21

30% (54/179)

GO:0005198|structural molecule activity|IEA

ACL00002086

unclassified

ACL00002087

KCC1A

Calcium/calmodulin-dependent protein kinase type I related cluster

646

1e-66

57% (132/230)

2.7.1.123

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0004685|calcium- and calmodulin-dependent protein kinase activity|IEA; GO:0004685|calcium- and calmodulin-dependent protein kinase activity|TAS; GO:0005516|calmodulin binding|IEA; GO:0005524|ATP binding|IEA; GO:0005634|nucleus|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0006468|protein amino acid phosphorylation|TAS; GO:0007165|signal transduction|TAS; GO:0007399|neurogenesis|IEA; GO:0016740|transferase activity|IEA

ACL00002088

unclassified

ACL00002091

Putative nicotinate phosphoribosyltransferase related cluster

270

2e-23

65% (49/75)

Coenzyme transport and metabolism

GO:0004516|nicotinate phosphoribosyltransferase activity|IEA; GO:0016740|transferase activity|IEA; GO:0016757|transferase activity, transferring glycosyl groups|IEA; GO:0019363|pyridine nucleotide biosynthesis|IEA

ACL00002092

Trehalose-6-phosphate phosphatase related cluster

406

6e-39

39% (84/211)

Carbohydrate transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0003825|alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity|IEA; GO:0004805|trehalose-phosphatase activity|IEA; GO:0005992|trehalose biosynthesis|IEA; GO:0008152|metabolism|IEA; GO:0016787|hydrolase activity|IEA

ACL00002093

Unassigned protein

120

7e-06

34% (25/73)

ACL00002094

Tymo_45kd_70kd domain containing protein

119

6e-07

24% (49/203)

ACL00002095

DSPc domain containing protein

104

7e-07

38% (15/39)

ACL00002096

SYI

Isoleucyl-tRNA synthetase, cytoplasmic related cluster

242

8e-20

33% (58/175)

6.1.1.5

Translation, ribosomal structure and biogenesis

GO:0004812|tRNA ligase activity|IEA; GO:0004822|isoleucine-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0005625|soluble fraction|TAS; GO:0005737|cytoplasm|TAS; GO:0006412|protein biosynthesis|IEA; GO:0006412|protein biosynthesis|NR; GO:0006418|tRNA aminoacylation for protein translation|IEA; GO:0006428|isoleucyl-tRNA aminoacylation|IEA; GO:0016874|ligase activity|IEA

ACL00002097

multi-domain protein

145

1e-09

24% (88/362)

ACL00002098

INO1

Inositol-3-phosphate synthase related cluster

514

2e-51

67% (102/151)

5.5.1.4

Lipid transport and metabolism

GO:0004512|inositol-3-phosphate synthase activity|IEA; GO:0006021|myo-inositol biosynthesis|IEA; GO:0008654|phospholipid biosynthesis|IEA; GO:0016853|isomerase activity|IEA

ACL00002099

Putative 5-3 exoribonuclease related cluster

292

1e-25

43% (61/140)

GO:0003676|nucleic acid binding|IEA; GO:0004527|exonuclease activity|IEA; GO:0005634|nucleus|IEA

ACL00002100

Unknown EST

122

9e-07

53% (22/41)

ACL00002102

AKR7A3

Aflatoxin B1 aldehyde reductase member 3 related cluster

287

9e-56

45% (67/147)

1.-.-.-

Energy production and conversion

GO:0004033|aldo-keto reductase activity|TAS; GO:0005489|electron transporter activity|TAS; GO:0005829|cytosol|TAS; GO:0006081|aldehyde metabolism|TAS; GO:0016491|oxidoreductase activity|IEA

ACL00002103

Unknown EST

164

3e-13

37% (30/81)

ACL00002104

ProSAAS domain containing protein

108

7e-06

29% (33/113)

ACL00002105

IOD1

Type I iodothyronine deiodinase related cluster

183

2e-12

34% (40/115)

1.97.1.10

GO:0004800|thyroxine 5'-deiodinase activity|IEA; GO:0005615|extracellular space|TAS; GO:0016021|integral to membrane|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00002106

Probable mitochondrial import receptor subunit TOM40 homolog related cluster

180

2e-12

32% (72/223)

GO:0005739|mitochondrion|IEA; GO:0005741|mitochondrial outer membrane|IEA; GO:0006810|transport|IEA; GO:0006820|anion transport|IEA; GO:0006886|intracellular protein transport|IEA; GO:0008308|voltage-gated ion-selective channel activity|IEA; GO:0015031|protein transport|IEA; GO:0015450|protein translocase activity|IEA; GO:0016021|integral to membrane|IEA; GO:0019867|outer membrane|IEA

