LOCUS AY339581 16570 bp DNA circular PRI 10-OCT-2007 DEFINITION Homo sapiens isolate F180 (PL61) mitochondrion, complete genome. ACCESSION AY339581 VERSION AY339581.2 GI:110609974 KEYWORDS . SOURCE mitochondrion Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 16570) AUTHORS Finnila,S., Lehtonen,M.S. and Majamaa,K. TITLE Phylogenetic network for European mtDNA JOURNAL Am. J. Hum. Genet. 68 (6), 1475-1484 (2001) PUBMED 11349229 REFERENCE 2 (bases 1 to 16570) AUTHORS Moilanen,J.S., Finnila,S. and Majamaa,K. TITLE Lineage-Specific Selection in Human mtDNA: Lack of Polymorphisms in a Segment of MTND5 Gene in Haplogroup J JOURNAL Mol. Biol. Evol. 20 (12), 2132-2142 (2003) PUBMED 12949126 REFERENCE 3 (bases 1 to 16570) AUTHORS Moilanen,J.S., Finnila,S., Lehtonen,M.S. and Majamaa,K. TITLE Direct Submission JOURNAL Submitted (11-JUL-2003) Biocenter and Department of Neurology, University of Oulu, P.O. Box 5000, Oulu FIN-90014, Finland REFERENCE 4 (bases 1 to 16570) AUTHORS Moilanen,J.S., Finnila,S., Lehtonen,M.S. and Majamaa,K. TITLE Direct Submission JOURNAL Submitted (20-JUL-2006) Biocenter and Department of Neurology, University of Oulu, P.O. Box 5000, Oulu FIN-90014, Finland REMARK Sequence update by submitter COMMENT On Jul 20, 2006 this sequence version replaced gi:32894815. FEATURES Location/Qualifiers source 1..16570 /organism="Homo sapiens" /organelle="mitochondrion" /mol_type="genomic DNA" /isolate="F180 (PL61)" /db_xref="taxon:9606" /haplotype="J1" /country="Finland" D-loop complement(join(1..577,16025..16570)) gene 578..648 /gene="TRNF" /note="synonym: MTTF" tRNA 578..648 /gene="TRNF" /product="tRNA-Phe" gene 649..1602 /gene="RNR1" /note="synonym: MTRNR1" rRNA 649..1602 /gene="RNR1" /product="12S ribosomal RNA" gene 1603..1671 /gene="TRNV" /note="synonym: MTTV" tRNA 1603..1671 /gene="TRNV" /product="tRNA-Val" gene 1672..3229 /gene="RNR2" /note="synonym: MTRNR2" rRNA 1672..3229 /gene="RNR2" /product="16S ribosomal RNA" gene 3230..3304 /gene="TRNL1" /note="synonym: MTTL1" tRNA 3230..3304 /gene="TRNL1" /product="tRNA-Leu" gene 3307..4263 /gene="ND1" /note="synonym: MTND1" CDS 3307..4263 /gene="ND1" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 1" /protein_id="AAP91363.1" /db_xref="GI:32894816" /translation="MPMANLLLLIVPILIAMAFLMLTERKILGYMQLRKGPNVVGPYG LLQPFADAMKLFTKEPLKPATSTITLYITAPTLALTIALLLWTPLPMPNPLVNLNLGL LFILATSSLAVYSILWSGWASNSNYALIGALRAVAQTISYEVTLAIILLSTLLMSGSF NLSTLITTQEHLWLLLPSWPLAMMWFISTLAETNRTPFDLAEGESELVSGFNIEYAAG PFALFFMAEYTNIIMMNTLTTTIFLGTTYDALSPELYTTYFVTKTLLLTSLFLWIRTA YPRFRYDQLMHLLWKNFLPLTLALLMWHVSMPITISSIPPQT" gene 4263..4331 /gene="TRNI" /note="synonym: MTTI" tRNA 4263..4331 /gene="TRNI" /product="tRNA-Ile" gene complement(4329..4400) /gene="TRNQ" /note="synonym: MTTQ" tRNA complement(4329..4400) /gene="TRNQ" /product="tRNA-Gln" gene 4402..4469 /gene="TRNM" /note="synonym: MTTM" tRNA 4402..4469 /gene="TRNM" /product="tRNA-Met" gene 4470..5513 /gene="ND2" /note="synonym: MTND2" CDS 4470..5513 /gene="ND2" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 2" /protein_id="AAP91364.1" /db_xref="GI:32894817" /translation="MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVL TKKMNPRSTEAAIKYFLTQATASMILLMAILFNNMLSGQWTMTNTTNQYSSLMIMMAM AMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPSLNVSLLLTLSIL SIMAGSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLL LNLNSSTTTLLLSRTWNKLTWLTPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSL IIPTIMATITLLNLYFYLRLIYSTSITLLPMSNNVKMKWQFEHTKPTPFLPTLITLTT LLLPISPFMLMIL" gene 5512..5576 /gene="TRNW" /note="synonym: MTTW" tRNA 5512..5576 /gene="TRNW" /product="tRNA-Trp" gene complement(5587..5655) /gene="TRNA" /note="synonym: MTTA" tRNA complement(5587..5655) /gene="TRNA" /product="tRNA-Ala" gene complement(5657..5729) /gene="TRNN" /note="synonym: MTTN" tRNA complement(5657..5729) /gene="TRNN" /product="tRNA-Asn" gene