LOCUS EF108344 16302 bp DNA circular ROD 27-FEB-2007 DEFINITION Mus musculus domesticus strain WSB/EiJ mitochondrion, complete genome. ACCESSION EF108344 VERSION EF108344.1 GI:118200809 KEYWORDS . SOURCE mitochondrion Mus musculus domesticus (western European house mouse) ORGANISM Mus musculus domesticus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus. REFERENCE 1 (bases 1 to 16302) AUTHORS Goios,A., Pereira,L., Bogue,M., Macaulay,V. and Amorim,A. TITLE mtDNA phylogeny and evolution of laboratory mouse strains JOURNAL Genome Res. 17 (3), 293-298 (2007) PUBMED 17284675 REFERENCE 2 (bases 1 to 16302) AUTHORS Goios,A., Pereira,L., Bogue,M., Macaulay,V. and Amorim,A. TITLE Direct Submission JOURNAL Submitted (08-NOV-2006) IPATIMUP (Instituto de Patologia e Imunologia Molecular da Universidade do Porto), R. Dr. Roberto Frias, s/n, Porto 4200-465, Portugal FEATURES Location/Qualifiers source 1..16302 /organism="Mus musculus domesticus" /organelle="mitochondrion" /mol_type="genomic DNA" /strain="WSB/EiJ" /sub_species="domesticus" /db_xref="taxon:10092" tRNA 1..68 /product="tRNA-Phe" /anticodon=(pos:33..35,aa:Phe) rRNA 70..1024 /product="12S ribosomal RNA" tRNA 1025..1093 /product="tRNA-Val" /anticodon=(pos:1057..1059,aa:Val) rRNA 1094..2675 /product="16S ribosomal RNA" tRNA 2676..2750 /product="tRNA-Leu" /note="codons recognized: UUR" /anticodon=(pos:2711..2713,aa:Leu) gene 2751..3707 /gene="ND1" CDS 2751..3707 /gene="ND1" /EC_number="1.6.5.3" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 1" /protein_id="ABK79275.1" /db_xref="GI:118200810" /translation="MFFINILTLLVPILIAMAFLTLVERKILGYMQLRKGPNIVGPYG ILQPFADAMKLFMKEPMRPLTTSMSLFIIAPTLSLTLALSLWVPLPMPHPLINLNLGI LFILATSSLSVYSILWSGWASNSKYSLFGALRAVAQTISYEVTMAIILLSVLLMNGSY SLQTLITTQEHMWLLLPAWPMAMMWFISTLAETNRAPFDLTEGESELVSGFNVEYAAG PFALFFMAEYTNIILMNALTTIIFLGPLYYINLPELYSTNFMMEALLLSSTFLWIRAS YPRFRYDQLMHLLWKNFLPLTLALCMWHISLPIFTAGVPPYM" tRNA 3706..3774 /product="tRNA-Ile" /anticodon=(pos:3735..3737,aa:Ile) tRNA complement(3772..3842) /product="tRNA-Gln" /anticodon=(pos:complement(3808..3810),aa:Gln) tRNA 3845..3913 /product="tRNA-Met" /anticodon=(pos:3875..3877,aa:Met) gene 3914..4951 /gene="ND2" CDS 3914..4951 /gene="ND2" /EC_number="1.6.5.3" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 2" /protein_id="ABK79276.1" /db_xref="GI:118200811" /translation="MNPITLAIIYFTIFLGPVITMSSTNLMLMWVGLEFSLLAIIPML INKKNPRSTEAATKYFVTQATASMIILLAIVLNYKQLGTWMFQQQTNGLILNMTLMAL SMKLGLAPFHFWLPEVTQGIPLHMGLILLTWQKIAPLSILIQIYPLLNSTIILMLAIT SIFMGAWGGLNQTQMRKIMAYSSIAHMGWMLAILPYNPSLTLLNLMIYIILTAPMFMA LMLNNSMTINSISLLWNKTPAMLTMISLMLLSLGGLPPLTGFLPKWIIITELMKNNCL IMATLMAMMALLNLFFYTRLIYSTSLTMFPTNNNSKMMTHQTKTKPNLMFSTLAIMST MTLPLAPQLIN" tRNA 4950..5016 /product="tRNA-Trp" /anticodon=(pos:4981..4983,aa:Trp) tRNA complement(5018..5086) /product="tRNA-Ala" /anticodon=(pos:complement(5054..5056),aa:Ala) tRNA complement(5089..5159) /product="tRNA-Asn" /anticodon=(pos:complement(5126..5128),aa:Asn) rep_origin 5160..5191 /note="L-strand origin of replication" /direction=right tRNA complement(5192..5257) /product="tRNA-Cys" /anticodon=(pos:complement(5227..5229),aa:Cys) tRNA complement(5260..5326) /product="tRNA-Tyr" /anticodon=(pos:complement(5296..5298),aa:Tyr) gene 5328..6872 /gene="COXI" CDS 5328..6872 /gene="COXI" /EC_number="1.9.3.1" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="cytochrome c oxidase subunit I" /protein_id="ABK79277.1" /db_xref="GI:118200812" /translation="MFINRWLFSTNHKDIGTLYLLFGAWAGMVGTALSILIRAELGQP GALLGDDQIYNVIVTAHAFVMIFFMVMPMMIGGFGNWLVPLMIGAPDMAFPRMNNMSF WLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILG AINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTT FFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGIISHVVTYYSGKKEPFGYMGMVWA