LOCUS AY195756 16573 bp DNA circular PRI 10-JUN-2004 DEFINITION Homo sapiens haplotype E23N1B mitochondrion, complete genome. ACCESSION AY195756 VERSION AY195756.2 GI:48596154 KEYWORDS . SOURCE mitochondrion Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 16573) AUTHORS Mishmar,D., Ruiz-Pesini,E., Golik,P., Macaulay,V., Clark,A.G., Hosseini,S., Brandon,M., Easley,K., Chen,E., Brown,M.D., Sukernik,R.I., Olckers,A. and Wallace,D.C. TITLE Natural selection shaped regional mtDNA variation in humans JOURNAL Proc. Natl. Acad. Sci. U.S.A. 100 (1), 171-176 (2003) MEDLINE 22406325 PUBMED 12509511 REFERENCE 2 (bases 1 to 16573) AUTHORS Mishmar,D., Ruiz-Pesini,E., Golik,P., Macaulay,V., Clark,A.G., Hosseini,S., Brandon,M., Easley,K., Chen,E., Brown,M.D., Sukernik,R.I., Olckers,A. and Wallace,D.C. TITLE Direct Submission JOURNAL Submitted (11-DEC-2002) MAMMAG, University of California, Irvine, 2nd Floor Hewitt Hall, Irvine, California 92697-3940, USA REFERENCE 3 (bases 1 to 16573) AUTHORS Mishmar,D., Ruiz-Pesini,E., Golik,P., Macaulay,V., Clark,A.G., Hosseini,S., Brandon,M., Easley,K., Chen,E., Brown,M.D., Sukernik,R.I., Olckers,A. and Wallace,D.C. TITLE Direct Submission JOURNAL Submitted (10-JUN-2004) MAMMAG, University of California, Irvine, 2nd Floor Hewitt Hall, Irvine, California 92697-3940, USA REMARK Sequence update by submitter COMMENT On Jun 10, 2004 this sequence version replaced gi:29690546. FEATURES Location/Qualifiers source 1..16573 /organism="Homo sapiens" /organelle="mitochondrion" /mol_type="genomic DNA" /isolation_source="N1B haplogroup" /db_xref="taxon:9606" /haplotype="E23N1B" D-loop complement(join(16108..16573,1..191)) tRNA 578..648 /product="tRNA-Phe" rRNA 649..1606 /product="12S ribosomal RNA" tRNA 1607..1675 /product="tRNA-Val" rRNA 1676..3233 /product="16S ribosomal RNA" tRNA 3234..3308 /product="tRNA-Leu" gene 3311..4267 /gene="ND1" CDS 3311..4267 /gene="ND1" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 1" /protein_id="AAO88423.1" /db_xref="GI:29690547" /translation="MPMANLLLLIVPILIAMAFLMLTERKILGYMQLRKGPNVVGPYG LLQPFADAMKLFTKEPLKPATSTITLYITAPTLALTIALLLWTPLPMPNPLVNLNLGL LFILATSSLAVYSILWSGWASNSNYALIGALRAVAQTISYEVTLAIILLSTLLMSGSF NLSTLITTQEHLWLLLPSWPLAMMWFISTLAETNRTPFDLAEGESELVSGFNIEYAAG PFALFFMAEYTNIIMMNTLTTTIFLGTTYDALSPELYTTYFVTKTLLLTSLFLWIRTA YPRFRYDQLMHLLWKNFLPLTLALLMWYVSMPITISSIPPQT" tRNA 4267..4335 /product="tRNA-Ile" tRNA complement(4333..4404) /product="tRNA-Gln" tRNA 4406..4473 /product="tRNA-Met" gene 4474..5517 /gene="ND2" CDS 4474..5517 /gene="ND2" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 2" /protein_id="AAO88424.1" /db_xref="GI:29690548" /translation="MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVL TKKMNPRSTEAAIKYFLTQATASMILLMAILFNNMLSGQWTMTNTTNQYSSLMIMMAM AMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPSLNVSLLLTLSIL SIMVGSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLL LNLNSSTTTLLLSRTWNKLTWLTPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSL IIPTIMATITLLNLYFYLRLIYSTSITLLPMSNNVKMKWQFEHTKPTPFLPTLIALTT LLLPISPFMLMIL" tRNA 5516..5583 /product="tRNA-Trp" tRNA complement(5591..5659) /product="tRNA-Ala" tRNA complement(5661..5733) /product="tRNA-Asn" tRNA complement(5765..5830) /product="tRNA-Cys" tRNA