ACL00002107

UBP15

Ubiquitin carboxyl-terminal hydrolase 15 related cluster

153

5e-10

54% (25/46)

3.1.2.15

Posttranslational modification, protein turnover, chaperones

GO:0004197|cysteine-type endopeptidase activity|IEA; GO:0004197|cysteine-type endopeptidase activity|TAS; GO:0004221|ubiquitin thiolesterase activity|IEA; GO:0004843|ubiquitin-specific protease activity|TAS; GO:0006511|ubiquitin-dependent protein catabolism|IEA; GO:0006512|ubiquitin cycle|IEA; GO:0008234|cysteine-type peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00002108

[K] COG5033 Transcription initiation factor IIF, auxiliary subunit

122

1e-06

32% (29/88)

Transcription

ACL00002109

unclassified

ACL00002111

unclassified

ACL00002112

Unknown EST

145

8e-10

70% (29/41)

ACL00002113

Putative Nudix hydrolase lin0387 related cluster

168

1e-11

34% (42/123)

GO:0004452|isopentenyl-diphosphate delta-isomerase activity|IEA; GO:0008299|isoprenoid biosynthesis|IEA; GO:0016787|hydrolase activity|IEA

ACL00002114

unclassified

ACL00002115

CTP synthase like protein related cluster

579

4e-59

61% (113/184)

6.3.4.2

Nucleotide transport and metabolism

Pyrimidine metabolism

GO:0003824|catalytic activity|IEA; GO:0003883|CTP synthase activity|IEA; GO:0006221|pyrimidine nucleotide biosynthesis|IEA; GO:0016874|ligase activity|IEA

ACL00002116

unclassified

ACL00002117

Filamin/ABP280 repeat family member (XK45) [Caenorhabditis elegans] gb|AAN60531.1| Hypothetical protein C23F12.1a [Caenorhabditis elegans]

129

1e-06

42% (28/66)

ACL00002118

Small nuclear ribonucleoprotein homolog related cluster

335

4e-31

80% (66/82)

Transcription

GO:0005634|nucleus|IEA; GO:0005732|small nucleolar ribonucleoprotein complex|IEA; GO:0006397|mRNA processing|IEA; GO:0008248|pre-mRNA splicing factor activity|IEA; GO:0019013|viral nucleocapsid|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00002119

SYM

Probable methionyl-tRNA synthetase related cluster

226

7e-18

40% (60/150)

6.1.1.10

GO:0000049|tRNA binding|IEA; GO:0003723|RNA binding|IEA; GO:0004812|tRNA ligase activity|IEA; GO:0004825|methionine-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006418|tRNA aminoacylation for protein translation|IEA; GO:0006431|methionyl-tRNA aminoacylation|IEA; GO:0016874|ligase activity|IEA

ACL00002120

Putative carrier protein related cluster

203

2e-15

30% (57/188)

GO:0005215|transporter activity|IEA; GO:0005488|binding|IEA; GO:0005743|mitochondrial inner membrane|IEA; GO:0006810|transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA

ACL00002121

unclassified

ACL00002122

HAD superfamily hydrolase related cluster

131

6e-07

22% (53/232)

GO:0003824|catalytic activity|IEA; GO:0008152|metabolism|IEA; GO:0016787|hydrolase activity|IEA

ACL00002123

Fts

Fused TOES related cluster

299

2e-26

35% (74/210)

GO:0004840|ubiquitin conjugating enzyme activity|IEA; GO:0006464|protein modification|IEA; GO:0006512|ubiquitin cycle|IEA; GO:0006915|apoptosis|IEA; GO:0016020|membrane|IEA

ACL00002124

unclassified

ACL00002125

Putative WD-40 repeat-protein related cluster

129

5e-07

40% (28/70)

General function prediction only

GO:0004871|signal transducer activity|IEA; GO:0005834|heterotrimeric G-protein complex|IEA; GO:0007186|G-protein coupled receptor protein signaling pathway|IEA

ACL00002126

GRIM-19 domain containing protein

123

2e-07

24% (27/111)

ACL00002127

unclassified

ACL00002128

Unknown EST

118

2e-06

43% (22/51)

ACL00002129

Unassigned protein

ACL00002130

Unassigned protein

148

5e-09

34% (32/94)

ACL00002131

unclassified

ACL00002132

Cell division control protein 45 homolog related cluster

200

2e-15

35% (48/135)

GO:0000074|regulation of cell cycle|IEA; GO:0005634|nucleus|IEA; GO:0005656|pre-replicative complex|IDA; GO:0006260|DNA replication|IEA; GO:0006270|DNA replication initiation|IEA; GO:0007049|cell cycle|IEA

ACL00002133

unclassified

ACL00002134

maf

Maf-like protein CPE2145 related cluster

132

2e-07

66% (24/36)

