LOCUS EF108332 16300 bp DNA circular ROD 27-FEB-2007 DEFINITION Mus musculus strain AKR/J mitochondrion, complete genome. ACCESSION EF108332 VERSION EF108332.1 GI:118200641 KEYWORDS . SOURCE mitochondrion Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus. REFERENCE 1 (bases 1 to 16300) AUTHORS Goios,A., Pereira,L., Bogue,M., Macaulay,V. and Amorim,A. TITLE mtDNA phylogeny and evolution of laboratory mouse strains JOURNAL Genome Res. 17 (3), 293-298 (2007) PUBMED 17284675 REFERENCE 2 (bases 1 to 16300) AUTHORS Goios,A., Pereira,L., Bogue,M., Macaulay,V. and Amorim,A. TITLE Direct Submission JOURNAL Submitted (08-NOV-2006) IPATIMUP (Instituto de Patologia e Imunologia Molecular da Universidade do Porto), R. Dr. Roberto Frias, s/n, Porto 4200-465, Portugal FEATURES Location/Qualifiers source 1..16300 /organism="Mus musculus" /organelle="mitochondrion" /mol_type="genomic DNA" /strain="AKR/J" /db_xref="taxon:10090" tRNA 1..68 /product="tRNA-Phe" /anticodon=(pos:33..35,aa:Phe) rRNA 70..1024 /product="12S ribosomal RNA" tRNA 1025..1093 /product="tRNA-Val" /anticodon=(pos:1057..1059,aa:Val) rRNA 1094..2675 /product="16S ribosomal RNA" tRNA 2676..2750 /product="tRNA-Leu" /note="codons recognized: UUR" gene 2751..3707 /gene="ND1" CDS 2751..3707 /gene="ND1" /EC_number="1.6.5.3" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 1" /protein_id="ABK79119.1" /db_xref="GI:118200642" /translation="MFFINILTLLVPILIAMAFLTLVERKILGYMQLRKGPNIVGPYG ILQPFADAMKLFMKEPMRPLTTSMSLFIIAPTLSLTLALSLWVPLPMPHPLINLNLGI LFILATSSLSVYSILWSGWASNSKYSLFGALRAVAQTISYEVTMAIILLSVLLMNGSY SLQTLITTQEHMWLLLPAWPMAMMWFISTLAETNRAPFDLTEGESELVSGFNVEYAAG PFALFFMAEYTNIILMNALTTIIFLGPLYYINLPELYSTNFMMEALLLSSTFLWIRAS YPRFRYDQLMHLLWKNFLPLTLALCMWHISLPIFTAGVPPYM" tRNA 3706..3774 /product="tRNA-Ile" /anticodon=(pos:3735..3737,aa:Ile) tRNA complement(3772..3842) /product="tRNA-Gln" /anticodon=(pos:complement(3808..3810),aa:Gln) tRNA 3845..3913 /product="tRNA-Met" /anticodon=(pos:3875..3877,aa:Met) gene 3914..4951 /gene="ND2" CDS 3914..4951 /gene="ND2" /EC_number="1.6.5.3" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 2" /protein_id="ABK79120.1" /db_xref="GI:118200643" /translation="MNPITLAIIYFTIFLGPVITMSSTNLMLMWVGLEFSLLAIIPML INKKNPRSTEAATKYFVTQATASMIILLAIVLNYKQLGTWMFQQQTNGLILNMTLMAL SMKLGLAPFHFWLPEVTQGIPLHMGLILLTWQKIAPLSILIQIYPLLNSTIILMLAIT SIFMGAWGGLNQTQMRKIMAYSSIAHMGWMLAILPYNPSLTLLNLMIYIILTAPMFMA LMLNNSMTINSISLLWNKTPAMLTMISLMLLSLGGLPPLTGFLPKWIIITELMKNNCL IMATLMAMMALLNLFFYTRLIYSTSLTMFPTNNNSKMMTHQTKTKPNLMFSTLAIMST MTLPLAPQLIT" tRNA 4950..5016 /product="tRNA-Trp" /anticodon=(pos:4981..4983,aa:Trp) tRNA complement(5018..5086) /product="tRNA-Ala" /anticodon=(pos:complement(5054..5056),aa:Ala) tRNA 5089..5159 /product="tRNA-Asn" /anticodon=(pos:complement(5126..5128),aa:Asn) rep_origin 5160..5191 /note="L-strand origin of replication" /direction=right tRNA complement(5192..5257) /product="tRNA-Cys" /anticodon=(pos:complement(5227..5229),aa:Cys) tRNA complement(5260..5326) /product="tRNA-Tyr" /anticodon=(pos:complement(5296..5298),aa:Tyr) gene 5328..6872 /gene="COXI" CDS 5328..6872 /gene="COXI" /EC_number="1.9.3.1" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="cytochrome c oxidase subunit I" /protein_id="ABK79121.1" /db_xref="GI:118200644" /translation="MFINRWLFSTNHKDIGTLYLLFGAWAGMVGTALSILIRAELGQP GALLGDDQIYNVIVTAHAFVMIFFMVMPMMIGGFGNWLVPLMIGAPDMAFPRMNNMSF WLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILG AINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTT FFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGIISHVVTYYSGKKEPFGYMGMVWA MMSIGFLGFIVWAHHMFTVGLDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKW SPAMLWALGFIFLFTVGGLTGIVLSNSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMAG FVHWFPLFSGFTLDDTWAKAHFAIMFVGVNMTFFPQHFLGLSGMPRRYSDYPDAYTTW NTVSSMGSFISLTAVLIMIFMIWEAFASKREVMSVSYASTNLEWLHGCPPPYHTFEEP TYVKVK" tRNA complement(6870..6938) /product="tRNA-Ser" /note="codons recognized: UCN" /anticodon=(pos:complement(6906..6908),aa:Ser) tRNA 6942..7011 /product="tRNA-Asp" /anticodon=(pos:6973..6975,aa:Asp) gene 7013..7696 /gene="COXII" CDS 7013..7696 /gene="COXII" /EC_number="1.9.3.1" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="cytochrome c oxidase subunit II" /protein_id="ABK79122.1" /db_xref="GI:118200645" /translation="MAYPFQLGLQDATSPIMEELMNFHDHTLMIVFLISSLVLYIISL MLTTKLTHTSTMDAQEVETIWTILPAVILIMIALPSLRILYMMDEINNPVLTVKTMGH QWYWSYEYTDYEDLCFDSYMIPTNDLKPGELRLLEVDNRVVLPMELPIRMLISSEDVL HSWAVPSLGLKTDAIPGRLNQATVTSNRPGLFYGQCSEICGSNHSFMPIVLEMVPLKY FENWSASMI" tRNA 7700..7764 /product="tRNA-Lys" /anticodon=(pos:7726..7728,aa:Lys) gene 7766..7969 /gene="ATP8" CDS 7766..7969 /gene="ATP8" /EC_number="3.6.1.3" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="ATP synthase F0 subunit 8" /protein_id="ABK79123.1" /db_xref="GI:118200646" /translation="MPQLDTSTWFITIISSMITLFILFQLKVSSQTFPLAPSPKSLTT MKVKTPWELKWTKIYLPHSLPQQ" gene 7927..8607 /gene="ATP6" CDS 7927..8607 /gene="ATP6" /EC_number="3.6.1.3" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="ATP synthase F0 subunit 6" /protein_id="ABK79124.1" /db_xref="GI:118200647" /translation="MNENLFASFITPTMMGFPIVVAIIMFPSILFPSSKRLINNRLHS FQHWLVKLIIKQMMLIHTPKGRTWTLMIVSLIMFIGSTNLLGLLPHTFTPTTQLSMNL SMAIPLWAGAVITGFRHKLKSSLAHFLPQGTPISLIPMLIIIETISLFIQPMALAVRL TANITAGHLLMHLIGGATLVLMNISPPTATITFIILLLLTILEFAVALIQAYVFTLLV SLYLHDNT" gene 8607..9390 /gene="COXIII" CDS 8607..9390 /gene="COXIII" /EC_number="1.9.3.1" /function="oxidative phosphorylation" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:9390,aa:TERM) /transl_table=2 /product="cytochrome c oxidase subunit III" /protein_id="ABK79125.1" /db_xref="GI:118200648" /translation="MTHQTHAYHMVNPSPWPLTGAFSALLLTSGLVMWFHYNSITLLT LGLLTNILTMYQWWRDVIREGTYQGHHTPIVQKGLRYGMILFIVSEVFFFAGFFWAFY HSSLVPTHDLGGCWPPTGISPLNPLEVPLLNTSVLLASGVSITWAHHSLMEGKRNHMN QALLITIMLGLYFTILQASEYFETSFSISDGIYGSTFFMATGFHGLHVIIGSTFLIVC LLRQLKFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS" tRNA 9391..9458 /product="tRNA-Gly" /anticodon=(pos:9421..9423,aa:Gly) gene 9459..9806 /gene="ND3" CDS 9459..9806 /gene="ND3" /EC_number="1.6.5.3" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 3" /protein_id="ABK79126.1" /db_xref="GI:118200649" /translation="MNLYTVIFINILLSLTLILVAFWLPQMNLYSEKANPYECGFDPT SSARLPFSMKFFLVAITFLLFDLEIALLLPLPWAIQTIKTSTMMIMAFILVTILSLGL AYEWTQKGLEWTE" tRNA 9808..9876 /product="tRNA-Arg" /anticodon=(pos:9839..9841,aa:Arg) misc_feature 9821..9830 /note="polymorphic region" gene 9878..10174 /gene="ND4L" CDS 9878..10174 /gene="ND4L" /EC_number="1.6.5.3" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 4L" /protein_id="ABK79127.1" /db_xref="GI:118200650" /translation="MPSTFFNLTMAFSLSLLGTLMFRSHLMSTLLCLEGMVLSLFIMT SVTSLNSNSMSSMPIPITILVFAACEAAVGLALLVKVSNTYGTDYVQNLNLLQC" gene 10168..11545 /gene="ND4" CDS 10168..11545 /gene="ND4" /EC_number="1.6.5.3" /function="oxidative phosphorylation" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:11545,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 4" /protein_id="ABK79128.1" /db_xref="GI:118200651" /translation="MLKIILPSLMLLPLTWLSSPKKTWTNVTSYSFLISLTSLTLLWQ TDENYKNFSNMFSSDPLSTPLIILTAWLLPLMLMASQNHLKKDNNVLQKLYISMLISL QILLIMTFSATELIMFYILFEATLIPTLIIITRWGNQTERLNAGIYFLFYTLIGSIPL LIALILIQNHVGTLNLMILSFTTHTLDASWSNNLLWLACMMAFLIKMPLYGVHLWLPK AHVEAPIAGSMILAAILLKLGSYGMIRISIILDPLTKYMAYPFILLSLWGMIMTSSIC LRQTDLKSLIAYSSVSHMALVIASIMIQTPWSFMGATMLMIAHGLTSSLLFCLANSNY ERIHSRTMIMARGLQMVFPLMATWWLMASLANLALPPSINLMGELFITMSLFSWSNFT