complement(5761..5826) /gene="TRNC" /note="synonym: MTTC" tRNA complement(5761..5826) /gene="TRNC" /product="tRNA-Cys" gene complement(5826..5891) /gene="TRNY" /note="synonym: MTTY" tRNA complement(5826..5891) /gene="TRNY" /product="tRNA-Tyr" gene 5904..7445 /gene="COX1" /note="synonym: MTCO1" CDS 5904..7445 /gene="COX1" /note="cytochrome c oxidase I" /codon_start=1 /transl_table=2 /product="cytochrome c oxidase subunit I" /protein_id="AAP91365.1" /db_xref="GI:32894818" /translation="MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQP GNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSF WLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILG AINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTT FFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWA MMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKW SAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGG FIHWFPLFSGYTLDQTYAKIHFTIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTW NILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEEP VYMKS" gene complement(7445..7516) /gene="TRNS1" /note="synonym: MTTS1" tRNA complement(7445..7516) /gene="TRNS1" /product="tRNA-Ser" gene 7518..7585 /gene="TRND" /note="synonym: MTTD" tRNA 7518..7585 /gene="TRND" /product="tRNA-Asp" gene 7586..8269 /gene="COX2" /note="synonym: MTCO2" CDS 7586..8269 /gene="COX2" /note="cytochrome c oxidase II" /codon_start=1 /transl_table=2 /product="cytochrome c oxidase subunit II" /protein_id="AAP91366.1" /db_xref="GI:32894819" /translation="MAHAAQVGLQDATSPIMEELITFHDHALMIIFLICFLVLYALFL TLTTKLTNTNISDAQEMETVWTILPAIILVLIALPSLRILYMTDEVNDPSLTIKSIGH QWYWTYEYTDYGGLIFNSYMLPPLFLEPGDLRLLDVDNRVVLPIEAPIRMMITSQDVL HSWAVPTLGLKTDAIPGRLNQTTFTATRPGVYYGQCSEICGANHSFMPIVLELIPLKI FEMGPVFTL" gene 8296..8365 /gene="TRNK" /note="synonym: MTTK" tRNA 8296..8365 /gene="TRNK" /product="tRNA-Lys" gene 8367..8573 /gene="ATP8" /note="synonym: MTATP8" CDS 8367..8573 /gene="ATP8" /note="ATP synthase 8" /codon_start=1 /transl_table=2 /product="ATP synthase F0 subunit 8" /protein_id="AAP91367.1" /db_xref="GI:32894820" /translation="MPQLNTTVWPTMITPMLLTLFLITQLKMLNTNYHLPPSPKPMKM KNYNKPWEPKWTKICSLHSLPPQS" gene 8528..9208 /gene="ATP6" /note="synonym: MTATP6" CDS 8528..9208 /gene="ATP6" /note="ATP synthase 6" /codon_start=1 /transl_table=2 /product="ATP synthase F0 subunit 6" /protein_id="AAP91368.1" /db_xref="GI:32894821" /translation="MNENLFASFITPTILGLPAAVLIILFPPLLIPTSKYLINNRLIT TQQWLIKLTSKQMMTMHNTKGRTWSLMLVSLIIFIATTNLLGLLPHSFTPTTQLSMNL AMAIPLWAGAVIMGFRSKIKNALAHFLPQGTPTPLIPMLVIIETISLLIQPMALAVRL TANITAGHLLMHLIGSATLAMSTINLPSTLIIFTILILLTILEIAVALIQAYVFTLLV SLYLHDNT" gene 9208..9991 /gene="COX3" /note="synonym: MTCO3" CDS 9208..9991 /gene="COX3" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:9991,aa:TERM) /transl_table=2 /product="cytochrome c oxidase subunit III" /protein_id="AAP91369.1" /db_xref="GI:32894822" /translation="MTHQSHAYHMVKPSPWPLTGALSALLMTSGLAMWFHFHSMTLLM LGLLTNTLTMYQWWRDVTRESTYQGHHTPPVQKGLRYGMILFITSEVFFFAGFFWAFY HSSLAPTPQLGGHWPPTGITPLNPLEVPLLNTSVLLASGVSITWAHHSLMENNRNQMI QALLITILLGLYFTLLQASEYFESPFTISDGIYGSTFFVATGFHGLHVIIGSTFLTIC FIRQLMFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS" gene 9992..10059 /gene="TRNG" /note="synonym: MTTG" tRNA 9992..10059 /gene="TRNG" /product="tRNA-Gly" gene 10060..10405 /gene="ND3" /note="synonym: MTND3" CDS 10060..10405 /gene="ND3" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:10405,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 3" /protein_id="AAP91370.1" /db_xref="GI:32894823" /translation="MNFALILMINTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPM SPARVPFSMKFFLVAITFLLFDLEIALLLPLPWALQTTNLPLMVMSSLLLIIILALSL AYEWLQKGLDWAE" gene 10406..10470 /gene="TRNR" /note="synonym: MTTR" tRNA 10406..10470 /gene="TRNR" /product="tRNA-Arg" gene 10471..10767 /gene="ND4L" /note="synonym: MTND4L" CDS 10471..10767 /gene="ND4L" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 