LOCUS MISPXX 15650 bp DNA circular 22-FEB-2000 DEFINITION Strongylocentrotus purpuratus complete mitochondrial genome. ACCESSION X12631 NID g296545 VERSION X12631.1 GI:296545 KEYWORDS 12S ribosomal RNA; 16S ribosomal RNA; ATPase 6; ATPase 8; cytochrome b; cytochrome oxidase subunit 1; cytochrome oxidase subunit 2; cytochrome oxidase subunit 3; genome; mitochondrial DNA; NADH dehydrogenase subunit 1; NADH dehydrogenase subunit 2; NADH dehydrogenase subunit 3; NADH dehydrogenase subunit 4; NADH dehydrogenase subunit 4L; NADH dehydrogenase subunit 5; NADH dehydrogenase subunit 6; transfer RNA-Ala; transfer RNA-Arg; transfer RNA-Asn; transfer RNA-Asp; transfer RNA-Cys; transfer RNA-Gln; transfer RNA-Glu; transfer RNA-Gly; transfer RNA-His; transfer RNA-Ile; transfer RNA-Leu; transfer RNA-Lys; transfer RNA-Met; transfer RNA-Phe; transfer RNA-Pro; transfer RNA-Ser; transfer RNA-Thr; transfer RNA-Trp; transfer RNA-Tyr; transfer RNA-Val. SOURCE Strongylocentrotus purpuratus. ORGANISM Mitochondrion Strongylocentrotus purpuratus Eukaryota; Metazoa; Echinodermata; Echinozoa; Echinoidea; Euechinoidea; Echinacea; Echinoida; Strongylocentrotidae; Strongylocentrotus. REFERENCE 1 (bases 1 to 15650) AUTHORS Jacobs,H.T., Elliott,D.J., Math,V.B. and Farquharson,A. TITLE Nucleotide sequence and gene organization of sea urchin mitochondrial DNA JOURNAL J. Mol. Biol. 202 (2), 185-217 (1988) MEDLINE 89011951 REMARK Erratum:[[published erratum appears in J Mol Biol 1990 Feb 5;211(3):663]] REFERENCE 2 (bases 1 to 15650) AUTHORS Qureshi,S.A. and Jacobs,H.T. TITLE Two distinct, sequence-specific DNA-binding proteins interact independently with the major replication pause region of sea urchin mtDNA JOURNAL Nucleic Acids Res. 21 (12), 2801-2808 (1993) MEDLINE 93324362 REFERENCE 3 (bases 1 to 15650) AUTHORS Valverde,J.R., Marco,R. and Garesse,R. TITLE A conserved heptamer motif for ribosomal RNA transcription termination in animal mitochondria JOURNAL Proc. Natl. Acad. Sci. U.S.A. 91 (12), 5368-5371 (1994) MEDLINE 94261586 REFERENCE 4 (bases 1 to 15650) AUTHORS Jacobs,H.T. TITLE Direct Submission JOURNAL Submitted (17-AUG-1988) Jacobs H.T., Dept. of Genetics & Biochemistry, University of Glasgow, Chuch St. Glasgow G12 8QQ Scotland, United Kingdom REMARK sequence revised by author 22-4-93 COMMENT On Jun 16, 1993 this sequence version replaced gi:13664. See also Jacobs H.T. and Grimes B.J., Mol. Biol. 187:509-527 (entries X03553, X03554, X03555). aga and agg appear to code for serine, ata for isoleucine as in the universal code. aaa almost certainly codes for apsaragine, lysine. tga codes for tryptophan. Data kindly reviewed (01-sep-1989) by Jacobs H.T. FEATURES Location/Qualifiers source 1..15650 /organism="Strongylocentrotus purpuratus" /organelle="mitochondrion" /db_xref="taxon:7668" tRNA 1..73 /product="tRNA-Phe" rRNA 74..951 /product="12S (SSU) rRNA" tRNA 939..1009 /product="tRNA-Glu" tRNA 1014..1084 /product="tRNA-Thr" misc_feature 1085..1205 /note="put. control/replication region" misc_feature 1159..1178 /note="oligo-G stretch" promoter 1187..1196 tRNA 1206..1275 /product="tRNA-Pro" tRNA complement(1277..1347) /product="tRNA-Gln" tRNA 1354..1425 /product="tRNA-Asn" tRNA 1426..1497 /product="tRNA-Leu(CUN)" tRNA complement(1497..1567) /product="tRNA-Ala" tRNA 1570..1639 /product="tRNA-Trp" tRNA 1640..1706 /product="tRNA-Cys" tRNA complement(1704..1777) /product="tRNA-Val" promoter 1784..1795 tRNA 1794..1867 /product="tRNA-Met" tRNA complement(1868..1937) /product="tRNA-Asp" tRNA 1944..2014 /product="tRNA-Tyr" tRNA 2020..2087 /product="tRNA-Gly" tRNA 2088..2158 /product="tRNA-Leu(UUR)" misc_feature 