LOCUS AY195786 16565 bp DNA circular PRI 10-JUN-2004 DEFINITION Homo sapiens haplotype Na5A mitochondrion, complete genome. ACCESSION AY195786 VERSION AY195786.2 GI:48596214 KEYWORDS . SOURCE mitochondrion Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 16565) AUTHORS Mishmar,D., Ruiz-Pesini,E., Golik,P., Macaulay,V., Clark,A.G., Hosseini,S., Brandon,M., Easley,K., Chen,E., Brown,M.D., Sukernik,R.I., Olckers,A. and Wallace,D.C. TITLE Natural selection shaped regional mtDNA variation in humans JOURNAL Proc. Natl. Acad. Sci. U.S.A. 100 (1), 171-176 (2003) MEDLINE 22406325 PUBMED 12509511 REFERENCE 2 (bases 1 to 16565) AUTHORS Mishmar,D., Ruiz-Pesini,E., Golik,P., Macaulay,V., Clark,A.G., Hosseini,S., Brandon,M., Easley,K., Chen,E., Brown,M.D., Sukernik,R.I., Olckers,A. and Wallace,D.C. TITLE Direct Submission JOURNAL Submitted (11-DEC-2002) MAMMAG, University of California, Irvine, 2nd Floor Hewitt Hall, Irvine, California 92697-3940, USA REFERENCE 3 (bases 1 to 16565) AUTHORS Mishmar,D., Ruiz-Pesini,E., Golik,P., Macaulay,V., Clark,A.G., Hosseini,S., Brandon,M., Easley,K., Chen,E., Brown,M.D., Sukernik,R.I., Olckers,A. and Wallace,D.C. TITLE Direct Submission JOURNAL Submitted (10-JUN-2004) MAMMAG, University of California, Irvine, 2nd Floor Hewitt Hall, Irvine, California 92697-3940, USA REMARK Sequence update by submitter COMMENT On Jun 10, 2004 this sequence version replaced gi:29690966. FEATURES Location/Qualifiers source 1..16565 /organism="Homo sapiens" /organelle="mitochondrion" /mol_type="genomic DNA" /isolation_source="Native American" /isolation_source="A haplogroup Native American" /db_xref="taxon:9606" /haplotype="Na5A" D-loop complement(join(16100..16565,1..191)) tRNA 575..645 /product="tRNA-Phe" rRNA 646..1599 /product="12S ribosomal RNA" tRNA 1600..1668 /product="tRNA-Val" rRNA 1669..3226 /product="16S ribosomal RNA" tRNA 3227..3301 /product="tRNA-Leu" gene 3304..4260 /gene="ND1" CDS 3304..4260 /gene="ND1" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 1" /protein_id="AAO88813.1" /db_xref="GI:29690967" /translation="MPMANLLLLIVPILIAMAFLMLTERKILGYMQLRKGPNVVGPYG LLQPFADAMKLFTKEPLKPATSTITLYITAPTLALTIALLLWTPLPMPNPLVNLNLGL LFILATSSLAVYSILWSGWASNSNYALIGALRAVAQTISYEVTLAIILLSTLLMSGSF NLSTLITTQEHLWLLLPSWPLAMMWFISTLAETNRTPFDLAEGESELVSGFNIEYAAG PFALFFMAEYTNIIMMNTLTTTIFLGTTYDALSPELYTTYFVTKTLLLTSLFLWIRTA YPRFRYDQLMHLLWKNFLPLTLALLMWYVSMPITISSIPPQT" tRNA 4260..4328 /product="tRNA-Ile" tRNA complement(4326..4397) /product="tRNA-Gln" tRNA 4399..4466 /product="tRNA-Met" gene 4467..5510 /gene="ND2" CDS 4467..5510 /gene="ND2" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 2" /protein_id="AAO88814.1" /db_xref="GI:29690968" /translation="MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVL TKKMNPRSTEAAIKYFLTQATASMILLMAILFNNMLSGQWTMTNTTNQYSSLMIMMAM AMKLGMAPFHFWVPEVAQGTPLTSGLLLLTWQKLAPISIMYQISPSLNVSLLLTLSIL SIMAGSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLL LNLNSSTTTLLLSRTWNKLTWLTPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSL IIPTIMATITLLNLYFYLRLIYSTSITLLPMSNNVKMKWQFEHTKPTPFLPTLIALTT LLLPISPFMLMIL" tRNA 5509..5576 /product="tRNA-Trp" tRNA complement(5584..5652) /product="tRNA-Ala" tRNA complement(5654..5726) /product="tRNA-Asn" tRNA