LOCUS AY195751 16566 bp DNA circular PRI 10-JUN-2004 DEFINITION Homo sapiens haplotype E2H mitochondrion, complete genome. ACCESSION AY195751 VERSION AY195751.1 GI:29690476 KEYWORDS . SOURCE mitochondrion Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 16566) AUTHORS Mishmar,D., Ruiz-Pesini,E., Golik,P., Macaulay,V., Clark,A.G., Hosseini,S., Brandon,M., Easley,K., Chen,E., Brown,M.D., Sukernik,R.I., Olckers,A. and Wallace,D.C. TITLE Natural selection shaped regional mtDNA variation in humans JOURNAL Proc. Natl. Acad. Sci. U.S.A. 100 (1), 171-176 (2003) MEDLINE 22406325 PUBMED 12509511 REFERENCE 2 (bases 1 to 16566) AUTHORS Mishmar,D., Ruiz-Pesini,E., Golik,P., Macaulay,V., Clark,A.G., Hosseini,S., Brandon,M., Easley,K., Chen,E., Brown,M.D., Sukernik,R.I., Olckers,A. and Wallace,D.C. TITLE Direct Submission JOURNAL Submitted (11-DEC-2002) MAMMAG, University of California, Irvine, 2nd Floor Hewitt Hall, Irvine, California 92697-3940, USA FEATURES Location/Qualifiers source 1..16566 /organism="Homo sapiens" /organelle="mitochondrion" /mol_type="genomic DNA" /isolation_source="H haplogroup" /db_xref="taxon:9606" /haplotype="E2H" D-loop complement(join(16101..16566,1..191)) tRNA 575..645 /product="tRNA-Phe" rRNA 646..1599 /product="12S ribosomal RNA" tRNA 1600..1668 /product="tRNA-Val" rRNA 1669..3226 /product="16S ribosomal RNA" tRNA 3227..3301 /product="tRNA-Leu" gene 3304..4260 /gene="ND1" CDS 3304..4260 /gene="ND1" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 1" /protein_id="AAO88358.1" /db_xref="GI:29690477" /translation="MPMANLLLLIVPILIAMAFLMLTERKILGYMQLRKGPNVVGPYG LLQPFADAMKLFTKEPLKPATSTITLYITAPTLALTIALLLWTPLPMPNPLVNLNLGL LFILATSSLAVYSILWSGWASNSNYALIGALRAVAQTISYEVTLAIILLSTLLMSGSF NLSTLITTQEHLWLLLPSWPLAMMWFISTLAETNRTPFDLAEGESELVSGFNIEYAAG PFALFFMAEYTNIIMMNTLTTTIFLGTTYDALSPELYTTYFVTKTLLLTSLFLWIRTA YPRFRYDQLMHLLWKNFLPLTLALLMWYVSMPITISSIPPQT" tRNA 4260..4328 /product="tRNA-Ile" tRNA complement(4326..4397) /product="tRNA-Gln" tRNA 4399..4466 /product="tRNA-Met" gene 4467..5510 /gene="ND2" CDS 4467..5510 /gene="ND2" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 2" /protein_id="AAO88359.1" /db_xref="GI:29690478" /translation="MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVL TKKMNPRSTEAAIKYFLTQATASMILLMAILFNNMLSGQWTMTNTTNQYSSLMIMMAM AMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPSLNVSLLLTLSIL SIMAGSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLL LNLNSSTTTLLLSRTWNKLTWLTPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSL IIPTIMATITLLNLYFYLRLIYSTSITLLPMSNNVKMKWQFEHTKPTPFLPTLIALTT LLLPISPFMLMIL" tRNA 5509..5576 /product="tRNA-Trp" tRNA complement(5584..5652) /product="tRNA-Ala" tRNA complement(5654..5726) /product="tRNA-Asn" tRNA complement(5758..5823) /product="tRNA-Cys" tRNA complement(5823..5888) /product="tRNA-Tyr" gene 5901..7442 /gene="COX1" CDS 5901..7442 /gene="COX1" /codon_start=1 /transl_table=2 /product="cytochrome oxidase subunit I" /protein_id="AAO88360.1" /db_xref="GI:29690479" /translation="MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQP GNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSF WLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILG AINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTT FFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWA MMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKW SAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGG FIHWFPLFSGYTLDQTYAKIHFTIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTW NILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEEP VYMKS" tRNA complement(7442..7513) /product="tRNA-Ser" tRNA 7515..7582 /product="tRNA-Asp" gene 7583..8266 /gene="COX2" CDS 7583..8266 /gene="COX2" /codon_start=1 /transl_table=2 /product="cytochrome oxidase subunit II" /protein_id="AAO88361.1" /db_xref="GI:29690480" /translation="MAHAAQVGLQDATSPIMEELITFHDHALMIIFLICFLVLYALFL TLTTKLTNTNISDAQEMETVWTILPAIILVLIALPSLRILYMTDEVNDPSLTIKSIGH QWYWTYEYTDYGGLIFNSYMLPPLFLEPGDLRLLDVDNRVVLPIEAPIRMMITSQDVL HSWAVPTLGLKTDAIPGRLNQTTFTATRPGVYYGQCSEICGANHSFMPIVLELIPLKI FEMGPVFTL" tRNA 8292..8361 /product="tRNA-Lys" gene 8363..8569 /gene="ATP8" CDS 8363..8569 /gene="ATP8" /codon_start=1 /transl_table=2 /product="ATP synthase F0 subunit 8" /protein_id="AAO88362.1" /db_xref="GI:29690481" /translation="MPQLNTTVWPTMITPMLLTLFLITQLKTLNTNYHLPPSPKPMKM KNYNKPWEPKWTKICSLHSLPPQS" gene 8524..9204 /gene="ATP6" CDS 8524..9204 /gene="ATP6" /codon_start=1 /transl_table=2 /product="ATP synthase F0 subunit 6" /protein_id="AAO88363.1" /db_xref="GI:29690482" /translation="MNENLFASFIAPTILGLPAAVLIILFPPLLIPTSKYLINNRLIT TQQWLIKLTSKQMMTMHNTKGRTWSLMLVSLIIFIATTNLLGLLPHSFTPTTQLSMNL AMAIPLWAGAVIMGFRSKIKNALAHFLPQGTPTPLIPMLVIIETISLLIQPMALAVRL TANITAGHLLMHLIGSATLAMSTINLPSTLIIFTILILLTILEIAVALIQAYVFTLLV SLYLHDNT" gene 9204..9984 /gene="COX3" CDS 9204..9984 /gene="COX3" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:9984,aa:TERM) /transl_table=2 /product="cytochrome oxidase subunit III" /protein_id="AAO88364.1" /db_xref="GI:29690483" /translation="MTHQSHAYHMVKPSPWPLTGALSALLMTSGLAMWFHFHSMTLLM LGLLTNTLTMYQWWRDVTRESTYQGHHTPPVQKGLRYGMILFITSEVFFFAGFFWAFY HSSLAPTPQLGGHWPPTGITPLNPLEVPLLNTSVLLASGVSITWAHHSLMENNRNQMI QALLITILLGLYFTLLQASEYFESPFTISDGIYGSTFFVATGFHGLHVIIGSTFLTIC FIRQLMFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIYWWG" tRNA 9988..10055 /product="tRNA-Gly" gene 10056..10401 /gene="ND3" CDS 10056..10401 /gene="ND3" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:10401,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 3" /protein_id="AAO88365.1" /db_xref="GI:29690484" /translation="MNFALILMINTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPM SPARVPFSMKFFLVAITFLLFDLEIALLLPLPWALQTTNLPLMVMSSLLLIIILALSL AYEWLQKGLDWTE" tRNA 10402..10466 /product="tRNA-Arg" gene 10467..10763 /gene="ND4L" CDS 10467..10763 /gene="ND4L" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 4L" /protein_id="AAO88366.1" /db_xref="GI:29690485" /translation="MPLIYMNIMLAFTISLLGMLVYRSHLMSSLLCLEGMMLSLFIMA TLMTLNTHSLLANIVPIAMLVFAACEAAVGLALLVSISNTYGLDYVHNLNLLQC" gene 10757..12134 /gene="ND4" CDS 10757..12134 /gene="ND4" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:12134,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 4" /protein_id="AAO88367.1" /db_xref="GI:29690486" /translation="MLKLIVPTIMLLPLTWLSKKHMIWINTTTHSLIISIIPLLFFNQ INNNLFSCSPTFSSDPLTTPLLMLTTWLLPLTIMASQRHLSSEPLSRKKLYLSMLISL QISLIMTFTATELIMFYIFFETTLIPTLAIITRWGNQPERLNAGTYFLFYTLVGSLPL LIALIYTHNTLGSLNILLLTLTAQELSNSWANNLMWLAYTMAFMVKMPLYGLHLWLPK