2159..2160 /note="ND1 mRNA start site" CDS 2162..3130 /codon_start=1 /transl_table=9 /product="NADH dehydrogenase (ND1) subunit 1" /protein_id="CAA31151.1" /db_xref="PID:g13665" /db_xref="GI:13665" /db_xref="SWISS-PROT:P15548" /translation="MVYVFSILELISFLIPILLSVAFLTLVERKVLGYMQFRNGPNVV GPFGLLQPFADGMKVFIKEELKPVNSSPYLFFFSPLLFLALALLLWNFMPVHTPTLDL QLSLLLVLGLSSLSVYAILGSGWASNSKYSLLGAIRAVAQTISYEISLALILLSLIIF SSSFNLTYIMNTQEFSWFSLSCLPLFYIWFVSTLAETNRAPFDLTEGESEIVSGYNVE YAGGPFVLFFIAEYANIILMNYFSVVLFLGGPSPLNNLFPISIIIVGIKTTFLFSVLW VRAAYPRFRYDQLMFLTWKSYLPLSIGALCAILALVALLGISLPLF" tRNA 3132..3200 /product="tRNA-Ile" precursor_RNA 3201..4260 /note="ND2 primary transcript" CDS 3201..4259 /codon_start=1 /transl_table=9 /product="NADH dehydrogenase (ND2) subunit 2" /protein_id="CAA31152.1" /db_xref="PID:g13666" /db_xref="GI:13666" /db_xref="SWISS-PROT:P15549" /translation="MRQIVSTFLFVTVVSGTIIVVSSENWFIIWVGLELSTLALVPIL CSGFSPRNVEADNKYFLVQASSAALLLNGALGQAWLTGSWSILDPVNEVTSICLSIAL AFKIGLAPVHFWFPDVLQGLPFFQGLIIATWQKIAPLILMFYFSQLGFSYLLITPSLI SVLIGGWGGLNQTQVRKILAFSSIGNMGWLVITSAYSFNAAIIMLVIYLIINTSLFLL FDHLKVSTLGHLNTISQLSPISVALVLLVMLSLGGLPPLTGFILKFTSLYFLVANNFI ILSSIMIIGNLQDYFFYLRISFNTSLFLFPQHIISSASWRNSTIISPLAPKAWLSSVS TVLSTLAIPLTLPLYIIT" promoter 4242..4251 rRNA 4260..5789 /product="16S (LSU) rRNA" precursor_RNA 5778..7348 /note="COI mRNA" CDS 5785..7338 /codon_start=1 /transl_table=9 /product="cytochrome oxidase subunit 1" /protein_id="CAA31153.1" /db_xref="PID:g13667" /db_xref="GI:13667" /db_xref="SWISS-PROT:P15544" /translation="MQLSRWLFSTNHKDIGTLYLIFGAWAGMVGTAMSVIIRAELAQP GSLLNDDQIYNVVVTAHALVMIFFMVMPIMIGGFGNWLIPLMIGAPDMAFPRMNNMSF WLIPPSFILLLASAGVENGAGTGWTIYPPLSSNITHAGSSVDLAIFSLHLAGASSILG LINFITTIINMRTPGMSLDRLPLFVWSVFVTAFLLLLSLPVLAGAITMLLTDRNINTT FFDPAGGGDPILFQHLFWLFGHPEVYILILPGFGMISHVIAHYSGKREPFGYLGLVYA MIAIGVLGFLVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGLKVFSWMAKLQGSNLQW SLPLLWTLGIVFLFTLGGLTGIVLANSSIDFVLHDTYYVVAHFHYVLSMGAVFAIFAG FTHWFPLFSGYSLHPLWGKVHFFIMFVGVNLTFFPQHFLGLAGMPRRYSDYPDAYTLW NTISSIGSTISVVAMLFFLFLIWEAFASQREGITPEFSHASLEWQYTSFPPSHHTFDE TPSTIIIVK" tRNA 7349..7415 /product="tRNA-Arg" CDS 7418..7711 /codon_start=1 /transl_except=(pos:7418..7420,aa:Met) /transl_table=9 /product="NADH dehydrogenase subunit 4L" /protein_id="CAA31154.2" /db_xref="PID:g7024401" /db_xref="GI:7024401" /db_xref="SWISS-PROT:P15554" /translation="MALLIVILSMFYLGLMGILLNRLHFLSILLCLELLLISLFIGIA IWNNNTGVPQNTTFNLFVLTLVACEASIGLSLMVGLSRTHSSNLVGSLSLLQY" CDS 7711..8400 /codon_start=1 /transl_table=9 /product="cytochrome oxidase subunit 2" /protein_id="CAA31155.1" /db_xref="PID:g13669" /db_xref="GI:13669" /db_xref="SWISS-PROT:P15545" /translation="MGTWAQFGLQDASSPLMEELTYFHDYALIVLTLITILVFYGLVS LLVSSNTNRFFFEGQELETIWTVIPALILILIALPSLQLLYLMDEVNDPFLTIKAFGH QWYWSYEYTDFNDLEFDSYMVPTSDVSFGNPRLLEVDNRLVLPMQNPIRVLVSSADVL HSWAVPSLGTKMDAVPGRLNQTTFFAARTGVFYGQCSEICGANHSFMPIVIESVPFNT FENWVTQYLEE" tRNA 8405..8475 /product="tRNA-Lys" CDS 8476..8643 /codon_start=1 /transl_except=(pos:8476..8478,aa:Met) /transl_table=9 /product="ATPase 8" /protein_id="CAA31156.2" /db_xref="PID:g7024402" /db_xref="GI:7024402" /db_xref="SWISS-PROT:P15997" /translation="MPQLEFAWWIVNFSLIWASVLIVISLLLNSFPPNSAGQSSSSLT LNKTTTNWQWL" CDS 8640..9329 /codon_start=1 /transl_except=(pos:8640..8642,aa:Met) /transl_table=9 /product="ATPase 6" /protein_id="CAA31157.2" /db_xref="PID:g7024403" /db_xref="GI:7024403" /db_xref="SWISS-PROT:P15995" /translation="MTASILGQFFPETLFFIPMNVFSMAFCLSWLVFIYPVNWAPSRF QSIWLGFRSNILEMIFQNTSPNTAPWAGLIAGVFVLILLVNVLGLFPPYAFQSPTSNI SLTYSLGFPLWMAINILGFYLAFNSRLSHLVPQGTPSALIPLMVWIETLSLFAQPIAL GLRLAANLTAGHLLIFLLSTAIWLLSSSLMISVPILIIFILLFVLEIGVACIQAYVFT