LOCUS AY195769 16575 bp DNA circular PRI 10-JUN-2004 DEFINITION Homo sapiens haplotype E22i mitochondrion, complete genome. ACCESSION AY195769 VERSION AY195769.2 GI:48596177 KEYWORDS . SOURCE mitochondrion Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 16575) AUTHORS Mishmar,D., Ruiz-Pesini,E., Golik,P., Macaulay,V., Clark,A.G., Hosseini,S., Brandon,M., Easley,K., Chen,E., Brown,M.D., Sukernik,R.I., Olckers,A. and Wallace,D.C. TITLE Natural selection shaped regional mtDNA variation in humans JOURNAL Proc. Natl. Acad. Sci. U.S.A. 100 (1), 171-176 (2003) MEDLINE 22406325 PUBMED 12509511 REFERENCE 2 (bases 1 to 16575) AUTHORS Mishmar,D., Ruiz-Pesini,E., Golik,P., Macaulay,V., Clark,A.G., Hosseini,S., Brandon,M., Easley,K., Chen,E., Brown,M.D., Sukernik,R.I., Olckers,A. and Wallace,D.C. TITLE Direct Submission JOURNAL Submitted (11-DEC-2002) MAMMAG, University of California, Irvine, 2nd Floor Hewitt Hall, Irvine, California 92697-3940, USA REFERENCE 3 (bases 1 to 16575) AUTHORS Mishmar,D., Ruiz-Pesini,E., Golik,P., Macaulay,V., Clark,A.G., Hosseini,S., Brandon,M., Easley,K., Chen,E., Brown,M.D., Sukernik,R.I., Olckers,A. and Wallace,D.C. TITLE Direct Submission JOURNAL Submitted (10-JUN-2004) MAMMAG, University of California, Irvine, 2nd Floor Hewitt Hall, Irvine, California 92697-3940, USA REMARK Sequence update by submitter COMMENT On Jun 10, 2004 this sequence version replaced gi:29690728. FEATURES Location/Qualifiers source 1..16575 /organism="Homo sapiens" /organelle="mitochondrion" /mol_type="genomic DNA" /isolation_source="I haplogroup" /db_xref="taxon:9606" /haplotype="E22i" D-loop complement(join(16110..16575,1..191)) tRNA 584..654 /product="tRNA-Phe" rRNA 655..1607 /product="12S ribosomal RNA" tRNA 1608..1676 /product="tRNA-Val" rRNA 1677..3234 /product="16S ribosomal RNA" tRNA 3235..3309 /product="tRNA-Leu" gene 3312..4268 /gene="ND1" CDS 3312..4268 /gene="ND1" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 1" /protein_id="AAO88592.1" /db_xref="GI:29690729" /translation="MPMANLLLLIVPILIAMAFLMLTERKILGYMQLRKGPNVVGPYG LLQPFADAMKLFTKEPLKPATSTITLYITAPTLALTIALLLWTPLPMPNPLVNLNLGL LFILATSSLAVYSILWSGWASNSNYALIGALRAVAQTISYEVTLAIILLSTLLMSGSF NLSTLITTQEHLWLLLPSWPLAMMWFISTLAETNRTPFDLAEGESELVSGFNIEYAAG PFALFFMAEYTNIIMMNTLTTTIFLGTTYDALSPELYTTYFVTKTLLLTSLFLWIRTA YPRFRYDQLMHLLWKNFLPLTLALLMWYVSMPITISSIPPQT" tRNA 4268..4336 /product="tRNA-Ile" tRNA complement(4334..4405) /product="tRNA-Gln" tRNA 4407..4474 /product="tRNA-Met" gene 4475..5518 /gene="ND2" CDS 4475..5518 /gene="ND2" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 2" /protein_id="AAO88593.1" /db_xref="GI:29690730" /translation="MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVL TKKMNPRSTEAAIKYFLTQATASMILLMAILFNNMLSGQWTMTNTTNQYSSLMIMMAM AMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPSLNVSLLLTLSIL SIMAGSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLL LNLNSSTTTLLLSRTWNKLTWLTPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSL IIPTIMATITLLNLYFYLRLIYSTSITLLPMSNNVKMKWQFEHTKPTPFLPTLIALTT LLLPISPFMLMIL" tRNA 5517..5584 /product="tRNA-Trp" tRNA complement(5592..5660) /product="tRNA-Ala" tRNA complement(5662..5734) /product="tRNA-Asn" tRNA complement(5766..5831) /product="tRNA-Cys" tRNA