4L" /protein_id="AAP91371.1" /db_xref="GI:32894824" /translation="MPLIYMNIMLAFTISLLGMLVYRSHLMSSLLCLEGMMLSLFIMA TLMTLNTHSLLANIVPIAMLVFAACEAAVGLALLVSISNTYGLDYVHNLNLLQC" gene 10761..12138 /gene="ND4" /note="synonym: MTND4" CDS 10761..12138 /gene="ND4" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:12138,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 4" /protein_id="AAP91372.1" /db_xref="GI:32894825" /translation="MLKLIVPTIMLLPLTWLSKKHMIWINTTTHSLIISIIPLLFFNQ INNNLFSCSPTFSSDPLTTPLLMLTTWLLPLTIMASQRHLSSEPLSRKKLYLSMLISL QISLIMTFTATELIMFYIFFETTLIPTLAIITRWGNQPERLNAGTYFLFYTLVGSLPL LIALIYTHNTLGSLNILLLTLTAQELSNSWANNLMWLAYTMAFMVKMPLYGLHLWLPK AHVEAPIAGSMVLAAVLLKLGGYGMMRLTLILNPLTKHMAYPFLVLSLWGMIMTSSIC LRQTDLKSLIAYSSISHMALVVTAILIQTPWSFTGAVILMIAHGLTSSLLFCLANSNY ERTHSRIMILSQGLQTLLPLMAFWWLLASLANLALPPTINLLGELSVLVTTFSWSNIT LLLTGLNMLVTALYSLYMFTTTQWGSLTHHINNMKPSFTRENTLMFMHLSPILLLSLN PDIITGFSS" gene 12139..12207 /gene="TRNH" /note="synonym: MTTH" tRNA 12139..12207 /gene="TRNH" /product="tRNA-His" gene 12208..12266 /gene="TRNS2" /note="synonym: MTTS2" tRNA 12208..12266 /gene="TRNS2" /product="tRNA-Ser" gene 12267..12337 /gene="TRNL2" /note="synonym: MTTL2" tRNA 12267..12337 /gene="TRNL2" /product="tRNA-Leu" gene 12338..14149 /gene="ND5" /note="synonym: MTND5" CDS 12338..14149 /gene="ND5" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 5" /protein_id="AAP91373.1" /db_xref="GI:32894826" /translation="MTMHTTMTTLTLTSLIPPILTTLVNPNKKNSYPHYVKSIVASTF IISLFPTTMFMCLDQEVIISNWHWATTQTTQLSLSFKLDYFSMMFIPVALFVTWSIME FSLWYMNSDPNINQFFKYLLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLISWWYA RADANTAAIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLNANPSLTPLLGLLL AAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFHPLAENSPLIQTL TLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAF FKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSK DHIIETANMSYTNAWALSITLIATSLTSAYSTRMILLTLTGQPRFPTLTNINENNPTL LNPIKRLTAGSLFAGFLITNNISPASPFQTTIPLYLKLTALAVTFLGLLTALDLNYLT NKLKMKPPLCTFYFSNMLGFYPSITHRTIPYLGLLTSQNLPLLLLDLTWLEKLLPKTI SQHQISTSIITSTQKGMIKLYFLSFFFPLILTLLLIT" gene complement(14150..14674) /gene="ND6" /note="synonym: MTND6" CDS complement(14150..14674) /gene="ND6" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 6" /protein_id="AAP91374.1" /db_xref="GI:32894827" /translation="MMYALFLLSVGLVMGFVGFSSKPSPIYGGLVLIVSGVVGCVIIL NFGGGYMGLMVFLIYLGGMMVVFGYTTAMAIEEYPEAWGSGVEVLVSVLVGLAMEVGL VLWVKEYDGVVVVVNFNSVGSWMIYEGEGSGLIREDPIGAGALYDYGRWLVVVTGWTL FVGVYIVIEIARGN" gene complement(14675..14743) /gene="TRNE" /note="synonym: MTTE" tRNA complement(14675..14743) /gene="TRNE" /product="tRNA-Glu" gene 14748..15888 /gene="CYTB" /note="synonym: MTCYB" CDS 14748..15888 /gene="CYTB" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:15888,aa:TERM) /transl_table=2 /product="cytochrome b" /protein_id="AAP91375.1" /db_xref="GI:32894828" /translation="MTPMRKINPLMKLINHSFIDLPTPSNISAWWNFGSLLGACLILQ ITTGLFLAMHYSPDASTAFSSIAHITRDVNYGWIIRYLHANGASMFFICLFLHIGRGL YYGSFLYSETWNIGIILLLATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDL VQWIWGGYSVDSPTLTRFFTFHFILPFIIAALAALHLLFLHETGSNNPLGITSHSDKI TFHPYYTIKDALGLLLFILSLMTLTLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLF AYTILRSVPNKLGGVLALLLSILILAMIPILHMSKQQSMMFRPLSQSLYWLLAADLLI LTWIGGQPVSYPFTIIGQVASVLYFTTILILMPTISLIENKMLKWA" gene 15889..15954 /gene="TRNT" /note="synonym: MTTT" tRNA 15889..15954 /gene="TRNT" /product="tRNA-Thr" gene complement(15956..16024) /gene="TRNP" /note="synonym: MTTP" tRNA complement(15956..16024) /gene="TRNP" /product="tRNA-Pro" ORIGIN 1 gatcacaggt ctatcaccct attaaccact cacgggagct ctccatgcat ttggtatttt 61 cgtctggggg gtgtgcacgc gatagcattg cgagacgctg gagccggagc accctatgtc 121 gcagtatctg tctttgattc ctgcctcatc ctattattta tcgcacctac gttcaatatt 181 acaggcgaac atacttacta aagtgtgtta attaattaat gcttgtagga cataataata 241 ataattgaat gtctgcacag ccgttttcca