LOCUS AY195749 16564 bp DNA circular PRI 10-JUN-2004 DEFINITION Homo sapiens haplotype Na1B mitochondrion, complete genome. ACCESSION AY195749 VERSION AY195749.2 GI:48596141 KEYWORDS . SOURCE mitochondrion Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 16564) AUTHORS Mishmar,D., Ruiz-Pesini,E., Golik,P., Macaulay,V., Clark,A.G., Hosseini,S., Brandon,M., Easley,K., Chen,E., Brown,M.D., Sukernik,R.I., Olckers,A. and Wallace,D.C. TITLE Natural selection shaped regional mtDNA variation in humans JOURNAL Proc. Natl. Acad. Sci. U.S.A. 100 (1), 171-176 (2003) MEDLINE 22406325 PUBMED 12509511 REFERENCE 2 (bases 1 to 16564) AUTHORS Mishmar,D., Ruiz-Pesini,E., Golik,P., Macaulay,V., Clark,A.G., Hosseini,S., Brandon,M., Easley,K., Chen,E., Brown,M.D., Sukernik,R.I., Olckers,A. and Wallace,D.C. TITLE Direct Submission JOURNAL Submitted (11-DEC-2002) MAMMAG, University of California, Irvine, 2nd Floor Hewitt Hall, Irvine, California 92697-3940, USA REFERENCE 3 (bases 1 to 16564) AUTHORS Mishmar,D., Ruiz-Pesini,E., Golik,P., Macaulay,V., Clark,A.G., Hosseini,S., Brandon,M., Easley,K., Chen,E., Brown,M.D., Sukernik,R.I., Olckers,A. and Wallace,D.C. TITLE Direct Submission JOURNAL Submitted (10-JUN-2004) MAMMAG, University of California, Irvine, 2nd Floor Hewitt Hall, Irvine, California 92697-3940, USA REMARK Sequence update by submitter COMMENT On Jun 10, 2004 this sequence version replaced gi:29690448. FEATURES Location/Qualifiers source 1..16564 /organism="Homo sapiens" /organelle="mitochondrion" /mol_type="genomic DNA" /isolation_source="Native American" /isolation_source="B haplogroup Native American" /db_xref="taxon:9606" /haplotype="Na1B" D-loop complement(join(16098..16564,1..191)) tRNA 580..650 /product="tRNA-Phe" rRNA 651..1604 /product="12S ribosomal RNA" tRNA 1605..1673 /product="tRNA-Val" rRNA 1674..3231 /product="16S ribosomal RNA" tRNA 3232..3306 /product="tRNA-Leu" gene 3309..4265 /gene="ND1" CDS 3309..4265 /gene="ND1" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 1" /protein_id="AAO88332.1" /db_xref="GI:29690449" /translation="MPMANLLLLIVPILIAMAFLMLTERKILGYMQLRKGPNVVGPYG LLQPFADAMKLFTKEPLKPATSTITLYITAPTLALTVALLLWTPLPMPNPLVNLNLGL LFILATSSLAVYSILWSGWASNSNYALIGALRAVAQTISYEVTLAIILLSTLLMSGSF NLSTLITTQEHLWLLLPSWPLAMMWFISTLAETNRTPFDLAEGESELVSGFNIEYAAG PFALFFMAEYTNIIMMNTLTTTIFLGTTYDALSPELYTTYFVTKTLLLTSLFLWVRTA YPRFRYDQLMHLLWKNFLPLTLALLMWYVSMPITISSIPPQT" tRNA 4265..4333 /product="tRNA-Ile" tRNA complement(4331..4402) /product="tRNA-Gln" tRNA 4404..4471 /product="tRNA-Met" gene 4472..5515 /gene="ND2" CDS 4472..5515 /gene="ND2" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 2" /protein_id="AAO88333.1" /db_xref="GI:29690450" /translation="MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVL TKKMNPRSTEAAIKYFLTQATASMILLMAILFNNMLSGQWTMTNTTNQYSSLMIMMAM AMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPSLNVSLLLTLSIL SIMAGSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLL LNLNSSTTTLLLSRTWNKLTWLTPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSL IIPTIMATITLLNLYFYLRLIYSTSITLLPMSNNVKMKWQFEHTKPTPFLPTLIALTT LLLPISPFMLMIL" tRNA 5514..5581 /product="tRNA-Trp" tRNA complement(5589..5657) /product="tRNA-Ala" tRNA complement(5659..5731) /product="tRNA-Asn" tRNA