IILMGINIIITGMYSMYMIITTQRGKLTNHMINLQPSHTRELTLMALHMIPLILLTTS PKLITGLTM" tRNA 11546..11613 /product="tRNA-His" /anticodon=(pos:11576..11578,aa:His) tRNA 11614..11672 /product="tRNA-Ser" /note="codons recognized: AGY" /anticodon=(pos:11633..11635,aa:Ser) tRNA 11673..11743 /product="tRNA-Leu" /note="codons recognized: CUN" /anticodon=(pos:11704..11706,aa:Leu) gene 11743..13566 /gene="ND5" CDS 11743..13566 /gene="ND5" /EC_number="1.6.5.3" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 5" /protein_id="ABK79129.1" /db_xref="GI:118200652" /translation="MNIFTTSILLIFILLLSPILISMSNLIKHINFPLYTTTSIKFSF IISLLPLLMFFHNNMEYMITTWHWVTMNSMELKMSFKTDFFSILFTSVALFVTWSIMQ FSSWYMHSDPNINRFIKYLTLFLITMLILTSANNMFQLFIGWEGVGIMSFLLIGWWYG RTDANTAALQAILYNRIGDIGFILAMVWFSLNMNSWELQQIMFSNNNDNLIPLMGLLI AATGKSAQFGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLVRFHPLTTNNNFILTT MLCLGALTTLFTAICALTQNDIKKIIAFSTSSQLGLMMVTLGMNQPHLAFLHICTHAF FKAMLFMCSGSIIHSLADEQDIRKMGNITKIMPFTSSCLVIGSLALTGMPFLTGFYSK DLIIEAINTCNTNAWALLITLIATSMTAMYSMRIIYFVTMTKPRFPPLISINENDPDL MNPIKRLAFGSIFAGFVISYNIPPTSIPVLTMPWFLKTTALIISVLGFLIALELNNLT MKLSMNKANPYSSFSTLLGFFPSIIHRITPMKSLNLSLKTSLTLLDLIWLEKTIPKST STLHTNMTTLTTNQKGLIKLYFMSFLINIILIIILYSINLE" gene complement(13553..14071) /gene="ND6" CDS complement(13553..14071) /gene="ND6" /EC_number="1.6.5.3" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 6" /protein_id="ABK79130.1" /db_xref="GI:118200653" /translation="MNNYIFVLSSLFLVGCLGLALKPSPIYGGLGLIVSGFVGCLMVL GFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPETWGSNWLILGFLVLGVIMEVFL ICVLNYYDEVGVINLDGLGDWLMYEVDDVGVMLEGGIGVAAMYSCATWMMVVAGWSLF AGIFIIIEITRD" tRNA complement(14072..14140) /product="tRNA-Glu" /anticodon=(pos:complement(14108..14110),aa:Glu) gene 14146..15289 /gene="CYTB" CDS 14146..15289 /gene="CYTB" /EC_number="1.10.2.2" /function="oxidative phosphorylation" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:15289,aa:TERM) /transl_table=2 /product="cytochrome b" /protein_id="ABK79131.1" /db_xref="GI:118200654" /translation="MTNMRKTHPLFKIINHSFIDLPAPSNISSWWNFGSLLGVCLMVQ IITGLFLAMHYTSDTMTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGL YYGSYTFMETWNIGVLLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTL VEWIWGGFSVDKATLTRFFAFHFILPFIIAALAIVHLLFLHETGSNNPTGLNSDADKI PFHPYYTIKDILGILIMFLILMTLVLFFPDMLGDPDNYMPANPLNTPPHIKPEWYFLF AYAILRSIPNKLGGVLALILSILILALMPFLHTSKQRSLMFRPITQILYWILVANLLI LTWIGGQPVEHPFIIIGQLASISYFSIILILMPISGIIEDKMLKLYP" tRNA 15290..15356 /product="tRNA-Thr" tRNA complement(15357..15423) /product="tRNA-Pro" /anticodon=(pos:complement(15391..15393),aa:Pro) D-loop 15424..16300 misc_feature 15452..15510 /note="ETAS1; extended termination associated sequence 1" misc_feature 15516..15559 /note="ETAS2; extended termination associated sequence 2" misc_feature 16036..16059 /note="CSB1; conserved sequencing block 1" misc_feature 16090..16105 /note="CSB2; conserved sequencing block 2" misc_feature 16115..16132 /note="CSB3; conserved sequencing block 3" ORIGIN 1 gttaatgtag cttaataaca aagcaaagca ctgaaaatgc ttagatggat aattgtatcc 61 cataaacaca aaggtttggt cctggcctta taattaatta gaggtaaaat tacacatgca 121 aacctccata gaccggtgta aaatccctta aacatttact taaaatttaa ggagagggta 181 tcaagcacat taaaatagct taagacacct tgcctagcca cacccccacg ggactcagca 241 gtgataaata ttaagcaata aacgaaagtt tgactaagtt atacctctta gggttggtaa 301 atttcgtgcc agccaccgcg gtcatacgat taacccaaac taattatctt cggcgtaaaa 361 cgtgtcaact ataaataaat aaatagaatt aaaatccaac ttatatgtga aaattcattg 421 ttaggaccta aactcaataa cgaaagtaat tctagtcatt tataatacac gacagctaag 481 acccaaactg ggattagata ccccactatg cttagccata aacctaaata attaaattta 541 acaaaactat ttgccagaga actactagcc atagcttaaa actcaaagga cttggcggta 601 ctttatatcc atctagagga gcctgttcta taatcgataa accccgctct acctcaccat 