complement(5831..5896) /product="tRNA-Tyr" gene 5909..7450 /gene="COX1" CDS 5909..7450 /gene="COX1" /codon_start=1 /transl_table=2 /product="cytochrome oxidase subunit I" /protein_id="AAO88594.1" /db_xref="GI:29690731" /translation="MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQP GNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSF WLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILG AINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTT FFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWA MMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKW SAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGG FIHWFPLFSGYTLDQTYAKIHFTIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTW NILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEEP VYMKS" tRNA complement(7450..7522) /product="tRNA-Ser" tRNA 7524..7591 /product="tRNA-Asp" gene 7592..8275 /gene="COX2" CDS 7592..8275 /gene="COX2" /codon_start=1 /transl_table=2 /product="cytochrome oxidase subunit II" /protein_id="AAO88595.1" /db_xref="GI:29690732" /translation="MAHAAQVGLQDATSPIMEELITFHDHALMIIFLICFLVLYALFL TLTTKLTNTNISDAQEMETVWTILPAIILVLIALPSLRILYMTDEVNDPSLTIKSIGH QWYWTYEYTDYGGLIFNSYMLPPLFLEPGDLRLLDVDNRVVLPIEAPIRMMITSQDVL HSWAVPTLGLKTDAIPGRLNQTTFTATRPGVYYGQCSEICGANHSFMPIVLELIPLKI FEMGPVFTL" tRNA 8301..8370 /product="tRNA-Lys" gene 8372..8578 /gene="ATP8" CDS 8372..8578 /gene="ATP8" /codon_start=1 /transl_table=2 /product="ATP synthase F0 subunit 8" /protein_id="AAO88596.1" /db_xref="GI:29690733" /translation="MPQLNTTVWPTMITPMLLTLFLITQLKMLNTNYHLPPSPKPMKM KNYNKPWEPKWTKICSLHSLPPQS" gene 8533..9213 /gene="ATP6" CDS 8533..9213 /gene="ATP6" /codon_start=1 /transl_table=2 /product="ATP synthase F0 subunit 6" /protein_id="AAO88597.1" /db_xref="GI:29690734" /translation="MNENLFASFIAPTILGLPAAVLIILFPPLLIPTSKYLINNRLIT TQQWLIKLTSKQMMTMHNTKGRTWSLMLVSLIIFIATTNLLGLLPHSFTPTTQLSMNL AMAIPLWAGAVIMGFRSKIKNALAHFLPQGTPTPLIPMLVIIETISLLIQPMALAVRL TANITAGHLLMHLIGSATLAMSTINLPSTLIIFTILILLTILEIAVALIQAYVFTLLV SLYLHDNT" gene 9213..9993 /gene="COX3" CDS 9213..9993 /gene="COX3" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:9993,aa:TERM) /transl_table=2 /product="cytochrome oxidase subunit III" /protein_id="AAO88598.1" /db_xref="GI:29690735" /translation="MTHQSHAYHMVKPSPWPLTGALSALLMTSGLAMWFHFHSMTLLM LGLLTNTLTMYQWWRDVTRESTYQGHHTPPVQKGLRYGMVLFITSEVFFFAGFFWAFY HSSLAPTPQLGGHWPPTGITPLNPLEVPLLNTSVLLASGVSITWAHHSLMENNRNQMI QALLITILLGLYFTLLQASEYFESPFTISDGIYGSTFFVATGFHGLHVIIGSTFLTIC FIRQLMFHFTSKHHFGFEAAAWYWHFVDVVWLFLYISIYWWG" tRNA 9997..10064 /product="tRNA-Gly" gene 10065..10410 /gene="ND3" CDS 10065..10410 /gene="ND3" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:10410,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 3" /protein_id="AAO88599.1" /db_xref="GI:29690736" /translation="MNFALILMINTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPM SPARVPFSMKFFLVAITFLLFDLEIALLLPLPWALQTTNLPLMVMSSLLLIIILALSL AYEWLQKGLDWAE" tRNA 10411..10475 /product="tRNA-Arg" gene 10476..10772 /gene="ND4L" CDS 10476..10772 /gene="ND4L" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 4L" /protein_id="AAO88600.1" /db_xref="GI:29690737" /translation="MPLIYMNIMLAFTISLLGMLVYRSHLMSSLLCLEGMMLSLFIMA TLMTLNTHSLLANIVPIAMLVFAACEAAVGLALLVSISNTYGLDYVHNLNLLQC" gene 