| Annotation Name | Serine/threonine protein kinase/endoribonuclease IRE1 precursor (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine protein kinase (EC 2.7.1.37); Endoribonuclease (EC 3.1.26.-)] related cluster |
| Score | 5150&emsp |
| E-value | 0.0 |
| % Sequence Identity | 91% (1003/1100) |
| Locus | IRE1 |
| EC Number | 2.7.1.37 |
| COG Function | |
| KEGG Pathway | |
| Source | Accession | Description | Score | E-value | % Sequence Identity | Locus | EC Number | Informative Hit | Function/Pathway | GeneOntology |
| uniref90 | UniRef90_P32361 | Serine/threonine protein kinase/endoribonuclease IRE1 precursor (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine protein kinase (EC 2.7.1.37); Endoribonuclease (EC 3.1.26.-)] related cluster | 5150 | 0.0 | 91% (1003/1100) | IRE1 | 2.7.1.37 | 1 | | GO:0000287|magnesium ion binding|IEA; GO:0003824|catalytic activity|IEA; GO:0004521|endoribonuclease activity|TAS; GO:0004672|protein kinase activity|IEA; GO:0004674|protein serine/threonine kinase activity|IDA; GO:0004674|protein serine/threonine kinase activity|IEA; GO:0005524|ATP binding|IEA; GO:0005635|nuclear membrane|TAS; GO:0005783|endoplasmic reticulum|IEA; GO:0005789|endoplasmic reticulum membrane|TAS; GO:0006020|myo-inositol metabolism|TAS; GO:0006118|electron transport|IEA; GO:0006355|regulation of transcription, DNA-dependent|IEA; GO:0006468|protein amino acid phosphorylation|IDA; GO:0006468|protein amino acid phosphorylation|IEA; GO:0006986|response to unfolded protein|IEA; GO:0006987|unfolded protein response, activation of signaling protein activity|TAS; GO:0016021|integral to membrane|IEA; GO:0016740|transferase activity|IEA; GO:0030969|UFP-specific transcription factor mRNA processing during unfolded protein response|TAS |
| nr | EAK98642 | likely protein kinase/endoribonuclease Ire1 [Candida albicans SC5314] | 474 | 2e-45 | 32% (131/397) | | | 8 | | |
| cog | YHR079c_1 | | 2911 | 0.0 | 87% (572/656) | | | 0 | | |
| kegg | cal:orf19.5068 | IRE1; protein kinase [EC:2.7.1.37] | 474 | 9e-46 | 32% (131/397) | IRE1 | 2.7.1.37 | 3 | | |
| smart | 00220 | smart00220, S_TKc, Serine/Threonine protein kinases, catalytic domain; Phosphotransferases | 440 | 7e-45 | 28% (87/310) | S_TKc | | 1 | | |
| smart2 | 00219 | smart00219, TyrKc, Tyrosine kinase, catalytic domain; Phosphotransferases | 259 | 6e-24 | 23% (73/310) | TyrKc | | 2 | | |
| smart3 | 00580 | smart00580, PUG, domain in protein kinases, N-glycanases and other nuclear proteins; | 174 | 5e-14 | 48% (28/58) | PUG | | 3 | | |
| pfam | PF06479 | pfam06479, Ribonuc_2-5A, Ribonuclease 2-5A | 479 | 6e-48 | 51% (67/131) | Ribonuc_2-5A | | 1 | | |
| pfam2 | PF00069 | pfam00069, Pkinase, Protein kinase domain | 418 | 7e-41 | 28% (90/316) | Pkinase | | 2 | | |