LOCUS EU153456 16456 bp DNA circular MAM 11-OCT-2007 DEFINITION Mammuthus primigenius isolate M4 mitochondrion, complete genome. ACCESSION EU153456 VERSION EU153456.1 GI:157367662 PROJECT GenomeProject:16317 KEYWORDS . SOURCE mitochondrion Mammuthus primigenius (woolly mammoth) ORGANISM Mammuthus primigenius Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Mammuthus. REFERENCE 1 (bases 1 to 16456) AUTHORS Gilbert,M.T., Tomsho,L.P., Rendulic,S., Packard,M., Drautz,D.I., Sher,A., Tikhonov,A., Dalen,L., Kuznetsova,T., Kosintsev,P., Campos,P.F., Higham,T., Collins,M.J., Wilson,A.S., Shidlovskiy,F., Buigues,B., Ericson,P.G., Germonpre,M., Gotherstrom,A., Iacumin,P., Nikolaev,V., Nowak-Kemp,M., Willerslev,E., Knight,J.R., Irzyk,G.P., Perbost,C.S., Fredrikson,K.M., Harkins,T.T., Sheridan,S., Miller,W. and Schuster,S.C. TITLE Whole-genome shotgun sequencing of mitochondria from ancient hair shafts JOURNAL Science 317 (5846), 1927-1930 (2007) PUBMED 17901335 REFERENCE 2 (bases 1 to 16456) AUTHORS Miller,W., Gilbert,M.T.P. and Schuster,S.C. TITLE Direct Submission JOURNAL Submitted (12-SEP-2007) Center for Comparative Genomics and Bioinformatics, Penn State University, 310 Wartik Building, University Park, PA 16802, USA FEATURES Location/Qualifiers source 1..16456 /organism="Mammuthus primigenius" /organelle="mitochondrion" /mol_type="genomic DNA" /isolate="M4" /db_xref="taxon:37349" tRNA 1..69 /product="tRNA-Phe" rRNA 72..1031 /product="12S ribosomal RNA" tRNA 1032..1099 /product="tRNA-Val" rRNA 1101..2666 /product="16S ribosomal RNA" tRNA 2667..2741 /product="tRNA-Leu" gene 2742..3698 /gene="ND1" CDS 2742..3698 /gene="ND1" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 1" /protein_id="ABV45760.1" /db_xref="GI:157367663" /translation="MFLINVLTVTLPILLAVAFLTLVERKALGYMQLRKGPNVVGPYG LLQPIADAIKLFTKEPVYPQTSSKFLFTVAPILALTLALTVWAPLPMPYPLINLNLSL LFILAMSSLMVYSILWSGWASNSKYALMGALRAVAQTISYEVSMTTIILSMVLMNGSF TLTAFATTQEHLWLIFPMWPLMMMWFTSTLAETNRAPFDLTEGESELVSGFNVEYSAG PFALFFMAEYANIIMMNALTVILFMGTSCNPQMPEISTINFVVKTIILTICFLWVRAS YPRFRYDQLMYLLWKNFLPLTLALCMWHISILISLACIPPQA" tRNA 3697..3765 /product="tRNA-Ile" tRNA complement(3763..3834) /product="tRNA-Gln" tRNA 3837..3906 /product="tRNA-Met" gene 3907..4950 /gene="ND2" CDS 3907..4950 /gene="ND2" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 2" /protein_id="ABV45761.1" /db_xref="GI:157367664" /translation="MNPLALSLILTTLLAGTLITMMSSHWLTAWMGLEMNMLTMIPIL MKTTNPRSTEAATKYFMTQATASMMLMMALTINLMYSGQWSIMKMTNPVASNVALMAL MTKLGSAPFHFWVPEVTQGVELTSGMILLTWQKLAPLSLLYQMATYTNTNLIYLSGLL SILIGGWGGLNQTQLRKILAYSSISHMGWMLIILPFNPTLTLLNLAIYILLTLSIFMI LANTLTTSMSSLTLMWNKTPAMTIMLMTTLLSLGGLPPLSGFTPKWLMIHELTKNNSI IMPLTMAIMTLLNMYFYMRLIYYSSLTILPSTNNMKMTWQFTNTKHTMMLPTLITLSN MLLPLTPMISMLE" tRNA 4949..5016 /product="tRNA-Trp" tRNA complement(5020..5088) /product="tRNA-Ala" tRNA complement(5089..5162) /product="tRNA-Asn" rep_origin 5163..5199 /direction=left tRNA complement(5200..5267) /product="tRNA-Cys" tRNA complement(5268..5331) /product="tRNA-Tyr" gene 5333..6880 /gene="COX1" CDS 5333..6880 /gene="COX1" /codon_start=1 /transl_table=2 /product="cytochrome c oxidase subunit I" /protein_id="ABV45762.1" /db_xref="GI:157367665" /translation="MFANRWLYSTNHKDIGTLYLLFGAWAGMVGTAFSILIRAELGQP GSLLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLIPLMIGAPDMAFPRMNNMSF WLLPPSFLLLLASSMVEAGTGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILS AINFITTIINMKPPAMSQYHMPLFVWSILVTAVLLLLSLPVLAAGITMLLTDRNLNTT FFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMVSHIVTYYSGKKEPFGYMGMVWA MMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKW SPAMMWALGFIFLFTIGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGG FIHWFPLFSGYTLNHTWAKIQFLVMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTAW NTASSMGSFISLVAVILMVFMIWEAFASKREVSVMELTTTNVEWLNGCPPPHHTFEEP AYVKSNS" tRNA complement(6876..6943) /product="tRNA-Ser" tRNA 6954..7022 /product="tRNA-Asp" gene 7023..7706 /gene="COX2" CDS 7023..7706 /gene="COX2" /codon_start=1 /transl_table=2 /product="cytochrome c oxidase subunit II" /protein_id="ABV45763.1" /db_xref="GI:157367666" /translation="MAYPLQLGFQDATSPVMEELLHFHDHTLMIIFLISSLVLYIIML MLTTKLVHTNMMNVQEMEMIWTILPAIILILIALPSLHTLYMMDEINNPLLTIKTMGH QWFWSYEYTDYEDLAFDSYMITTDSLKFGELRLLEVDNRMVLPTDLPVRVLVSSEDVL HSWAVPSLGLKTDAIPGRLNQVTLTSMRPGLFYGQCSEICGANHSFMPIVLELVPLKY FESWSASLA" tRNA 7709..7775 /product="tRNA-Lys" gene 7776..7976 /gene="ATP8" CDS 7776..7976 /gene="ATP8" /codon_start=1 /transl_table=2 /product="ATP synthase F0 subunit 8" /protein_id="ABV45764.1" /db_xref="GI:157367667" /translation="MERMDIIIWLLAVVIVLTTLMIFLHLKTLKIIRLLFPVSKELSK KSCVFPWKKKWTKNYPPSSMYP" gene 7937..8605 /gene="ATP6" CDS 7937..8605 /gene="ATP6" /codon_start=1 /transl_table=2 /product="ATP synthase F0 subunit 6" /protein_id="ABV45765.1" /db_xref="GI:157367668" /translation="MNEELSAFFDVPVGTMMLAIAFPAILLPTPNRLITNRWITIQQW LVKLIMKQLLSIHNTKGLSWSLMLITLTLFIGLTNLLGLLPYSFAPTAQLTVNLSMAI PLWTGTVILGFRYKTKISLAHLLPQGTPTFLIPMIIIIETISLLIRPVTLAVRLTANI TAGHLLIHLTGTAALTLLSIHSMTITVTFITVVVLTILELAVALIQAYVFALLISLYL HESA" gene 8605..9414 /gene="COX3" CDS 8605..9414 /gene="COX3" /codon_start=1 /transl_table=2 /product="cytochrome c oxidase subunit III" /protein_id="ABV45766.1" /db_xref="GI:157367669" /translation="MTHQTHAYHMVDPSPWPLTGALSALLMTSGLTMWFHYHSVILLF LGLMTNTLTMFQWWRDVVREGTFQGHHTPVVQEGLRYGMILFITSEVLFFTGFFWAFY HSSLAPTPELGSYWPPVGVYPLNPLEVPLLNTSVLLASGVTITWAHHSLMEGNRKNML QALLITILLGVYFTLLQMFEYYEASFTISDGIYGSTFFVTTGFHGLHVIIGSTFLLTC FIRQLKFHFTSNHHFGFEAAAWYWHFVDVVWLFLYLSIYWWGSYFFSINLV" tRNA 9389..9458 /product="tRNA-Gly" gene 9459..9815 /gene="ND3" CDS 9459..9815 /gene="ND3" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 3" /protein_id="ABV45767.1" /db_xref="GI:157367670" /translation="MNLMTTLLTNTMLTSLMVLIAFWLPQTYTYSEKTSPYECGFDPM GSARLPFSMKFFLVAITFLLFDLEIALLLPLPWAIQANNTNLTLLMSFMLIILLAIGL AYEWLQKGLEWTKYGT" tRNA 9806..9872 /product="tRNA-Arg" gene 9876..10172 /gene="ND4L" CDS 9876..10172 /gene="ND4L" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 4L" /protein_id="ABV45768.1" /db_xref="GI:157367671" /translation="MPYIYMNITLAFVISLIGTLMYRSHLMSSLLCLEGMMLSLFTLN ALLSLNMNFTLSTTVPLILLVFAACEAAVGLALLIMISNTYGLDYVQNLNLLQC" gene 10166..11533 /gene="ND4" CDS 10166..11533 /gene="ND4" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 4" /protein_id="ABV45769.1" /db_xref="GI:157367672" /translation="MLKTILPTIMLIPLAWLTSNNMVWINTTLYSFAISLTSLHLLHQ PLDNSLNLSPEFFLDSLSTPLLILTIWLLPLMLIASQSHLSSGSTFQKKSYITTIILL QVSLIMTFAATDLILLYIMFETTLIPTMIIITRWGNQLERLNAGSYFLFYTLVGSLPL LVTLMLIQNTLGSLNLMMLPYLAKSINNLWSTNMLWLTCIMAFMVKMPLYGLHLWLPK AHVEAPIAGSMVLAAILLKLGGYGMLRITILLDPLTTHMYYPFLMLSLWGMVMTSSIC LRQTDMKSLIAYSSVSHMALVIIAIMLQTPWSFMGALALMIAHGLTSSMLFCLANSNY ERIHSRTMILARGLQTLLPLMATWWLLASLINMAPPPTINLIGELLIITTSFSWSNLT IFPMGLNVLITTMYTLHMMTTTQRGKTSHHAKSIKPSFTRENTLMALHLLPLLLLSLN PNIIL" tRNA 11544..11612 /product="tRNA-His" tRNA 11613..11671 /product="tRNA-Ser" tRNA 11672..11741 /product="tRNA-Leu" gene 11742..13553 /gene="ND5" CDS 11742..13553 /gene="ND5" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 5" /protein_id="ABV45770.1" /db_xref="GI:157367673" /translation="MNPISTLTLASLIILTLPITTTLLQNNKTNCFLYITKTAVTYAF