LOCUS AY195785 16567 bp DNA circular PRI 10-JUN-2004 DEFINITION Homo sapiens haplotype A6L2C mitochondrion, complete genome. ACCESSION AY195785 VERSION AY195785.2 GI:48596208 KEYWORDS . SOURCE mitochondrion Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 16567) AUTHORS Mishmar,D., Ruiz-Pesini,E., Golik,P., Macaulay,V., Clark,A.G., Hosseini,S., Brandon,M., Easley,K., Chen,E., Brown,M.D., Sukernik,R.I., Olckers,A. and Wallace,D.C. TITLE Natural selection shaped regional mtDNA variation in humans JOURNAL Proc. Natl. Acad. Sci. U.S.A. 100 (1), 171-176 (2003) MEDLINE 22406325 PUBMED 12509511 REFERENCE 2 (bases 1 to 16567) AUTHORS Mishmar,D., Ruiz-Pesini,E., Golik,P., Macaulay,V., Clark,A.G., Hosseini,S., Brandon,M., Easley,K., Chen,E., Brown,M.D., Sukernik,R.I., Olckers,A. and Wallace,D.C. TITLE Direct Submission JOURNAL Submitted (11-DEC-2002) MAMMAG, University of California, Irvine, 2nd Floor Hewitt Hall, Irvine, California 92697-3940, USA REFERENCE 3 (bases 1 to 16567) AUTHORS Mishmar,D., Ruiz-Pesini,E., Golik,P., Macaulay,V., Clark,A.G., Hosseini,S., Brandon,M., Easley,K., Chen,E., Brown,M.D., Sukernik,R.I., Olckers,A. and Wallace,D.C. TITLE Direct Submission JOURNAL Submitted (10-JUN-2004) MAMMAG, University of California, Irvine, 2nd Floor Hewitt Hall, Irvine, California 92697-3940, USA REMARK Sequence update by submitter COMMENT On Jun 10, 2004 this sequence version replaced gi:29690952. FEATURES Location/Qualifiers source 1..16567 /organism="Homo sapiens" /organelle="mitochondrion" /mol_type="genomic DNA" /isolation_source="L2C haplogroup" /db_xref="taxon:9606" /haplotype="A6L2C" D-loop complement(join(16102..16567,1..191)) tRNA 576..646 /product="tRNA-Phe" rRNA 647..1600 /product="12S ribosomal RNA" tRNA 1601..1669 /product="tRNA-Val" rRNA 1670..3227 /product="16S ribosomal RNA" tRNA 3228..3302 /product="tRNA-Leu" gene 3305..4261 /gene="ND1" CDS 3305..4261 /gene="ND1" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 1" /protein_id="AAO88800.1" /db_xref="GI:29690953" /translation="MPMANLLLLIVPILIAMAFLMLTERKILGYMQLRKGPNVVGPYG LLQPFADAMKLFTKEPLKPATSTITLYITAPTLALTIALLLWTPLPMPNPLVNLNLGL LFILATSSLAVYSILWSGWASNSNYALIGALRAVAQTISYEVTLAIILLSTLLMSGSF NLSTLITTQEHLWLLLPSWPLAMMWFISTLAETNRTPFDLAEGESELVSGFNIEYAAG PFALFFMAEYTNIIMMNTLTTTIFLGTTYDALSPELYTTYFVTKTLLLTSLFLWIRTA YPRFRYDQLMHLLWKNFLPLTLALLMWYVSMPITISSIPPQT" tRNA 4261..4329 /product="tRNA-Ile" tRNA complement(4327..4398) /product="tRNA-Gln" tRNA 4400..4467 /product="tRNA-Met" gene 4468..5511 /gene="ND2" CDS 4468..5511 /gene="ND2" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 2" /protein_id="AAO88801.2" /db_xref="GI:48596209" /translation="MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPIL TKKMNPRSTEAAIKYFLTQATASMILLMAILFNNMLSGQWTMTNTTNQYSSLMIMMAM AMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPSLNVSLLLTLSIL SIMAGSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLL LNLNSSTTTLLLSRTWNKLTWLTPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSL IIPTIMATITLLNLYFYLRLIYSTSITLLPMSNNVKMKWQFEHTKPTPFLPTLIALTT LLLPISPFMLMIL" tRNA 5510..5577 /product="tRNA-Trp" tRNA complement(5585..5653) /product="tRNA-Ala" tRNA complement(5655..5727) /product="tRNA-Asn" tRNA complement(5759..5824) /product="tRNA-Cys" tRNA