complement(5830..5895) /product="tRNA-Tyr" gene 5908..7449 /gene="COX1" CDS 5908..7449 /gene="COX1" /codon_start=1 /transl_table=2 /product="cytochrome oxidase subunit I" /protein_id="AAO88425.1" /db_xref="GI:29690549" /translation="MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQP GNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSF WLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILG AINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTT FFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWA MMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKW SAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGG FIHWFPLFSGYTLDQTYAKIHFTIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTW NILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEEP VYMKS" tRNA complement(7449..7520) /product="tRNA-Ser" tRNA 7522..7589 /product="tRNA-Asp" gene 7590..8273 /gene="COX2" CDS 7590..8273 /gene="COX2" /codon_start=1 /transl_table=2 /product="cytochrome oxidase subunit II" /protein_id="AAO88426.1" /db_xref="GI:29690550" /translation="MAHAAQVGLQDATSPIMEELITFHDHALMIIFLICFLVLYALFL TLTTKLTNTNISDAQEMETVWTILPAIILVLIALPSLRILYMTDEVNDPSLTIKSIGH QWYWTYEYTDYGGLIFNSYMLPPLFLEPGDLRLLDVDNRVVLPIEAPIRMMITSQDVL HSWAVPTLGLKTDAIPGRLNQTTFTATRPGVYYGQCSEICGANHSFMPIVLELIPLKI FEMGPVFTL" tRNA 8299..8368 /product="tRNA-Lys" gene 8370..8576 /gene="ATP8" CDS 8370..8576 /gene="ATP8" /codon_start=1 /transl_table=2 /product="ATP synthase F0 subunit 8" /protein_id="AAO88427.1" /db_xref="GI:29690551" /translation="MPQLNTTVWPTMITPMLLTLFLITQLKMLNTNYHLLPSPKPMKM KNYNKPWEPKWTKICSLHSLPPQS" gene 8531..9211 /gene="ATP6" CDS 8531..9211 /gene="ATP6" /codon_start=1 /transl_table=2 /product="ATP synthase F0 subunit 6" /protein_id="AAO88428.1" /db_xref="GI:29690552" /translation="MNENLFASFIAPTILGLPAAVLIILFPPLLIPTSKYLINNRLIT TQQWLIKLTSKQMMTMHNTKGRTWSLMLVSLIIFIATTNLLGLLPHSFTPTTQLSMNL AVAIPLWAGAVIMGFRSKIKNALAHFLPQGTPTPLIPMLVIIEAISLLIQPMALAVRL TANITAGHLLMHLIGSATLAMSTINLPSTLIIFTILILLTILEIAVALIQAYVFTLLV SLYLHDNT" gene 9211..9991 /gene="COX3" CDS 9211..9991 /gene="COX3" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:9991,aa:TERM) /transl_table=2 /product="cytochrome oxidase subunit III" /protein_id="AAO88429.1" /db_xref="GI:29690553" /translation="MTHQSHAYHMVKPSPWPLTGALSALLMTSGLAMWFHFHSMTLLM LGLLTNTLTMYQWWRDVTRESTYQGHHTPPVQKGLRYGMILFITSEVFFFAGFFWAFY HSSLAPTPQLGGHWPPTGITPLNPLEVPLLNTSVLLASGVSITWAHHSLMENNRNQMI QALLITILLGLYFTLLQASEYFESPFTISDGIYGSTFFVATGFHGLHVIIGSTFLTIC FIRQLMFHFTSKHHFGFEAAAWYWHFVDVVWLLLYVSIYWWG" tRNA 9995..10062 /product="tRNA-Gly" gene 10063..10408 /gene="ND3" CDS 10063..10408 /gene="ND3" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:10408,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 3" /protein_id="AAO88430.1" /db_xref="GI:29690554" /translation="MNFALILMINTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPM SPARVPFSMKFFLVAITFLLFDLEIALLLPLPWALQTTNLPLMVMSSLLLIIILALSL AYEWLQKGLDWTE" tRNA 10409..10473 /product="tRNA-Arg" gene 10474..10770 /gene="ND4L" CDS 10474..10770 /gene="ND4L" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 4L" /protein_id="AAO88431.1" /db_xref="GI:29690555" /translation="MPLIYMNIMLAFTISLLGMLVYRSHLMSSLLCLEGMMLSLFIMA TLMTLNTHSLLANIVPIAMLVFAACEAAVGLALLVSISNTYGLDYVHNLNLLQC" gene 