LOCUS AY195777 16557 bp DNA circular PRI 10-JUN-2004 DEFINITION Homo sapiens haplotype A10L1A2 mitochondrion, complete genome. ACCESSION AY195777 VERSION AY195777.1 GI:29690840 KEYWORDS . SOURCE mitochondrion Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 16557) AUTHORS Mishmar,D., Ruiz-Pesini,E., Golik,P., Macaulay,V., Clark,A.G., Hosseini,S., Brandon,M., Easley,K., Chen,E., Brown,M.D., Sukernik,R.I., Olckers,A. and Wallace,D.C. TITLE Natural selection shaped regional mtDNA variation in humans JOURNAL Proc. Natl. Acad. Sci. U.S.A. 100 (1), 171-176 (2003) MEDLINE 22406325 PUBMED 12509511 REFERENCE 2 (bases 1 to 16557) AUTHORS Mishmar,D., Ruiz-Pesini,E., Golik,P., Macaulay,V., Clark,A.G., Hosseini,S., Brandon,M., Easley,K., Chen,E., Brown,M.D., Sukernik,R.I., Olckers,A. and Wallace,D.C. TITLE Direct Submission JOURNAL Submitted (11-DEC-2002) MAMMAG, University of California, Irvine, 2nd Floor Hewitt Hall, Irvine, California 92697-3940, USA FEATURES Location/Qualifiers source 1..16557 /organism="Homo sapiens" /organelle="mitochondrion" /mol_type="genomic DNA" /isolation_source="L1A2 haplogroup" /db_xref="taxon:9606" /haplotype="A10L1A2" D-loop complement(join(16092..16557,1..191)) tRNA 575..645 /product="tRNA-Phe" rRNA 646..1599 /product="12S ribosomal RNA" tRNA 1600..1668 /product="tRNA-Val" rRNA 1669..3226 /product="16S ribosomal RNA" tRNA 3227..3301 /product="tRNA-Leu" gene 3304..4260 /gene="ND1" CDS 3304..4260 /gene="ND1" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 1" /protein_id="AAO88696.1" /db_xref="GI:29690841" /translation="MPMANLLLLIVPILIAMAFLMLTERKILGYMQLRKGPNVVGPYG LLQPFADAMKLFTKEPLKPATSTITLYITAPTLALTIALLLWTPLPMPNPLVNLNLGL LFILATSSLAVYSILWSGWASNSNYALIGALRAVAQTISYEVTLAIILLSTLLMSGSF NLSTLITTQEHLWLLLPSWPLAMMWFISTLAETNRTPFDLAEGESELVSGFNIEYAAG PFALFFMAEYTNIIMMNTLTTMIFLGTTYDALSPELYTTYFVTKTLLLTSLFLWIRTA YPRFRYDQLMHLLWKNFLPLTLALLMWYVSVPTTISSIPPQT" tRNA 4260..4328 /product="tRNA-Ile" tRNA complement(4326..4397) /product="tRNA-Gln" tRNA 4399..4466 /product="tRNA-Met" gene 4467..5510 /gene="ND2" CDS 4467..5510 /gene="ND2" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 2" /protein_id="AAO88697.1" /db_xref="GI:29690842" /translation="MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVL TKKMNPRSTEAAIKYFLTQATASMILLMAILFNNMLSGQWTMTNTTNQYSSLMIMMAM AMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPSLNVSLLLTLSIL SIMAGSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLL LNLNSSTTTLLLSRTWNKLTWLTPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSL IIPTIMATITLLNLYFYLRLIYSTSITLLPMSNNVKMKWQFEHTKPTPLLPTLIALTT LLLPISPFMLMIL" tRNA 5509..5576 /product="tRNA-Trp" tRNA complement(5584..5652) /product="tRNA-Ala" tRNA complement(5654..5726) /product="tRNA-Asn" tRNA complement(5758..5823) /product="tRNA-Cys" tRNA complement(5823..5888) /product="tRNA-Tyr" gene 5901..7442 /gene="COX1" CDS 5901..7442 /gene="COX1" /codon_start=1 /transl_table=2 /product="cytochrome oxidase subunit I" /protein_id="AAO88698.1" /db_xref="GI:29690843" /translation="MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQP GNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSF WLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILG AINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTT FFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWA MMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKW SAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGG FIHWFPLFSGYTLDQTYAKIHFAIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTW NILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEEP VYMKS" tRNA complement(7442..7513) /product="tRNA-Ser" tRNA 7515..7582 /product="tRNA-Asp" gene 7583..8266 /gene="COX2" CDS 7583..8266 /gene="COX2" /codon_start=1 /transl_table=2 /product="cytochrome oxidase subunit II" /protein_id="AAO88699.1" /db_xref="GI:29690844" /translation="MAHAAQVGLQDATSPIMEELITFHDHALMIIFLICFLVLYALFL TLTTKLTNTNISDAQEMETVWTILPAIILVLIALPSLRILYMTDEVNDPSLTIKSIGH QWYWTYEYTDYGGLIFNSYMLPPLFLEPGDLRLLDVDNRVVLPIEAPIRMMITSQDVL HSWAVPTLGLKTDAIPGRLNQTTFTATRPGVYYGQCSEICGANHSFMPIVLELIPLKI FEMGPVFTL" tRNA 8283..8352 /product="tRNA-Lys" gene 8354..8560 /gene="ATP8" CDS 8354..8560 /gene="ATP8" /codon_start=1 /transl_table=2 /product="ATP synthase F0 subunit 8" /protein_id="AAO88700.1" /db_xref="GI:29690845" /translation="MPQLNTTVWPTMITPMLLTLFLITQLKMLNTNYHLPPSPKPMKM KNYNKPWEPKWTKICSLHSLPPQS" gene 8515..9195 /gene="ATP6" CDS 8515..9195 /gene="ATP6" /codon_start=1 /transl_table=2 /product="ATP synthase F0 subunit 6" /protein_id="AAO88701.1" /db_xref="GI:29690846" /translation="MNENLFTSFIAPTILGLPAAVLIILFPPLLIPTSKYLINNRLIT TQQWLIKLTSKQMMAMHNTKGRTWSLMLVSLIIFIATTNLLGLLPHSFTPTTQLSMNL AMAIPLWAGAVIMGFRSKIKNALAHFLPQGTPTPLIPMLVIIETISLLIQPMALAVRL TANITAGHLLMHLIGSATLAMSTINLPSTLIIFTILILLTILEIAVALIQAYVFTLLV SLYLHDNT" gene 9195..9975 /gene="COX3" CDS 9195..9975 /gene="COX3" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:9975,aa:TERM) /transl_table=2 /product="cytochrome oxidase subunit III" /protein_id="AAO88702.1" /db_xref="GI:29690847" /translation="MTHQSHAYHMVKPSPWPLTGALSALLMTSGLAMWFHFHSMTLLM LGLLTNTLTMYQWWRDVTRESTYQGHHTPPVQKGLRYGMILFITSEVFFFAGFFWAFY HSSLAPTPQLGGHWPPTGITPLNPLEVPLLNTSVLLASGVSITWAHHSLMENNRNQMI QALLITILLGLYFTLLQASEYFESPFTISDGIYGSTFFVATGFHGLHVIIGSTFLTIC FIRQLMFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIYWWG" tRNA 9979..10046 /product="tRNA-Gly" gene 10047..10392 /gene="ND3" CDS 10047..10392 /gene="ND3" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:10392,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 3" /protein_id="AAO88703.1" /db_xref="GI:29690848" /translation="MNFALILMINTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPM SPARVPFSMKFFLVAITFLLFDLEIALLLPLPWALQTTNLPLMVMSSLLLIIILALSL AYEWLQKGLDWAE" tRNA 10393..10457 /product="tRNA-Arg" gene 10458..10754 /gene="ND4L" CDS 10458..10754 /gene="ND4L" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 4L" /protein_id="AAO88704.1" /db_xref="GI:29690849" /translation="MPLIYMNIMLAFTISLLGMLVYRSHLMSSLLCLEGMMLSLFIMA TLMTLNTHSLLANIVPIAMLVFAACEAAVGLALLVSISNTYGLDYVHNLNLLQC" gene 10748..12125 /gene="ND4" CDS 10748..12125 /gene="ND4" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:12125,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 4" /protein_id="AAO88705.1" /db_xref="GI:29690850" /translation="MLKLIVPTIMLLPLTWLSKKHMIWINTTTHSLIISIIPLLFFNQ INNNLFSCSPTFSSDPLTTPLLMLTTWLLPLTIMASQRHLSSEPLSRKKLYLSMLISL QISLIMTFTATELIMFYIFFETTLIPTLAIITRWGNQPERLNAGTYFLFYTLVGSLPL LIALIYTHNTLGSLNILLLTLTAQELSNSWANNLMWLAYTMAFMVKMPLYGLHLWLPK