complement(5763..5828) /product="tRNA-Cys" tRNA complement(5828..5893) /product="tRNA-Tyr" gene 5906..7447 /gene="COX1" CDS 5906..7447 /gene="COX1" /codon_start=1 /transl_table=2 /product="cytochrome oxidase subunit I" /protein_id="AAO88334.2" /db_xref="GI:48596142" /translation="MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQP GNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSF WLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILG AINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTT FFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWA MMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKW SAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGG FIHWFPLFSGYTLDQTYAKIHFTIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTW NILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEEP VYMKS" tRNA complement(7447..7518) /product="tRNA-Ser" tRNA 7520..7587 /product="tRNA-Asp" gene 7588..8271 /gene="COX2" CDS 7588..8271 /gene="COX2" /codon_start=1 /transl_table=2 /product="cytochrome oxidase subunit II" /protein_id="AAO88335.1" /db_xref="GI:29690452" /translation="MAHAAQVGLQDATSPIMEELITFHDHALMIIFLICFLVLYALFL TLTTKLTNTNISDAQEMETVWTILPAIILVLIALPSLRILYMTDEVNDPSLTIKSIGH QWYWTYEYTDYGGLIFNSYMLPPLFLEPGDLRLLDVDNRVVLPIEAPIRMMITSQDVL HSWAVPTLGLKTDAIPGRLNQTTFTATRPGVYYGQCSEICGANHSFMPIVLELIPLKI FEMGPVFTL" tRNA 8289..8358 /product="tRNA-Lys" gene 8360..8566 /gene="ATP8" CDS 8360..8566 /gene="ATP8" /codon_start=1 /transl_table=2 /product="ATP synthase F0 subunit 8" /protein_id="AAO88336.1" /db_xref="GI:29690453" /translation="MPQLNTTVWPTMITPMLLTLFLITQLKMLNTNYHLPPSPKPMKM KNYNKPWEPKWTKICSLHSLPPQS" gene 8521..9201 /gene="ATP6" CDS 8521..9201 /gene="ATP6" /codon_start=1 /transl_table=2 /product="ATP synthase F0 subunit 6" /protein_id="AAO88337.1" /db_xref="GI:29690454" /translation="MNENLFASFIAPTILGLPAAVLIILFPPLLIPTSKYLINNRLIT TQQWLIKLTSKQMMTMHNTKGRTWSLMLVSLIIFIATTNLLGLLPHSFTPTTQLSMNL AMAIPLWAGAVIMGLRSKIKNALAHFLPQGTPTPLIPMLVIIETISLLIQPMALAVRL TANITAGHLLMHLIGSATLAMSTINLPSTLIIFTILILLTILEIAVALIQAYVFTLLV SLYLHDNT" gene 9201..9981 /gene="COX3" CDS 9201..9981 /gene="COX3" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:9981,aa:TERM) /transl_table=2 /product="cytochrome oxidase subunit III" /protein_id="AAO88338.1" /db_xref="GI:29690455" /translation="MTHQSHAYHMVKPSPWPLTGALSALLMTSGLAMWFHFHSMTLLM LGLLTNTLTMYQWWRDVTRESTYQGHHTPPVQKGLRYGMILFITSEVFFFAGFFWAFY HSSLAPTPQLGGHWPPTGITPLNPLEVPLLNTSVLLASGVSITWAHHSLMENNRNQTI QALLITILLGLYFTLLQASEYFESPFTISDGIYGSTFFVATGFHGLHVIIGSTFLTIC FIRQLMFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIYWWG" tRNA 9985..10052 /product="tRNA-Gly" gene 10053..10398 /gene="ND3" CDS 10053..10398 /gene="ND3" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:10398,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 3" /protein_id="AAO88339.1" /db_xref="GI:29690456" /translation="MNFALILMINTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPM SPARVPFSMKFFLVAITFLLFDLEIALLLPLPWALQTTNLPLMVMSSLLLIIILALSL AYEWLQKGLDWTE" tRNA 10399..10463 /product="tRNA-Arg" gene 10464..10760 /gene="ND4L" CDS 10464..10760 /gene="ND4L" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 4L" /protein_id="AAO88340.1" /db_xref="GI:29690457" /translation="MPLIYMNIMLAFTISLLGMLVYRSHLMSSLLCLEGMMLSLFIMA