cacagacatc ataacaaaaa attttcacca 301 aaccccccct ccccccgctt ctggccacag cacttaaaca catctctgcc aaaccccaaa 361 aacaaagaac cctaacacca gcctaaccag atttcaaatt ttatcttttg gcggtatgca 421 cttttaacag tcacccccca actaacacat tattttcccc tctcactccc atactactaa 481 tctcatcaac acaacccccg cccatcctac ccagcacaca cacaccgctg ctaaccccat 541 accccgaacc aaccaaaccc caaagacacc ccccacagtt tatgtagctt acctcctcaa 601 agcaatacac tgaaaatgtt tagacgggct cacatcaccc cataaacaaa taggtttggt 661 cctagccttt ctattagctc ttagtaagat tacacatgca agcatccccg ttccagtgag 721 ttcaccctct aaatcaccac gatcaaaagg gacaagcatc aagcacgcag caatgcagct 781 caaaacgctt agcctagcca cacccccacg ggaaacagca gtgattaacc tttagcaata 841 aacgaaagtt taactaagct atactaaccc cagggttggt caatttcgtg ccagccaccg 901 cggtcacacg attaacccaa gtcaatagaa gccggcgtaa agagtgtttt agatcacccc 961 ctccccaata aagctaaaac tcacctgagt tgtaaaaaac tccagttgac acaaaataga 1021 ctacgaaagt ggctttaaca tatctgaaca cacaatagct aagacccaaa ctgggattag 1081 ataccccact atgcttagcc ctaaacctca acagttaaat caacaaaact gctcgccaga 1141 acactacgag ccacagctta aaactcaaag gacctggcgg tgcttcatat ccctctagag 1201 gagcctgttc tgtaatcgat aaaccccgat caacctcacc acctcttgct cagcctatat 1261 accgccatct tcagcaaacc ctgatgaagg ctacaaagta agcgcaagta cccacgtaaa 1321 gacgttaggt caaggtgtag cccatgaggt ggcaagaaat gggctacatt ttctacccca 1381 gaaaactacg atagccctta tgaaacttaa gggtcgaagg tggatttagc agtaaactga 1441 gagtagagtg cttagttgaa cagggccctg aagcgcgtac acaccgcccg tcaccctcct 1501 caagtatact tcaaaggaca tttaactaaa acccctacgc atttatatag aggagacaag 1561 tcgtaacatg gtaagtgtac tggaaagtgc acttggacga accagagtgt agcttaacac 1621 aaagcaccca acttacactt aggagatttc aacttaactt gaccgctctg agctaaacct 1681 agccccaaac ccactccacc ttactaccag acaaccttag ccaaaccatt tacccaaata 1741 aagtataggc gatagaaatt gaaacctggc gcaatagata tagtaccgca agggaaagat 1801 gaaaaattat aaccaagcat aatatagcaa ggactaaccc ctataccttc tgcataatga 1861 attaactaga aataactttg caaggagagc caaagctaag acccccgaaa ccagacgagc 1921 tacctaagaa cagctaaaag agcacacccg tctatgtagc aaaatagtgg gaagatttat 1981 aggtagaggc gacaaaccta ccgagcctgg tgatagctgg ttgtccaaga tagaatctta 2041 gttcaacttt aaatttgccc acagaaccct ctaaatcccc ttgtaaattt aactgttagt 2101 ccaaagagga acagctcttt ggacactagg aaaaaacctt gtagagagag taaaaaatct 2161 aacacccata gtaggcctaa aagcagccac caattaagaa agcgttcaag ctcaacaccc 2221 actacctaaa aaatcccaaa catataactg aactcctcac acccaattgg accaatctat 2281 caccctatag aagaactaat gttagtataa gtaacatgaa aacattctcc tccgcataag 2341 cctgcgtcag attaaaacac tgaactgaca attaacagcc caatatctac aatcaaccaa 2401 caagtcatta ttaccctcac tgtcaaccca acacaggcat gctcataagg aaaggttaaa 2461 aaaagtaaaa ggaactcggc aaatcttacc ccgcctgttt accaaaaaca tcacctctag 2521 catcaccagt attagaggca ccgcctgccc agtgacacat gtttaacggc cgcggtaccc 2581 taaccgtgca aaggtagcat aatcacttgt tccttaaata gggacctgta tgaatggctc 2641 cacgagggtt cagctgtctc ttacttttaa ccagtgaaat tgacctgccc gtgaagaggc 2701 gggcatgaca cagcaagacg agaagaccct atggagcttt aatttattaa tgcaaacagt 2761 acctaacaaa cccacaggtc ctaaactacc aaacctgcat taaaaatttc ggttggggcg 2821 acctcggagc agaacccaac ctccgagcag tacatgctaa gacttcacca gtcaaagcga 2881 actactatac tcaattgatc caataacttg accaacggaa caagttaccc tagggataac 2941 agcgcaatcc tattctagag tccatatcaa caatagggtt tacgacctcg atgttggatc 3001 aggacatccc aatggtgcag ccgctattaa aggttcgttt gttcaacgat taaagtccta 3061 cgtgatctga gttcagaccg gagtaatcca ggtcggtttc tatctacttc aaattcctcc 3121 ctgtacgaaa ggacaagaga aataaggcct acttcacaaa gcgccttccc ccgtaaatga 3181 tatcatctca acttagtatt atacccacac ccacccaaga acagggtttg ttaagatggc 3241 agagcccggt aatcgcataa aacttaaaac tttacagtca gaggttcaat tcctcttctt 3301 aacaacatac ccatggccaa cctcctactc ctcattgtac ccattctaat cgcaatggca 3361 ttcctaatgc ttaccgaacg aaaaattcta ggctatatac aactacgcaa aggccccaac 3421 gttgtaggcc cctacgggct actacaaccc ttcgctgacg ccataaaact cttcaccaaa 3481 gagcccctaa aacccgccac atctaccatc accctctaca tcaccgcccc gaccttagct 3541 ctcaccatcg ctcttctact