10764..12141 /gene="ND4" CDS 10764..12141 /gene="ND4" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:12141,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 4" /protein_id="AAO88432.1" /db_xref="GI:29690556" /translation="MLKLIVPTIMLLPLTWLSKKHMIWINTTTHSLIISIIPLLFFNQ INNNLFSCSPTFSSDPLTTPLLMLTTWLLPLTIMASQRHLSSEPLSRKKLYLSMLISL QISLIMTFTATELIMFYIFFETTLIPTLAIITRWGNQPERLNAGTYFLFYTLVGSLPL LIALIYTHNTLGSLNILLLTLTAQELSNSWANNLMWLAYTMAFMVKMPLYGLHLWLPK AHVEAPIAGSMVLAAVLLKLGGYGMMRLTLILNPLTKHMAYPFLVLSLWGMIMTSSIC LRQTDLKSLIAYSSISHMALVVTAILIQTPWSFTGAVILMIAHGLTSSLLFCLANSNY ERTHSRIMILSQGLQTLLPLMAFWWLLASLANLALPPTINLLGELSVLVTTFSWSNIT LLLTGLNMLVTALYSLYMFTTTQWGSLTHHINNMKPSFTRENTLMFMHLSPILLLSLN PDIITGFSS" tRNA 12142..12210 /product="tRNA-His" tRNA 12211..12269 /product="tRNA-Ser" tRNA 12270..12340 /product="tRNA-Leu" gene 12341..14152 /gene="ND5" CDS 12341..14152 /gene="ND5" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 5" /protein_id="AAO88433.1" /db_xref="GI:29690557" /translation="MTMHTTMTTLTLTSLIPPILTTLVNPNKKNSYPHYVKSIVASTF IISLFPTTMFMCLDQEVIISNWHWATTQTTQLSLSFKLDYFSMMFIPVALFVTWSIME FSLWYMNSDPNINQFFKYLLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLISWWYA RADANTAAIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLNANPSLTPLLGLLL AAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFHPLAENSPLIQTL TLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAF FKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSK DHIIETANMSYTNAWALSITLIATSLTSAYSTRMILLTLTGQPRFPTLTNINENNPTL LNPIKRLAAGSLFAGFLITNNISPASPFQTTIPLYLKLTALAVTFLGLLTALDLNYLT NKLKMKSPLCTFYFSNMLGFYPSITHRTIPYLGLLTSQNLPLLLLDLTWLEKLLPKTI SQHQISTSIITSTQKGMIKLYFLSFFFPLILTLLLIT" gene complement(14153..14677) /gene="ND6" CDS complement(14153..14677) /gene="ND6" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 6" /protein_id="AAO88434.1" /db_xref="GI:29690558" /translation="MMYALFLLSVGLVMGFVGFSSKPSPIYGGLVLIVSGVVGCVIIL NFGGGYMGLMVFLIYLGGMMVVFGYTTAMAIEEYPEAWGSGVEVLVSVLVGLAMEVGL VLWVKEYDGVVVVVNFNSVGSWMIYEGEGSGLIREDPIGAGALYDYGRWLVVVTGWTL FVGVYIVIEIARGN" tRNA complement(14678..14746) /product="tRNA-Glu" gene 14751..15885 /gene="cytb" CDS 14751..15885 /gene="cytb" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:15885,aa:TERM) /transl_table=2 /product="cytochrome b" /protein_id="AAO88435.1" /db_xref="GI:29690559" /translation="MTPMRKINPLMKLINHSFIDLPTPSNISAWWNFGSLLGACLILQ ITTGLFLAMHYSPDASTAFSSIAHITRDVNYGWIIRYLHANGASMFFICLFLHIGRGL YYGSFLYSETWNIGIILLLATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDL VQWIWGGYSVDSPTLTRFFTFHFILPFIIAALAALHLLFLHETGSNNPLGITSHSDKI TFHPYYTIKDALGLLLFLLSLMTLTLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLF AYTILRSVPNKLGGVLALLLSILILAMIPILHMSKQQSMMFRPLSQSLYWLLAADLLI LTWIGGQPVSYPFTIIGQVASVLYFTTILILMPTISLIENKMLK" tRNA 15892..15957 /product="tRNA-Thr" tRNA complement(15959..16027) /product="tRNA-Pro" ORIGIN 1 gatcacaggt ctatcaccct attaaccact cacgggagct ctccatgcat ttggtatttt 61 cgtctggggg gtgtgcacgc gatagcattg cgagacgctg gagccggagc accctatgtc 121 gcagtatctg tctttgattc ctgccccatt ccattattta tcgcacctac gttcaatatt 181 acaggcgaac atacttacta aagtgtgtta attaattaat gcttgtagga cataataata 241 acaattgaat gtctgcacag ccgctttcca cacagacatc ataacaaaaa atttccacca 301 aacccccccc ctccccccgc