Automatic annotation results for R_prowazekii.fasta

Ssequence id

Locus

Description

Alignment Score

E-value

% Sequence Identity

EC number

COG Function

KEGG Pathways

GeneOntology

RP002

trxA

Thioredoxin related cluster

516

5e-52

93% (98/105)

GO:0005489|electron transporter activity|IEA; GO:0006118|electron transport|IEA

RP003

wzt

O-antigen export system ATP-binding protein related cluster

1174

1e-128

91% (230/252)

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0016887|ATPase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

RP004

wzm

O-ANTIGEN EXPORT SYSTEM PERMEASE PROTEIN RFBA related cluster

1235

1e-136

95% (246/258)

GO:0005524|ATP binding|IEA; GO:0006810|transport|IEA; GO:0016020|membrane|IEA; GO:0042626|ATPase activity, coupled to transmembrane movement of substances|IEA

RP007

LPXA

Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase related cluster

1244

1e-137

90% (239/264)

2.3.1.129

Cell wall/membrane/envelope biogenesis

Lipopolysaccharide biosynthesis

GO:0008415|acyltransferase activity|IEA; GO:0008610|lipid biosynthesis|IEA; GO:0008780|acyl-[acyl-carrier protein]-UDP-N-acetylglucosamine O-acyltransferase activity|IEA; GO:0009245|lipid A biosynthesis|IEA; GO:0016740|transferase activity|IEA

RP008

fabZ

(3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase (EC 4.2.1.-) ((3R)-hydroxymyristoyl ACP dehydrase) related cluster

660

8e-69

91% (132/144)

4.2.1.-

Lipid transport and metabolism

GO:0003824|catalytic activity|IEA; GO:0005737|cytoplasm|IEA; GO:0006633|fatty acid biosynthesis|IEA; GO:0008610|lipid biosynthesis|IEA; GO:0009245|lipid A biosynthesis|IEA; GO:0016829|lyase activity|IEA; GO:0016836|hydro-lyase activity|IEA

RP009

lpxD

UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase related cluster

1494

1e-166

84% (292/346)

2.3.1.-

Cell wall/membrane/envelope biogenesis

Lipopolysaccharide biosynthesis

GO:0008415|acyltransferase activity|IEA; GO:0008610|lipid biosynthesis|IEA; GO:0009245|lipid A biosynthesis|IEA; GO:0016740|transferase activity|IEA; GO:0016747|transferase activity, transferring groups other than amino-acyl groups|IEA

RP011

nifR3

NifR3 family protein related cluster

1022

1e-111

63% (201/318)

GO:0008033|tRNA processing|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0050660|FAD binding|IEA

RP015

Polynucleotide adenylyltransferase related cluster

1803

0.0

91% (355/387)

GO:0003723|RNA binding|IEA; GO:0004652|polynucleotide adenylyltransferase activity|IEA; GO:0006396|RNA processing|IEA; GO:0016779|nucleotidyltransferase activity|IEA

RP018

sca1

190 kDa antigen related cluster

1578

1e-176

87% (305/347)

RP020

ATPF

ATP synthase B chain related cluster

723

4e-76

89% (150/167)

3.6.3.14

Energy production and conversion

ATP synthesis Oxidative phosphorylation

GO:0015078|hydrogen ion transporter activity|IEA; GO:0015986|ATP synthesis coupled proton transport|IEA; GO:0015992|proton transport|IEA; GO:0016021|integral to membrane|IEA; GO:0016469|proton-transporting two-sector ATPase complex|IEA; GO:0016820|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|IEA

RP021

atpX

ATP SYNTHASE B CHAIN related cluster

689

4e-72

89% (141/158)

3.6.3.14

Energy production and conversion

ATP synthesis Oxidative phosphorylation

GO:0006810|transport|IEA; GO:0006811|ion transport|IEA; GO:0015078|hydrogen ion transporter activity|IEA; GO:0015986|ATP synthesis coupled proton transport|IEA; GO:0015992|proton transport|IEA; GO:0016021|integral to membrane|IEA; GO:0016469|proton-transporting two-sector ATPase complex|IEA; GO:0016820|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|IEA

RP022

ATPL

ATP synthase C chain related cluster

329

1e-30

93% (69/74)

3.6.3.14

Energy production and conversion

ATP synthesis Oxidative phosphorylation

GO:0008289|lipid binding|IEA; GO:0015078|hydrogen ion transporter activity|IEA; GO:0015986|ATP synthesis coupled proton transport|IEA; GO:0015992|proton transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016469|proton-transporting two-sector ATPase complex|IEA; GO:0046933|hydrogen-transporting ATP synthase activity, rotational mechanism|IEA; GO:0046961|hydrogen-transporting ATPase activity, rotational mechanism|IEA

RP023

ATP6

ATP synthase a chain related cluster

1090

1e-119

88% (214/242)

3.6.3.14

Energy production and conversion

ATP synthesis Oxidative phosphorylation

GO:0015078|hydrogen ion transporter activity|IEA; GO:0015992|proton transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016469|proton-transporting two-sector ATPase complex|IEA; GO:0016820|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|IEA

RP029

recF

DNA replication and repair protein recF related cluster

1705

0.0

93% (338/360)

Replication, recombination and repair

GO:0003677|DNA binding|IEA; GO:0003697|single-stranded DNA binding|IEA; GO:0005524|ATP binding|IEA; GO:0005634|nucleus|IEA; GO:0006260|DNA replication|IEA; GO:0006281|DNA repair|IEA; GO:0006974|response to DNA damage stimulus|IEA; GO:0007001|chromosome organization and biogenesis (sensu Eukaryota)|IEA; GO:0009432|SOS response|IEA

RP031

sco2

SCO2-like protein RP031 related cluster

821

2e-87

85% (164/191)

GO:0006118|electron transport|IEA

RP035

phbB

Acetoacetyl-CoA reductase related cluster

1174

1e-129

95% (230/241)

1.1.1.36

Butanoate metabolism

GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0018454|acetoacetyl-CoA reductase activity|IEA

RP036

clpB

Chaperone clpB related cluster

3923

0.0

93% (798/858)

Posttranslational modification, protein turnover, chaperones

GO:0000166|nucleotide binding|IEA; GO:0005515|protein binding|IEA; GO:0005524|ATP binding|IEA; GO:0006457|protein folding|IEA; GO:0006986|response to unfolded protein|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA; GO:0019538|protein metabolism|IEA; GO:0051082|unfolded protein binding|IEA

RP037

O-sialoglycoprotein endopeptidase related cluster

1800

0.0

91% (353/387)

GO:0006508|proteolysis and peptidolysis|IEA; GO:0008450|O-sialoglycoprotein endopeptidase activity|IEA

RP038

aco1

Acyl-CoA desaturase 1 related cluster

1951

0.0

92% (364/395)

1.14.19.1

Lipid transport and metabolism

GO:0004768|stearoyl-CoA 9-desaturase activity|IEA; GO:0005506|iron ion binding|IEA; GO:0005783|endoplasmic reticulum|IEA; GO:0006633|fatty acid biosynthesis|IEA; GO:0016020|membrane|IEA; GO:0016491|oxidoreductase activity|IEA

RP039

rpsF

30S ribosomal protein S6 related cluster

603

3e-62

96% (117/121)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0019843|rRNA binding|IEA

RP040

rpsR

30S ribosomal protein S18 related cluster

382

2e-36

83% (79/95)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003723|RNA binding|IEA; GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0019843|rRNA binding|IEA

RP041

rplI

50S ribosomal protein L9 related cluster

760

2e-80

91% (157/171)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0019843|rRNA binding|IEA

RP042

mesJ

Cell cycle protein MesJ related cluster

1858

0.0

84% (365/430)

Cell cycle control, cell division, chromosome partitioning

RP043

ftsH

Cell division protein ftsH homolog related cluster

2892

0.0

90% (575/637)

3.4.24.-

GO:0000166|nucleotide binding|IEA; GO:0000910|cytokinesis|IEA; GO:0004222|metalloendopeptidase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008237|metallopeptidase activity|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016787|hydrolase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA; GO:0030163|protein catabolism|IEA

RP044

DHSB

Succinate dehydrogenase iron-sulfur protein related cluster

1352

1e-149

93% (245/261)

1.3.99.1

Energy production and conversion

Benzoate degradation via CoA ligation Butanoate metabolism Citrate cycle (TCA cycle) Oxidative phosphorylation Reductive carboxylate cycle (CO2 fixation)

GO:0000104|succinate dehydrogenase activity|IEA; GO:0005489|electron transporter activity|IEA; GO:0005506|iron ion binding|IEA; GO:0006099|tricarboxylic acid cycle|IEA; GO:0006118|electron transport|IEA; GO:0016491|oxidoreductase activity|IEA

RP046

lgt

Prolipoprotein diacylglyceryl transferase related cluster

1292

1e-142

94% (253/268)

