Detailed annotation info for ENST00000362035; Protein-S-isoprenylcysteine O-methyltransferase (EC 2.1.1.100) (Isoprenylcysteine carboxylmethyltransferase) (Prenylcysteine carboxyl methyltransferase) (pcCMT) (Prenylated protein carboxyl methyltransferase) (PPMT). [Source:Uniprot/SWISSPROT;Acc:O60725]
Annotation NameProtein-S-isoprenylcysteine O-methyltransferase related cluster
Score1303&emsp
E-value1e-143
% Sequence Identity90% (246/273)
LocusICMT
EC Number2.1.1.100
COG Function Posttranslational modification, protein turnover, chaperones
KEGG Pathway
SourceAccessionDescriptionScoreE-value% Sequence IdentityLocusEC NumberInformative HitFunction/PathwayGeneOntology
uniref90UniRef90_O60725Protein-S-isoprenylcysteine O-methyltransferase related cluster13031e-14390% (246/273)ICMT2.1.1.1001GO:0003880|C-terminal protein carboxyl methyltransferase activity|TAS; GO:0004671|protein-S-isoprenylcysteine O-methyltransferase activity|IEA; GO:0005624|membrane fraction|TAS; GO:0005783|endoplasmic reticulum|IEA; GO:0005783|endoplasmic reticulum|TAS; GO:0006464|protein modification|TAS; GO:0006481|C-terminal protein amino acid methylation|IEA; GO:0006481|C-terminal protein amino acid methylation|TAS; GO:0006612|protein-membrane targeting|TAS; GO:0008168|methyltransferase activity|IEA; GO:0016021|integral to membrane|IEA; GO:0016740|transferase activity|IEA
nrXP_546748PREDICTED: similar to Protein-S-isoprenylcysteine O-methyltransferase (Isoprenylcysteine carboxylmethyltransferase) (Prenylcysteine carboxyl methyltransferase) (pcCMT) (Prenylated protein carboxyl methyltransferase) (PPMT) [Canis familiaris]12701e-13787% (238/273)2
cogYDR410c[O] COG2020 Putative protein-S-isoprenylcysteine methyltransferase4684e-4642% (92/218)1 Posttranslational modification, protein turnover, chaperones
keggmmu:57295Icmt; isoprenylcysteine carboxyl methyltransferase [EC:2.1.1.100]12591e-13886% (236/273)Icmt2.1.1.1002
smartNo hits found0
pfamPF04140pfam04140, ICMT, Isoprenylcysteine carboxyl methyltransferase (ICMT) family3238e-3039% (38/96)ICMT1