AHVEAPIAGSMVLAAVLLKLGGYGMMRLTLILNPLTKHMAYPFLVLSLWGMIMTSSIC LRQTDLKSLIAYSSISHMALVVTAILIQTPWSFTGAVILMIAHGLTSSLLFCLANSNY ERTHSRIMILSQGLQTLLPLMAFWWLLASLANLALPPTINLLGELSVLVTTFSWSNIT LLLTGLNMLVTALYSLYMFTTTQWGSLTHHINNMKPSFTRENTLMFMHLSPILLLSLN PDIITGFSS" tRNA 12135..12203 /product="tRNA-His" tRNA 12204..12262 /product="tRNA-Ser" tRNA 12263..12333 /product="tRNA-Leu" gene 12334..14145 /gene="ND5" CDS 12334..14145 /gene="ND5" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 5" /protein_id="AAO88368.1" /db_xref="GI:29690487" /translation="MTMHTTMTTLTLTSLIPPILTTLVNPNKKNSYPHYVKSIVASTF IISLFPTTMFMCLDQEVIISNWHWATTQTTQLSLSFKLDYFSMMFIPVALFVTWSIME FSLWYMNSDPNINQFFKYLLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLISWWYA RADANTAAIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLNANPSLTPLLGLLL AAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFHPLAENSPLIQTL TLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAF FKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSK DHIIETANMSYTNAWALSITLIATSLTSAYSTRMILLTLTGQPRFPTLTNINENNPTL LNPIKRLAAGSLFAGFLITNNISPTSPFQTTIPLYLKLTALAVTFLGLLTALDLNYLT NKLKMKSPLCTFYFSNMLGFYPSITHRTIPYLGLLTSQNLPLLLLDLTWLEKLLPKTI SQHQISTSIITSTQKGMIKLYFLSFFFPLILTLLLIT" gene complement(14146..14670) /gene="ND6" CDS complement(14146..14670) /gene="ND6" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 6" /protein_id="AAO88369.1" /db_xref="GI:29690488" /translation="MMYALFLLSVGLVMGFVGFSSKPSPIYGGLVLIVSGVVGCVIIL NFGGGYMGLMVFLIYLGGMMVVFGYTTAMAIEEYPEAWGSGVEVLVSVLVGLAMEVGL VLWVKEYDGVVVVVNFNSVGSWMIYEGEGSGLIREDPIGAGALYDYGRWLVVVTGWTL FVGVYIVIEIARGN" tRNA complement(14671..14739) /product="tRNA-Glu" gene 14744..15878 /gene="cytb" CDS 14744..15878 /gene="cytb" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:15878,aa:TERM) /transl_table=2 /product="cytochrome b" /protein_id="AAO88370.1" /db_xref="GI:29690489" /translation="MTPMRKTNPLMKLINHSFIDLPTPSNISAWWNFGSLLGACLILQ ITTGLFLAMHYSPDASTAFSSIAHITRDVNYGWIIRYLHANGASMFFICLFLHIGRGL YYGSFLYSETWNIGIILLLATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDL VQWIWGGYSVDSPTLTRFFTFHFILPFIIAALAALHLLFLHETGSNNPLGITSHSDKI TFHPYYTIKDALGLLLFLLSLMTLTLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLF AYTILRSVPNKLGGVLALLLSILILAMIPILHMSKQQSMMFRPLSQSLYWLLAADLLI LTWIGGQPVSYPFTIIGQVASVLYFTTILILMPTISLIENKMLK" tRNA 15885..15950 /product="tRNA-Thr" tRNA complement(15952..16020) /product="tRNA-Pro" ORIGIN 1 gatcacaggt ctatcaccct attaaccact cacgggagct ctccatgcat ttggtatttt 61 cgtctggggg gcatgcacgc gatagcattg cgagacgctg gagccggagc accctatgtc 121 gcagtatctg tctttgattc ctgcctcatc ccattattta tcgcacctac gttcaatatt 181 acaggcgaac atacctacta aagtgtgtta attaattaat gcttgtagga cataataata 241 acaattgaat gtctgcacag ccgctttcca cacagacatc ataacaaaaa atttccacca 301 aaccccccct cccccgcttc tggccacagc acttaaacac atctctgcca aaccccaaaa 361 acaaagaacc ctaacaccag cctaaccaga tttcaaattt tatcttttgg cggtatgcac 421 ttttaacagt caccccccaa ctaacacatt attttcccct cccactccca tactactaat 481 ctcatcaata caacccccgc ccatcctacc cagcacacac accgctgcta accccatacc 541 ccgaaccaac caaaccccaa agacaccccc cacagtttat gtagcttacc tcctcaaagc 601 aatacactga aaatgtttag acgggctcac atcaccccat aaacaaatag gtttggtcct 661 agcctttcta ttagctctta gtaagattac acatgcaagc atccccgttc cagtgagttc 