AHVEAPIAGSMVLAAVLLKLGGYGMMRLTLILNPLTKHMAYPFLVLSLWGMIMTSSIC LRQTDLKSLIAYSSISHMALVVTAILIQTPWSFTGAVILMIAHGLTSSLLFCLANSNY ERTHSRIMILSQGLQTLLPLMAFWWLLASLANLALPPTINLLGELSVLVTTFSWSNIT LLLTGLNMLVTALYSLYMFTTTQWGSLTHHINNMKPSFTRENTLMFMHLSPILLLSLN PDIITGFSS" tRNA 12126..12194 /product="tRNA-His" tRNA 12195..12253 /product="tRNA-Ser" tRNA 12254..12324 /product="tRNA-Leu" gene 12325..14136 /gene="ND5" CDS 12325..14136 /gene="ND5" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 5" /protein_id="AAO88706.1" /db_xref="GI:29690851" /translation="MTMHTTMTTLTLTSLIPPILTTLVNPNKKNSYPHYVKSIVASTF IISLFPTTMFMCLDQEVIISNWHWATTQTTQLSLSFKLDYFSMMFIPVALFVTWSIME FSLWYMNSDPNINQFFKYLLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLISWWYA RADANTAAIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLNANPSLTPLLGLLL AAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGVFLLIRFHPLAENSPLIQTL TLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMVVTIGINQPHLAFLHICTHAF FKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSK DHIIETANMSYTNAWALSITLIATSLTSAYSTRMILLTLTGQPRFPTLTNINENNPTL LNPIKRLAAGSLFAGFLITNNISPASPFQTTIPLYLKLTALAVTFLGLLTALDLNYLT NKLKMKSPLCTFYFSNMLGFYPSITHRTIPYLGLLTSQNLPLLLLDLTWLEKLLPKTI SQHQISTSIITSTQKGMIKLYFLSFFFPLILTLLLIT" gene complement(14137..14661) /gene="ND6" CDS complement(14137..14661) /gene="ND6" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 6" /protein_id="AAO88707.1" /db_xref="GI:29690852" /translation="MMYALFLLSVGLVMGFVGFSSKPSPIYGGLVLIVSGVVGCVIIL NFGGGYMGLMVFLIYLGGMMVVFGYTTAMAIEEYPEAWGSGVEVLVSVLVGLAMEVGL VLWVKEYDGVVVVVNFNSVGSWMIYEGEGSGLIREDPIGAGALYDYGRWLVVVTGWTL FVGVYIVIEIARGN" tRNA complement(14662..14730) /product="tRNA-Glu" gene 14735..15869 /gene="cytb" CDS 14735..15869 /gene="cytb" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:15869,aa:TERM) /transl_table=2 /product="cytochrome b" /protein_id="AAO88708.1" /db_xref="GI:29690853" /translation="MTPMRKINPLMKLINHSFIDLPTPSNISAWWNFGSLLGACLILQ ITTGLFLAMHYSPDASTAFSSIAHITRDVNYGWIIRYLHANGASMFFICLFLHIGRGL YYGSFLYSETWNIGIILLLATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDL VQWIWGGYSVDSPTLTRFFTFHFILPFIIAALAALHLLFLHETGSNNPLGITSHSDKI TFHPYYTIKDALGLLLFLLSLMTLTLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLF AYTILRSVPNKLGGVLALLLSILILAMIPILHMSKQQSMMFRPLSQSLYWLLAADLLI LTWIGGQPVSYPFTIIGQVASVLYFTTILILMPTISLIENKMLK" tRNA 15876..15941 /product="tRNA-Thr" tRNA complement(15943..16011) /product="tRNA-Pro" ORIGIN 1 gatcacaggt ctatcaccct attaaccact cacgggagct ctccatgcat ttggtatttt 61 cgtctggggg gtgtgcacgc gatagcattg cgagacgctg gagccggagc accctatgtc 121 gcagtatctg tctttgattc ctgccccatc ccattattta tcgcacctac gttcaatatt 181 acaggcgaac atacctatta aagtgtgtta attaattaat gcttgtagga cataataata 241 acaattaaat gtctgcacag ccactttcca cacagacatc ataacaaaaa atttccacca 301 aaccccccct ccccccgctt ctggccacag cacttaaaca catctctgcc aaaccccaaa 361 aacaaagaac cctaacacca gcctaaccag atttcaaatt ttatcttttg gcggtatgca 421 cttttaacag tcacccccca actaacacat tattttcccc tcccactccc atactactaa 481 tctcatcaat acaaccccgc ccatcctacc cagcacacac accgctgcta accccatacc 541 ccgaaccaac caaaccccaa agacaccccc cacagtttat gtagcttacc tccttaaagc 601 aatacactga aaatgtttag acgggctcac atcaccccat aaacaaatag gtttggtcct 661 agcctttcta ttagctctta gtaagattac acatgcaagc