complement(5824..5889) /product="tRNA-Tyr" gene 5902..7443 /gene="COX1" CDS 5902..7443 /gene="COX1" /codon_start=1 /transl_table=2 /product="cytochrome oxidase subunit I" /protein_id="AAO88802.1" /db_xref="GI:29690955" /translation="MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQP GNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSF WLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILG AINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTT FFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWA MMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKW SAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGG FIHWFPLFSGYTLDQTYAKIHFTIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTW NILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEEP VYMKS" tRNA complement(7443..7514) /product="tRNA-Ser" tRNA 7516..7583 /product="tRNA-Asp" gene 7584..8267 /gene="COX2" CDS 7584..8267 /gene="COX2" /codon_start=1 /transl_table=2 /product="cytochrome oxidase subunit II" /protein_id="AAO88803.2" /db_xref="GI:48596210" /translation="MAHAAQVGLQDATSPIMEELITFHDHALMIIFLICFLVLYALFL TLTTKLTNTNISDAQEMETVWTILPAIILVLIALPSLRILYMTDEVNDPSLTIKSIGH QWYWTYEYTDYGGLIFNSYMLPPLFLEPGDLRLLDVDNRVVLPIEAPIRMMITSQDVL HSWAVPTLGLKTDAIPGRLNQTTFTATRPGVYYGQCSEICGANHSFMPIVLELIPLKI FEMGPVFTL" tRNA 8293..8362 /product="tRNA-Lys" gene 8364..8570 /gene="ATP8" CDS 8364..8570 /gene="ATP8" /codon_start=1 /transl_table=2 /product="ATP synthase F0 subunit 8" /protein_id="AAO88804.1" /db_xref="GI:29690957" /translation="MPQLNTTVWPTMITPMLLTLFLITQLKMLNTNYHLPPSPKPMKM KNYNKPWEPKWTKICSLHSLPPQS" gene 8525..9205 /gene="ATP6" CDS 8525..9205 /gene="ATP6" /codon_start=1 /transl_table=2 /product="ATP synthase F0 subunit 6" /protein_id="AAO88805.1" /db_xref="GI:29690958" /translation="MNENLFASFIAPTILGLPAAVLIILFPPLLIPTSKYLINNRLIT TQQWLIKLTSKQMMAMHNTKGRTWSLMLVSLIIFIATTNLLGLLPHSFTPTTQLSMNL AMAIPLWAGAVIMGFRSKIKNALAHFLPQGTPTPLIPMLVIIETISLLIQPMALAVRL TANITAGHLLMHLIGSATLAMSTINLPSTLIIFTILILLTILEIAVALIQAYVFTLLV SLYLHDNT" gene 9205..9985 /gene="COX3" CDS 9205..9985 /gene="COX3" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:9985,aa:TERM) /transl_table=2 /product="cytochrome oxidase subunit III" /protein_id="AAO88806.2" /db_xref="GI:48596211" /translation="MTHQSHAYHMVKPSPWPLTGALSALLMTSGLAMWFHFHSMTLLM LGLLTNTLTMYQWWRDVTRESTYQGHHTPPVQKGLRYGMILFITSEVFFFAGFFWAFY HSSLAPTPQLGGHWPPTGITPLNPLEVPLLNTSVLLASGVSITWAHHSLMENNRNQMI QALLITILLGLYFTLLQASEYFESPFTISDGIYGSTFFVATGFHGLHVIIGSTFLTIC FIRQLMFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIYWWG" tRNA 9989..10056 /product="tRNA-Gly" gene 10057..10402 /gene="ND3" CDS 10057..10402 /gene="ND3" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:10402,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 3" /protein_id="AAO88807.2" /db_xref="GI:48596212" /translation="MNFALILMINTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPM SPARVPFSMKFFLVAITFLLFDLEIALLLPLPWALQTTNLPLMVMSSLLLIIILALSL AYEWLQKGLDWAE" tRNA 10403..10467 /product="tRNA-Arg" gene 10468..10764 /gene="ND4L" CDS 10468..10764 /gene="ND4L" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 4L" /protein_id="AAO88808.1" /db_xref="GI:29690961" /translation="MPLIYMNIMLAFTISLLGMLVYRSHLMSSLLCLEGMMLSLFIMA