721 accctctaaa tcaccacgat caaaagggac aagcatcaag cacgcagcaa tgcagctcaa 781 aacgcttagc ctagccacac ccccacggga aacagcagtg attaaccttt agcaataaac 841 gaaagtttaa ctaagctata ctaaccccag ggttggtcaa tttcgtgcca gccaccgcgg 901 tcacacgatt aacccaagtc aatagaagcc ggcgtaaaga gtgttttaga tcacccccgc 961 cccaataaag ctaaaactca cctgagttgt aaaaaactcc agttgacaca aaatagacta 1021 cgaaagtggc tttaacatat ctgaacacac aatagctaag acccaaactg ggattagata 1081 ccccactatg cttagcccta aacctcaaca gttaaatcaa caaaactgct cgccagaaca 1141 ctacgagcca cagcttaaaa ctcaaaggac ctggcggtgc ttcatatccc tctagaggag 1201 cctgttctgt aatcgataaa ccccgatcaa cctcaccacc tcttgctcag cctatatacc 1261 gccatcttca gcaaaccctg atgaaggcta caaagtaagc gcaagtaccc acgtaaagac 1321 gttaggtcaa ggtgtagccc atgaggtggc aagaaatggg ctacattttc taccccagaa 1381 aactacgata gcccttatga aacttaaggg tcgaaggtgg atttagcagt aaactgagag 1441 tagagtgctt agttgaacag ggccctgaag cgcgtacaca ccgcccgtca ccctcctcaa 1501 gtatacttca aaggacattt aactaaaacc cctacgcatt tatatagagg agacaagtcg 1561 taacatggta agtgtactgg aaagtgcact tggacgaacc agagtgtagc ttaacacaaa 1621 gcacccaact tacacttagg agatttcaac ttaacttgac cgctctgagc taaacctagc 1681 cccaaaccca ctccacctta ctaccagaca accttagcca aaccatttac ccaaataaag 1741 tataggcgat agaaattgaa acctggcgca atagatatag taccgcaagg gaaagatgaa 1801 aaattataac caagcataat atagcaagga ctaaccccta taccttctgc ataatgaatt 1861 aactagaaat aactttgcaa ggagagccaa agctaagacc cccgaaacca gacgagctac 1921 ctaagaacag ctaaaagagc acacccgtct atgtagcaaa atagtgggaa gatttatagg 1981 tagaggcgac aaacctaccg agcctggtga tagctggttg tccaagatag aatcttagtt 2041 caactttaaa tttgcccaca gaaccctcta aatccccttg taaatttaac tgttagtcca 2101 aagaggaaca gctctttgga cactaggaaa aaaccttgta gagagagtaa aaaatttaac 2161 acccatagta ggcctaaaag cagccaccaa ttaagaaagc gttcaagctc aacacccact 2221 acctaaaaaa tcccaaacat ataactgaac tcctcacacc caattggacc aatctatcac 2281 cctatagaag aactaatgtt agtataagta acatgaaaac attctcctcc gcataagcct 2341 gcgtcagatt aaaacactga actgacaatt aacagcccaa tatctacaat caaccaacaa 2401 gtcattatta ccctcactgt caacccaaca caggcatgct cataaggaaa ggttaaaaaa 2461 agtaaaagga actcggcaaa tcttaccccg cctgtttacc aaaaacatca cctctagcat 2521 caccagtatt agaggcaccg cctgcccagt gacacatgtt taacggccgc ggtaccctaa 2581 ccgtgcaaag gtagcataat cacttgttcc ttaaataggg acctgtatga atggctccac 2641 gagggttcag ctgtctctta cttttaacca gtgaaattga cctgcccgtg aagaggcggg 2701 cataacacag caagacgaga agaccctatg gagctttaat ttattaatgc aaacagtacc 2761 taacaaaccc acaggtccta aactaccaaa cctgcattaa aaatttcggt tggggcgacc 2821 tcggagcaga acccaacctc cgagcagtac atgctaagac ttcaccagtc aaagcgaact 2881 actatactca attgatccaa taacttgacc aacggaacaa gttaccctag ggataacagc 2941 gcaatcctat tctagagtcc atatcaacaa tagggtttac gacctcgatg ttggatcagg 3001 acatcccgat ggtgcagccg ctattaaagg ttcgtttgtt caacgattaa agtcctacgt 3061 gatctgagtt cagaccggag taatccaggt cggtttctat ctacttcaaa ttcctccctg 3121 tacgaaagga caagagaaat aaggcctact tcacaaagcg ccttcccccg taaatgatat 3181 catctcaact tagtattata cccacaccca cccaagaaca gggtttgtta agatggcaga 3241 gcccggtaat cgcataaaac ttaaaacttt acagtcagag gttcaattcc tcttcttaac 3301 aacataccca tggccaacct cctactcctc attgtaccca ttctaatcgc aatggcattc 3361 ctaatgctta ccgaacgaaa aattctaggc tatatacaac tacgcaaagg ccccaacgtt 3421 gtaggcccct acgggctact acaacccttc gctgacgcca