atccccgttc cagtgagttc 721 accctctaaa tcaccacgat caaaagggac aagcatcaag cacgcaacaa tgcagctcaa 781 aacgcttagc ctagccacac ccccacggga aacagcagtg ataaaccttt agcaataaac 841 gaaagtttaa ctaagctata ctaaccccag ggttggtcaa tttcgtgcca gccaccgcgg 901 tcacacgatt aacccaagtc aatagaagcc ggcgtaaaga gtgttttaga tcaccccctc 961 cccaataaag ctaaaactca cctgagttgt aaaaaactcc agttgacaca aaataaacta 1021 cgaaagtggc tttaacatat ctgaatacac aatagctaag acccaaactg ggattagata 1081 ccccactatg cttagcccta aacctcaaca gttaaatcaa caaaactgct cgccagaaca 1141 ctacgagcca cagcttaaaa ctcaaaggac ctggcggtgc ttcatatccc tctagaggag 1201 cctgttctgt aatcgataaa ccccgatcaa cctcaccacc tcttgctcag cctatatacc 1261 gccatcttca gcaaaccctg atgaaggcta caaagtaagc gcaagtaccc acgtaaagac 1321 gttaggtcaa ggtgtagccc atgaggtggc aagaaatggg ctacattttc taccccagaa 1381 aactacgata gcccttatga aacttaaggg tcgaaggtgg atttagcagt aaactaagag 1441 tagagtgctt agttgaacag ggccctgaag cgcgtacaca ccgcccgtca ccctcctcaa 1501 gtatacttca aaggacattt aactaaaacc cctacgcatt tatatagagg agacaagtcg 1561 taacatggta agtgtactgg aaagtgcact tggacgaacc agagtgtagc ttaacacaaa 1621 gcacccaact tacacttagg agatttcaac ttaacttgac cgctctgagc taaacctagc 1681 cccaaaccca ctccacctta ctaccagaca accttagcca aaccatttac ccaaataaag 1741 tataggcgat agaaattgaa acctggcgca atagatatag taccgcaagg gaaagatgaa 1801 aaattataac caagcataat atagcaagga ctaaccccta taccttctgc ataatgaatt 1861 aactagaaat aactttgcaa ggagagccaa agctaagacc cccgaaacca gacgagctac 1921 ctaagaacag ctaaaagagc acacccgtct atgtagcaaa atagtgggaa gatttatagg 1981 tagaggcgac aaacctaccg agcctggtga tagctggttg tccaagatag aatcttagtt 2041 caactttaaa tttgcccaca gaaccctcta aatccccttg taaatttaac tgttagtcca 2101 aagaggaaca gctctttgga cactaggaaa aaaccttgta gagagagtaa aaaatttaac 2161 acccatagta ggcctaaaag cagccaccaa ttaagaaagc gttcaagctc aacacccact 2221 acctaaaaaa tcccaaacat ataactgaac tcctcacacc caattggacc aatctatcac 2281 cctatagaag aactaatgtt agtataagta acatgaaaac attctcctcc gcataagcct 2341 gcgtcagatt aaaacactga actgacaatt aacagcccaa tatctacaat caaccaacaa 2401 gtcattatta ccctcactgt caacccaaca caggcatgct cataaggaaa ggttaaaaaa 2461 agtaaaagga actcggcaaa tcttaccccg cctgtttacc aaaaacatca cctctagcat 2521 caccagtatt agaggcaccg cctgcccagt gacacatgtt taacggccgc ggtaccctaa 2581 ccgtgcaaag gtagcataat cacttgttcc ttaaataggg acctgtatga atggctccac 2641 gagggttcag ctgtctctta cttttaacca gtgaaattga cctgcccgtg aagaggcggg 2701 catgacacag caagacgaga agaccctatg gagctttaat ttattaatgc aaacaatacc 2761 taacaaaccc acaggtccta aactaccaaa cctgcattaa aaatttcggt tggggcgacc 2821 tcggagcaga acccaacctc cgagcagtac atgctaagac ttcaccagtc aaagcgaact 2881 accatactca attgatccaa taacttgacc aacggaacaa gttaccctag ggataacagc 2941 gcaatcctat tctagagtcc atatcaacaa tagggtttac gacctcgatg ttggatcagg 3001 acatcccgat ggtgcagccg ctattaaagg ttcgtttgtt caacgattaa agtcctacgt 3061 gatctgagtt cagaccggag taatccaggt cggtttctat ctacttcaaa ttcctccctg 3121 tacgaaagga caagagaaat aaggcctact tcacaaagcg ccttcccccg taaatgatat 3181 catctcaact tagtattata cccacaccca cccaagaaca gggtttgtta agatggcaga 3241 gcccggtaat cgcataaaac ttaaaacttt acagtcagag gttcaattcc tcttcttaac 3301 aacataccca tggccaacct cctactcctc attgtaccca ttctaatcgc aatggcattc 3361 ctaatgctta ccgaacgaaa aattctaggc tatatacaac tacgcaaagg ccccaacgtt 3421 gtaggcccct acgggctact