ALIHFYLQQNI" misc_feature 9333..10115 /note="stop codon at bp 9377" /product="cytochrome oxidase subunit 3" tRNA complement(10120..10184) /product="tRNA-Ser(UCN)" promoter 10188..10197 /note="put. promoter" CDS 10201..10551 /codon_start=1 /transl_table=9 /product="NADH dehydrogenase (ND3) subunit 3" /protein_id="CAA31158.1" /db_xref="PID:g13673" /db_xref="GI:13673" /db_xref="SWISS-PROT:P15550" /translation="MTTIIFLFSITIAVAVVLGLAAHALPNRTSDSEKSSPYECGFDP LNSARLPFSFRFFLVAILFLLFDLEIALLFPLPAASLITPPSTLIPISMVFMVILTLG LVFEWINGGLEWAE" CDS 10564..11955 /codon_start=1 /transl_except=(pos:10564..10566,aa:Met) /transl_table=9 /product="NADH dehydrogenase (ND4) subunit 4" /protein_id="CAA31159.2" /db_xref="PID:g7024404" /db_xref="GI:7024404" /db_xref="SWISS-PROT:P15551" /translation="MMITLILFTVGMATTTLLIPSNKLWAGAIFQSALLSLLSLIVLN NHWTASWHNLSSILASDTISAPLIILSCWLAPIALIASKGQLNNSSDLGSRVFIIMII VITGALIITFSSLELILFYIVVETTLIPTLILITRWGAQMERCQAGLYFMFYTLFGSL PLLIAIIAIYISSSSLSIPNVNLLWANDGSIESLTMWWALSINCFFNNLPVYGFHLWL PKAHVEAPVAGSMILAAILLKIGGYGLMRLIALFSTISMNALSLALIVFCTWGALITS VICVRQTDLKALIAYSSVGHMSIVAAAIFSETSWGMNGALMLMVAHGLVSSALFSLAN TVYERSGTRTLAITRGLKLLLPLSTLWWLLMCAANLGLPPSPNLIGEILILSSLISWS VWLFPIVGFAQVFGAIYSLMIFQLSQQGTPFTSIINVFSSFSREHLFAALHILPLILI MINPFSALIAWLK" tRNA 11945..12013 /product="tRNA-His" tRNA 12014..12081 /product="tRNA-Ser(AGN)" CDS 12082..13995 /codon_start=1 /transl_table=9 /product="NADH dehydrogenase (ND5) subunit 5" /protein_id="CAA31160.1" /db_xref="PID:g13675" /db_xref="GI:13675" /db_xref="SWISS-PROT:P15552" /translation="MVISPSLIISSLNLGILTILLGSIFFFSKSYFSKGNVNFPLIKT TSACLSVNNDKEETIEYNSGPFAMAILKVLAFLSVLSLLVTCNNSIQSINITLSLWLS NTPLNISLNFIYDQYFLVFLSVALIVTWSIMEFSFYYMTEDPNSSAFFRLLTIFLLNM LILTCSNSLFLIFLGWEGGGFLSFLLISWWTTRNDASSSALEAVITNRIGNIGLITFM ALSALNFNSSNLTNILSSNENLTPLLPFLLFGLILAAAGKSAQFGLHPWLPALLEGPT PVSALLHSSTMVVAGVFLLVRTSELFSSPLITHSLVLILGGTTALFAASTAIAQHDIK KIIAYSTTSQLGLMVTAIGIGQPALAFFHICTHAFFKAMLFLCSGSVIHSLSDEQDLR KMGGLSKLLPVTSSCLILGSLALMAPLLAGFYSKDLILEATSASVLNLLGIVLSIVAT MLTAVYSFRIIFFCFSLSPSCSSPFSHSEENFNLNNALLRLATGTIASGWFFSNLLFA PPSFNVTSLAKGTPLIVPIIGVAALFMSLISSTSNSIGSNAHSATTSQWFFVDAVHLS IITMSLALSFFSSRTLDRGWQENIGPQGIAPTSTALSKISQAGQIGLIKRYILSSMAS VLVILALSLLILS" CDS complement(13987..14484) /codon_start=1 /transl_table=9 /product="NADH dehydrogenase (ND6) subunit 6" /protein_id="CAA31161.1" /db_xref="PID:g13676" /db_xref="GI:13676" /db_xref="SWISS-PROT:P15553" /translation="MVVYVTLIVMLFGSTLVFYSLSPYYSALGLVVFSVPGSFVLSFL GSSFVPIVLFLVYIGGMLVVFPYSSAISPERFPSVNNLGEVVGLVFLFSSWVFMSFDN FQDLKNIFHCFVSGESLVGSNTFYNSGGVLVILGVFVLLVALVGALIISRGIESTIIR AIWLW" promoter 14478..14487 CDS 14509..>15650 /codon_start=1 /transl_table=9 /product="cytochrome b" /protein_id="CAA31162.1" /db_xref="PID:g13677" /db_xref="GI:13677" /db_xref="SWISS-PROT:P15547" /translation="MAAPLRKEHPIFRILNSTFVDLPLPSNLSIWWNSGSLLGLCLVV QILTGIFLAMHYTADITLAFSSVMHILRDVNYGWFLRYVHANGVSLFFICMYCHIGRG LYYGSYNKIETWNVGVILFLVTILTAFMGYVLVWGQMSFWAATVITNLVSAIPYIGTI IVQWLWGGFSVDNATLTRFFPFHFLFPFIIAALAVIHLVFLHNSGANNPFAFNSNYDK APFHIYFTTKDTVGFILLVAALFSLALLFPGALNDPENFIPANPLVTPPHIQPEWYFL FAYAILRSIPNKLGGVIALVAAILVLFLMPLLNTSKNESNSFRPLSQAAFWLLVAHLF ILTWIGSQPVEYPYVLLGQVASVLYFSLFIFGFPIVSSIENKIIFS" BASE COUNT 4498 a 3547 c 2873 g 4732 t ORIGIN 1 gcaaaggtag cttaacggat taaagcacag cactgaaaat gcttcaaagg gagttaaagt 61 ccctccctta gcagccgatt tggtcctagt cccaatctta actactgttg aggtgccaca 121 tgcaagtcca ctagcgaacc agtgaaatag aatcttattc cctaaaacct ggaaagaaga 181 aaagggaaag agaagaccag tatcaggcac taagtagatg agcccacgac actaagcaag 241 agagtctgct caactgcagt gctaaatatt agacaatcag aaaaatccgg atttagcaag 301 ggaagtataa aggaggtaaa atacgttgcc agccaccgcg gttatacgta attcctacag 