GO:0005554|molecular_function unknown|IEA

ACL00002135

unclassified

ACL00002136

unclassified

ACL00002137

Unassigned protein

ACL00002138

Putative glutamyl-tRNA synthetase related cluster

353

6e-33

50% (70/139)

Translation, ribosomal structure and biogenesis

GO:0004812|tRNA ligase activity|IEA; GO:0004818|glutamate-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0005737|cytoplasm|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006418|tRNA aminoacylation for protein translation|IEA; GO:0006424|glutamyl-tRNA aminoacylation|IEA; GO:0016874|ligase activity|IEA

ACL00002139

unclassified

ACL00002141

unclassified

ACL00002142

Coq6

Ubiquinone biosynthesis monooxgenase COQ6 related cluster

329

5e-30

53% (64/120)

1,4-Dichlorobenzene degradation Androgen and estrogen metabolism Bile acid biosynthesis Biosynthesis of steroids Histidine metabolism Limonene and pinene degradation Methane metabolism Nitrobenzene degradation Phenylalanine metabolism Stilbene, coumarine and lignin biosynthesis Styrene degradation Tryptophan metabolism Tyrosine metabolism Ubiquinone biosynthesis gamma-Hexachlorocyclohexane degradation

GO:0004497|monooxygenase activity|IEA; GO:0005615|extracellular space|TAS; GO:0006118|electron transport|IEA; GO:0006725|aromatic compound metabolism|IEA; GO:0006744|ubiquinone biosynthesis|IEA; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00002145

50S ribosomal protein L24 related cluster

56

2e-21

50% (9/18)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0030529|ribonucleoprotein complex|IEA

ACL00002146

Clathrin assembly protein AP19, small subunit related cluster

149

4e-34

59% (25/42)

Intracellular trafficking, secretion, and vesicular transport

GO:0006886|intracellular protein transport|IEA; GO:0030125|clathrin vesicle coat|IEA

ACL00002147

multi-domain protein

159

7e-12

49% (33/67)

ACL00002148

unclassified

ACL00002149

multi-domain protein

129

2e-08

51% (25/49)

ACL00002150

Unassigned protein

ACL00002151

Unassigned protein

ACL00002152

unclassified

ACL00002153

unclassified

ACL00002154

unclassified

ACL00002155

GLA protein related cluster

150

2e-09

34% (43/126)

GO:0008080|N-acetyltransferase activity|IEA

ACL00002156

Ras suppressor protein 1 related cluster

135

6e-08

42% (26/61)

GO:0007165|signal transduction|TAS

ACL00002157

unclassified

ACL00002158

Calmodulin related cluster

236

1e-19

39% (42/107)

Phosphatidylinositol signaling system

GO:0005509|calcium ion binding|IEA

ACL00002159

unclassified

ACL00002160

Lipoate protein ligase-like protein related cluster

277

2e-24

46% (61/130)

6.-.-.-

Coenzyme transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0006464|protein modification|IEA; GO:0016874|ligase activity|IEA

ACL00002161

unclassified

ACL00002162

unclassified

ACL00002164

MOSC domain protein related cluster

385

3e-36

34% (99/289)

ACL00002165

unclassified

ACL00002166

Unknown EST

57

1e-21

47% (10/21)

ACL00002167

Adaptor-related protein complex 1, mu 1 subunit related cluster

514

1e-51

60% (97/161)

GO:0005794|Golgi apparatus|IEA; GO:0005905|coated pit|IEA; GO:0006810|transport|IEA; GO:0006886|intracellular protein transport|IEA; GO:0006897|endocytosis|IEA; GO:0015031|protein transport|IEA; GO:0030125|clathrin vesicle coat|IEA

ACL00002169

Unassigned protein

ACL00002170

multi-domain protein

128

5e-08

20% (45/216)

ACL00002171

Acid phosphatase related cluster

361

2e-33

42% (73/170)

GO:0003824|catalytic activity|IEA; GO:0008152|metabolism|IEA; GO:0016787|hydrolase activity|IEA

ACL00002172

Splicing variant of retinal degeneration B beta related cluster

193

5e-14

36% (42/115)

GO:0005622|intracellular|IEA; GO:0006810|transport|IEA

ACL00002173

unclassified

ACL00002174

unclassified

ACL00002175

[R] COG1574 Predicted metal-dependent hydrolase with the TIM-barrel fold

268

1e-23

42% (56/131)

General function prediction only

ACL00002176

Putative ankyrin repeat-containing protein related cluster

166

2e-11

48% (42/87)

General function prediction only

ACL00002177

unclassified

ACL00002178

unclassified

ACL00002179

unclassified

ACL00002180

unclassified

ACL00002181

CG3683

CG3683; CG3683 gene product from transcript CG3683-RA [EC:1.6.99.3] [KO:K00356]

138

7e-08

30% (29/95)