TLMTLNTHSLLANIVPIAMLVFAACEAAVGLALLVSISNTYGLDYVHNLNLLQC" gene 10754..12131 /gene="ND4" CDS 10754..12131 /gene="ND4" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:12131,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 4" /protein_id="AAO88341.1" /db_xref="GI:29690458" /translation="MLKLIVPTIMLLPLTWLSKKHMIWINTTTHSLIISIIPLLFFNQ INNNLFSCSPTFSSDPLTTPLLMLTTWLLPLTIMASQRHLSSEPLSRKKLYLSMLISL QISLIMTFTATELIMFYIFFETTLIPTLAIITRWGNQSERLNAGTYFLFYTLVGSLPL LIALIYTHNTLGSLNILLLTLTAQELSNSWANNLMWLAYTMAFMVKMPLYGLHLWLPK AHVEAPIAGSMVLAAVLLKLGGYGMMRLTLILNPLTKHMAYPFLVLSLWGMIMTSSIC LRQTDLKSLIAYSSISHMALVVTAILIQTPWSFTGAVILMIAHGLTSSLLFCLANSNY ERTHSRIMILSQGLQTLLPLMAFWWLLASLANLALPPTINLLGELSVLVTTFSWSNIT LLLTGLNMLVTALYSLYMFTTTQWGSLTHHINNMKPSFTRENTLMFMHLSPILLLSLN PDIITGFSS" tRNA 12132..12200 /product="tRNA-His" tRNA 12201..12259 /product="tRNA-Ser" tRNA 12260..12330 /product="tRNA-Leu" gene 12331..14142 /gene="ND5" CDS 12331..14142 /gene="ND5" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 5" /protein_id="AAO88342.1" /db_xref="GI:29690459" /translation="MTMHTTMTTLTLTSLIPPILTTLVNPNKKNSYPHYVKSIVASTF IISLFPTTMFMCLDQEVIISNWHWATTQTTQLSLSFKLDYFSMMFIPVALFVTWSIME FSLWYMNSDPNINQFFKYLLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLISWWYA RADANTAAIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLNANPSLTPLLGLLL AAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFHPLAENSPLIQTL TLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAF FKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSK DHIIETANMSYTNAWALSITLIATSLTSAYSTRMILLTLTGQPRFPTLTNINENNPTL LNPIKRLAAGSLFAGFLITNNISPASPFQTTIPLYLKLTALAVTFLGLLTALDLNYLT NKLKMKSPLCTFYFSNMLGFYPSITHRTIPYLGLLTSQNLPLLLLDLTWLEKLLPKTI SQHQISTSIITSTQKGMIKLYFLSFFFPLILTLLLIT" gene complement(14143..14667) /gene="ND6" CDS complement(14143..14667) /gene="ND6" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 6" /protein_id="AAO88343.1" /db_xref="GI:29690460" /translation="MMYALFLLSVGLVMGFVGFSSKPSPIYGGLVLIVSGVVGCVIIL NFGGGYMGLMVFLIYLGGMMVVFGYTTAMAIEEYPEAWGSGVEVLVSVLVGLAMEVGL VLWVKEYDGVVVVVNFNSVGSWMIYEGEGSGLIREDPIGAGALYDYGRWLVVVTGWTL FVGVYIVIEIARGN" tRNA complement(14668..14736) /product="tRNA-Glu" gene 14741..15875 /gene="cytb" CDS 14741..15875 /gene="cytb" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:15875,aa:TERM) /transl_table=2 /product="cytochrome b" /protein_id="AAO88344.1" /db_xref="GI:29690461" /translation="MTPMRKINPLMKLINHSFIDLPTPSNISAWWNFGSLLGACLILQ ITTGLFLAMHYSPDASTAFSSIAHITRDVNYGWIIRYLHANGASMFFICLFLHIGRGL YYGSFLYSETWNIGIILLLATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDL VQWIWGGYSVDSPTLTRFFTFHFILPFIIAALAALHLLFLHETGSNNPLGITSHSDKI TFHPYYTIKDALGLLLFLLSLMTLTLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLF AYTILRSVPNKLGGVLALLLSILILAMIPILHMSKQQSMMFRPLSQSLYWLLAADLLI LTWIGGQPVSYPFTIIGQVASVLYFTTILILMPTISLIENKMLK" tRNA 15882..15947 /product="tRNA-Thr" tRNA complement(15949..16017) /product="tRNA-Pro" ORIGIN 1 gatcacaggt ctatcaccct attaaccact cacgggagct ctccatgcat ttggtatttt 61 cgtctggggg gtgtgcacgc gatagcattg cgagacgctg gagccggagc accctatgtc 121 gcagtatctg tctttgattc ctgcctcatc ctattattta tcgcacctac gttcaatatc 181 acaggcgaac atacttacta aagtgtgtta attaattaat gcttgtagga cataataata 241 acaattgaat gtctgcacag