LOCUS MMU489607 16301 bp DNA circular ROD 06-MAR-2004 DEFINITION Mus musculus complete mitochondrial genome, clone L929. ACCESSION AJ489607 VERSION AJ489607.1 GI:34555991 KEYWORDS 12S ribosomal RNA; 12S rRNA gene; 16S ribosomal RNA; 16S rRNA gene; ATP synthase subunit 6; ATP Synthase subunit 8; ATPase 6 gene; ATPase 8 gene; COI gene; COII gene; COIII gene; Cytb gene; cytochrome b; cytochrome c oxidase polypeptide 1; cytochrome c oxidase polypeptide 2; cytochrome c oxidase polypeptide 3; NADH dehydrogenase subunit 1; NADH dehydrogenase subunit 2; NADH dehydrogenase subunit 3; NADH dehydrogenase subunit 4; NADH dehydrogenase subunit 4L; NADH dehydrogenase subunit 5; NADH dehydrogenase subunit 6; ND1 gene; ND2 gene; ND3 gene; ND4 gene; ND4L gene; ND5 gene; ND6 gene; transfer RNA-Ala; transfer RNA-Arg; transfer RNA-Asn; transfer RNA-Asp; transfer RNA-Cys; transfer RNA-Gln; transfer RNA-Glu; transfer RNA-Gly; transfer RNA-His; transfer RNA-Ile; transfer RNA-Leu (CUN); transfer RNA-Leu (UUR); transfer RNA-Lys; transfer RNA-Met; transfer RNA-Phe; transfer RNA-Pro; transfer RNA-Ser (AGY); transfer RNA-Ser (UCN); transfer RNA-Thr; transfer RNA-Trp; transfer RNA-Tyr; transfer RNA-Val; tRNA-Ala gene; tRNA-Arg gene; tRNA-Asn gene; tRNA-Asp gene; tRNA-Cys gene; tRNA-Gln gene; tRNA-Glu gene; tRNA-Gly gene; tRNA-His gene; tRNA-Ile gene; tRNA-Leu (CUN) gene; tRNA-Leu (UUR) gene; tRNA-Lys gene; tRNA-Met gene; tRNA-Phe gene; tRNA-Pro gene; tRNA-Ser (AGY) gene; tRNA-Ser (UCN) gene; tRNA-Thr gene; tRNA-Trp gene; tRNA-Tyr gene; tRNA-Val gene. SOURCE mitochondrion Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 AUTHORS Acin-Perez,R., Bayona-Bafaluy,M.P., Bueno,M., Machicado,C., Fernandez-Silva,P., Perez-Martos,A., Montoya,J., Lopez-Perez,M.J., Sancho,J. and Enriquez,J.A. TITLE An intragenic suppressor in the cytochrome c oxidase I gene of mouse mitochondrial DNA JOURNAL Hum. Mol. Genet. 12 (3), 329-339 (2003) MEDLINE 22442040 REFERENCE 2 AUTHORS Bayona-Bafaluy,M.P., Acin-Perez,R., Mullikin,J.C., Park,J.S., Moreno-Loshuertos,R., Hu,P., Perez-Martos,A., Fernandez-Silva,P., Bai,Y. and Enriquez,J.A. TITLE Revisiting the mouse mitochondrial DNA sequence JOURNAL Nucleic Acids Res. 31 (18), 5349-5355 (2003) MEDLINE 22836051 REFERENCE 3 (bases 1 to 16301) AUTHORS Enriquez,J.A. TITLE Direct Submission JOURNAL Submitted (11-JUN-2002) Enriquez J.A., Bioquimica y Biologia Mol. y Cel., Universidad de Zaragoza, Miguel Servet 177, Zaragoza /50013, SPAIN FEATURES Location/Qualifiers source 1..16301 /organism="Mus musculus" /organelle="mitochondrion" /mol_type="genomic DNA" /strain="C3H/An" /db_xref="taxon:10090" /clone="L929" /sex="male" /cell_line="L" /cell_type="fibroblast" /tissue_type="connective" gene 1..68 /gene="tRNA-Phe" tRNA 1..68 /gene="tRNA-Phe" /product="tRNA-Phe" /note="codon recognized: UUC" /anticodon=(pos:33..35,aa:Phe) gene 70..1024 /gene="12S rRNA" rRNA 70..1024 /gene="12S rRNA" /product="12S ribosomal RNA" gene 1025..1093 /gene="tRNA-Val" tRNA 1025..1093 /gene="tRNA-Val" /product="tRNA-Val" /note="codon recognized: GUA" /anticodon=(pos:1057..1059,aa:Val) gene 1094..2675 /gene="16S rRNA" rRNA 1094..2675 /gene="16S rRNA" /product="16S ribosomal RNA" gene 2676..2750 /gene="tRNA-Leu (UUR)" tRNA 2676..2750 /gene="tRNA-Leu (UUR)" /product="tRNA-Leu" /note="codon recognized: UUA" /anticodon=(pos:2711..2713,aa:Leu) gene 2751..3707 /gene="ND1" CDS 2751..3707 /gene="ND1" /EC_number="1.6.5.3" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 1" /protein_id="CAD33907.1" /db_xref="GI:34555992" /translation="MFFINILTLLVPILIAMAFLTLVERKILGYMQLRKGPNIVGPYG ILQPFADAMKLFMKEPMRPLTTSMSLFIIAPTLSLTLALSLWVPLPMPHPLINLNLGI LFILATSSLSVYSILWSGWASNSKYSLFGALRAVAQTISYEVTMAIILLSVLLMNGSY SLQTLITTQEHMWLLLPAWPMAMMWFISTLAETNRAPFDLTEGESELVSGFNVEYAAG