taaaactctt caccaaagag 3481 cccctaaaac ccgccacatc taccatcacc ctctacatca ccgccccgac cttagctctc 3541 accatcgctc ttctactatg aacccccctc cccataccca accccctggt caacctcaac 3601 ctaggcctcc tatttattct agccacctct agcctagccg tttactcaat cctctgatca 3661 gggtgagcat caaactcaaa ctacgccctg atcggcgcac tgcgagcagt agcccaaaca 3721 atctcatatg aagtcaccct agccatcatt ctactatcaa cattactaat aagtggctcc 3781 tttaacctct ccacccttat cacaacacaa gaacacctct gattactcct gccatcatga 3841 cccttggcca taatatgatt tatctccaca ctagcagaga ccaaccgaac ccccttcgac 3901 cttgccgaag gggagtccga actagtctca ggcttcaaca tcgaatacgc cgcaggcccc 3961 ttcgccctat tcttcatagc cgaatacaca aacattatta taataaacac cctcaccact 4021 acaatcttcc taggaacaac atatgacgca ctctcccctg aactctacac aacatatttt 4081 gtcaccaaga ccctacttct aacctccctg ttcttatgaa ttcgaacagc atacccccga 4141 ttccgctacg accaactcat acacctccta tgaaaaaact tcctaccact caccctagca 4201 ttacttatat gatatgtctc catacccatt acaatctcca gcattccccc tcaaacctaa 4261 gaaatatgtc tgataaaaga gttactttga tagagtaaat aataggagct taaaccccct 4321 tatttctagg actatgagaa tcgaacccat ccctgagaat ccaaaattct ccgtgccacc 4381 tatcacaccc catcctaaag taaggtcagc taaataagct atcgggccca taccccgaaa 4441 atgttggtta tacccttccc gtactaatta atcccctggc ccaacccgtc atctactcta 4501 ccatctttgc aggcacactc atcacagcgc taagctcgca ctgatttttt acctgagtag 4561 gcctagaaat aaacatgcta gcttttattc cagttctaac caaaaaaata aaccctcgtt 4621 ccacagaagc tgccatcaag tatttcctca cgcaagcaac cgcatccata atccttctaa 4681 tagctatcct cttcaacaat atactctccg gacaatgaac cataaccaat actaccaatc 4741 aatactcatc attaataatc ataatggcta tagcaataaa actaggaata gccccctttc 4801 acttctgagt cccagaggtt acccaaggca cccctctgac atccggcctg cttcttctca 4861 catgacaaaa actagccccc atctcaatca tataccaaat ctctccctca ctaaacgtaa 4921 gccttctcct cactctctca atcttatcca tcatagcagg cagttgaggt ggattaaacc 4981 aaacccagct acgcaaaatc ttagcatact cctcaattac ccacatagga tgaataatag 5041 cagttctacc gtacaaccct aacataacca ttcttaattt aactatttat attatcctaa 5101 ctactaccgc attcctacta ctcaacttaa actccagcac cacgacccta ctactatctc 5161 gcacctgaaa caagctaaca tgactaacac ccttaattcc atccaccctc ctctccctag 5221 gaggcctgcc cccgctaacc ggctttttgc ccaaatgggc cattatcgaa gaattcacaa 5281 aaaacaatag cctcatcatc cccaccatca tagccaccat caccctcctt aacctctact 5341 tctacctacg cctaatctac tccacctcaa tcacactact ccccatatct aacaacgtaa 5401 aaataaaatg acagtttgaa catacaaaac ccaccccatt cctccccaca ctcatcgccc 5461 ttaccacgct actcctacct atctcccctt ttatactaat aatcttatag aaatttaggt 5521 taaatacaga ccaagagcct tcaaagccct cagtaagttg caatacttaa tttctgtaac 5581 agctaaggac tgcaaaaccc cactctgcat caactgaacg caaatcagcc actttaatta 5641 agctaagccc ttactagacc aatgggactt agacccacaa acacttagtt aacagctaag 5701 caccctaatc aactggcttc aatctacttc tcccgccgcc gggaaaaaag gcgggagaag 5761 ccccggcagg tttgaagctg cttcttcgaa tttgcaattc aatatgaaaa tcacctcgga 5821 gctggtaaaa agaggcctaa cccctgtctt tagatttaca gtccaatgct tcactcagcc 5881 attttacctc acccccactg atgttcgccg accgttgact attctctaca aaccacaaag 5941 acattggaac actataccta ttattcggcg catgagctgg agtcctaggc acagctctaa 6001 gcctccttat tcgagccgag ctgggccagc caggcaacct tctaggtaac gaccacatct 6061 acaacgttat cgtcacagcc catgcatttg taataatctt cttcatagta atacccatca 6121 taatcggagg ctttggcaac tgactagttc ccctaataat cggtgccccc gatatggcgt 6181 ttccccgcat aaacaacata