ccgctttcca cacagacatc ataacaaaaa atttccacca 301 aacccccccc ctccccccgc ttctggccac agcacttaaa cacatctctg ccaaacccca 361 aaaacaaaga accctaacac cagcctaacc agatttcaaa ttttatcttt tggcggtatg 421 cacttttaac agtcaccccc caactaacac attattttcc cctcccactc ccatactact 481 aatctcatca atacaacccc cacccatcct acccagcaca cacacaccgc tgctaacccc 541 ataccccgaa ccaaccaaac cccaaagaca ccccccacag tttatgtagc ttacctcctc 601 aaagcaatac actgaaaatg tttagacggg ctcacatcac cccataaaca aataggtttg 661 gtcctagcct ttctattagc tcttagtaag attacacatg caagcatccc cgttccagtg 721 agttcaccct ctaaatcacc acgatcaaaa gggacaagca tcaagcacgc agcaatgcag 781 ctcaaaacgc ttagcctagc cacaccccca cgggaaacag cagtgattag cctttagcaa 841 taaacgaaag tttaactaag ctatactaac cccagggttg gtcaatttcg tgccagccac 901 cgcggtcaca cgattaaccc aagtcaatag aagccggcgt aaagagtgtt ttagatcacc 961 ccctccccaa taaagctaaa actcacctga gttgtaaaaa actccagttg acacaaaata 1021 gactacgaaa gtggctttaa catatctgaa cacacaatag ctaagaccca aactgggatt 1081 agatacccca ctatgcttag ccctaaacct caacagttaa atcaacaaaa ctgctcgcca 1141 gaacactacg agccacagct taaaactcaa aggacctggc ggtgcttcat atccctctag 1201 aggagcctgt tctgtaatcg ataaaccccg atcaacctca ccacctcttg ctcagcctat 1261 ataccgccat cttcagcaaa ccctgatgaa ggctacaaag taagcgcaag tacccacgta 1321 aagacgttag gtcaaggtgt agcccatgag gtggcaagaa atgggctaca ttttctaccc 1381 cagaaaacta cgatagccct tatgaaactt aagggtcgaa ggtggattta gcagtaaact 1441 gagagtagag tgcttagttg aacagggccc tgaagcgcgt acacaccgcc cgtcaccctc 1501 ctcaagtata cttcaaagga catttaacta aaacccctac gcatttatat agaggagaca 1561 agtcgtaaca tggtaagtgt actggaaagt gcacttggac gaaccagagt gtagcttaac 1621 acaaagcacc caacttacac ttaggagatt tcaacttaac ttgaccgctc tgagctaaac 1681 ctagccccaa acccactcca ccttactacc agacaacctt agccaaacca tttacccaaa 1741 taaagtatag gcgatagaaa ttgaaacctg gcgcaataga tatagtaccg caagggaaag 1801 atgaaaaatt ataaccaagc ataatatagc aaggactaac ccctatacct tctgcataat 1861 gaattaacta gaaataactt tgcaaggaga gccaaagcta agacccccga aaccagacga 1921 gctacctaag aacagctaaa agagcacacc cgtctatgta gcaaaatagt gggaagattt 1981 ataggtagag gcgacaaacc taccgagcct ggtgatagct ggttgtccaa gatagaatct 2041 tagttcaact ttaaatttgc ccacagaacc ctctaaatcc ccttgtaaat ttaactgtta 2101 gtccaaagag gaacagctct ttggacacta ggaaaaaacc ttgtagagag agtaaaaaat 2161 ttaacaccca tagtaggcct aaaagcagcc accaattaag aaagcgttca agctcaacac 2221 ccactaccta aaaaatccca aacatataac tgaactcctc acacccaatt ggaccaatct 2281 atcaccctat agaagaacta atgttagtat aagtaacatg aaaacattct cctccgcata 2341 agcctgcgtc agattaaaac actgaactga caattaacag cccaatatct acaatcaacc 2401 aacaagtcat tattaccctc actgtcaacc caacacaggc atgctcataa ggaaaggtta 2461 aaaaaagtaa aaggaactcg gcaaatctta ccccgcctgt ttaccaaaaa catcacctct 2521 agcatcacca gtattagagg caccgcctgc ccagtgacac atgtttaacg gccgcggtac 2581 cctaaccgtg caaaggtagc ataatcactt gttccttaaa tagggacctg tatgaatggc 2641 tccacgaggg ttcagctgtc tcttactttt aaccagtgaa attgacctgc ccgtgaagag 2701 gcgggcatga cacagcaaga cgagaagacc ctatggagct ttaatttatt aatgcaaaca 2761 gtacctaaca aacccacagg tcctaaacta ccaaacctgc attaaaaatt tcggttgggg 2821 cgacctcgga gcagaaccca acctccgagc agtacatgct aagacttcac cagtcaaagc 2881 gaactactat actcaattga tccaataact tgaccaacgg aacaagttac cctagggata 2941 acagcgcaat cctattctag agtccatatc aacaataggg tttacgacct cgatgttgga 3001 