PFALFFMAEYTNIILMNALTTIIFLGPLYYINLPELYSTNFMMEALLLSSTFLWIRAS YPRFRYDQLMHLLWKNFLPLTLALCMWHISLPIFTAGVPPYM" gene 3706..3774 /gene="tRNA-Ile" tRNA 3706..3774 /gene="tRNA-Ile" /product="tRNA-Ile" /note="codon recognized: AUC" /anticodon=(pos:3735..3737,aa:Ile) gene complement(3772..3842) /gene="tRNA-Gln" tRNA complement(3772..3842) /gene="tRNA-Gln" /product="tRNA-Gln" /note="codon recognized: CAA" /anticodon=(pos:3808..3810,aa:Gln) gene 3845..3913 /gene="tRNA-Met" tRNA 3845..3913 /gene="tRNA-Met" /product="tRNA-Met" /note="codon recognized: AUG" /anticodon=(pos:3875..3877,aa:Met) gene 3914..4951 /gene="ND2" CDS 3914..4951 /gene="ND2" /EC_number="1.6.5.3" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 2" /protein_id="CAD33908.1" /db_xref="GI:34555993" /translation="MNPITLAIIYFTIFLGPVITMSSTNLMLMWVGLEFSLLAIIPML INKKNPRSTEAATKYFVTQATASMIILLAIVLNYKQLGTWMFQQQTNGLILNMTLMAL SMKLGLAPFHFWLPEVTQGIPLHMGLILLTWQKIAPLSILIQIYPLLNSTIILMLAIT SIFMGAWGGLNQTQMRKIMAYSSIAHMGWMLAILPYNPSLTLLNLMIYIILTAPMFMA LMLNNSMTINSISLLWNKTPAMLTMISLMLLSLGGLPPLTGFLPKWIIITELMKNNCL IMATLMAMMALLNLFFYTRLIYSTSLTMFPTNNNSKMMTHQTKTKPNLMFSTLAIMST MTLPLAPQLIT" gene 4950..5016 /gene="tRNA-Trp" tRNA 4950..5016 /gene="tRNA-Trp" /product="tRNA-Trp" /note="codon recognized: UGA" /anticodon=(pos:4981..4983,aa:Trp) gene complement(5018..5086) /gene="tRNA-Ala" tRNA complement(5018..5086) /gene="tRNA-Ala" /product="tRNA-Ala" /note="codon recognized: GCA" /anticodon=(pos:5054..5056,aa:Ala) gene complement(5089..5159) /gene="tRNA-Asn" tRNA complement(5089..5159) /gene="tRNA-Asn" /product="tRNA-Asn" /note="codon recognized: AAC" /anticodon=(pos:5126..5128,aa:Asn) rep_origin 5160..5191 /note="L-strand origin of replication" /direction=RIGHT gene complement(5192..5257) /gene="tRNA-Cys" tRNA complement(5192..5257) /gene="tRNA-Cys" /product="tRNA-Cys" /note="codon recognized: UGC" /anticodon=(pos:5227..5229,aa:Cys) gene complement(5260..5326) /gene="tRNA-Tyr" tRNA complement(5260..5326) /gene="tRNA-Tyr" /product="tRNA-Tyr" /note="codon recognized: UAC" /anticodon=(pos:5296..5298,aa:Tyr) gene 5328..6872 /gene="COI" CDS 5328..6872 /gene="COI" /EC_number="1.9.3.1" /function="oxidative phosporylation" /codon_start=1 /transl_table=2 /product="cytochrome c oxidase polypeptide 1" /protein_id="CAD33909.1" /db_xref="GI:34555994" /translation="MFINRWLFSTNHKDIGTLYLLFGAWAGMVGTALSILIRAELGQP GALLGDDQIYNVIVTAHAFVMIFFMVMPMMIGGFGNWLVPLMIGAPDMAFPRMNNMSF WLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILG AINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTT FFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGIISHVVTYYSGKKEPFGYMGMVWA MMSIGFLGFIVWAHHMFTVGLDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKW SPAMLWALGFIFLFTVGGLTGIVLSNSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMAG FVHWFPLFSGFTLDDTWAKAHFAIMFVGANMTFFPQHFLGLSGMPRRYSDYPDAYTTW NTVSSMGSFISLTAVLIMIFMIWEAFASKREVMSVSYASTNLEWLHGCPPPYHTFEEP TYVKVK" variation 6063 /gene="COI" /product="COI with Leu246Ile & Val421Ala" /note="COI C6063A missense mutation in heteroplasmic form" /citation=[1] /evidence=experimental /frequency=".82" /phenotype="suppressor of T6589C missense mutation" /replace="a" variation 6589 /gene="COI" /product="COI with VAl421Ala" /note="COI-T6589C missense is in homoplasmic form in the L929 cell line" /citation=[1] /evidence=experimental /phenotype="mild impairment of COX activity" /replace="c" gene complement(6870..6938) /gene="tRNA-Ser (UCN)" tRNA complement(6870..6938) /gene="tRNA-Ser (UCN)" /product="tRNA-Ser" /note="codon recognized: UCA; tRNAscan:Ser (TGA) 39..37" /anticodon=(pos:6906..6908,aa:Ser) gene 6942..7011 /gene="tRNA-Asp" tRNA 6942..7011 /gene="tRNA-Asp" /product="tRNA-Asp" /note="codon recognized: GAC" /anticodon=(pos:6973..6975,aa:Asp) gene 7013..7696 /gene="COII" CDS 7013..7696 /gene="COII" /EC_number="1.9.3.1" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="cytochrome c oxidase polypeptide 2" /protein_id="CAD33910.1" /db_xref="GI:34555995" /translation="MAYPFQLGLQDATSPIMEELMNFHDHTLMIVFLISSLVLYIISL MLTTKLTHTSTMDAQEVETIWTILPAVILIMIALPSLRILYMMDEINNPVLTVKTMGH QWYWSYEYTDYEDLCFDSYMIPTNDLKPGELRLLEVDNRVVLPMELPIRMLISSEDVL HSWAVPSLGLKTDAIPGRLNQATVTSNRPGLFYGQCSEICGSNHSFMPIVLEMVPLKY FENWSASMI" gene 7700..7764 /gene="tRNA-Lys" tRNA 7700..7764 /gene="tRNA-Lys" /product="tRNA-Lys" /note="codon recognized: AAA" /anticodon=(pos:7726..7728,aa:Lys) gene 7766..7969 /gene="ATPase 8" CDS 7766..7969 /gene="ATPase 8" /EC_number="3.6.1.3" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="ATP Synthase subunit 8" /protein_id="CAD33911.1" /db_xref="GI:34555996" /translation="MPQLDTSTWFITIISSMITLFILFQLKVSSQTFPLAPSPKSLTT MKVKTPWELKWTKIYLPHSLPQQ" gene 7927..8607 /gene="ATPase 6" CDS 7927..8607 /gene="ATPase 6" /EC_number="3.6.1.3" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="ATP synthase subunit 6" /protein_id="CAD33912.1" /db_xref="GI:34555997" /translation="MNENLFASFITPTMMGFPIVVAIIMFPSILFPSSKRLINNRLHS FQHWLVKLIIKQMMLIHTPKGRTWTLMIVSLIMFIGSTNLLGLLPHTFTPTTQLSMNL SMAIPLWAGAVITGFRHKLKSSLAHFLPQGTPISLIPMLIIIETISLFIQPMALAVRL TANITAGHLLMHLIGGATLVLMNISPPTATITFIILLLLTILEFAVALIQAYVFTLLV SLYLHDNT" gene 8607..9390 /gene="COIII" CDS 8607..9390 /gene="COIII" /EC_number="1.9.3.1" /function="oxidative phosphorylation" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:9390,aa:TERM) /transl_table=2 /product="cytochrome c oxidase polypeptide 3" /protein_id="CAD33913.1" /db_xref="GI:34555998" /translation="MTHQTHAYHMVNPSPWPLTGAFSALLLTSGLVMWFHYNSITLLT LGLLTNILTMYQWWRDVIREGTYQGHHTPIVQKGLRYGMILFIVSEVFFFAGFFWAFY HSSLVPTHDLGGCWPPTGISPLNPLEVPLLNTSVLLASGVSITWAHHSLMEGKRNHMN QALLITIMLGLYFTILQASEYFETSFSISDGIYGSTFFMATGFHGLHVIIGSTFLIVC LLRQLKFHFTSKHHFGFEAAAWYWHFVDVIWLFLYVSIYWWGS" gene 9391..9458 /gene="tRNA-Gly" tRNA 9391..9458 /gene="tRNA-Gly" /product="tRNA-Gly" /note="codon recognized: GGA" /anticodon=(pos:9421..9423,aa:Gly) gene 9459..9806 /gene="ND3" CDS 9459..9806 /gene="ND3" /EC_number="1.6.5.3" /function="oxidative phosphoryolation" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 3" /protein_id="CAD33914.1" /db_xref="GI:34555999" /translation="MNLYTVIFINILLSLTLILVAFWLPQMNLYSEKANPYECGFDPT SSARLPFSMKFFLVAITFLLFDLEIALLLPLPWAIQTIKTSTMMIMAFILVTILSLGL AYEWTQKGLEWTE" gene 9808..9877 /gene="tRNA-Arg" tRNA 9808..9877 /gene="tRNA-Arg" /product="tRNA-Arg" /note="codon recognized: CGA" /anticodon=(pos:9840..9842,aa:Arg) misc_feature 9821..9830 /gene="tRNA-Arg" /note="highly polymorphic region" gene 9879..10175 /gene="ND4L" CDS 9879..10175 /gene="ND4L" /EC_number="1.6.5.3" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 4L" /protein_id="CAD33915.1" /db_xref="GI:34556000" /translation="MPSTFFNLTMAFSLSLLGTLMFRSHLMSTLLCLEGMVLSLFIMT SVTSLNSNSMSSMPIPITILVFAACEAAVGLALLVKVSNTYGTDYVQNLNLLQC" gene 10169..11546 /gene="ND4" CDS 10169..11546 /gene="ND4" /EC_number="1.6.5.3" /function="oxidative phosphorylation" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:11546,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 4" /protein_id="CAD33916.1" /db_xref="GI:34556001" /translation="MLKIILPSLMLLPLTWLSSPKKTWTNVTSYSFLISLTSLTLLWQ TDENYKNFSNMFSSDPLSTPLIILTAWLLPLMLMASQNHLKKDNNVLQKLYISMLISL QILLIMTFSATELIMFYILFEATLIPTLIIITRWGNQTERLNAGIYFLFYTLIGSIPL LIALILIQNHVGTLNLMILSFTTHTLDASWSNNLLWLACMMAFLIKMPLYGVHLWLPK AHVEAPIAGSMILAAILLKLGSYGMIRISIILDPLTKYMAYPFILLSLWGMIMTSSIC LRQTDLKSLIAYSSVSHMALVIASIMIQTPWSFMGATMLMIAHGLTSSLLFCLANSNY ERIHSRTMIMARGLQMVFPLMATWWLMASLANLALPPSINLMGELFITMSLFSWSNFT IILMGINIIITGMYSMYMIITTQRGKLTNHMINLQPSHTRELTLMALHMIPLILLTTS PKLITGLTM" gene 11547..11614 /gene="tRNA-His" tRNA 