1.6.99.3

Oxidative phosphorylation

ACL00002182

phzF

Phenazine biosynthesis protein related cluster

260

4e-22

37% (62/167)

GO:0003824|catalytic activity|IEA; GO:0009058|biosynthesis|IEA

ACL00002183

MGC4399

Mitochondrial carrier protein related cluster

262

3e-22

38% (63/162)

GO:0005488|binding|IEA; GO:0005743|mitochondrial inner membrane|IEA; GO:0006810|transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA

ACL00002184

unclassified

ACL00002185

unclassified

ACL00002186

CTP:phosphorylcholine cytidylyltransferase related cluster

201

2e-15

43% (56/130)

GO:0004105|choline-phosphate cytidylyltransferase activity|IEA; GO:0009058|biosynthesis|IEA; GO:0016740|transferase activity|IEA; GO:0016779|nucleotidyltransferase activity|IEA

ACL00002187

Unknown EST

145

3e-10

100% (24/24)

ACL00002188

SRM

Spermidine synthase related cluster

125

5e-06

57% (23/40)

2.5.1.16

Amino acid transport and metabolism

Arginine and proline metabolism Urea cycle and metabolism of amino groups beta-Alanine metabolism

GO:0003824|catalytic activity|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00002189

5NTC

Cytosolic purine 5'-nucleotidase related cluster

220

2e-17

41% (44/105)

3.1.3.5

GO:0003824|catalytic activity|IEA; GO:0005829|cytosol|NR; GO:0008253|5'-nucleotidase activity|IEA; GO:0008253|5'-nucleotidase activity|TAS; GO:0016787|hydrolase activity|IEA

ACL00002190

Bmi1 upstream related cluster

142

1e-08

29% (35/118)

ACL00002191

Luminal binding protein precursor related cluster

407

1e-124

51% (75/145)

GO:0005524|ATP binding|IEA; GO:0005783|endoplasmic reticulum|IEA

ACL00002192

unclassified

ACL00002194

unclassified

ACL00002195

KIAA1219

Protein KIAA1219 related cluster

165

2e-11

44% (41/93)

GO:0005096|GTPase activator activity|IEA

ACL00002196

p44S10

26S proteasome non-ATPase regulatory subunit 6 related cluster

908

7e-97

59% (176/298)

Posttranslational modification, protein turnover, chaperones

Proteasome

GO:0000502|proteasome complex (sensu Eukaryota)|NAS; GO:0005488|binding|IEA; GO:0005829|cytosol|IEA; GO:0006510|ATP-dependent proteolysis|NAS; GO:0016887|ATPase activity|NAS

ACL00002197

Complex1_LYR domain containing protein

126

8e-08

38% (23/59)

ACL00002198

unclassified

ACL00002199

unclassified

ACL00002200

unclassified

ACL00002201

unclassified

ACL00002204

Ribosome biogenesis protein Brix related cluster

175

7e-40

50% (38/75)

Translation, ribosomal structure and biogenesis

GO:0005634|nucleus|IEA; GO:0007046|ribosome biogenesis|IEA

ACL00002206

unclassified

ACL00002207

fixL

Sensor protein fixL related cluster

263

4e-22

34% (57/164)

GO:0000155|two-component sensor molecule activity|IEA; GO:0000160|two-component signal transduction system (phosphorelay)|IEA; GO:0004871|signal transducer activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0007165|signal transduction|IEA; GO:0007600|sensory perception|IEA; GO:0009399|nitrogen fixation|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016301|kinase activity|IEA; GO:0016310|phosphorylation|IEA; GO:0016740|transferase activity|IEA; GO:0016772|transferase activity, transferring phosphorus-containing groups|IEA; GO:0019866|inner membrane|IEA

ACL00002209

Endopeptidase 24.16 related cluster

528

4e-53

59% (108/183)

GO:0004222|metalloendopeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008237|metallopeptidase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00002210

CSK

Tyrosine-protein kinase CSK related cluster

143

2e-08

42% (35/83)

2.7.1.112

Integrin-mediated cell adhesion Regulation of actin cytoskeleton

GO:0000074|regulation of cell cycle|TAS; GO:0004672|protein kinase activity|IEA; GO:0004713|protein-tyrosine kinase activity|IEA; GO:0004713|protein-tyrosine kinase activity|TAS; GO:0005524|ATP binding|IEA; GO:0005737|cytoplasm|NR; GO:0006468|protein amino acid phosphorylation|IEA; GO:0006468|protein amino acid phosphorylation|TAS; GO:0007242|intracellular signaling cascade|IEA; GO:0008022|protein C-terminus binding|TAS; GO:0016740|transferase activity|IEA

ACL00002211

unclassified

ACL00002213

unclassified

ACL00002214

Phosphoglucose isomerase related cluster

410

8e-40

68% (77/112)