661 ctcttgctaa ttcagcctat ataccgccat cttcagcaaa ccctaaaaag gtattaaagt 721 aagcaaaaga atcaaacata aaaacgttag gtcaaggtgt agccaatgaa atgggaagaa 781 atgggctaca ttttcttata aaagaacatt actataccct ttatgaaact aaaggactaa 841 ggaggattta gtagtaaatt aagaatagag agcttaattg aattgagcaa tgaagtacgc 901 acacaccgcc cgtcaccctc ctcaaattaa attaaactta acataattaa tttctagaca 961 tccgtttatg agaggagata agtcgtaaca aggtaagcat actggaaagt gtgcttggaa 1021 taatcatagt gtagcttaat attaaagcat ctggcctaca cccagaagat ttcatgacca 1081 atgaacactc tgaactaatc ctagccctag ccctacacaa atataattat actattatat 1141 aaatcaaaac atttatccta ctaaaagtat tggagaaaga aattcgtaca tctaggagct 1201 atagaactag taccgcaagg gaaagatgaa agactaatta aaagtaagaa caagcaaaga 1261 ttaaaccttg taccttttgc ataatgaact aactagaaaa cttctaacta aaagaattac 1321 agctagaaac cccgaaacca aacgagctac ctaaaaacaa ttttatgaat caactcgtct 1381 atgtggcaaa atagtgagaa gatttttagg tagaggtgaa aagcctaacg agcttggtga 1441 tagctggtta cccaaaaaat gaatttaagt tcaattttaa acttgctaaa aaaacaacaa 1501 aatcaaaaag taagtttaga ttatagccaa aagagggaca gctcttctgg aacggaaaaa 1561 acctttaata gtgaataatt aacaaaacag cttttaacca ttgtaggcct aaaagcagcc 1621 accaataaag aaagcgttca agctcaacat aaaatttcaa ttaattccat aatttacacc 1681 aacttcctaa acttaaaatt gggttaatct ataactttat agatgcaaca ctgttagtat 1741 gagtaacaag aattccaatt ctccaggcat acgcgtataa caactcggat aaccattgtt 1801 agttaatcag actataggca ataatcacac tataaataat ccacctataa cttctctgtt 1861 aacccaacac cggaatgcct aaaggaaaga tccaaaaaga taaaaggaac tcggcaaaca 1921 agaaccccgc ctgtttacca aaaacatcac ctctagcatt acaagtatta gaggcactgc 1981 ctgcccagtg actaaagttt aacggccgcg gtatcctgac cgtgcaaagg tagcataatc 2041 acttgttcct taattaggga ctagcatgaa cggctaaacg agggtccaac tgtctcttat 2101 ctttaatcag tgaaattgac ctttcagtga agaggctgaa atataataat aagacgagaa 2161 gaccctatgg agcttaaatt atataactta tctatttaat ttattaaacc taatggccca 2221 aaaactatag tataagtttg aaatttcggt tggggtgacc tcggagaata aaaaatcctc 2281 cgaatgatta taacctagac ttacaagtca aagtaaaatc aacatatctt attgacccag 2341 atatattttg atcaacggac caagttaccc tagggataac agcgcaatcc tatttaagag 2401 ttcatatcga caattagggt ttacgacctc gatgttggat caggacatcc caatggtgta 2461 gaagctatta atggttcgtt tgttcaacga ttaaagtcct acgtgatctg agttcagacc 2521 ggagcaatcc aggtcggttt ctatctattt acgatttctc ccagtacgaa aggacaagag 2581 aaatagagcc accttacaaa taagcgctct caacttaatt tatgaataaa atctaaataa 2641 aatatatacg tacaccctct aacctagaga aggttattag ggtggcagag ccaggaaatt 2701 gcgtaagact taaaaccttg ttcccagagg ttcaaatcct ctccctaata gtgttcttta 2761 ttaatatcct aacactcctc gtccccattc taatcgccat agccttccta acattagtag 2821 aacgcaaaat cttagggtac atacaactac gaaaaggccc taacattgtt ggtccatacg 2881 gcattttaca accatttgca gacgccataa aattatttat aaaagaacca atacgccctt 2941 taacaacctc tatatcctta tttattattg cacctaccct atcactcaca ctagcattaa 3001 gtctatgagt tcccctacca ataccacacc cattaattaa tttaaaccta gggattttat 3061 ttattttagc aacatctagc ctatcagttt actccattct atgatcagga tgagcctcaa 3121 actccaaata ctcactattc ggagctttac gagccgtagc ccaaacaatt tcatatgaag 3181 taaccatagc tattatcctt ttatcagttc tattaataaa tggatcctac tctctacaaa 3241 cacttattac aacccaagaa cacatatgat tacttctgcc agcctgaccc atagccataa 3301 tatgatttat ctcaacccta gcagaaacaa accgggcccc cttcgacctg acagaaggag 3361 aatcagaatt agtatcaggg tttaacgtag aatacgcagc cggcccattc gcgttattct 3421 ttatagcaga gtacactaac attattctaa taaacgccct aacaactatt atcttcctag 3481 gacccctata ctatatcaat ttaccagaac tctactcaac taacttcata atagaagctc 3541 tactactatc atcaacattc ctatggatcc gagcatctta tccacgcttc cgttacgatc 3601 aacttataca tcttctatga aaaaactttc tacccctaac actagcatta tgtatgtgac 3661 atatttcttt accaattttt acagcgggag taccaccata catatagaaa tatgtctgat 3721 aaaagaatta ctttgataga gtaaattata gaggttcaag ccctcttatt tctaggacaa 3781 taggaattga acctacactt aagaattcaa