LOCUS AY195745 16568 bp DNA circular PRI 10-JUN-2004 DEFINITION Homo sapiens haplotype E12T mitochondrion, complete genome. ACCESSION AY195745 VERSION AY195745.2 GI:48596135 KEYWORDS . SOURCE mitochondrion Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 16568) AUTHORS Mishmar,D., Ruiz-Pesini,E., Golik,P., Macaulay,V., Clark,A.G., Hosseini,S., Brandon,M., Easley,K., Chen,E., Brown,M.D., Sukernik,R.I., Olckers,A. and Wallace,D.C. TITLE Natural selection shaped regional mtDNA variation in humans JOURNAL Proc. Natl. Acad. Sci. U.S.A. 100 (1), 171-176 (2003) MEDLINE 22406325 PUBMED 12509511 REFERENCE 2 (bases 1 to 16568) AUTHORS Mishmar,D., Ruiz-Pesini,E., Golik,P., Macaulay,V., Clark,A.G., Hosseini,S., Brandon,M., Easley,K., Chen,E., Brown,M.D., Sukernik,R.I., Olckers,A. and Wallace,D.C. TITLE Direct Submission JOURNAL Submitted (11-DEC-2002) MAMMAG, University of California, Irvine, 2nd Floor Hewitt Hall, Irvine, California 92697-3940, USA REFERENCE 3 (bases 1 to 16568) AUTHORS Mishmar,D., Ruiz-Pesini,E., Golik,P., Macaulay,V., Clark,A.G., Hosseini,S., Brandon,M., Easley,K., Chen,E., Brown,M.D., Sukernik,R.I., Olckers,A. and Wallace,D.C. TITLE Direct Submission JOURNAL Submitted (10-JUN-2004) MAMMAG, University of California, Irvine, 2nd Floor Hewitt Hall, Irvine, California 92697-3940, USA REMARK Sequence update by submitter COMMENT On Jun 10, 2004 this sequence version replaced gi:29690392. FEATURES Location/Qualifiers source 1..16568 /organism="Homo sapiens" /organelle="mitochondrion" /mol_type="genomic DNA" /isolation_source="T haplogroup" /db_xref="taxon:9606" /haplotype="E12T" D-loop complement(join(16103..16568,1..191)) tRNA 577..647 /product="tRNA-Phe" rRNA 648..1601 /product="12S ribosomal RNA" tRNA 1602..1670 /product="tRNA-Val" rRNA 1671..3228 /product="16S ribosomal RNA" tRNA 3229..3303 /product="tRNA-Leu" gene 3306..4262 /gene="ND1" CDS 3306..4262 /gene="ND1" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 1" /protein_id="AAO88280.1" /db_xref="GI:29690393" /translation="MPMANLLLLIVPILIAMAFLMLTERKILGYMQLRKGPNVVGPYG LLQPFADAMKLFTKEPLKPATSTITLYITAPTLALTIALLLWTPLPMPNPLVNLNLGL LFILATSSLAVYSILWSGWASNSNYALIGALRAVAQTISYEVTLAIILLSTLLMSGSF NLSTLITTQEHLWLLLPSWPLAMMWFISTLAETNRTPFDLAEGESELVSGFNIEYAAG PFALFFMAEYTNIIMMNTLTTTIFLGTTYDALSPELYTTYFVTKTLLLTSLFLWIRTA YPRFRYDQLMHLLWKNFLPLTLALLMWHVSMPITISSIPPQT" tRNA 4262..4330 /product="tRNA-Ile" tRNA complement(4328..4399) /product="tRNA-Gln" tRNA 4401..4468 /product="tRNA-Met" gene 4469..5512 /gene="ND2" CDS 4469..5512 /gene="ND2" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 2" /protein_id="AAO88281.1" /db_xref="GI:29690394" /translation="MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVL TKKMNPRSTEAAIKYFLTQATASMILLMAILFNNMLSGQWTMTNTTNQYSSLMIMMAM AMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPSLDVSLLLTLSIL SIMAGSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLL LNLNSSTTTLLLSRTWNKLTWLTPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSL IIPTIMATITLLNLYFYLRLIYSTSITLLPMSNNVKMKWQFEHTKPTPFLPTLIALTT LLLPISPFMLMIL" tRNA 5511..5578 /product="tRNA-Trp" tRNA complement(5586..5654) /product="tRNA-Ala" tRNA complement(5656..5728) /product="tRNA-Asn" tRNA complement(5760..5825) /product="tRNA-Cys" tRNA complement(5825..5890) /product="tRNA-Tyr" gene 5903..7444 /gene="COX1" CDS 5903..7444 /gene="COX1" /codon_start=1 /transl_table=2 /product="cytochrome oxidase subunit I" /protein_id="AAO88282.1" /db_xref="GI:29690395" /translation="MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQP GNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSF WLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILG AINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTT FFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWA MMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKW SAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGG FIHWFPLFSGYTLDQTYAKIHFTIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTW NILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEEP VYMKS" tRNA complement(7444..7515) /product="tRNA-Ser" tRNA 7517..7584 /product="tRNA-Asp" gene 7585..8268 /gene="COX2" CDS 7585..8268 /gene="COX2" /codon_start=1 /transl_table=2 /product="cytochrome oxidase subunit II" /protein_id="AAO88283.1" /db_xref="GI:29690396" /translation="MAHAAQVGLQDATSPIMEELITFHDHALMIIFLICFLVLYALFL TLTTKLTNTNISDAQEMETVWTILPAIILVLIALPSLRILYMTDEVNDPSLTIKSIGH QWYWTYEYTDYGGLIFNSYMLPPLFLEPGDLRLLDVDNRVVLPIEAPIRMMITSQDVL HSWAVPTLGLKTDAIPGRLNQTTFTATRPGVYYGQCSEICGANHSFMPIVLELIPLKI FEMGPVFTL" tRNA 8294..8363 /product="tRNA-Lys" gene 8365..8571 /gene="ATP8" CDS 8365..8571 /gene="ATP8" /codon_start=1 /transl_table=2 /product="ATP synthase F0 subunit 8" /protein_id="AAO88284.1" /db_xref="GI:29690397" /translation="MPQLNTTVWPTMITPMLLTLFLITQLKMLNTNYHLPPSPKPMKM KNYNKPWEPKWTKICSLHSLPPQS" gene 8526..9206 /gene="ATP6" CDS 8526..9206 /gene="ATP6" /codon_start=1 /transl_table=2 /product="ATP synthase F0 subunit 6" /protein_id="AAO88285.1" /db_xref="GI:29690398" /translation="MNENLFASFIAPTILGLPAAVLIILFPPLLIPTSKYLINNRLIT TQQWLIKLTSKQMMTMHNTKGRTWSLMLVSLIIFIATTNLLGLLPHSFTPTTQLSMNL AMAIPLWAGAVIMGFRSKIKNALAHFLPQGTPTPLIPMLVIIETISLLIQPMALAVRL TANITAGHLLMHLIGSATLAMSTINLPSTLIIFTILILLTILEIAVALIQAYVFTLLV SLYLHDNT" gene 9206..9986 /gene="COX3" CDS 9206..9986 /gene="COX3" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:9986,aa:TERM) /transl_table=2 /product="cytochrome oxidase subunit III" /protein_id="AAO88286.1" /db_xref="GI:29690399" /translation="MTHQSHAYHMVKPSPWPLTGALSALLMTSGLAMWFHFHSMTLLM LGLLTNTLTMYQWWRDVTRESTYQGHHTPPVQKGLRYGMILFITSEVFFFAGFFWAFY HSSLAPTPQLGGHWPPTGITPLNPLEVPLLNTSVLLASGVSITWAHHSLMENNRNQMI QALLITILLGLYFTLLQASEYFESPFTISDGIYGSTFFVATGFHGLHVIIGSTFLTIC FIRQLMFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIYWWG" tRNA 9990..10057 /product="tRNA-Gly" gene 10058..10403 /gene="ND3" CDS 10058..10403 /gene="ND3" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:10403,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 3" /protein_id="AAO88287.1" /db_xref="GI:29690400" /translation="MNFALILMINTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPM SPARVPFSMKFFLVAITFLLFDLEIALLLPLPWALQTTNLPLMVMSSLLLIIILALSL AYEWLQKGLDWTE" tRNA 10404..10468 /product="tRNA-Arg" gene 10469..10765 /gene="ND4L" CDS 10469..10765 /gene="ND4L" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 4L" /protein_id="AAO88288.1" /db_xref="GI:29690401" /translation="MPLIYMNIMLAFTISLLGMLVYRSHLMSSLLCLEGMMLSLFIMA TLMTLNTHSLLANIVPIAMLVFAACEAAVGLALLVSISNTYGLDYVHNLNLLQC" gene 10759..12136 /gene="ND4" CDS 10759..12136 /gene="ND4" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:12136,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 4" /protein_id="AAO88289.1" /db_xref="GI:29690402" /translation="MLKLIVPTIMLLPLTWLSKKHMIWINTTTHSLIISIIPLLFFNQ INNNLFSCSPTFSSDPLTTPLLMLTTWLLPLTIMASQRHLSSEPLSRKKLYLSMLISL QISLIMTFTATELIMFYIFFETTLIPTLAIITRWGNQPERLNAGTYFLFYTLVGSLPL LIALIYTHNTLGSLNILLLTLTAQELSNSWANNLMWLAYTMAFMVKMPLYGLHLWLPK AHVEAPIAGSMVLAAVLLKLGGYGMMRLTLILNPLTKHMAYPFLVLSLWGMIMTSSIC LRQTDLKSLIAYSSISHMALVVTAILIQTPWSFTGAVILMIAHGLTSSLLFCLANSNY ERTHSRIMILSQGLQTLLPLMAFWWLLASLANLALPPTINLLGELSVLVTTFSWSNIT LLLTGLNMLVTALYSLYMFTTTQWGSLTHHINNMKPSFTRENTLMFMHLSPILLLSLN PDIITGFSS" tRNA 12137..12205 /product="tRNA-His" tRNA 12206..12264 /product="tRNA-Ser" tRNA 12265..12335 /product="tRNA-Leu" gene 12336..14147 /gene="ND5" CDS 12336..14147 /gene="ND5" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 5" /protein_id="AAO88290.1" /db_xref="GI:29690403" /translation="MTMHTTMTTLTLTSLIPPILTTLVNPNKKNSYPHYVKSIVASTF IISLFPTTMFMCLDQEVIISNWHWATTQTTQLSLSFKLDYFSMMFIPVALFVTWSIME FSLWYMNSDPNINQFFKYLLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLISWWYA RADANTAAIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLNANPSLTPLLGLLL AAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFHPLAENSPLIQTL TLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAF FKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSK DHIIETANMSYTNAWALSITLIATSLTSAYSTRMILLTLTGQPRFPTLTNINENNPTL LNPIKRLAAGSLFAGFLITNNISPASPFQTTIPLYLKLTALAVTFLGLLTALDLNYLT NKLKMKSPLCTFYFSNMLGFYPSITHRTIPYLGLLTSQNLPLLLLDLTWLEKLLPKTI SQHQISTSIITSTQKGMIKLYFLSFFFPLILTLLLIT" gene complement(14148..14672) /gene="ND6" CDS complement(14148..14672) /gene="ND6" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 6" /protein_id="AAO88291.1" /db_xref="GI:29690404" /translation="MMYALFLLSVGLVMGFVGFSSKPSPIYGGLVLIVSGVVGCVIIL NFGGGYMGLMVFLIYLGGMMVVFGYTTAMAIEEYPEAWGSGVEVLVSVLVGLAMEVGL VLWVKEYDGVVVVVNFNSVGSWMIYEGEGSGLIREDPIGAGALYDYGRWLVVVTGWTL FVGVYIVIEIARGN" tRNA complement(14673..14741) /product="tRNA-Glu" gene 14746..15880 /gene="cytb" CDS 14746..15880 /gene="cytb" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:15880,aa:TERM) /transl_table=2 /product="cytochrome b" /protein_id="AAO88292.1" /db_xref="GI:29690405" /translation="MTPMRKINPLMKLINHSFIDLPTPSNISAWWNFGSLLGACLILQ ITTGLFLAMHYSPDASTAFSSIAHITRDVNYGWIIRYLHANGASMFFICLFLHIGRGL YYGSFLYSETWNIGIILLLATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDL VQWIWGGYSVDSPTLTRFFTFHFILPFIIAALAALHLLFLHETGSNNPLGITSHSDKI TFHPYYTIKDALGLLLFILSLMTLTLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLF AYTILRSVPNKLGGVLALLLSILILAMIPILHMSKQQSMMFRPLSQSLYWLLAADLLI LTWIGGQPVSYPFTIIGQVASVLYFTTILILMPTISLIENKMLK" tRNA 15887..15952 /product="tRNA-Thr" tRNA complement(15954..16022) /product="tRNA-Pro" ORIGIN 1 gatcacaggt ctatcaccct attaaccact cacgggagct ctccatgcat ttggtatttt 61 cgtctggggg gtgtgcacgc gatagcattg cgagacgctg gagccggagc accctatgtc 121 gcagtatctg tctttgattc ctgcctcatc ccattattta tcgcacctac gttcaatatt 181 acaggcgaac atacctacta aagtgtgtta attaattaat gcttgtagga cataataata 241 acaattgaat gtctgcacag ccgctttcca cacagacatc ataacaaaaa atttccacca 301 aaccccccct cccccgcttc tggccacagc acttaaacac atctctgcca aaccccaaaa 361 acaaagaacc ctaacaccag cctaaccaga tttcaaattt tatcttttgg cggtatgcac 421 ttttaacagt caccccccaa ctaacacatt