11547..11614 /gene="tRNA-His" /product="tRNA-His" /note="codon recognized: CAC" /anticodon=(pos:11577..11579,aa:His) gene 11615..11673 /gene="tRNA-Ser (AGY)" tRNA 11615..11673 /gene="tRNA-Ser (AGY)" /product="tRNA-Ser" /note="codon recognized: AGC" /anticodon=(pos:11634..11636,aa:Ser) gene 11673..11743 /gene="tRNA-Leu (CUN)" tRNA 11673..11743 /gene="tRNA-Leu (CUN)" /product="tRNA-Leu" /note="codon recognized: CUA" /anticodon=(pos:11705..11707,aa:Leu) gene 11744..13567 /gene="ND5" CDS 11744..13567 /gene="ND5" /EC_number="1.6.5.3" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 5" /protein_id="CAD33917.1" /db_xref="GI:34556002" /translation="MNIFTTSILLIFILLLSPILISMSNLIKHINFPLYTTTSIKFSF IISLLPLLMFFHNNMEYMITTWHWVTMNSMELKMSFKTDFFSILFTSVALFVTWSIMQ FSSWYMHSDPNINRFIKYLTLFLITMLILTSANNMFQLFIGWEGVGIMSFLLIGWWYG RTDANTAALQAILYNRIGDIGFILAMVWFSLNMNSWELQQIMFSNNNDNLIPLMGLLI AATGKSAQFGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLVRFHPLTTNNNFILTT MLCLGALTTLFTAICALTQNDIKKIIAFSTSSQLGLMMVTLGMNQPHLAFLHICTHAF FKAMLFMCSGSIIHSLADEQDIRKMGNITKIMPFTSSCLVIGSLALTGMPFLTGFYSK DLIIEAINTCNTNAWALLITLIATSMTAMYSMRIIYFVTMTKPRFPPLISINENDPDL MNPIKRLAFGSIFAGFVISYNIPPTSIPVLTMPWFLKTTALIISVLGFLIALELNNLT MKLSMNKANPYSSFSTLLGFFPSIIHRITPMKSLNLSLKTSLTLLDLIWLEKTIPKST STLHTNMTTLTTNQKGLIKLYFMSFLINIILIIILYSINLE" gene complement(13554..14072) /gene="ND6" CDS complement(13554..14072) /gene="ND6" /EC_number="1.6.5.3" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 6" /protein_id="CAD33918.1" /db_xref="GI:34556003" /translation="MNNYIFVLSSLFLVGCLGLALKPSPIYGGLGLIVSGFVGCLMVL GFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPETWGSNWLILGFLVLGVIMEVFL ICVLNYYDEVGVINLDGLGDWLMYEVDDVGVMLEGGIGVAAMYSCATWMMVVAGWSLF AGIFIIIEITRD" gene 13887..13892 /gene="NADH dehydrogenase subunit 6" variation 13887..13892 /gene="NADH dehydrogenase subunit 6" /product="truncated ND6" /evidence=experimental /frequency=".52" /phenotype="impairs assembly of NADH dehydrogenase (Complex I)" /replace="ccccccc" gene complement(14073..14141) /gene="tRNA-Glu" tRNA complement(14073..14141) /gene="tRNA-Glu" /product="tRNA-Glu" /note="codon recognized: GAA" /anticodon=(pos:14109..14111,aa:Glu) gene 14147..15290 /gene="Cytb" CDS 14147..15290 /gene="Cytb" /EC_number="1.10.2.2" /function="oxidative phosphorylation" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:15290,aa:TERM) /transl_table=2 /product="cytochrome b" /protein_id="CAD33919.1" /db_xref="GI:34556004" /translation="MTNMRKTHPLFKIINHSFIDLPAPSNISSWWNFGSLLGVCLMVQ IITGLFLAMHYTSDTMTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGL YYGSYTFMETWNIGVLLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTL VEWIWGGFSVDKATLTRFFAFHFILPFIIAALAIVHLLFLHETGSNNPTGLNSDADKI PFHPYYTIKDILGILIMFLILMTLVLFFPDMLGDPDNYMPANPLNTPPHIKPEWYFLF AYAILRSIPNKLGGVLALILSILILALMPFLHTSKQRSLMFRPITQILYWILVANLLI LTWIGGQPVEHPFIIIGQLASISYFSIILILMPISGIIEDKMLKLYP" gene 15291..15357 /gene="tRNA-Thr" tRNA 15291..15357 /gene="tRNA-Thr" /product="tRNA-Thr" /note="codon recognized: ACA" /anticodon=(pos:15321..15323,aa:Thr) gene complement(15358..15424) /gene="tRNA-Pro" tRNA complement(15358..15424) /gene="tRNA-Pro" /product="tRNA-Pro" /note="codon recognized: CCA" /anticodon=(pos:15392..15394,aa:Pro) D-loop 15425..16301 ORIGIN 1 gttaatgtag cttaataaca aagcaaagca ctgaaaatgc ttagatggat aattgtatcc 61 cataaacaca aaggtttggt cctggcctta taattaatta gaggtaaaat tacacatgca 121 aacctccata gaccggtgta aaatccctta aacatttact taaaatttaa ggagagggta 181 tcaagcacat taaaatagct taagacacct tgcctagcca cacccccacg ggactcagca 241 gtgataaata ttaagcaata aacgaaagtt tgactaagtt atacctctta gggttggtaa 301 atttcgtgcc agccaccgcg gtcatacgat taacccaaac taattatctt cggcgtaaaa 361 cgtgtcaact ataaataaat aaatagaatt aaaatccaac ttatatgtga aaattcattg 421 ttaggaccta aactcaataa cgaaagtaat tctagtcatt