aattctccgt gctacctaaa caccttatcc 3841 taatagtaag gtcagctaat taagctatcg ggcccatacc ccgaaaacgt tggtttaaat 3901 ccttcccgta ctaataaatc ctatcaccct tgccatcatc tacttcacaa tcttcttagg 3961 tcctgtaatc acaatatcca gcaccaacct aatactaata tgagtaggcc tggaattcag 4021 cctactagca attatcccca tactaatcaa caaaaaaaac ccacgatcaa ctgaagcagc 4081 aacaaaatac ttcgtcacac aagcaacagc ctcaataatt atcctcctgg ccatcgtact 4141 caactataaa caactaggaa catgaatatt tcaacaacaa acaaacggtc ttatccttaa 4201 cataacatta atagccctat ccataaaact aggcctcgcc ccattccact tctgattacc 4261 agaagtaact caagggatcc cactgcacat aggacttatt cttcttacat gacaaaaaat 4321 tgctccccta tcaattttaa ttcaaattta cccgctactc aactctacta tcattttaat 4381 actagcaatt acttctattt tcataggggc atgaggagga cttaaccaaa cacaaatacg 4441 aaaaattata gcctattcat caattgccca cataggatga atattagcaa ttcttcctta 4501 caacccatcc ctcactctac tcaacctcat aatctatatt attcttacag cccctatatt 4561 catagcactt atactaaata actctataac catcaactca atctcacttc tatgaaataa 4621 aactccagca atactaacta taatctcact gatattacta tccctaggag gccttccacc 4681 actaacagga ttcttaccaa aatgaattat catcacagaa cttataaaaa acaactgtct 4741 aattatagca acactcatag caataatagc tctactaaac ctattctttt atactcgcct 4801 aatttattcc acttcactaa caatatttcc aaccaacaat aactcaaaaa taataactca 4861 ccaaacaaaa actaaaccca acctaatatt ttccacccta gctatcataa gcacaataac 4921 cctaccccta gccccccaac taattaccta gaagtttagg atatactagt ccgcgagcct 4981 tcaaagccct aagaaaacac acaagtttaa cttctgataa ggactgtaag acttcatcct 5041 acatctattg aatgcaaatc aattgcttta attaagctaa gacctcaact agattggcag 5101 gaattaaacc tacgaaaatt tagttaacag ctaaataccc tattactggc ttcaatctac 5161 ttctaccgcc gaaaaaaaaa aatggcggta gaagtcttag tagagatttc tctacacctt 5221 cgaatttgca attcgacatg aatatcacct taagacctct ggtaaaaaga ggatttaaac 5281 ctctgtgttt agatttacag tctaatgctt actcagccat tttacctatg ttcattaatc 5341 gttgattatt ctcaaccaat cacaaagata tcggaaccct ctatctacta ttcggagcct 5401 gagcgggaat agtgggtact gcactaagta ttttaattcg agcagaatta ggtcaaccag 5461 gtgcactttt aggagatgac caaatttaca atgttatcgt aactgcccat gcttttgtta 5521 taattttctt catagtaata ccaataataa ttggaggctt tggaaactga cttgtcccac 5581 taataatcgg agccccagat atagcattcc cacgaataaa taatataagt ttttgactcc 5641 taccaccatc atttctcctt ctcctagcat catcaatagt agaagcagga gcaggaacag 5701 gatgaacagt ctacccacct ctagccggaa atctagccca tgcaggagca tcagtagacc 5761 taacaatttt ctcccttcat ttagctggag tgtcatctat tttaggtgca attaatttta 5821 ttaccactat tatcaacatg aaacccccag ccataacaca gtatcaaact ccactatttg 5881 tctgatccgt acttattaca gccgtactgc tcctattatc actaccagtg ctagccgcag 5941 gcattactat actactaaca gaccgcaacc taaacacaac tttctttgat cccgctggag 6001 gaggggaccc aattctctac cagcatctgt tctgattctt tgggcaccca gaagtttata 6061 ttcttatcct cccaggattt ggaattattt cacatgtagt tacttactac tccggaaaaa 6121 aagaaccttt cggctatata ggaatagtat gagcaataat gtctattggc tttctaggct 6181 ttattgtatg agcccaccac atattcacag taggattaga tgtagacaca cgagcttact 6241 ttacatcagc cactataatt atcgcaattc ctaccggtgt caaagtattt agctgacttg 6301 caaccctaca cggaggtaat attaaatgat ctccagctat actatgagcc ttaggcttta 6361 ttttcttatt tacagttggt ggtctaaccg gaattgtttt atccaactca tcccttgaca 6421 tcgtgcttca cgatacatac tatgtagtag cccatttcca ctatgttcta tcaatgggag 6481 cagtgtttgc tatcatagca ggatttgttc actgattccc attattttca ggcttcaccc 6541 tagatgacac atgagcaaaa gcccacttcg ccatcatatt cgtaggagta aacataacat 6601 tcttccctca acatttcctg ggcctttcag gaataccacg acgctactca gactacccag 6661 atgcttacac cacatgaaac actgtctctt ctataggatc atttatttca ctaacagctg 6721 ttctcatcat gatctttata atttgagagg cctttgcttc aaaacgagaa gtaatatcag 6781 tatcgtatgc ttcaacaaat ttagaatgac ttcatggctg ccctccacca tatcacacat 6841 tcgaggaacc aacctatgta aaagtaaaat aagaaaggaa ggaatcgaac cccctaaaat 6901 tggtttcaag ccaatctcat atcctatatg tctttctcaa taagatatta gtaaaatcaa 