TLMTLNTHSLLANIVPIAMLVFAACEAAVGLALLVSISNTYGLDYVHNLNLLQC" gene 10758..12135 /gene="ND4" CDS 10758..12135 /gene="ND4" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:12135,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 4" /protein_id="AAO88809.1" /db_xref="GI:29690962" /translation="MLKLIVPTIMLLPLTWLSKKHMIWINTTTHSLIISIIPLLFFNQ INNNLFSCSPTFSSDPLTTPLLMLTTWLLPLTIMASQRHLSSEPLSRKKLYLSMLISL QISLIMTFTATELIMFYIFFETTLIPTLAIITRWGNQPERLNAGTYFLFYTLVGSLPL LIALIYTHNTLGSLNILLLTLTAQELSNSWANNLMWLAYTMAFMVKMPLYGLHLWLPK AHVEAPIAGSMVLAAVLLKLGGYGMMRLTLILNPLTKHMAYPFLVLSLWGMIMTSSIC LRQTDLKSLIAYSSISHMALVVTAILIQTPWSFTGAVILMIAHGLTSSLLFCLANSNY ERTHSRIMILSQGLQTLLPLMAFWWLLASLANLALPPTINLLGELSVLVTTFSWSNIT LLLTGLNMLVTALYSLYMFTTTQWGSLTHHINNMKPSFTRENTLMFMHLSPILLLSLN PDIITGFSS" tRNA 12136..12204 /product="tRNA-His" tRNA 12205..12263 /product="tRNA-Ser" tRNA 12264..12334 /product="tRNA-Leu" gene 12335..14146 /gene="ND5" CDS 12335..14146 /gene="ND5" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 5" /protein_id="AAO88810.1" /db_xref="GI:29690963" /translation="MTMHTTMTTLTLTSLIPPILTTLVNPNKKNSYPHYVKSIVASTF IISLFPTTMFMCLDQEVIISNWHWATTQTTQLSLSFKLDYFSMMFIPVALFVTWSIME FSLWYMNSDPNINQFFKYLLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLISWWYA RADANTAAIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLNANPSLTPLLGLLL AAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFHPLAENSPLIQTL TLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAF FKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSK DHIIETANMSYTNAWALSITLIATSLTSAYSTRMILLTLTGQPRFPTLTNINENNPTL LNPIKRLAAGSLFAGFLITNNISPASPFQTTIPLYLKLTALAVTFLGLLTALDLNYLT NKLKMKSPLCTFYFSNMLGFYPTITHRTIPYLALLTSQNLPLLLLDLTWLEKLLPKTI SQHQISTSIITSTQKGMIKLYFLSFFFPLILTLLLIT" gene complement(14147..14671) /gene="ND6" CDS complement(14147..14671) /gene="ND6" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 6" /protein_id="AAO88811.1" /db_xref="GI:29690964" /translation="MMYALFLLSVGLVMGFVGFSSKPSPIYGGLVLIVSGVVGCVIIL NFGGGYMGLMVFLIYLGGMMVVFGYTTAMAIEEYPEAWGSGVEVLVSVLVGLAMEVGL VLWVKEYDGVVVVVNFNSVGSWMIYEGEGSGLIREDPIGAGALYDYGRWLVVVTGWTL FVGVYIVIEIARGN" tRNA complement(14672..14740) /product="tRNA-Glu" gene 14745..15879 /gene="cytb" CDS 14745..15879 /gene="cytb" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:15879,aa:TERM) /transl_table=2 /product="cytochrome b" /protein_id="AAO88812.2" /db_xref="GI:48596213" /translation="MTPMRKINPLMKLINHSFIDLPTPSNISAWWNFGSLLGACLILQ ITTGLFLAMHYSPDASTAFSSIAHITRDVNYGWIIRYLHANGASMFFICLFLHIGRGL YYGSFLYSETWNIGIILLLTTMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDL VQWIWGGYSVDSPTLTRFFTFHFILPFIIAALAALHLLFLHETGSNNPLGITSHSDKI TFHPYYTIKDALGLLLFLLSLMTLTLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLF AYTILRSVPNKLGGVLALLLSILILAMIPILHMSKQQSMMFRPLSQSLYWLLAADLLI LTWIGGQPVSYPFTIIGQVASVLYFTTILILMPIISLIENKMLK" tRNA 15886..15951 /product="tRNA-Thr" tRNA complement(15953..16021) /product="tRNA-Pro" ORIGIN 1 gatcacaggt ctatcaccct attaaccact cacgggagct ctccatgcat ttggtatttt 61 cgtctggggg gtgtgcacgc gatagcattg cgggacgctg gagccggagc accctatgtc 121 gcagtatctg tctttgattc ctgccccatt ccattattta tcgcacctac gttcaatatt 181 ataggcgaac atacctatta aagtgtgtta attaattaat gcttgtagga cataataata 241 acaattgaat gtctgcacag ccgctttcca cacagacatc ataacaaaaa atttccacca 301 