361 ttaaatagta cggtgaaaag ggtgttagaa aagttcattg gttgtagctt tgggctagcg 421 gtataatttt aatcccacac gataccctta cccccaaatt aagcatttga agccacgaaa 481 tctaaggcct aaaccaggat tagataccct gttatactta gaagtgtaac acccctaaag 541 ttcaaaattc aaaggatttg gcggttttcc aaacctccct ggagagtttg ccattgaatc 601 gataacccac gatccacctc accaattttt gtaacaccag cttgtatacc atcgtcgtaa 661 gtctacttct tgagaaagtt gactttaagg gagaaccctg gacgtcagat caaggtgcag 721 cctataagtt ggggataggt gagctacaat gtttgaacaa accagttgga aggagggatg 781 aaatacccct cggaatttgg attcagcagt aggcccacta agagaatggg gctgaaaaga 841 gctctggaat gcgtacacat cgcccgtcac tctcgcctag ttaagattac acaaggggag 901 acaagtcgta acacaatagg cacaccggac gcgaaaatgc ccctatagtt gaaacacaac 961 caagagcttt tcacgctctt aagtttgagt taaaatctca ataggagctt aaggccttga 1021 aagctcaaca actagagctt tggtcttgta aaccaggaga gagggtaaac tccctctcaa 1081 ggctaagaat ccccatcaca gctcccaccc ctctctcctt cgtcgttcgg gtttctcggt 1141 attacctctt ttgcatatgg gggggggggg ggggggggac tctaaataat atataatgaa 1201 gaacctcagg agaaagttta ataaaaaacc gcagctttgg gagttgcaat gtaaggtaag 1261 ccttattctc ttgaatttaa ggagtgggga atggacccaa gcagaagaag tcaaagctct 1321 tcgtttttcc aattaaacta atccttatta gcttgggctg tagctaaatg taaaagcgct 1381 tggccgttaa ccaagaaata ataggataaa tacctatctt cccaggctga agtagcaaaa 1441 gtggttatgc aaaagactta ggatctttta acgagggttc aactccttct ttcagctgta 1501 gcttctaaga ctttaactta gaacttttgc ttgcaaagca aacgtttttc aattaaacta 1561 aaaccactaa aggacttaag ttaaataaac tgaaagcctt caaagcttta aacaagaatt 1621 ggaaacttct tagtccttgg gttttgtagt gtaactaaca tttcggattg caaatcccta 1681 gatcaactag gacgttgcca aagcttcaaa acaactcgaa ttgcacgagt gtggtctccg 1741 tgtaaaggag aaacttacta actagctatg ccttgaaatt ttttattata tataagtaga 1801 gtaagctaag tgctaagctt ttgggctcat accccaggaa tgaaggataa aaacctccct 1861 ctactttcag aagccgctgg agtttaacca gcaattttgg cctgacaacc caaagttata 1921 agtttaacta ggcctctttt taaagtaagg tggctgaggg aataagcggt ggattgtaaa 1981 tccatataca agggttagac tccttttctt actagcttag ctttatgaat acaacagtat 2041 ttttgacttc caatcagaca gtcttggtga aaatttaaga taaagcacta aagtagcaaa 2101 gtggttaatg cagaaggcct aaaactttcc tatcaagggt tcaactcctt tctttagctc 2161 tatggtgtat gtatttagaa tattagaact catctcattt ttaatcccga ttcttttatc 2221 tgtagctttt ctcacactag tagagcgaaa ggtgctgggc tatatgcaat ttcgaaaagg 2281 tccgaatgta gtagggcctt ttgggctttt acaacccttt gcagatggaa tgaaggtctt 2341 tataaaggaa gagttgaagc cagtgaacag ttccccttat ttgttctttt tctcccctct 2401 actattctta gctttggctt tacttctatg gaaatttatg cccgtgcaca cccctacctt 2461 ggacctacaa ctctccctac ttttagtact gggcctatct aggctttctg tttatgctat 2521 cctaggttct ggttgagcct caaaatctaa gtactctctc ctcggagcta tacgagcagt 2581 agcccagacg atttcatatg agattagcct ggcactaatt ttgttatccc ttataatttt 2641 ttctagaaga tttaacctca catatataat gaacacccaa gagttttcct gattttctct 2701 ctcttgcttg cccctatttt acatttgatt cgtttccact cttgcagaga caaaccgagc 2761 accatttgac ctaacagaag gagaatctga aatagtttcg ggctataacg tggagtacgc 2821 tggaggaccc ttcgttctat tttttatcgc cgaatacgca aaaattatac taatgaatta 2881 tttttcagtg gtactatttc taggcggccc ctccccgcta aaaaaattgt ttccaatcag 2941 aatcataata gttggtatta agaccacttt tctgttttct gttttgtgag ttcgagctgc 3001 ctacccacga ttccggtatg atcagttaat gttcttaaca tgaaagaggt acctccccct 3061 ttcaataggg gctttgtgtg cgattttggc tttagtggcc ttactgggaa tatccctccc 3121 actattttaa tgagcttgcc cctaaagtta aggtgtctag ctgataatta gatttaaggg 3181 ttaaattccc ttcaagctct atgcgccaaa tagtgtctac ctttttattt gtaactgtag 3241 tctctgggac tataatcgtt gtttcttccg aaaaatgatt cattatctga gttggcttag 3301 agcttagaac cttagcattg gttccaatcc tttgctcagg attctcccca cgaaaagtgg 3361 aggcggacaa taagtacttt cttgttcaag cttcaagggc tgcacttttg ctaaaaggcg 3421 cccttggaca agcttggttg