2.4.99.-

Cell wall/membrane/envelope biogenesis

Blood group glycolipid biosynthesis-neolactoseries Ganglioside biosynthesis Globoside metabolism

GO:0008961|phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity|IEA; GO:0009249|protein-lipoylation|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016740|transferase activity|IEA; GO:0019866|inner membrane|IEA; GO:0042158|lipoprotein biosynthesis|IEA

RP048

yidC

Inner membrane protein oxaA related cluster

2639

0.0

91% (501/546)

Protein export

GO:0016021|integral to membrane|IEA; GO:0019866|inner membrane|IEA; GO:0051205|protein insertion into membrane|IEA

RP049

PGSA

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase related cluster

799

6e-85

89% (162/181)

2.7.8.5

Lipid transport and metabolism

Glycerolipid metabolism

GO:0008444|CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity|IEA; GO:0008654|phospholipid biosynthesis|IEA; GO:0016021|integral to membrane|IEA; GO:0016740|transferase activity|IEA

RP053

tlcA

ADP,ATP carrier protein 1 related cluster

2536

0.0

100% (498/498)

Energy production and conversion

GO:0005471|ATP:ADP antiporter activity|IEA; GO:0005524|ATP binding|IEA; GO:0006810|transport|IEA; GO:0016021|integral to membrane|IEA

RP054

glpT

Glycerol-3-phosphate transporter related cluster

1912

0.0

84% (362/429)

Carbohydrate transport and metabolism

GO:0005215|transporter activity|IEA; GO:0006810|transport|IEA; GO:0016021|integral to membrane|IEA

RP055

NDK

Nucleoside diphosphate kinase related cluster

669

7e-70

94% (132/140)

2.7.4.6

Nucleotide transport and metabolism

GO:0000166|nucleotide binding|IEA; GO:0000287|magnesium ion binding|IEA; GO:0004550|nucleoside-diphosphate kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006183|GTP biosynthesis|IEA; GO:0006228|UTP biosynthesis|IEA; GO:0006241|CTP biosynthesis|IEA; GO:0009117|nucleotide metabolism|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

RP056

gidA

Glucose inhibited division protein A related cluster

2689

0.0

86% (539/621)

Cell cycle control, cell division, chromosome partitioning

GO:0005554|molecular_function unknown|IEA; GO:0006118|electron transport|IEA; GO:0015036|disulfide oxidoreductase activity|IEA; GO:0016491|oxidoreductase activity|IEA

RP057

gidB

Methyltransferase gidB related cluster

902

5e-97

94% (180/191)

2.1.-.-

Cell wall/membrane/envelope biogenesis

GO:0007049|cell cycle|IEA; GO:0008168|methyltransferase activity|IEA; GO:0016740|transferase activity|IEA

RP058

soj

SOJ PROTEIN related cluster

1270

1e-140

100% (255/255)

GO:0009236|cobalamin biosynthesis|IEA; GO:0042242|cobyrinic acid a,c-diamide synthase activity|IEA

RP059

spo0J

Stage 0 sporulation protein J related cluster

1132

1e-124

79% (226/286)

GO:0003677|DNA binding|IEA; GO:0030542|plasmid partitioning (sensu Bacteria)|IEA

RP060

ABC TRANSPORTER ATP-BINDING PROTEIN related cluster

2786

0.0

96% (538/555)

General function prediction only

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0016887|ATPase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

RP062

KDSA

2-dehydro-3-deoxyphosphooctonate aldolase related cluster

1341

1e-148

96% (266/275)

2.5.1.55

GO:0005737|cytoplasm|IEA; GO:0008152|metabolism|IEA; GO:0008676|3-deoxy-8-phosphooctulonate synthase activity|IEA; GO:0009058|biosynthesis|IEA; GO:0009103|lipopolysaccharide biosynthesis|IEA; GO:0016740|transferase activity|IEA

RP063

iscA1, iscA, hesB

HesB protein related cluster

525

4e-53

90% (99/110)

GO:0005554|molecular_function unknown|IEA

RP064

Deoxyguanosinetriphosphate triphosphohydrolase-like protein related cluster

1985

0.0

100% (383/383)

Nucleotide transport and metabolism

GO:0000287|magnesium ion binding|IEA; GO:0003824|catalytic activity|IEA; GO:0008832|dGTPase activity|IEA; GO:0016787|hydrolase activity|IEA; GO:0046039|GTP metabolism|IEA

RP065

SYR

Arginyl-tRNA synthetase related cluster

2664

0.0

89% (517/576)

6.1.1.19

Translation, ribosomal structure and biogenesis

GO:0004812|tRNA ligase activity|IEA; GO:0004814|arginine-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006418|tRNA aminoacylation for protein translation|IEA; GO:0006420|arginyl-tRNA aminoacylation|IEA; GO:0016874|ligase activity|IEA

RP067

parC

Topoisomerase IV subunit A related cluster

3594

0.0

96% (714/738)

5.99.1.-

Replication, recombination and repair

GO:0003677|DNA binding|IEA; GO:0003916|DNA topoisomerase activity|IEA; GO:0003918|DNA topoisomerase (ATP-hydrolyzing) activity|IEA; GO:0005524|ATP binding|IEA; GO:0005694|chromosome|IEA; GO:0006259|DNA metabolism|IEA; GO:0006265|DNA topological change|IEA; GO:0006268|DNA unwinding|IEA; GO:0016853|isomerase activity|IEA

RP069

DCD

Deoxycytidine triphosphate deaminase related cluster

959

1e-103

96% (181/188)

3.5.4.13

Nucleotide transport and metabolism

Pyrimidine metabolism

GO:0008829|dCTP deaminase activity|IEA; GO:0009117|nucleotide metabolism|IEA; GO:0009220|pyrimidine ribonucleotide biosynthesis|IEA; GO:0016787|hydrolase activity|IEA

RP070

secB

Protein-export protein secB related cluster

779

1e-82

100% (152/152)

Intracellular trafficking, secretion, and vesicular transport

Protein export

GO:0006605|protein targeting|IEA; GO:0015031|protein transport|IEA; GO:0051082|unfolded protein binding|IEA; GO:0051262|protein tetramerization|IEA

RP071

czcR

TRANSCRIPTIONAL ACTIVATOR PROTEIN CZCR related cluster

1174

1e-129

100% (237/237)

GO:0000156|two-component response regulator activity|IEA; GO:0000160|two-component signal transduction system (phosphorelay)|IEA; GO:0003677|DNA binding|IEA; GO:0006350|transcription|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0007600|sensory perception|IEA

RP074

pntB

NAD(P)(+) transhydrogenase (B-specific) beta subunit related cluster

1736

0.0

79% (359/451)

1.6.1.1

Energy production and conversion

Nicotinate and nicotinamide metabolism

GO:0006118|electron transport|IEA; GO:0008746|NAD(P) transhydrogenase activity|IEA

RP077

proP1

Proline/betaine transporter ProP1 related cluster

1964

0.0

91% (381/418)

GO:0005215|transporter activity|IEA; GO:0006810|transport|IEA; GO:0016021|integral to membrane|IEA

RP079

secG

Protein-export membrane protein secG related cluster

354

3e-33

77% (77/100)

Intracellular trafficking, secretion, and vesicular transport

Protein export

GO:0006605|protein targeting|IEA; GO:0009306|protein secretion|IEA; GO:0015031|protein transport|IEA; GO:0015450|protein translocase activity|IEA; GO:0016021|integral to membrane|IEA

RP081

sca2

190 kDa antigen related cluster

1473

1e-163

84% (288/341)

RP085

SYC

Cysteinyl-tRNA synthetase related cluster

2426

0.0

100% (457/457)

6.1.1.16

Translation, ribosomal structure and biogenesis

Aminoacyl-tRNA biosynthesis Cysteine metabolism

GO:0004812|tRNA ligase activity|IEA; GO:0004817|cysteine-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006423|cysteinyl-tRNA aminoacylation|IEA; GO:0008270|zinc ion binding|IEA; GO:0016874|ligase activity|IEA

RP086

rpsB

30S ribosomal protein S2 related cluster

1325

1e-146

88% (261/296)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0015935|small ribosomal subunit|IEA

RP087

tsf

Elongation factor Ts related cluster

1413

1e-156

94% (293/309)

Translation, ribosomal structure and biogenesis

GO:0003746|translation elongation factor activity|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006414|translational elongation|IEA

RP089

waaA

3-deoxy-D-manno-octulosonic-acid transferase related cluster

2252

0.0

96% (443/461)

2.-.-.-

Cell wall/membrane/envelope biogenesis

Lipopolysaccharide biosynthesis

GO:0005529|sugar binding|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0009103|lipopolysaccharide biosynthesis|IEA; GO:0016021|integral to membrane|IEA; GO:0016740|transferase activity|IEA; GO:0019866|inner membrane|IEA