tcaggacatc ccgatggtgc agccgctatt aaaggttcgt ttgttcaacg attaaagtcc 3061 tacgtgatct gagttcagac cggagtaatc caggtcggtt tctatctact tcaaattcct 3121 ccctgtacga aaggacaaga gaaataaggc ctacttcaca aagcgccttc ccccgtaaat 3181 gatatcatct caacttagta ttatacccac acccacccaa gaacagggtt tgttaagatg 3241 gcagagcccg gtaatcgcat aaaacttaaa actttacagt cagaggttca attcctcttc 3301 ttaacaacat acccatggcc aacctcctac tcctcattgt acccattcta atcgcaatgg 3361 cattcctaat gcttaccgaa cgaaaaattc taggctatat acaactacgc aaaggcccca 3421 acgttgtagg cccctacggg ctactacaac ccttcgctga cgccataaaa ctcttcacca 3481 aagagcccct aaaacccgcc acatctacca tcaccctcta catcaccgcc ccgaccttag 3541 ctctcaccgt cgctcttcta ctatgaaccc ccctccccat acccaacccc ctggtcaacc 3601 tcaacctagg cctcctattt attctagcca cctctagcct agccgtttac tcaatcctct 3661 gatcagggtg agcatcaaac tcaaactacg ccctgatcgg cgcactgcga gcagtagccc 3721 aaacaatctc atatgaagtc accctagcca tcattctact atcaacatta ctaataagtg 3781 gctcctttaa cctctccacc cttatcacaa cacaagaaca cctctgatta ctcctgccat 3841 catgaccctt ggccataata tgatttatct ccacactagc agagaccaac cgaaccccct 3901 tcgaccttgc cgaaggggag tccgaactag tctcaggctt caacatcgaa tacgccgcag 3961 gccccttcgc cctattcttc atagccgaat acacaaacat tattataata aacaccctca 4021 ccactacaat cttcctagga acaacatatg acgcactctc ccctgaactc tacacaacat 4081 attttgtcac caagacccta cttctaacct ccctgttctt atgggttcga acagcatacc 4141 cccgattccg ctacgaccaa ctcatacacc tcctatgaaa aaacttccta ccactcaccc 4201 tagcattact tatatgatat gtctccatac ccattacaat ctccagcatt ccccctcaaa 4261 cctaagaaat atgtctgata aaagagttac tttgatagag taaataatag gagcttaaac 4321 ccccttattt ctaggactat gagaatcgaa cccatccctg agaatccaaa attctccgtg 4381 ccacctatca caccccatcc taaagtaagg tcagctaaat aagctatcgg gcccataccc 4441 cgaaaatgtt ggttataccc ttcccgtact aattaatccc ctggcccaac ccgtcatcta 4501 ctctaccatc tttgcaggca cactcatcac agcgctaagc tcgcactgat tttttacctg 4561 agtaggccta gaaataaaca tgctagcttt tattccagtt ctaaccaaaa aaataaaccc 4621 tcgttccaca gaagctgcca tcaagtattt cctcacgcaa gcaaccgcat ccataatcct 4681 tctaatagct atcctcttca acaatatact ctccggacaa tgaaccataa ccaatactac 4741 caatcaatac tcatcattaa taatcataat ggctatagca ataaaactag gaatagcccc 4801 ctttcacttc tgagtcccag aagttaccca aggcacccct ctgacatccg gcctgcttct 4861 tctcacatga caaaaactag cccccatctc aatcatatac caaatctctc cctcactaaa 4921 cgtaagcctt ctcctcactc tctcaatctt atccatcata gcaggcagtt gaggtggact 4981 aaaccaaacc cagctacgca aaatcttagc atactcctca attacccaca taggatgaat 5041 aatagcagtt ctaccgtaca accctaacat aaccattctt aatttaacta tttatattat 5101 cctaactact accgcattcc tactactcaa cttaaactcc agcaccacga ccctactact 5161 atctcgcacc tgaaacaagc taacatgact aacaccctta attccatcca ccctcctctc 5221 cctaggaggc ctgcccccgc taaccggctt tttgcccaaa tgggccatta tcgaagaatt 5281 cacaaaaaac aatagcctca tcatccccac catcatagcc accatcaccc tccttaacct 5341 ctacttctac ctacgcctaa tctactccac ctcaatcaca ctactcccca tatctaacaa 5401 cgtaaaaata aaatgacagt ttgaacatac aaaacccacc ccattcctcc ccacactcat 5461 cgcccttacc acgctactcc tacctatctc cccttttata ctaataatct tatagaaatt 5521 taggttaaat acagaccaag agccttcaaa gccctcagta agttgcaata cttaatttct 5581 gtaacagcta aggactgcaa aaccccactc tgcatcaact gaacgcaaat cagccacttt 5641 aattaagcta agcccttact agaccaatgg gacttaaacc cacaaacact tagttaacag 5701 ctaagcaccc taatcaactg gcttcaatct acttctcccg