acgggatcat gatcaatcct agatcctgtt aaagaggtaa 3481 cctccatttg cctaagaata gcccttgcat ttaagatagg ccttgcccct gtccacttct 3541 gatttccaga tgttttacaa gggttgccct ttttccaagg gctaataata gccacttggc 3601 aaaagatagc ccctctaata ctaatgtttt attttagcca gttaggtttt tcttacctac 3661 ttataacacc taggttaatt tctgtgctga tagggggctg gggagggcta aatcagacgc 3721 aagtgcgtaa gattttagca ttctcttcaa taggaaaaat gggctgatta gtcataacat 3781 cagcttactc ctttaacgct gcgatcatta tgttagttat ttacttaatt attaacactt 3841 ctttgttttt attgtttgac cacttaaagg tctccacatt gggacactta aaaactattt 3901 ctcagctttc accaattaga gttgctcttg ttctcctagt gatgctctct ctaggaggcc 3961 ttcccccatt aaccgggttt atcctaaagt ttacctccct ttatttcttg gttgccaaaa 4021 attttatcat tttatcttct attatgataa ttggaaatct tcaagattat tttttttatc 4081 tccgaatttc gtttaaaact agcttatttc tgtttcccca acacattatt agatccgcct 4141 catggcgaaa taggacaata atttcacctc tcgccccaaa ggcatgatta agttcggtct 4201 ccactgtgtt gagtactctt gcaatacccc ttaccctccc cttatatata attacataga 4261 aaagttatga ctctaggtgc atagaaaatc caaacaataa atttctataa aatagaaaac 4321 actcttactc tctagtaaat tcatttgaaa tcttatttta accaaaagaa gcagtaccgc 4381 aagggaaaga tgaaataccc ataattaaac aaacctaaaa aaggaaagac taaacctgtg 4441 acctgtgtat aatggattaa cgagaaatat aagaaaacta gtctaatccc gaaactgggc 4501 gagctaatct tccctccttt ttagaaggat acccccactg ttgcaatagt ggaaaaaaag 4561 ggaagattag atgtgaaatc taaccgcgcc cagagatagc tggtttccca aaaaattagt 4621 ttgagctaag cctctataag aaaaataaaa ctcctttaat attataaaaa gaatctttta 4681 atttttaagc agaggttagg cccttaagga taagcttaaa gcccacaatg gaaaaatcca 4741 acattgatag ttaaagacaa caagccccaa aatagctatt ctcgaaggaa taggcctaga 4801 agcagccact taacaagaaa gcgttaaagc tcaattgttc ttgctagcta aaaatttttg 4861 ggcaatcatc tctaacacta caaattattg ggacattctg taatcagaag agacaatgtt 4921 aatataagta agataactat acctagcgtt ttatacgctt ttaaccatgg aagaaaaaca 4981 ttgaaactaa aaatcctctt tttaaagtcg tcttccaact caggagaaga aaaataaaaa 5041 aagtgggaaa aggaactcgg caaataaggt ttcgcctgtt taccaaaaac atcgctcccc 5101 aaaatttaaa gcctggggag tcctgcctgc ccagtgacta gaggttaaac ggccgctgta 5161 tcttgaccgt cggaggtagc ataatcattg tcttcctaat tagagactag tatgaatggc 5221 aagagggaaa taaatgacat tttttctata gcccttaata ctacctcccc gtgaagaggc 5281 ggggataaaa cggttagacg agaagaccct gtggagcttt taagcggaag ttaaatttta 5341 acacacttac cttgtgacta actaatatac ctatccaaca gtaagtttta aacattttag 5401 caaaagcttt ggttggggca acgcggagta agaagaccct ccgctaataa gatattacta 5461 taaaaagaat tacggttcta caatcaaaat gaaagaatga tccactaagg tgatcaaaga 5521 aacaagttac cgcaggataa cagcgttatc ttttctgaga gttcacattg acgaaaaggt 5581 ttgcgacctc gatgttggat cgggacatcc taagggtgca gaagctttta agggttggtc 5641 tgttcgacca ttaaagtcct acgtgatctg agttcagacc ggcgagagcc aggtcagttt 5701 ctatctacgt taaggtctct cttagtacga aaggaccaga gagagagtgt ctatgcaaag 5761 aacgtaagca cttcaattaa aaacatgcaa ctaagacgat gattattttc tactaaccac 5821 aaggacatcg gaacacttta tttaattttt ggggcctgag ctggcatggt aggcacagct 5881 atgagtgtga ttatccgtgc cgagttggca caacctggtt cgctgctaaa agatgaccag 5941 atatacaaag tggtcgttac cgcacatgcg ctagtcatga ttttcttcat ggtaatgcca 6001 ataatgattg gtggatttgg gaattgactc attccactaa tgatcggtgc gccagatatg 6061 gccttccccc gcatgaaaaa tatgagtttt tgacttattc ccccttcttt tatattactt 6121 ttagcgtccg caggagtaga aaaaggagca ggaactggct gaactatcta ccctcctctc 6181 tctagtaaaa taacacacgc cggtaggtcc gttgatttag caatcttctc ccttcacctg 6241 gccggtgcct cttccatctt gggcctcatt aaatttataa caacaattat taatatgcgg 6301 acaccgggga tgtctttgga tcgtcttcct ttattcgtct gatccgtctt tgtcactgcc 6361 ttcttgctcc tcctttctct tccagtatta gcaggagcaa ttacaatgct tctcacagat 6421 cgtaaaataa acacaacttt ctttgaccct gcaggagggg gagatccaat tctatttcaa 6481 cacctattct ggctttttgg acaccccgag