acaacccttc gctgacgcca taaaactctt caccaaagag 3481 cccctaaaac ccgccacatc taccatcacc ctatacatca ccgccccgac cttagctctc 3541 accatcgctc ttctactatg aacccccctc cccataccca accccctggt taacctcaac 3601 ctaggcctcc tatttattct agccacctct agcctagccg tttactcaat cctctgatca 3661 gggtgagcat caaactcaaa ctacgccctg atcggcgcac tgcgagcagt agcccaaaca 3721 atctcatatg aagtcaccct agccatcatt ctgctatcaa cattactaat aagtggctcc 3781 tttaacctct ccacccttat cacaacacaa gaacacctct gattactcct gccatcatga 3841 cccttggcca taatatgatt tatctccaca ctagcagaga ccaaccgaac ccccttcgac 3901 cttgccgaag gggagtccga actagtctca ggcttcaaca tcgaatacgc cgcaggcccc 3961 ttcgccctat tcttcatggc cgaatacaca aacattatta taataaacac cctcaccact 4021 ataatcttcc taggaacaac gtatgacgca ctctcccctg aactctacac aacatatttt 4081 gttaccaaga ccctacttct gacctccctg ttcttatgaa ttcgaacagc atacccccga 4141 ttccgctacg accaactcat acacctccta tgaaaaaact tcctaccact caccctagca 4201 ttacttatat gatatgtctc cgtacccact acaatctcca gcattccccc tcaaacctaa 4261 gaaatatgtc tgataaaaga gttactttga tagagtaaat aataggagtt taaaccccct 4321 tatttctagg actatgagaa tcgaacccat ccctgagaat ccaaaattct ccgtgccacc 4381 tatcacaccc catcctaaag taaggtcagc taaataagct atcgggccca taccccgaaa 4441 atgttggtta tacccttccc gtactaatta atcccctggc ccaacccgtc atctactcta 4501 ccatctttgc aggcacactc atcacagcgc taagctcgca ctgatttttt acctgagtag 4561 gcctagaaat aaacatgcta gcttttattc cagttctaac caaaaaaata aaccctcgtt 4621 ccacagaagc tgccatcaag tatttcctca cgcaagcaac cgcatccata atccttctaa 4681 tagctatcct cttcaacaat atactctccg gacaatgaac cataaccaat actaccaatc 4741 aatactcatc attaataatc ataatggcta tagcaataaa actaggaata gccccctttc 4801 acttctgagt cccagaggtt acccaaggca cccctctgac atccggcctg cttcttctca 4861 catgacaaaa actagccccc atctcaatca tataccaaat ctctccctca ctaaacgtaa 4921 gccttctcct cactctctca atcttatcca tcatagcagg cagttgaggt ggattaaacc 4981 aaacccagct acgcaaaatc ttagcatact cctcaattac ccacatagga tgaataatag 5041 cagttctacc gtacaaccct aacataacca ttcttaattt aactatttat attatcctaa 5101 ctactaccgc attcctacta ctcaacttaa actccagcac cacgaccctg ctactatctc 5161 gcacctgaaa caagctaaca tgactaacac ccttaattcc atccaccctc ctctccctag 5221 gaggcctgcc cccgctaacc ggctttttgc ccaaatgggc cattatcgaa gaattcacaa 5281 aaaacaatag cctcatcatc cccaccatca tagccaccat caccctcctt aacctctact 5341 tctacctacg cctaatctac tccacctcaa tcacactact ccccatatct aacaacgtaa 5401 aaataaaatg acagtttgaa catacaaaac ccaccccact cctccccaca ctcatcgccc 5461 ttaccacgct actcctacct atctcccctt ttatactaat aatcttatag aaatttaggt 5521 taaatacaga ccaagagcct tcaaagccct cagtaagttg caatacttaa tttctgtaac 5581 agctaaggac tgcaaaaccc cactctgcat caactgaacg caaatcagcc actttaatta 5641 agctaagccc ttactagacc aatgggactt aaacccacaa acacttagtt aacagctaag 5701 caccctaatc aactggcttc aatctacttc tcccgccgcc gggaaaaaag gcgggagaag 5761 ccccggcagg tttgaagctg cttcttcgaa tttgcaattc aatatgaaaa tcacctcgga 5821 gctggtaaaa agaggcctaa cccctgtctt tagatttaca gtccaatgct tcactcagcc 5881 attttacctc acccccactg atgttcgccg accgttgact attctctaca aaccacaaag 5941 acattggaac actataccta ttattcggcg catgagctgg agtcctaggc acagctctaa 6001 gcctccttat tcgagccgag ctgggccagc caggcaacct tctaggtaac gaccacatct 6061 acaacgttat cgtcacagcc catgcatttg taataatctt cttcatagta atacccatca 6121 taatcggagg ctttggcaac tgactagttc ccctaataat cggtgccccc gatatggcgt 6181 