6961 ttacataact ttgtcaaagt taaattatag atcaataatc tatatatctt atatggccta 7021 cccattccaa cttggtctac aagacgccac atcccctatt atagaagagc taataaattt 7081 ccatgatcac acactaataa ttgttttcct aattagctcc ttagtcctct atatcatctc 7141 gctaatatta acaacaaaac taacacatac aagcacaata gatgcacaag aagttgaaac 7201 catttgaact attctaccag ctgtaatcct tatcataatt gctctcccct ctctacgcat 7261 tctatatata atagacgaaa tcaacaaccc cgtattaacc gttaaaacca tagggcacca 7321 atgatactga agctacgaat atactgacta tgaagaccta tgctttgatt catatataat 7381 cccaacaaac gacctaaaac ctggtgaact acgactgcta gaagttgata accgagtcgt 7441 tctgccaata gaacttccaa tccgtatatt aatttcatct gaagacgtcc tccactcatg 7501 agcagtcccc tccctaggac ttaaaactga tgccatccca ggccgactaa atcaagcaac 7561 agtaacatca aaccgaccag ggttattcta tggccaatgc tctgaaattt gtggatctaa 7621 ccatagcttt atgcccattg tcctagaaat ggttccacta aaatatttcg aaaactgatc 7681 tgcttcaata atttaatttc actatgaagc taagagcgtt aaccttttaa gttaaagtta 7741 gagaccttaa aatctccata gtgatatgcc acaactagat acatcaacat gatttatcac 7801 aattatctca tcaataatta ccctatttat cttatttcaa ctaaaagtct catcacaaac 7861 attcccactg gcaccttcac caaaatcact aacaaccata aaagtaaaaa ccccttgaga 7921 attaaaatga acgaaaatct atttgcctca ttcattaccc caacaataat aggattccca 7981 atcgttgtag ccatcattat atttccttca atcctattcc catcctcaaa acgcctaatc 8041 aacaaccgtc tccattcttt ccaacactga ctagttaaac ttattatcaa acaaataatg 8101 ctaatccaca caccaaaagg acgaacatga accctaataa ttgtttccct aatcatattt 8161 attggatcaa caaatctcct aggcctttta ccacatacat ttacacctac tacccaacta 8221 tccataaatc taagtatagc cattccacta tgagctggag ccgtaattac aggcttccga 8281 cacaaactaa aaagctcact tgcccacttc cttccacaag gaactccaat ttcactaatt 8341 ccaatactta ttattattga aacaattagc ctatttattc aaccaatggc attagcagtc 8401 cggcttacag ctaacattac tgcaggacac ttattaatac acctaatcgg aggagctact 8461 ctagtattaa taaatattag cccaccaaca gctaccatta catttattat tttacttcta 8521 ctcacaattc tagaatttgc agtagcatta attcaagcct acgtattcac cctcctagta 8581 agcctatatc tacatgataa tacataatga cccaccaaac tcatgcatat cacatagtta 8641 atccaagtcc atgaccatta actggagcct tttcagccct ccttctaaca tcaggtctag 8701 taatatgatt tcactataat tcaattacac tattaaccct tggcctactc accaatatcc 8761 tcacaatata tcaatgatga cgagacgtaa ttcgtgaagg aacctaccaa ggccaccaca 8821 ctcctattgt acaaaaagga ctacgatatg gtataattct attcatcgtc tcggaagtat 8881 ttttctttgc aggattcttc tgagcgttct atcattctag cctcgtacca acacatgatc 8941 taggaggctg ctgacctcca acaggaattt caccacttaa ccctctagaa gtcccactac 9001 ttaatacttc agtacttcta gcatcaggtg tttcaattac atgagctcat catagcctta 9061 tagaaggtaa acgaaaccac ataaatcaag ccctactaat taccattata ctaggacttt 9121 acttcaccat cctccaagct tcagaatact ttgaaacatc attctccatt tcagatggta 9181 tctatggttc tacattcttc atggctactg gattccatgg actccatgta attattggat 9241 caacattcct tattgtttgc ctactacgac aactaaaatt tcacttcaca tcaaaacatc 9301 acttcggatt tgaagccgca gcatgatact gacattttgt agacgtagtc tgacttttcc 9361 tatacgtctc catttattga tgaggatctt actcccttag tataattaat ataactgact 9421 tccaattagt agattctgaa taaacccaga agagagtaat caacctgtac actgttatct 9481 tcattaatat tttattatcc ctaacgctaa ttctagttgc attctgactc ccccaaataa 9541 atctgtactc agaaaaagca aatccatatg aatgcggatt cgaccctaca agctctgcac 9601 gtctaccatt ctcaataaaa tttttcttgg tagcaattac atttctatta tttgacctag 9661 aaattgctct tctacttcca ctaccatgag caattcaaac aattaaaacc tctactataa 9721 taattatagc ctttattcta gtcacaattc tatctctagg cctagcatat gaatgaacac 9781 aaaaaggatt agaatgaaca gagtaaatgg taattagttt aaaaaaaaat taatgatttc 9841 gactcattag attatgatga tgttcataat taccaatatg ccatctacct tcttcaacct 9901 caccatagcc ttctcactat cacttctagg gacacttata tttcgctctc acctaatatc 9961 cacattacta tgcctggaag gcatagtatt atccttattt attataactt cagtaacttc 10021 cctaaactcc aactccataa gctccatacc aatccccatc accatcttag ttttcgcagc 10081 ctgcgaagca gctgtaggac