complement(5758..5823) /product="tRNA-Cys" tRNA complement(5823..5888) /product="tRNA-Tyr" gene 5901..7442 /gene="COX1" CDS 5901..7442 /gene="COX1" /codon_start=1 /transl_table=2 /product="cytochrome oxidase subunit I" /protein_id="AAO88815.1" /db_xref="GI:29690969" /translation="MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQP GNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSF WLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILG AINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTT FFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWA MMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKW SAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGG FIHWFPLFSGYTLDQTYAKIHFTIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTW NILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEEP VYMKS" tRNA complement(7442..7513) /product="tRNA-Ser" tRNA 7515..7582 /product="tRNA-Asp" gene 7583..8266 /gene="COX2" CDS 7583..8266 /gene="COX2" /codon_start=1 /transl_table=2 /product="cytochrome oxidase subunit II" /protein_id="AAO88816.1" /db_xref="GI:29690970" /translation="MAHAAQVGLQDATSPIMEELITFHDHALMIIFLICFLVLYALFL TLTTKLTNTNISDAQEMETVWTILPAIILVLIALPSLRILYMTDEVNDPSLTIKSIGH QWYWTYEYTDYGGLIFNSYMLPPLFLEPGDLRLLDVDNRVVLPIETPIRMMITSQDVL HSWAVPTLGLKTDAIPGRLNQTTFTATRPGVYYGQCSEICGANHSFMPIVLELIPLKI FEMGPVFTL" tRNA 8291..8360 /product="tRNA-Lys" gene 8362..8568 /gene="ATP8" CDS 8362..8568 /gene="ATP8" /codon_start=1 /transl_table=2 /product="ATP synthase F0 subunit 8" /protein_id="AAO88817.1" /db_xref="GI:29690971" /translation="MPQLNTTVWPTMITPMLLTLFLITQLKMLNTNYHLPPSPKPMKM KNYNKPWEPKWTKICSLHSLPPQS" gene 8523..9203 /gene="ATP6" CDS 8523..9203 /gene="ATP6" /codon_start=1 /transl_table=2 /product="ATP synthase F0 subunit 6" /protein_id="AAO88818.1" /db_xref="GI:29690972" /translation="MNENLFASFIAPTILGLPAAVLIILFPPLLIPTSKYLINNRLIT TQQWLIKLTSKQMMTMHNTKGRTWSLMLVSLIIFIATTNLLGLLPYSFTPTTQLSMNL AMAIPLWAGAVIMGFRSKIKNALAHFLPQGTPTPLIPMLVIIETISLLIQPMALAVRL TANITAGHLLMHLIGSATLAMSTINLPSTLIIFTILILLTILEIAVALIQAYVFTLLV SLYLHDNT" gene 9203..9983 /gene="COX3" CDS 9203..9983 /gene="COX3" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:9983,aa:TERM) /transl_table=2 /product="cytochrome oxidase subunit III" /protein_id="AAO88819.1" /db_xref="GI:29690973" /translation="MTHQSHAYHMVKPSPWPLTGALSALLMTSGLAMWFHFHSMTLLM LGLLTNTLTMYQWWRDVTRESTYQGHHTPPVQKGLRYGMILFITSEVFFFAGFFWAFY HSSLAPTPQLGGHWPPTGITPLNPLEVPLLNTSVLLASGVSITWAHHSLMENNRNQMI QALLITILLGLYFTLLQASEYFESPFTISDGIYGSTFFVATGFHGLHVIIGSTFLTIC FIRQLMFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIYWWG" tRNA 9987..10054 /product="tRNA-Gly" gene 10055..10400 /gene="ND3" CDS 10055..10400 /gene="ND3" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:10400,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 3" /protein_id="AAO88820.1" /db_xref="GI:29690974" /translation="MNFALILMINTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPM SPARVPFSMKFFLVAITFLLFDLEIALLLPLPWALQTTNLPLMVMSSLLLIIILALSL AYEWLQKGLDWTE" tRNA 10401..10465 /product="tRNA-Arg" gene 10466..10762 /gene="ND4L" CDS 10466..10762 /gene="ND4L" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 4L" /protein_id="AAO88821.1" /db_xref="GI:29690975" /translation="MPLIYMNIMLAFTISLLGMLVYRSHLMSSLLCLEGMMLSLFIMA