RP091

AAT

Aspartate aminotransferase related cluster

2053

0.0

100% (399/399)

2.6.1.1

Amino acid transport and metabolism

Alanine and aspartate metabolism Arginine and proline metabolism Carbon fixation Cysteine metabolism Glutamate metabolism Phenylalanine, tyrosine and tryptophan biosynthesis Tyrosine metabolism

GO:0003824|catalytic activity|IEA; GO:0004069|aspartate transaminase activity|IEA; GO:0008483|transaminase activity|IEA; GO:0009058|biosynthesis|IEA; GO:0016740|transferase activity|IEA; GO:0016847|1-aminocyclopropane-1-carboxylate synthase activity|IEA

RP093

vacJ

VacJ lipoprotein related cluster

1164

1e-127

91% (216/235)

Cell wall/membrane/envelope biogenesis

GO:0016020|membrane|IEA

RP095

ALR

Alanine racemase related cluster

2071

0.0

100% (404/404)

5.1.1.1

Cell wall/membrane/envelope biogenesis

Alanine and aspartate metabolism D-Alanine metabolism

GO:0005618|cell wall|IEA; GO:0006522|alanine metabolism|IEA; GO:0008784|alanine racemase activity|IEA; GO:0009252|peptidoglycan biosynthesis|IEA; GO:0016853|isomerase activity|IEA; GO:0030170|pyridoxal phosphate binding|IEA

RP097

mkl

Ribonucleotide ABC transporter ATP-binding protein related cluster

1105

1e-120

87% (221/252)

Secondary metabolites biosynthesis, transport and catabolism

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0016887|ATPase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

RP099

rpmB

50S ribosomal protein L28 related cluster

402

7e-39

100% (79/79)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

RP100

rpmE

50S ribosomal protein L31 related cluster

409

7e-40

100% (78/78)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

RP103

virB4a

VIRB4 PROTEIN related cluster

4159

0.0

100% (805/805)

Intracellular trafficking, secretion, and vesicular transport

Type IV secretion system

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

RP109

PTA

Phosphate acetyltransferase related cluster

1641

0.0

95% (334/351)

2.3.1.8

GO:0008152|metabolism|IEA; GO:0008415|acyltransferase activity|IEA; GO:0008959|phosphate acetyltransferase activity|IEA; GO:0016740|transferase activity|IEA

RP110

ACKA

Acetate kinase related cluster

1888

0.0

96% (372/385)

2.7.2.1

Energy production and conversion

Propanoate metabolism Pyruvate metabolism Taurine and hypotaurine metabolism

GO:0005622|intracellular|IEA; GO:0006082|organic acid metabolism|IEA; GO:0008152|metabolism|IEA; GO:0008776|acetate kinase activity|IEA; GO:0016301|kinase activity|IEA; GO:0016310|phosphorylation|IEA; GO:0016740|transferase activity|IEA; GO:0016774|phosphotransferase activity, carboxyl group as acceptor|IEA

RP111

TRMD

tRNA (Guanine-N(1)-)-methyltransferase related cluster

1232

1e-135

100% (234/234)

2.1.1.31

Translation, ribosomal structure and biogenesis

GO:0003723|RNA binding|IEA; GO:0006400|tRNA modification|IEA; GO:0008033|tRNA processing|IEA; GO:0008168|methyltransferase activity|IEA; GO:0008175|tRNA methyltransferase activity|IEA; GO:0009019|tRNA (guanine-N1-)-methyltransferase activity|IEA; GO:0016740|transferase activity|IEA

RP112

rplS

50S ribosomal protein L19 related cluster

689

3e-72

100% (138/138)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

RP114

secF

Protein-export membrane protein secF related cluster

1348

1e-149

87% (272/311)

Intracellular trafficking, secretion, and vesicular transport

Protein export

GO:0006605|protein targeting|IEA; GO:0006886|intracellular protein transport|IEA; GO:0008565|protein transporter activity|IEA; GO:0015031|protein transport|IEA; GO:0015450|protein translocase activity|IEA; GO:0015627|type II protein secretion system complex|IEA; GO:0015628|type II protein secretion system|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0019866|inner membrane|IEA

RP115

NUOF

NADH-quinone oxidoreductase chain F related cluster

2107

0.0

92% (387/417)

1.6.99.5

Energy production and conversion

Oxidative phosphorylation Ubiquinone biosynthesis

GO:0006120|mitochondrial electron transport, NADH to ubiquinone|IEA; GO:0008137|NADH dehydrogenase (ubiquinone) activity|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0050136|NADH dehydrogenase (quinone) activity|IEA

RP116

lepB

Signal peptidase I related cluster

1334

1e-147

95% (253/264)

3.4.21.89

Intracellular trafficking, secretion, and vesicular transport

Protein export

GO:0006508|proteolysis and peptidolysis|IEA; GO:0008236|serine-type peptidase activity|IEA; GO:0009004|signal peptidase I activity|IEA; GO:0016020|membrane|IEA; GO:0016787|hydrolase activity|IEA

RP117

RNC

Ribonuclease III related cluster

1161

1e-127

100% (225/225)

3.1.26.3

Transcription

GO:0003723|RNA binding|IEA; GO:0003725|double-stranded RNA binding|IEA; GO:0004518|nuclease activity|IEA; GO:0004519|endonuclease activity|IEA; GO:0004525|ribonuclease III activity|IEA; GO:0005622|intracellular|IEA; GO:0006364|rRNA processing|IEA; GO:0006396|RNA processing|IEA; GO:0006397|mRNA processing|IEA; GO:0016787|hydrolase activity|IEA

RP118

GTP-binding protein era homolog related cluster

1494

1e-166

100% (295/295)

General function prediction only

GO:0003676|nucleic acid binding|IEA; GO:0003723|RNA binding|IEA; GO:0005525|GTP binding|IEA; GO:0008151||IEA

RP119

RUVC

Crossover junction endodeoxyribonuclease ruvC related cluster

796

1e-84

100% (157/157)

3.1.22.4

Replication, recombination and repair

GO:0000287|magnesium ion binding|IEA; GO:0004518|nuclease activity|IEA; GO:0004520|endodeoxyribonuclease activity|IEA; GO:0006281|DNA repair|IEA; GO:0006310|DNA recombination|IEA; GO:0008821|crossover junction endodeoxyribonuclease activity|IEA; GO:0016787|hydrolase activity|IEA; GO:0016978|lipoate-protein ligase B activity|IEA

RP122

hflK

HFLK PROTEIN related cluster

1691

0.0

100% (331/331)

GO:0005515|protein binding|IEA; GO:0016021|integral to membrane|IEA

RP123

hflC

HFLC PROTEIN related cluster

1410

1e-156

100% (286/286)

3.4.-.-

GO:0005515|protein binding|IEA; GO:0008233|peptidase activity|IEA; GO:0016021|integral to membrane|IEA

RP124

Serine protease, HtrA/DegQ/DegS family related cluster

2257

0.0

89% (457/513)

3.4.21.-

Posttranslational modification, protein turnover, chaperones

GO:0004252|serine-type endopeptidase activity|IEA; GO:0004295|trypsin activity|IEA; GO:0005515|protein binding|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

RP126

sdhC

Succinate dehydrogenase cytochrome b-556 subunit related cluster

615

1e-63

91% (113/124)

1.3.99.1

Energy production and conversion

Benzoate degradation via CoA ligation Butanoate metabolism Citrate cycle (TCA cycle) Oxidative phosphorylation Reductive carboxylate cycle (CO2 fixation)

GO:0000104|succinate dehydrogenase activity|IEA; GO:0006099|tricarboxylic acid cycle|IEA; GO:0006118|electron transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0019866|inner membrane|IEA

RP127

sdhD

Succinate dehydrogenase hydrophobic membrane anchor protein related cluster

596

2e-61

92% (115/125)

1.3.99.1

Energy production and conversion

Benzoate degradation via CoA ligation Butanoate metabolism Citrate cycle (TCA cycle) Oxidative phosphorylation Reductive carboxylate cycle (CO2 fixation)

GO:0000104|succinate dehydrogenase activity|IEA; GO:0006099|tricarboxylic acid cycle|IEA; GO:0006118|electron transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0019866|inner membrane|IEA

RP128

DHSA

Succinate dehydrogenase flavoprotein subunit related cluster

2928

0.0

92% (552/596)

1.3.99.1

Energy production and conversion

Benzoate degradation via CoA ligation Butanoate metabolism Citrate cycle (TCA cycle) Oxidative phosphorylation Reductive carboxylate cycle (CO2 fixation)

GO:0000104|succinate dehydrogenase activity|IEA; GO:0006099|tricarboxylic acid cycle|IEA; GO:0006118|electron transport|IEA; GO:0015036|disulfide oxidoreductase activity|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016627|oxidoreductase activity, acting on the CH-CH group of donors|IEA

RP129

glnP

Glutamine transport system permease protein GlnP related cluster

1034

1e-112

95% (208/218)