ttttggccac agcacttaaa cacatctctg ccaaacccca 361 aaaacaaaga accctaacac cagcctaacc agatttcaaa ttttatcttt tggcggtatg 421 cacttttaac agtcaccccc caactaacac attattttcc cctcccactc ccatactact 481 aatctcatca atacaacccc cgcccatcct acccagcaca cacaccgctg ctaaccccat 541 accccgaacc aaccaaaccc caaagacacc ccccacagtt tatgtagctt acctcctcaa 601 agcaatacac tgaaaatgtt tagacgggct cacatcaccc cataaacaaa taggtttggt 661 cctagccttt ctattagctc ttagtaagat tacacatgca agcatccccg ttccagtgag 721 ttcaccctct aaatcaccac gatcaaaagg gacaagcatc aagcacgcag caatgcagct 781 caaaacgctt agcctagcca cacccccacg ggaaacagca gtgattaacc tttagcaata 841 aacgaaagtt taactaagct atactaaccc cagggttggt caatttcgtg ccagccaccg 901 cggtcacacg attaacccaa gtcaatagaa gccggcgtaa agagtgtttt agatcacccc 961 cccccccccc aataaagcta aaactcacct gagttgtaaa aaactccagt tgacacaaaa 1021 tagactacga aagtggcttt aacatatctg aacacacaat agctaagacc caaactggga 1081 ttagataccc cactatgctt agccctaaac ctcaacagtt aaatcaacaa aactgctcgc 1141 cagaacacta cgagccacag cttaaaactc aaaggacctg gcggtgcttc atatccctct 1201 agaggagcct gttctgtaat cgataaaccc cgatcaacct caccacctct tgctcagcct 1261 atataccgcc atcttcagca aaccctgatg aaggctacaa agtaagcgca agtacccacg 1321 taaagacgtt aggtcaaggt gtagcccatg aggtggcaag aaatgggcta cattttctac 1381 cccagaaaac tacgatagcc cttatgaaac ttaagggtcg aaggtggatt tagcagtaaa 1441 ctgagagtag agtgcttagt tgaacagggc cctgaagcgc gtacacaccg cccgtcaccc 1501 tcctcaagta tacttcaaag gacatttaac taaaacccct acgcatttat atagaggaga 1561 caagtcgtaa catggtaagt gtactggaaa gtgcacttgg acaaaccaga gtgtagctta 1621 acacaaagca cccaacttac acttaggaga tttcaactta acttgaccgc tctgagctaa 1681 acctagcccc aaacccactc caccttatta ccagacaacc ttaaccaaac catttaccca 1741 aataaagtat aggcgataga aattgaaacc tggcgcaata gatatagtac cgcaagggaa 1801 agatgaaaaa ttataaccaa gcataatata gcaaggacta acccctatac cttctgcata 1861 atgaattaac tagaaataac tttgcaagga gagccaaagc taagaccccc gaaaccagac 1921 gagctaccta agaacagcta aaagagcaca cccgtctatg tagcaaaata gtgggaagat 1981 ttataggtag aggcgacaaa cctaccgagc ctggtgatag ctggttgtcc aagatagaat 2041 cttagttcaa ctttaaattt gcccacagaa ccctctaaat ccccttgtaa atttaactgt 2101 tagtccaaag aggaacagct ctttggacac taggaaaaaa ccttgtagag agagtaaaaa 2161 atttaacacc catagtaggc ctaaaagcag ccaccaatta agaaagcgtt caagctcaac 2221 acccactacc taaaaaatcc caaacatata actgaactcc tcacacccaa ttggaccaat 2281 ctatcaccct atagaagaac taatgttagt ataagtaaca tgaaaacatt ctcctccgca 2341 taagcctgcg tcagattaaa acactgaact gacaattaac agcccaatat ctacaatcaa 2401 ccaacaagtc attattaccc tcactgtcaa cccaacacag gcatgctcat aaggaaaggt 2461 taaaaaaagt aaaaggaact cggcaaatct taccccgcct gtttaccaaa aacatcacct 2521 ctagcatcac cagtattaga ggcaccgcct gcccagtgac acatgtttaa cggccgcggt 2581 accctaaccg tgcaaaggta gcataatcac ttgttcctta aatagggacc tgtatgaatg 2641 gcttcacgag ggttcagctg tctcttactt ttaaccagtg aaattgacct gcccgtgaag 2701 aggcgggcat gacacagcaa gacgagaaga ccctatggag ctttaattta ttaatgcaaa 2761 cagtacctaa caaacccaca ggtcctaaac taccaaacct gcattaaaaa tttcggttgg 2821 ggcgacctcg gagcagaacc caacctccga gcagtacatg ctaagacttc accagtcaaa 2881 gcgaactact atactcaatt gatccaataa cttgaccaac ggaacaagtt accctaggga 2941 taacagcgca atcctattct agagtccata tcaacaatag ggtttacgac ctcgatgttg 3001 gatcaggaca tcccgatggt gcagccgcta ttaaaggttc gtttgttcaa cgattaaagt 