10766..12143 /gene="ND4" CDS 10766..12143 /gene="ND4" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:12143,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 4" /protein_id="AAO88601.1" /db_xref="GI:29690738" /translation="MLKLIVPTIMLLPLTWLSKKHMIWINTTTHSLIISIIPLLFFNQ INNNLFSCSPTFSSDPLTTPLLMLTTWLLPLTIMASQRHLSSEPLSRKKLYLSMLISL QISLIMTFTATELIMFYIFFETTLIPTLAIITRWGNQPERLNAGTYFLFYTLVGSLPL LIALIYTHNTLGSLNILLLTLTAQELSNSWANNLMWLAYTMAFMVKMPLYGLHLWLPK AHVEAPIAGSMVLAAVLLKLGGYGMMRLTLILNPLTKHMAYPFLVLSLWGMIMTSSIC LRQTDLKSLIAYSSISHMALVVTAILIQTPWSFTGAVILMIAHGLTSSLLFCLANSNY ERTHSRIMILSQGLQTLLPLMAFWWLLASLANLALPPTINLLGELSVLVTTFSWSNIT LLLTGLNMLVTALYSLYMFTTTQWGSLTHHINNMKPSFTRENTLMFMHLSPILLLSLN PDIITGFSS" tRNA 12144..12212 /product="tRNA-His" tRNA 12213..12271 /product="tRNA-Ser" tRNA 12272..12342 /product="tRNA-Leu" gene 12343..14154 /gene="ND5" CDS 12343..14154 /gene="ND5" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 5" /protein_id="AAO88602.1" /db_xref="GI:29690739" /translation="MTMHTTMTTLTLTSLIPPILTTLVNPNKKNSYPHYVKSIVASTF IISLFPTTMFMCLDQEVIISNWHWATTQTTQLSLSFKLDYFSMMFIPVALFVTWSIME FSLWYMNSDPNINQFFKYLLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLISWWYA RADANTAAIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLNANPSLTPLLGLLL AAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFHPLAENSPLIQTL TLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAF FKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSK DHIIETANMSYTNAWALSITLIATSLTSAYSTRMILLTLTGQPRFPTLTNINENNPTL LNPIKRLAAGSLFAGFLITNNISPASPFQTTVPLYLKLTALAVTFLGLLTALDLNYLT NKLKMKSPLCTFYFSNMLGFYPSITHRTIPYLGLLTSQNLPLLLLDLTWLEKLLPKTI SQHQISTSIITSTQKGMIKLYFLSFFFPLILTLLLIT" gene complement(14155..14679) /gene="ND6" CDS complement(14155..14679) /gene="ND6" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 6" /protein_id="AAO88603.1" /db_xref="GI:29690740" /translation="MMYALFLLSVGLVMGFVGFSSKPSPIYGGLVLIVSGVVGCVIIL NFGGGYMGLMVFLIYLGGMMVVFGYTTAMAIEEYPEAWGSGVEVLVSVLVGLAMEVGL VLWVKEYDGVVVVVNFNSVGSWMIYEGEGSGLIREDPIGAGALYDYGRWLVVVTGWTL FVGVYIVIEIARGN" tRNA complement(14680..14748) /product="tRNA-Glu" gene 14753..15887 /gene="cytb" CDS 14753..15887 /gene="cytb" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:15887,aa:TERM) /transl_table=2 /product="cytochrome b" /protein_id="AAO88604.1" /db_xref="GI:29690741" /translation="MTPMRKINPLMKLINHSFIDLPTPSNISAWWNFGSLLGACLILQ ITTGLFLAMHYSPDASTAFSSIAHITRDVNYGWIIRYLHANGASMFFICLFLHIGRGL YYGSFLYSETWNIGIILLLATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDL VQWIWGGYSVDSPTLTRFFTFHFILPFIIAALAALHLLFLHETGSNNPLGITSHSDKI TFHPYYTIKDALGLLLFLLSLMTLTLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLF AYTILRSVPNKLGGVLALLLSILILAMIPILHMSKQQSMMFRPLSQSLYWLLAADLLI LTWIGGQPVSYPFTIIGQVASVLYFTTILILMPTISLIENKMLK" tRNA 15894..15959 /product="tRNA-Thr" tRNA complement(15961..16029) /product="tRNA-Pro" ORIGIN 1 gatcacaggt ctatcaccct attaaccact cacgggagct ctccatgcat ttggtatttt 61 cgtctggggg gtgtgcacgc gatagcattg cgagacgctg gagccggagc accctatgtc 121 gcagtatctg tctttgattc ctgcctcatc ctattattta tcgcacctac gttcaatatt 181 acaggcgaac atacttacca aagcgtgtta attaattaat gcttgtagga cataataata 241 acaattgaac gtctgcacag ccgctttcca cacagacatc ataacaaaaa atttccacca 301 aacccccccc tccccccgct