tagccctact agtaaaagtt tcaaacacgt acggaacaga 10141 ttacgtccaa aatctcaacc tactacaatg ctaaaaatta ttcttccctc actaatgcta 10201 ctaccactaa cctgactatc aagccctaaa aaaacctgaa caaacgtaac ctcatatagt 10261 tttctaatta gtttaaccag cctaacactt ctatgacaaa ccgacgaaaa ttataaaaac 10321 ttttcaaata tattctcctc agacccccta tccacaccat taattatttt aacagcctga 10381 ttactgccac taatattaat agctagccaa aaccacctaa aaaaagataa taacgtacta 10441 caaaaactct acatctcaat actaatcagc ttacaaattc tcctaatcat aaccttttca 10501 gcaactgaac taattatatt ttatatttta tttgaagcaa ccttaatccc aacacttatt 10561 attattaccc gatgagggaa ccaaactgaa cgcctaaacg cagggattta tttcctattt 10621 tataccctaa tcggttctat tccactgcta attgccctca tcttaatcca aaaccatgta 10681 ggaaccctaa acctcataat tttatcattc acaacacaca ccttagacgc ttcatgatct 10741 aacaacttac tatggttggc atgcataata gcatttctta ttaaaatacc attatatgga 10801 gttcacctat gactaccaaa agcccatgtt gaagctccaa ttgctgggtc aataattcta 10861 gcagctattc ttctaaaatt aggtagttac ggaataattc gcatctccat tattctagac 10921 ccactaacaa aatatatagc ataccccttc atccttctct ccctatgagg aataattata 10981 actagctcaa tctgcttacg ccaaacagat ttaaaatcac taatcgccta ctcctcagtt 11041 agccacatag cacttgttat tgcatcaatc ataatccaaa ctccatgaag cttcatagga 11101 gcaacaatac taataatcgc acatggcctc acatcatcac tcctattctg cctagcaaac 11161 tccaactacg aacggatcca cagccgtact ataatcatgg cccgaggact tcaaatggtc 11221 ttcccactta tagccacatg atgactgata gcaagtctag ctaatctagc tctaccccct 11281 tcaatcaatc taataggaga attattcatt accatatcat tattttcttg atcaaacttt 11341 accattattc ttataggaat taacattatt attacaggta tatactcaat atacataatt 11401 attaccaccc aacgcggcaa actaaccaac catataatta acctccaacc ctcacacaca 11461 cgagaactaa cactaatagc ccttcacata attccactta ttcttctaac taccagtcca 11521 aaactaatta caggcctgac aatatgtgaa tatagtttac aaaaaacatt agactgtgaa 11581 tctgacaaca ggaaataaac ctccttattc accaagaaag attgcaagaa ctgctaattc 11641 atgcttccat gtttaaaaac atggctttct tacttttata ggataatagt aatccattgg 11701 tcttaggaac caaaaacctt ggtgcaaatc caaataaaag taatcaatat tttcacaacc 11761 tcaatcttat taatcttcat tcttctacta tccccaatcc taatttcaat atcaaaccta 11821 attaaacaca tcaacttccc actgtacacc accacatcaa tcaaattctc cttcattatt 11881 agcctcttac ccctattaat atttttccac aataatatag aatatataat tacaacctgg 11941 cactgagtca ccataaattc aatagaactt aaaataagct tcaaaactga ctttttctct 12001 atcctgttta catctgtagc cctttttgtc acatgatcaa ttatacaatt ctcttcatga 12061 tatatacact cagacccaaa catcaatcga ttcattaaat atcttacact attcctgatt 12121 accatgctta tcctcacctc agccaacaac atatttcaac ttttcattgg ctgagaaggg 12181 gtgggaatta tatctttcct actaattgga tgatggtacg gacgaacaga cgcaaatact 12241 gcagccctac aagcaatcct ctataaccgc atcggagaca tcggattcat tttagctata 12301 gtttgatttt ccctaaacat aaactcatga gaacttcaac agattatatt ctccaacaac 12361 aacgacaatc taattccact tataggccta ttaatcgcag ctacaggaaa atcagcacaa 12421 tttggcctcc acccatgact accatcagca atagaaggcc ctacaccagt ttcagcacta 12481 ctacactcaa gtacaatagt agttgcagga attttcctac tggtccgatt ccaccccctc 12541 acgactaata ataactttat tttaacaact atactttgcc tcggagccct aaccacatta 12601 tttacagcta tttgtgctct cacccaaaac gacatcaaaa aaatcattgc cttctctaca 12661 tcaagccaac taggcctgat aatagtgacg ctaggaataa accaaccaca cctagcattc 12721 ctacacatct gtacccacgc attcttcaaa gctatactct ttatatgctc tggctcaatc 12781 attcatagcc tggcagacga acaagacatc cgaaaaatag gaaacatcac aaaaatcata 12841 ccattcacat catcatgcct agtaatcgga agcctcgccc tcacaggaat accattccta 12901 acagggttct actcaaaaga cctaattatt gaagcaatta atacctgcaa caccaacgcc 12961 tgagccctac taattacact aatcgccact tctataacag ctatgtacag catacgaatc 13021 atttacttcg taacaataac aaaaccgcgt tttccccccc taatctccat taacgaaaat 13081 gacccagacc tcataaaccc aatcaaacgc ctagcattcg gaagcatctt tgcaggattt 13141 gtcatctcat ataatattcc accaaccagc attccagtcc tcacaatacc atgattttta 