TLMTLNTHSLLANIVPIAMLVFAACEAAVGLALLVSISNTYGLDYVHNLNLLQC" gene 10756..12133 /gene="ND4" CDS 10756..12133 /gene="ND4" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:12133,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 4" /protein_id="AAO88822.1" /db_xref="GI:29690976" /translation="MLKLIVPTIMLLPLTWLSKKHMIWINTTTHSLIISIIPLLFFNQ INNNLFSCSPTFSSDPLTTPLLMLTTWLLPLTIMASQRHLSSEPLSRKKLYLSMLISL QISLIMTFTATELIMFYIFFETTLIPTLAIITRWGNQPERLNAGTYFLFYTLVGSLPL LIALIYTHNTLGSLNILLLTLTAQELSNSWANNLMWLAYTMAFMVKMPLYGLHLWLPK AHVEAPIAGSMVLAAVLLKLGGYGMMRLTLILNPLTKHMAYPFLVLSLWGMIMTSSIC LRQTDLKSLIAYSSISHMALVVTAILIQTPWSFTGAVILMIAHGLTSSLLFCLANSNY ERTHSRIMILSQGLQTLLPLMAFWWLLASLANLALPPTINLLGELSVLVTTFSWSNIT LLLTGLNMLVTALYSLYMFTTTQWGSLTHHINNMKPSFTRENTLMFMHLSPILLLSLN PDIITGFSS" tRNA 12134..12202 /product="tRNA-His" tRNA 12203..12261 /product="tRNA-Ser" tRNA 12262..12332 /product="tRNA-Leu" gene 12333..14144 /gene="ND5" CDS 12333..14144 /gene="ND5" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 5" /protein_id="AAO88823.1" /db_xref="GI:29690977" /translation="MTMHTTMTTLTLTSLIPPILTTLVNPNKKNSYPHYVKSIVASTF IISLFPTTMFMCLDQEVIISNWHWATTQTTQLSLSFKLDYFSMMFIPVALFVTWSIME FSLWYMNSDPNINQFFKYLLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLISWWYA RADANTAAIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLNANPSLTPLLGLLL AAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFHPLAENSPLIQTL TLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAF FKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSK DHIIETANMSYTNAWALSITLIATSLTSAYSTRMILLTLTGQPRFPTLTNINENNPTL LNPIKRLAAGSLFAGFLITNNISPASPFQTTIPLYLKLTALAVTFLGLLTALDLNYLT NKLKMKSPLCTFYFSNMLGFYPSITHRTIPYLGLLTSQNLPLLLLDLTWLEKLLPKTI SQHQISTSIITSTQKGMIKLYFLSFFFPLILTLLLIT" gene complement(14145..14669) /gene="ND6" CDS complement(14145..14669) /gene="ND6" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 6" /protein_id="AAO88824.1" /db_xref="GI:29690978" /translation="MMYALFLLSVGLVMGFVGFSSKPSPIYGGLVLIVSGVVGCVIIL NFGGGYMGLMVFLIYLGGMMVVFGYTTAMAIEEYPEAWGSGVEVLVSVLVGLAMEVGL VLWVKEYDGVVVVVNFNSVGSWMIYEGEGSGLIREDPIGAGALYDYGRWLVVVTGWTL FVGVYIVIEIARGN" tRNA complement(14670..14738) /product="tRNA-Glu" gene 14743..15877 /gene="cytb" CDS 14743..15877 /gene="cytb" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:15877,aa:TERM) /transl_table=2 /product="cytochrome b" /protein_id="AAO88825.1" /db_xref="GI:29690979" /translation="MTPMRKINPLMKLINHSFIDLPTPSNISAWWNFGSLLGACLILQ ITTGLFLAMHYSPDASTAFSSIAHITRDVNYGWIIRYLHANGASMFFICLFLHIGRGL YYGSFLYSETWNIGIILLLATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDL VQWIWGGYSVDSPTLTRFFTFHFILPFIIAALAALHLLFLHETGSNNPLGITSHSDKI TFHPYYTIKDALGLLLFLLSLMTLTLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLF AYTILRSVPNKLGGVLALLLSILILAMIPILHMSKQQSMMFRPLSQSLYWLLAADLLI LTWIGGQPVSYPFTIIGQVASVLYFTTILILMPTISLIENKMLK" tRNA 15884..15949 /product="tRNA-Thr" tRNA complement(15951..16019) /product="tRNA-Pro" ORIGIN 1 gatcacaggt ctatcaccct attaaccact cacgggagct ctccatgcat ttggtatttt 61 cgtttggggg gtgtgcacgc gatagcattg cgagacgctg gagccggagc accctatgtc 121 gcagtatctg tctttgattc ctgccccatc ctgttattta tcgcacctac gttcaatatt 181 acaggcgaac atacttacta aagtgtgtta attaattaat gcttgtagga catagtaata 241 acaattgaat gtctgcacag ccgctttcca