tctggccaca gcacttaaac acatctctgc caaaccccaa 361 aaacaaagaa ccctaacacc agcctaacca gatttcaaat tttatctttt ggcggtatgc 421 acttttaaca gtcacccccc aactaacaca ttatttttcc cctcccactc ccatactact 481 aatctcatca atacaacccc cgcccatcct acccagcaca cacacaccgc tgctaacccc 541 ataccccgaa ccaaccaaac cccaaagaca cccccccccc acagtttatg tagcttacct 601 cctcaaagca atacactgaa aatgtttaga cgggctcaca tcaccccata aacaaatagg 661 tttggtccta gcctttctat tagctcttag taagattaca catgcaagca tccccgttcc 721 agtgagttca ccctctaaat caccacgatc aaaagggaca agcatcaagc acgcagcaat 781 gcagctcaaa acgcttagcc tagccacacc cccacgggaa acagcagtga ttaaccttta 841 gcaataaacg aaagtttaac taagctatac taaccccagg gttggtcaat ttcgtgccag 901 ccaccgcggt cacacgatta acccaagtca atagaagccg gcgtaaagag tgttttagat 961 caccccctcc caataaagct aaaactcacc tgagttgtaa aaaactccag ttgacacaaa 1021 atagactacg aaagtggctt taacatatct gaacacacaa tagctaagac ccaaactggg 1081 attagatacc ccactatgct tagccctaaa cctcaacagt taaatcaaca aaactgctcg 1141 ccagaacact acgagccaca gcttaaaact caaaggacct ggcggtgctt catatccctc 1201 tagaggagcc tgttctgtaa tcgataaacc ccgatcaacc tcaccacctc ttgctcagcc 1261 tatataccgc catcttcagc aaaccctgat gaaggctaca aagtaagcgc aagtacccac 1321 gtaaagacgt taggtcaagg tgtagcccat gaggtggcaa gaaatgggct acattttcta 1381 ccccagaaaa ctacgatagc ccttatgaaa cttaagggtc gaaggtggat ttagcagtaa 1441 actgagagta gagtgcttag ttgaacaggg ccctgaagcg cgtacacacc gcccgtcacc 1501 ctcctcaagt atacttcaaa ggacatttaa ctaaaacccc tacgcattta tatagaggag 1561 acaagtcgta acatggtaag tgtactggaa agtgcacttg gacgaaccag agtgtagctt 1621 aacacaaagc acccaactta cacttaggag atttcaactt aacttgaccg ctctgagcta 1681 aacctagccc caaacccact ccaccttact accagacaac cttaaccaaa ccatttaccc 1741 aaataaagta taggcgatag aaattgaaac ctggcgcaat agatatagta ccgcaaggga 1801 aagatgaaaa attataacca agcataatat agcaaggact aacccctata ccttctgcat 1861 aatgaattaa ctagaaataa ctttgcaagg agagccaaag ctaagacccc cgaaaccaga 1921 cgagctacct aagaacagct aaaagagcac acccgtctat gtagcaaaat agtgggaaga 1981 tttataggta gaggcgacaa acctaccgag cctggtgata gctggttgtc caagatagaa 2041 tcttagttca actttaaatt tgcccacaga accctctaaa tccccttgta aatttaactg 2101 ttagtccaaa gaggaacagc tctttggaca ctaggaaaaa accttgtaga gagagtaaaa 2161 aatttaacac ccatagtagg cctaaaagca gccaccaatt aagaaagcgt tcaagctcaa 2221 cacccactac ctaaaaaatc ccaaacatat aactgaactc ctcacaccca attggaccaa 2281 tctatcaccc tatagaagaa ctaatgttag tataagtaac atgaaaacat tctcctccgc 2341 ataagcctgc gtcagattaa aacactgaac tgacaattaa cagcccaata tctacaatca 2401 accaacaagt cattattacc ctcactgtca acccaacaca ggcatgctca taaggaaagg 2461 ttaaaaaaag taaaaggaac tcggcaaatc ttaccccgcc tgtttaccaa aaacatcacc 2521 tctagcatca ccagtattag aggcaccgcc tgcccagtga cacatgttta acggccgcgg 2581 taccctaacc gtgcaaaggt agcataatca cttgttcctt aaatagggac ctgtatgaat 2641 ggctccacga gggttcagct gtctcttact tttaaccagt gaaattgacc tgcccgtgaa 2701 gaggcgggca tgacacagca agacgagaag accctatgga gctttaattt attaatgcaa 2761 acagtaccta acaaacccac aggtcctaaa ctaccaaacc tgcattaaaa atttcggttg 2821 gggcgacctc ggagcagaac ccaacctccg agcagtacat gctaagactt caccagtcaa 2881 agcgaactac tatactcaat tgatccaata acttgaccaa cggaacaagt taccctaggg 2941 ataacagcgc aatcctattc tagagtccat atcaacaata gggtttacga cctcgatgtt 3001 ggatcaggac atcccgatgg tgcagccgct attaaaggtt cgtttgttca acgattaaag 3061 