VISLIPTLLFVQSNQEAYISNWHWMTIHTLKLSLSFKLDFFSLTFMPIALFITWSIME FSLWYMHSDPHINRFFKYLLLFLITMLILVSANNLLQLFMGWEGVGIMSFLLISWWHG RTDANTAALQAMLYNRIGDMGFIMMMAWFIIHLNSWEFQQIFLTNPKNTTLPLLGLLL ASTGKSAQFGLHPWLPSAMEGPTPVSALLHSSTMVMAGVFTLIRFYPLMENNLTIQTS TLCLGAITTLFTAICALTQNDIKKIIALSTSSQLGLMMVTIGINQPHLAFTHMCTHAF FKAMLFLSSGSIIHNLNNEQDIRKMGGLYKTMPITSTAIIIGSLALTGMPFLTGFYSK DPIIETANMSYINTWALLVTLIAVSMTASYSTRIIFFALLGQPRYPTLTRINENNPHL VNPIKRLILGSIFMGFFISMNTIPHTTPQMTMPPHLKFMALAVTLLGFTVATELNNMT HNLMFKQPSRMYTFSTTLGYYPTTTHRILPYLSLTMSQNLATTIMDSIWLEKMIPKNL TTMQKTAASLVSNQKGLMKLYFLSFLLSITLGLLIAL" gene complement(13547..14074) /gene="ND6" CDS complement(13547..14074) /gene="ND6" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 6" /protein_id="ABV45771.1" /db_xref="GI:157367674" /translation="MMYIVFVMSVLYVVGFIGFSSKPSPVYGGMSLIVSGGLGCGIIM SSGGSFLGLVVFLVYLGGMMVVFGYTIAMATEEYPETWGSNVVVLSAFLVGLLMEIFM IVWLFSGEHELVGFYFGGLEDLVVLGEGSFGYVREDYSGGASLYSYGFWFLAMAGWML FVSIFIAIEVTRKRY" tRNA complement(14075..14143) /product="tRNA-Glu" gene 14153..15289 /gene="Cytb" CDS 14153..15289 /gene="Cytb" /codon_start=1 /transl_table=2 /product="cytochrome b" /protein_id="ABV45772.1" /db_xref="GI:157367675" /translation="MTHIRKSHPLLKILNKSFIDLPTPSNISTWWNFGSLLGACLITQ ILTGLFLAMHYTPDTMTAFSSMSHICRDVNYGWIIRQLHSNGASIFFLCLYTHIGRNI YYGSYLYSETWNTGIMLLLITMATAFMGYVLPWGQMSFWGATVITNLFSAIPYIGTDL VEWIWGGFSVDKATLNRFFALHFILPFTMIALAGVHLTFLHETGSNNPLGLTSDSDKI PFHPYYTIKDFLGLLILILFLLLLTLLSPDMLGDPDNYMPADPLNTPLHIKPEWYFLF AYAILRSVPNKLGGVLALLLSILILGIMPLLHTSKHRSMMLRPLSQVLFWTLATDLLM LTWIGSQPVEYPYIIIGQMASILYFSIILAFLPIAGMIENYLIK" tRNA 15289..15354 /product="tRNA-Thr" tRNA complement(15356..15423) /product="tRNA-Pro" D-loop 15428..16456 ORIGIN 1 gttaatgtag cttaaaacaa aagcaaggta ctgaaaatac ctagacgagt atatccaact 61 ccataaacaa caaaggtttg gtcccggcct tcttattggt tactaggaaa cttatacatg 121 caagtatccg cccgccagtg aatacgcctt ctaaatcatc actgatcaaa gagagctggc 181 atcaagcaca caccccaagt gtagctcatg acgtctcgcc tagccacacc cccacgggaa 241 acagcagtag taaatattta gcaattaaca aaagttagac taagttatcc taataaagga 301 ctggtcaatt tcgtgccagc aaccgcggcc atacgattag tccaaattaa taagcatacg 361 gcgtaaagcg tattagaaga attaagaaaa taaagttaaa tcttatacta gctgtttaaa 421 gctcaagata agacataaat agcctacgaa agtgacttta ataatcctaa acatacgata 481 gctagggtac aaactgagat tagatacctc actatgccta gccctaaact ttgatagcta 541 cctttacaaa gctatccgcc agagaactac tagccagagc ttaaaactta aaggacttgg 601 cggtgcttta tatccaccta ggggagcctg tctcgtaacc gatgaacccc gatacacctt 661 accgtcactt gctaattcag tccatatacc accatcttca gcaaacccct atagggcaca 721 aaagtgagct taatcataac ccatgaaaaa gttaggccga ggtgtcgcct acgtgacggt 781 caaagatggg ctacattttc tattatagaa tagacaaacg gataccactc tgaaatgggt 841 ggttgaaggc ggatttagta gtaaactaag aatagagagc ttaattgaac aaggccatga 901 agcgcgtaca caccgcccgt cactctcctc aagtacctcc acatcaaaca atcatattac 961 agatttaaac aaatacaaga ggagacaagt cgtaacaagg taagcgtact ggaaagtgtg 1021 cttgggtaac tcaaagtgta gcttaacaaa aagcatctgg cttacaccta gaagacctca 1081 ttcacaatga tcactttgaa ctaaatctag ccctaccaac cttacaccca actctcacac 1141 tacattaaat taaaacattc atttatcaaa aagtatagga gatagaaatt tcactaaggc 1201 gcaatagaga tagtaccgca agggaatgat gaaagataat ttaatagtaa aaaatagcaa 1261 ggattaaccc ctttaccttt tgcataatga attaactaga aaaatctgac aaagagaact 1321 acagccagaa accccgaaat cagacgagct atctgatagt aatccccagg atcaattcat 1381 ctatgtggca aaatagtgaa aaaacttaca gatagaggtg aaataccaat cgagcctgat 1441 gatagctggt tgtccagaaa tagaatttca gttctaccta aaacttacca caaaaacaaa 1501 ataattccaa tgtaagtttt agagatattc aaaaggggta cagctctttt gaccaaggat 