cacagacatc ataacaaaaa atttccacca 301 aaccccccct cccccgcttc tggccacagc acttaaacac atctctgcca aaccccaaaa 361 acaaagaacc ctaacaccag cctaaccaga tttcaaattt tatcttttgg cggtatgcac 421 ttttaacagt caccccccaa ctaacacatt attttcccct cccactccca tactactaat 481 ctcatcaata caacccccgc ccatcctacc cagcacacac accgctgcta accccatacc 541 ccgaaccaac caaaccccaa agacaccccc cacagtttat gtagcttacc tcctcaaagc 601 aatacactga aaatgtttag acgggctcac atcaccccat aaacaaatag gtttggtcct 661 ggcctttcta ttagctctta gtaagattac acatgcaagc atccccgttc cagtgagttc 721 accctctaaa tcaccacgat caaaagggac aagcatcaag cacgcagcaa tgcagctcaa 781 aacgcttagc ctagccacac ccccacggga aacagcagtg attaaccttt agcaataaac 841 gaaagtttaa ctaagctata ctaaccccag ggttggtcaa tttcgtgcca gccaccgcgg 901 tcacacgatt aacccaagtc aatagaagcc ggcgtaaaga gtgttttaga tcaccccctc 961 cccaataaag ctaaaactca cctgagttgt aaaaaactcc agttgacaca aaatagacta 1021 cgaaagtggc tttaacatat ctgaacacac aatagctaag acccaaactg ggattagata 1081 ccccactatg cttagcccta aacctcaaca gttaaatcaa caaaactgct cgccagaaca 1141 ctacgagcca cagcttaaaa ctcaaaggac ctggcggtgc ttcatatccc tctagaggag 1201 cctgttctgt aatcgataaa ccccgatcaa cctcaccacc tcttgctcag cctatatacc 1261 gccatcttca gcaaaccctg atgaaggcta caaagtaagc gcaagtaccc acgtaaagac 1321 gttaggtcaa ggtgtagccc atgaggtggc aagaaatggg ctacattttc taccccagaa 1381 aactacgata gcccttatga aacttaaggg tcgaaggtgg atttagcagt aaactgagag 1441 tagagtgctt agttgaacag ggccctgaag cgcgtacaca ccgcccgtca ccctcctcaa 1501 gtatacttca aaggacattt aactaaaacc cctacgcatt tatatagagg agacaagtcg 1561 taacatggta agtgtactgg aaagtgcact tggacgaacc agagtgtagc ttaacacaaa 1621 gcacccaact tacacttagg agatttcaac ttaacttgac cgctctgagc taaacctagc 1681 cccaaaccca ctccacctta ctaccagaca accttagcca aaccatttac ccagataaag 1741 tataggcgat agaaattgaa acctggcgca atagatatag taccgcaagg gaaagatgaa 1801 aaattataac caagcataat atagcaagga ctaaccccta taccttctgc ataatgaatt 1861 aactagaaat aactttgcaa ggagagccaa agctaagacc cccgaaacca gacgagctac 1921 ctaagaacag ctaaaagagc acacccgtct atgtagcaaa atagtgggaa gatttatagg 1981 tagaggcgac aaacctaccg agcctggtga tagctggttg tccaagatag aatcttagtt 2041 caactttaaa tttgcccaca gaaccctcta aatccccttg taaatttaac tgttagtcca 2101 aagaggaaca gctctttgga cactaggaaa aaaccttgta gagagagtaa aaaatttaac 2161 acccatagta ggcctaaaag cagccaccaa ttaagaaagc gttcaagctc aacacccact 2221 acctaaaaaa tcccaaacat ataactgaac tcctcacacc caattggacc aatctatcac 2281 cctatagaag aactaatgtt agtataagta acatgaaaac attctcctcc gcataagcct 2341 gcgtcagatt aaaacactga actgacaatt aacagcccaa tatctacaat caaccaacaa 2401 gtcattatta ccctcactgt caacccaaca caggcatgct cataaggaaa ggttaaaaaa 2461 agtaaaagga actcggcaaa tcttaccccg cctgtttacc aaaaacatca cctctagcat 2521 caccagtatt agaggcaccg cctgcccagt gacacatgtt taacggccgc ggtaccctaa 2581 ccgtgcaaag gtagcataat cacttgttcc ttaaataggg acctgtatga atggctccac 2641 gagggttcag ctgtctctta cttttaacca gtgaaattga cctgcccgtg aagaggcggg 2701 catgacacag caagacgaga agaccctatg gagctttaat ttattaatgc aaacagtacc 2761 taacaaaccc acaggtccta aactaccaaa cctgcattaa aaatttcggt tggggcgacc 2821 tcggagcaga acccaacctc cgagcagtac atgctaagac ttcaccagtc aaagcgaact 2881 actatactca attgatccaa taacttgacc aacggaacaa gttaccctag ggataacagc 2941 gcaatcctat tctagagtcc atatcaacaa tagggtttac gacctcgatg ttggatcagg 3001 acatcccgat