3061 cctacgtgat ctgagttcag accggagcaa tccaggtcgg tttctatcta cttcaaattc 3121 ctccctgtac gaaaggacaa gagaaataag gcctacttca caaagcgcct tcccccgtaa 3181 atgatatcat ctcaacttag tattataccc acacccaccc aagaacaggg tttgttaaga 3241 tggcagagcc cggtaatcgc ataaaactta aaactttaca gtcagaggtt caattcctct 3301 tcttaacaac atacccatgg ccaacctcct actcctcatt gtacccattc taatcgcaat 3361 ggcattccta atgcttaccg aacgaaaaat tctaggctat atacaactac gcaaaggccc 3421 caacgttgta ggcccctacg ggctactaca acccttcgct gacgccataa aactcttcac 3481 caaagagccc ctaaaacccg ccacatctac catcaccctc tacatcaccg ccccgacctt 3541 agctctcacc atcgctcttc tactatgaac ccccctcccc atacccaacc ccctggtcaa 3601 cctcaaccta ggcctcctat ttattctagc cacctctagc ctagccgttt actcaatcct 3661 ctgatcaggg tgagcatcaa actcaaacta cgccctgatc ggcgcactgc gagcagtagc 3721 ccaaacaatc tcatatgaag tcaccctagc catcattcta ctatcaacat tactaataag 3781 tggctccttt aacctctcca cccttatcac aacacaagaa cacctctgat tactcctgcc 3841 atcatgaccc ttggccataa tatgatttat ctccacacta gcagagacca accgaacccc 3901 cttcgacctt gccgaagggg agtcagaact agtctcaggc ttcaacatcg aatacgccgc 3961 aggccccttc gccctattct tcatagccga atacacaaac attattataa taaacaccct 4021 caccactaca atcttcctag gaacaacata tgacgcactc tcccctgaac tctacacaac 4081 atattttgtc accaagaccc tacttctaac ctccctgttc ttatgaattc gaacagcata 4141 cccccgattc cgctacgacc aactcataca cctcctatga aaaaacttcc taccactcac 4201 cctagcatta cttatatgat atgtctccat acccattaca atctccagca ttccccctca 4261 aacctaagaa atatgtctga taaaagagtt actttgatag agtaaataat aggagcttaa 4321 acccccttat ttctaggact atgagaatcg aacccatccc tgagaatcca aaattctccg 4381 tgccacctat cacaccccat cctaaagtaa ggtcagctaa ataagctatc gggcccatac 4441 cccgaaaatg ttggttatac ccttcccgta ctaattaatc ccctggccca acccgtcatc 4501 tactctacca tctttgcagg cacactcatc acagcgctaa gctcgcactg attttttacc 4561 tgagtaggcc tagaaataaa catgctagct tttattccag ttctaaccaa aaaaataaac 4621 cctcgttcca cagaagctgc catcaagtat ttcctcacgc aagcaaccgc atccataatc 4681 cttctaatag ctatcctctt caacaatata ctctccggac aatgaaccat aaccaatact 4741 accaatcaat actcatcatt aataatcata atggctatag caataaaact aggaatagcc 4801 ccctttcact tctgagtccc agaggttacc caaggcaccc ctctgacatc cggcctgctt 4861 cttctcacat gacaaaaact agcccccatc tcaatcatat accaaatctc tccctcacta 4921 aacgtaagcc ttctcctcac tctctcaatc ttatccatca tagtaggcag ttgaggtgga 4981 ttaaaccaaa cccagctacg caaaatctta gcatactcct caattaccca cataggatga 5041 ataatagcag ttctaccgta caaccctaac ataaccattc ttaatttaac tatttatatt 5101 atcctaacta ctaccgcatt cctactactc aacttaaact ccagcaccac gaccctacta 5161 ctatctcgca cctgaaacaa gctaacatga ctaacaccct taattccatc caccctcctc 5221 tccctaggag gcctgccccc gctaaccggc tttttgccca aatgggccat tatcgaagaa 5281 ttcacaaaaa acaatagcct catcatcccc accatcatag ccaccatcac cctccttaac 5341 ctctacttct acctacgcct aatctactcc acctcaatca cactactccc catatctaac 5401 aacgtaaaaa taaaatgaca gtttgaacat acaaaaccca ccccattcct ccccacactc 5461 atcgccctta ccacactact cctacctatc tcccctttta tactaataat cttatagaaa 5521 tttaggttaa atacagacca agagccttca aagccctcag taagttgcaa tacttaattt 5581 ctgtaacagc taaggactgc aaaaccccac tctgcatcaa ctgaacgcaa atcagccact 5641 ttaattaagc taagccctta ctagaccaat gggacttaaa cccacaaaca cttagttaac 5701 agctaagcac cctaatcaac tggcttcaat ctacttctcc cgccgccggg aaaaaaggcg 5761 ggagaagccc cggcaggttt gaagctgctt