1561 acaaccttga ttagcgagta aattcaccat taatttcata gttggcttgg aagcagccat 1621 caattaagaa agcgttaaag ctcaacaacc aaccaaacta aaaaaatccc aagaattaat 1681 taatgatctc ctaaacataa tactggacta atctatataa atagaagaaa taatgttagt 1741 ataagtaata agaagtattt ctccctgcat aagcttatat cagatcggat gcccactgat 1801 agttaacaat caaataatta aatacaaaaa taaaaccttt attacaccaa ttgttaaccc 1861 aacacaggca tgcttaaggg aaagattaaa agaaggaaaa ggaactcggc aaacataaac 1921 cccgcctgtt taccaaaaac atcacctcga gcattactag tattcgaggc actgcctgcc 1981 cagtgaccaa gtgttaaacg gccgcggtac tctgaccgtg caaaggtagc ataatcattt 2041 gttccttaat tagggacttg tatgaacggc cacacgaggg tttaactgtc tctttcctct 2101 aatcaatgaa attgaccttc tcgtgaagag gcgagaataa acatataaga cgagaagacc 2161 ctatggagct taaattaact aatttaattg ctatcctata aatctacaag atacaactaa 2221 acagcataat aaattaacaa ttttggttgg ggtgacctcg gagaagaaaa aaacctccga 2281 acgatattat aattcagact ttacaagtca agattcacta atcgcttatt gacccaatac 2341 ttgatcaacg gaacaagtta ccctagggat aacagcgcaa tcctactcta gagtccctat 2401 cgacagcagg gtttacgacc tcgatgttgg atcaggacat cctaatggtg cagccgctat 2461 taagggttcg tttgttcaac gattaaagtc ctacgtgatc tgagttcaga ccggagcaat 2521 ccaggtcggt ttctatctat agtttattta ttccagtacg aaaggacaga aaaaatgagg 2581 ccaatcttac caagacgcct tcagctaaat ttatgaataa atctcaatct agataagcta 2641 aaccacccaa tccaagaaca ggatttgtta agatagcaaa aattggttac tgcataaaac 2701 ttaagctttt acttacggag gttcaactcc tcttcttaac aatgttcttg attaatgtcc 2761 taacagtaac cttgcctatc cttctagcag tagccttcct caccttagtt gaacgaaagg 2821 ccttaggcta catacaactt cgtaaaggcc ccaatgtagt aggaccctac ggtcttcttc 2881 aacctatcgc agatgcaatc aagctattta ccaaagaacc cgtctatcca caaacctcct 2941 caaaattcct atttaccgtt gccccaattc tagccctaac cttagcccta actgtatgag 3001 ctcctcttcc aataccatat cccctaatta acttaaatct aagcctatta tttattctcg 3061 caatatcaag tctgatagtt tactccatcc tatgatcagg ctgagcatca aattcaaaat 3121 acgccctcat aggagcccta cgagcagtag cccaaaccat ctcctatgaa gtctctataa 3181 caactattat cttatcaata gtactaataa atgggtcctt tacactaacc gccttcgcta 3241 caacacaaga acatctatga ctaatctttc ctatatgacc cctaataata atatgattta 3301 catcaacttt agcagaaact aaccgagctc catttgattt aaccgaagga gaatcagaac 3361 tagtttctgg cttcaacgtc gaatattcag ctggcccttt cgccctattt tttatagccg 3421 aatacgctaa cattatcata ataaatgccc ttactgtaat tctatttata ggaacctctt 3481 gtaaccccca aataccagaa attagcacca tcaactttgt cgtaaaaact atcatcttaa 3541 ctatctgctt tttatgagta cgagcatctt acccacgatt ccgatacgac caactaatat 3601 atctcctctg aaaaaatttt cttccactaa ctctagccct atgcatgtga cacatctcaa 3661 tcttgatttc actagcatgc atcccaccac aagcatagaa atatgtctga caaaagaatt 3721 actttgatag agtaaattat agaggtctaa accctcttat ttctagaatt gcaggaatcg 3781 aacctaaact cgagaattca aaaatctcag tgctaccaat tacaccatat cctactagta 3841 aggtcagcta aattaagcta tcgggcccat accccgaaaa tgtcggatta cacccctccc 3901 atactaataa acccactagc ccttagccta atcctaacaa cactactcgc aggaacacta 3961 attactataa taagctccca ttgactaaca gcctgaatag gactagaaat gaacatactt 4021 actataattc ctattctaat aaagacaacc aatccacgat ccacagaagc cgccacgaaa 4081 tactttataa cccaagccac agcatccata atacttataa tagctttaac aattaatcta 4141 atatactcag gacaatgatc aattataaaa ataaccaacc ctgtagcatc aaatgtagca 4201 ttaatagctc taataaccaa actaggctca gccccattcc acttctgagt cccagaagta 4261 acgcaaggag tcgaactcac atcaggaatg atcttattaa cctgacaaaa attagcacca 4321 ttatctctat tatatcaaat agccacctac accaacacca acctaatcta tctttctggc 4381 ctactttcaa tcctaattgg aggatgagga ggcctaaacc aaacacaact acgaaaaatc 4441 ttagcctact cttcaatctc ccatataggc tgaatactca ttattttacc ctttaaccct 4501 acccttactc tcctgaactt agccatttac attttactaa cactatccat ctttataatc 