ccgccgggaa aaaaggcggg 5761 agaagccccg gcaggtttga agctgcttct tcgaatttgc aattcaatat gaaaatcacc 5821 tcggagctgg taaaaagagg cctaacccct gtctttagat ttacagtcca atgcttcact 5881 cagccatttt acctcacccc cactgatgtt cgccgaccgt tgactattct ctacaaacca 5941 caaagacatt ggaacactat acctattatt cggcgcatga gctggagtcc taggcacagc 6001 tctaagcctc cttattcgag ccgagctggg ccagccaggc aaccttctag gtaacgacca 6061 catctacaac gttatcgtca cagcccatgc atttgtaata atcttcttca tagtaatacc 6121 catcataatc ggaggctttg gcaactgact agttccccta ataatcggtg cccccgatat 6181 ggcgtttccc cgcataaaca acataagctt ctgactctta cctccctctc tcctactcct 6241 gctcgcatct gctatagtgg aggccggagc aggaacaggt tgaacagtct accctccctt 6301 agcagggaac tactcccacc ctggagcctc cgtagaccta accatcttct ccttacacct 6361 agcaggtgtc tcctctatct taggggccat caatttcatc acaacaatta tcaatataaa 6421 accccctgcc ataacccaat accaaacgcc cctcttcgtc tgatccgtcc taattacagc 6481 agtcctactt ctcctatctc tcccagtcct agctgctggc atcactatac tactaacaga 6541 ccgcaacctc aacaccacct tcttcgaccc cgccggagga ggagacccca ttctatacca 6601 acacctattc tgatttttcg gtcaccctga agtttatatt cttatcctac caggcttcgg 6661 aataatctcc catattgtaa cttactactc cggaaaaaaa gaaccatttg gatacatagg 6721 tatggtctga gctatgatat caattggctt cctagggttt atcgtgtgag cacaccatat 6781 atttacagta ggaatagacg tagacacacg agcatatttc acctccgcta ccataatcat 6841 cgctatcccc accggcgtca aagtatttag ctgactcgcc acactccacg gaagcaatat 6901 gaaatgatct gctgcagtgc tctgagccct aggattcatc tttcttttca ccgtaggtgg 6961 cctgactggc attgtattag caaactcatc actagacatc gtactacacg acacgtacta 7021 cgttgtagct cacttccact atgtcctatc aataggagct gtatttgcca tcataggagg 7081 cttcattcac tgatttcccc tattctcagg ctacacccta gaccaaacct acgccaaaat 7141 ccatttcact atcatattca tcggcgtaaa tctaactttc ttcccacaac actttctcgg 7201 cctatccgga atgccccgac gttactcgga ctaccccgat gcatacacca catgaaacat 7261 cctatcatct gtaggctcat tcatttctct aacagcagta atattaataa ttttcatgat 7321 ttgagaagcc ttcgcttcga agcgaaaagt cctaatagta gaagaaccct ccataaacct 7381 ggagtgacta tatggatgcc ccccacccta ccacacattc gaagaacccg tatacataaa 7441 atctagacaa aaaaggaagg aatcgaaccc cccaaagctg gtttcaagcc aaccccatgg 7501 cctccatgac tttttcaaaa aggtattaga aaaaccattt cataactttg tcaaagttaa 7561 attataggct aaatcctata tatcttaatg gcacatgcag cgcaagtagg tctacaagac 7621 gctacttccc ctatcataga agagcttatc acctttcatg atcacgccct cataatcatt 7681 ttccttatct gcttcctagt cctgtatgcc cttttcctaa cactcacaac aaaactaact 7741 aatactaaca tctcagacgc tcaggaaata gaaaccgtct gaactatcct gcccgccatc 7801 atcctagtcc tcatcgccct cccatcccta cgcatccttt acataacaga cgaggtcaac 7861 gatccctccc ttaccatcaa atcaattggc caccaatggt actgaaccta cgagtacacc 7921 gactacggcg gactaatctt caactcctac atacttcccc cattattcct agaaccaggc 7981 gacctgcgac tccttgacgt tgacaatcga gtagtactcc cgattgaagc ccccattcgt 8041 ataataatta catcacaaga cgtcttgcac tcatgagctg tccccacatt aggcttaaaa 8101 acagatgcaa ttcccggacg tctaaaccaa accactttca ccgctacacg accgggggta 8161 tactacggtc aatgctctga aatctgtgga gcaaaccaca gtttcatgcc catcgtccta 8221 gaattaattc ccctaaaaat ctttgaaata gggcccgtat ttaccctata gctaccccct 8281 ctagagccca ctgtaaagct aacttagcat taacctttta agttaaagat taagagaacc 8341 aacacctctt tacagtgaaa tgccccaact aaatactacc gtatggccca ccataattac 8401 ccccatactc cttacactat tcctcatcac ccaactaaaa atattaaaca caaactacca 8461 cctacctccc