atgaaccccc ctccccatac ccaaccccct ggtcaacctc 3601 aacctaggcc tcctatttat tctagccacc tctagcctag ccgtttactc aatcctctga 3661 tcagggtgag catcaaactc aaactacgcc ctgatcggcg cactgcgagc agtagcccaa 3721 acaatctcat atgaagtcac cctagccatc attctactat caacattact aataagtggc 3781 tcctttaacc tctccaccct tatcacaaca caagaacacc tctgattact cctgccatca 3841 tgacccttgg ccataatatg atttatctcc acactagcag agaccaaccg aacccccttc 3901 gaccttgccg aaggggagtc cgaactagtc tcaggcttca acatcgaata cgccgcaggc 3961 cccttcgccc tattcttcat agccgaatac acaaacatta ttataataaa caccctcacc 4021 actacaatct tcctaggaac aacatatgac gcactctccc ctgaactcta cacaacatat 4081 tttgtcacca agaccctact tctaacctcc ctgttcttat gaattcgaac agcatacccc 4141 cgattccgct acgaccaact catacacctc ctatgaaaaa acttcctacc actcacccta 4201 gcattactta tatgacatgt ctccataccc attacaatct ccagcattcc ccctcaaacc 4261 taagaaatat gtctgataaa agagttactt tgatagagta aataatagga gcttaaaccc 4321 ccttatttct aggactatga gaatcgaacc catccctgag aatccaaaat tctccgtgcc 4381 acctatcaca ccccatccta aagtaaggtc agctaaataa gctatcgggc ccataccccg 4441 aaaatgttgg ttataccctt cccgtactaa ttaatcccct ggcccaaccc gtcatctact 4501 ctaccatctt tgcaggcaca ctcatcacag cgctaagctc gcactgattt tttacctgag 4561 taggcctaga aataaacatg ctagctttta ttccagttct aaccaaaaaa ataaaccctc 4621 gttccacaga agctgccatc aagtatttcc tcacgcaagc aaccgcatcc ataatccttc 4681 taatagctat cctcttcaac aatatactct ccggacaatg aaccataacc aatactacca 4741 atcaatactc atcattaata atcataatgg ctatagcaat aaaactagga atagccccct 4801 ttcacttctg agtcccagag gttacccaag gcacccctct gacatccggc ctgcttcttc 4861 tcacatgaca aaaactagcc cccatctcaa tcatatacca aatctctccc tcactaaacg 4921 taagccttct cctcactctc tcaatcttat ccatcatagc aggcagttga ggtggattaa 4981 accaaaccca gctacgcaaa atcttagcat actcctcaat tacccacata ggatgaataa 5041 tagcagttct accgtacaac cctaacataa ccattcttaa tttaactatt tatattatcc 5101 taactactac cgcattccta ctactcaact taaactccag caccacgacc ctactactat 5161 ctcgcacctg aaacaagcta acatgactaa cacccttaat tccatccacc ctcctctccc 5221 taggaggcct gcccccgcta accggctttt tgcccaaatg ggccattatc gaagaattca 5281 caaaaaacaa tagcctcatc atccccacca tcatagccac catcaccctc cttaacctct 5341 acttctacct acgcctaatc tactccacct caatcacact actccccata tctaacaacg 5401 taaaaataaa atgacagttt gaacatacaa aacccacccc attcctcccc acactcatca 5461 cccttaccac gctactccta cctatctccc cttttatact aataatctta tagaaattta 5521 ggttaaatac agaccaagag ccttcaaagc cctcagtaag ttgcaatact taatttctgt 5581 aacagctaag gactgcaaaa ccccactctg catcaactga acgcaaatca gccactttaa 5641 ttaagctaag cccttactag accaatggga cttaaaccca caaacactta gttaacagct 5701 aagcacccta atcaactggc ttcaatctac ttctcccgcc gccgggaaaa aaggcgggag 5761 aagccccggc aggtttgaag ctgcttcttc gaatttgcaa ttcaatatga aaatcacctc 5821 ggagctggta aaaagaggcc taacccctgt ctttagattt acagtccaat gcttcactca 5881 gccattttac ctcaccccca ctgatgttcg ccgaccgttg actattctct acaaaccaca 5941 aagacattgg aacactatac ctattattcg gcgcatgagc tggagtccta ggcacagctc 6001 taagcctcct tattcgagcc gagctgggcc agccaggcaa ccttctaggt aacgaccaca 6061 tctacaacgt tatcgtcaca gcccatgcat ttgtaataat cttcttcata gtaataccca 6121 tcataatcgg aggctttggc aactgactag ttcccctaat aatcggtgcc cccgatatgg 6181 cgtttccccg cataaacaac ataagcttct gactcttacc tccctctctc ctactcctgc 6241 tcgcatctgc tatagtggag gccggagcag gaacaggttg aacagtctac cctcccttag 6301 cagggaacta ctcccaccct ggagcctccg tagacctaac catcttctcc ttacacctag 6361 caggtgtctc ctctatctta ggggccatca atttcatcac aacaattatc aatataaaac 6421 cccctgccat aacccaatac caaacgcccc tcttcgtctg atccgtccta atcacagcag 6481 tcctacttct cctatctctc ccagtcctag ctgctggcat cactatacta ctaacagacc 6541 gcaacctcaa caccaccttc ttcgaccccg ccggaggagg agaccccatt ctataccaac 6601 acctattctg atttttcggt caccctgaag tttatattct tatcctacca ggcttcggaa 6661 taatctccca tattgtaact tactactccg gaaaaaaaga accatttgga tacataggta 6721 tggtctgagc tatgatatca attggcttcc tagggtttat cgtgtgagca caccatatat 6781 ttacagtagg aatagacgta gacacacgag catatttcac ctccgctacc ataatcatcg 