4561 ctagcaaata ccctcacaac ttcaatatca tccctaactc taatatgaaa caaaacacct 4621 gcaataacca ttatacttat aactaccttg ctatccttag gaggactacc tccactttca 4681 ggattcacac ctaaatgact tataatccat gaactgacta aaaacaacag tattatcata 4741 ccactaacca tagccattat aacactacta aacatgtact tctacatacg actaatctac 4801 tactcatcac tcacaattct accatctaca aataatatga aaataacctg acaatttact 4861 aatactaaac acacaataat attaccgact ctaatcaccc tatctaacat actacttccc 4921 ctaaccccaa taatttcaat gctagaatag gaatttaggt taaaacagac caagagcctt 4981 caaagcccta agtaagtgca ttatacttaa ctcctgaaat aaggactgca agatatcacc 5041 ttacatcaac tgaatgcaaa tcagacgctt taactaaact aagcccttct agattggagg 5101 gcttcaatcc cacgaaaatc ttagttaaca actaaacacc ctagctaact ggcttcaatc 5161 tacttctccc gccttgaagg agggggaaaa aggcgggaga agccccggca gaattgaagc 5221 tgcttttttt cgaatttgca gttcgacatg tttacacttt caaggcctgg taaaaagaga 5281 ttactctctg tggttagatt tacagtctaa tacttactca gccattttac ctatgtttgc 5341 taaccgctga ctatattcaa caaaccacaa agacattggg acactgtatc tattatttgg 5401 tgcttgagct ggtatagtag ggactgcttt tagtatccta attcgggcag aactaggtca 5461 accaggctct cttcttggag acgaccaaat ctataatgtt attgtcacag cacacgcctt 5521 tgtaataatc ttctttatag ttatgccaat tataattgga ggctttggaa actgattaat 5581 tccacttata atcggagcac ctgatatagc ttttcctcga ataaacaata tgagtttttg 5641 actactacct ccatctttcc tactactctt ggcatcttcc atagtagaag ctgggacagg 5701 cactggttgg accgtatacc ctcccctggc aggaaaccta gcccatgcag gagcttctgt 5761 agatttaact attttttcac ttcaccttgc aggagtatcc tctattttaa gtgcaattaa 5821 ttttatcact accatcatta acataaaacc tccagctatg tctcaatatc acataccctt 5881 atttgtatgg tccattttag ttacagccgt ccttcttctt ctatccctcc cagttctagc 5941 agcaggtatt acaatattat taacggaccg caacctcaat actactttct ttgaccctgc 6001 aggaggagga gacccaattc tataccaaca cctattctgg ttttttggac accctgaagt 6061 ctatattcta attctcccag gatttggaat agtttctcat atcgttacgt actactcagg 6121 gaaaaaagaa cccttcggtt atataggaat agtatgggct ataatatcaa ttggcttcct 6181 agggttcatt gtatgagccc accatatatt cactgtaggc atagacgtcg acactcgagc 6241 ctactttaca tccgctacta taattattgc tattccaact ggcgtaaaag tctttagttg 6301 actagctacc cttcatggcg gtaatattaa atgatccccc gctataatat gagccctagg 6361 atttatcttc ttatttacaa ttggagggtt aactggcatt gttcttgcca attcttcact 6421 agacattgtc ctacatgata cctactacgt tgtagctcac tttcactacg ttctatctat 6481 aggtgcagtt ttcgccatta tgggtgggtt tatccactgg tttccactat tttcagggta 6541 cacattaaac catacatgag ccaaaattca atttctagtt atatttatcg gtgttaattt 6601 gacattcttt cctcaacact ttcttggact atctggtata ccacgtcgat attctgacta 6661 tccagatgcc tacactgcat gaaatactgc ttcttctata ggctcattta tctctttagt 6721 agccgtaatt ctaatggtct tcataatttg agaggcattt gcttctaagc gcgaagtttc 6781 tgtgatagaa ctcacaacaa caaacgtaga atgactcaac ggatgtccac ctccacatca 6841 tacattcgaa gaaccagcct acgtaaaatc taactcgaga agggaaggaa tcgaacctcc 6901 aacagttagt ttcaagccaa ctctataacc tttatgcctt ctccagcagg catgaaattt 6961 tagtaaaaca attacatagc cttgtcagag ctaaactaca ggtttaaatc ccgtaaattt 7021 ctatggccta tccgttacaa ctgggattcc aagatgccac atctcctgtt atagaagaac 7081 tccttcactt ccatgatcat accctaataa ttattttcct tattagctcc ttagtcttgt 7141 atattatcat acttatatta actactaagc tagtccacac aaatataata aacgtccaag 7201 agatagaaat aatctgaacc attcttccag ctattatcct tattttaatt gccctgccct 7261 ctctacacac tttatatata atagatgaaa ttaataaccc cctactaaca atcaaaacca 7321 taggacacca atgattctgg agctatgaat atactgatta cgaagattta gctttcgact 7381 catacataat cactactgat agcctaaaat ttggagaact tcgattacta gaagtagaca 7441 atcgaatggt actacctaca gatctcccag ttcgagtatt agtctcatca gaagatgtcc 7501 tccattcatg ggctgtccca tccttaggtc taaaaacaga tgcaattcca ggacgactta 