MMSIGFLGFIVWAHHMFTVGLDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKW SPAMLWALGFIFLFTVGGLTGIVLSNSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMAG FVHWFPLFSGFTLDDTWAKAHFAIMFVGVNMTFFPQHFLGLSGMPRRYSDYPDAYTTW NTVSSMGSFISLTAVLIMIFMIWEAFASKREVMSVSYASTNLEWLHGCPPPYHTFEEP TYVKVK" tRNA complement(6870..6938) /product="tRNA-Ser" /note="codons recognized: UCN" /anticodon=(pos:complement(6906..6908),aa:Ser) tRNA 6942..7011 /product="tRNA-Asp" /anticodon=(pos:6973..6975,aa:Asp) gene 7013..7696 /gene="COXII" CDS 7013..7696 /gene="COXII" /EC_number="1.9.3.1" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="cytochrome c oxidase subunit II" /protein_id="ABK79278.1" /db_xref="GI:118200813" /translation="MAYPFQLGLQDATSPIMEELMNFHDHTLMIVFLISSLVLYIISL MLTTKLTHTSTMDAQEVETIWTILPAVILIMIALPSLRILYMMDEINNPVLTVKTMGH QWYWSYEYTDYQDLCFDSYMIPTNDLKPGELRLLEVDNRVVLPMELPIRMLISSEDVL HSWAVPSLGLKTDAIPGRLNQATVTSNRPGLFYGQCSEICGSNHSFMPIVLEMVPLKY FENWSASMI" tRNA 7700..7764 /product="tRNA-Lys" /anticodon=(pos:7726..7728,aa:Lys) gene 7766..7969 /gene="ATP8" CDS 7766..7969 /gene="ATP8" /EC_number="3.6.1.3" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="ATP synthase F0 subunit 8" /protein_id="ABK79279.1" /db_xref="GI:118200814" /translation="MPQLDTSTWFITIISSMITLFILFQLKVSSQTFPLAPSPKSLTT MKVKTPWELKWTKIYLPHSLPQQ" gene 7927..8607 /gene="ATP6" CDS 7927..8607 /gene="ATP6" /EC_number="3.6.1.3" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="ATP synthase F0 subunit 6" /protein_id="ABK79280.1" /db_xref="GI:118200815" /translation="MNENLFASFITPTMMGFPIVVAIIMFPSILFPSSKRLINNRLHS FQHWLVKLIIKQMMLIHTPKGRTWTLMIVSLIMFIGSTNLLGLLPHTFTPTTQLSMNL SMAIPLWAGAVITGFRHKLKSSLAHFLPQGTPISLIPMLIIIETISLFIQPMALAVRL TANITAGHLLMHLIGGATLVLMNISPPTATITFIILLLLTILEFAVALIQAYVFTLLV SLYLHDNT" gene 8607..9390 /gene="COXIII" CDS 8607..9390 /gene="COXIII" /EC_number="1.9.3.1" /function="oxidative phosphorylation" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:9390,aa:TERM) /transl_table=2 /product="cytochrome c oxidase subunit III" /protein_id="ABK79281.1" /db_xref="GI:118200816" /translation="MTHQTHAYHMVNPSPWPLTGAFSALLLTSGLVMWFHYNSITLLT LGLLTNILTMYQWWRDVIREGTYQGHHTPIVQKGLRYGMILFIVSEVFFFAGFFWAFY HSSLVPTHDLGGCWPPTGISPLNPLEVPLLNTSVLLASGVSITWAHHSLMEGKRNHMN QALLITIMLGLYFTILQASEYFETSFSISDGIYGSTFFMATGFHGLHVIIGSTFLIVC LLRQLKFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS" tRNA 9391..9458 /product="tRNA-Gly" /anticodon=(pos:9421..9423,aa:Gly) gene 9459..9806 /gene="ND3" CDS 9459..9806 /gene="ND3" /EC_number="1.6.5.3" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 3" /protein_id="ABK79282.1" /db_xref="GI:118200817" /translation="MNLYTVIFINILLSLTLILVAFWLPQMNLYSEKANPYECGFDPT SSARLPFSMKFFLVAITFLLFDLEIALLLPLPWAIQTIKTSTMMIMAFILVTILSLGL AYEWTQKGLEWTE" tRNA 9808..9878 /product="tRNA-Arg" /anticodon=(pos:9841..9843,aa:Arg) misc_feature 9821..9831 /note="polymorphic region" gene 9880..10176 /gene="ND4L" CDS 9880..10176 /gene="ND4L" /EC_number="1.6.5.3" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 4L" /protein_id="ABK79283.1" /db_xref="GI:118200818" /translation="MPSTFFNLTMAFSLSLLGTLMFRSHLMSTLLCLEGMMLSLFIMT SVTSLNSNSMSSMPIPITILVFAACEAAVGLALLVKVSNTYGTDYVQNLNLLQC" gene 10170..11547 /gene="ND4" CDS 10170..11547 /gene="ND4" /EC_number="1.6.5.3" /function="oxidative phosphorylation" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:11547,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 4" /protein_id="ABK79284.1" /db_xref="GI:118200819" /translation="MLKIILPSLMLLPLTWLSSPKKTWTNVTSYSFLISLTSLTLLWQ TDENYKNFSNMFSSDPLSTPLIILTAWLLPLMLMASQNHLKKDNNVLQKLYISMLISL QILLIMTFSATELIMFYILFEATLIPTLIIITRWGNQTERLNAGIYFLFYTLIGSIPL LIALILIQNHVGTLNLMILSFTTHTLDASWSNNLLWLACMMAFLIKMPLYGVHLWLPK AHVEAPIAGSMILAAILLKLGSYGMIRISIILDPLTKYMAYPFILLSLWGMIMTSSIC