tcctacgtga tctgagttca gaccggagta atccaggtcg gtttctatct acttcaaatt 3121 cctccctgta cgaaaggaca agagaaataa ggcctacttc acaaagcgcc ttcccccgta 3181 aatgatatca tctcaactta gtattatacc cacacccacc caagaacagg gtttgttaag 3241 atggcagagc ccggtaatcg cataaaactt aaaactttac agtcagaggt tcaattcctc 3301 ttcttaacaa catacccatg gccaacctcc tactcctcat tgtacccatt ctaatcgcaa 3361 tggcattcct aatgcttacc gaacgaaaaa ttctaggcta tatacaacta cgcaaaggcc 3421 ccaacgttgt aggcccctac gggctactac aacccttcgc tgacgccata aaactcttca 3481 ccaaagagcc cctaaaaccc gccacatcta ccatcaccct ctacatcacc gccccgacct 3541 tagctctcac catcgctctt ctactatgaa cccccctccc catacccaac cccctggtca 3601 acctcaacct aggcctccta tttattctag ccacctctag cctagccgtt tactcaatcc 3661 tctgatcagg gtgagcatca aactcaaact acgccctgat cggcgcactg cgagcagtag 3721 cccaaacaat ctcatatgaa gtcaccctag ccatcattct actatcaaca ttactaataa 3781 gtggctcctt taacctctcc acccttatca caacacaaga acacctctga ttactcctgc 3841 catcatgacc cctggccata atatgattta tctccacact agcagagacc aaccgaaccc 3901 ccttcgacct tgccgaaggg gagtccgaac tagtctcagg cttcaacatc gaatacgccg 3961 caggcccctt cgccctattc ttcatagccg aatacacaaa cattattata ataaacaccc 4021 tcaccactac aatcttccta ggaacaacat atgacgcact ctcccctgaa ctctacacaa 4081 catattttgt caccaagacc ctacttctaa cctccctgtt cttatgaatt cgaacagcat 4141 acccccgatt ccgctacgac caactcatac acctcctatg aaaaaacttc ctaccactca 4201 ccctagcatt acttatatga tatgtctcca tacccattac aatctccagc attccccctc 4261 aaacctaaga aatatgtctg ataaaagagt tactttgata gagtaaataa taggagctta 4321 aaccccctta tttctaggac tatgagaatc gaacccatcc ctgagaatcc aaaattctcc 4381 gtgccaccta tcacacccca tcctaaagta aggtcagcta aataagctat cgggcccata 4441 ccccgaaaat gttggttata cccttcccgt actaattaat cccctggccc aacccgtcat 4501 ctactctacc atctttgcag gcacactcat cactgcgcta agctcgcact gattttttac 4561 ctgagtaggc ctagaaataa acatgctagc ttttattcca gttctaacca aaaaaataaa 4621 ccctcgttcc acagaagctg ccatcaagta tttcctcacg caagcaaccg catccataat 4681 ccttctaata gctatcctct tcaacaatat actctccgga caatgaacca taaccaatac 4741 taccaatcaa tactcatcat taataatcat aatggctata gcaataaaac taggaatagc 4801 cccctttcac ttctgagtcc cagaggttac ccaaggcacc cctctgacat ccggcctgct 4861 tcttctcaca tgacaaaaac tagcccccat ctcaatcata taccaaatct ctccctcact 4921 aaacgtaagc cttctcctca ctctctcaat cttatccatc atagcaggca gttgaggtgg 4981 attaaaccaa acccagctac gcaaaatctt agcatactcc tcaattaccc acataggatg 5041 aataatagca gttctaccgt acaaccctaa cataaccatt cttaatttaa ctatttatat 5101 tatcctaact actaccgcat tcctactact caacttaaac tccagcacca cgaccctact 5161 actatctcgc acctgaaaca agctaacatg actaacaccc ttaattccat ccaccctcct 5221 ctccctagga ggcctgcccc cgctaaccgg ctttttgccc aaatgggcca ttatcgaaga 5281 attcacaaaa aacaatagcc tcatcatccc caccatcata gccaccatca ccctccttaa 5341 cctctacttc tacctacgcc taatctactc cacctcaatc acactactcc ccatatctaa 5401 caacgtaaaa ataaaatgac agtttgaaca tacaaaaccc accccattcc tccccacact 5461 catcgccctt accacgctac tcctacctat ctcccctttt atactaataa tcttatagaa 5521 atttaggtta aatacagacc aagagccttc aaagccctca gtaagttgca atacttaatt 5581 tctgtaacag ctaaggactg caaaacccca ctctgcatca actgaacgca aatcagccac 5641 tttaattaag ctaagccctt actagaccaa tgggacttaa acccacaaac acttagttaa 5701 cagctaagca ccctaatcaa ctggcttcaa tctacttctc ccgccgccgg gaaaaaaggc 5761 gggagaagcc ccggcaggtt tgaagctgct tcttcgaatt