LOCUS PFAMTCYTO 5966 bp DNA INV 20-FEB-1996 DEFINITION Plasmodium falciparum mitochondrial cytochrome b and cytochrome oxidase subunits 1 and 3 (Cyb, Cox1, and Cox3) genes, complete cds. ACCESSION M99416 NID g1197814 KEYWORDS cytochrome b; cytochrome oxidase; promoter. SOURCE Plasmodium falciparum (strain Malay Camp) DNA. ORGANISM Mitochondrion Plasmodium falciparum Eukaryotae; mitochondrial eukaryotes; Alveolata; Apicomplexa; Haemosporida; Plasmodium. REFERENCE 1 (bases 2315 to 2902) AUTHORS Suplick,K., Akella,R., Saul,A. and Vaidya,A.B. TITLE Molecular cloning and partial sequence of a 5.8 kilobase pair repetitive DNA from Plasmodium falciparum JOURNAL Mol. Biochem. Parasitol. 30 (3), 289-290 (1988) MEDLINE 89040026 REFERENCE 2 (sites) AUTHORS Suplick,K., Morrisey,J. and Vaidya,A.B. TITLE Complex transcription from the extrachromosomal DNA encoding mitochondrial functions of Plasmodium yoelii JOURNAL Mol. Cell. Biol. 10 (12), 6381-6388 (1990) MEDLINE 91061745 REFERENCE 3 (bases 1 to 5966) AUTHORS Vaidya,A.B., Lashgari,M.S., Pologe,L.G. and Morrisey,J. TITLE Structural features of Plasmodium cytochrome b that may underlie susceptibility to 8-aminoquinolines and hydroxynaphthoquinones JOURNAL Mol. Biochem. Parasitol. 58 (1), 33-42 (1993) MEDLINE 93211452 REFERENCE 4 (bases 1 to 5966) AUTHORS Vaidya,A.B. TITLE Direct Submission JOURNAL Submitted (14-NOV-1992) Akhil Vaidya, Microbiology and Immunology, Hahnemann University, Philadelphia, PA 19102-1192, USA REFERENCE 5 (bases 1 to 5966) AUTHORS Vaidya,A.B. TITLE Direct Submission JOURNAL Submitted (04-FEB-1996) Akhil Vaidya, Microbiology and Immunology, Hahnemann University, Philadelphia, PA 19102-1192, USA FEATURES Location/Qualifiers source 1..5966 /organism="Plasmodium falciparum" /mitochondrion /strain="Malay Camp" CDS complement(2000..2752) /gene="Cox3" /note="CDS inferred from primer extension experiments; open reading frame starts at position 2839; there is no ATG codon; putative" /citation=[2] /citation=[3] /codon_start=1 /function="mitochondrial electron transport" /product="cytochrome oxidase subunit 3" /db_xref="PID:g1197815" /transl_except=(pos:complement(2750..2752),aa:OTHER) /transl_table=4 /translation="XILFSNLSNIKAHLVSYPALTSLYGTSLKYFSVGILFTFNPIIL LIFVYSIRESFYSVFSSLTSGMLSIIISEALLFFTYFWGILHFSLSPYPLSNEGIIIT SSRMLILTITFILASASCMTACLQVFIEKGMSFEISSIICIIYLLGECFASLQTTEYL HLSYHINDTVYTTLFYCVTGLHFSHVVIGLLLLIIYFIRIIEIYDTSTEWFINSFGIS YIVIPHTDQITILYWHFVEIVWLFIEFLFYSE" gene complement(2000..2752) /gene="Cox3" misc_signal complement(2736..2747) /gene="Cox3" /note="12 nucleotide sequence present at the 5' ends of all mRNA coding regions of 6 kb DNA of Plasmodium species; putative" /citation=[2] /citation=[3] /function="promoter-like sequence" misc_signal 3302..3313 /gene="Cox1" /note="12 nucleotide sequence present at the 5' ends of all mRNA coding regions of the 6 kb mitochondrial DNA of Plasmodium species; putative" /citation=[2] /citation=[3] /function="promoter-like sequence" gene 3302..4737 /gene="Cox1" CDS 3304..4737 /gene="Cox1" /note="5' end inferred from primer extension of mRNA from homologous P. yoelii; open reading frame starts from 3218 but not present in mRNA; there is no initiation ATG codon; putative" /citation=[2] /citation=[3] /codon_start=1 /function="mitochondrial electron transport" /product="cytochrome oxidase subunit 1" /db_xref="PID:g1197816" /transl_except=(pos:3304..3306,aa:OTHER) /transl_table=4 /translation="XIVLNRYSLITNCNHKTLGLYYLWFSFLFGSYGFLLSVILRTEL YSSSLRIIAQENVNLYNMIFTIHGIIMIFFNIMPGLFGGFGNYFLPILCGSPELAYPR INSISLLLQPIAFVLVILSTAAEFGGGTGWTLYPPLSTSLMSLSPVAVDVIIFGLLVS GVASIMSSLNFITTVMHLRAKGLTLGILSVSTWSLIITSGMLLLTLPVLTGGVLMLLS DLHFNTLFFDPTFAGDPILYQHLFWFFGHPEVYILILPAFGVISHVISTNYCRNLFGN QSMILAMGCIAVLGSLVWVHHMYTTGLEVDTRAYFTSTTILISIPTGTKVFNWICTYM SSNFGMIHSSSLLSLLFICTFTFGGTTGVILGNAAIDVALHDTYYVIAHFHFVLSIGA IIGLFTTVSAFQDNFFGKNLRENSIVILWSMLFFVGVILTFLPMHFLGFNVMPRRIPD YPDALNGWNMICSIGSTMTLFGLLIFK" misc_signal 4744..4755 /gene="Cyb" /note="12 nucleotide sequence present at the 5' ends of all mRNA coding regions of the 6 kb mitochondrial DNA of Plasmodium species; putative" /citation=[2] /citation=[3] /function="promoter-like sequence" gene 4744..5888 /gene="Cyb" CDS 4758..5888 /gene="Cyb" /note="5' end established by primer extension analysis in P. yoelii; extrapolated here for P. falciparum; putative" /citation=[2] /citation=[3] /codon_start=1 /function="mitochondrial electron transport" /product="cytochrome b" /db_xref="PID:g1197817" /transl_table=4 /translation="MNFYSINLVKAHLINYPCPLNINFLWNYGFLLGIIFFIQIITGV FLASRYTPDVSYAYYSIQHILRELWSGWCFRYMHATGASLVFLLTYLHILRGLNYSYM YLPLSWISGLILFMIFIVTAFVGYVLPWGQMSYWGATVITNLLSSIPVAVIWICGGYT VSDPTIKRFFVLHFILPFIGLCIVFIHIFFLHLHGSTNPLGYDTALKIPFYPNLLSLD VKGFNNVIILFLIQSLFGIIPLSHPDNAIVVNTYVTPSQIVPEWYFLPFYAMLKTVPS KPAGLVIVLLSLQLLFLLAEQRSLTTIIQFKMIFGARDYSVPIIWFMCAFYALLWIGC QLPQDIFILYGRLFIVLFFCSGLFVLVHYRRTHYDYSSQANI" BASE COUNT 1933 a 936 c 949 g 2148 t ORIGIN 1 atgattggaa aatataacta tagttaccat agctgtagat ggatgcttcg atatatagta 61 tattacagta tcaatcggat ttacatgctc agccgccaaa aactataacg atattattac 121 cgtacaagcc gttagcaaga catgataggg agttggcaag ttaaagaagt tctggtttat 181 aatagatacg ttattaatgt taggatgtat gggatatttg tagtacacct tgattggttt 241 tactatttat acttatcgat aaatgttcgg tattgcatgc ctggtgtttt taatatagac 301 gctgacttcc tggctaaact tcccaatgat atatcttcca aatagatttc gcagaaaacc 361 gtctatattc atgtttgatt gacctttaac cactaattac gaatcttcca agaatatttt 421 aagagtccaa ggttcggtct attattttcc tgttctgtaa ttagatcaca tgttttatag 481 ttcatggaga catggctata accactattc atagagacaa ctaatggaat ctctctcgat 541 ttccagatgt tgagttacta agaggattct ctccacactt caattcgtac ttccactacc 601 agaatatact ctcctgttct aaaattctag gatttttcgc gttttttcag gagaaatccg 661 tatatcgatg tcttttaatc aatgctattg gattcaacgt ccaggacttc ctgacgctta 721 ataacgattt ctacttccag cagccatttt tggttcagct acaagttcac tgtcaactac 781 catgttacga cttcgcaccg actgtttctt ttacctcacg agtcgatcag gaaggtttca 841 tccttaaatc tcgtaaccat gccaacacat aagaactttt agggaagtta aggtgctcag 901 