Carbohydrate transport and metabolism

GO:0004347|glucose-6-phosphate isomerase activity|IEA; GO:0006094|gluconeogenesis|IEA; GO:0006096|glycolysis|IEA; GO:0016853|isomerase activity|IEA

ACL00002215

unclassified

ACL00002216

NUDT5

ADP-sugar pyrophosphatase related cluster

325

8e-30

40% (62/152)

3.6.1.13

GO:0000287|magnesium ion binding|IEA; GO:0005515|protein binding|NAS; GO:0005622|intracellular|NAS; GO:0016787|hydrolase activity|IEA; GO:0019144|ADP-sugar diphosphatase activity|IDA; GO:0019303|D-ribose catabolism|NAS

ACL00002217

unclassified

ACL00002218

unclassified

ACL00002220

unclassified

ACL00002221

unclassified

ACL00002223

unclassified

ACL00002224

unclassified

ACL00002225

RB-binding protein related cluster

145

6e-09

43% (29/66)

GO:0003677|DNA binding|IEA; GO:0005622|intracellular|IEA; GO:0005634|nucleus|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA

ACL00002226

Cytochrome b5 reductase isoform II related cluster

286

2e-25

38% (58/151)

1.6.2.2

Aminosugars metabolism

GO:0006118|electron transport|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00002227

unclassified

ACL00002228

Predicted flavin-nucleotide-binding protein related cluster

153

5e-10

34% (31/90)

General function prediction only

ACL00002229

multi-domain protein

116

1e-06

19% (38/193)

ACL00002230

Similar to seryl-tRNA synthetase, cytoplasmic related cluster

357

4e-33

38% (100/262)

Translation, ribosomal structure and biogenesis

GO:0000160|two-component signal transduction system (phosphorelay)|IEA; GO:0003677|DNA binding|IEA; GO:0005525|GTP binding|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006886|intracellular protein transport|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00002232

unclassified

ACL00002233

putative S-adenosyl methionine dependent methyltransferase like protein

331

2e-30

43% (73/167)

ACL00002235

unclassified

ACL00002236

Herpes_gp2 domain containing protein

122

3e-07

24% (41/165)

ACL00002237

Cwf15 / Cwc15 cell cycle control family protein [Arabidopsis thaliana] dbj|BAB01412.1| unnamed protein product [Arabidopsis thaliana]

184

3e-13

64% (36/56)

ACL00002238

idnO1

Putative 5-keto-D-gluconate 5-reductase protein related cluster

181

3e-13

47% (38/80)

1.1.1.69

GO:0008152|metabolism|IEA; GO:0008874|gluconate 5-dehydrogenase activity|IEA; GO:0016491|oxidoreductase activity|IEA

ACL00002239

Cytosol aminopeptidase, putative related cluster

66

2e-59

40% (19/47)

3.4.11.1

Amino acid transport and metabolism

GO:0004177|aminopeptidase activity|IEA; GO:0004178|leucyl aminopeptidase activity|IEA; GO:0005622|intracellular|IEA; GO:0005737|cytoplasm|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0019538|protein metabolism|IEA; GO:0030145|manganese ion binding|IEA

ACL00002240

unclassified

ACL00002241

ITSN2

Intersectin 2 related cluster

160

8e-11

53% (26/49)

GO:0005070|SH3/SH2 adaptor protein activity|TAS; GO:0005509|calcium ion binding|IEA; GO:0006897|endocytosis|IEA

ACL00002242

multi-domain protein

94

1e-05

29% (22/74)

ACL00002243

yfmJ

YFMJ protein related cluster

470

2e-46

47% (98/208)

GO:0004024|alcohol dehydrogenase activity, zinc-dependent|IEA; GO:0008270|zinc ion binding|IEA

ACL00002244

unclassified

ACL00002246

BCS1L

Mitochondrial chaperone BCS1 related cluster

403

2e-38

45% (91/198)

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0005739|mitochondrion|IEA; GO:0006457|protein folding|IEA; GO:0016021|integral to membrane|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA; GO:0051082|unfolded protein binding|IEA

ACL00002247

unclassified

ACL00002248

unclassified

ACL00002249

Isochorismatase related cluster

281

9e-25

45% (55/121)

GO:0003824|catalytic activity|IEA; GO:0008152|metabolism|IEA; GO:0008908|isochorismatase activity|IEA; GO:0016787|hydrolase activity|IEA

ACL00002251

unclassified

ACL00002253

unclassified

ACL00002254

Unknown EST

108

8e-06

46% (23/49)

ACL00002255

ADP,ATP carrier protein related cluster

723

2e-75

48% (142/292)