LRQTDLKSLIAYSSVSHMALVIASIMIQTPWSFMGATMLMIAHGLTSSLLFCLANSNY ERIHSRTMIMARGLQMVFPLMATWWLMASLANLALPPSINLMGELFITMSLFSWSNFT IILMGINIIITGMYSMYMIITTQRGKLTNHMINLQPSHTRELTLMALHMIPLILLTTS PKLITGLTM" tRNA 11548..11615 /product="tRNA-His" /anticodon=(pos:11578..11580,aa:His) tRNA 11616..11674 /product="tRNA-Ser" /note="codons recognized: AGY" /anticodon=(pos:11635..11637,aa:Ser) tRNA 11675..11745 /product="tRNA-Leu" /note="codons recognized: CUN" /anticodon=(pos:11706..11708,aa:Leu) gene 11745..13568 /gene="ND5" CDS 11745..13568 /gene="ND5" /EC_number="1.6.5.3" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 5" /protein_id="ABK79285.1" /db_xref="GI:118200820" /translation="MNIFTTSILLIFILLLSPILISMSNLIKHINFPLYTTTSIKFSF IISLLPLLMFFHNNMEYMITTWHWVTMNSMELKMSFKTDFFSILFTSVALFVTWSIMQ FSSWYMHSDPNINRFIKYLTLFLITMLILTSANNMFQLFIGWEGVGIMSFLLIGWWYG RTDANTAALQAILYNRIGDIGFILAMVWFSLNMNSWELQQIMFSNNNDNLIPLMGLLI AATGKSAQFGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFHPLTTNNNFILTT MLCLGALTTLFTAICALTQNDIKKIIAFSTSSQLGLMMVTLGMNQPHLAFLHICTHAF FKAMLFMCSGSIIHSLADEQDIRKMGNITKIMPFTSSCLVIGSLALTGTPFLTGFYSK DLIIEAINTCNTNAWALLITLIATSMTAMYSMRIIYFVTMTKPRFPPLISINENDPDL MNPIKRLAFGSIFAGFVISYNIPPTSIPVLTMPWFLKTTALIISVLGFLIALELNNLT MKLSMNKANPYSSFSTLLGFFPSIIHRITPMKSLNLSLKTSLTLLDLIWLEKTIPKST STLHTNMTTLTTNQKGLIKLYFMSFLINIILIIILYSINLE" gene complement(13555..14073) /gene="ND6" CDS complement(13555..14073) /gene="ND6" /EC_number="1.6.5.3" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 6" /protein_id="ABK79286.1" /db_xref="GI:118200821" /translation="MNNYIFVLSSLFLVGCLGLALKPSPIYGGLGLIVSGFVGCLMVL GFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPETWGSNWLILGFLVLGVIMEVFL ICVLNYYDEVGVINLDGLGDWLMYEVDDVGVMLEGGIGVAAMYSCATWMMVVAGWSLF AGIFIIIEITRD" tRNA complement(14074..14142) /product="tRNA-Glu" /anticodon=(pos:complement(14110..14112),aa:Glu) gene 14148..15291 /gene="CYTB" CDS 14148..15291 /gene="CYTB" /EC_number="1.10.2.2" /function="oxidative phosphorylation" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:15291,aa:TERM) /transl_table=2 /product="cytochrome b" /protein_id="ABK79287.1" /db_xref="GI:118200822" /translation="MTNMRKTHPLFKIINHSFIDLPAPSNISSWWNFGSLLGVCLMVQ IITGLFLAMHYTSDTMTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGL YYGSYTFMETWNIGVLLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTL VEWIWGGFSVDKATLTRFFAFHFILPFIIAALAIVHLLFLHETGSNNPTGLNSDADKI PFHPYYTIKDILGILIMFLILMTLVLFFPDMLGDPDNYMPANPLNTPPHIKPEWYFLF AYAILRSIPNKLGGVLALILSILILALMPFLHTSKQRSLMFRPITQILYWILVANLLI LTWIGGQPVEHPFIIIGQLASISYFSIILILMPISGIIEDKMLKLYP" tRNA 15292..15358 /product="tRNA-Thr" /anticodon=(pos:15322..15324,aa:Thr) tRNA complement(15359..15425) /product="tRNA-Pro" /anticodon=(pos:complement(15393..15395),aa:Pro) D-loop 15426..16302 misc_feature 15454..15512 /note="ETAS1; extended termination associated sequence 1" misc_feature 15518..15561 /note="ETAS2; extended termination associated sequence 2" misc_feature 16038..16061 /note="CSB1; conserved sequencing block 1" misc_feature 16092..16107 /note="CSB2; conserved sequencing block 2" misc_feature 16117..16134 /note="CSB3; conserved sequencing block 3" ORIGIN 1 gttaatgtag cttaataaca aagcaaagca ctgaaaatgc ttagatggat aattgtatcc 61 cataaacaca aaggtttggt cctggcctta taattaatta gaggtaaaat tacacatgca 121 aacctccata gaccggtgta aaatccctta aacatttact taaaatttaa ggagagggta 181 tcaagcacat taaaatagct taagacacct tgcctagcca cacccccacg ggactcagca 241 gtgataaata ttaagcaata aacgaaagtt tgactaagtt atacctctta gggttggtaa 301 atttcgtgcc agccaccgcg gtcatacgat taacccaaac taattatctt cggcgtaaaa 361 cgtgtcaact ataaataaat aaatagaatt aaaatccaac ttatatgtga aaattcattg 421 ttaggaccta aactcaataa cgaaagtaat tctagtcatt tataatacac gacagctaag 481 acccaaactg ggattagata ccccactatg cttagccata aacctaaata attaaattta 541 