tgcaattcaa tatgaaaatc 5821 acctcggagc tggtaaaaag aggcctaacc cctgtcttta gatttacagt ccaatgcttc 5881 actcagccat tttacctcac ccccactgat gttcgccgac cgttgactat tctctacaaa 5941 ccacaaagac attggaacac tatacctatt attcggcgca tgagctggag tcctaggcac 6001 agctctaagc ctccttattc gagccgagct gggccagcca ggcaaccttc taggtaacga 6061 ccacatctac aacgttatcg tcacagccca tgcatttgta ataatcttct tcatagtaat 6121 acccatcata atcggaggct ttggcaactg actagttccc ctaataatcg gtgcccccga 6181 tatggcgttt ccccgcataa acaacataag cttctgactc ttacctccct ccctcctact 6241 cctgctcgca tctgctatag tggaggccgg agcaggaaca ggttgaacag tctaccctcc 6301 cttagcaggg aactactccc accctggagc ctccgtagac ctaaccatct tctccttaca 6361 cctagcaggt gtctcctcta tcttaggggc catcaatttc atcacaacaa ttatcaatat 6421 aaaaccccct gccataaccc aataccaaac gcccctcttc gtctgatccg tcctaatcac 6481 agcagtccta cttctcctat ctctcccagt cctagctgct ggcatcacta tactactaac 6541 agaccgcaac ctcaacacca ccttcttcga ccccgccgga ggaggagacc ccattctata 6601 ccaacaccta ttctgatttt tcggtcaccc tgaagtttat attcttatcc taccaggctt 6661 cggaataatc tcccatattg taacttacta ctccggaaaa aaagaaccat ttggatacat 6721 aggtatggtc tgagctataa tatcaattgg cttcctaggg tttatcgtgt gagcacacca 6781 tatatttaca gtaggaatag acgtagacac acgagcatat ttcacctccg ctaccataat 6841 catcgctatc cccaccggcg tcaaagtatt tagctgactc gccacactcc acggaagcaa 6901 tatgaaatga tctgctgcag tgctctgagc cctaggattc atctttcttt tcaccgtagg 6961 tggcctgact ggcattgtat tagcaaactc atcactagac atcgtactac acgacacgta 7021 ctacgttgta gctcacttcc actatgtcct atcaatagga gctgtatttg ccatcatagg 7081 aggcttcatt cactgatttc ccctattctc aggctacacc ctagaccaaa cctacgccaa 7141 aatccatttc actatcatat tcatcggcgt aaatctaact ttcttcccac aacactttct 7201 cggcctatcc ggaatgcccc gacgttactc ggactacccc gatgcataca ccacatgaaa 7261 catcctatca tctgtaggct cattcatttc tctaacagca gtaatattaa taattttcat 7321 gatttgagaa gccttcgctt cgaagcgaaa agtcctaata gtagaagaac cctccataaa 7381 cctggagtga ctatatggat gccccccacc ctaccacaca ttcgaagaac ccgtatacat 7441 aaaatctaga caaaaaagga aggaatcgaa cccccccaaa gctggtttca agccaacccc 7501 atggcctcca tgactttttc aaaaaggtat tagaaaaacc atttcataac tttgtcaaag 7561 ttaaattata ggctaaatcc tatatatctt aatggcacat gcagcgcaag taggtctaca 7621 agacgctact tcccctatca tagaagagct tatcaccttt catgatcacg ccctcataat 7681 cattttcctt atctgcttcc tagtcctgta tgcccttttc ctaacactca caacaaaact 7741 aactaatact aacatctcag acgctcagga aatagaaacc gtctgaacta tcctgcccgc 7801 catcatccta gtcctcatcg ccctcccatc cctacgcatc ctttacataa cagacgaggt 7861 caacgatccc tcccttacca tcaaatcaat tggccaccaa tggtactgaa cctacgagta 7921 caccgactac ggcggactaa tcttcaactc ctacatactt cccccattat tcctagaacc 7981 aggcgacctg cgactccttg acgttgacaa tcgagtagta ctcccgattg aagcccccat 8041 tcgtataata attacatcac aagacgtctt gcactcatga gctgtcccca cattaggctt 8101 aaaaacagat gcaattcccg gacgtctaaa ccaaaccact ttcaccgcta cacgaccggg 8161 ggtatactac ggtcaatgct ctgaaatctg tggagcaaac cacagtttca tgcccatcgt 8221 cctagaatta attcccctaa aaatctttga aataggaccc gtatttaccc tatagcaccc 8281 cctctacccc ctctagagcc cactgtaaag ctaacttagc attaaccttt taagttaaag 8341 attaagagaa ccaacacctc tttacagtga aatgccccaa ctaaatacta ccgtatggcc 8401 caccataatt acccccatac tccttacact attcctcatc acccaactaa aaatattaaa 8461 cacaaactac cacctacctc cctcaccaaa gcccataaaa ataaaaaatt ataacaaacc 8521 ctgagaacca