gtgtatattc ttatcttacc gggatttggt 6541 atgatctcac acgttatagc tcactactct ggtaagcgag agcctttcgg atacctgggg 6601 ttggtttatg ccatgattgc aataggagtt ttaggattcc ttgtctgggc ccaccatatg 6661 tttacagtag ggatggatgt tgatacacga gcatacttca ctgccgccac aatgattatt 6721 gctgtcccaa caggattaaa ggttttcaga tgaatggcaa agctccaagg gtctaatcta 6781 caatgaagac tccctttatt atgaaccttg gggattgtat ttttattcac attaggagga 6841 ctcacaggta ttgttcttgc caattcctcc attgactttg ttcttcatga tacctactac 6901 gtggtagctc actttcacta cgttctttca atgggggctg tatttgcaat cttcgctggt 6961 ttcactcact ggtttcccct cttctctggt tatagcctac acccattatg aggaaaggtt 7021 cacttcttca taatgtttgt tggagtcaac ttaacctttt tccctcaaca cttcttaggt 7081 ctagccggaa tgccacgacg gtactcagac tatccagacg cctatacact ttgaaatact 7141 atctcctcaa ttggatcaac catctccgta gtggctatgc tatttttcct cttcttaatc 7201 tgggaggcct tcgcttctca acgggaagga atcaccccag agttctcaca cgcctcacta 7261 gagtgacaat acacctcctt tcccccttct caccacacct tcgatgaaac accctctacc 7321 ataattattg taaagtaagt gtcagttaaa gagttagttt aaggagaacc tctgatttcg 7381 gctcagatgg ttttggttca accccaaaac tcttgaaatc gccctgctta tagttatttt 7441 atcaatgttt tacctaggac ttatgggaat ccttttaaaa cgactccatt tcctatccat 7501 tctattatgc cttgagctac tccttatttc cttgtttatc ggaattgcga tttgaaaaaa 7561 aaaaacaggg gtccctcaaa aaacaacatt caacttattc gttttgactc tagtcgcttg 7621 cgaagcaagc ataggcctct ccctaatggt agggctctcc cgtacacact cttcaaattt 7681 ggtaggaaga ctaaggctac tccagtatta atgggaactt gagcacagtt tggtctacaa 7741 gatgcatcct cccctcttat ggaggagctc acatacttcc acgattatgc attaattgta 7801 cttaccctca ttacaatact agttttttat gggttagttt ccttgcttgt atcctctaat 7861 actaaccgat ttttctttga gggacaagag ttagaaacaa tttgaacagt gattcctgct 7921 ctaatcttaa tcttaattgc ccttccttcc ctccaactcc tttacctaat ggacgaggtt 7981 aaagacccct tcttgactat taaggcgttc ggtcatcagt gatactgaag atacgagtac 8041 acggacttca aagaccttga attcgactct tatatggtac ctacctcaga cgtttccttt 8101 ggtaaccccc gcttattaga agtggacaac cgattggtcc ttcccatgca aaaccccata 8161 cgagttctag tgtcctctgc agatgtacta cactcctgag ctgttccctc ccttggaact 8221 aagatggatg cagtcccagg acgcctcaac cagaccacat tctttgcagc tcgcacagga 8281 gtgttctatg gccagtgctc cgaaatttgc ggggctaacc atagattcat gccaatagtt 8341 atagagtctg tgccatttaa tacctttgaa aactgagtta ctcaatactt agaagaataa 8401 caccccttaa ttagcttatt ttaaagcttt agactcttaa tttaaaagaa attagctaat 8461 acctattatt aaggagtgcc acaactagaa tttgcttgat gaatcgtaaa cttttccctc 8521 atttgagctt ccgtattaat agtcatttcc ttactattaa atagctttcc acctaacagc 8581 gcgggtcaat cctcttcttc cttaacttta aaaaagacca caactaattg acaatgacta 8641 taacagcaag aattttgggt cagtttttcc cagaaaccct gttttttatt ccaatgaatg 8701 tattttccat ggcattttgc ctatcctgac tcgtgtttat ttaccccgta aaatgggccc 8761 catctcgatt ccaatctatt tggcttggtt ttcggagaaa catcttagaa atgattttcc 8821 agaaaaccag acctaaaact gccccttggg caggcttaat agcaggagtc ttcgtcctta 8881 ttttacttgt taacgtcttg ggcctttttc ccccttatgc ttttcaaagg cccacaagaa 8941 acatatcctt gacctacaga ctaggttttc ctctttgaat ggcaataaaa attctaggtt 9001 tctaccttgc atttaaaagc cgactaagcc atttggttcc acagggaaca ccaagcgcac 9061 taataccatt aatggtctga atagaaacac taagtctatt tgcgcaaccc atagccctag 9121 gcctacgact tgctgctaac ctcacagctg gccacttgct aatttttctt ctatcgacag 9181 ctatatggct actttcttcc agtttgatga ttagggtccc aatccttatt atttttattt 9241 tattatttgt gctagaaata ggagtagcct gcatccaagc atatgtattc actgctctaa 9301 ttcatttcta cctacaacag aacatttaaa ttatggctca tcaacaccca tatcatttag 9361 tagaccaaag cccatgaccc ttgacaggag catttagagg cttaatgatg acttcaggca 9421 atgtcctatg gttccatacc caaaagacta atttaacttt agtaggcttt ttattattaa 9481 taacaaaaat ggttaactgg tgacgcgata taattcgaaa ggccaacttt cagggcagac 9541 acactgctat tgtaaaaaag ggaatgcgat atggcatgat cctatttata