7561 atcaagtaac tttaacatca atacgacctg gtttattcta tggtcaatgt tccgaaatct 7621 gtggggcaaa ccatagcttt ataccaattg tcctagaact agttccactt aagtactttg 7681 aaagctggtc agcatcacta gcataatcat taagaagcta taatagcact aaccttttaa 7741 gttagagtat gagaacatag aattctcctt aatgaatgga acgaatagat atcattatct 7801 gattactagc agtcgtaatt gttcttacga cactaataat cttccttcat cttaaaaccc 7861 taaagatcat tcgccttctt ttcccagttt ctaaagaact atccaaaaag tcatgtgttt 7921 tcccttgaaa gaagaagtga acgaagaact atccgccttc ttcgatgtac ccgtaggtac 7981 aataatacta gctattgcgt ttccagcaat tctacttcca actccaaatc gcctaattac 8041 caaccgttga attacaatcc aacaatgact agtcaaatta attataaaac aacttctgtc 8101 tattcataat acaaaaggac tgtcatgatc tctaatatta attactctaa ctttattcat 8161 tggtctaacc aatctactag gtctattacc ctattcattc gctcctacag cacaactaac 8221 cgtaaactta agcatagcaa tccccctatg gactggtaca gttatcctgg gcttccgata 8281 taaaactaaa atctcactag cccatcttct cccacaagga acacctacat tccttatccc 8341 tataattatt attatcgaaa ccattagtct cctcattcga ccagtcactc tagcggttcg 8401 actcaccgct aatatcacgg caggtcactt acttattcat ttaaccggaa ccgccgcact 8461 aactttacta tcaattcatt caataacaat tacagtaaca tttattactg tagttgtact 8521 tacgatcctg gaacttgccg tagcactaat tcaggcctac gtctttgccc tactaattag 8581 cctctaccta catgagagtg cttaatgact caccaaacac atgcctatca catagtagat 8641 ccaagtccct gacctcttac cggagcatta tctgccctac ttataacatc tggcctaact 8701 atatggttcc actaccactc tgtaattctc ctatttttag gattaataac taatacccta 8761 actatattcc aatgatgacg agatgtggtt cgagaaggaa ccttccaggg ccaccataca 8821 cctgtcgtgc aagaaggttt acgatatggt ataattttat ttatcacctc tgaggtacta 8881 ttctttacag gtttcttctg agccttttat cactctagcc tagcacctac ccctgagcta 8941 ggaagctatt gacctccagt aggtgtatac ccactaaatc cactagaagt accactccta 9001 aatacgtcag tcctcttagc ttcaggagtg actattacct gagctcatca cagtttaata 9061 gaaggaaatc gtaaaaatat actccaagcc ctccttatta ctattctctt aggagtctac 9121 ttcacacttc tccaaatgtt tgaatactat gaagcatcct ttacaatctc cgacggtatc 9181 tatggctcaa ctttctttgt aaccacagga ttccatggtc tacacgttat tattggctct 9241 acatttctcc taacctgctt tattcgccaa cttaaattcc attttacatc caaccatcac 9301 ttcggctttg aagcagctgc ttgatattga catttcgtag acgtagtatg actattcctc 9361 tatttatcca tttactgatg aggatcctat ttctttagta ttaacttagt ataactaact 9421 tccaattagt aggctttggc agactccaaa aagaaataat caaccttata actacactac 9481 taaccaatac tatactaaca tcacttatag ttctaattgc attttgacta cctcaaacat 9541 atacctattc agaaaagaca agtccatatg aatgcggctt tgatccaata ggttctgctc 9601 gcctaccatt ctcaataaaa ttctttttag tagccatcac gtttctccta tttgacctag 9661 aaatcgcatt actcctacct ttaccctgag ctatccaagc taataataca aatctgacac 9721 tcctgatatc attcatatta atcattctct tagctattgg cctagcctat gaatgactcc 9781 aaaaaggcct tgaatgaact aaatatggta cttagtttaa acaaaacaaa tgatttcgac 9841 tcattaaact atgaatacat cataattacc aaataatgcc ctacatttac ataaatatca 9901 cattagcctt cgttatttca ctcattggta ccctcatata ccgctctcac ctaatatctt 9961 cattactatg ccttgaagga ataatactat cactgtttac cttaaatgca ctattatccc 10021 tcaatataaa cttcacgttg tctactacag taccattaat tctactagta ttcgcagcct 10081 gtgaagccgc agtaggtttg gcacttctta ttataatctc caatacctac ggactagact 10141 acgtacaaaa cttaaaccta cttcagtgct aaaaactatt ctaccaacaa tcatacttat 10201 tccccttgcc tgactcacct ctaacaacat agtatgaatc aacaccaccc tttatagctt 10261 cgcaattagt ctaactagcc tccacctcct ccatcaaccc cttgacaata gcctaaacct 10321 ctccccagaa ttctttttag actctctatc taccccacta ttaatcctta ccatttgact 10381 acttccccta atactaatcg ctagccaatc ccatctatcc tccggatcaa cttttcagaa 10441 aaagtcctat atcactacaa tcatcctctt acaagtatcc ctaatcatga cattcgctgc 10501 tacagaccta atcctactat acattatatt tgaaacaaca cttatcccaa