acaaaactat ttgccagaga actactagcc atagcttaaa actcaaagga cttggcggta 601 ctttatatcc atctagagga gcctgttcta taatcgataa accccgctct acctcaccat 661 ctcttgctaa ttcagcctat ataccgccat cttcagcaaa ccctaaaaag gtattaaagt 721 aagcaaaaga atcaaacata aaaacgttag gtcaaggtgt agccaatgaa atgggaagaa 781 atgggctaca ttttcttata aaagaacatt actataccct ttatgaaact aaaggactaa 841 ggaggattta gtagtaaatt aagaatagag agcttaattg aattgagcaa tgaagtacgc 901 acacaccgcc cgtcaccctc ctcaaattaa attaaactta acataattaa tttctagaca 961 tccgtttatg agaggagata agtcgtaaca aggtaagcat actggaaagt gtgcttggaa 1021 taatcatagt gtagcttaat attaaagcat ctggcctaca cccagaagat ttcatgacca 1081 atgaacactc tgaactaatc ctagccctag ccctacacaa atataattat actattatat 1141 aaatcaaaac atttatccta ctaaaagtat tggagaaaga aattcgtaca tctaggagct 1201 atagaactag taccgcaagg gaaagatgaa agactaatta aaagtaagaa caagcaaaga 1261 ttaaaccttg taccttttgc ataatgaact aactagaaaa cttctaacta aaagaattac 1321 agctagaaac cccgaaacca aacgagctac ctaaaaacaa ttttatgaat caactcgtct 1381 atgtggcaaa atagtgagaa gatttttagg tagaggtgaa aagcctaacg agcttggtga 1441 tagctggtta cccaaaaaat gaatttaagt tcaattttaa acttgctaaa aaaacaacaa 1501 aatcaaaaag taagtttaga ttatagccaa aagagggaca gctcttctgg aacggaaaaa 1561 acctttaata gtgaataatt aacaaaacag cttttaacca ttgtaggcct aaaagcagcc 1621 accaataaag aaagcgttca agctcaacat aaaatttcaa ttaattccat aatttacacc 1681 aacttcctaa acttaaaatt gggttaatct ataactttat agatgcaaca ctgttagtat 1741 gagtaacaag aattccaatt ctccaggcat acgcgtataa caactcggat aaccattgtt 1801 agttaatcag actataggca ataatcacac tataaataat ccacctataa cttctctgtt 1861 aacccaacac cggaatgcct aaaggaaaga tccaaaaaga taaaaggaac tcggcaaaca 1921 agaaccccgc ctgtttacca aaaacatcac ctctagcatt acaagtatta gaggcactgc 1981 ctgcccagtg actaaagttt aacggccgcg gtatcctgac cgtgcaaagg tagcataatc 2041 acttgttcct taattaggga ctagcatgaa cggctaaacg agggtccaac tgtctcttat 2101 ctttaatcag tgaaattgac ctttcagtga agaggctgaa atataataat aagacgagaa 2161 gaccctatgg agcttaaatt atataactta tctatttaat ttattaaacc taatggccca 2221 aaaactatag tataagtttg aaatttcggt tggggtgacc tcggagaata aaaaatcctc 2281 cgaatgatta taacctagac ttacaagtca aagtaaaatc aacatatctt attgacccaa 2341 atatattttg atcaacggac caagttaccc tagggataac agcgcaatcc tatttaagag 2401 ttcatatcga caattagggt ttacgacctc gatgttggat caggacatcc caatggtgta 2461 gaagctatta atggttcgtt tgttcaacga ttaaagtcct acgtgatctg agttcagacc 2521 ggagcaatcc aggtcggttt ctatctattt acgatttctc ccagtacgaa aggacaagag 2581 aaatagagcc accttacaaa taagcgctct caacttaatt tatgaataaa atctaaataa 2641 aatatatacg tacaccctct aacctagaga aggttattag ggtggcagag ccaggaaatt 2701 gcgtaagact taaaaccttg ttcccagagg ttcaaatcct ctccctaata gtgttcttta 2761 ttaatatcct aacactcctc gtccccattc taatcgccat agccttccta acattagtag 2821 aacgcaaaat cttagggtac atacaactac gaaaaggccc taacattgtt ggtccatacg 2881 gcattttaca accatttgca gacgccataa aattatttat aaaagaacca atacgccctt 2941 taacaacctc tatatcctta tttattattg cacctaccct atcactcaca ctagcattaa 3001 gtctatgagt tcccctacca ataccacacc cattaattaa tttaaaccta gggattttat 3061 ttattttagc aacatctagc ctatcagttt actccattct atgatcagga tgagcctcaa 3121 actccaaata ctcactattc ggagctttac gagccgtagc ccaaacaatt tcatatgaag 3181 taaccatagc tattatcctt ttatcagttc tattaataaa tggatcctac tctctacaaa 3241 cacttattac aacccaagaa cacatatgat tacttctgcc agcctgaccc atagccataa 3301 tatgatttat ctcaacccta gcagaaacaa accgggcccc cttcgacctg acagaaggag 3361 aatcagaatt agtatcaggg tttaacgtag aatacgcagc cggcccattc gcgttattct 3421 ttatagcaga gtacactaac attattctaa taaacgccct aacaactatt atcttcctag 3481 gacccctata ctatatcaat ttaccagaac tctactcaac taacttcata atagaagctc 3541 tactactatc atcaacattc ctatggatcc gagcatctta tccacgcttc cgttacgatc 3601 aacttataca tcttctatga aaaaactttc tacccctaac actagcatta tgtatgtgac 3661 atatttcttt accaattttt acagcgggag taccaccata catatagaaa tatgtctgat 