ggtgcagccg ctattaaagg ttcgtttgtt caacgattaa agtcctacgt 3061 gatctgagtt cagaccggag taatccaggt cggtttctat ctacttcaaa ttcctccctg 3121 tacgaaagga caagagaaat aaggcctact tcacaaagcg ccttcccccg taaatgatat 3181 catctcaact tagtattata cccacaccca cccaagaaca gggtttgtta agatggcaga 3241 gcccggtaat cgcataaaac ttaaaacttt acagtcagag gttcaattcc tcttcttaac 3301 aacataccca tggccaacct cctactcctc attgtaccca ttctaatcgc aatggcattc 3361 ctaatgctta ccgaacgaaa aattctaggc tatatacaac tacgcaaagg ccccaacgtt 3421 gtaggcccct acgggctact acaacccttc gctgacgcca taaaactctt caccaaagag 3481 cccctaaaac ccgccacatc taccatcacc ctctacatca ccgccccgac cttagctctc 3541 accatcgctc ttctactatg aacccccctc cccataccca accccctggt caacctcaac 3601 ctaggcctcc tatttattct agccacctct agcctagccg tttactcaat cctctgatca 3661 gggtgagcat caaactcaaa ctacgccctg atcggcgcac tgcgagcagt agcccaaaca 3721 atctcatatg aagtcaccct agccatcatt ctactatcaa cattactaat aagtggctcc 3781 tttaacctct ccacccttat cacaacacaa gaacacctct gattactcct gccatcatga 3841 cccttggcca taatatgatt tatctccaca ctagcagaga ccaaccgaac ccccttcgac 3901 cttgccgaag gggagtccga actagtctca ggcttcaaca tcgaatacgc cgcaggcccc 3961 ttcgccctat tcttcatagc cgaatacaca aacattatta taataaacac cctcaccact 4021 acaatcttcc taggaacaac atatgacgca ctctcccctg aactctacac aacatatttt 4081 gtcaccaaga ccctacttct aacctccctg ttcttatgaa ttcgaacagc atacccccga 4141 ttccgctacg accaactcat acacctccta tgaaaaaact tcctaccact caccctagca 4201 ttacttatat gatatgtctc catacccatt acaatctcca gcatcccccc tcaaacctaa 4261 gaaatatgtc tgataaaaga gttactttga tagagtaaat aataggagct taaaccccct 4321 tatttctagg actatgagaa tcgaacccat ccctgagaat ccaaaattct ccgtgccacc 4381 tatcacaccc catcctaaag taaggtcagc taaataagct atcgggccca taccccgaaa 4441 atgttggtta tacccttccc gtactaatta atcccctggc ccaacccgtc atctactcta 4501 ccatctttgc aggcacactc atcacagcgc taagctcgca ctgatttttt acctgagtag 4561 gcctagaaat aaacatgcta gcttttattc cagttctaac caaaaaaata aaccctcgtt 4621 ccacagaagc tgccatcaag tatttcctca cgcaagcaac cgcatccata atccttctaa 4681 tagctatcct cttcaacaat atactctccg gacaatgaac cataaccaat actaccaatc 4741 aatactcatc attaataatc ataatggcta tagcaataaa actaggaata gccccctttc 4801 acttctgagt cccagaggtt gcccaaggca cccctctgac atccggcctg cttcttctca 4861 catgacaaaa actagccccc atctcaatca tataccaaat ctctccctca ctaaacgtaa 4921 gccttctcct cactctctca atcttatcca tcatagcagg cagttgaggt ggattaaacc 4981 aaacccagct acgcaaaatc ttagcatact cctcaattac ccacatagga tgaataatag 5041 cagttctacc gtacaaccct aacataacca ttcttaattt aactatttat attatcctaa 5101 ctactaccgc attcctacta ctcaacttaa actccagcac cacgacccta ctactatctc 5161 gcacctgaaa caagctaaca tgactaacac ccttaattcc atccaccctc ctctccctag 5221 gaggcctgcc cccgctaacc ggctttttgc ccaaatgggc cattatcgaa gaattcacaa 5281 aaaacaatag cctcatcatc cccaccatca tagccaccat caccctcctt aacctctact 5341 tctacctacg cctaatctac tccacctcaa tcacactact ccccatatct aacaacgtaa 5401 aaataaaatg acagtttgaa catacaaaac ccaccccatt cctccccaca ctcatcgccc 5461 ttaccacgct actcctacct atctcccctt ttatactaat aatcttatag aaatttaggt 5521 taaatacaga ccaagagcct tcaaagccct cagtaagttg caatacttaa tttctgtaac 5581 agctaaggac tgcaaaaccc cactctgcat caactgaacg caaatcagcc actttaatta 5641 agctaagccc ttactagacc aatgggactt aaacccacaa acacttagtt aacagctaag 5701 caccctaatc aactggcttc aatctacttc tcccgccgcc