agcttctgac tcttacctcc ctctctccta ctcctgctcg 6241 catctgctat agtggaggcc ggagcaggaa caggttgaac agtctaccct cccttagcag 6301 ggaactactc ccaccctgga gcctccgtag acctaaccat cttctcctta cacctagcag 6361 gtgtctcctc tatcttaggg gccatcaatt tcatcacaac aattatcaat ataaaacccc 6421 ctgccataac ccaataccaa acgcccctct tcgtctgatc cgtcctaatc acagcagtcc 6481 tacttctcct atctctccca gtcctagctg ctggcatcac tatactacta acagaccgca 6541 acctcaacac caccttcttc gaccccgccg gaggaggaga ccccattcta taccaacacc 6601 tattctgatt tttcggtcac cctgaagttt atattcttat cctaccaggc ttcggaataa 6661 tctcccatat tgtaacttac tactccggaa aaaaagaacc atttggatac ataggtatgg 6721 tctgagctat gatatcaatt ggcttcctag ggtttatcgt gtgagcacac catatattta 6781 cagtaggaat agacgtagac acacgagcat atttcacctc cgctaccata atcatcgcta 6841 tccccaccgg cgtcaaagta tttagctgac tcgccacact ccacggaagc aatatgaaat 6901 gatctgctgc agtgctctga gccctaggat tcatctttct tttcaccgta ggtggcctga 6961 ctggcattgt attagcaaac tcatcactag acatcgtact acacgacacg tactacgttg 7021 tagcccactt ccactatgtc ctatcaatag gagctgtatt tgccatcata ggaggcttca 7081 ttcactgatt tcccctattc tcaggctaca ccctagacca aacctacgcc aaaatccatt 7141 tcactatcat attcatcggc gtaaatctaa ctttcttccc acaacacttt ctcggcctat 7201 ccggaatgcc ccgacgttac tcggactacc ccgatgcata caccacatga aacatcctat 7261 catctgtagg ctcattcatt tctctaacag cagtaatatt aataattttc atgatttgag 7321 aagccttcgc ttcgaagcga aaagtcctaa tagtagaaga accctccata aacctggagt 7381 gactatatgg atgcccccca ccctaccaca cattcgaaga acccgtatac ataaaatcta 7441 gacaaaaaag gaaggaatcg aaccccccaa agctggtttc aagccaaccc catggcctcc 7501 atgacttttt caaaaaggta ttagaaaaac catttcataa ctttgtcaaa gttaaattat 7561 aggctaaatc ctatatatct taatggcaca tgcagcgcaa gtaggtctac aagacgctac 7621 ttcccctatc atagaagagc ttatcacctt tcatgatcac gccctcataa tcattttcct 7681 tatctgcttc ctagtcctgt atgccctttt cctaacactc acaacaaaac taactaatac 7741 taacatctca gacgctcagg aaatagaaac cgtctgaact atcctgcccg ccatcatcct 7801 agtcctcatc gccctcccat ccctacgcat cctttacata acagacgagg tcaacgatcc 7861 ctcccttacc atcaaatcaa ttggccacca atggtactga acctacgagt acaccgacta 7921 cggcggacta atcttcaact cctacatact tcccccatta ttcctagaac caggcgacct 7981 gcgactcctt gacgttgaca atcgagtagt actcccgatt gaagccccca ttcgtataat 8041 aattacatca caagacgtct tgcactcatg agctgtcccc acattaggct taaaaacaga 8101 tgcaattccc ggacgtctaa accaaaccac tttcaccgct acacgaccgg gggtatacta 8161 cggtcaatgc tctgaaatct gtggagcaaa ccacagtttc atgcccatcg tcctagaatt 8221 aattccccta aaaatctttg aaatagggcc cgtatttacc ctataacacc ccctctaccc 8281 cctctagagc ccactgtaaa gctaacttag cattaacctt ttaagttaaa gattaagaga 8341 accaacacct ctttacagtg aaatgcccca actaaatact accgtatggc ccaccataat 8401 tacccccata ctccttacac tattcctcat cacccaacta aaaacattaa acacaaacta 8461 ccacctacct ccctcaccaa agcccataaa aataaaaaat tataacaaac cctgagaacc 8521 aaaatgaacg aaaatctgtt cgcttcattc attgccccca caatcctagg cctacccgcc 8581 gcagtactga tcattctatt tccccctcta ttgatcccca cctccaaata tctcatcaac 8641 aaccgactaa tcaccaccca acaatgacta atcaaactaa cctcaaaaca aatgataacc 8701 atacacaaca ctaaaggacg aacctgatct cttatactag tatccttaat catttttatt 8761 gccacaacta acctcctcgg actcctgcct cactcattta caccaaccac ccaactatct 8821 ataaacctag ccatggccat ccccttatga gcgggcgcag tgattatagg ctttcgctct 8881 aagattaaaa atgccctagc ccacttctta ccacaaggca cacctacacc ccttatcccc 