tataatacac gacagctaag 481 acccaaactg ggattagata ccccactatg cttagccata aacctaaata attaaattta 541 acaaaactat ttgccagaga actactagcc atagcttaaa actcaaagga cttggcggta 601 ctttatatcc atctagagga gcctgttcta taatcgataa accccgctct acctcaccat 661 ctcttgctaa ttcagcctat ataccgccat cttcagcaaa ccctaaaaag gtattaaagt 721 aagcaaaaga atcaaacata aaaacgttag gtcaaggtgt agccaatgaa atgggaagaa 781 atgggctaca ttttcttata aaagaacatt actataccct ttatgaaact aaaggactaa 841 ggaggattta gtagtaaatt aagaatagag agcttaattg aattgagcaa tgaagtacgc 901 acacaccgcc cgtcaccctc ctcaaattaa attaaactta acataattaa tttctagaca 961 tccgtttatg agaggagata agtcgtaaca aggtaagcat actggaaagt gtgcttggaa 1021 taatcatagt gtagcttaat attaaagcat ctggcctaca cccagaagat ttcatgacca 1081 atgaacactc tgaactaatc ctagccctag ccctacacaa atataattat actattatat 1141 aaatcaaaac atttatccta ctaaaagtat tggagaaaga aattcgtaca tctaggagct 1201 atagaactag taccgcaagg gaaagatgaa agactaatta aaagtaagaa caagcaaaga 1261 ttaaaccttg taccttttgc ataatgaact aactagaaaa cttctaacta aaagaattac 1321 agctagaaac cccgaaacca aacgagctac ctaaaaacaa ttttatgaat caactcgtct 1381 atgtggcaaa atagtgagaa gatttttagg tagaggtgaa aagcctaacg agcttggtga 1441 tagctggtta cccaaaaaat gaatttaagt tcaattttaa acttgctaaa aaaacaacaa 1501 aatcaaaaag taagtttaga ttatagccaa aagagggaca gctcttctgg aacggaaaaa 1561 acctttaata gtgaataatt aacaaaacag cttttaacca ttgtaggcct aaaagcagcc 1621 accaataaag aaagcgttca agctcaacat aaaatttcaa ttaattccat aatttacacc 1681 aacttcctaa acttaaaatt gggttaatct ataactttat agatgcaaca ctgttagtat 1741 gagtaacaag aattccaatt ctccaggcat acgcgtataa caactcggat aaccattgtt 1801 agttaatcag actataggca ataatcacac tataaataat ccacctataa cttctctgtt 1861 aacccaacac cggaatgcct aaaggaaaga tccaaaaaga taaaaggaac tcggcaaaca 1921 agaaccccgc ctgtttacca aaaacatcac ctctagcatt acaagtatta gaggcactgc 1981 ctgcccagtg actaaagttt aacggccgcg gtatcctgac cgtgcaaagg tagcataatc 2041 acttgttcct taattaggga ctagcatgaa cggctaaacg agggtccaac tgtctcttat 2101 ctttaatcag tgaaattgac ctttcagtga agaggctgaa atataataat aagacgagaa 2161 gaccctatgg agcttaaatt atataactta tctatttaat ttattaaacc taatggccca 2221 aaaactatag tataagtttg aaatttcggt tggggtgacc tcggagaata aaaaatcctc 2281 cgaatgatta taacctagac ttacaagtca aagtaaaatc aacatatctt attgacccag 2341 atatattttg atcaacggac caagttaccc tagggataac agcgcaatcc tatttaagag 2401 ttcatatcga caattagggt ttacgacctc gatgttggat caggacatcc caatggtgta 2461 gaagctatta atggttcgtt tgttcaacga ttaaagtcct acgtgatctg agttcagacc 2521 ggagcaatcc aggtcggttt ctatctattt acgatttctc ccagtacgaa aggacaagag 2581 aaatagagcc accttacaaa taagcgctct caacttaatt tatgaataaa atctaaataa 2641 aatatatacg tacaccctct aacctagaga aggttattag ggtggcagag ccaggaaatt 2701 gcgtaagact taaaaccttg ttcccagagg ttcaaatcct ctccctaata gtgttcttta 2761 ttaatatcct aacactcctc gtccccattc taatcgccat agccttccta acattagtag 2821 aacgcaaaat cttagggtac atacaactac gaaaaggccc taacattgtt ggtccatacg 2881 gcattttaca accatttgca gacgccataa aattatttat aaaagaacca atacgccctt 2941 taacaacctc tatatcctta tttattattg cacctaccct atcactcaca ctagcattaa 3001 gtctatgagt tcccctacca ataccacacc cattaattaa tttaaaccta gggattttat 3061 ttattttagc aacatctagc ctatcagttt actccattct atgatcagga tgagcctcaa 3121 actccaaata ctcactattc ggagctttac gagccgtagc ccaaacaatt tcatatgaag 3181 taaccatagc tattatcctt ttatcagttc tattaataaa tggatcctac tctctacaaa 3241 cacttattac aacccaagaa cacatatgat tacttctgcc agcctgaccc atagccataa 3301 tatgatttat ctcaacccta gcagaaacaa accgggcccc cttcgacctg acagaaggag 3361 aatcagaatt agtatcaggg tttaacgtag aatacgcagc cggcccattc gcgttattct 3421 ttatagcaga gtacactaac attattctaa taaacgccct aacaactatt atcttcctag 3481 gacccctata ctatatcaat ttaccagaac tctactcaac taacttcata atagaagctc 3541 tactactatc atcaacattc ctatggatcc gagcatctta tccacgcttc cgttacgatc 3601 aacttataca tcttctatga aaaaactttc tacccctaac