aaatgaacga aaatctgttc gcttcattca ttgcccccac aatcctaggc 8581 ctacccgccg cagtactgat cattctattt ccccctctat tgatccccac ctccaaatat 8641 ctcatcaaca accgactaat caccacccaa caatgactaa tcaaactaac ctcaaaacaa 8701 atgataacca tacacaacac taaaggacga acctgatctc ttatactagt atccttaatc 8761 atttttattg ccacaactaa cctcctcgga ctcctgcctc actcatttac accaaccacc 8821 caactatcta taaacctagc catggccatc cccttatgag cgggcgcagt gattataggc 8881 tttcgctcta agattaaaaa tgccctagcc cacttcttac cacaaggcac acctacaccc 8941 cttatcccca tactagttat tatcgaaacc atcagcctac tcattcaacc aatagccctg 9001 gccgtacgcc taaccgctaa cattactgca ggccacctac tcatgcacct aattggaagc 9061 gccaccctag caatatcaac cattaacctt ccctctacac ttatcatctt cacaattcta 9121 attctactga ctatcctaga aatcgctgtc gccttaatcc aagcctacgt tttcacactt 9181 ctagtaagcc tctacctgca cgacaacaca taatgaccca ccaatcacat gcctatcata 9241 tagtaaaacc cagcccatga cccctaacag gggccctctc agccctccta atgacctccg 9301 gcctagccat gtgatttcac ttccactcca taacgctcct catactaggc ctactaacca 9361 acacactaac catataccaa tgatggcgcg atgtaacacg agaaagcaca taccaaggcc 9421 accacacacc acctgtccaa aaaggccttc gatacgggat agtcctattt attacctcag 9481 aagttttttt cttcgcagga tttttctgag ccttttacca ctccagccta gcccctaccc 9541 cccaattagg agggcactgg cccccaacag gcatcacccc gctaaatccc ctagaagtcc 9601 cactcctaaa cacatccgta ttactcgcat caggagtatc aatcacctga gctcaccata 9661 gtctaataga aaacaaccga aaccaaataa ttcaagcact gcttattaca attttactgg 9721 gtctctattt taccctccta caagcctcag agtacttcga gtctcccttc accatttccg 9781 acggcatcta cggctcaaca ttttttgtag ccacaggctt ccacggactt cacgtcatta 9841 ttggctcaac tttcctcact atctgcttca tccgccaact aatatttcac tttacatcca 9901 aacatcactt tggcttcgaa gccgccgcct gatactggca ttttgtagat gtggtttgac 9961 tatttctgta tatctccatc tattgatgag ggtcttactc ttttagtata aatagtaccg 10021 ttaacttcca attaactagc tttgacaaca ttcaaaaaag agtaataaac ttcgccttaa 10081 ttttaataat caacaccctc ctagccttac tactaataat tattacattt tgactaccac 10141 aactcaacgg ctacatagaa aaatccaccc cttacgagtg cggcttcgac cctatatccc 10201 ccgcccgcgt ccctttctcc ataaaattct tcttagtagc tatcaccttc ttattatttg 10261 atctagaaat tgccctcctt ttacccctac catgagccct acaaacaact aacctgccac 10321 taatagttat gtcatccctc ttattaatca tcatcctagc cctaagtctg gcctatgagt 10381 gactacaaaa aggattagac tgagccgaat tggtatatag tttaaacaaa acgaatgatt 10441 tcgactcatt aaattatgat aatcatattt accaaatgcc cctcatttac ataaatatta 10501 tactagcatt taccatctca cttctaggaa tactagtata tcgctcacac ctcatatcct 10561 ccctactatg cctagaagga ataatactat cgctgttcat tatagctact ctcataaccc 10621 tcaacaccca ctccctctta gccaatattg tgcctattgc catactagtc tttgccgcct 10681 gcgaagcagc ggtgggccta gccctactag tctcaatctc caacacatat ggcctagact 10741 acgtacataa cctaaaccta ctccaatgct aaaactaatc gtcccaacaa ttatattact 10801 accactgaca tgactttcca aaaaacacat aatttgaatc aacacaacca cccacagcct 10861 aattattagc atcatccctc tactattttt taaccaaatc aacaacaacc tatttagctg 10921 ttccccaacc ttttcctccg accccctaac aacccccctc ctaatactaa ctacctgact 10981 cctacccctc acaatcatgg caagccaacg ccacttatcc agtgaaccac tatcacgaaa 11041 aaaactctac ctctctatac taatctccct acaaatctcc ttaattataa cattcacagc 11101 cacagaacta atcatatttt atatcttctt cgaaaccaca cttatcccca ccttggctat 11161 catcacccga tgaggcaacc agccagaacg cctgaacgca ggcacatact tcctattcta 11221 caccctagta ggctcccttc ccctactcat