Amino acid transport and metabolism

GO:0005215|transporter activity|IEA; GO:0006810|transport|IEA; GO:0016020|membrane|IEA

RP130

rpsL

30S ribosomal protein S12 related cluster

650

1e-67

98% (127/129)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0000049|tRNA binding|IEA; GO:0003723|RNA binding|IEA; GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0015935|small ribosomal subunit|IEA; GO:0019843|rRNA binding|IEA

RP131

rpsG

30S ribosomal protein S7 related cluster

793

2e-84

96% (154/160)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0000049|tRNA binding|IEA; GO:0003723|RNA binding|IEA; GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0015935|small ribosomal subunit|IEA; GO:0019843|rRNA binding|IEA

RP132

fusA

Elongation factor G related cluster

3297

0.0

90% (636/699)

3.6.5.3

Translation, ribosomal structure and biogenesis

GO:0003746|translation elongation factor activity|IEA; GO:0005525|GTP binding|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006414|translational elongation|IEA

RP135

nusG

Transcription antitermination protein nusG related cluster

872

2e-93

89% (172/192)

Transcription

GO:0003711|transcriptional elongation regulator activity|IEA; GO:0006353|transcription termination|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA

RP136

rplK

50S ribosomal protein L11 related cluster

618

7e-64

86% (126/145)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0019843|rRNA binding|IEA

RP137

rplA

50S ribosomal protein L1 related cluster

1085

1e-118

92% (220/238)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003723|RNA binding|IEA; GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA; GO:0015934|large ribosomal subunit|IEA; GO:0019843|rRNA binding|IEA

RP138

rplJ

50S ribosomal protein L10 related cluster

824

6e-88

99% (168/169)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

RP139

rplL

50S ribosomal protein L7/L12 related cluster

515

5e-52

89% (112/125)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

RP140

RPOB

DNA-directed RNA polymerase beta chain related cluster

6953

0.0

99% (1363/1374)

2.7.7.6

Transcription

Purine metabolism Pyrimidine metabolism RNA polymerase

GO:0003677|DNA binding|IEA; GO:0003899|DNA-directed RNA polymerase activity|IEA; GO:0006350|transcription|IEA; GO:0006351|transcription, DNA-dependent|IEA; GO:0016740|transferase activity|IEA; GO:0046677|response to antibiotic|IEA

RP141

RPOC

DNA-directed RNA polymerase beta' chain related cluster

6643

0.0

95% (1311/1372)

2.7.7.6

Transcription

Purine metabolism Pyrimidine metabolism RNA polymerase

GO:0003677|DNA binding|IEA; GO:0003899|DNA-directed RNA polymerase activity|IEA; GO:0005634|nucleus|IEA; GO:0006350|transcription|IEA; GO:0006351|transcription, DNA-dependent|IEA; GO:0016740|transferase activity|IEA

RP142

AMPA

Cytosol aminopeptidase related cluster

2454

0.0

97% (488/500)

3.4.11.1

Amino acid transport and metabolism

GO:0004177|aminopeptidase activity|IEA; GO:0004178|leucyl aminopeptidase activity|IEA; GO:0005622|intracellular|IEA; GO:0005737|cytoplasm|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0016787|hydrolase activity|IEA; GO:0019538|protein metabolism|IEA; GO:0030145|manganese ion binding|IEA

RP145

SYD

Aspartyl-tRNA synthetase related cluster

3043

0.0

98% (593/605)

6.1.1.12

Translation, ribosomal structure and biogenesis

GO:0000287|magnesium ion binding|IEA; GO:0003676|nucleic acid binding|IEA; GO:0004812|tRNA ligase activity|IEA; GO:0004815|aspartate-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0005737|cytoplasm|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006418|tRNA aminoacylation for protein translation|IEA; GO:0006422|aspartyl-tRNA aminoacylation|IEA; GO:0016874|ligase activity|IEA

RP148

DAPB

Dihydrodipicolinate reductase related cluster

1156

1e-126

96% (231/239)

1.3.1.26

Amino acid transport and metabolism

Lysine biosynthesis

GO:0008839|dihydrodipicolinate reductase activity|IEA; GO:0009085|lysine biosynthesis|IEA; GO:0009089|lysine biosynthesis via diaminopimelate|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0019877|diaminopimelate biosynthesis|IEA

RP150

glnH

AMINO-ACID ABC TRANSPORTER BINDING PROTEIN related cluster

1040

1e-113

92% (212/228)

GO:0005215|transporter activity|IEA; GO:0006810|transport|IEA; GO:0030288|periplasmic space (sensu Gram-negative Bacteria)|IEA

RP151

gatB

Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B related cluster

2004

0.0

82% (398/483)

6.3.5.7

Translation, ribosomal structure and biogenesis

GO:0006412|protein biosynthesis|IEA; GO:0016874|ligase activity|IEA; GO:0016884|carbon-nitrogen ligase activity, with glutamine as amido-N-donor|IEA; GO:0017068|glutamyl-tRNA(Gln) amidotransferase activity|IEA

RP152

gatA

Glutamyl-tRNA(Gln) amidotransferase subunit A related cluster

2231

0.0

88% (437/493)

6.3.5.7

Translation, ribosomal structure and biogenesis

GO:0004040|amidase activity|IEA; GO:0006412|protein biosynthesis|IEA; GO:0016874|ligase activity|IEA; GO:0017068|glutamyl-tRNA(Gln) amidotransferase activity|IEA

RP153

gatC

Glutamyl-tRNA(Gln) amidotransferase subunit C related cluster

490

4e-49

100% (100/100)

6.3.5.7

Translation, ribosomal structure and biogenesis

GO:0006412|protein biosynthesis|IEA; GO:0006450|regulation of translational fidelity|IEA; GO:0016874|ligase activity|IEA; GO:0017068|glutamyl-tRNA(Gln) amidotransferase activity|IEA

RP154

frr

Ribosome recycling factor related cluster

916

1e-98

100% (186/186)

Translation, ribosomal structure and biogenesis

GO:0006412|protein biosynthesis|IEA; GO:0006415|translational termination|IEA

RP155

pyrH

Uridylate kinase related cluster

1148

1e-125

95% (228/240)

2.7.1.48

Nucleotide transport and metabolism

Pyrimidine metabolism

GO:0006221|pyrimidine nucleotide biosynthesis|IEA; GO:0008652|amino acid biosynthesis|IEA; GO:0009041|uridylate kinase activity|IEA; GO:0016301|kinase activity|IEA; GO:0016740|transferase activity|IEA

RP157

emrB

Multidrug resistance protein B related cluster

2307

0.0

88% (458/519)

GO:0015520|tetracycline:hydrogen antiporter activity|IEA; GO:0015904|tetracycline transport|IEA; GO:0016021|integral to membrane|IEA

RP162

nusB

N utilization substance protein B homolog related cluster

784

3e-83

100% (155/155)

GO:0003723|RNA binding|IEA; GO:0006353|transcription termination|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA

RP163

ftsJ

Ribosomal RNA large subunit methyltransferase J (EC 2.1.1.-) (rRNA (uridine-2'-O-)-methyltransferase) related cluster

1154

1e-126

100% (227/227)

2.1.1.-

Translation, ribosomal structure and biogenesis

GO:0006364|rRNA processing|IEA; GO:0008168|methyltransferase activity|IEA; GO:0016740|transferase activity|IEA

RP170

acrD

Acriflavin resistance protein D related cluster

4418

0.0

87% (883/1008)

RP171

hupA

DNA-binding protein HU related cluster

524

5e-53

87% (96/110)

Replication, recombination and repair

GO:0003677|DNA binding|IEA

RP172

holB

DNA POLYMERASE III, DELTA SUBUNIT related cluster

1302

1e-143

94% (253/269)

2.7.7.7

DNA polymerase Purine metabolism Pyrimidine metabolism

RP173

ffh

Signal recognition particle protein related cluster

2179

0.0

100% (449/449)

Intracellular trafficking, secretion, and vesicular transport

Protein export

GO:0000166|nucleotide binding|IEA; GO:0003723|RNA binding|IEA; GO:0005525|GTP binding|IEA; GO:0005786|signal recognition particle (sensu Eukaryota)|IEA; GO:0006605|protein targeting|IEA; GO:0006614|SRP-dependent cotranslational protein-membrane targeting|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

RP174

Prolyl oligopeptidase family protein related cluster

3558

0.0

93% (671/719)

GO:0004252|serine-type endopeptidase activity|IEA; GO:0004287|prolyl oligopeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008236|serine-type peptidase activity|IEA

RP175

hemN

Oxygen-independent coproporphyrinogen III oxidase related cluster

1907

0.0

93% (361/386)

1.3.3.3

Coenzyme transport and metabolism

Porphyrin and chlorophyll metabolism

GO:0003824|catalytic activity|IEA; GO:0004109|coproporphyrinogen oxidase activity|IEA; GO:0005506|iron ion binding|IEA