cttcgaattt gcaattcaat atgaaaatca 5821 cctcggagct ggtaaaaaga ggcctaaccc ctgtctttag atttacagtc caatgcttca 5881 ctcagccatt ttacctcacc cccactgatg ttcgccgacc gttgactatt ctctacaaac 5941 cacaaagaca ttggaacact atacctatta ttcggcgcat gagctggagt cctaggcaca 6001 gctctaagcc tccttattcg agccgagctg ggccagccag gcaaccttct aggtaacgac 6061 cacatctaca acgttatcgt cacagcccat gcatttgtaa taatcttctt catagtaata 6121 cccatcataa tcggaggctt tggcaactga ctagttcccc taataatcgg tgcccccgat 6181 atggcgtttc cccgcataaa caacataagc ttctgactct tacctccctc tctcctactc 6241 ctgctcgcat ctgctatagt ggaggccgga gcaggaacag gttgaacagt ctaccctccc 6301 ttagcaggga actactccca ccctggagcc tccgtagacc taaccatctt ctccttacac 6361 ctagcaggtg tctcctctat cttaggggcc atcaatttca tcacaacaat tatcaatata 6421 aaaccccctg ccataaccca ataccaaacg cccctcttcg tctgatccgt cctaatcaca 6481 gcagtcctac ttctcctatc tctcccagtc ctagctgctg gcatcactat actactaaca 6541 gaccgcaacc tcaacaccac cttcttcgac cccgccggag gaggagaccc cattctatac 6601 caacacctat tctgattttt cggtcaccct gaagtttata ttcttatcct accaggcttc 6661 ggaataatct cccatattgt aacttactac tccggaaaaa aagaaccatt tggatacata 6721 ggtatggtct gagctatgat atcaattggc ttcctagggt ttatcgtgtg agcacaccat 6781 atatttacag taggaataga cgtagacaca cgagcatatt tcacctccgc taccataatc 6841 atcgctatcc ccaccggcgt caaagtattt agctgactcg ccacactcca cggaagcaat 6901 atgaaatgat ctgctgcagt gctctgagcc ctaggattca tctttctttt caccgtaggt 6961 ggcctgactg gcattgtatt agcaaactca tcactagaca tcgtactaca cgacacgtac 7021 tacgttgtag ctcacttcca ctatgtccta tcaataggag ctgtatttgc catcatagga 7081 ggcttcattc actgatttcc cctattctca ggctacaccc tagaccaaac ctacgccaaa 7141 atccatttca ctatcatatt catcggcgta aatctaactt tcttcccaca acactttctc 7201 ggcctatccg gaatgccccg acgttactcg gactaccccg atgcatacac cacatgaaac 7261 atcctatcat ctgtaggctc attcatttct ctaacagcag taatattaat aattttcatg 7321 atttgagaag ccttcgcttc gaagcgaaaa gtcctaatag tagaagaacc ctccataaac 7381 ctggagtgac tatatggatg ccccccaccc taccacacat tcgaagaacc cgtatacata 7441 aaatctagac aaaaaaggaa ggaatcgaac cccccaaagc tggtttcaag ccaaccccat 7501 ggcctccatg actttttcaa aaaggtatta gaaaaaccat ttcataactt tgtcaaagtt 7561 aaattatagg ctaaatccta tatatcttaa tggcacatgc agcgcaagta ggtctacaag 7621 acgctacttc ccctatcata gaagagctta tcacctttca tgatcacgcc ctcataatca 7681 ttttccttat ctgcttccta gtcctgtatg cccttttcct aacactcaca acaaaactaa 7741 ctaatactaa catctcagac gctcaggaaa tagaaaccgt ctgaactatc ctgcccgcca 7801 tcatcctagt cctcatcgcc ctcccatccc tacgcatcct ttacataaca gacgaggtca 7861 acgatccctc ccttaccatc aaatcaattg gccaccaatg gtactgaacc tacgagtaca 7921 ccgactacgg cggactaatc ttcaactcct acatacttcc cccattattc ctagaaccag 7981 gcgacctgcg actccttgac gttgacaatc gagtagtact cccgattgaa gcccccattc 8041 gtataataat tacatcacaa gacgtcttgc actcatgagc tgtccccaca ttaggcttaa 8101 aaacagatgc aattcccgga cgtctaaacc aaaccacttt caccgctaca cgaccggggg 8161 tatactacgg tcaatgctct gaaatctgtg gagcaaacca cagtttcatg cccatcgtcc 8221 tagaattaat tcccctaaaa atctttgaaa taggacccgt atttacccta tagcaccccc 8281 tctaccccct ctagagccca ctgtaaagct aacttagcat taacctttta agttaaagat 8341 taagagaacc aacacctctt tacagtgaaa tgccccaact aaatactacc gtatggccca 8401 ccataattac ccccatactc cttacactat tcctcatcac ccaactaaaa atattaaaca 8461 caaactacca cctacttccc tcaccaaagc ccataaaaat aaaaaattat aacaaaccct 8521 