| pfam8 | PF04094 | pfam04094, DUF390, Protein of unknown function (DUF390) | 115 | 1e-05 | 25% (88/350) | DUF390 | | 7 | | |
| pfam9 | PF05956 | pfam05956, APC_basic, APC basic domain | 108 | 7e-05 | 23% (86/372) | APC_basic | | 8 | | |
| smart5 | 00144 | smart00144, PI3K_rbd, PI3-kinase family, Ras-binding domain; Certain members of the PI3K family possess Ras-binding domains in their N-termini | 129 | 9e-09 | 30% (24/78) | PI3K_rbd | | 5 | | |
| pfam10 | PF06873 | pfam06873, SerH, Cell surface immobilisation antigen SerH | 108 | 7e-05 | 19% (62/320) | SerH | | 9 | | |
| Annotation Name | Phosphatidylinositol 3-kinase delta catalytic subunit related cluster |
| Score | 5011&emsp |
| E-value | 0.0 |
| % Sequence Identity | 90% (964/1068) |
| Locus | Pik3cd |
| EC Number | 2.7.1.153 |
| COG Function | |
| KEGG Pathway | Apoptosis Inositol phosphate metabolism Jak-STAT signaling pathway Phosphatidylinositol signaling system Regulation of actin cytoskeleton Toll-like receptor signaling pathway |
| Source | Accession | Description | Score | E-value | % Sequence Identity | Locus | EC Number | Informative Hit | Function/Pathway | GeneOntology |
| uniref90 | UniRef90_O00334 | Phosphatidylinositol 3-kinase delta catalytic subunit related cluster | 5011 | 0.0 | 90% (964/1068) | | | 1 | | GO:0004428|inositol or phosphatidylinositol kinase activity|IEA; GO:0005942|phosphoinositide 3-kinase complex|IEA; GO:0007165|signal transduction|IEA; GO:0016301|kinase activity|IEA; GO:0016303|phosphatidylinositol 3-kinase activity|IEA; GO:0016773|phosphotransferase activity, alcohol group as acceptor|IEA |
| nr | AAB53966 | phosphatidylinositol 3-kinase delta catalytic subunit | 5011 | 0.0 | 90% (964/1069) | | | 2 | | |
| cog | SPAC458.05 | [TDBLU] COG5032 Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family | 558 | 1e-56 | 30% (154/504) | | | 1 | | |
| kegg | mmu:18707 | Pik3cd; phosphatidylinositol 3-kinase catalytic delta polypeptide [EC:2.7.1.153] [KO:K00922] | 4223 | 0.0 | 78% (839/1068) | Pik3cd | 2.7.1.153 | 1 | Apoptosis Inositol phosphate metabolism Jak-STAT signaling pathway Phosphatidylinositol signaling system Regulation of actin cytoskeleton Toll-like receptor signaling pathway | |
| smart | 00146 | smart00146, PI3Kc, Phosphoinositide 3-kinase, catalytic domain; Phosphoinositide 3-kinase isoforms participate in a variety of processes, including cell motility, the Ras pathway, vesicle trafficking and secretion, and apoptosis | 717 | 6e-77 | 39% (114/291) | PI3Kc | | 1 | | |
| smart2 | 00145 | smart00145, PI3Ka, Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases | 610 | 1e-64 | 50% (93/185) | PI3Ka | | 2 | | |
| smart3 | 00142 | smart00142, PI3K_C2, Phosphoinositide 3-kinase, region postulated to contain C2 domain; Outlier of C2 family | 233 | 8e-21 | 36% (35/97) | PI3K_C2 | | 3 | | |
| smart4 | 00143 | smart00143, PI3K_p85B, PI3-kinase family, p85-binding domain; Region of p110 PI3K that binds the p85 subunit | 219 | 3e-19 | 44% (35/78) | PI3K_p85B | | 4 | | |
| pfam | PF00454 | pfam00454, PI3_PI4_kinase, Phosphatidylinositol 3- and 4-kinase | 579 | 2e-59 | 38% (90/236) | PI3_PI4_kinase | | 1 | | |
| pfam2 | PF03251 | pfam03251, Tymo_45kd_70kd, Tymovirus 45/70Kd protein | 106 | 1e-04 | 23% (53/230) | Tymo_45kd_70kd | | 10 | | |
| pfam3 | PF00613 | pfam00613, PI3Ka, Phosphoinositide 3-kinase family, accessory domain (PIK domain) | 524 | 4e-53 | 47% (86/182) | PI3Ka | | 2 | | |
| pfam4 | PF00792 | pfam00792, PI3K_C2, Phosphoinositide 3-kinase C2 | 290 | 6e-26 | 30% (43/141) | PI3K_C2 | | 3 | | |
| pfam5 | PF00794 | pfam00794, PI3K_rbd, PI3-kinase family, ras-binding domain | 234 | 2e-19 | 41% (36/87) | PI3K_rbd | | 4 | | |
| pfam6 | PF02192 | pfam02192, PI3K_p85B, PI3-kinase family, p85-binding domain | 219 | 1e-17 | 44% (35/78) | PI3K_p85B | | 5 | | |
| pfam7 | PF03154 | pfam03154, Atrophin-1, Atrophin-1 family | 131 | 2e-07 | 25% (81/320) | Atrophin-1 | | 6 | | |