6841 ctatccccac cggcgtcaaa gtatttagct gactcgccac actccacgga agcaatatga 6901 aatgatctgc tgcagtgctc tgagccctag gattcatctt tcttttcacc gtaggtggcc 6961 tgactggcat tgtattagca aactcatcac tagacatcgt actacacgac acgtactacg 7021 ttgtagctca cttccactat gtcctatcaa taggagctgt atttgccatc ataggaggct 7081 tcattcactg atttccccta ttctcaggct acaccctaga ccaaacctac gccaaaatcc 7141 atttcactat catattcatc ggcgtaaatc taactttctt cccacaacac tttctcggcc 7201 tatccggaat gccccgacgt tactcggact accccgatgc atacaccaca tgaaacatcc 7261 tatcatctgt aggctcattc atttctctaa cagcagtaat attaataatt ttcatgattt 7321 gagaagcctt cgcttcgaag cgaaaagtcc taatagtaga agaaccctcc ataaacctgg 7381 agtgactata tggatgcccc ccaccctacc acacattcga agaacccgta tacataaaat 7441 ctagacaaaa aaggaaggaa tcgaaccccc caaagctggt ttcaagccaa ccccatggcc 7501 tccatgactt tttcaaaaag gtattagaaa aaccatttca taactttgtc aaagttaaat 7561 tataggctaa atcctatata tcttaatggc acatgcagcg caagtaggtc tacaagacgc 7621 tacttcccct atcatagaag agcttatcac ctttcatgat cacgccctca taatcatttt 7681 ccttatctgc ttcctagtcc tgtatgccct tttcctaaca ctcacaacaa aactaactaa 7741 tactaacatc tcagacgctc aggaaataga aaccgtctga actatcctgc ccgccatcat 7801 cctagtcctc atcgccctcc catccctacg catcctttac ataacagacg aggtcaacga 7861 tccctccctt accatcaaat caattggcca ccaatggtac tgaacctacg agtacaccga 7921 ctacggcgga ctaatcttca actcctacat acttccccca ttattcctag aaccaggcga 7981 cctgcgactc cttgacgttg acaatcgagt agtactcccg attgaagccc ccattcgtat 8041 aataattaca tcacaagacg tcttgcactc atgagctgtc cccacattag gcttaaaaac 8101 agatgcaatt cccggacgtc taaaccaaac cactttcacc gctacacgac cgggggtata 8161 ctacggtcaa tgctctgaaa tctgtggagc aaaccacagt ttcatgccca tcgtcctaga 8221 attaattccc ctaaaaatct ttgaaatagg gcccgtattt accctataac accccctcta 8281 ccccccccta gagcccactg taaagctaac ttagcattaa ccttttaagt taaagattaa 8341 gagaaccaac acctctttac agtgaaatgc cccaactaaa tactaccgta tggcccacca 8401 taattacccc catactcctt acactattcc tcatcaccca actaaaaata ttaaacacaa 8461 actaccacct acctccctca ccaaagccca taaaaataaa aaattataac aaaccctgag 8521 aaccaaaatg aacgaaaatc tgttcgcttc attcattacc cccacaatcc taggcctacc 8581 cgccgcagta ctgatcattc tatttccccc tctattgatc cccacctcca aatatctcat 8641 caacaaccga ctaatcacca cccaacaatg actaatcaaa ctaacctcaa aacaaatgat 8701 aaccatacac aacactaaag gacgaacctg atctcttata ctagtatcct taatcatttt 8761 tattgccaca actaacctcc tcggactcct gcctcactca tttacaccaa ccacccaact 8821 atctataaac ctagccatgg ccatcccctt atgagcgggc gcagtgatta taggctttcg 8881 ctctaagatt aaaaatgccc tagcccactt cttaccacaa ggcacaccta caccccttat 8941 ccccatacta gttattatcg aaaccatcag cctactcatt caaccaatag ccctggccgt 9001 acgcctaacc gctaacatta ctgcaggcca cctactcatg cacctaattg gaagcgccac 9061 cctagcaata tcaaccatta accttccctc tacacttatc atcttcacaa ttctaattct 9121 actgactatc ctagaaatcg ctgtcgcctt aatccaagcc tacgttttca cacttctagt 9181 aagcctctac ctgcacgaca acacataatg acccaccaat cacatgccta tcatatagta 9241 aaacccagcc catgacccct aacaggggcc ctctcagccc tcctaatgac ctccggccta 9301 gccatgtgat ttcacttcca ctccataacg ctcctcatac taggcctact aaccaacaca 9361 ctaaccatat accaatgatg gcgcgatgta acacgagaaa gcacatacca aggccaccac 9421 acaccacctg tccaaaaagg ccttcgatac gggataatcc tatttattac ctcagaagtt 9481 tttttcttcg caggattttt ctgagccttt taccactcca gcctagcccc taccccccaa 9541 ttaggagggc actggccccc aacaggcatc accccgctaa atcccctaga agtcccactc 9601 ctaaacacat ccgtattact cgcatcagga gtatcaatca cctgagctca ccatagtcta 9661 atagaaaaca accgaaacca aataattcaa gcactgctta ttacaatttt actgggtctc 9721 tattttaccc tcctacaagc ctcagagtac ttcgagtctc ccttcaccat ttccgacggc 9781 atctacggct caacattttt tgtagccaca ggcttccacg gacttcacgt cattattggc 9841 tcaactttcc tcactatctg cttcatccgc caactaatat ttcactttac atccaaacat 9901 cactttggct tcgaagccgc cgcctgatac tggcattttg tagatgtggt ttgactattt 9961 ctgtatgtct ccatctattg atgagggtct tactctttta gtataaatag taccgttaac 10021 ttccaattaa ctagttttga caacattcaa aaaagagtaa taaacttcgc cttaatttta 10081 ataatcaaca ccctcctagc cttactacta