ctataatcat 10561 cattactcga tgaggaaacc aactggaacg gttaaacgca ggatcatact ttctattcta 10621 caccctagta ggatctctcc ccctactagt aaccctcata ctaatccaaa ataccctagg 10681 atcactaaac ctaataatac taccatacct agccaaatcc attaacaatt tatgatccac 10741 taatatacta tgactgacat gtattatagc tttcatagta aaaatacctc tatatggtct 10801 ccacctatga ctaccaaaag ctcatgtaga agcaccaatc gctggatcta tagtgttagc 10861 tgccattctc ttaaaactag gagggtatgg aatactacga atcaccatcc tcttagatcc 10921 cctaacaaca cacatatact acccattcct catactatca ctatgaggca tggtcataac 10981 cagttctatc tgcttgcgac aaacagatat gaagtccctc atcgcttatt cttcagtcag 11041 ccacatagcc ttagtaatca ttgctattat acttcaaaca ccatgaagtt ttataggggc 11101 acttgcccta ataatcgctc atggcctaac ttcctcaata cttttctgtc tagcaaattc 11161 aaactacgaa cgcattcata gccgaactat aattttagca cgaggcttac aaacccttct 11221 cccactaata gctacatgat gactactagc tagcttaatt aacatggctc caccacccac 11281 cattaatcta atcggagaat tactcattat cacaacatca ttttcatggt ccaatctcac 11341 cattttccct ataggactga acgtattaat tactacaata tacacccttc acataataac 11401 cacaactcaa cgaggaaaaa cgtcacacca cgctaaatcc attaaacctt catttacccg 11461 agagaacacc ttgatagctc ttcatcttct acccctacta ctcctttccc taaaccccaa 11521 tattatccta agatcaacat actgtagaca tagtttaacc aaaacattag gttgtgagcc 11581 tacaaataag aatttaatcc tctttgccta ccaagaaaga attaaggaac tgctaattcc 11641 ttatacctca tctaacaatg tggctttctt aacttttaaa gggtaagagc tacccattgg 11701 tcttaggcac caaaaaactg gtgcaactcc agataaaagt aatcaaccca atctcaaccc 11761 taacactagc atcactaatt attctaaccc tacctattac cacaacacta ctacaaaata 11821 acaagacaaa ctgcttttta tatatcacca aaacagctgt aacctacgcc ttcgtaatca 11881 gtctaatccc aactctatta tttgttcaat ctaaccaaga agcctatatc tctaactgac 11941 actgaataac aatccacacc ctaaagttat ctctaagctt taaactagac ttcttttccc 12001 taacattcat gccaattgca ctttttatta cctgatcaat catagaattt tcactatgat 12061 atatacactc agatccccat attaatcgct tcttcaaata cctcctgtta tttctaatca 12121 ctatactaat cctggtaagc gctaataacc tactacaact atttatgggc tgagagggag 12181 ttggcattat gtcctttctc ctaatcagtt gatggcacgg acgaacagac gctaacacag 12241 cggctctaca agcaatactt tataatcgta tcggtgatat aggcttcatt ataataatag 12301 cctgatttat tatccactta aattcctgag aattccaaca aatcttttta actaacccta 12361 aaaacactac actcccacta ctaggtcttc tcttagcctc aacaggaaaa tcagcccaat 12421 ttggacttca tccgtgactt ccatcagcta tagaaggccc taccccagta tcagcactcc 12481 ttcattccag tacaatagtt atagctggag tatttaccct catccgcttt tatccactaa 12541 tagaaaacaa cctcactatt caaacttcaa cactatgcct aggagccatt accactttat 12601 tcacagctat ctgtgctctt acacagaacg acatcaaaaa gattatcgca ctctccactt 12661 ccagccaact aggcctaatg atagtaacca tcggcattaa tcaaccacat ctagccttta 12721 cccacatatg tacacacgca ttcttcaagg caatactatt tctctcctct ggctctatca 12781 tccacaacct aaacaacgaa caagacatcc gcaaaatagg aggactctat aaaacaatac 12841 ccattacttc aacagctatc attattggca gcttagcact cactggcatg ccattcctaa 12901 cagggtttta ctcaaaagac ccaattattg aaactgctaa catatcctat atcaacacct 12961 gagcactact ggttactctc attgccgtat ccataacggc aagttacagt acccgaatca 13021 ttttctttgc tctccttgga caaccacgat accccacact aactcgaatc aacgagaata 13081 acccgcacct cgttaatcct attaaacgat taatcctagg cagcattttt ataggcttct 13141 tcatctcaat aaatactatt ccgcatacaa caccccaaat aaccatacct ccacatttaa 13201 aatttatagc cctagcagta accttactag gatttacagt agcaacagaa cttaataata 13261 taacacacaa tctaatattt aaacaaccat cacgtatata cacattctca accacattag 13321 ggtattaccc aactaccact catcgaatcc tgccctacct aagcctcact ataagccaaa 13381 atctagcaac aaccattata gactcaattt gactagaaaa aataatcccc aaaaacctaa 13441 caactataca aaaaacagcc gccagcctgg tatctaacca aaaaggccta ataaaactct 13501 