GO:0005215|transporter activity|IEA; GO:0005471|ATP:ADP antiporter activity|IGI; GO:0005488|binding|IEA; GO:0005739|mitochondrion|IEA; GO:0005743|mitochondrial inner membrane|IEA; GO:0005743|mitochondrial inner membrane|IGI; GO:0006810|transport|IEA; GO:0006839|mitochondrial transport|IGI; GO:0009060|aerobic respiration|IGI; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0019866|inner membrane|IEA

ACL00002256

unclassified

ACL00002257

unclassified

ACL00002258

Dimethyladenosine transferase related cluster

686

2e-71

68% (127/186)

Translation, ribosomal structure and biogenesis

GO:0000154|rRNA modification|IEA; GO:0000179|rRNA (adenine-N6,N6-)-dimethyltransferase activity|IEA; GO:0006364|rRNA processing|IEA; GO:0008168|methyltransferase activity|IEA; GO:0008649|rRNA methyltransferase activity|IEA; GO:0008757|S-adenosylmethionine-dependent methyltransferase activity|IEA; GO:0016740|transferase activity|IEA

ACL00002259

unclassified

ACL00002260

TPP1

Trehalose-phosphatase related cluster

313

6e-28

31% (82/262)

3.1.3.12

Carbohydrate transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0003825|alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity|IEA; GO:0004805|trehalose-phosphatase activity|IEA; GO:0005992|trehalose biosynthesis|IEA; GO:0008152|metabolism|IEA; GO:0016787|hydrolase activity|IEA

ACL00002262

unclassified

ACL00002263

Aspartyl aminopeptidase-like protein related cluster

425

1e-41

60% (81/135)

3.4.11.21

Amino acid transport and metabolism

GO:0004177|aminopeptidase activity|IEA; GO:0004250|aminopeptidase I activity|IEA; GO:0005773|vacuole|IEA; GO:0006508|proteolysis and peptidolysis|IEA

ACL00002264

unclassified

ACL00002265

unclassified

ACL00002266

Sas10_Utp3 domain containing protein

116

6e-07

38% (21/55)

ACL00002267

Ribosomal protein L34-like protein related cluster

91

4e-17

51% (14/27)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00002268

unclassified

ACL00002269

tRNA_m1G_MT_9 domain containing protein

115

1e-06

25% (18/70)

ACL00002270

unclassified

ACL00002271

unclassified

ACL00002272

Unassigned protein

ACL00002273

unclassified

ACL00002274

unclassified

ACL00002275

TTL domain containing protein

171

4e-13

24% (29/119)

ACL00002276

CG3057

Congested-like trachea protein related cluster

279

2e-24

57% (54/94)

GO:0005215|transporter activity|IEA; GO:0005215|transporter activity|ISS; GO:0005488|binding|IEA; GO:0005739|mitochondrion|IEA; GO:0005740|mitochondrial membrane|ISS; GO:0005743|mitochondrial inner membrane|IEA; GO:0006810|transport|IEA; GO:0006839|mitochondrial transport|ISS; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0019866|inner membrane|IEA

ACL00002277

multi-domain protein

122

3e-07

33% (32/96)

ACL00002278

unclassified

ACL00002279

Histone H1 related cluster

155

3e-10

49% (40/81)

GO:0000786|nucleosome|IEA; GO:0003677|DNA binding|IEA; GO:0005516|calmodulin binding|IEA; GO:0005634|nucleus|IEA; GO:0005694|chromosome|IEA; GO:0006334|nucleosome assembly|IEA; GO:0007001|chromosome organization and biogenesis (sensu Eukaryota)|IEA

ACL00002280

Epithelial protein lost in neoplasm related cluster

147

3e-09

51% (29/56)

GO:0008270|zinc ion binding|IEA

ACL00002282

Rpl8

Ribosomal protein L related cluster

151

2e-73

81% (27/33)

Translation, ribosomal structure and biogenesis

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

ACL00002284

Rps11

40S ribosomal protein S11 related cluster

241

5e-20

69% (47/68)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003723|RNA binding|TAS; GO:0003735|structural constituent of ribosome|TAS; GO:0005840|ribosome|TAS; GO:0006412|protein biosynthesis|TAS

ACL00002286

Polyubiquitin related cluster

980

1e-105

97% (195/199)

ACL00002291

unclassified

ACL00002294

inosine-uridine preferring nucleoside hydrolase family protein [Arabidopsis thaliana] gb|AAL84950.1| AT5g18860/F17K4_110 [Arabidopsis thaliana] gb|AAM91461.1| AT5g18860/F17K4_110 [Arabidopsis thaliana]

129

1e-06

37% (34/91)

ACL00002295

unclassified

ACL00002296

unclassified

ACL00002297

CG3320

Ras-related protein Rab-1A related cluster

643

3e-66

60% (120/198)

GO:0005525|GTP binding|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0005794|Golgi apparatus|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00002298