ataattatta cattttgact accacaactc 10141 aacggctaca tagaaaaatc caccccttac gagtgcggct tcgaccctat atcccccgcc 10201 cgcgtccctt tctccataaa attcttctta gtagctatta ccttcttatt atttgatcta 10261 gaaattgccc tccttttacc cctaccatga gccctacaaa caactaacct gccactaata 10321 gttatgtcat ccctcttatt aatcatcatc ctagccctaa gtctggccta tgagtgacta 10381 caaaaaggat tagactgagc cgaattggta tatagtttaa acaaaacgaa tgatttcgac 10441 tcattaaatt atgataatca tatttaccaa atgcccctca tttacataaa tattatacta 10501 gcatttacca tctcacttct aggaatacta gtatatcgct cacacctcat atcctcccta 10561 ctatgcctag aaggaataat actatcgctg ttcattatag ctactctcat aaccctcaac 10621 acccactccc tcttagccaa tattgtgcct attgccatac tagtctttgc cgcctgcgaa 10681 gcagcggtgg gcctagccct actagtctca atctccaaca catatggcct agactacgta 10741 cataacctaa acctactcca atgctaaaac taatcgtccc aacaattata ttactaccac 10801 tgacatgact ttccaaaaaa cacataattt gaatcaacac aaccacccac agcctaatta 10861 ttagcatcat ccctctacta ttttttaacc aaatcaacaa caacctattt agctgttccc 10921 caaccttttc ctccgacccc ctaacaaccc ccctcctaat actaactacc tgactcctac 10981 ccctcacaat catggcaagc caacgccact tatccagtga accactatca cgaaaaaaac 11041 tctacctctc tatactaatc tccctacaaa tctccttaat tataacattc acagccacag 11101 aactaatcat attttatatc ttcttcgaaa ccacacttat ccccaccttg gctatcatca 11161 cccgatgagg caaccagcca gaacgcctga acgcaggcac atacttccta ttctacaccc 11221 tagtaggctc ccttccccta ctcatcgcac tgatttacac tcacaacacc ctaggctcac 11281 taaacattct actactcact ctcactgccc aagaactatc aaactcctga gccaacaact 11341 taatatgact agcttacaca atagctttta tagtaaagat acctctttac ggactccact 11401 tatgactccc taaagcccat gtcgaagccc ccatcgctgg gtcaatagta cttgccgcag 11461 tactcttaaa actaggcggc tatggtataa tacgcctcac actcattctc aaccccctga 11521 caaaacacat agcctacccc ttccttgtac tatccctatg aggcataatt ataacaagct 11581 ccatctgcct acgacaaaca gacctaaaat cgctcattgc atactcttca atcagccaca 11641 tagccctcgt agtaacagcc attctcatcc aaaccccctg aagcttcacc ggcgcagtca 11701 ttctcataat cgcccacgga cttacatcct cattactatt ctgcctagca aactcaaact 11761 acgaacgcac tcacagtcgc atcataatcc tctctcaagg acttcaaact ctactcccac 11821 taatagcttt ttgatgactt ctagcaagcc tcgctaacct cgccttaccc cccactatta 11881 acctactggg agaactctct gtgctagtaa ccacgttctc ctgatcaaat atcactctcc 11941 tacttacagg actcaacata ctagtcacag ccctatactc cctctacata tttaccacaa 12001 cacaatgggg ctcactcacc caccacatta acaacataaa accctcattc acacgagaaa 12061 acaccctcat gttcatacac ctatccccca ttctcctcct atccctcaac cccgacatca 12121 ttaccgggtt ttcctcttgt aaatatagtt taaccaaaac atcagattgt gaatctgaca 12181 acagaggctt acgacccctt atttaccgag aaagctcaca agaactgcta actcatgccc 12241 ccatgtctaa caacatggct ttctcaactt ttaaaggata acagctatcc attggtctta 12301 ggccccaaaa attttggtgc aactccaaat aaaagtaata accatgcaca ctactataac 12361 caccctaacc ctgacttccc taattccccc catccttacc accctcgtta accctaacaa 12421 aaaaaactca tacccccatt atgtaaaatc cattgtcgca tccaccttta ttatcagtct 12481 cttccccaca acaatattca tgtgcctaga ccaagaagtt attatctcga actgacactg 12541 agccacaacc caaacaaccc agctctccct aagcttcaaa ctagactact tctccataat 12601 attcatccct gtggcattgt tcgttacatg gtccatcata gaattctcac tgtgatatat 12661 aaactcagac ccaaacatta atcagttctt caaatatcta ctcatcttcc taattaccat 12721 actaatctta gttaccgcta acaacctatt ccaactgttc atcggctgag agggcgtagg 12781 aattatatcc ttcttgctca tcagttgatg atacgcccga gcagatgcca acacagcagc 12841 cattcaagca atcctataca accgtatcgg cgatatcggt ttcatcctcg ccttagcatg 12901 atttatccta cactccaact catgagaccc acaacaaata gcccttctaa acgctaatcc 12961 aagcctcacc ccactactag gcctcctcct agcagcagca ggcaaatcag cccaattagg 13021 tctccacccc tgactcccct cagccataga aggccccacc ccagtctcag ccctactcca 13081 ctcaagcact atagttgtag caggaatctt cttactcatc cgcttccacc ccctagcaga 13141 aaatagccca ctaatccaaa ctctaacact atgcttaggc gctatcacca ctctgttcgc 13201 agcagtctgc gcccttacac aaaatgacat caaaaaaatc gtagccttct ccacttcaag 13261 tcaactagga ctcataatag ttacaatcgg catcaaccaa ccacacctag cattcctgca 13321 catctgtacc cacgccttct