RP176

gltP

PROTON/SODIUM-GLUTAMATE SYMPORT PROTEIN related cluster

1719

0.0

88% (355/399)

Energy production and conversion

GO:0006835|dicarboxylic acid transport|IEA; GO:0016020|membrane|IEA; GO:0017153|sodium:dicarboxylate symporter activity|IEA

RP179

ODO2

Dihydrolipoyllysine-residue succinyltransferase component of 2- oxoglutarate dehydrogenase complex related cluster

1931

0.0

96% (388/401)

2.3.1.61

Energy production and conversion

Citrate cycle (TCA cycle) Lysine degradation

GO:0004149|dihydrolipoyllysine-residue succinyltransferase activity|IEA; GO:0005515|protein binding|IEA; GO:0006099|tricarboxylic acid cycle|IEA; GO:0008152|metabolism|IEA; GO:0008415|acyltransferase activity|IEA; GO:0016740|transferase activity|IEA; GO:0045252|oxoglutarate dehydrogenase complex|IEA

RP180

ODO1

2-oxoglutarate dehydrogenase E1 component related cluster

4709

0.0

98% (918/936)

1.2.4.2

Energy production and conversion

Citrate cycle (TCA cycle) Lysine degradation Tryptophan metabolism

GO:0004591|oxoglutarate dehydrogenase (succinyl-transferring) activity|IEA; GO:0006096|glycolysis|IEA; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016624|oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor|IEA

RP182

recN

DNA repair protein recN related cluster

2678

0.0

98% (543/554)

Replication, recombination and repair

GO:0005524|ATP binding|IEA; GO:0005634|nucleus|IEA; GO:0006281|DNA repair|IEA; GO:0006310|DNA recombination|IEA; GO:0007001|chromosome organization and biogenesis (sensu Eukaryota)|IEA; GO:0016887|ATPase activity|IEA

RP184

dnaJ

Chaperone protein dnaJ related cluster

1810

0.0

94% (348/370)

Posttranslational modification, protein turnover, chaperones

GO:0006260|DNA replication|IEA; GO:0006457|protein folding|IEA; GO:0006986|response to unfolded protein|IEA; GO:0051082|unfolded protein binding|IEA

RP185

dnaK

Chaperone protein dnaK related cluster

2836

0.0

89% (561/627)

Posttranslational modification, protein turnover, chaperones

GO:0005524|ATP binding|IEA; GO:0006457|protein folding|IEA; GO:0006986|response to unfolded protein|IEA; GO:0051082|unfolded protein binding|IEA

RP186

Heat shock protease [EC:3.4.21.-] related cluster

46

1e-162

90% (9/10)

3.4.21.-

Posttranslational modification, protein turnover, chaperones

GO:0004252|serine-type endopeptidase activity|IEA; GO:0004295|trypsin activity|IEA; GO:0005515|protein binding|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008233|peptidase activity|IEA; GO:0016787|hydrolase activity|IEA

RP190

coq7

UBIQUINONE BIOSYNTHESIS PROTEIN COQ7 related cluster

830

1e-88

92% (164/178)

Coenzyme transport and metabolism

GO:0006744|ubiquinone biosynthesis|IEA

RP191

COX3

Probable cytochrome c oxidase polypeptide III related cluster

1419

1e-157

95% (265/278)

1.9.3.1

Energy production and conversion

Oxidative phosphorylation

GO:0004129|cytochrome-c oxidase activity|IEA; GO:0006118|electron transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016491|oxidoreductase activity|IEA

RP194

DAPD

2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase related cluster

1311

1e-145

93% (255/274)

2.3.1.117

Amino acid transport and metabolism

Lysine biosynthesis

GO:0008415|acyltransferase activity|IEA; GO:0008666|2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity|IEA; GO:0009085|lysine biosynthesis|IEA; GO:0009089|lysine biosynthesis via diaminopimelate|IEA; GO:0016740|transferase activity|IEA; GO:0016757|transferase activity, transferring glycosyl groups|IEA; GO:0019877|diaminopimelate biosynthesis|IEA

RP199

fdxB

Ferredoxin, 2Fe-2S related cluster

567

4e-58

100% (112/112)

Energy production and conversion

GO:0005489|electron transporter activity|IEA; GO:0006118|electron transport|IEA

RP200

hscA

Chaperone protein hscA homolog related cluster

2951

0.0

100% (593/593)

Posttranslational modification, protein turnover, chaperones

GO:0005524|ATP binding|IEA; GO:0006457|protein folding|IEA; GO:0016887|ATPase activity|IEA; GO:0051082|unfolded protein binding|IEA

RP202

RNH2

Ribonuclease HII related cluster

924

1e-99

93% (181/193)

3.1.26.4

Replication, recombination and repair

GO:0003723|RNA binding|IEA; GO:0004518|nuclease activity|IEA; GO:0004519|endonuclease activity|IEA; GO:0004523|ribonuclease H activity|IEA; GO:0006401|RNA catabolism|IEA; GO:0016787|hydrolase activity|IEA; GO:0030145|manganese ion binding|IEA

RP203

uvrB

uvrB; excinuclease ABC subunit B [KO:K03702]

3159

0.0

94% (614/650)

Replication, recombination and repair

RP204

grxC1

Glutaredoxin related cluster

495

9e-50

100% (95/95)

Posttranslational modification, protein turnover, chaperones

GO:0005489|electron transporter activity|IEA; GO:0006118|electron transport|IEA

RP205

MITOCHONDRIAL TRANSPORTER ATM1 related cluster

3067

0.0

99% (608/609)

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0006810|transport|IEA; GO:0016021|integral to membrane|IEA; GO:0016887|ATPase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA; GO:0042626|ATPase activity, coupled to transmembrane movement of substances|IEA

RP206

GYRA

DNA gyrase subunit A related cluster

3954

0.0

89% (787/877)

5.99.1.3

Replication, recombination and repair

GO:0003677|DNA binding|IEA; GO:0003916|DNA topoisomerase activity|IEA; GO:0003918|DNA topoisomerase (ATP-hydrolyzing) activity|IEA; GO:0005524|ATP binding|IEA; GO:0005694|chromosome|IEA; GO:0006259|DNA metabolism|IEA; GO:0006265|DNA topological change|IEA; GO:0006268|DNA unwinding|IEA; GO:0016853|isomerase activity|IEA

RP208

DEF

Peptide deformylase related cluster

816

6e-87

92% (161/175)

3.5.1.88

Translation, ribosomal structure and biogenesis

GO:0006412|protein biosynthesis|IEA; GO:0008463|formylmethionine deformylase activity|IEA; GO:0016787|hydrolase activity|IEA; GO:0042586|peptide deformylase activity|IEA

RP209

FMT

Methionyl-tRNA formyltransferase related cluster

1497

1e-166

95% (289/303)

2.1.2.9

Translation, ribosomal structure and biogenesis

Aminoacyl-tRNA biosynthesis Methionine metabolism One carbon pool by folate

GO:0004479|methionyl-tRNA formyltransferase activity|IEA; GO:0006412|protein biosynthesis|IEA; GO:0008168|methyltransferase activity|IEA; GO:0009058|biosynthesis|IEA; GO:0016740|transferase activity|IEA; GO:0016742|hydroxymethyl-, formyl- and related transferase activity|IEA

RP212

PUTATIVE ATPASE N2B related cluster

1683

0.0

93% (334/357)

General function prediction only

RP213

queA

S-adenosylmethionine:tRNA ribosyltransferase-isomerase related cluster

1995

0.0

100% (383/383)

5.-.-.-

Translation, ribosomal structure and biogenesis

GO:0003824|catalytic activity|IEA; GO:0008616|queuosine biosynthesis|IEA; GO:0016740|transferase activity|IEA; GO:0016853|isomerase activity|IEA

RP216

cydA

Cytochrome d ubiquinol oxidase subunit I [EC:1.10.3.-] related cluster

1993

0.0

84% (383/453)

1.10.3.-

Energy production and conversion

Oxidative phosphorylation

GO:0006118|electron transport|IEA; GO:0016020|membrane|IEA; GO:0016491|oxidoreductase activity|IEA

RP217

cydB

CYTOCHROME D UBIQUINOL OXIDASE SUBUNIT II related cluster

1631

0.0

92% (314/339)

1.10.3.-

Energy production and conversion

Oxidative phosphorylation

GO:0006118|electron transport|IEA; GO:0016020|membrane|IEA

RP220

PUR7

Phosphoribosylaminoimidazole-succinocarboxamide synthase related cluster

1128

1e-123

92% (218/236)

6.3.2.6

Nucleotide transport and metabolism

Purine metabolism

GO:0004639|phosphoribosylaminoimidazolesuccinocarboxamide synthase activity|IEA; GO:0006164|purine nucleotide biosynthesis|IEA; GO:0016874|ligase activity|IEA