3721 aaaagaatta ctttgataga gtaaattata gaggttcaag ccctcttatt tctaggacaa 3781 taggaattga acctacactt aagaattcaa aattctccgt gctacctaaa caccttatcc 3841 taatagtaag gtcagctaat taagctatcg ggcccatacc ccgaaaacgt tggtttaaat 3901 ccttcccgta ctaataaatc ctatcaccct tgccatcatc tacttcacaa tcttcttagg 3961 tcctgtaatc acaatatcca gcaccaacct aatactaata tgagtaggcc tggaattcag 4021 cctactagca attatcccca tactaatcaa caaaaaaaac ccacgatcaa ctgaagcagc 4081 aacaaaatac ttcgtcacac aagcaacagc ctcaataatt atcctcctgg ccatcgtact 4141 caactataaa caactaggaa catgaatatt tcaacaacaa acaaacggtc ttatccttaa 4201 cataacatta atagccctat ccataaaact aggcctcgcc ccattccact tctgattacc 4261 agaagtaact caagggatcc cactgcacat aggacttatt cttcttacat gacaaaaaat 4321 tgctccccta tcaattttaa ttcaaattta cccgctactc aactctacta tcattttaat 4381 actagcaatt acttctattt tcataggggc atgaggagga cttaaccaaa cacaaatacg 4441 aaaaattata gcctattcat caattgccca cataggatga atattagcaa ttcttcctta 4501 caacccatcc ctcactctac tcaacctcat aatctatatt attcttacag cccctatatt 4561 catagcactt atactaaata actctataac catcaactca atctcacttc tatgaaataa 4621 aactccagca atactaacta taatctcact gatattacta tccctaggag gccttccacc 4681 actaacagga ttcttaccaa aatgaattat catcacagaa cttataaaaa acaactgtct 4741 aattatagca acactcatag caataatagc tctactaaac ctattctttt atactcgcct 4801 aatttattcc acttcactaa caatatttcc aaccaacaat aactcaaaaa taataactca 4861 ccaaacaaaa actaaaccca acctaatatt ttccacccta gctatcataa gcacaataac 4921 cctaccccta gccccccaac taattaacta gaagtttagg atatactagt ccgcgagcct 4981 tcaaagccct aagaaaacac acaagtttaa cttctgataa ggactgtaag acttcatcct 5041 acatctattg aatgcaaatc aattgcttta attaagctaa gacctcaact agattggcag 5101 gaattaaacc tacgaaaatt tagttaacag ctaaataccc tattactggc ttcaatctac 5161 ttctaccgcc gaaaaaaaaa aatggcggta gaagtcttag tagagatttc tctacacctt 5221 cgaatttgca attcgacatg aatatcacct taagacctct ggtaaaaaga ggatttaaac 5281 ctctgtgttt agatttacag tctaatgctt actcagccat tttacctatg ttcattaatc 5341 gttgattatt ctcaaccaat cacaaagata tcggaaccct ctatctacta ttcggagcct 5401 gagcgggaat agtgggtact gcactaagta ttttaattcg agcagaatta ggtcaaccag 5461 gtgcactttt aggagatgac caaatttaca atgttatcgt aactgcccat gcttttgtta 5521 taattttctt catagtaata ccaataataa ttggaggctt tggaaactga cttgtcccac 5581 taataatcgg agccccagat atagcattcc cacgaataaa taatataagt ttttgactcc 5641 taccaccatc atttctcctt ctcctagcat catcaatagt agaagcagga gcaggaacag 5701 gatgaacagt ctacccacct ctagccggaa atctagccca tgcaggagca tcagtagacc 5761 taacaatttt ctcccttcat ttagctggag tgtcatctat tttaggtgca attaatttta 5821 ttaccactat tatcaacatg aaacccccag ccataacaca gtatcaaact ccactatttg 5881 tctgatccgt acttattaca gccgtactgc tcctattatc actaccagtg ctagccgcag 5941 gcattactat actactaaca gaccgcaacc taaacacaac tttctttgat cccgctggag 6001 gaggggaccc aattctctac cagcatctgt tctgattctt tgggcaccca gaagtttata 6061 ttcttatcct cccaggattt ggaattattt cacatgtagt tacttactac tccggaaaaa 6121 aagaaccttt cggctatata ggaatagtat gagcaataat gtctattggc tttctaggct 6181 ttattgtatg agcccaccac atattcacag taggattaga tgtagacaca cgagcttact 6241 ttacatcagc cactataatt atcgcaattc ctaccggtgt caaagtattt agctgacttg 6301 caaccctaca cggaggtaat attaaatgat ctccagctat actatgagcc ttaggcttta 6361 ttttcttatt tacagttggt ggtctaaccg gaattgtttt atccaactca tcccttgaca 6421 tcgtgcttca cgatacatac tatgtagtag cccatttcca ctatgttcta tcaatgggag 6481 cagtgtttgc tatcatagca ggatttgttc actgattccc attattttca ggcttcaccc 6541 tagatgacac atgagcaaaa gcccacttcg ccatcatatt cgtaggagta aacataacat 6601 tcttccctca acatttcctg ggcctttcag gaataccacg acgctactca gactacccag 6661 atgcttacac cacatgaaac actgtctctt ctataggatc atttatttca ctaacagctg 6721 ttctcatcat gatctttata atttgagagg cctttgcttc aaaacgagaa gtaatatcag 6781 tatcgtatgc ttcaacaaat ttagaatgac ttcatggctg ccctccacca tatcacacat 6841 tcgaggaacc aacctatgta aaagtaaaat aagaaaggaa ggaatcgaac