actagcatta tgtatgtgac 3661 atatttcttt accaattttt acagcgggag taccaccata catatagaaa tatgtctgat 3721 aaaagaatta ctttgataga gtaaattata gaggttcaag ccctcttatt tctaggacaa 3781 taggaattga acctacactt aagaattcaa aattctccgt gctacctaaa caccttatcc 3841 taatagtaag gtcagctaat taagctatcg ggcccatacc ccgaaaacgt tggtttaaat 3901 ccttcccgta ctaataaatc ctatcaccct tgccatcatc tacttcacaa tcttcttagg 3961 tcctgtaatc acaatatcca gcaccaacct aatactaata tgagtaggcc tggaattcag 4021 cctactagca attatcccca tactaatcaa caaaaaaaac ccacgatcaa ctgaagcagc 4081 aacaaaatac ttcgtcacac aagcaacagc ctcaataatt atcctcctgg ccatcgtact 4141 caactataaa caactaggaa catgaatatt tcaacaacaa acaaacggtc ttatccttaa 4201 cataacatta atagccctat ccataaaact aggcctcgcc ccattccact tctgattacc 4261 agaagtaact caagggatcc cactgcacat aggacttatt cttcttacat gacaaaaaat 4321 tgctccccta tcaattttaa ttcaaattta cccgctactc aactctacta tcattttaat 4381 actagcaatt acttctattt tcataggggc atgaggagga cttaaccaaa cacaaatacg 4441 aaaaattata gcctattcat caattgccca cataggatga atattagcaa ttcttcctta 4501 caacccatcc ctcactctac tcaacctcat aatctatatt attcttacag cccctatatt 4561 catagcactt atactaaata actctataac catcaactca atctcacttc tatgaaataa 4621 aactccagca atactaacta taatctcact gatattacta tccctaggag gccttccacc 4681 actaacagga ttcttaccaa aatgaattat catcacagaa cttataaaaa acaactgtct 4741 aattatagca acactcatag caataatagc tctactaaac ctattctttt atactcgcct 4801 aatttattcc acttcactaa caatatttcc aaccaacaat aactcaaaaa taataactca 4861 ccaaacaaaa actaaaccca acctaatatt ttccacccta gctatcataa gcacaataac 4921 cctaccccta gccccccaac taattaccta gaagtttagg atatactagt ccgcgagcct 4981 tcaaagccct aagaaaacac acaagtttaa cttctgataa ggactgtaag acttcatcct 5041 acatctattg aatgcaaatc aattgcttta attaagctaa gacctcaact agattggcag 5101 gaattaaacc tacgaaaatt tagttaacag ctaaataccc tattactggc ttcaatctac 5161 ttctaccgcc gaaaaaaaaa aatggcggta gaagtcttag tagagatttc tctacacctt 5221 cgaatttgca attcgacatg aatatcacct taagacctct ggtaaaaaga ggatttaaac 5281 ctctgtgttt agatttacag tctaatgctt actcagccat tttacctatg ttcattaatc 5341 gttgattatt ctcaaccaat cacaaagata tcggaaccct ctatctacta ttcggagcct 5401 gagcgggaat agtgggtact gcactaagta ttttaattcg agcagaatta ggtcaaccag 5461 gtgcactttt aggagatgac caaatttaca atgttatcgt aactgcccat gcttttgtta 5521 taattttctt catagtaata ccaataataa ttggaggctt tggaaactga cttgtcccac 5581 taataatcgg agccccagat atagcattcc cacgaataaa taatataagt ttttgactcc 5641 taccaccatc atttctcctt ctcctagcat catcaatagt agaagcagga gcaggaacag 5701 gatgaacagt ctacccacct ctagccggaa atctagccca tgcaggagca tcagtagacc 5761 taacaatttt ctcccttcat ttagctggag tgtcatctat tttaggtgca attaatttta 5821 ttaccactat tatcaacatg aaacccccag ccataacaca gtatcaaact ccactatttg 5881 tctgatccgt acttattaca gccgtactgc tcctattatc actaccagtg ctagccgcag 5941 gcattactat actactaaca gaccgcaacc taaacacaac tttctttgat cccgctggag 6001 gaggggaccc aattctctac cagcatctgt tctgattctt tgggcaccca gaagtttata 6061 ttcttatcct cccaggattt ggaattattt cacatgtagt tacttactac tccggaaaaa 6121 aagaaccttt cggctatata ggaatagtat gagcaataat gtctattggc tttctaggct 6181 ttattgtatg agcccaccac atattcacag taggattaga tgtagacaca cgagcttact 6241 ttacatcagc cactataatt atcgcaattc ctaccggtgt caaagtattt agctgacttg 6301 caaccctaca cggaggtaat attaaatgat ctccagctat actatgagcc ttaggcttta 6361 ttttcttatt tacagttggt ggtctaaccg gaattgtttt atccaactca tcccttgaca 6421 tcgtgcttca cgatacatac tatgtagtag cccatttcca ctatgttcta tcaatgggag 6481 cagtgtttgc tatcatagca ggatttgttc actgattccc attattttca ggcttcaccc 6541 tagatgacac atgagcaaaa gcccacttcg ccatcatatt cgtaggagca aacataacat 6601 tcttccctca acatttcctg ggcctttcag gaataccacg acgctactca gactacccag 6661 atgcttacac cacatgaaac actgtctctt ctataggatc atttatttca ctaacagctg 6721 ttctcatcat gatctttata atttgagagg cctttgcttc aaaacgagaa gtaatatcag 6781 tatcgtatgc ttcaacaaat ttagaatgac ttcatggctg