gggaaaaaag gcgggagaag 5761 ccccggcagg tttgaagctg cttcttcgaa tttgcaattc aatatgaaaa tcacctcgga 5821 gctggtaaaa agaggcctaa cccctgtctt tagatttaca gtccaatgct tcactcagcc 5881 attttacctc acccccactg atgttcgccg accgttgact attctctaca aaccacaaag 5941 acattggaac actataccta ttattcggcg catgagctgg agtcctaggc acagctctaa 6001 gcctccttat tcgagccgag ctgggccagc caggcaacct tctaggtaac gaccacatct 6061 acaacgttat cgtcacagcc catgcatttg taataatctt cttcatagta atacccatca 6121 taatcggagg ctttggcaac tgactagttc ccctaataat cggtgccccc gatatggcgt 6181 ttccccgcat aaacaacata agcttctgac tcttacctcc ctctctccta ctcctgctcg 6241 catctgctat agtggaggcc ggagcaggaa caggttgaac agtctaccct cccttagcag 6301 ggaactactc ccaccctgga gcctccgtag acctaaccat cttctcctta cacctagcag 6361 gtgtctcctc tatcttaggg gccatcaatt tcatcacaac aattatcaat ataaaacccc 6421 ctgccataac ccaataccaa acgcccctct tcgtctgatc cgtcctaatc acagcagtcc 6481 tacttctact atctctccca gtcctagctg ctggcatcac tatactacta acagaccgca 6541 acctcaacac caccttcttc gaccccgccg gaggaggaga ccccattcta taccaacacc 6601 tattctgatt tttcggtcac cctgaagttt atattcttat cctaccaggc ttcggaataa 6661 tctcccatat tgtaacttac tactccggaa aaaaagaacc atttggatac ataggtatgg 6721 tctgagctat gatatcaatt ggcttcctag ggtttatcgt gtgagcacac catatattta 6781 cagtaggaat agacgtagac acacgagcat atttcacctc cgctaccata atcatcgcta 6841 tccccaccgg cgtcaaagta tttagctgac tcgccacact ccacggaagc aatatgaaat 6901 gatctgctgc agtgctctga gccctaggat tcatctttct tttcaccgta ggtggcctga 6961 ctggcattgt attagcaaac tcatcactag acatcgtact acacgacacg tactacgttg 7021 tagctcactt ccactatgtc ctatcaatag gagctgtatt tgccatcata ggaggcttca 7081 ttcactgatt tcccctattc tcaggctaca ccctagacca aacctacgcc aaaatccatt 7141 tcactatcat attcatcggc gtaaatctaa ctttcttccc acaacacttt ctcggcctat 7201 ccggaatgcc ccgacgttac tcggactacc ccgatgcata caccacatga aacatcctat 7261 catctgtagg ctcattcatt tctctaacag cagtaatatt aataattttc atgatttgag 7321 aagccttcgc ttcgaagcga aaagtcctaa tagtagaaga accctccata aacctggagt 7381 gactatatgg atgcccccca ccctaccaca cattcgaaga acccgtatac ataaaatcta 7441 gacaaaaaag gaaggaatcg aaccccccaa agctggtttc aagccaaccc catggcctcc 7501 atgacttttt caaaaaggta ttagaaaaac catttcataa ctttgtcaaa gttaaattat 7561 aggctaaatc ctatatatct taatggcaca tgcagcgcaa gtaggtctac aagacgctac 7621 ttcccctatc atagaagagc ttatcacctt tcatgatcac gccctcataa tcattttcct 7681 tatctgcttc ctagtcctgt atgccctttt cctaacactc acaacaaaac taactaatac 7741 taacatctca gacgctcagg aaatagaaac cgtctgaact atcctgcccg ccatcatcct 7801 agtcctcatc gccctcccat ccctacgcat cctttacata acagacgagg tcaacgatcc 7861 ctcccttacc atcaaatcaa ttggccacca atggtactga acctacgagt acaccgacta 7921 cggcggacta atcttcaact cctacatact tcccccatta ttcctagaac caggcgacct 7981 gcgactcctt gacgttgaca atcgagtagt actcccgatt gaaaccccca ttcgtataat 8041 aattacatca caagacgtct tgcactcatg agctgtcccc acattaggct taaaaacaga 8101 tgcaattccc ggacgtctaa accaaaccac tttcaccgct acacgaccgg gggtatacta 8161 cggtcaatgc tctgaaatct gtggagcaaa ccacagtttc atgcccatcg tcctagaatt 8221 aattccccta aaaatctttg aaatagggcc cgtatttacc ctatagcacc ccctctaccc 8281 ctctagagcc cactgtaaag ctaacttagc attaaccttt taagttaaag attaagagaa 8341 ccaacacctc tttacagtga aatgccccaa ctaaatacta ccgtatggcc caccataatt 8401 acccccatac tccttacact attcctcatc acccaactaa aaatattaaa cacaaactac 8461 cacctacctc