cccctaaaat 6901 tggtttcaag ccaatctcat atcctatatg tctttctcaa taagatatta gtaaaatcaa 6961 ttacataact ttgtcaaagt taaattatag atcaataatc tatatatctt atatggccta 7021 cccattccaa cttggtctac aagacgccac atcccctatt atagaagagc taataaattt 7081 ccatgatcac acactaataa ttgttttcct aattagctcc ttagtcctct atatcatctc 7141 gctaatatta acaacaaaac taacacatac aagcacaata gatgcacaag aagttgaaac 7201 catttgaact attctaccag ctgtaatcct tatcataatt gctctcccct ctctacgcat 7261 tctatatata atagacgaaa tcaacaaccc cgtattaacc gttaaaacca tagggcacca 7321 atgatactga agctacgaat atactgacta tcaagaccta tgctttgatt catatataat 7381 cccaacaaac gacctaaaac ctggtgaact acgactgcta gaagttgata accgagtcgt 7441 tctgccaata gaacttccaa tccgtatatt aatttcatct gaagacgtcc tccactcatg 7501 agcagtcccc tccctaggac ttaaaactga tgccatccca ggccgactaa atcaagcaac 7561 agtaacatca aaccgaccag ggttattcta tggccaatgc tctgaaattt gtggatctaa 7621 ccatagcttt atgcccattg tcctagaaat ggttccacta aaatatttcg aaaactgatc 7681 tgcttcaata atttaatttc actatgaagc taagagcgtt aaccttttaa gttaaagtta 7741 gagaccttaa aatctccata gtgatatgcc acaactagat acatcaacat gatttatcac 7801 aattatctca tcaataatta ccctatttat cttatttcaa ctaaaagtct catcacaaac 7861 attcccactg gcaccttcac caaaatcact aacaaccata aaagtaaaaa ccccttgaga 7921 attaaaatga acgaaaatct atttgcctca ttcattaccc caacaataat aggattccca 7981 atcgttgtag ccatcattat atttccttca atcctattcc catcctcaaa acgcctaatc 8041 aacaaccgtc tccattcttt ccaacactga ctagttaaac ttattatcaa acaaataatg 8101 ctaatccaca caccaaaagg acgaacatga accctaataa ttgtttccct aatcatattt 8161 attggatcaa caaatctcct aggcctttta ccacatacat ttacacctac tacccaacta 8221 tccataaatc taagtatagc cattccacta tgagctggag ccgtaattac aggcttccga 8281 cacaaactaa aaagctcact tgcccacttc cttccacaag gaactccaat ttcactaatt 8341 ccaatactta ttattattga aacaattagc ctatttattc aaccaatggc attagcagtc 8401 cggcttacag ctaacattac tgcaggacac ttattaatac acctaatcgg aggagctact 8461 ctagtattaa taaatattag cccaccaaca gctaccatta catttattat tttacttcta 8521 ctcacaattc tagaatttgc agtagcatta attcaagcct acgtattcac cctcctagta 8581 agcctatatc tacatgataa tacataatga cccaccaaac tcatgcatat cacatagtta 8641 atccaagtcc atgaccatta actggagcct tttcagccct ccttctaaca tcaggtctag 8701 taatatgatt tcactataat tcaattacac tattaaccct tggcctactc accaatatcc 8761 tcacaatata tcaatgatga cgagacgtaa ttcgtgaagg aacctaccaa ggccaccaca 8821 ctcctattgt acaaaaagga ctacgatatg gtataattct attcatcgtc tcggaagtat 8881 ttttctttgc aggattcttc tgagcgttct atcattctag cctcgtacca acacatgatc 8941 taggaggctg ctgacctcca acaggaattt caccacttaa ccctctagaa gtcccactac 9001 ttaatacttc agtacttcta gcatcaggtg tttcaattac atgagctcat catagcctta 9061 tagaaggtaa acgaaaccac ataaatcaag ccctactaat taccattata ctaggacttt 9121 acttcaccat cctccaagct tcagaatact ttgaaacatc attctccatt tcagatggta 9181 tctatggttc tacattcttc atggctactg gattccatgg actccatgta attattggat 9241 caacattcct tattgtttgc ctactacgac aactaaaatt tcacttcaca tcaaaacatc 9301 acttcggatt tgaagccgca gcatgatact gacattttgt agacgtagtc tgacttttcc 9361 tatacgtctc catttattga tgaggatctt actcccttag tataattaat ataactgact 9421 tccaattagt agactctgaa taaacccaga agagagtaat caacctgtac actgttatct 9481 tcattaatat tttattatcc ctaacgctaa ttctagttgc attctgactc ccccaaataa 9541 atctgtactc agaaaaagca aatccatatg aatgcggatt cgaccctaca agctctgcac 9601 gtctaccatt ctcaataaaa tttttcttgg tagcaattac atttctatta tttgacctag 9661 aaattgctct tctacttcca ctaccatgag caattcaaac aattaaaacc tctactataa 9721 taattatagc ctttattcta gtcacaattc tatctctagg cctagcatat gaatgaacac 9781 aaaaaggatt agaatgaaca gagtaaatgg taattagttt aaaaaaaaaa attaatgatt 9841 tcgactcatt agattatgat gatgttcata attaccaata tgccatctac cttcttcaac 9901 ctcaccatag ccttctcact atcacttcta gggacactta tatttcgctc tcacctaata 9961 tccacattac tatgcctgga aggcataata ttatccttat ttattataac ttcagtaact 10021 tccctaaact ccaactccat aagctccata