tcaaagccat actatttatg tgctccgggt ccatcatcca 13381 caaccttaac aatgaacaag atattcgaaa aataggagga ctactcaaaa ccatacctct 13441 cacttcaacc tccctcacca ttggcagcct agcattagca ggaatacctt tcctcacagg 13501 tttctactcc aaagaccaca tcatcgaaac cgcaaacata tcatacacaa acgcctgagc 13561 cctatctatt actctcatcg ctacctccct gacaagcgcc tatagcactc gaataattct 13621 tctcacccta acaggtcaac ctcgcttccc cacccttact aacattaacg aaaataaccc 13681 caccctacta aaccccatta aacgcctgac agccggaagc ctattcgcag gatttctcat 13741 tactaacaac atttcccccg catccccctt ccaaacaaca atccccctct acctaaaact 13801 cacagccctc gctgtcactt tcctaggact tctaacagcc ctagacctca actacctaac 13861 caacaaactt aaaataaaac ccccactatg cacattttat ttctccaaca tactcggatt 13921 ctaccctagc atcacacacc gcacaatccc ctatctaggc cttcttacga gccaaaacct 13981 gcccctactc ctcctagacc taacctgact agaaaagcta ttacctaaaa caatttcaca 14041 gcaccaaatc tccacctcca tcatcacctc aacccaaaaa ggcataatta aactttactt 14101 cctctctttc ttcttcccac tcatcctaac cctactccta atcacataac ctattccccc 14161 gagcaatctc aattacaata tatacaccaa caaacaatgt tcaaccagta actactacta 14221 atcaacgccc ataatcatac aaagcccccg caccaatagg atcctcccga atcaaccctg 14281 acccctctcc ttcataaatt attcagcttc ctacactatt aaagtttacc acaaccacca 14341 ccccatcata ctctttcacc cacagcacca atcctacctc catcgctaac cccactaaaa 14401 cactcaccaa gacctcaacc cctgaccccc atgcctcagg atactcctca atagccatcg 14461 ctgtagtata tccaaagaca accatcattc cccctaaata aattaaaaaa actattaaac 14521 ccatataacc tcccccaaaa ttcagaataa taacacaccc gaccacaccg ctaacaatca 14581 atactaaacc cccataaata ggagaaggct tagaagaaaa ccccacaaac cccattacta 14641 aacccacact caacagaaac aaagcataca tcattattct cgcacggact acaaccacga 14701 ccaatgatat gaaaaaccat cgttgtattt caactacaag aacaccaatg accccaatac 14761 gcaaaattaa ccccctaata aaattaatta accactcatt catcgacctc cccaccccat 14821 ccaacatctc cgcatgatga aacttcggct cactccttgg cgcctgcctg atcctccaaa 14881 tcaccacagg actattccta gccatgcact actcaccaga cgcctcaacc gccttttcat 14941 caatcgccca catcactcga gacgtaaatt atggctgaat catccgctac cttcacgcca 15001 atggcgcctc aatattcttt atctgcctct tcctacacat cgggcgaggc ctatattacg 15061 gatcattcct ctactcagaa acctgaaaca tcggcattat cctcctgctt gcaactatag 15121 caacagcctt cataggctat gtcctcccgt gaggccaaat atcattctga ggggccacag 15181 taattacaaa cttactatcc gccatcccat acattgggac agacctagtt caatgaatct 15241 gaggaggcta ctcagtagac agtcccaccc tcacacgatt ctttaccttt cacttcatct 15301 tgcccttcat tattgcagcc ctagcagcac tccacctcct attcttgcac gaaacgggat 15361 caaacaaccc cctaggaatc acctcccatt ccgataaaat caccttccac ccttactaca 15421 caatcaaaga cgccctcggc ttacttctct tcattctctc cttaatgaca ttaacactat 15481 tctcaccaga cctcctaggc gacccagaca attataccct agccaacccc ttaaacaccc 15541 ctccccacat caagcccgaa tgatatttcc tattcgccta cacaattctc cgatccgtcc 15601 ctaacaaact aggaggcgtc cttgccctat tactatccat cctcatccta gcaataatcc 15661 ccatcctcca tatatccaaa caacaaagca taatatttcg cccactaagc caatcacttt 15721 attgactcct agccgcagac ctcctcattc taacctgaat cggaggacaa ccagtaagct 15781 acccttttac catcattgga caagtagcat ccgtactata cttcacaaca atcctaatcc 15841 taataccaac tatctcccta attgaaaaca aaatactcaa atgggcctgt ccttgtagta 15901 taaactaata caccagtctt gtaaaccgga gatgaaaacc tttttccaag gacaaatcag 15961 agaaaaagtc tttaactcca ccattagcac ccaaagctaa gattctaatt taaactattc 16021 tctgttcttt catggggaag cagatttggg taccacccaa gtattgactt acccatcaac 16081 aaccgctatg tatttcgtac attactgcca gccaccatga atattgcacg gtaccataaa 16141 tacttaacca cctgtagtac ataaaaaccc aacccacatc aaaaccccct ccccatgctt 16201 acaagcaagt acagcaatca actctcaact atcacacatc aactgcagct ccaaagccac 16261 ctctcaccca ctagaatacc aacaaaccta cccaccctta acagtacata gtacataaag 16321 ccatttaccg tacatagcac attacagtca aatcccttct cgtccccatg gatgaccccc 16381 ctcagatagg ggtcccttga ccaccatcct ccgtgaaatc aatatcccgc acaagagtgc 16441 tactctcctc gctccgggcc cataacactt gggggtagct aaagtgaact gtatccgaca 16501 tctggttcct acttcagggc cataaagcct aaatagccca cacgttcccc ttaaataaga 16561 catcacgatg //