tcccccgcat aaacaacata agcttctgac tcttacctcc ctctctccta ctcctgctcg 6241 catctgctat agtggaggcc ggagcaggaa caggttgaac agtctaccct cccttagcag 6301 ggaactactc ccaccctgga gcctccgtag acctaaccat cttctcctta cacctagcag 6361 gtgtctcctc tatcttaggg gccatcaatt tcatcacaac aattatcaat ataaaacccc 6421 ctgccataac ccaataccaa acgcccctct tcgtctgatc cgtcctaatc acagcagtcc 6481 tacttctcct atctctccca gtcctagctg ctggcatcac tatactacta acagaccgca 6541 acctcaacac caccttcttc gaccccgccg gaggaggaga ccccattcta taccaacacc 6601 tattctgatt tttcggtcac cctgaagttt atattcttat cctaccaggc ttcggaataa 6661 tctcccatat tgtaacttac tactccggaa aaaaagaacc atttggatac ataggtatgg 6721 tctgagctat gatatcaatt ggcttcctag ggtttatcgt gtgagcacac catatattta 6781 cagtaggaat agacgtagac acacgagcat acttcacctc cgctaccata atcatcgcta 6841 tccccaccgg cgtcaaagta tttagctgac tcgccacact ccacggaagc aatatgaaat 6901 gatctgctgc agtgctctga gccctaggat tcatctttct tttcaccgta ggtggcctga 6961 ctggcattgt attagcaaac tcatcactag acatcgtact acacgacacg tactacgttg 7021 tagctcactt ccactatgtc ctatcaatag gagctgtatt tgccatcata ggaggcttca 7081 ttcactgatt tcccctattc tcaggctaca ccctagacca aacctacgcc aaaatccatt 7141 tcgctatcat gttcatcggc gtaaatctaa ctttcttccc acaacacttt ctcggcctat 7201 ccggaatgcc ccgacgttac tcggactacc ccgatgcata caccacatga aatatcctat 7261 catctgtagg ctcattcatt tctctaacag cagtaatatt aataattttc atgatttgag 7321 aagccttcgc ttcgaagcga aaagtcctaa tagtagaaga accctccata aacctggagt 7381 gactatatgg atgcccccca ccctaccaca cattcgaaga acccgtatac ataaaatcta 7441 gacaaaaaag gaaggaatcg aaccccccaa agctggtttc aagccaaccc catggcctcc 7501 atgacttttt caaaaagata ttagaaaaac catttcataa ctttgtcaaa gttaaattat 7561 aggctaaatc ctatatatct taatggcaca tgcagcgcaa gtaggtctac aagacgctac 7621 ttcccctatc atagaagagc ttatcacctt tcatgatcac gccctcataa tcattttcct 7681 tatctgcttc ctagtcctgt atgccctttt cctaacactc acaacaaaac taactaatac 7741 taacatctca gacgctcagg aaatagaaac cgtctgaact atcctgcccg ccatcatcct 7801 agtcctcatc gccctcccat ccctacgcat cctttacata acagacgagg tcaacgatcc 7861 ctcccttacc atcaaatcaa ttggccacca atggtactga acctacgagt acaccgacta 7921 cggcggacta atcttcaact cctacatact tcccccatta ttcctagaac caggcgacct 7981 gcgactcctt gacgttgaca atcgagtagt actcccgatt gaagccccca ttcgtataat 8041 aattacatca caagacgtct tgcactcatg agctgtcccc acattaggct taaaaacaga 8101 tgcaattcca ggacgtctaa accaaaccac tttcaccgct acacgaccag gggtatacta 8161 cggtcaatgc tctgaaatct gtggagcaaa ccacagtttc atgcccatcg tcctagaatt 8221 aattccccta aaaatctttg aaataggacc cgtatttacc ctatagtacc ccctctagag 8281 cccactgtaa agctaactta gcattaacct tttaagttaa agattaagag aaccaacacc 8341 tctttacagt gaaatgcccc aactaaatac taccgtatga cccaccataa ttacccccat 8401 actccttaca ctattcctca tcacccaact aaaaatatta aacacaaact accacttacc 8461 tccctcacca aagcccataa aaataaaaaa ttataacaaa ccctgagaac caaaatgaac 8521 gaaaatctgt tcacttcatt cattgccccc acaatcctag gcctacccgc cgcagtactg 8581 atcattctat ttccccctct attgatcccc acctccaaat atctcatcaa caaccgacta 8641 attaccaccc aacaatgact aatcaaacta acctcaaaac aaatgatagc catacacaac 8701 actaaaggac gaacctgatc tcttatacta gtatccttaa tcatttttat tgccacaact 8761 aacctcctcg gactcctgcc tcactcattt acaccaacca cccaactatc tataaaccta 8821 gccatggcca tccccttatg agcgggcgca gtgattatag gctttcgctc taagattaaa 8881 aatgccctag cccacttctt accacaaggc acacctacac cccttatccc