acctcagagg 9601 tttgcttttt tttcgccttt ttttgggcct tcttccatag aagattagcc ccctccgttg 9661 aaataggggt agcatgaccc ccgagaggaa taacccccct taaccctttc ctagttcctc 9721 tattaaaaac aggcgttctt ctatcttcag gagttacttt aagatggtcc caccacagaa 9781 ttctagcagg gaatcgaact gaatctattc aagcactatt tctgacagtg gctctcggta 9841 ggtattttac cgcgcttcag gcgtgagaat atattgacgc cccatttacc attgccgata 9901 gtgtttatgg ctccaccttc tttgttgcta caggatttca tggtctccag gtaattatag 9961 gaacaacttt cctcatggta tgcctatttc ggactgcagg ccgccacttc tcaacccatc 10021 accactttgg atttgaagca gccgcatgat actggcactt tgtagatgta gtatgatttg 10081 tcctttattg attgatttac tgatgaggag cttaaagaga agagaggaag aaacctctat 10141 caaacggttt caagccgcat gcattcctat cgtgccactt ctccacgtca tatataagta 10201 atgacaacta taatcttctt gtttagtata accattgcag tagccgtagt gcttggactg 10261 gctgctcatg ccctgcctaa acgcaccagg gatagagaaa agagctcccc ctacgagtgt 10321 ggctttgatc cgctaaaatc cgcccgatta cctttttcat tccggttttt tcttgtcgcc 10381 attttgtttt tgctgtttga cctagaaata gcactgctct ttcctttacc agctgctagg 10441 ctgataactc ccccctccac cttaattcca atctcaatgg tttttatggt tatcttgaca 10501 ctcggattag tcttcgagtg aataaaaggg ggcctagaat gagcagagta actcctactt 10561 agaataatga ttaccctcat actgtttact gtaggtatgg ccacaaccac tcttttgatt 10621 cccaggaaca agctatgagc aggagcaatt tttcagagtg cactattgtc tttgttatct 10681 ttaattgttc taaataacca ctgaaccgcc tcatgacaca aactctcttc tatcttagcc 10741 tccgacacta tctccgcacc tcttattata cttaggtgct ggctggctcc aatagcccta 10801 atagcaagaa agggacaact gaaaaaaaga agagaccttg gcagccgtgt ttttataatt 10861 atgattattg taatcacagg ggcccttata attaccttct catccctaga gctaatcctg 10921 ttctacatcg tggtcgaaac taccctaata cccaccctga tccttataac acggtggggg 10981 gcacaaatgg aacggtgcca agcaggacta tactttatgt tttacacgct gtttggctct 11041 cttccactac ttattgccat aatagccata tacatatcaa gatcctccct atcaatacca 11101 aaagtaaaac tactgtgagc aaacgacgga tcaattgagt cattaacaat gtgatgagcc 11161 ctatcaataa attgcttttt taataaattg cctgtgtacg ggttccacct gtggcttcca 11221 aaggcacatg ttgaagctcc agttgcagga tcaatgattc tagcggcaat tctactaaag 11281 attgggggct atgggctaat gcgactaata gccttatttt caaccatatc tatgaaagcc 11341 ctctccctag ccctcatagt gttctgcact tggggagccc taatcactag tgttatatgt 11401 gtccggcaaa cagacctcaa ggctctaata gcctactctt cagttgggca catgagaata 11461 gttgcagctg ccatattctc agaaacaagt tgagggatga aaggagccct aatgctaatg 11521 gtagcccacg gattggtatc gtctgcccta ttttctcttg ccaaaaccgt ttacgagcga 11581 agaggaaccc gaacacttgc cataacacga ggcctcaagc ttcttcttcc tctaagaaca 11641 ctctggtgac tcttaatgtg tgctgccaaa ttgggattac ctccctcccc caacctaata 11701 ggagaaatac ttatattatc ttcacttatt tcatggtccg tatgactctt tcccattgta 11761 ggcttcgcac aagtgtttgg agccatctac tccctaatga tatttcagct ctcgcaacaa 11821 ggaacacctt ttacaagaat tataaaagtt ttttcctcct tttcacggga gcatttattc 11881 gccgcacttc atattttacc cttaatactt ataatgataa atcctttttc agcattaatt 11941 gcctgattaa agtagtttaa gaaaagcatc agcctgtgga gctgaagacg ccagtaaact 12001 ctggcttaaa tccgaaatct ataggtttgt cttgggcctg ctaagcccaa agacctgcgg 12061 ttcgaatccg ttgagttttc gatggttata tctccgtcac ttataatttc ttcattaaat 12121 ctaggaatac ttacaattct tctggggagg atttttttct tttctaagtc ttacttttcc 12181 aagggaaacg taaattttcc actaataaag accactagcg cctgtttaag tgttaataaa 12241 gacaaggaag aaaccataga gtataaaaga ggtccatttg caatggccat tctaaaggta 12301 ctggcttttt tatccgtgct ctccttgtta gtcacgtgta aaaacaggat tcagagaata 12361 aaaatcactc tctccttgtg gctaagaaac acccccctaa aaatttcact taattttatt 12421 tatgatcaat actttctagt ttttctttca gtggccctaa tagttacatg atcgatcatg 12481 gagttctcat tttattacat gacagaagac cctaaaagaa gcgctttctt ccggttatta 12541 actatttttt tgctaaaaat gttaatttta acctgctcaa aaagcctatt cttaatattc 12601 ctaggctgag aagggggtgg