13201 aaaaccacag ccctaattat ttcagtatta ggattcctaa tcgcactaga actaaacaac 13261 ctaaccataa aactatcaat aaataaagca aatccatatt catccttctc aactttactg 13321 gggtttttcc catctattat tcaccgcatt acacccataa aatctctcaa cctaagccta 13381 aaaacatccc taactctcct agacttgatc tggttagaaa aaaccatccc aaaatccacc 13441 tcaactcttc acacaaacat aaccacttta acaaccaacc aaaaaggctt aattaaattg 13501 tactttatat cattcctaat taacatcatc ttaattatta tcttatactc aattaatctc 13561 gagtaatctc gataataata aaaatacccg caaacaaaga tcacccagct actaccatca 13621 ttcaagtagc acaactatat attgccgcta ccccaatccc tccttccaac ataactccaa 13681 catcatcaac ctcatacatc aaccaatctc ccaaaccatc aagattaatt actccaactt 13741 catcataata attaagcaca caaattaaaa aaacctctat aatcaccccc aatactaaaa 13801 aacccaaaat taatcagtta gatccccaag tctctggata ttcctcagta gctatagcag 13861 tcgtatatcc aaacacaacc aacatccccc ctaaataaat taaaaaaact attaaaccta 13921 aaaacgatcc accaaaccct aaaaccatta aacaaccaac aaacccacta acaattaaac 13981 ctaaacctcc ataaataggt gaaggcttta atgctaaccc aagacaacca accaaaaata 14041 atgaacttaa aacaaaaata taattattca ttatttctac acagcattca actgcgacca 14101 atgacatgaa aaatcatcgt tgtaattcaa ctacagaaac acctaatgac aaacatacga 14161 aaaacacacc cattatttaa aattattaac cactcattca ttgacctacc tgccccatcc 14221 aacatttcat catgatgaaa ctttgggtcc cttctaggag tctgcctaat agtccaaatc 14281 attacaggtc ttttcttagc catacactac acatcagata caataacagc cttttcatca 14341 gtaacacaca tttgtcgaga cgtaaattac gggtgactaa tccgatatat acacgcaaac 14401 ggagcctcaa tattttttat ttgcttattc cttcatgtcg gacgaggctt atattatgga 14461 tcatatacat ttatagaaac ctgaaacatt ggagtacttc tactgttcgc agtcatagcc 14521 acagcattta taggctacgt ccttccatga ggacaaatat cattctgagg tgccacagtt 14581 attacaaacc tcctatcagc catcccatat attggaacaa ccctagtcga atgaatttga 14641 gggggcttct cagtagacaa agccaccttg acccgattct tcgctttcca cttcatctta 14701 ccatttatta tcgcggccct agcaatcgtt cacctcctct tcctccacga aacaggatca 14761 aacaacccaa caggattaaa ctcagatgca gataaaattc catttcaccc ctactataca 14821 atcaaagata tcctaggtat cctaatcata ttcttaattc tcataaccct agtattattt 14881 ttcccagaca tactaggaga cccagacaac tacataccag ctaatccact aaacacccca 14941 ccccatatta aacccgaatg atatttccta tttgcatacg ccattctacg ctcaatcccc 15001 aataaactag gaggtgtcct agccttaatc ttatctatcc taattttagc cctaatacct 15061 ttccttcata cctcaaagca acgaagccta atattccgcc caatcacaca aattttgtac 15121 tgaatcctag tagccaacct acttatctta acctgaattg ggggccaacc agtagaacac 15181 ccatttatta tcattggcca actagcctcc atctcatact tctcaatcat cttaattctt 15241 ataccaatct caggaattat cgaagacaaa atactaaaat tatatccatg tcttgatagt 15301 ataaacatta ctctggtctt gtaaacctga aatgaagatc ttctcttctc aagacatcaa 15361 gaagaaggag ctactcccca ccaccagcac ccaaagctgg tattctaatt aaactacttc 15421 ttgagtacat aaatttacat agtacaacag tacatttatg tatatcgtac attaaactat 15481 tttccccaag catataagct agtacattaa atcaatggtt caggtcataa aataatcatc 15541 aacataaatc aatatatata ccatgaatat tatcttaaac acattaaact aatgttataa 15601 ggacatatct gtgttatctg acatacacca tacagtcata aactcttctc ttccatatga 15661 ctatcccctt ccccatttgg tctattaatc taccatcctc cgtgaaacca acaacccgcc 15721 caccaatgcc cctcttctcg ctccgggccc attaaacttg ggggtagcta aactgaaact 15781 ttatcagaca tctggttctt acttcagggc catcaaatgc gttatcgccc atacgttccc 15841 cttaaataag acatctcgat ggtatcgggt ctaatcagcc catgaccaac ataactgtgg 15901 tgtcatgcat ttggtatctt tttattttgg cctactttca tcaacatagc cgtcaaggca 15961 tgaaaggaca gcacacagtc tagacgcacc tacggtgaag aatcattagt ccgcaaaacc 16021 caatcaccta aggctaatta ttcatgcttg ttagacataa atgctactca ataccaaatt 16081 ttaactctcc aaacccccca ccccctcctc ttaatgccaa accccaaaaa cactaagaac 16141 ttgaaagaca tataatatta actatcaaac cctatgtcct gatcaattct agtagttccc 16201 aaaatatgac ttatatttta gtacttgtaa aaattttaca aaatcatgtt ccgtgaacca 16261 aaactctaat catactctat tacgcaataa acattaacaa //