RP221

thrS

Threonine--tRNA ligase related cluster

3109

0.0

93% (593/635)

6.1.1.3

Translation, ribosomal structure and biogenesis

Aminoacyl-tRNA biosynthesis Glycine, serine and threonine metabolism

GO:0004812|tRNA ligase activity|IEA; GO:0004829|threonine-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006418|tRNA aminoacylation for protein translation|IEA; GO:0006435|threonyl-tRNA aminoacylation|IEA

RP224

tolC

OUTER MEMBRANE PROTEIN TOLC related cluster

2084

0.0

92% (422/456)

GO:0005215|transporter activity|IEA; GO:0006810|transport|IEA

RP227

parE

DNA topoisomerase IV subunit B related cluster

3273

0.0

96% (638/662)

5.99.1.-

Replication, recombination and repair

GO:0003677|DNA binding|IEA; GO:0003916|DNA topoisomerase activity|IEA; GO:0003918|DNA topoisomerase (ATP-hydrolyzing) activity|IEA; GO:0005524|ATP binding|IEA; GO:0006259|DNA metabolism|IEA; GO:0006265|DNA topological change|IEA; GO:0016853|isomerase activity|IEA

RP228

ctp

Tail-specific protease [EC:3.4.21.-] related cluster

1903

0.0

90% (398/441)

3.4.21.102

Cell wall/membrane/envelope biogenesis

GO:0005515|protein binding|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008236|serine-type peptidase activity|IEA

RP229

Histidine kinase sensor protein related cluster

2194

0.0

88% (440/495)

2.7.3.-

Signal transduction mechanisms

GO:0000155|two-component sensor molecule activity|IEA; GO:0005524|ATP binding|IEA; GO:0007165|signal transduction|IEA; GO:0016020|membrane|IEA; GO:0016310|phosphorylation|IEA; GO:0016772|transferase activity, transferring phosphorus-containing groups|IEA

RP233

rplM

50S ribosomal protein L13 related cluster

821

1e-87

99% (154/155)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

RP234

rpsI

30S ribosomal protein S9 related cluster

734

2e-77

91% (148/161)

Translation, ribosomal structure and biogenesis

Ribosome

GO:0003735|structural constituent of ribosome|IEA; GO:0005622|intracellular|IEA; GO:0005840|ribosome|IEA; GO:0006412|protein biosynthesis|IEA

RP236

nudH

(Di)nucleoside polyphosphate hydrolase (EC 3.6.1.-) ((Di)nucleoside pentaphosphate pyrophosphatase) related cluster

800

4e-85

93% (150/161)

3.6.1.-

Folate biosynthesis Starch and sucrose metabolism

GO:0000287|magnesium ion binding|IEA; GO:0016787|hydrolase activity|IEA; GO:0016818|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|IEA

RP238

efp

Elongation factor P related cluster

869

4e-93

90% (170/188)

Translation, ribosomal structure and biogenesis

GO:0003746|translation elongation factor activity|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006414|translational elongation|IEA

RP239

suhB

Extragenic suppressor protein related cluster

1214

1e-133

95% (233/245)

GO:0004437|inositol or phosphatidylinositol phosphatase activity|IEA

RP242

pssA

CDP-diacylglycerol--serine O-phosphatidyltransferase [EC:2.7.8.8] related cluster

829

2e-88

75% (168/224)

2.7.8.8

Lipid transport and metabolism

Glycerolipid metabolism Glycine, serine and threonine metabolism

GO:0008654|phospholipid biosynthesis|IEA; GO:0016740|transferase activity|IEA

RP243

emrA

Multidrug resistance protein A related cluster

1479

1e-164

85% (300/350)

Defense mechanisms

GO:0008565|protein transporter activity|IEA; GO:0009306|protein secretion|IEA; GO:0016020|membrane|IEA

RP245

bolA

BOLA PROTEIN HOMOLOG related cluster

409

7e-40

100% (80/80)

GO:0030528|transcription regulator activity|IEA

RP247

MURC

UDP-N-acetylmuramate--L-alanine ligase related cluster

2450

0.0

97% (483/495)

6.3.2.8

Cell wall/membrane/envelope biogenesis

D-Glutamine and D-glutamate metabolism Peptidoglycan biosynthesis

GO:0000910|cytokinesis|IEA; GO:0005524|ATP binding|IEA; GO:0005618|cell wall|IEA; GO:0005737|cytoplasm|IEA; GO:0008763|UDP-N-acetylmuramate-L-alanine ligase activity|IEA; GO:0009058|biosynthesis|IEA; GO:0009252|peptidoglycan biosynthesis|IEA; GO:0009273|cell wall biosynthesis (sensu Bacteria)|IEA; GO:0016874|ligase activity|IEA

RP248

MURB

UDP-N-acetylenolpyruvoylglucosamine reductase related cluster

1461

1e-162

95% (283/295)

1.1.1.158

Cell wall/membrane/envelope biogenesis

Aminosugars metabolism

GO:0000910|cytokinesis|IEA; GO:0005618|cell wall|IEA; GO:0006118|electron transport|IEA; GO:0008762|UDP-N-acetylmuramate dehydrogenase activity|IEA; GO:0009252|peptidoglycan biosynthesis|IEA; GO:0016491|oxidoreductase activity|IEA

RP249

DDL

D-alanine--D-alanine ligase related cluster

1652

0.0

100% (321/321)

6.3.2.4

Cell wall/membrane/envelope biogenesis

D-Alanine metabolism Peptidoglycan biosynthesis

GO:0005618|cell wall|IEA; GO:0005737|cytoplasm|IEA; GO:0008716|D-alanine-D-alanine ligase activity|IEA; GO:0009252|peptidoglycan biosynthesis|IEA; GO:0016874|ligase activity|IEA

RP250

ftsQ

Cell division protein ftsQ homolog related cluster

1252

1e-138

100% (247/247)

Cell wall/membrane/envelope biogenesis

GO:0000910|cytokinesis|IEA; GO:0000917|barrier septum formation|IEA; GO:0016021|integral to membrane|IEA; GO:0019866|inner membrane|IEA

RP251

ftsA

Cell division protein FtsA related cluster

1992

0.0

95% (392/411)

Cell cycle control, cell division, chromosome partitioning

GO:0000910|cytokinesis|IEA; GO:0007049|cell cycle|IEA

RP253

cycM

Cytochrome c related cluster

828

2e-88

91% (160/175)

Energy production and conversion

GO:0005489|electron transporter activity|IEA; GO:0006118|electron transport|IEA

RP254

lpxC

UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase related cluster

1487

1e-165

100% (288/288)

3.5.1.-

Cell wall/membrane/envelope biogenesis

Lipopolysaccharide biosynthesis

GO:0008610|lipid biosynthesis|IEA; GO:0008759|UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity|IEA; GO:0009245|lipid A biosynthesis|IEA; GO:0016787|hydrolase activity|IEA

RP256

rne

Ribonuclease E related cluster

3053

0.0

90% (616/681)

3.1.4.-

Translation, ribosomal structure and biogenesis

Aminosugars metabolism

GO:0016787|hydrolase activity|IEA

RP257

coxW

CYTOCHROME C OXIDASE ASSEMBLY PROTEI related cluster

1439

1e-159

84% (283/334)

Posttranslational modification, protein turnover, chaperones

Oxidative phosphorylation

GO:0006461|protein complex assembly|IEA; GO:0016020|membrane|IEA

RP259

pbpE

Penicillin binding protein 4* related cluster

2048

0.0

96% (398/414)

Defense mechanisms

GO:0046677|response to antibiotic|IEA

RP260

xthA1

Exodeoxyribonuclease III related cluster

1283

1e-141

91% (238/261)

3.1.11.2

Replication, recombination and repair

GO:0008853|exodeoxyribonuclease III activity|IEA; GO:0016787|hydrolase activity|IEA

RP261

ODPA

Pyruvate dehydrogenase E1 component, alpha subunit related cluster

1612

1e-180

100% (309/309)

1.2.4.1

Energy production and conversion

Butanoate metabolism Glycolysis / Gluconeogenesis Pyruvate metabolism Valine, leucine and isoleucine biosynthesis

GO:0004739|pyruvate dehydrogenase (acetyl-transferring) activity|IEA; GO:0006096|glycolysis|IEA; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0016624|oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor|IEA

RP262

ODPB

Pyruvate dehydrogenase E1 component, beta subunit related cluster

1490

1e-165

88% (288/326)

1.2.4.1

Energy production and conversion

Butanoate metabolism Glycolysis / Gluconeogenesis Pyruvate metabolism Valine, leucine and isoleucine biosynthesis

GO:0004739|pyruvate dehydrogenase (acetyl-transferring) activity|IEA; GO:0006096|glycolysis|IEA; GO:0016491|oxidoreductase activity|IEA