ccaatcccca tcaccatctt agttttcgca 10081 gcctgcgaag cagctgtagg actagcccta ctagtaaaag tttcaaacac gtacggaaca 10141 gattacgtcc aaaatctcaa cctactacaa tgctaaaaat tattcttccc tcactaatgc 10201 tactaccact aacctgacta tcaagcccta aaaaaacctg aacaaacgta acctcatata 10261 gttttctaat tagtttaacc agcctaacac ttctatgaca aaccgacgaa aattataaaa 10321 acttttcaaa tatattctcc tcagaccccc tatccacacc attaattatt ttaacagcct 10381 gattactgcc actaatatta atagctagcc aaaaccacct aaaaaaagat aataacgtac 10441 tacaaaaact ctacatctca atactaatca gcttacaaat tctcctaatc ataacctttt 10501 cagcaactga actaattata ttttatattt tatttgaagc aaccttaatc ccaacactta 10561 ttattattac ccgatgaggg aaccaaactg aacgcctaaa cgcagggatt tatttcctat 10621 tttataccct aatcggttct attccactgc taattgccct catcttaatc caaaaccatg 10681 taggaaccct aaacctcata attttatcat tcacaacaca caccttagac gcttcatgat 10741 ctaacaactt actatggttg gcatgcataa tagcatttct tattaaaata ccattatatg 10801 gagttcacct atgactacca aaagcccatg ttgaagctcc aattgctggg tcaataattc 10861 tagcagctat tcttctaaaa ttaggtagtt acggaataat tcgcatctcc attattctag 10921 acccactaac aaaatatata gcatacccct tcatccttct ctccctatga ggaataatta 10981 taactagctc aatctgctta cgccaaacag atttaaaatc actaatcgcc tactcctcag 11041 ttagccacat agcacttgtt attgcatcaa tcataatcca aactccatga agcttcatag 11101 gagcaacaat actaataatc gcacatggcc tcacatcatc actcctattc tgcctagcaa 11161 actccaacta cgaacggatc cacagccgta ctataatcat ggcccgagga cttcaaatgg 11221 tcttcccact tatagccaca tgatgactga tagcaagtct agctaatcta gctctacccc 11281 cttcaatcaa tctaatagga gaattattca ttaccatatc attattttct tgatcaaact 11341 ttaccattat tcttatagga attaacatta ttattacagg tatatactca atatacataa 11401 ttattaccac ccaacgcggc aaactaacca accatataat taacctccaa ccctcacaca 11461 cacgagaact aacactaata gcccttcaca taattccact tattcttcta actaccagtc 11521 caaaactaat tacaggcctg acaatatgtg aatatagttt acaaaaaaca ttagactgtg 11581 aatctgacaa caggaaataa acctccttat tcaccaagaa agattgcaag aactgctaat 11641 tcatgcttcc atgtttaaaa acatggcttt cttactttta taggataata gtaatccatt 11701 ggtcttagga accaaaaacc ttggtgcaaa tccaaataaa agtaatcaat attttcacaa 11761 cctcaatctt attaatcttc attcttctac tatccccaat cctaatttca atatcaaacc 11821 taattaaaca catcaacttc ccactgtaca ccaccacatc aatcaaattc tccttcatta 11881 ttagcctctt acccctatta atatttttcc acaataatat agaatatata attacaacct 11941 ggcactgagt caccataaat tcaatagaac ttaaaataag cttcaaaact gactttttct 12001 ctatcctgtt tacatctgta gccctttttg tcacatgatc aattatacaa ttctcttcat 12061 gatatataca ctcagaccca aacatcaatc gattcattaa atatcttaca ctattcctga 12121 ttaccatgct tatcctcacc tcagccaaca acatatttca acttttcatt ggctgagaag 12181 gggtgggaat tatatctttc ctactaattg gatgatggta cggacgaaca gacgcaaata 12241 ctgcagccct acaagcaatc ctctataacc gcatcggaga catcggattc attttagcta 12301 tagtttgatt ttccctaaac ataaactcat gagaacttca acagattata ttctccaaca 12361 acaacgacaa tctaattcca cttataggcc tattaatcgc agctacagga aaatcagcac 12421 aatttggcct ccacccatga ctaccatcag caatagaagg ccctacacca gtttcagcac 12481 tactacactc aagtacaata gtagttgcag gaattttcct actgatccga ttccaccccc 12541 tcacgactaa taataacttt attttaacaa ctatactttg cctcggagcc ctaaccacat 12601 tatttacagc tatttgtgct ctcacccaaa acgacatcaa aaaaatcatt gccttctcta 12661 catcaagcca actaggcctg ataatagtga cgctaggaat aaaccaacca cacctagcat 12721 tcctacacat ctgtacccac gcattcttca aagctatact ctttatatgc tctggctcaa 12781 tcattcatag cctggcagac gaacaagaca tccgaaaaat aggaaacatc acaaaaatca 12841 taccattcac atcatcatgc ctagtaatcg gaagcctcgc cctcacagga acaccattcc 12901 taacagggtt ctactcaaaa gacctaatta ttgaagcaat taatacctgc aacaccaacg 12961 cctgagccct actaattaca ctaatcgcca cttctataac agctatgtac agcatacgaa 13021 tcatttactt cgtaacaata acaaaaccgc gttttccccc cctaatctcc attaacgaaa 13081 atgacccaga cctcataaac ccaatcaaac gcctagcatt cggaagcatc tttgcaggat 13141 ttgtcatctc atataatatt ccaccaacca gcattccagt