ggtcttaccg tcgggccgta tgattccaca tattcatgga taattctatt tattaggagt 961 ctcacactag cgacaatggg gaagtcgtta caccgttcat gcaggacgga gattacccga 1021 caaggaattt tgctacctta ggaccgttta aaatacagcc gccgtttatc attgatgccg 1081 ggcagatgtc agtaacttga aatattcatc agaattatca gtgacttgtg ttgtaacctt 1141 acagacgctt ccagtaattt aacttcttat aaatggaagc gcggtttccc gggtatccaa 1201 tccagtgctc cattcaaggc atagagactc agcctatgtt caactttgta gagttatatt 1261 ataataaagc ttttggtatc tcgtaatgta gaacaatatt gagttgaccg tcaaatcctt 1321 ttcattaaaa gagtggatta aatgcccagc caacaccatc caatttgatt gggaattatc 1381 tgtgttacaa atttttgatc ccaggctggt aaaaaatgta aacttttagc ccataagaat 1441 agaaacagat gccaggccaa taactcaaac agagctatga cgctatcaat ttttagcaag 1501 acggataaat ttttcataga acttaacgta tcatcatcca tgcaaagata aaacggtaga 1561 tagggaacaa actgcctcaa gacgttctta acccagctca cgcatcgctt ctaacggtga 1621 actctcattc caatggaacc ttgttcaagt tcaaatagat tggtaaggta tagtgtttac 1681 tatcaaatga aacaatgtgt tccaccgcta gtgtttgctt ctaacattcc acttgcttat 1741 aactgtatgg acgtaacctc caggcaaaga aaatgaccgg tcaaaacgga atcaattaac 1801 tatggatagc tgatactatc aatttatcat tactcaagtc agcatagtat atatgaaggt 1861 ttctatggaa acacacttcc cttctcgcca tttgatagcg gttaaccttt ccttttcctt 1921 acgtactcta gctatgaaca caattgtcta ttcgtacaat tattcatata tatatttgaa 1981 acaggacata catgttcatt tattctgaat agaataagaa ctctataaat aaccagacta 2041 tttcaacaaa atgccaatat aaaattgtaa tttgatcagt gtgaggtata acaatatatg 2101 atataccgaa agaatttata aaccattcgg tagaagtatc atatatttct attattctta 2161 taaagtatat tattaataat aataaaccta ttactacatg agaaaaatgt aatcctgtaa 2221 cacaataaaa taatgtagta tatacagtat catttatatg atatgataaa tgtaaatact 2281 ctgtagtttg tagagatgca aaacattctc ctaataagta tattatacaa ataatactag 2341 agatttcaaa actcattcct ttttctataa atacttgtaa acatgcagtc atacatgatg 2401 cactagctaa tataaatgta attgttaaga ttaacattct tgatgaagta atgataatac 2461 cttcattact taatggatat ggtgataaac taaaatgtaa tataccccaa aaatatgtaa 2521 agaataataa agcttctgat attatgatag ataacatacc agaagttaaa gatgaaaata 2581 cagaataaaa actttctcga atagaatata caaatattaa taggattata gggttaaatg 2641 taaataatat ccctacagaa aagtatttta aagatgtacc atataatgat gttaatgcag 2701 gatatgaaac tagatgtgct tttatatttg ataaattact aaataaaata aatttataag 2761 aacggtgaga taatgtgccg taaacatata acggtaagaa ggttcgccgg ggataacagg 2821 ttatagtata tatagagctc taatctttat atactattgg cacctccatg tcgtctcatc 2881 gcagccttgc aataaataat atctagcgtg tattgttgcc ttgtacacac cgctcgtcac 2941 gcaatatcaa tatactgggt atagaactcc aggcgttaac ctgtagagtt gagatggaaa 3001 cagccggaaa ggtaatttta cgcccttaac gtaaagatca tttatgaaat agattagcat 3061 gggactaaaa aatgttatgt tgttggttta agccctatta ccatacaaga gatcgcgtac 3121 tttggaccga ataaagctgt gaggaaacta cattaaagga actcgactgg cctacactat 3181 aagaacgaac gcttttaacg cctgacatgg atggataata ctcgactctt ccaaagtata 3241 accgctgtcg ctgggactgt atggatcaaa tatttctcat ttatatccga gcctcatgtt 3301 atttttattg ttttaaatag atattcactt attacaaatt gtaaccataa aactttagga 3361 ttatactatt tatggttttc atttttattt ggtagttatg gatttttatt atcagtaata 3421 ctacgtactg aattatattc