aaccccccct ccccccgctt ctggctacag cacttaaaca catctctgcc aaaccccaaa 361 aacaaagaac cctaacacca gcctaaccag atttcaaatt ttatcttttg gcggtatgca 421 cttttaacag tcacccccca actaacacat tattttcccc tcccactccc atactactaa 481 tctcatcaat acaacccccg cccatcctac ccagcacaca caccgctgct aaccccatac 541 cccgaaccaa ccaaacccca aagacacccc ccacagttta tgtagcttac ctcctcaaag 601 caatacactg aaaatgttta gacgggctca catcacccca taaacaaata ggtttggtcc 661 tagcctttct attagctcct agtaagatta cacatgcaag catccccatt ccagtgagtt 721 caccctctaa atcaccacga tcaaaaggga caagcatcaa gcacgcaaca atgcagctca 781 aaacgcttag cctagccaca cccccacggg aaacagcagt gattaacctt tagcaataaa 841 cgaaagttta actaagctat actaacccca gggttggtca atttcgtgcc agccaccgcg 901 gtcacacgat taacccaagt caatagaagc cggcgtaaag agtgttttag atcaccccct 961 ccccaataaa gctaaaactc acctgagttg taaaaaactc cagttgacac aaaataaact 1021 acgaaagtgg ctttaacata tctgaacaca caatagctaa gacccaaact gggattagat 1081 accccactat gcttagccct aaacctcaac agttaaatca acaaaactgc tcgccagaac 1141 actacgagcc acagcttaaa actcaaagga cctggcggtg cttcatatcc ctctagagga 1201 gcctgttctg taatcgataa accccgatca acctcaccac ctcttgctca gcctatatac 1261 cgccatcttc agcaaaccct gatgaaggct acaaagtaag cgcaagtacc cacgtaaaga 1321 cgttaggtca aggtgtagcc catgaggtgg caagaaatgg gctacatttt ctaccccaga 1381 aaactacgat agcccttatg aaacttaagg gtcgaaggtg gatttagcag taaactgaga 1441 atagagtgct tagttgaaca gggccctgaa gcgcgtacac accgcccgtc accctcctca 1501 agtatacttc aaaggacatt taactaaaac ccctacgcat ttatatagag gagacaagtc 1561 gtaacatggt aagtgtactg gaaagtgcac ttggacgaac cagagtgtag cttaacacaa 1621 agcacccaac ttacacttag gagatttcaa cttaacttga ccgctctgag ctaaacctag 1681 ccccaaaccc actccacctt actaccagac aaccttagcc aaaccattta cccaaataaa 1741 gtataggcga tagaaattga aacctggcgc aatagatata gtaccgcaag ggaaagatga 1801 aaaattataa ccaagcataa tatagcaagg actaacccct ataccttctg cataatgaat 1861 taactagaaa taactttgca aggagagcca aagctaagac ccccgaaacc agacgagcta 1921 cctaagaaca gctaaaagag cacacccgtc tatgtagcaa aatagtggga agatttatag 1981 gtagaggcga caaacctacc gagcctggtg atagctggtt gtccaagata gaatcttagt 2041 tcaactttaa atttgcccac agaaccctct aaatcccctt gtaaatttaa ctgttagtcc 2101 aaagaggaac agctctttgg acactaggaa aaaaccttgt agagagagta aaaaatttaa 2161 cacccatagt aggcctaaaa gcagccacca attaagaaag cgttcaagct caacacccac 2221 tacctaaaaa atcccaaaca tataactgaa ctcctcacac ccaattggac caatctatca 2281 ccctatagaa gaactaatgt tagtataagt aacatgaaaa cattctcctc tgcataagcc 2341 tgcgtcagat taaaacactg aactgacaat taacagccca atatctacaa tcaaccaaca 2401 agtcattatt acccccactg tcaacccaac acaggcatgc tcataaggaa aggttaaaaa 2461 aagtaaaagg aactcggcaa atcttacccc gcctgtttac caaaaacatc acctctagca 2521 tcaccagtat tagaggcacc gcctgcccag tgacacatgt ttaacggccg cggtacccta 2581 accgtgcaaa ggtagcataa tcacttgttc cttaaatagg gacctgtatg aatggctcca 2641 cgagggttca gctgtctctt acttttaacc agtgaaattg acctgcccgt gaagaggcgg 2701 gcatgacaca gcaagacgag aagaccctat ggagctttaa tttattaatg caaacagtac 2761 ctaacaaacc cacaggtcct aaactaccaa acctgcatta aaaatttcgg ttggggcgac 2821 ctcggagcag aacccaacct ccgagcagta catgctaaga cttcaccagt caaagcgaac 2881 tactatactc aattgatcca ataacttgac caacggaaca agttacccta gggataacag 2941 cgcaatccta ttctagagtc catatcaaca atagggttta cgacctcgat gttggatcag 3001 gacatcccga tggtgcagcc gctattaaag gttcgtttgt tcaacgatta