| pfam8 | PF04094 | pfam04094, DUF390, Protein of unknown function (DUF390) | 118 | 5e-06 | 24% (77/316) | DUF390 | | 7 | | |
| pfam9 | PF05518 | pfam05518, Totivirus_coat, Totivirus coat protein | 116 | 9e-06 | 26% (51/193) | Totivirus_coat | | 8 | | |
| smart5 | 00144 | smart00144, PI3K_rbd, PI3-kinase family, Ras-binding domain; Certain members of the PI3K family possess Ras-binding domains in their N-termini | 175 | 4e-14 | 33% (33/99) | PI3K_rbd | | 5 | | |
| pfam10 | PF03251 | pfam03251, Tymo_45kd_70kd, Tymovirus 45/70Kd protein | 110 | 4e-05 | 21% (65/306) | Tymo_45kd_70kd | | 9 | | |
| Annotation Name | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, delta isoform related cluster |
| Score | 4960&emsp |
| E-value | 0.0 |
| % Sequence Identity | 90% (949/1044) |
| Locus | PK3CD |
| EC Number | 2.7.1.153 |
| COG Function | |
| KEGG Pathway | Apoptosis Inositol phosphate metabolism Jak-STAT signaling pathway Phosphatidylinositol signaling system Regulation of actin cytoskeleton Toll-like receptor signaling pathway |
| Source | Accession | Description | Score | E-value | % Sequence Identity | Locus | EC Number | Informative Hit | Function/Pathway | GeneOntology |
| uniref90 | UniRef90_O00329 | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, delta isoform related cluster | 4960 | 0.0 | 90% (949/1044) | PK3CD | 2.7.1.153 | 1 | | GO:0004428|inositol or phosphatidylinositol kinase activity|IEA; GO:0005942|phosphoinositide 3-kinase complex|IEA; GO:0005942|phosphoinositide 3-kinase complex|NAS; GO:0006468|protein amino acid phosphorylation|NAS; GO:0007165|signal transduction|IEA; GO:0007165|signal transduction|NAS; GO:0016301|kinase activity|IEA; GO:0016303|phosphatidylinositol 3-kinase activity|IEA; GO:0016303|phosphatidylinositol 3-kinase activity|NAS; GO:0016740|transferase activity|IEA; GO:0016773|phosphotransferase activity, alcohol group as acceptor|IEA; GO:0046934|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|IEA |
| nr | O00329 | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, delta isoform (PI3-kinase p110 subunit delta) (PtdIns-3-kinase p110) (PI3K) (p110delta) | 4960 | 0.0 | 90% (949/1044) | | | 3 | | |
| cog | SPAC458.05 | [TDBLU] COG5032 Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family | 574 | 2e-58 | 31% (157/504) | | | 1 | | |
| kegg | mmu:18707 | Pik3cd; phosphatidylinositol 3-kinase catalytic delta polypeptide [EC:2.7.1.153] [KO:K00922] | 4662 | 0.0 | 85% (892/1044) | Pik3cd | 2.7.1.153 | 2 | Apoptosis Inositol phosphate metabolism Jak-STAT signaling pathway Phosphatidylinositol signaling system Regulation of actin cytoskeleton Toll-like receptor signaling pathway | |
| smart | 00146 | smart00146, PI3Kc, Phosphoinositide 3-kinase, catalytic domain; Phosphoinositide 3-kinase isoforms participate in a variety of processes, including cell motility, the Ras pathway, vesicle trafficking and secretion, and apoptosis | 717 | 6e-77 | 39% (114/291) | PI3Kc | | 1 | | |
| smart2 | 00145 | smart00145, PI3Ka, Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases | 636 | 1e-67 | 51% (95/185) | PI3Ka | | 2 | | |
| smart3 | 00142 | smart00142, PI3K_C2, Phosphoinositide 3-kinase, region postulated to contain C2 domain; Outlier of C2 family | 233 | 8e-21 | 36% (35/97) | PI3K_C2 | | 3 | | |
| smart4 | 00143 | smart00143, PI3K_p85B, PI3-kinase family, p85-binding domain; Region of p110 PI3K that binds the p85 subunit | 219 | 3e-19 | 44% (35/78) | PI3K_p85B | | 4 | | |
| pfam | PF00454 | pfam00454, PI3_PI4_kinase, Phosphatidylinositol 3- and 4-kinase | 579 | 2e-59 | 38% (90/236) | PI3_PI4_kinase | | 1 | | |
| pfam2 | PF01500 | pfam01500, Keratin_B2, Keratin, high sulfur B2 protein | 107 | 9e-05 | 25% (51/200) | Keratin_B2 | | 10 | | |
| pfam3 | PF00613 | pfam00613, PI3Ka, Phosphoinositide 3-kinase family, accessory domain (PIK domain) | 538 | 1e-54 | 48% (88/182) | PI3Ka | | 2 | | |
| pfam4 | PF00794 | pfam00794, PI3K_rbd, PI3-kinase family, ras-binding domain | 311 | 2e-28 | 45% (49/108) | PI3K_rbd | | 3 | | |
| pfam5 | PF00792 | pfam00792, PI3K_C2, Phosphoinositide 3-kinase C2 | 290 | 6e-26 | 30% (43/141) | PI3K_C2 | | 4 | | |
| pfam6 | PF02192 | pfam02192, PI3K_p85B, PI3-kinase family, p85-binding domain | 219 | 1e-17 | 44% (35/78) | PI3K_p85B | | 5 | | |
| pfam7 | PF03154 | pfam03154, Atrophin-1, Atrophin-1 family | 150 | 1e-09 | 21% (143/659) | Atrophin-1 | | 6 | | |