catactagtt 8941 attatcgaaa ccatcagcct actcattcaa ccaatagccc tggccgtacg cctaaccgct 9001 aacattactg caggccacct actcatgcat ctaattggaa gcgccaccct agcaatatca 9061 accattaacc ttccctctac acttatcatc ttcacaattc taattctact gactatccta 9121 gaaatcgctg tcgccttaat ccaagcctac gttttcacac ttctagtaag cctctacctg 9181 cacgacaaca cataatgacc caccaatcac atgcctatca tatagtaaaa cccagcccat 9241 gacccctaac aggggccctc tcagccctcc taatgacctc cggcctagcc atgtgatttc 9301 acttccactc cataacgctc ctcatactag gcctgctaac caacacacta accatatacc 9361 aatgatggcg cgatgtaaca cgagaaagca cataccaagg ccaccacaca ccacctgtcc 9421 aaaaaggcct tcgatacggg ataatcctat ttattacctc agaagttttt ttcttcgcag 9481 gatttttctg agccttttac cactccagcc tagcccctac cccccaacta ggagggcact 9541 ggcccccaac aggcatcacc ccgctaaatc ccctagaagt cccactccta aacacatccg 9601 tattactcgc atcaggagta tcaatcacct gagctcacca tagtctaata gaaaacaacc 9661 gaaaccaaat aattcaagca ctgcttatta caattttact gggtctctat tttaccctcc 9721 tacaagcctc agagtacttc gaatctccct tcaccatttc cgacggcatc tacggctcaa 9781 cattttttgt agccacaggc ttccacggac ttcacgtcat tattggctca actttcctca 9841 ctatctgctt catccgccaa ctaatatttc actttacatc caaacatcac tttggcttcg 9901 aagccgccgc ctgatactgg cattttgtag atgtggtttg actatttctg tatgtctcca 9961 tctattgatg agggtcttac tcttttagta taaatagtac cgttaacttc caattaacta 10021 gttttgacaa cattcaaaaa agagtaataa acttcgcctt aattttaata atcaacaccc 10081 tcctagcctt actactaata attattacat tttgactacc acaactcaac ggctacatag 10141 aaaaatccac cccttacgag tgcggcttcg accctatatc ccccgcccgc gtccctttct 10201 ccataaaatt cttcttagta gctattacct tcttattatt tgatctagaa attgccctcc 10261 ttttacccct accatgagcc ctacaaacaa ctaacctgcc actaatagtt atgtcatccc 10321 tcttattaat catcatccta gccctaagtc tggcctatga gtgactacaa aaaggattag 10381 actgagccga attggtatat agtttaaaca aaacgaatga tttcgactca ttaaattatg 10441 ataatcatat ttaccaaatg cccctcattt acataaatat tatactagca tttaccatct 10501 cacttctagg aatactagta tatcgctcac acctcatatc ctccctacta tgcctagaag 10561 gaataatact atcgctattc attatagcta ctctcataac cctcaacacc cactccctct 10621 tagccaatat tgtgcctatt gccatactag tttttgccgc ctgcgaagca gcggtaggcc 10681 tagccctact agtctcaatc tccaacacat atggcctaga ctacgtacat aacctaaacc 10741 tactccaatg ctaaaactaa tcgtcccaac aattatatta ctaccactga catgactctc 10801 caaaaaacac ataatttgaa tcaacacaac cacccacagc ctaattatta gcatcatccc 10861 cctactattt tttaaccaaa tcaacaacaa cctatttagc tgctccccaa ccttttcctc 10921 cgacccccta acaacccccc tcctaatact aactacctga ctcctacccc tcacaatcat 10981 ggcaagccaa cgccacttat ccagtgaacc actatcacga aaaaaactct acctctctat 11041 actaatctcc ctacaaatct ccttaattat aacattcaca gccacagaac taatcatatt 11101 ttatatcttc ttcgaaacca cacttatccc caccttggct atcatcaccc gatgaggcaa 11161 ccagccagaa cgcctgaacg caggcacata cttcctattc tacaccctag taggctccct 11221 tcccctactc atcgcactaa tttacactca caacacccta ggctcactaa acattctact 11281 actcactctc actgcccaag aactatcaaa ctcctgagcc aacaacttaa tatgactagc 11341 ttacacaata gcttttatag taaagatacc tctttacgga ctccacttat gactccctaa 11401 agcccatgtc gaagccccca tcgctgggtc aatagtactt gccgcagtac tcttaaaact 11461 aggcggctat ggtataatac gcctcacact cattctcaac cccctgacaa aacacatagc 11521 ctaccccttc cttgtactat ccctatgagg cataattata acaagctcca tctgcctacg 11581 acaaacagac ctaaaatcgc tcattgcata ctcttcaatc agccacatag ccctcgtagt 11641 