aagtcctacg 3061 tgatctgagt tcagaccgga gtaatccagg tcggtttcta tctacttcaa attcctccct 3121 gtacgaaagg acaagagaaa taaggcctac ttcacaaagc gccttccccc gtaaatgata 3181 tcatctcaac ttagtataat acccacaccc acccaagagc agggtttgtt aagatggcag 3241 agcccggtaa tcgcataaaa cttaaaactt tacagtcaga ggttcaattc ctcttcttaa 3301 caacataccc atggccaacc tcctactcct cattgtaccc attctaatcg caatggcatt 3361 cctaatgctt accgaacgaa aaattctagg ctatatacaa ctacgcaaag gccccaacgt 3421 tgtaggcccc tacgggctac tacaaccctt cgctgacgcc ataaaactct tcaccaaaga 3481 gcccctaaaa cccgccacat ctaccatcac cctctacatc accgccccga ccttagctct 3541 caccatcgct cttctactat gaacccccct ccccataccc aaccccctgg ttaacctcaa 3601 cctaggcctc ctatttattc tagccacctc tagcctagcc gtttactcaa tcctctgatc 3661 agggtgagca tcaaactcaa actacgccct gatcggcgca ctgcgagcag tagcccaaac 3721 aatctcatat gaagtcaccc tagccatcat tctactatca acattactaa taagtggctc 3781 ctttaacctc tccaccctta tcacaacaca agaacacctc tgattactcc tgccatcatg 3841 acccttggcc ataatatgat ttatctccac actagcagag accaaccgaa cccccttcga 3901 ccttgccgaa ggggagtccg aactagtctc aggcttcaac atcgaatacg ccgcaggccc 3961 cttcgcccta ttcttcatag ccgaatacac aaacattatt ataataaaca ccctcaccac 4021 tacaatcttc ctaggaacaa catatgacgc actctcccct gaactctaca caacatattt 4081 tgtcaccaag accctacttc tgacctccct gttcttatga attcgaacag catacccccg 4141 attccgctac gaccaactca tacacctcct atgaaaaaac ttcctaccac tcaccctagc 4201 attacttata tgatatgtct ccatacccat tacaatctcc agcattcccc ctcaaaccta 4261 agaaatatgt ctgataaaag agttactttg atagagtaaa taataggagc ttaaaccccc 4321 ttatttctag gactatgaga atcgaaccca tccctgagaa tccaaaattc tccgtgccac 4381 ctatcacacc ccatcctaaa gtaaggtcag ctaaataagc tatcgggccc ataccccgaa 4441 aatgttggtt atacccttcc cgtactaatt aatcccctgg cccaacccgt catctactct 4501 accatctttg caggcacact catcacagcg ctaagctcgc actgattttt tacctgagta 4561 ggcctagaaa taaacatgct agcttttatt ccaattctaa ccaaaaaaat aaaccctcgt 4621 tccacagaag ctgccatcaa gtatttcctc acgcaagcaa ccgcatccat aatccttcta 4681 atagctatcc tcttcaacaa tatactctcc ggacaatgaa ccataaccaa tactaccaat 4741 caatactcat cattaataat cataatggct atagcaataa aactaggaat agcccccttt 4801 cacttctgag tcccagaggt tacccaaggc acccctctga catccggcct gcttcttctc 4861 acatgacaaa aactagcccc catctcaatc atataccaaa tctctccctc actaaacgta 4921 agccttctcc tcactctctc aatcttatcc atcatagcag gcagttgagg tggattaaac 4981 caaacccagc tacgcaaaat cttagcatac tcctcaatta cccacatagg atgaataata 5041 gcagttctac cgtacaaccc taacataacc attcttaatt taactattta tattatccta 5101 actactaccg cattcctact actcaactta aactccagca ccacgaccct actactatct 5161 cgcacctgaa acaagctaac atgactaaca cccttaattc catccaccct cctctcccta 5221 ggaggcctgc ccccgctaac cggctttttg cccaaatggg ccattatcga agaattcaca 5281 aaaaacaata gcctcatcat ccccaccatc atagccacca tcaccctcct taacctctac 5341 ttctacctac gcctaatcta ctccacctca atcacactac tccccatatc taacaacgta 5401 aaaataaaat gacagtttga acatacaaaa cccaccccat tcctccccac actcatcgcc 5461 cttaccacgc tactcctacc tatctcccct tttatactaa taatcttata gaaatttagg 5521 ttaaatacag accaagagcc ttcaaagccc tcagtaagtt gcaatactta atttctgtaa 5581 cagctaagga ctgcaaaacc ccactctgca tcaactgaac gcaaatcagc cactttaatt 5641 aagctaagcc cttactagac caatgggact taaacccaca aacacttagt taacagctaa 5701 gcaccctaat caactggctt caatctactt ctcccgccgc cgggaaaaaa ggcgggagaa 5761 gccccggcag gtttgaagct gcttcttcga