CG13852

CG13852; CG13852 gene product

166

1e-11

69% (29/42)

ACL00002299

Lysozyme II precursor related cluster

445

2e-43

46% (96/205)

ACL00002300

Major vault protein alpha related cluster

940

1e-100

73% (185/253)

GO:0030529|ribonucleoprotein complex|IEA

ACL00002305

LYSX

Lysozyme X precursor related cluster

118

8e-06

36% (32/87)

3.2.1.17

GO:0003796|lysozyme activity|IEA; GO:0003824|catalytic activity|IEA; GO:0005576|extracellular region|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0016787|hydrolase activity|IEA; GO:0016798|hydrolase activity, acting on glycosyl bonds|IEA; GO:0016998|cell wall catabolism|IEA; GO:0019835|cytolysis|IEA; GO:0042742|defense response to bacteria|IEA

ACL00002306

DUF393 domain containing protein

159

1e-11

31% (28/88)

ACL00002307

PPCM

Phosphoenolpyruvate carboxykinase, mitochondrial precursor [GTP] related cluster

525

1e-52

46% (102/220)

4.1.1.32

Energy production and conversion

Citrate cycle (TCA cycle) Pyruvate metabolism

GO:0004611|phosphoenolpyruvate carboxykinase activity|IEA; GO:0004611|phosphoenolpyruvate carboxykinase activity|TAS; GO:0004613|phosphoenolpyruvate carboxykinase (GTP) activity|IEA; GO:0005525|GTP binding|IEA; GO:0005739|mitochondrion|IEA; GO:0005739|mitochondrion|TAS; GO:0006006|glucose metabolism|NR; GO:0006094|gluconeogenesis|IEA; GO:0016829|lyase activity|IEA; GO:0016831|carboxy-lyase activity|IEA; GO:0030145|manganese ion binding|IEA

ACL00002308

crt-1

Calreticulin precursor related cluster

226

3e-18

58% (44/75)

GO:0005509|calcium ion binding|IEA; GO:0005529|sugar binding|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0006457|protein folding|IEA; GO:0051082|unfolded protein binding|IEA

ACL00002311

BCAS2

BCAS2; breast carcinoma amplified sequence 2

120

4e-06

32% (25/76)

ACL00002312

unclassified

ACL00002313

Unknown EST

82

1e-08

60% (14/23)

ACL00002314

P4Hc domain containing protein

157

8e-13

23% (30/130)

ACL00002315

Luminal binding protein 3 precursor related cluster

281

7e-25

77% (54/70)

GO:0005524|ATP binding|IEA; GO:0005783|endoplasmic reticulum|IEA

ACL00002316

unclassified

ACL00002317

Cyclic GMP-binding protein C related cluster

235

2e-19

50% (50/99)

GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0004713|protein-tyrosine kinase activity|IEA; GO:0005085|guanyl-nucleotide exchange factor activity|IEA; GO:0005524|ATP binding|IEA; GO:0005525|GTP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0007242|intracellular signaling cascade|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00002320

zgc:56139

zgc:56139; similar to DEAD (Asp-Glu-Ala-Asp) box polypeptide 48

376

5e-36

89% (69/77)

ACL00002324

Ras-related protein Rab7 related cluster

234

2e-19

66% (46/69)

GO:0000160|two-component signal transduction system (phosphorelay)|IEA; GO:0003677|DNA binding|IEA; GO:0005525|GTP binding|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0007264|small GTPase mediated signal transduction|IEA; GO:0015031|protein transport|IEA

ACL00002325

Rps15a

40S ribosomal protein S15a related cluster

419

7e-41

78% (75/96)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003723|RNA binding|TAS; GO:0003735|structural constituent of ribosome|TAS; GO:0005843|cytosolic small ribosomal subunit (sensu Eukaryota)|TAS; GO:0006412|protein biosynthesis|TAS

ACL00002327

Psmd11

26S proteasome non-ATPase regulatory subunit 11 related cluster

137

2e-75

61% (26/42)

Posttranslational modification, protein turnover, chaperones

Proteasome

GO:0005488|binding|IEA; GO:0005829|cytosol|IEA

ACL00002329

Putative nucleosome assembly protein 1 related cluster

126

2e-06

28% (34/120)

GO:0005634|nucleus|IEA; GO:0006334|nucleosome assembly|IEA

ACL00002330

3-methylcrotonyl-CoA carboxylase, beta subunit, putative related cluster

373

3e-35

77% (69/89)

Lipid transport and metabolism

GO:0004075|biotin carboxylase activity|IEA; GO:0009343|biotin carboxylase complex|IEA

ACL00002331

RPL11B

60S ribosomal protein L11 related cluster

614

6e-63

67% (114/169)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003723|RNA binding|TAS; GO:0003735|structural constituent of ribosome|TAS; GO:0005842|cytosolic large ribosomal subunit (sensu Eukaryota)|TAS; GO:0006412|protein biosynthesis|TAS