cgcactaatt tacactcaca acaccctagg 11281 ctcactaaac attctactac tcactctcac tgcccaagaa ctatcaaact cctgagccaa 11341 caacttaata tgactagctt acacaatagc ttttatagta aagatacctc tttacggact 11401 ccacttatga ctccctaaag cccatgtcga agcccccatc gctgggtcaa tagtacttgc 11461 cgcagtactc ttaaaactag gcggctatgg tataatacgc ctcacactca ttctcaaccc 11521 cctgacaaaa cacatagcct accccttcct tgtactatcc ctatgaggca taattataac 11581 aagctccatc tgcctacgac aaacagacct aaaatcgctc attgcatact cttcaatcag 11641 ccacatagcc ctcgtagtaa cagccattct catccaaacc ccctgaagct tcaccggcgc 11701 agtcattctc ataatcgccc acggacttac atcctcatta ctattctgcc tagcaaactc 11761 aaactacgaa cgcactcaca gtcgcatcat aatcctctct caaggacttc aaactctact 11821 cccactaata gctttttgat gacttctagc aagcctcgct aacctcgcct taccccccac 11881 tattaaccta ctgggagaac tctctgtgct agtaaccacg ttctcctgat caaatatcac 11941 tctcctactt acaggactca acatactagt cacagcccta tactccctct acatatttac 12001 cacaacacaa tggggctcac tcacccacca cattaacaac ataaaaccct cattcacacg 12061 agaaaacacc ctcatgttca tacacctatc ccccattctc ctcctatccc tcaaccccga 12121 catcattacc gggttttcct cttgtaaata tagtttaacc aaaacatcag attgtgaatc 12181 tgacaacaga ggcttacgac cccttattta ccgagaaagc tcacaagaac tgctaactca 12241 tgcccccatg tctaacaaca tggctttctc aacttttaaa ggataacagc tatccattgg 12301 tcttaggccc caaaaatttt ggtgcaactc caaataaaag taataaccat gcacactact 12361 ataaccaccc taaccctgac ttccctaatt ccccccatcc ttaccaccct cgttaaccct 12421 aacaaaaaaa actcataccc ccattatgta aaatccattg tcgcatccac ctttattatc 12481 agtctcttcc ccacaacaat attcatatgc ctagaccaag aagttattat ctcgaactga 12541 cactgagcca caacccaaac aacccagctc tccctaagct tcaaactaga ctacttctcc 12601 ataatattca tccctgtagc attgttcgtt acatggtcca tcatagaatt ctcactgtga 12661 tatataaact cagacccaaa cattaatcag ttcttcaaat atctactcat tttcctaatt 12721 accatactaa tcttagttac cgctaacaac ctattccaac tgttcatcgg ctgagagggc 12781 gtaggaatta tatccttctt gctcatcagt tgatgatacg cccgagcaga tgccaacaca 12841 gcagccattc aagcaatcct atacaaccgt atcggcgata tcggtttcat cctcgcctta 12901 gcatgattta tcctacactc caactcatga gacccacaac aaatagccct tctaaacgct 12961 aatccaagcc tcaccccact actaggcctc ctcctagcag cagcaggcaa atcagcccaa 13021 ttaggtctcc acccctgact cccctcagcc atagaaggcc ccaccccagt ctcagcccta 13081 ctccactcaa gcactatagt tgtagcagga atcttcttac tcatccgctt ccacccccta 13141 gcagaaaata gcccactaat ccaaactcta acactatgct taggcgctat caccactctg 13201 ttcgcagcag tctgcgccct tacacaaaat gacatcaaaa aaatcgtagc cttctccact 13261 tcaagtcaac taggactcat aatagttaca atcggcatca accaaccaca cctagcattc 13321 ctgcacatct gtacccacgc cttcttcaaa gccatactat ttatgtgctc cgggtccatc 13381 atccacaacc ttaacaatga acaagatatt cgaaaaatag gaggactact caaaaccata 13441 cctctcactt caacctccct caccattggc agcctagcat tagcaggaat acctttcctc 13501 acaggtttct actccaaaga ccacatcatc gaaaccgcaa acatatcata cacaaacgcc 13561 tgagccctat ctattactct catcgctacc tccctgacaa gcgcctatag cactcgaata 13621 attcttctca ccctaacagg tcaacctcgc ttccccaccc ttactaacat taacgaaaat 13681 aaccccaccc tactaaaccc cattaaacgc ctggcagccg gaagcctatt cgcaggattt 13741 ctcattacta acaacatttc ccccgcatcc cccttccaaa caacagtccc cctctaccta 13801 aaactcacag ccctcgctgt cactttccta ggacttctaa cagccctaga cctcaactac 13861 ctaaccaaca aacttaaaat aaaatcccca ctatgcacat tttatttctc caacatactc 13921 ggattctacc ctagcatcac a