RP265

IDH

Isocitrate dehydrogenase [NADP] related cluster

2277

0.0

90% (437/483)

1.1.1.42

GO:0004450|isocitrate dehydrogenase (NADP+) activity|IEA; GO:0006097|glyoxylate cycle|IEA; GO:0006099|tricarboxylic acid cycle|IEA; GO:0008152|metabolism|IEA; GO:0016491|oxidoreductase activity|IEA

RP268

ccmB

Heme exporter protein B related cluster

794

3e-84

74% (160/215)

RP270

UCRI

Ubiquinol-cytochrome c reductase iron-sulfur subunit related cluster

878

3e-94

93% (165/177)

1.10.2.2

Oxidative phosphorylation

GO:0006118|electron transport|IEA; GO:0008121|ubiquinol-cytochrome-c reductase activity|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0019866|inner membrane|IEA; GO:0045285|ubiquinol-cytochrome-c reductase complex|IEA

RP271

petB

Cytochrome b related cluster

1989

0.0

92% (370/398)

1.10.2.2

Energy production and conversion

Oxidative phosphorylation

GO:0005746|mitochondrial electron transport chain|IEA; GO:0006118|electron transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016491|oxidoreductase activity|IEA

RP272

fbcH

CYTOCHROME C1, HEME PROTEIN related cluster

1283

1e-141

94% (240/253)

1.10.2.2

Energy production and conversion

Oxidative phosphorylation

GO:0005489|electron transporter activity|IEA; GO:0005746|mitochondrial electron transport chain|IEA; GO:0006118|electron transport|IEA

RP273

HSP22-like heat shock protein related cluster

698

3e-73

82% (135/163)

Posttranslational modification, protein turnover, chaperones

GO:0006457|protein folding|IEA; GO:0006986|response to unfolded protein|IEA

RP275

lepA

GTP-binding protein lepA related cluster

2728

0.0

88% (532/600)

Cell wall/membrane/envelope biogenesis

GO:0003746|translation elongation factor activity|IEA; GO:0005525|GTP binding|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006414|translational elongation|IEA

RP280

rodA

ROD SHAPE-DETERMINING PROTEIN RODA related cluster

1565

1e-174

84% (323/383)

GO:0007049|cell cycle|IEA; GO:0016021|integral to membrane|IEA

RP281

Oligopeptidase B related cluster

3420

0.0

93% (637/684)

GO:0004252|serine-type endopeptidase activity|IEA; GO:0004287|prolyl oligopeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0008236|serine-type peptidase activity|IEA; GO:0008945|oligopeptidase B activity|IEA; GO:0016787|hydrolase activity|IEA

RP282

HyfB domain containing protein related cluster

1821

0.0

74% (380/512)

1.6.5.3

Oxidative phosphorylation Ubiquinone biosynthesis

GO:0008137|NADH dehydrogenase (ubiquinone) activity|IEA; GO:0016021|integral to membrane|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0042773|ATP synthesis coupled electron transport|IEA

RP283

NADH dehydrogenase I chain L [EC:1.6.5.3] related cluster

1810

0.0

77% (375/486)

1.6.5.3

Oxidative phosphorylation Ubiquinone biosynthesis

GO:0008137|NADH dehydrogenase (ubiquinone) activity|IEA; GO:0016021|integral to membrane|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0042773|ATP synthesis coupled electron transport|IEA

RP284

NADH DEHYDROGENASE I CHAIN N related cluster

1677

0.0

81% (352/432)

GO:0008137|NADH dehydrogenase (ubiquinone) activity|IEA; GO:0016021|integral to membrane|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0042773|ATP synthesis coupled electron transport|IEA

RP286

trbG

Probable conjugal transfer protein trbG related cluster

1181

1e-129

90% (227/250)

Type IV secretion system

RP287

VIRB8 PROTEIN related cluster

1047

1e-114

85% (212/247)

Intracellular trafficking, secretion, and vesicular transport

Type IV secretion system

RP290

virB9

VirB9 protein of the type IV secretion system related cluster

765

5e-81

94% (149/157)

Intracellular trafficking, secretion, and vesicular transport

Type IV secretion system

RP291

virB10

VIRB10 PROTEIN related cluster

2016

0.0

85% (413/483)

Intracellular trafficking, secretion, and vesicular transport

Type IV secretion system

GO:0009291|unidirectional conjugation|IEA

RP292

virB11

VIRB11 PROTEIN related cluster

1575

1e-175

94% (316/334)

Type IV secretion system

GO:0005524|ATP binding|IEA; GO:0005622|intracellular|IEA; GO:0006810|transport|IEA

RP293

virD4

VIRD4 PROTEIN related cluster

3002

0.0

97% (577/591)

Intracellular trafficking, secretion, and vesicular transport

Type IV secretion system

GO:0009291|unidirectional conjugation|IEA; GO:0016020|membrane|IEA

RP376

MDH

Malate dehydrogenase related cluster

1402

1e-155

91% (287/314)

1.1.1.37

Energy production and conversion

Carbon fixation Citrate cycle (TCA cycle) Glyoxylate and dicarboxylate metabolism Pyruvate metabolism Reductive carboxylate cycle (CO2 fixation)

GO:0004459|L-lactate dehydrogenase activity|IEA; GO:0006096|glycolysis|IEA; GO:0006099|tricarboxylic acid cycle|IEA; GO:0006100|tricarboxylic acid cycle intermediate metabolism|IEA; GO:0016491|oxidoreductase activity|IEA; GO:0030060|L-malate dehydrogenase activity|IEA

RP377

tlcB

ADP,ATP carrier protein 2 related cluster

2452

0.0

94% (479/507)

Energy production and conversion

GO:0005471|ATP:ADP antiporter activity|IEA; GO:0005524|ATP binding|IEA; GO:0006810|transport|IEA; GO:0016021|integral to membrane|IEA

RP378

PYRG

CTP synthase related cluster

2960

0.0

97% (573/586)

6.3.4.2

Nucleotide transport and metabolism

Pyrimidine metabolism

GO:0003824|catalytic activity|IEA; GO:0003883|CTP synthase activity|IEA; GO:0006221|pyrimidine nucleotide biosynthesis|IEA; GO:0006541|glutamine metabolism|IEA; GO:0016874|ligase activity|IEA

RP379

KDSB

3-deoxy-manno-octulosonate cytidylyltransferase related cluster

1089

1e-119

91% (224/246)

2.7.7.38

Cell wall/membrane/envelope biogenesis

Lipopolysaccharide biosynthesis

GO:0005737|cytoplasm|IEA; GO:0008690|3-deoxy-manno-octulosonate cytidylyltransferase activity|IEA; GO:0009103|lipopolysaccharide biosynthesis|IEA; GO:0016740|transferase activity|IEA; GO:0016779|nucleotidyltransferase activity|IEA

RP383

GCH1

GTP cyclohydrolase I related cluster

980

1e-106

100% (190/190)

3.5.4.16

Coenzyme transport and metabolism

Folate biosynthesis

GO:0003934|GTP cyclohydrolase I activity|IEA; GO:0006730|one-carbon compound metabolism|IEA; GO:0009058|biosynthesis|IEA; GO:0016787|hydrolase activity|IEA; GO:0046654|tetrahydrofolate biosynthesis|IEA

RP384

SYP

Prolyl-tRNA synthetase related cluster

2262

0.0

100% (432/432)

6.1.1.15

Translation, ribosomal structure and biogenesis

GO:0004812|tRNA ligase activity|IEA; GO:0004827|proline-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0005737|cytoplasm|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006418|tRNA aminoacylation for protein translation|IEA; GO:0006433|prolyl-tRNA aminoacylation|IEA; GO:0016874|ligase activity|IEA

RP385

ruvA

Holliday junction DNA helicase ruvA related cluster

990

1e-107

100% (199/199)

Replication, recombination and repair

GO:0003677|DNA binding|IEA; GO:0003678|DNA helicase activity|IEA; GO:0004386|helicase activity|IEA; GO:0005622|intracellular|IEA; GO:0006281|DNA repair|IEA; GO:0006310|DNA recombination|IEA; GO:0009378|Holliday junction helicase activity|IEA; GO:0009432|SOS response|IEA

RP386

ruvB

Holliday junction DNA helicase ruvB related cluster

1483

1e-165

88% (293/331)

Replication, recombination and repair

GO:0000166|nucleotide binding|IEA; GO:0003677|DNA binding|IEA; GO:0004386|helicase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006281|DNA repair|IEA; GO:0006310|DNA recombination|IEA; GO:0009378|Holliday junction helicase activity|IEA; GO:0009432|SOS response|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA

RP387

msbA1

Lipid A export ATP-binding/permease protein MsbA related cluster

112

0.0

100% (20/20)