tcaccaaagc ccataaaaat aaaaaattat aacaaaccct gagaaccaaa 8521 atgaacgaaa atctgttcgc ttcattcatt gcccccacaa tcctaggcct acccgccgca 8581 gtactgatca ttctatttcc ccctctattg atccccacct ccaaatatct catcaacaac 8641 cgactaatca ccacccaaca atgactaatc aaactaacct caaaacaaat gataaccata 8701 cacaacacta aaggacgaac ctgatctctt atactagtat ccttaatcat ttttattgcc 8761 acaactaacc tcctcggact cctgcctcac tcatttacac caaccaccca actatctata 8821 aacctagcca tggccatccc cttatgagcg ggcgcagtga ttataggcct tcgctctaag 8881 attaaaaatg ccctagccca cttcttacca caaggcacac ctacacccct tatccccata 8941 ctagttatta tcgaaaccat cagcctactc attcaaccaa tagccctggc cgtacgccta 9001 accgctaaca ttactgcagg ccacctactc atgcacctaa ttggaagcgc caccctagca 9061 atatcaacca ttaaccttcc ctctacactt atcatcttca caattctaat tctactgact 9121 atcctagaaa tcgctgtcgc cttaatccaa gcctacgttt tcacacttct agtaagcctc 9181 tacctgcacg acaacacata atgacccacc aatcacatgc ctatcatata gtaaaaccca 9241 gcccatgacc cctaacaggg gccctctcag ccctcctaat gacctccggc ctagccatgt 9301 gatttcactt ccactccata acgctcctca tactaggcct actaaccaac acactaacca 9361 tataccaatg atggcgcgat gtaacacgag aaagcacata ccaaggccac cacacaccac 9421 ctgtccaaaa aggccttcga tacgggataa tcctatttat tacctcagaa gtttttttct 9481 tcgcaggatt tttctgagcc ttttaccact ccagcctagc ccctaccccc caattaggag 9541 ggcactggcc cccaacaggc atcaccccgc taaatcccct agaagtccca ctcctaaaca 9601 catccgtatt actcgcatca ggagtatcaa tcacctgagc tcaccatagt ctaatagaaa 9661 acaaccgaaa ccaaacaatt caagcactgc ttattacaat tttactgggt ctctatttta 9721 ccctcctaca agcctcagag tacttcgagt ctcccttcac catttccgac ggcatctacg 9781 gctcaacatt ttttgtagcc acaggcttcc acggacttca cgtcattatt ggctcaactt 9841 tcctcactat ctgcttcatc cgccaactaa tatttcactt tacatccaaa catcactttg 9901 gcttcgaagc cgccgcctga tactggcatt ttgtagatgt ggtctgacta tttctgtatg 9961 tctccatcta ttgatgaggg tcttactctt ttagtataaa tagtaccgtt aacttccaat 10021 taactagttt tgacaacatt caaaaaagag taataaactt cgccttaatt ttaataatca 10081 acaccctcct agccttacta ctaataatta ttacattttg actaccacaa ctcaacggct 10141 acatagaaaa atccacccct tacgagtgcg gcttcgaccc tatatccccc gcccgcgtcc 10201 ctttctccat aaaattcttc ttagtagcta ttaccttctt attatttgat ctagaaattg 10261 ccctcctttt acccctacca tgagccctac aaacaactaa cctgccacta atagttatgt 10321 catccctctt attaatcatc atcctagccc taagtctggc ctatgagtga ctacaaaaag 10381 gattagactg aaccgaattg gtatatagtt taaacaaaac gaatgatttc gactcattaa 10441 attatgataa tcatatttac caaatgcccc tcatttacat aaatattata ctagcattta 10501 ccatctcact tctaggaata ctagtatatc gctcacacct catatcctcc ctactatgcc 10561 tagaaggaat aatactatcg ctgttcatta tagctactct cataaccctc aacacccact 10621 ccctcttagc caatattgtg cctattgcca tactagtctt tgccgcctgc gaagcagcgg 10681 tgggcctagc cctactagtc tcaatctcca acacatatgg cctagactac gtacataacc 10741 taaacctact ccaatgctaa aactaatcgt cccaacaatt atattactac cactgacatg 10801 actttccaaa aaacacataa tttgaatcaa cacaaccacc cacagcctaa ttattagcat 10861 catccctcta ctatttttta accaaatcaa caacaaccta tttagctgtt ccccaacctt 10921 ttcctccgac cccctaacaa cccccctcct aatactaact acctgactcc tacccctcac 10981 aatcatggca agccaacgcc acttatccag tgaaccacta tcacgaaaaa aactctacct 11041 ctctatacta atctccctac aaatctcctt aattataaca ttcacagcca cagaactaat 11101 catattttat atcttcttcg aaaccacact tatccccacc ttggctatca tcacccgatg 11161 aggcaaccag tcagaacgcc tgaacgcagg