atttgcaatt caatatgaaa atcacctcgg 5821 agctggtaaa aagaggccta acccctgtct ttagatttac agtccaatgc ttcactcagc 5881 cattttacct cacccccact gatgttcgcc gaccgttgac tattctctac aaaccacaaa 5941 gacattggaa cactatacct attattcggc gcatgagctg gagtcctagg cacagctcta 6001 agcctcctta ttcgagccga gctgggccag ccaggcaacc ttctaggtaa cgaccacatc 6061 tacaacgtta tcgtcacagc ccatgcattt gtaataatct tcttcatagt aatacccatc 6121 ataatcggag gctttggcaa ctgactagtt cccctaataa tcggtgcccc cgatatggcg 6181 tttccccgca taaacaacat aagcttctga ctcttacctc cctctctcct actcctgctc 6241 gcatctgcta tagtggaggc cggagcagga acaggttgaa cagtctaccc tcccttagca 6301 gggaactact cccaccctgg agcctccgta gacctaacca tcttctcctt acacctagca 6361 ggtgtctcct ctatcttagg ggccatcaat ttcatcacaa caattatcaa tataaaaccc 6421 cctgccataa cccaatacca aacgcccctc ttcgtctgat ccgtcctaat cacagcagtc 6481 ctacttctcc tatctctccc agtcctagct gctggcatca ctatactact aacagaccgc 6541 aacctcaaca ccaccttctt cgaccccgcc ggaggaggag accccattct ataccaacac 6601 ctattctgat ttttcggtca ccctgaagtt tatattctta tcctaccagg cttcggaata 6661 atctcccata ttgtaactta ctactccgga aaaaaagaac catttggata cataggtatg 6721 gtctgagcta tgatatcaat tggcttccta gggtttatcg tgtgagcaca ccatatattt 6781 acagtaggaa tagacgtaga cacacgagca tatttcacct ccgctaccat aatcatcgct 6841 atccccaccg gcgtcaaagt atttagctga ctcgccacac tccacggaag caatatgaaa 6901 tgatctgctg cagtgctctg agccctagga ttcatctttc ttttcaccgt aggtggcctg 6961 actggcattg tattagcaaa ctcatcacta gacatcgtac tacacgacac gtactacgtt 7021 gtagctcact tccactatgt cctatcaata ggagctgtat ttgccatcat aggaggcttc 7081 attcactgat ttcccctatt ctcaggctac accctagacc aaacctacgc caaaatccat 7141 ttcactatca tattcatcgg cgtaaatcta actttcttcc cacaacactt tctcggccta 7201 tccggaatgc cccgacgtta ctcggactac cccgatgcat acaccacatg aaatatccta 7261 tcatctgtag gctcattcat ttctctaaca gcagtaatat taataatttt catgatttga 7321 gaagccttcg cttcgaagcg aaaagtccta atagtagaag aaccctccat aaacctggag 7381 tgactatatg gatgcccccc accctaccac acattcgaag aacccgtata cataaaatct 7441 agacaaaaaa ggaaggaatc gaacccccca aagctggttt caagccaacc ccatggcctc 7501 catgactttt tcaaaaagat attagaaaaa ccatttcata actttgtcaa agttaaatta 7561 taggctaaat cctatatatc ttaatggcac atgcagcgca agtaggtcta caagacgcta 7621 catcccctat catagaagag cttatcacct ttcatgatca cgccctcata atcattttcc 7681 ttatctgctt cctagtcctg tatgcccttt tcctaacact cacaacaaaa ctaactaata 7741 ctaacatctc agacgctcag gaaatagaaa ccgtctgaac tatcctgccc gccatcatcc 7801 tagtcctcat cgccctccca tccctacgca tcctttacat aacagacgag gtcaacgatc 7861 cctcccttac catcaaatca attggccacc aatggtactg aacctacgag tacaccgact 7921 acggcggact aatcttcaac tcctacatac ttcccccatt attcctagaa ccaggcgacc 7981 tgcgactcct tgacgttgac aatcgagtag tactcccgat tgaagccccc attcgtataa 8041 taattacatc acaagacgtc ttgcactcat gagctgtccc cacattaggc ttaaaaacag 8101 atgcaattcc cggacgtcta aaccaaacca ctttcaccgc tacacgaccg ggggtatact 8161 acggtcaatg ctctgaaatc tgtggagcaa accacagttt catacccatc gtcctagaat 8221 taattcccct aaaaatcttt gaaatagggc ccgtatttac cctatagcac cccctctacc 8281 ccctctagag cccactgtaa agctaactta gcattaacct tttaagttaa agattaagag 8341 aaccaacacc tctttacagt gaaatgcccc aactaaatac taccgtatgg cccaccataa 8401 ttacccccat actccttaca ctattcctca tcacccaact aaaaatatta aacacaaact 8461 accacctacc tccctcacca aagcccataa aaataaaaaa ttataacaaa ccctgagaac 8521 