Defense mechanisms

GO:0000166|nucleotide binding|IEA; GO:0005524|ATP binding|IEA; GO:0006810|transport|IEA; GO:0016021|integral to membrane|IEA; GO:0016887|ATPase activity|IEA; GO:0017111|nucleoside-triphosphatase activity|IEA; GO:0042626|ATPase activity, coupled to transmembrane movement of substances|IEA

RP389

dacF

Serine-type D-Ala-D-Ala carboxypeptidase related cluster

1343

1e-148

92% (262/282)

3.4.16.4

Cell wall/membrane/envelope biogenesis

GO:0004180|carboxypeptidase activity|IEA; GO:0004185|serine carboxypeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0009002|serine-type D-Ala-D-Ala carboxypeptidase activity|IEA; GO:0016787|hydrolase activity|IEA; GO:0046677|response to antibiotic|IEA

RP397

tlpA

THIOL:DISULFIDE INTERCHANGE PROTEIN TLPA related cluster

1085

1e-118

93% (206/221)

GO:0005489|electron transporter activity|IEA; GO:0006118|electron transport|IEA

RP398

POSSIBLE PROTEASE SOHB related cluster

1324

1e-146

86% (267/308)

GO:0006508|proteolysis and peptidolysis|IEA; GO:0008233|peptidase activity|IEA

RP399

DUT

Deoxyuridine 5'-triphosphate nucleotidohydrolase related cluster

736

1e-77

100% (148/148)

3.6.1.23

Pyrimidine metabolism

GO:0004170|dUTP diphosphatase activity|IEA; GO:0006220|pyrimidine nucleotide metabolism|IEA; GO:0009117|nucleotide metabolism|IEA; GO:0016787|hydrolase activity|IEA; GO:0046080|dUTP metabolism|IEA

RP400

Soluble lytic transglycosylase domain containing protein related cluster

3024

0.0

90% (571/631)

3.2.1.-

Cell wall/membrane/envelope biogenesis

Aminosugars metabolism Glycosaminoglycan degradation Nucleotide sugars metabolism

RP405

coxA

Cytochrome c oxidase polypeptide I [EC:1.9.3.1] related cluster

2496

0.0

91% (463/507)

1.9.3.1

Energy production and conversion

Oxidative phosphorylation

GO:0004129|cytochrome-c oxidase activity|IEA; GO:0005746|mitochondrial electron transport chain|IEA; GO:0006118|electron transport|IEA; GO:0006810|transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016491|oxidoreductase activity|IEA

RP406

COX2

Probable cytochrome c oxidase polypeptide II related cluster

1546

1e-172

93% (294/313)

1.9.3.1

Energy production and conversion

Oxidative phosphorylation

GO:0004129|cytochrome-c oxidase activity|IEA; GO:0005507|copper ion binding|IEA; GO:0005746|mitochondrial electron transport chain|IEA; GO:0006118|electron transport|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016491|oxidoreductase activity|IEA

RP408

LSPA

Lipoprotein signal peptidase related cluster

1026

1e-111

100% (194/194)

3.4.23.36

Protein export

GO:0004190|aspartic-type endopeptidase activity|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0009005|signal peptidase II activity|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016787|hydrolase activity|IEA; GO:0019866|inner membrane|IEA

RP410

MURD

UDP-N-acetylmuramoylalanine--D-glutamate ligase related cluster

2192

0.0

96% (431/445)

6.3.2.9

Cell wall/membrane/envelope biogenesis

D-Glutamine and D-glutamate metabolism Peptidoglycan biosynthesis

GO:0000910|cytokinesis|IEA; GO:0005524|ATP binding|IEA; GO:0005618|cell wall|IEA; GO:0005737|cytoplasm|IEA; GO:0008764|UDP-N-acetylmuramoylalanine-D-glutamate ligase activity|IEA; GO:0009058|biosynthesis|IEA; GO:0009252|peptidoglycan biosynthesis|IEA; GO:0009273|cell wall biosynthesis (sensu Bacteria)|IEA; GO:0016874|ligase activity|IEA

RP411

ftsW

Cell division protein ftsW related cluster

1679

0.0

87% (330/377)

Cell cycle control, cell division, chromosome partitioning

GO:0000910|cytokinesis|IEA; GO:0007049|cell cycle|IEA; GO:0016021|integral to membrane|IEA

RP412

MURG

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase related cluster

1946

0.0

100% (385/385)

2.4.1.227

Cell wall/membrane/envelope biogenesis

Peptidoglycan biosynthesis

GO:0000910|cytokinesis|IEA; GO:0005618|cell wall|IEA; GO:0005975|carbohydrate metabolism|IEA; GO:0009252|peptidoglycan biosynthesis|IEA; GO:0016020|membrane|IEA; GO:0016740|transferase activity|IEA; GO:0016757|transferase activity, transferring glycosyl groups|IEA; GO:0016758|transferase activity, transferring hexosyl groups|IEA; GO:0019277|UDP-N-acetylgalactosamine biosynthesis|IEA; GO:0019866|inner membrane|IEA; GO:0030246|carbohydrate binding|IEA; GO:0030259|lipid glycosylation|IEA; GO:0050511|undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity|IEA

RP414

Glycosyltransferase related cluster

1614

1e-180

92% (314/338)

Cell wall/membrane/envelope biogenesis

GO:0009058|biosynthesis|IEA; GO:0016740|transferase activity|IEA

RP415

DAPF

Diaminopimelate epimerase related cluster

1340

1e-148

95% (257/270)

5.1.1.7

Amino acid transport and metabolism

Lysine biosynthesis

GO:0008837|diaminopimelate epimerase activity|IEA; GO:0009085|lysine biosynthesis|IEA; GO:0009089|lysine biosynthesis via diaminopimelate|IEA; GO:0016853|isomerase activity|IEA

RP417

SYFA

Phenylalanyl-tRNA synthetase alpha chain related cluster

1707

0.0

93% (326/350)

6.1.1.20

Translation, ribosomal structure and biogenesis

Aminoacyl-tRNA biosynthesis Phenylalanine, tyrosine and tryptophan biosynthesis

GO:0000287|magnesium ion binding|IEA; GO:0004812|tRNA ligase activity|IEA; GO:0004826|phenylalanine-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0005737|cytoplasm|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006418|tRNA aminoacylation for protein translation|IEA; GO:0006432|phenylalanyl-tRNA aminoacylation|IEA; GO:0016874|ligase activity|IEA

RP418

SYFB

Phenylalanyl-tRNA synthetase beta chain related cluster

4033

0.0

97% (794/815)

6.1.1.20

Translation, ribosomal structure and biogenesis

Aminoacyl-tRNA biosynthesis Phenylalanine, tyrosine and tryptophan biosynthesis

GO:0000049|tRNA binding|IEA; GO:0000287|magnesium ion binding|IEA; GO:0003723|RNA binding|IEA; GO:0004812|tRNA ligase activity|IEA; GO:0004826|phenylalanine-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006432|phenylalanyl-tRNA aminoacylation|IEA; GO:0016874|ligase activity|IEA

RP419

DPO3B

DNA polymerase III, beta chain related cluster

1882

0.0

100% (381/381)

2.7.7.7

Replication, recombination and repair

DNA polymerase Purine metabolism Pyrimidine metabolism

GO:0003677|DNA binding|IEA; GO:0003887|DNA-directed DNA polymerase activity|IEA; GO:0006260|DNA replication|IEA; GO:0008408|3'-5' exonuclease activity|IEA; GO:0016740|transferase activity|IEA

RP421

SYL

Leucyl-tRNA synthetase related cluster

4322

0.0

100% (812/812)

6.1.1.4

Translation, ribosomal structure and biogenesis

GO:0004812|tRNA ligase activity|IEA; GO:0004823|leucine-tRNA ligase activity|IEA; GO:0005524|ATP binding|IEA; GO:0006412|protein biosynthesis|IEA; GO:0006418|tRNA aminoacylation for protein translation|IEA; GO:0006429|leucyl-tRNA aminoacylation|IEA; GO:0016874|ligase activity|IEA

RP424

CDSA

Phosphatidate cytidylyltransferase related cluster

999

1e-108

87% (199/228)

2.7.7.41

GO:0004605|phosphatidate cytidylyltransferase activity|IEA; GO:0008654|phospholipid biosynthesis|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016740|transferase activity|IEA; GO:0016779|nucleotidyltransferase activity|IEA

RP426

envZ

OSMOLARITY SENSOR PROTEIN ENVZ related cluster

1947

0.0

90% (396/437)

2.7.3.-

GO:0000155|two-component sensor molecule activity|IEA; GO:0004871|signal transducer activity|IEA; GO:0005524|ATP binding|IEA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0007165|signal transduction|IEA; GO:0007600|sensory perception|IEA; GO:0016020|membrane|IEA; GO:0016021|integral to membrane|IEA; GO:0016301|kinase activity|IEA; GO:0016310|phosphorylation|IEA; GO:0016740|transferase activity|IEA; GO:0016772|transferase activity, transferring phosphorus-containing groups|IEA