gagaaccaaa atgaacgaaa atctgttcgc ttcattcatt gcccccacaa tcctaggcct 8581 acccgccgca gtactgatca ttctatttcc ccctctattg atccccacct ccaaatatct 8641 catcaacaac cgactaatca ccacccaaca atgactaatc aaactaacct caaaacaaat 8701 gataaccata cacaacacta aaggacgaac ctgatctctt atactagtat ccttaatcat 8761 ttttattgcc acaactaacc tcctcggact cctgcctcac tcatttacac caaccaccca 8821 actatctata aacctagccg tggccatccc cttatgagcg ggcgcagtga ttataggctt 8881 tcgctctaag attaaaaatg ccctagccca cttcttacca caaggcacac ctacacccct 8941 tatccccata ctagttatta tcgaagccat cagcctactc attcaaccaa tagccctggc 9001 cgtacgccta accgctaaca ttactgcagg ccacctactc atgcacctaa ttggaagcgc 9061 caccctagca atatcaacca ttaaccttcc ctctaccctt atcatcttca caattctaat 9121 tctactgact atcctagaaa tcgctgtcgc cttaatccaa gcctacgttt tcacacttct 9181 agtaagcctc tacctgcacg acaacacata atgacccacc aatcacatgc ctatcatata 9241 gtaaaaccca gcccatgacc cctaacaggg gccctctcag ccctcctaat gacctccggc 9301 ctagccatgt gatttcactt ccactccata acgctcctta tactaggcct actaaccaac 9361 acactaacca tataccaatg atggcgcgat gtaacacgag aaagcacata ccaaggccac 9421 cacacaccac ctgtccaaaa aggccttcga tacgggataa tcctatttat tacctcagaa 9481 gtttttttct tcgcaggatt tttctgagcc ttttaccact ccagcctagc ccctaccccc 9541 caattaggag ggcactggcc cccaacaggc atcaccccgc taaatcccct agaagtccca 9601 ctcctaaaca catccgtatt actcgcatca ggagtatcaa tcacctgagc tcaccatagt 9661 ctaatagaaa acaaccgaaa ccaaataatt caagcactgc ttattacaat tttactgggt 9721 ctctatttta ccctcctaca agcctcagag tacttcgagt ctcccttcac catttccgac 9781 ggcatctacg gctcaacatt ttttgtagcc acaggcttcc acggacttca cgtcattatt 9841 ggctcaactt tcctcactat ctgcttcatc cgccaactaa tatttcactt tacatccaaa 9901 catcactttg gcttcgaagc cgccgcctga tactggcatt ttgtagatgt ggtttgacta 9961 cttctgtatg tctccatcta ttgatgaggg tcttactctt ttagtataaa tagtaccgtt 10021 aacttccaat taactagttt tgacaacatt caaaaaagag taataaactt cgccttaatt 10081 ttaataatca acaccctcct agccttacta ctaataatta ttacattttg actaccacaa 10141 ctcaacggct acatagaaaa atccacccct tacgagtgcg gcttcgaccc tatatccccc 10201 gcccgcgtcc ctttctccat aaaattcttc ttagtagcta tcaccttctt attatttgat 10261 ctagaaattg ccctcctttt acccctacca tgagccctac aaacaactaa cctgccacta 10321 atagttatgt catccctctt attaatcatc atcctagccc taagtctggc ctatgagtga 10381 ctacaaaaag gattagactg aaccgaattg gtatatagtt taaacaaaac gaatgatttc 10441 gactcattaa attatgataa tcatatttac caaatgcccc tcatttacat aaatattata 10501 ctagcattta ccatctcact tctaggaata ctagtatatc gctcacacct catatcctcc 10561 ctactatgcc tagaaggaat aatactatcg ctgttcatta tagctactct cataaccctc 10621 aacacccact ccctcttagc caatattgtg cctattgcca tactagtctt tgccgcctgc 10681 gaagcagcgg tgggcctagc cctactagtc tcaatctcca acacatatgg cctagactac 10741 gtacataacc taaacctact ccaatgctaa aactaatcgt cccaacaatt atattactac 10801 cactgacatg actttccaaa aaacacataa tttgaatcaa cacaaccacc cacagcctaa 10861 ttattagcat catccctcta ctatttttta accaaatcaa caacaaccta tttagctgtt 10921 ccccaacctt ttcctccgac cccctaacaa cccccctcct aatactaact acctgactcc 10981 tacccctcac aatcatggca agccaacgcc acttatccag tgaaccacta tcacgaaaaa 11041 aactctacct ctctatacta atctccctac aaatctcctt aattataaca ttcacagcca 11101 cagaactaat catattttat atcttcttcg aaaccacact tatccccacc ttggctatca 11161 tcacccgatg aggcaaccag ccagaacgcc tgaacgcagg cacatacttc ctattctaca 11221 ccctagtagg ctcccttccc