caaaatgaac gaaaatctgt tcgcttcatt cattgccccc acaatcctag gcctacccgc 8581 cgcagtactg atcattctat ttccccctct attgatcccc acctccaaat atctcatcaa 8641 caaccgacta atcaccaccc aacaatgact aatcaaacta acctcaaaac aaatgatagc 8701 catacacaac actaaaggac gaacctgatc tcttatacta gtatccttaa tcatttttat 8761 tgccacaact aacctcctcg gactcctgcc tcactcattt acaccaacca cccaactatc 8821 tataaaccta gccatggcca tccccttatg agcgggcgca gtgattatag gctttcgctc 8881 taagattaaa aatgccctag cccacttctt accacaaggc acacctacac cccttatccc 8941 catactagtt attatcgaaa ccatcagcct actcattcaa ccaatagccc tggccgtacg 9001 cctaaccgct aacattactg caggccacct actcatgcac ctaattggaa gcgccaccct 9061 agcaatatca accattaacc ttccctctac acttatcatc ttcacaattc taattctact 9121 gactatccta gaaatcgctg tcgccttaat ccaagcctac gttttcacac ttctagtaag 9181 cctctacctg cacgacaaca cataatgacc caccaatcgc atgcctatca tatagtaaaa 9241 cccagcccat gacccctaac aggggccctc tcagccctcc taatgacctc cggcctagcc 9301 atgtgatttc acttccactc cataacgctc ctcatactag gcctactaac caacacacta 9361 accatatacc aatgatggcg cgatgtaaca cgagaaagca cataccaagg ccaccacaca 9421 ccacctgtcc aaaaaggcct tcgatacggg ataatcctat ttattacctc agaagttttt 9481 ttcttcgcag gatttttctg agccttttac cactccagcc tagcccctac cccccaacta 9541 ggagggcact ggcccccaac aggcatcacc ccgctaaatc ccctagaagt cccactccta 9601 aacacatccg tattactcgc atcaggagta tcaatcacct gagctcacca tagtctaata 9661 gaaaacaacc gaaaccaaat aattcaagca ctgcttatta caattttact gggtctctat 9721 tttaccctcc tacaagcctc agagtacttc gagtctccct tcaccatttc cgacggcatc 9781 tacggctcaa cattttttgt agccacaggc ttccacggac ttcacgtcat tattggctca 9841 actttcctca ctatctgctt catccgccaa ctaatatttc actttacatc caaacatcac 9901 tttggcttcg aagccgccgc ctgatactgg cattttgtag atgtggtttg actatttctg 9961 tatgtctcca tctattgatg agggtcttac tcttttagta taaatagtac cgttaacttc 10021 caattaacta gttttgacaa cattcaaaaa agagtaataa acttcgcctt aattttaata 10081 atcaacaccc tcctagcctt actactaata atcattacat tttgactacc acaactcaac 10141 ggctacatag aaaaatccac cccttacgag tgcggcttcg accctatatc ccccgcccgc 10201 gtccctttct ccataaaatt cttcttagta gctattacct tcttattatt tgatctagaa 10261 attgccctcc ttttacccct accatgagcc ctacaaacaa ctaacctgcc actaatagtt 10321 atgtcatccc tcttattaat catcatccta gccctaagtc tggcctatga gtgactacaa 10381 aaaggattag actgagccga attggtatat agtttaaaca aaacgaatga tttcgactca 10441 ttaaattatg ataatcatat ttaccaaatg cccctcattt acataaatat tatactagca 10501 tttaccatct cacttctagg aatactagta tatcgctcac acctcatatc ctccctacta 10561 tgcctagaag gaataatact atcgctgttc attatagcta ctctcataac cctcaacacc 10621 cactccctct tagccaatat tgtgcctatt gccatactag tctttgccgc ctgcgaagca 10681 gcggtgggcc tagccctact agtctcaatc tccaacacat atggcctaga ctacgtacat 10741 aacctaaacc tactccaatg ctaaaactaa tcgtcccaac aattatatta ctaccactga 10801 catgactttc caaaaaacac ataatttgaa tcaacacaac cacccacagc ctaattatta 10861 gcatcatccc cctactattt tttaaccaaa tcaacaacaa cctatttagc tgttccccaa 10921 ccttttcctc cgacccccta acaacccccc tcctaatact aactacctga ctcctacccc 10981 tcacaatcat ggcaagccaa cgccacttat ccagtgaacc actatcacga aaaaaactct 11041 acctctctat actaatctcc ctacaaatct ccttaattat aacattcaca gccacagaac 11101 taatcatatt ttatatcttc ttcgaaacca cacttatccc caccttggct atcatcaccc 11161 gatgaggcaa ccagccagaa cgcctgaacg caggcacata cttcctattc tacaccctag 11221 taggctccct tcccctactc