cctcaccaaa gcccataaaa ataaaaaatt ataacaaacc ctgagaacca 8521 aaatgaacga aaatctgttc gcttcattca ttgcccccac aatcctaggc ctacccgccg 8581 cagtactgat cattctattt ccccctctat tgatccccac ctccaaatat ctcatcaaca 8641 accgactaat caccacccaa caatgactaa tcaaactaac ctcaaaacaa atgataacca 8701 tacacaacac taaaggacga acctgatctc ttatactagt atccttaatc atttttattg 8761 ccacaactaa cctcctcgga ctcctgcctt actcatttac accaaccacc caactatcta 8821 taaacctagc catggccatc cccttatgag cgggcgcagt gattataggc tttcgctcta 8881 agattaaaaa tgccctagcc cacttcttac cacaaggcac acctacaccc cttatcccca 8941 tactagttat tatcgaaacc atcagcctac tcattcaacc aatagccctg gccgtacgcc 9001 taaccgctaa cattactgca ggccacctac tcatgcacct aattggaagc gccaccctag 9061 caatatcaac cattaacctt ccctctacac ttatcatctt cacaattcta attctactga 9121 ctatcctaga aatcgctgtc gccttaatcc aagcctacgt tttcacactt ctagtaagcc 9181 tctacctgca cgacaacaca taatgaccca ccaatcacat gcctatcata tagtaaaacc 9241 cagcccatga cccctaacag gggccctctc agccctccta atgacctccg gcctagccat 9301 gtgatttcac ttccactcca taacgctcct catactaggc ctactaacca acacactaac 9361 catataccaa tgatggcgcg atgtaacacg agaaagcaca taccaaggcc accacacacc 9421 acctgtccaa aaaggccttc gatacgggat aatcctattt attacctcag aagttttttt 9481 cttcgcagga tttttctgag ccttttacca ctccagccta gcccctaccc cccaattagg 9541 agggcactgg cccccaacag gcatcacccc gctaaatccc ctagaagtcc cactcctaaa 9601 cacatccgta ttactcgcat caggagtatc aatcacctga gctcaccata gtctaataga 9661 aaacaaccga aaccaaataa ttcaagcact gcttattaca attttactgg gtctctattt 9721 taccctccta caagcctcag agtacttcga gtctcccttc accatttccg acggcatcta 9781 cggctcaaca ttttttgtag ccacaggctt ccacggactt cacgtcatta ttggctcaac 9841 tttcctcact atctgcttca tccgccaact aatatttcac tttacatcca aacatcactt 9901 tggcttcgaa gccgccgcct gatactggca ttttgtagat gtggtttgac tatttctgta 9961 tgtctccatc tattgatgag ggtcttactc ttttagtata aatagtaccg ttaacttcca 10021 attaactagt tttgacaaca ttcaaaaaag agtaataaac ttcgccttaa ttttaataat 10081 caacaccctc ctagccttac tactaataat tattacattt tgactaccac aactcaacgg 10141 ctacatagaa aaatccaccc cttacgagtg cggcttcgac cctatatccc ccgcccgcgt 10201 ccctttctcc ataaaattct tcttagtagc tattaccttc ttattatttg atctagaaat 10261 tgccctcctt ttacccctac catgagccct acaaacaact aacctgccac taatagttat 10321 gtcatccctc ttattaatca tcatcctagc cctaagtctg gcctatgagt gactacaaaa 10381 aggattagac tgaaccgaat tggtatatag tttaaacaaa acgaatgatt tcgactcatt 10441 aaattatgat aatcatattt accaaatgcc cctcatttac ataaatatta tactagcatt 10501 taccatctca cttctaggaa tactagtata tcgctcacac ctcatatcct ccctactatg 10561 cctagaagga ataatactat cgctgttcat tatagctact ctcataaccc tcaacaccca 10621 ctccctctta gccaatattg tgcctattgc catactagtc tttgccgcct gcgaagcagc 10681 ggtgggccta gccctactag tctcaatctc caacacatat ggcctagact acgtacataa 10741 cctaaaccta ctccaatgct aaaactaatc gtcccaacaa ttatattact accactgaca 10801 tgactttcca aaaaacacat aatttgaatc aacacaacca cccacagcct aattattagc 10861 atcatccctc tactattttt taaccaaatc aacaacaacc tatttagctg ttccccaacc 10921 ttttcctccg accccctaac aacccccctc ctaatactaa ctacctgact cctacccctc 10981 acaatcatgg caagccaacg ccacttatcc agtgaaccac tatcacgaaa aaaactctac 11041 ctctctatac taatctccct acaaatctcc ttaattataa cattcacagc cacagaacta 11101 atcatatttt atatcttctt cgaaaccaca cttatcccca ccttggctat catcacccga 11161 tgaggcaacc agccagaacg cctgaacgca