ccctccacca tatcacacat 6841 tcgaggaacc aacctatgta aaagtaaaat aagaaaggaa ggaatcgaac cccctaaaat 6901 tggtttcaag ccaatctcat atcctatatg tctttctcaa taagatatta gtaaaatcaa 6961 ttacataact ttgtcaaagt taaattatag atcaataatc tatatatctt atatggccta 7021 cccattccaa cttggtctac aagacgccac atcccctatt atagaagagc taataaattt 7081 ccatgatcac acactaataa ttgttttcct aattagctcc ttagtcctct atatcatctc 7141 gctaatatta acaacaaaac taacacatac aagcacaata gatgcacaag aagttgaaac 7201 catttgaact attctaccag ctgtaatcct tatcataatt gctctcccct ctctacgcat 7261 tctatatata atagacgaaa tcaacaaccc cgtattaacc gttaaaacca tagggcacca 7321 atgatactga agctacgaat atactgacta tgaagaccta tgctttgatt catatataat 7381 cccaacaaac gacctaaaac ctggtgaact acgactgcta gaagttgata accgagtcgt 7441 tctgccaata gaacttccaa tccgtatatt aatttcatct gaagacgtcc tccactcatg 7501 agcagtcccc tccctaggac ttaaaactga tgccatccca ggccgactaa atcaagcaac 7561 agtaacatca aaccgaccag ggttattcta tggccaatgc tctgaaattt gtggatctaa 7621 ccatagcttt atgcccattg tcctagaaat ggttccacta aaatatttcg aaaactgatc 7681 tgcttcaata atttaatttc actatgaagc taagagcgtt aaccttttaa gttaaagtta 7741 gagaccttaa aatctccata gtgatatgcc acaactagat acatcaacat gatttatcac 7801 aattatctca tcaataatta ccctatttat cttatttcaa ctaaaagtct catcacaaac 7861 attcccactg gcaccttcac caaaatcact aacaaccata aaagtaaaaa ccccttgaga 7921 attaaaatga acgaaaatct atttgcctca ttcattaccc caacaataat aggattccca 7981 atcgttgtag ccatcattat atttccttca atcctattcc catcctcaaa acgcctaatc 8041 aacaaccgtc tccattcttt ccaacactga ctagttaaac ttattatcaa acaaataatg 8101 ctaatccaca caccaaaagg acgaacatga accctaataa ttgtttccct aatcatattt 8161 attggatcaa caaatctcct aggcctttta ccacatacat ttacacctac tacccaacta 8221 tccataaatc taagtatagc cattccacta tgagctggag ccgtaattac aggcttccga 8281 cacaaactaa aaagctcact tgcccacttc cttccacaag gaactccaat ttcactaatt 8341 ccaatactta ttattattga aacaattagc ctatttattc aaccaatggc attagcagtc 8401 cggcttacag ctaacattac tgcaggacac ttattaatac acctaatcgg aggagctact 8461 ctagtattaa taaatattag cccaccaaca gctaccatta catttattat tttacttcta 8521 ctcacaattc tagaatttgc agtagcatta attcaagcct acgtattcac cctcctagta 8581 agcctatatc tacatgataa tacataatga cccaccaaac tcatgcatat cacatagtta 8641 atccaagtcc atgaccatta actggagcct tttcagccct ccttctaaca tcaggtctag 8701 taatatgatt tcactataat tcaattacac tattaaccct tggcctactc accaatatcc 8761 tcacaatata tcaatgatga cgagacgtaa ttcgtgaagg aacctaccaa ggccaccaca 8821 ctcctattgt acaaaaagga ctacgatatg gtataattct attcatcgtc tcggaagtat 8881 ttttctttgc aggattcttc tgagcgttct atcattctag cctcgtacca acacatgatc 8941 taggaggctg ctgacctcca acaggaattt caccacttaa ccctctagaa gtcccactac 9001 ttaatacttc agtacttcta gcatcaggtg tttcaattac atgagctcat catagcctta 9061 tagaaggtaa acgaaaccac ataaatcaag ccctactaat taccattata ctaggacttt 9121 acttcaccat cctccaagct tcagaatact ttgaaacatc attctccatt tcagatggta 9181 tctatggttc tacattcttc atggctactg gattccatgg actccatgta attattggat 9241 caacattcct tattgtttgc ctactacgac aactaaaatt tcacttcaca tcaaaacatc 9301 acttcggatt tgaagccgca gcatgatact gacattttgt agacgtaatc tgacttttcc 9361 tatacgtctc catttattga tgaggatctt actcccttag tataattaat ataactgact 9421 tccaattagt agattctgaa taaacccaga agagagtaat caacctgtac actgttatct 9481 tcattaatat tttattatcc ctaacgctaa ttctagttgc attctgactc ccccaaataa 9541 atctgtactc agaaaaagca aatccatatg aatgcggatt cgaccctaca agctctgcac 9601 gtctaccatt ctcaataaaa tttttcttgg tagcaattac atttctatta tttgacctag 9661 aaattgctct tctacttcca ctaccatgag caattcaaac aattaaaacc tctactataa 9721 taattatagc ctttattcta gtcacaattc tatctctagg cctagcatat gaatgaacac 9781 aaaaaggatt agaatgaaca gagtaaatgg taattagttt aaaaaaaaaa ttaatgattt 9841 cgactcatta gattatgatg atgttcataa ttaccaatat gccatctacc ttcttcaacc 9901 tcaccatagc cttctcacta tcacttctag ggacacttat atttcgctct cacctaatat 9961 ccacattact atgcctggaa ggcatagtat tatccttatt