8941 atactagtta ttatcgaaac catcagccta ctcattcaac caatagccct ggccgtacgc 9001 ctaaccgcta acattactgc aggccaccta ctcatgcacc taattggaag cgccacccta 9061 gcaatatcaa ccattaacct tccctctaca cttatcatct tcacaattct aattctactg 9121 actatcctag aaatcgctgt cgccttaatc caagcctacg ttttcacact tctagtaagc 9181 ctctacctgc acgacaacac ataatgaccc accaatcaca tgcctatcat atagtaaaac 9241 ccagcccatg acccctaaca ggggccctct cagccctcct aatgacctcc ggcctagcca 9301 tgtgatttca cttccactcc ataacgctcc tcatactagg cctactaacc aacacactaa 9361 ccatatacca atgatggcgc gatgtaacac gagaaagcac ataccaaggc caccacacac 9421 cacctgtcca aaaaggcctt cgatacggga taatcctatt tattacctca gaagtttttt 9481 tcttcgcagg atttttctga gccttttacc actccagcct agcccccacc ccccaattag 9541 gagggcactg gcccccaaca ggcatcaccc cgctaaatcc cctagaagtc ccactcctaa 9601 acacatccgt attactcgca tcaggagtat caatcacctg agctcaccat agtctaatag 9661 aaaacaaccg aaaccaaata attcaagcac tgcttattac aattttactg ggtctctatt 9721 ttaccctcct acaagcctca gagtacttcg agtctccctt caccatttcc gacggcatct 9781 acggctcaac attttttgta gccacaggct tccacggact tcacgtcatt attggctcaa 9841 ctttcctcac tatctgcttc atccgccaac taatatttca ctttacatcc aaacatcact 9901 ttggctttga agccgccgcc tgatactggc attttgtaga tgtggtttga ctatttctgt 9961 atgtctccat ctattgatga gggtcttact cttttagtat aaatagtacc gttaacttcc 10021 aattaactag ttttgacaac attcaaaaaa gagtaataaa cttcgcctta attttaataa 10081 tcaacaccct cctagcctta ctactaataa ttattacatt ttgactacca caactcaacg 10141 gctacataga aaaatccacc ccttacgagt gcggcttcga ccctatatcc cccgcccgcg 10201 tccctttctc cataaaattc ttcttagtag ctattacctt cttattattt gatctagaaa 10261 ttgccctcct tttaccccta ccatgagccc tacaaacaac taacctgcca ctaatagtta 10321 tgtcatccct cttattaatc atcatcctag ccctaagtct ggcctatgag tgactacaaa 10381 aaggattaga ctgaaccgaa ttggtatata gtttaaacaa aacgaatgat ttcgactcat 10441 taaattatga taatcatatt taccaaatgc ccctcattta cataaatatt atactagcat 10501 ttaccatctc acttctagga atactagtat atcgctcaca cctcatatcc tccctactat 10561 gcctagaagg aataatacta tcgctgttca ttatagctac tctcataacc ctcaacaccc 10621 actccctctt agccaatatt gtgcctattg ccatactagt ctttgccgcc tgcgaagcag 10681 cggtgggcct agccctacta gtctcaatct ccaacacata tggcctagac tacgtacata 10741 acctaaacct actccaatgc taaaactaat cgtcccaaca attatattac taccactgac 10801 atgactttcc aaaaaacaca taatttgaat caacacaacc acccacagcc taattattag 10861 catcatccct ctactatttt ttaaccaaat caacaacaac ctatttagct gttccccaac 10921 cttttcctcc gaccccctaa caacccccct cctaatacta actacctgac tcctacccct 10981 cacaatcatg gcaagccaac gccacttatc cagtgaacca ctatcacgaa aaaaactcta 11041 cctctctata ctaatctccc tacaaatctc cttaattata acattcacag ccacagaact 11101 aatcatattt tatatcttct tcgaaaccac acttatcccc accttggcta tcatcacccg 11161 atgaggcaac cagccagaac gcctgaacgc aggcacatac ttcctattct acaccctagt 11221 aggctccctt cccctactca tcgcactaat ttacactcac aacaccctag gctcactaaa 11281 cattctacta ctcactctca ctgcccaaga actatcaaac tcctgagcca acaacttaat 11341 atgactagct tacacaatag cttttatagt aaagatacct ctttacggac tccacttatg 11401 actccctaaa gcccatgtcg aagcccccat cgctgggtca atagtacttg ccgcagtact 11461 cttaaaacta ggcggctatg gtataatacg cctcacactc attctcaacc ccctgacaaa 11521 acacatagcc taccccttcc ttgtactatc cctatgaggc ataattataa caagctccat 11581 ctgcctacga caaacagacc taaaatcgct cattgcatac tcttcaatca gccacatagc 11641 cctcgtagta