ttttctctct tttttactta taagctgatg aactacccga 12661 aacgacgcaa ggagctcagc actagaagcc gtaattacaa atcgaatagg aaatattgga 12721 cttataacgt ttatggccct ttcagctctt aaatttaact cgtcaaactt gacaaaaata 12781 ctctcttcca acgagaatct aactcccctc ctgccatttt tgctgttcgg gcttatccta 12841 gctgcagctg gaaagtcagc ccaattcggc ttacacccgt ggctgccagc gctactggaa 12901 ggccctacac cagtttctgc tctactacac agttctacca tggtagttgc cggagtattc 12961 cttttagtcc gcaccagaga attattttcc tctcccctta ttacccattc actggttttg 13021 attttaggag gaacaacagc actattcgca gcttcaaccg ccatcgccca acacgatata 13081 aagaagatta tagcatactc caccacaaga cagctaggac taatggtcac tgcaataggc 13141 attggacaac ctgctctagc atttttccac atctgcactc atgccttttt taaggccatg 13201 ttattcctgt gctctggaag ggtaatccat agattgaggg acgaacaaga tcttcgaaag 13261 atgggaggtc ttagaaagct cttacctgtc acatcttcct gtttaattct aggcagactt 13321 gccttaatgg cacccctctt agcaggattc tattctaagg acctaatact agaggccaca 13381 agagctagag ttttaaacct cctaggaatt gttttaagaa tagtggcgac aatgcttacg 13441 gcagtataca gctttcgaat tatcttcttc tgcttctccc taagaccttc ttgtagctcc 13501 cctttctccc atagggaaga aaaatttaac ctcaaaaacg ccctattacg acttgccaca 13561 ggaacaatag caagcggatg atttttttca aaattgctat ttgctccccc ctcttttaat 13621 gttacctcgc tcgcaaaggg cacgccgctc atagtaccca taataggagt agctgccctc 13681 tttatgtcct taatatcatc gacctctaat tcaataggga gaaatgccca ctcagccaca 13741 acatcacagt gatttttcgt tgatgctgta cacctctcaa taatcactat gaggctcgcg 13801 ctctcctttt tctcctcccg aacgctagac cgaggatggc aagaaaaaat tggccctcaa 13861 ggaatagcac caacctcaac cgccctttct aagattagcc aagcagggca aatagggcta 13921 attaagcgat atatactctc ttcaatggcc tcagtattag taatactggc tctctctctt 13981 ttaatcttat cataaccaga tagcacgaat tattgttctt tcgattcctc gagaaattat 14041 caaagctcca actaaggcta caagcaacac aaaaacacct aagatgacca agacgccacc 14101 cctgttgtaa aaggtgtttc ttccgactag tctctcgcct ctaacaaaac aatgaaaaat 14161 attcttcagg tcttgaaaat tatcaaaaga cataaaaacc caggaagaaa aaagaaagac 14221 aagcccaaca acctccccta aattttttac tgagggaaac cgctcaggcg atatagcgct 14281 agagtaagga aacacgacta acattcctcc gatgtaaaca aggaacaata caatgggtac 14341 aaatgaccta cctaagaaag ataagacgaa ggacccagga accgaaaaaa ctaccaaccc 14401 taatgctgaa tagtatggcg agagactata aaaaactaaa gtccttccaa aaagcataac 14461 tataagtgtt acatatacta ccatttatta tatataagga ttaaaattat ggcagctcca 14521 ttacgaaagg aacatccaat tttccgaatt ctgaaaagta cattcgttga cctccccctt 14581 ccctccaacc tttccatttg gtgaaactcg ggctctctac tagggctgtg cttagttgtt 14641 caaatattga ctggaatatt cctagcaatg cactacacag ccgatattac cttagcattt 14701 tcatccgtta tgcacatttt gcgagatgta aattatggat gatttttacg atatgtacac 14761 gccaaaggcg tctctctctt ttttatctgt atgtactgcc acataggacg gggactatac 14821 tacgggtctt ataaaaagat tgagacctga aaagttggtg taatcctatt tttggttacc 14881 atcctaaccg cctttatggg ctatgtctta gtctgggggc aaatgtcctt ttgagctgcc 14941 acagtaatca caaatttagt gtctgcaatt ccctacatag gaactattat agttcagtga 15001 ttatgagggg gattctccgt cgacaaagcc acccttaccc gattttttcc ctttcacttc 15061 cttttcccct ttataatagc agccttagcg gttatacact tagtattcct ccacaacaga 15121 ggagccaaca acccttttgc cttcaaaagc aactatgaca aggccccttt ccacatttac 15181 ttcacgacca aggacacagt cgggtttatt cttttggtag ccgcactatt tagcttagcc 15241 ctcctatttc ctggcgccct aaaagaccca gagaaattca ttcctgcaaa cccactggtg 15301 actcccccac acattcagcc agaatggtac ttcttattcg cctacgccat tctgcgatct 15361 atccccaaca agttaggagg ggtaatcgcc ctagtagcag ccatactggt cttattcttg 15421 atgcccctcc taaacacctc gaagaaagag tctaactctt tccgaccgct atcacaagca 15481 gccttttggt tacttgttgc ccaccttttc atattaacat ggataggcag acaacccgta 15541 gagtacccat atgtgttact cggacaagtg gcctcagtac tttattttag gctatttata 15601 ttcgggttcc ccatagtttc ttcaatagaa aacaagatta tattttctta //