actttttatc attccttcta tcaattacac taggtttact aatcgcccta taacgttttc 13561 gagtaacctc aatagcaata aaaatactaa caaacagtat tcacccagcc atagccaaaa 13621 atcaaaaccc atagctatac aaagacgctc ccccagaata atcctcacgt acatacccaa 13681 aactcccttc accaagaact acaagatctt ccagaccacc aaaataaaaa cccaccaatt 13741 cgtgctcacc actgaacaat catacaatta taaaaatctc cattaacaaa cctactaaaa 13801 atgcactcaa aactacaaca tttgaccctc aagtctcagg atactcctca gtagccatag 13861 caatagtata accaaaaacc actatcatcc cgcccaaata tactaaaaat acaactagac 13921 ccaagaaaga tcccccagaa ctcataataa tcccacatcc caagcctcca cttacaatca 13981 aactcatccc cccataaaca ggggaaggct tagacgaaaa accaatgaaa cctaccacat 14041 aaagcacact cataacaaaa acaatataca tcattacctc tacatggact cctaccatga 14101 ctaatgatct gaaaaaccat cgttgtattt caactataga aataactaaa taatgaccca 14161 cattcgaaaa tctcaccccc tacttaaaat ccttaataaa tccttcattg atctacctac 14221 cccatctaac atctcaacat gatgaaattt cggctcacta ctaggagcat gcctaattac 14281 ccaaatccta acagggttat ttctagccat acattataca cctgacacaa taactgcatt 14341 ttcatctata tcccatatct gccgagatgt caactacggt tgaattattc gacaactaca 14401 ctcaaacgga gcatctattt tcttcctctg cctatacaca cacattggac gaaacatcta 14461 ctatgggtcc tacctatact cggaaacctg aaataccggc attatactac tactaatcac 14521 catagccacc gccttcatag gatatgtcct tccgtgagga caaatatcat tctgaggggc 14581 aaccgtaatc actaacctct tctcagcaat tccctacatc ggcacagacc tagtagaatg 14641 aatctgagga ggcttttcgg tagataaagc aaccttaaat cgattcttcg ccctccattt 14701 tattcttcca tttactataa ttgcactagc aggagtacac ctaaccttcc ttcacgaaac 14761 aggctcaaat aacccactag gcctcacttc agactcagac aaaatcccct ttcacccgta 14821 ctataccatc aaagacttcc taggactact tatcctaatc ctattccttc tactcttaac 14881 cctactatct cctgacatac taggagaccc cgacaactac ataccagctg atccacttaa 14941 tactccccta cacatcaaac cagagtgata cttcctcttt gcttacgcca tcctacgatc 15001 tgtaccaaac aaactaggag gcgtcctagc cctactccta tcaatcctaa tcctaggaat 15061 tataccactt ctacatacat ctaaacaccg aagtatgata cttcgacctc ttagccaagt 15121 cctattctga actctagcaa cagatctact aatacttaca tgaattggca gtcaaccagt 15181 agaatatccc tacatcatta tcggccaaat agcctcaatt ctatatttct ccattatcct 15241 agctttcctg ccaattgcag gaatgatcga aaactacctc attaagtaac ccctatagta 15301 taagacatta caatggtctt gtaagccata aatgaaagcc attttctaag ggtattcagg 15361 gaagaggtcc atttaccccg ctatcaatac ccaaaactga aattcttctt aaactattcc 15421 ctgcaagcaa atcaacccgc tatgtacatc gtgcattaaa tgctcgtccc catacataat 15481 gatatataat actaactata cttaatctta catagaccat actatgtata atcgtgcatc 15541 acattattta ccccatgctt ataagcaagt actgtttaat caatgtgtca agtcatattc 15601 gtgtagattc acaagtcatg tttcagctca tggatattat tcacctacga taaaccatag 15661 tcttacatag cacattaaag ctcttgatcg tacatagcac attactgaga aatctctagt 15721 catcatgcat atcacctcca acggttgtat cttaactacc tacctccgag aaaccatcaa 15781 cccgcccatc ttcgtgtccc tcttctcgct ccgggcccat caattgtggg ggtttctata 15841 ctggatctat acctggcatc tggttcttac ttcaggacca tctcacctaa aatcgcccac 15901 tctttcctct taaataagac atctcgatgg attaatgact aatcagccca tgatcataac 15961 ataactgtgg tgtcatgcat ttggtatctt tttaattttg gggatgctgt gattcagcta 16021 tggccgtctg aggccctaac acagtcaagc aacttgtagc tgagcttgaa ttgagtatta 16081 agatctggca cggtatatat ggggtattat tcagtcaatg ctcggaggac ataaaatttt 16141 ttaaacctaa attcccagnn nnnaccacta tgtaactatc tcttcaaacc ccccttaccc 16201 cccttagtta cccttggctc aatttctata ggtatatttt tttatcctgt caaaccccaa 16261 aagcaggact atactataga tgaaatcaag agtataaacg ggaggcgtaa ctagttacat 16321 aggggtgaaa gcaaatcatt ttgccttcga tacttgggta ctacttaaaa aatttatttt 16381 cttttcaaga gccatgttcc tagatttgaa aaaaaaaccc cggagacgcg tttcttataa 16441 aattctaccc catctc //