cctcacaata ccatgatttt 13201 taaaaaccac agccctaatt atttcagtat taggattcct aatcgcacta gaactaaaca 13261 acctaaccat aaaactatca ataaataaag caaatccata ttcatccttc tcaactttac 13321 tggggttttt cccatctatt attcaccgca ttacacccat aaaatctctc aacctaagcc 13381 taaaaacatc cctaactctc ctagacttga tctggttaga aaaaaccatc ccaaaatcca 13441 cctcaactct tcacacaaac ataaccactt taacaaccaa ccaaaaaggc ttaattaaat 13501 tgtactttat atcattccta attaacatca tcttaattat tatcttatac tcaattaatc 13561 tcgagtaatc tcgataataa taaaaatacc cgcaaacaaa gatcacccag ctactaccat 13621 cattcaagta gcacaactat atattgccgc taccccaatc cctccttcca acataactcc 13681 aacatcatca acctcataca tcaaccaatc tcccaaacca tcaagattaa ttactccaac 13741 ttcatcataa taattaagca cacaaattaa aaaaacctct ataatcaccc ccaatactaa 13801 aaaacccaaa attaatcagt tagatcccca agtctctgga tactcctcag tagctatagc 13861 agtcgtatat ccaaacacaa ccaacatccc ccctaaataa attaaaaaaa ctattaaacc 13921 taaaaacgat ccaccaaacc ctaaaaccat taaacaacca acaaacccac taacaattaa 13981 acctaaacct ccataaatag gtgaaggctt taatgctaac ccaagacaac caaccaaaaa 14041 taatgaactt aaaacaaaaa tataattatt cattatttct acacagcatt caactgcgac 14101 caatgacatg aaaaatcatc gttgtaattc aactacagaa acacctaatg acaaacatac 14161 gaaaaacaca cccattattt aaaattatta accactcatt cattgaccta cctgccccat 14221 ccaacatttc atcatgatga aactttgggt cccttctagg agtctgccta atagtccaaa 14281 tcattacagg tcttttctta gccatacact acacatcaga tacaataaca gccttttcat 14341 cagtaacaca catttgtcga gacgtaaatt acgggtgact aatccgatat atacacgcaa 14401 acggagcctc aatatttttt atttgcttat tccttcatgt cggacgaggc ttatattatg 14461 gatcatatac atttatagaa acctgaaaca ttggagtact tctactgttc gcagtcatag 14521 ccacagcatt tataggctac gtccttccat gaggacaaat atcattctga ggtgccacag 14581 ttattacaaa cctcctatca gccatcccat atattggaac aaccctagtc gaatgaattt 14641 gagggggctt ctcagtagac aaagccacct tgacccgatt cttcgctttc cacttcatct 14701 taccatttat tatcgcggcc ctagcaatcg ttcacctcct cttcctccac gaaacaggat 14761 caaacaaccc aacaggatta aactcagatg cagataaaat tccatttcac ccctactata 14821 caatcaaaga tatcctaggt atcctaatca tattcttaat tctcataacc ctagtattat 14881 ttttcccaga catactagga gacccagaca actacatacc agctaatcca ctaaacaccc 14941 caccccatat taaacccgaa tgatatttcc tatttgcata cgccattcta cgctcaatcc 15001 ccaataaact aggaggtgtc ctagccttaa tcttatctat cctaatttta gccctaatac 15061 ctttccttca tacctcaaag caacgaagcc taatattccg cccaatcaca caaattttgt 15121 actgaatcct agtagccaac ctacttatct taacctgaat tgggggccaa ccagtagaac 15181 acccatttat tatcattggc caactagcct ccatctcata cttctcaatc atcttaattc 15241 ttataccaat ctcaggaatt atcgaagaca aaatactaaa attatatcca tgtcttgata 15301 gtataaacat tactctggtc ttgtaaacct gaaatgaaga tcttctcttc tcaagacatc 15361 aagaagaagg agctactccc caccaccagc acccaaagct ggtattctaa ttaaactact 15421 tcttgagtac ataaatttac atagtacaac agtacattta tgtatatcgt acattaaact 15481 attttcccca agcatataag ctagtacatt aaatcaatgg ttcaggtcat aaaataatca 15541 tcaacataaa tcaatatata taccatgaat attatcttaa acacattaaa ctaatgttat 15601 aaggacatat ctgtgttatc tgacatacac catacagtca taaactcttc tcttccatat 15661 gactatcccc ttccccattt ggtctattaa tctaccatcc tccgtgaaac caacaacccg 15721 cccaccaatg cccctcttct cgctccgggc ccattaaact tgggggtagc taaactgaaa 15781 ctttatcaga catctggttc ttacttcagg gccatcaaat gcgttatcgc ccatacgttc 15841 cccttaaata agacatctcg atggtatcgg gtctaatcag cccatgacca acataactgt 15901 ggtgtcatgc atttggtatc tttttatttt ggcctacttt catcaacata gccgtcaagg 15961 catgaaagga cagcacacag tctagacgca cctacggtga agaatcatta gtccgcaaaa 16021 cccaatcacc taaggctaat tattcatgct tgttagacat aaatgctact caataccaaa 16081 ttttaactct ccaaaccccc caccccctcc tcttaatgcc aaaccccaaa aacactaaga 16141 acttgaaaga catataatat taactatcaa accctatgtc ctgatcaatt ctagtagttc 16201 ccaaaatatg acttatattt tagtacttgt aaaaatttta caaaatcatg ttccatgaac 16261 caaaactcta atcatactct attacgcaat aaacattaac aa //