tattataact tcagtaactt 10021 ccctaaactc caactccata agctccatac caatccccat caccatctta gttttcgcag 10081 cctgcgaagc agctgtagga ctagccctac tagtaaaagt ttcaaacacg tacggaacag 10141 attacgtcca aaatctcaac ctactacaat gctaaaaatt attcttccct cactaatgct 10201 actaccacta acctgactat caagccctaa aaaaacctga acaaacgtaa cctcatatag 10261 ttttctaatt agtttaacca gcctaacact tctatgacaa accgacgaaa attataaaaa 10321 cttttcaaat atattctcct cagaccccct atccacacca ttaattattt taacagcctg 10381 attactgcca ctaatattaa tagctagcca aaaccaccta aaaaaagata ataacgtact 10441 acaaaaactc tacatctcaa tactaatcag cttacaaatt ctcctaatca taaccttttc 10501 agcaactgaa ctaattatat tttatatttt atttgaagca accttaatcc caacacttat 10561 tattattacc cgatgaggga accaaactga acgcctaaac gcagggattt atttcctatt 10621 ttatacccta atcggttcta ttccactgct aattgccctc atcttaatcc aaaaccatgt 10681 aggaacccta aacctcataa ttttatcatt cacaacacac accttagacg cttcatgatc 10741 taacaactta ctatggttgg catgcataat agcatttctt attaaaatac cattatatgg 10801 agttcaccta tgactaccaa aagcccatgt tgaagctcca attgctgggt caataattct 10861 agcagctatt cttctaaaat taggtagtta cggaataatt cgcatctcca ttattctaga 10921 cccactaaca aaatatatag catacccctt catccttctc tccctatgag gaataattat 10981 aactagctca atctgcttac gccaaacaga tttaaaatca ctaatcgcct actcctcagt 11041 tagccacata gcacttgtta ttgcatcaat cataatccaa actccatgaa gcttcatagg 11101 agcaacaata ctaataatcg cacatggcct cacatcatca ctcctattct gcctagcaaa 11161 ctccaactac gaacggatcc acagccgtac tataatcatg gcccgaggac ttcaaatggt 11221 cttcccactt atagccacat gatgactgat agcaagtcta gctaatctag ctctaccccc 11281 ttcaatcaat ctaataggag aattattcat taccatatca ttattttctt gatcaaactt 11341 taccattatt cttataggaa ttaacattat tattacaggt atatactcaa tatacataat 11401 tattaccacc caacgcggca aactaaccaa ccatataatt aacctccaac cctcacacac 11461 acgagaacta acactaatag cccttcacat aattccactt attcttctaa ctaccagtcc 11521 aaaactaatt acaggcctga caatatgtga atatagttta caaaaaacat tagactgtga 11581 atctgacaac aggaaataaa cctccttatt caccaagaaa gattgcaaga actgctaatt 11641 catgcttcca tgtttaaaaa catggctttc ttacttttat aggataatag taatccattg 11701 gtcttaggaa ccaaaaacct tggtgcaaat ccaaataaaa gtaatcaata ttttcacaac 11761 ctcaatctta ttaatcttca ttcttctact atccccaatc ctaatttcaa tatcaaacct 11821 aattaaacac atcaacttcc cactgtacac caccacatca atcaaattct ccttcattat 11881 tagcctctta cccctattaa tatttttcca caataatata gaatatataa ttacaacctg 11941 gcactgagtc accataaatt caatagaact taaaataagc ttcaaaactg actttttctc 12001 tatcctgttt acatctgtag ccctttttgt cacatgatca attatacaat tctcttcatg 12061 atatatacac tcagacccaa acatcaatcg attcattaaa tatcttacac tattcctgat 12121 taccatgctt atcctcacct cagccaacaa catatttcaa cttttcattg gctgagaagg 12181 ggtgggaatt atatctttcc tactaattgg atgatggtac ggacgaacag acgcaaatac 12241 tgcagcccta caagcaatcc tctataaccg catcggagac atcggattca ttttagctat 12301 agtttgattt tccctaaaca taaactcatg agaacttcaa cagattatat tctccaacaa 12361 caacgacaat ctaattccac ttataggcct attaatcgca gctacaggaa aatcagcaca 12421 atttggcctc cacccatgac taccatcagc aatagaaggc cctacaccag tttcagcact 12481 actacactca agtacaatag tagttgcagg aattttccta ctggtccgat tccaccccct 12541 cacgactaat aataacttta ttttaacaac tatactttgc ctcggagccc taaccacatt 12601 atttacagct atttgtgctc tcacccaaaa cgacatcaaa aaaatcattg ccttctctac 12661 atcaagccaa ctaggcctga taatagtgac gctaggaata aaccaaccac acctagcatt 12721 cctacacatc tgtacccacg cattcttcaa agctatactc tttatatgct ctggctcaat 12781 cattcatagc ctggcagacg aacaagacat ccgaaaaata ggaaacatca caaaaatcat 12841 accattcaca tcatcatgcc tagtaatcgg aagcctcgcc ctcacaggaa taccattcct 12901 aacagggttc tactcaaaag acctaattat tgaagcaatt aatacctgca acaccaacgc 12961 ctgagcccta ctaattacac taatcgccac ttctataaca gctatgtaca gcatacgaat 13021 catttacttc gtaacaataa caaaaccgcg ttttcccccc ctaatctcca ttaacgaaaa 13081 tgacccagac ctcataaacc caatcaaacg cctagcattc ggaagcatct ttgcag