ttcatcttta agaataattg cacaagaaaa tgtaaatcta 3481 tataatatga tatttacaat tcacggaata attatgattt ttttcaatat aatgccagga 3541 ttattcggag gatttggtaa ttactttcta cctattttat gtggatctcc agaattagca 3601 tatcctagaa ttaatagtat atctttactg ttacaaccaa ttgcttttgt tttagttata 3661 ttatctactg cagcagaatt tggtggtgga actggatgga ctttatatcc accattaagt 3721 acatctttaa tgtcattatc tcctgtagct gtagatgtaa taatttttgg tttattagta 3781 tctggagtcg ctagtattat gtcttcatta aattttatta ctacagtaat gcatttaaga 3841 gcaaaaggat taacacttgg tatattaagt gtttctacat ggtcattgat cattacatca 3901 ggaatgttat tgctaacact accggtttta actggaggag tattaatgtt attatcagac 3961 ttacatttta atactttatt ttttgaccca acatttgcag gagatccaat attatatcaa 4021 catttattct ggttttttgg acatcctgaa gtatacattt taatattacc tgcttttgga 4081 gtaattagtc atgtaatttc tactaattat tgcagaaatc tatttggtaa tcaatctatg 4141 atacttgcta tgggatgtat agctgtttta ggaagcttag tatgggtaca tcatatgtac 4201 actactggtt tagaagttga tactagagct tattttactt cgactaccat tttaatatca 4261 atacctaccg gtacaaaagt atttaactgg atatgtacat atatgagtag taattttggt 4321 atgatacaca gctcttcatt attgtcatta ttatttatat gtacatttac atttggaggt 4381 actactggag ttatattagg taatgctgcc attgatgtag cattacatga cacatattat 4441 gttattgctc atttccattt tgtactatca attggtgcaa ttattggatt atttacaact 4501 gtaagtgcat ttcaagataa tttctttggt aaaaacttac gtgaaaattc tattgtaata 4561 ctatggtcaa tgttattttt tgtaggtgta atattaacat ttttacctat gcatttttta 4621 ggatttaatg taatgcctag acgtattcct gattatccag acgctttaaa tggatggaat 4681 atgatttgtt ctattgggtc aacaatgact ttatttggtt tactaatttt taaataatat 4741 tactatttat tgtttttatg aacttttact ctattaattt agttaaagca cacttaataa 4801 attacccatg tccattgaac ataaactttt tatggaatta cggattcctt ttaggaataa 4861 tattttttat tcaaattata acaggtgtat ttttagcaag tcgatataca ccagatgttt 4921 catatgcata ttatagtata caacacattt taagagaatt atggagtgga tggtgtttta 4981 gatacatgca cgcaacaggt gcttctcttg tatttttatt aacatatctt catattttaa 5041 gaggattaaa ttactcatat atgtatttac cattatcatg gatatctgga ttgattttat 5101 ttatgatatt tattgtaact gctttcgttg gttatgtctt accatggggt caaatgagtt 5161 attggggtgc aactgtaatt actaacttgt tatcctctat tccagtagca gtaatttgga 5221 tatgtggagg atatactgtg agtgatccta caataaaacg attttttgta ctacatttta 5281 tcttaccatt tattggatta tgtattgtat ttatacatat atttttctta catttacatg 5341 gtagcacaaa tcctttaggg tatgatacag cattaaaaat acccttttat ccaaatctat 5401 taagtcttga tgttaaagga tttaataatg ttataatttt atttctaata caaagtttat 5461 ttggaattat acctttatca catcctgata atgctatcgt agtaaataca tatgttactc 5521 catctcaaat tgtacctgaa tggtactttc taccatttta tgcaatgtta aaaactgttc 5581 caagtaaacc agctggttta gtaattgtat tattatcatt acaattatta ttcttattag 5641 cagaacaaag aagtttaaca actataattc aatttaaaat gatttttggt gctagagatt 5701 attctgttcc tattatatgg tttatgtgtg cattctatgc tttattatgg attggatgtc 5761 aattaccaca agatatattc attttatatg gtcgattatt tattgtatta tttttctgta 5821 gtggtttatt tgtacttgtt cattatagac gaacacatta tgattacagc tcccaagcaa 5881 acatataata ttacaagatt gtgataagat gacatttctg agtattgagc ggaacaaatc 5941 agaccgtaag gttataatta tgtact //