ctactcatcg cactaattta cactcacaac accctaggct 11281 cactaaacat tctactactc actctcactg cccaagaact atcaaactcc tgagccaaca 11341 acttaatatg actagcttac acaatggctt ttatagtaaa gatacctctt tacggactcc 11401 acttatgact ccctaaagcc catgtcgaag cccccatcgc tgggtcaata gtacttgccg 11461 cagtactctt aaaactaggc ggctatggta taatacgcct cacactcatt ctcaaccccc 11521 tgacaaaaca catagcctac cccttccttg tactatccct atgaggcata attataacaa 11581 gctccatctg cctacgacaa acagacctaa aatcgctcat tgcatactct tcaatcagcc 11641 acatagccct cgtagtaaca gccattctca tccaaacccc ctgaagcttc accggcgcag 11701 tcattctcat aatcgcccac ggacttacat cctcattact attctgccta gcaaactcaa 11761 actacgaacg cactcacagt cgcatcataa tcctctctca aggacttcaa actctactcc 11821 cactaatagc tttttgatga cttctagcaa gcctcgctaa cctcgcctta ccccccacta 11881 ttaacctact gggagaactc tctgtgctag taaccacgtt ctcctgatca aatatcactc 11941 tcctacttac aggactcaac atactagtca cagccctata ctccctctac atatttacca 12001 caacacaatg gggctcactc acccaccaca ttaacaacat aaaaccctca ttcacacgag 12061 aaaacaccct catgttcata cacctatccc ccattctcct cctatccctc aaccccgaca 12121 tcattaccgg gttttcctct tgtaaatata gtttaaccaa aacatcagat tgtgaatctg 12181 acaacagagg cttacgaccc cttatttacc gagaaagctc acaagaactg ctaactcatg 12241 cccccatgtc taacaacatg gctttctcaa cttttaaagg ataacagcta tccattggtc 12301 ttaggcccca aaaattttgg tgcaactcca aataaaagta ataaccatgc acactactat 12361 aaccacccta accctgactt ccctaattcc ccccatcctt accaccctcg ttaaccctaa 12421 caaaaaaaac tcataccccc attatgtaaa atccattgtc gcatccacct ttattatcag 12481 tctcttcccc acaacaatat tcatatgcct agaccaagaa gttattatct cgaactgaca 12541 ctgagccaca acccaaacaa cccagctctc cctaagcttc aaactagact acttctccat 12601 aatattcatc cctgtagcat tgttcgttac atggtccatc atagaattct cactgtgata 12661 tataaactca gacccaaaca ttaatcagtt cttcaaatat ctactcattt tcctaattac 12721 catactaatc ttagttaccg ctaacaacct attccaactg ttcatcggct gagagggcgt 12781 aggaattata tccttcttgc tcatcagttg atgatacgcc cgagcggatg ccaacacagc 12841 agccattcaa gcaatcctat acaaccgtat cggcgatatc ggtttcatcc tcgccttagc 12901 atgatttatc ctacactcca actcatgaga cccacaacaa atagcccttc taaacgctaa 12961 tccaagcctc accccactac taggcctcct cctagcagca gcaggcaaat cagcccaatt 13021 aggtctccac ccctgactcc cctcagccat agaaggcccc accccagtct cagccctact 13081 ccactcaagc actatagttg tagcaggaat cttcttactc atccgcttcc accccctagc 13141 agaaaatagc ccactaatcc aaactctaac actatgctta ggcgctatca ccactctgtt 13201 cgcagcagtc tgcgccctta cacaaaatga catcaaaaaa atcgtagcct tctccacttc 13261 aagtcaacta ggactcataa tagttacaat cggcatcaac caaccacacc tagcattcct 13321 gcacatctgt acccacgcct tcttcaaagc catactattt atgtgctccg ggtccatcat 13381 ccacaacctt aacaatgaac aagatattcg aaaaatagga ggactactca aaaccatacc 13441 tctcacttca acctccctca ccattggcag cctagcatta gcaggaatac ctttcctcac 13501 aggtttctac tccaaagacc acatcatcga aaccgcaaac atatcataca caaacgcctg 13561 agccctatct attactctca tcgctacctc cctgacaagc gcctatagca ctcgaataat 13621 tcttctcacc ctaacaggtc aacctcgctt ccccaccctt actaacatta acgaaaataa 13681 ccccacccta ctaaacccca ttaaacgcct ggcagccgga agcctattcg caggatttct 13741 cattactaac aacatttccc ccgcatcccc cttccaaaca acaatccccc tctacctaaa 13801 actcacagcc ctcgctgtca ctttcctagg acttctaaca gccctagacc tcaactacct 13861 aaccaacaaa cttaaaataa aatccccact atgcacattt tatttctcca acatactcgg 13921 attctaccct agcatc