ggcacatact tcctattcta caccctagta 11221 ggctcccttc ccctactcat cgcactaatt tacactcaca acaccctagg ctcactaaac 11281 attctactac tcactctcac tgcccaagaa ctatcaaact cctgagccaa caacttaata 11341 tgactagctt acacaatagc ttttatagta aagatacctc tttacggact ccacttatga 11401 ctccctaaag cccatgtcga agcccccatc gctgggtcaa tagtacttgc cgcagtactc 11461 ttaaaactag gcggctatgg tataatacgc ctcacactca ttctcaaccc cctgacaaaa 11521 cacatagcct accccttcct tgtactatcc ctatgaggca taattataac aagctccatc 11581 tgcctacgac aaacagacct aaaatcgctc attgcatact cttcaatcag ccacatagcc 11641 ctcgtagtaa cagccattct catccaaacc ccctgaagct tcaccggcgc agtcattctc 11701 ataatcgccc acggacttac atcctcatta ctattctgcc tagcaaactc aaactacgaa 11761 cgcactcaca gtcgcatcat aatcctctct caaggacttc aaactctact cccactaata 11821 gctttttgat gacttctagc aagcctcgct aacctcgcct taccccccac tattaaccta 11881 ctgggagaac tctctgtgct agtaaccacg ttctcctgat caaatatcac tctcctactt 11941 acaggactca acatactagt cacagcccta tactccctct acatatttac cacaacacaa 12001 tgaggctcac tcacccacca cattaacaac ataaaaccct cattcacacg agaaaacacc 12061 ctcatgttca tacacctatc ccccattctc ctcctatccc tcaaccccga catcattacc 12121 gggttttcct cttgtaaata tagtttaacc aaaacatcag attgtgaatc tgacaacaga 12181 ggcttacgac cccttattta ccgagaaagc tcacaagaac tgctaactca tgcccccatg 12241 tctaacaaca tggctttctc aacttttaaa ggataacagc tatccattgg tcttaggccc 12301 caaaaatttt ggtgcaactc caaataaaag taataaccat gcacactact ataaccaccc 12361 taaccctgac ttccctaatt ccccccatcc ttaccaccct cgttaaccct aacaaaaaaa 12421 actcataccc ccattatgta aaatccattg tcgcatccac ctttattatc agtctcttcc 12481 ccacaacaat attcatgtgc ctagaccaag aagttattat ctcgaactga cactgagcca 12541 caacccaaac aacccagctc tccctaagct tcaaactaga ctacttctcc ataatattca 12601 tccctgtagc attgttcgtt acatggtcca tcatagaatt ctcactgtga tatataaact 12661 cagacccaaa cattaatcag ttcttcaaat atctactcat tttcctaatt accatactaa 12721 tcttagttac cgctaacaac ctattccaac tgttcatcgg ctgagagggc gtaggaatta 12781 tatccttctt gctcatcagt tgatgatacg cccgagcaga tgccaacaca gcagccattc 12841 aagcaatcct atacaaccgt atcggcgata tcggtttcat cctcgcctta gcatgattta 12901 tcctacactc caactcatga gacccacaac aaatagccct tctaaacgct aatccaagcc 12961 tcaccccact actaggcctc ctcctagcag cagcaggcaa atcagcccaa ttaggtctcc 13021 acccctgact cccctcagcc atagaaggcc ccaccccagt ctcagcccta ctccactcaa 13081 gcactatagt tgtagcagga atcttcttac tcatccgctt ccacccccta gcagaaaata 13141 gcccactaat ccaaactcta acactatgct taggcgctat caccactctg ttcgcagcag 13201 tctgcgccct tacacaaaat gacatcaaaa aaatcgtagc cttctccact tcaagtcaac 13261 taggactcat aatagttaca atcggcatca accaaccaca cctagcattc ctgcacatct 13321 gtacccacgc cttcttcaaa gccatactat ttatgtgctc cgggtccatc atccacaacc 13381 ttaacaatga acaagatatt cgaaaaatag gaggactact caaaaccata cctctcactt 13441 caacctccct caccattggc agcctagcat tagcaggaat acctttcctc acaggtttct 13501 actccaaaga ccacatcatc gaaaccgcaa acatatcata cacaaacgcc tgagccctat 13561 ctattactct catcgctacc tccctgacaa gcgcctatag cactcgaata attcttctca 13621 ccctaacagg tcaacctcgc ttccccaccc ttactaacat taacgaaaat aaccccaccc 13681 tactaaaccc cattaaacgc ctggcagccg gaagcctatt cgcaggattt ctcattacta 13741 acaacatttc ccccgcatcc cccttccaaa caacaatccc cctctaccta aaactcacag 13801 ccctcgctgt cactttccta ggacttctaa cagccctaga cctcaactac ctaaccaaca 13861 aacttaaaat aaaatcccca ctat