acagccattc tcatccaaac cccctgaagc ttcaccggcg cagtcattct 11701 cataatcgcc cacgggctta catcctcatt actattctgc ctagcaaact caaactacga 11761 acgcactcac agtcgcatca taatcctctc tcaaggactt caaactctac tcccactaat 11821 agctttttga tgacttctag caagcctcgc taacctcgcc ttacccccca ctattaacct 11881 actgggagaa ctctctgtgc tagtaaccac gttctcctga tcaaatatca ctctcctact 11941 tacaggactc aacatactag tcacagccct atactccctc tacatattta ccacaacaca 12001 atggggctca ctcacccacc acattaacaa cataaaaccc tcattcacac gagaaaacac 12061 cctcatgttc atacacctat cccccattct cctcctatcc ctcaaccccg acatcattac 12121 cgggttttcc tcttgtaaat atagtttaac caaaacatca gattgtgaat ctgacaacag 12181 aggcttacga ccccttattt accgagaaag ctcacaagaa ctgctaactc atgcccccat 12241 gtctaacaac atggctttct caacttttaa aggataacag ctatccattg gtcttaggcc 12301 ccaaaaattt tggtgcaact ccaaataaaa gtaataacca tgcacactac tataaccacc 12361 ctaaccctga cttccctaat tccccccatc cttaccaccc tcgttaaccc taacaaaaaa 12421 aactcatacc cccattatgt aaaatccatt gtcgcatcca cctttattat cagtctcttc 12481 cccacaacaa tattcatgtg cctagaccaa gaagttatta tctcgaactg acactgagcc 12541 acaacccaaa caacccagct ctccctaagc ttcaaactag actacttctc cataatattc 12601 atccctgtag cattgttcgt tacatggtcc atcatagaat tctcactgtg atatataaac 12661 tcagacccaa acattaatca gttcttcaaa tatctactca tcttcctaat taccatacta 12721 atcttagtta ccgctaacaa cctattccaa ctgttcatcg gctgagaggg cgtaggaatt 12781 atatccttct tgctcatcag ttgatgatac gcccgagcag atgccaacac agcagccatt 12841 caagcaatcc tatacaaccg tatcggcgat atcggtttca tcctcgcctt agcatgattt 12901 atcctacact ccaactcatg agacccacaa caaatagccc ttctaaacgc taatccaagc 12961 ctcaccccac tactaggcct cctcctagca gcagcaggca aatcagccca attaggtctc 13021 cacccctgac tcccctcagc catagaaggc cccaccccag tctcagccct actccactca 13081 agcactatag ttgtagcagg aatcttctta ctcatccgct tccaccccct agcagaaaat 13141 agcccactaa tccaaactct aacactatgc ttaggcgcta tcaccactct gttcgcagca 13201 gtctgcgccc ttacacaaaa tgacatcaaa aaaatcgtag ccttctccac ttcaagtcaa 13261 ctaggactca taatagttac aatcggcatc aaccaaccac acctagcatt cctgcacatc 13321 tgtacccacg ccttcttcaa agccatacta tttatgtgct ccgggtccat catccacaac 13381 cttaacaatg aacaagatat tcgaaaaata ggaggactac tcaaaaccat acctctcact 13441 tcaacctccc tcaccattgg cagcctagca ttagcaggaa tacctttcct cacaggtttc 13501 tactccaaag accacatcat cgaaaccgca aacatatcat acacaaacgc ctgagcccta 13561 tctattactc tcatcgctac ctccctgaca agcgcctata gcactcgaat aattcttctc 13621 accctaacag gtcaacctcg cttccccacc cttactaaca ttaacgaaaa taaccccacc 13681 ctactaaacc ccattaaacg cctggcagcc ggaagcctat tcgcaggatt tctcattact 13741 aacaacattt cccccacatc ccccttccaa acaacaatcc ccctctacct aaaactcaca 13801 gccctcgctg tcactttcct aggacttcta acagccctag acctcaacta cctaaccaac 13861 aaacttaaaa taaaatcccc actatgcaca ttttatttct ccaacatact cggattctac 13921 cctagcatca cacaccgcac aatcccctat ctaggccttc ttacgagcca aaacctgccc 13981 ctactcctcc tagacctaac ctgactagaa aagctattac ctaaaacaat ttcacagcac 14041 caaatctcca cctccatcat cacctcaacc caaaaaggca taattaaact ttacttcctc 14101 tctttcttct tcccactcat cctaacccta ctcctaatca cataacctat tcccccgagc 14161 aatctcaatt acaatatata caccaacaaa caatgttcaa ccagtaacta ctactaatca 14221 acgcccataa tcatacaaag cccccgcacc aataggatcc tcccgaatca accctgaccc 14281 ctctccttca taaattattc agcttcctac actattaaag tttaccacaa ccaccacccc 14341 atcatactct ttcacc