Detailed annotation info for ENST00000361827; Mannan-binding lectin serine protease 2 precursor (EC 3.4.21.-) (Mannose-binding protein associated serine protease 2) (MASP-2) (MBL- associated serine protease 2). [Source:Uniprot/SWISSPROT;Acc:O00187]
Annotation NameMannan-binding lectin serine protease 2 precursor related cluster
Score960&emsp
E-value1e-103
% Sequence Identity95% (173/181)
LocusMasp2
EC Number
COG Function
KEGG Pathway Complement and coagulation cascades
SourceAccessionDescriptionScoreE-value% Sequence IdentityLocusEC NumberInformative HitFunction/PathwayGeneOntology
uniref90UniRef90_O00187Mannan-binding lectin serine protease 2 precursor related cluster9601e-10395% (173/181)1GO:0004252|serine-type endopeptidase activity|IEA; GO:0004252|serine-type endopeptidase activity|TAS; GO:0004263|chymotrypsin activity|IEA; GO:0004295|trypsin activity|IEA; GO:0005509|calcium ion binding|IEA; GO:0005576|extracellular region|IEA; GO:0006508|proteolysis and peptidolysis|IEA; GO:0006956|complement activation|IEA; GO:0006956|complement activation|TAS; GO:0006958|complement activation, classical pathway|IEA; GO:0008233|peptidase activity|IEA; GO:0008236|serine-type peptidase activity|TAS; GO:0016787|hydrolase activity|IEA; GO:0019735|antimicrobial humoral response (sensu Vertebrata)|TAS
nr1SZBChain B, Crystal Structure Of The Human Mbl-Associated Protein 19 (Map19) pdb|1SZB|A Chain A, Crystal Structure Of The Human Mbl-Associated Protein 19 (Map19)9481e-101100% (170/170)8
cogNo hits found0
keggmmu:17175Masp2; mannan-binding lectin serine protease 2 [KO:K03993]7772e-8281% (137/168)Masp22 Complement and coagulation cascades
smart00042smart00042, CUB, Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein2492e-2340% (46/113)CUB1
smart200179smart00179, EGF_CA, Calcium-binding EGF-like domain;1051e-0632% (15/46)EGF_CA2
smart300181smart00181, EGF, Epidermal growth factor-like domain898e-0527% (10/37)EGF3
pfamPF00431pfam00431, CUB, CUB domain1985e-1635% (39/111)CUB1
pfam2PF05955pfam05955, Herpes_gp2, Equine herpesvirus glycoprotein gp21001e-0423% (47/201)Herpes_gp22