atcgcactaa tttacactca caacacccta ggctcactaa 11281 acattctact actcactctc actgcccaag aactatcaaa ctcctgagcc aacaacttaa 11341 tatgactagc ttacacaata gcttttatag taaagatacc tctttacgga ctccacttat 11401 gactccctaa agcccatgtc gaagccccca tcgctgggtc aatagtactt gccgcagtac 11461 tcttaaaact aggcggctat ggtataatac gcctcacact cattctcaac cccctgacaa 11521 aacacatagc ctaccccttc cttgtactat ccctatgagg cataattata acaagctcca 11581 tctgcctacg acaaacagac ctaaaatcgc tcattgcata ctcttcaatc agccacatag 11641 ccctcgtagt aacagccatt ctcatccaaa ccccctgaag cttcaccggc gcagtcattc 11701 tcataatcgc ccacggactt acatcctcat tactattctg cctagcaaac tcaaactacg 11761 aacgcactca cagtcgcatc ataatcctct ctcaaggact tcaaactcta ctcccactaa 11821 tagctttttg atgacttcta gcaagcctcg ctaacctcgc cttacccccc actattaacc 11881 tactgggaga actctctgtg ctagtaacca cgttctcctg atcaaatatc actctcctac 11941 tcacaggact caacatacta gtcacagccc tatactccct ctacatattt accacaacac 12001 aatggggctc actcacccac cacattaaca acataaaacc ctcattcaca cgagaaaaca 12061 ccctcatgtt catacaccta tcccccattc tcctcctatc cctcaacccc gacatcatta 12121 ccgggttttc ctcttgtaaa tatagtttaa ccaaaacatc agattgtgaa tctgacaaca 12181 gaggcttacg accccttatt taccgagaaa gctcacaaga actgctaact cataccccca 12241 tgtctaacaa catggctttc tcaactttta aaggataaca gctatccatt ggtcttaggc 12301 cccaaaaatt ttggtgcaac tccaaataaa agtaataacc atgcacacta ctataaccac 12361 cctaaccctg acttccctaa ttccccccat ccttaccacc ctcgttaacc ctaacaaaaa 12421 aaactcatac ccccattatg taaaatccat tgtcgcatcc acctttatta tcagtctctt 12481 ccccacaaca atattcatgt gcctagacca agaagttatt atctcgaact gacactgagc 12541 cacaacccaa acaacccagc tctccctaag cttcaaacta gactacttct ccataatatt 12601 catccctgta gcattgttcg ttacatggtc catcatagaa ttctcactgt gatatataaa 12661 ctcagaccca aacattaatc agttcttcaa atatctactc attttcctaa ttaccatact 12721 aatcttagtt accgctaaca acctattcca actgttcatc ggctgagagg gcgtaggaat 12781 tatatccttc ttgctcatca gttgatgata cgcccgagca gatgccaaca cagcagccat 12841 tcaagcaatc ctatacaacc gtatcggcga tatcggtttc atcctcgcct tagcatgatt 12901 tatcctacac tccaactcat gagacccaca acaaatagcc cttctaaacg ctaatccaag 12961 cctcacccca ctactaggcc tcctcctagc agcagcaggc aaatcagccc aattaggtct 13021 ccacccctga ctcccctcag ccatagaagg ccccacccca gtctcagccc tactccactc 13081 aagcactata gttgtagcag gaatcttctt actcatccgc ttccaccccc tagcagaaaa 13141 tagcccacta atccaaactc taacactatg cttaggcgct atcaccactc tgttcgcagc 13201 agtctgcgcc cttacacaaa atgacatcaa aaaaatcgta gccttctcca cttcaagtca 13261 actaggactc ataatagtta caatcggcat caaccaacca cacctagcat tcctgcacat 13321 ctgtacccac gccttcttca aagccatact atttatgtgc tccgggtcca tcatccacaa 13381 ccttaacaat gaacaagata ttcgaaaaat aggaggacta ctcaaaacca tacctctcac 13441 ttcaacctcc ctcaccattg gcagcctagc attagcagga atacctttcc tcacaggttt 13501 ctactccaaa gaccacatca tcgaaaccgc aaacatatca tacacaaacg cctgagccct 13561 atctattact ctcatcgcta cctccctaac aagcgcctat agcactcgaa taattcttct 13621 caccctaaca ggtcaacctc gcttccctac ccttactaac attaacgaaa ataaccccac 13681 cctactaaac cccattaaac gcctggcagc cggaagccta ttcgcaggat ttctcattac 13741 taacaacatt tcccccgcat cccccttcca aacaacaatc cccctctacc taaaactcac 13801 agccctcgct gtcactttcc taggacttct aacagcccta gacctcaact acctaaccaa 13861 caaacttaaa ataaaatccc cactatgcac attttatttc tccaacatac tcggattcta 13921 ccctaccatc acacaccg