aacagccatt ctcatccaaa ccccctgaag cttcaccggc gcagtcattc tcataatcgc 11701 ccacggactt acatcctcat tactattctg cctagcaaac tcaaactacg aacgcactca 11761 cagtcgcatc ataatcctct ctcaaggact tcaaactcta ctcccactaa tagctttttg 11821 atgacttcta gcaagcctcg ccaacctcgc cttacccccc actattaacc tactgggaga 11881 actctctgtg ctagtaacca cattctcctg atcaaatatc actctcctac ttacaggact 11941 caacatacta gtcacagccc tatactccct ctacatattt accacaacac aatgaggctc 12001 actcacccac cacattaaca acataaaacc ctcattcaca cgagaaaaca ccctcatgtt 12061 catacaccta tcccccattc tcctcctatc cctcaacccc gacatcatca ccgggttttc 12121 ctcttgtaaa tatagtttaa ccaaaacatc agattgtgag tctgacaaca gaggcttacg 12181 accccttatt taccgagaaa gctcacaaga actgctaact cgtgccccca tgtctaacaa 12241 catggctttc tcaactttta aaggataaca gctatccatt ggtcttaggc cccaaaaatt 12301 ttggtgcaac tccaaataaa agtaataacc atgcacacta ctataaccac cctaaccctg 12361 acttccctaa ttccccccat ccttaccacc ctcgttaacc ctaacaaaaa aaactcatac 12421 ccccattatg taaaatccat tgtcgcatcc acctttatta tcagtctctt ccccacaaca 12481 atattcatgt gcctagacca agaagttatt atctcgaact gacactgagc cacaacccaa 12541 acaacccagc tctccctaag cttcaaacta gactacttct ccataatatt catccctgta 12601 gcattgttcg ttacatggtc catcatagaa ttctcactgt gatatataaa ctcagaccca 12661 aacattaatc agttcttcaa atatctactc attttcctaa ttaccatgct aatcttagtt 12721 accgctaaca acctattcca actgttcatc ggctgagagg gcgtaggaat tatatccttc 12781 ttgctcatca gttgatggta cgcccgagca gatgccaaca cagcagccat tcaagcaatc 12841 ctatacaacc gtatcggcga tatcggtttc atcctcgcct tagcatgatt tatcctacac 12901 tccaactcat gagacccaca acaaatagcc cttctaaacg ctaatccaag cctcacccca 12961 ctactaggcc tcctcctagc agcagcaggc aaatcagccc aattaggtct ccacccctga 13021 ctcccctcag ccatagaagg ccccacccca gtctcagccc tactccactc aagcactata 13081 gttgtagcag gagtcttctt actcatccgc ttccaccccc tagcagaaaa tagcccacta 13141 atccaaactc taacactatg cttaggcgct atcaccactc tgttcgcagc agtctgcgcc 13201 cttacacaaa atgacatcaa aaaaatcgta gccttctcca cttcaagtca actaggactc 13261 atagtagtta caatcggcat caaccaacca cacctagcat tcctgcacat ctgtacccac 13321 gccttcttca aagccatact atttatgtgc tccgggtcca tcatccacaa ccttaacaat 13381 gaacaagata ttcgaaaaat aggaggacta ctcaaaacca tacctctcac ttcaacctcc 13441 ctcaccattg gcagcctagc attagcagga atacctttcc tcacaggttt ctattccaaa 13501 gaccacatca tcgaaaccgc aaacatatca tacacaaacg cctgagccct atctattact 13561 ctcatcgcta cctccctgac aagcgcctat agcactcgaa taattcttct caccctaaca 13621 ggtcaacctc gcttccctac ccttactaac attaacgaaa ataaccccac cctactaaac 13681 cccattaaac gcctggcagc cggaagccta ttcgcaggat ttctcattac taacaacatt 13741 tcccccgcat cccccttcca aacaacaatc cccctctacc taaaactcac agccctcgct 13801 gtcactttcc taggacttct aacagcccta gacctcaact acctaaccaa caaacttaaa 13861 ataaaatccc cactatgcac attttatttc tccaacatac tcggattcta ccctagcatc 13921 acacaccgca caatccccta tctaggcctt cttacgagcc aaaacctgcc cctactcctc 13981 ctagacctaa cctgactaga aaagctatta cctaaaacaa tttcacagca ccaaatctcc 14041 acctccatca tcacctcaac ccaaaaaggc ataattaaac tttacttcct ctctttcttc 14101 ttcccactca tcctaaccct actcctaatc acataaccta ttcccccgag caatctcaat 14161 tacaatatat acaccaacaa acaatgttca accagtaact actactaacc aacgcccata 14221 atcatacaaa gcccccgcac caataggatc ctcccgaatc aaccctgacc cctctccttc 14281 ataaattatt cagcttccta cactattaaa gtttaccaca accaccaccc catcatactc 14341 tttcac