| pfam8 | PF02695 | pfam02695, DUF216, Domain of unknown function DUF | 136 | 6e-08 | 16% (40/244) | DUF216 | | 7 | | |
| pfam9 | PF01594 | pfam01594, UPF0118, Domain of unknown function DUF20 | 141 | 2e-08 | 18% (58/314) | UPF0118 | | 8 | | |
| pfam10 | PF03631 | pfam03631, Ribonuclease_BN, Ribonuclease BN-like family | 140 | 2e-08 | 19% (52/264) | Ribonuclease_BN | | 9 | | |
| Annotation Name | Twinkle related cluster |
| Score | 152&emsp |
| E-value | 6e-08 |
| % Sequence Identity | 38% (34/89) |
| Locus | |
| EC Number | |
| COG Function | |
| KEGG Pathway | |
| Source | Accession | Description | Score | E-value | % Sequence Identity | Locus | EC Number | Informative Hit | Function/Pathway | GeneOntology |
| uniref90 | UniRef90_Q8CIW5 | Twinkle related cluster | 152 | 6e-08 | 38% (34/89) | | | 7 | | GO:0003678|DNA helicase activity|IDA; GO:0005739|mitochondrion|IDA; GO:0006268|DNA unwinding|IDA |
| nr | ZP_00097788 | COG0749: DNA polymerase I - 3'-5' exonuclease and polymerase domains [Desulfitobacterium hafniense DCB-2] | 642 | 1e-64 | 30% (175/569) | | | 8 | | |
| cog | aq_1967 | [L] COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains | 538 | 4e-54 | 31% (172/547) | | | 1 | Replication, recombination and repair | |
| kegg | cme:CMT452C | twinkle (putative T7 phage-type DNA helicase for mitochondrial DNA) | 381 | 5e-35 | 30% (107/351) | | | 2 | | |
| smart | 00482 | smart00482, POLAc, DNA polymerase A domain; | 392 | 4e-39 | 32% (67/209) | POLAc | | 1 | | |
| smart2 | 00474 | smart00474, 35EXOc, 3'-5' exonuclease; 3\' -5' exonuclease proofreading domain present in DNA polymerase I, Werner syndrome helicase, RNase D and other enzymes | 293 | 1e-27 | 35% (59/165) | 35EXOc | | 2 | | |
| smart3 | 00486 | smart00486, POLBc, DNA polymerase type-B family; DNA polymerase alpha, delta, epsilon and zeta chain (eukaryota), DNA polymerases in archaea, DNA polymerase II in e | 108 | 3e-06 | 14% (63/443) | POLBc | | 3 | | |
| smart4 | 00730 | smart00730, PSN, Presenilin, signal peptide peptidase, family; Presenilin 1 and presenilin 2 are polytopic membrane proteins, whose genes are mutated in some individuals with Alzheimer's disease | 94 | 1e-04 | 18% (59/323) | PSN | | 4 | | |
| pfam | PF00476 | pfam00476, DNA_pol_A, DNA polymerase family A | 503 | 2e-50 | 33% (106/315) | DNA_pol_A | | 1 | | |
| pfam2 | PF06636 | pfam06636, DUF1157, Protein of unknown function (DUF1157) | 134 | 1e-07 | 22% (89/393) | DUF1157 | | 10 | | |
| pfam3 | PF01612 | pfam01612, 3_5_exonuc, 3'-5' exonuclease | 299 | 8e-27 | 34% (62/178) | 3_5_exonuc | | 2 | | |
| pfam4 | PF02414 | pfam02414, Borrelia_orfA, Borrelia ORF-A | 163 | 5e-11 | 21% (78/367) | Borrelia_orfA | | 3 | | |
| pfam5 | PF05316 | pfam05316, VAR1, Mitochondrial ribosomal protein (VAR1) | 162 | 6e-11 | 26% (100/372) | VAR1 | | 4 | | |
| pfam6 | PF03125 | pfam03125, Sre, C | 134 | 1e-07 | 14% (53/359) | Sre | | 5 | | |
| pfam7 | PF01604 | pfam01604, 7tm_5, 7TM chemoreceptor | 122 | 3e-06 | 16% (34/202) | 7tm_5 | | 6 | | |