cacatacttc ctattctaca ccctagtagg 11221 ctcccttccc ctactcatcg cactaattta cactcacaac accctaggct cactaaacat 11281 tctactactc actctcactg cccaagaact atcaaactcc tgagccaaca acttaatatg 11341 actagcttac acaatagctt ttatagtaaa gatacctctt tacggactcc acttatgact 11401 ccctaaagcc catgtcgaag cccccatcgc tgggtcaata gtacttgccg cagtactctt 11461 aaaactaggc ggctatggta taatacgcct cacactcatt ctcaaccccc tgacaaaaca 11521 catagcctac cccttccttg tactatccct atgaggcata attataacaa gctccatctg 11581 cctacgacaa acagacctaa aatcgctcat tgcatactct tcaatcagcc acatagccct 11641 cgtagtaaca gccattctca tccaaacccc ctgaagcttc accggcgcag tcattctcat 11701 aatcgcccac ggacttacat cctcattact attctgccta gcaaactcaa actacgaacg 11761 cactcacagt cgcatcataa tcctctctca aggacttcaa actctactcc cactaatagc 11821 tttttgatga cttctagcaa gcctcgctaa cctcgcctta ccccccacta ttaacctact 11881 gggagaactc tctgtgctag taaccacgtt ctcctgatca aatatcactc tcctacttac 11941 aggactcaac atactagtca cagccctata ctccctctac atatttacca caacacaatg 12001 gggctcactc acccaccaca ttaacaacat aaaaccctca ttcacacgag aaaacaccct 12061 catgttcata cacctatccc ccattctcct cctatccctc aaccccgaca tcattaccgg 12121 gttttcctct tgtaaatata gtttaaccaa aacatcagat tgtgaatctg acaacagagg 12181 cttacgaccc cttatttacc gagaaagctc acaagaactg ctaactcatg cccccatgtc 12241 taacaacatg gctttctcaa cttttaaagg ataacagcta tccattggtc ttaggcccca 12301 aaaattttgg tgcaactcca aataaaagta ataaccatgc acactactat aaccacccta 12361 accctgactt ccctaattcc ccccatcctt accaccctcg ttaaccctaa caaaaaaaac 12421 tcataccccc attatgtaaa atccattgtc gcatccacct ttattatcag tctcttcccc 12481 acaacaatat tcatgtgcct agaccaagaa gttattatct cgaactgaca ctgagccaca 12541 acccaaacaa cccagctctc cctaagcttc aaactagact acttctccat aatattcatc 12601 cctgtagcat tgttcgttac atggtccatc atagaattct cactgtgata tataaactca 12661 gacccaaaca ttaatcagtt cttcaaatat ctactcatct tcctaattac catactaatc 12721 ttagttaccg ccaacaacct attccaactg ttcatcggct gagagggcgt aggaattata 12781 tccttcttgc tcatcagttg atgatacgcc cgagcagatg ccaacacagc agccattcaa 12841 gcaatcctat acaaccgtat cggcgatatc ggtttcatcc tcgccttagc atgatttatc 12901 ctacactcca actcatgaga cccacaacaa atagcccttc taaacgctaa tccaagcctc 12961 accccactac taggcctcct cctagcagca gcaggcaaat cagcccaatt aggtctccac 13021 ccctgactcc cctcagccat agaaggcccc accccagtct cagccctact ccactcaagc 13081 actatagttg tagcaggaat cttcttactc atccgcttcc accccctagc agaaaatagc 13141 ccactaatcc aaactctaac actatgctta ggcgctatca ccactctgtt cgcagcagtc 13201 tgcgccctta cacaaaatga catcaaaaaa atcgtagcct tctccacttc aagtcaacta 13261 ggactcataa tagttacaat cggcatcaac caaccacacc tagcattcct gcacatctgt 13321 acccacgcct tcttcaaagc catactattt atgtgctccg ggtccatcat ccacaacctt 13381 aacaatgaac aagatattcg aaaaatagga ggactactca aaaccatacc tctcacttca 13441 acctccctca ccattggcag cctagcatta gcaggaatac ctttcctcac aggtttctac 13501 tccaaagacc acatcatcga aaccgcaaac atatcataca caaacgcctg agccctatct 13561 attactctca tcgctacctc cctaacaagc gcctatagca ctcgaataat tcttctcacc 13621 ctaacaggtc aacctcgctt ccccaccctt actaacatta acgaaaataa ccccacccta 13681 ctaaacccca ttaaacgcct ggcagccgga agcctattcg caggatttct cattactaac 13741 aacatttccc ccgcatcccc cttccaaaca acaatccccc tctacctaaa actcacagcc 13801 ctcgctgtca ctttcctagg acttctaaca gccctagacc tcaactacct aaccaacaaa 13861 cttaaaataa aatccccact atgc