ACL00002336

unclassified

ACL00002339

Tubulin beta-1 chain related cluster

541

2e-54

68% (102/148)

Cytoskeleton

GO:0003924|GTPase activity|IEA; GO:0005198|structural molecule activity|IEA; GO:0005525|GTP binding|IEA; GO:0005634|nucleus|IEA; GO:0005874|microtubule|IEA; GO:0007018|microtubule-based movement|IEA; GO:0045298|tubulin|IEA; GO:0046785|microtubule polymerization|IEA

ACL00002340

grxC

Glutaredoxin 3 related cluster

221

1e-17

55% (44/80)

Posttranslational modification, protein turnover, chaperones

GO:0005489|electron transporter activity|IEA; GO:0006118|electron transport|IEA

ACL00002341

Similar to Kaposi's sarcoma-associated herpesvirus (KSHV) (Human herpesvirus 8). latent nuclear antigen related cluster

121

3e-06

33% (40/120)

ACL00002342

[K] COG5157 RNA polymerase II assessory factor

49

1e-21

36% (8/22)

Transcription

ACL00002343

UPF0220 domain containing protein

177

9e-14

29% (31/104)

ACL00002345

multi-domain protein

116

1e-06

32% (33/102)

ACL00002346

unclassified

ACL00002347

unclassified

ACL00002348

UCHL1

Ubiquitin carboxyl-terminal hydrolase isozyme L1 related cluster

74

6e-20

43% (16/37)

3.4.19.12

GO:0004197|cysteine-type endopeptidase activity|IDA; GO:0004221|ubiquitin thiolesterase activity|IEA; GO:0004221|ubiquitin thiolesterase activity|TAS; GO:0005622|intracellular|IEA; GO:0005737|cytoplasm|ISS; GO:0006511|ubiquitin-dependent protein catabolism|IEA; GO:0006511|ubiquitin-dependent protein catabolism|NR; GO:0006512|ubiquitin cycle|IEA; GO:0008234|cysteine-type peptidase activity|IEA; GO:0008242|omega peptidase activity|IDA; GO:0016579|protein deubiquitination|IDA; GO:0016787|hydrolase activity|IEA; GO:0043130|ubiquitin binding|IDA

ACL00002350

CCAAT-binding transcription factor subunit A related cluster

318

7e-29

74% (65/87)

GO:0003677|DNA binding|IEA; GO:0005634|nucleus|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA

ACL00002351

Similar to Mus musculus (Mouse). similar to S-adenosylmethionine decarboxylase 1 related cluster

703

6e-73

43% (141/325)

GO:0004014|adenosylmethionine decarboxylase activity|IEA; GO:0006597|spermine biosynthesis|IEA; GO:0008295|spermidine biosynthesis|IEA

ACL00002352

reduced viability upon starvation protein homolog

244

1e-19

24% (62/250)

ACL00002353

NUP62

Nuclear pore glycoprotein p62 related cluster

319

2e-28

34% (79/228)

GO:0005634|nucleus|IEA; GO:0005643|nuclear pore|IEA; GO:0005643|nuclear pore|TAS; GO:0006810|transport|IEA; GO:0017056|structural constituent of nuclear pore|IEA

ACL00002354

zgc:56616

Similar to peptidylprolyl isomerase (Cyclophilin)-like 2 related cluster

237

2e-19

42% (54/127)

Posttranslational modification, protein turnover, chaperones

GO:0000151|ubiquitin ligase complex|IEA; GO:0003755|peptidyl-prolyl cis-trans isomerase activity|IEA; GO:0004842|ubiquitin-protein ligase activity|IEA; GO:0006457|protein folding|IEA; GO:0016567|protein ubiquitination|IEA; GO:0016853|isomerase activity|IEA

ACL00002355

Iojap-related protein related cluster

187

9e-14

36% (39/108)

Function unknown

GO:0005554|molecular_function unknown|IEA

ACL00002356

multi-domain protein

124

1e-07

28% (30/107)

ACL00002357

CG2849

Ras-like protein 1 related cluster

456

1e-44

56% (89/157)

GO:0005525|GTP binding|IEA; GO:0007264|small GTPase mediated signal transduction|IEA

ACL00002358

Eukaryotic translation initiation factor 4E-1 related cluster

230

3e-18

37% (44/117)

Translation, ribosomal structure and biogenesis

GO:0003723|RNA binding|IEA; GO:0003743|translation initiation factor activity|IEA; GO:0005737|cytoplasm|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006413|translational initiation|IEA; GO:0006417|regulation of protein biosynthesis|IEA; GO:0006445|regulation of translation|IEA

ACL00002359