attttcccct cccactccca tactactaat 481 ctcatcaata caacccccgc ccatcctacc cagcacacac acaccgctgc taaccccata 541 ccccgaacca accaaacccc aaagacaccc cccacagttt atgtagctta cctcctcaaa 601 gcaatacact gaaaatgttt agacgggctc acatcacccc ataaacaaat aggtttggtc 661 ctagcctttc tattagctct tagtaagatt acacatgcaa gcatccccat tccagtgagt 721 tcaccctcta aatcaccacg atcaaaaggg acaagcatca agcacgcagc aatgcagctc 781 aaaacgctta gcctagccac acccccacgg gaaacagcag tgattaacct ttagcaataa 841 acgaaagttt aactaagcta tactaacccc agggttggtc aatttcgtgc cagccaccgc 901 ggtcacacga ttaacccaag tcaatagaaa ccggcgtaaa gagtgtttta gatcaccccc 961 tccccaataa agctaaaact cacctgagtt gtaaaaaact ccagttgaca caaaatagac 1021 tacgaaagtg gctttaacat atctgaacac acaatagcta agacccaaac tgggattaga 1081 taccccacta tgcttagccc taaacctcaa cagttaaatc aacaaaactg ctcgccagaa 1141 cactacgagc cacagcttaa aactcaaagg acctggcggt gcttcatatc cctctagagg 1201 agcctgttct gtaatcgata aaccccgatc aacctcacca cctcttgctc agcctatata 1261 ccgccatctt cagcaaaccc tgatgaaggc tacaaagtaa gcgcaagtac ccacgtaaag 1321 acgttaggtc aaggtgtagc ccatgaggtg gcaagaaatg ggctacattt tctaccccag 1381 aaaactacga tagcccttat gaaacttaag ggtcgaaggt ggatttagca gtaaactgag 1441 agtagagtgc ttagttgaac agggccctga agcgcgtaca caccgcccgt caccctcctc 1501 aagtatactt caaaggacat ttaactaaaa cccctacgca tttatataga ggagacaagt 1561 cgtaacatgg taagtgtact ggaaagtgca cttggacgaa ccagagtgta gcttaacaca 1621 aagcacccaa cttacactta ggagatttca acttaacttg accgctctga gctaaaccta 1681 gccccaaacc cactccacct tactaccaga caaccttagc caaaccattt acccaaataa 1741 agtataggcg atagaaattg aaacctggcg caatagatat agtaccgcaa gggaaagatg 1801 aaaaattata accaagcata atatagcaag gactaacccc tataccttct gcataatgaa 1861 ttaactagaa ataactttgc aaggagaacc aaagctaaga cccccgaaac cagacgagct 1921 acctaagaac agctaaaaga gcacacccgt ctatgtagca aaatagtggg aagatttata 1981 ggtagaggcg acaaacctac cgagcctggt gatagctggt tgtccaagat agaatcttag 2041 ttcaacttta aatttgccca cagaaccctc taaatcccct tgtaaattta actgttagtc 2101 caaagaggaa cagctctttg gacactagga aaaaaccttg tagagagagt aaaaaattta 2161 acacccatag taggcctaaa agcagccacc aattaagaaa gcgttcaagc tcaacaccca 2221 ctacctaaaa aatcccaaac atataactga actcctcaca cccaattgga ccaatctatc 2281 accctataga agaactaatg ttagtataag taacatgaaa acattctcct ccgcataagc 2341 ctgcgtcaga ttaaaacact gaactgacaa ttaacagccc aatatctaca atcaaccaac 2401 aagtcattat taccctcact gtcaacccaa cacaggcatg ctcataagga aaggttaaaa 2461 aaagtaaaag gaactcggca aatcttaccc cgcctgttta ccaaaaacat cacctctagc 2521 atcaccagta ttagaggcac cgcctgccca gtgacacatg tttaacggcc gcggtaccct 2581 aaccgtgcaa aggtagcata atcacttgtt ccttaaatag ggacctgtat gaatggctcc 2641 acgagggttc agctgtctct tacttttaac cagtgaaatt gacctgcccg tgaagaggcg 2701 ggcatgacac agcaagacga gaagacccta tggagcttta atttattaat gcaaacagta 2761 cctaacaaac ccacaggtcc taaactacca aacctgcatt aaaaatttcg gttggggcga 2821 cctcggagca gaacccaacc tccgagcagt acatgctaag acttcaccag tcaaagcgaa 2881 ctactatact caattgatcc aataacttga ccaacggaac aagttaccct agggataaca 2941 gcgcaatcct attctagagt ccatatcaac aatagggttt acgacctcga tgttggatca 3001 ggacatcccg atggtgcagc cgctattaaa ggttcgtttg ttcaacgatt aaagtcctac 3061 gtgatctgag ttcagaccgg agtaatccag gtcggtttct atctacttca aattcctccc 3121 tgtacgaaag gacaagagaa ataaggccta cttcacaaag cgccttcccc cgtaaatgat 3181 atcatctcaa cttagtatta tacccacacc cacccaagaa cagggtttgt taagatggca 3241 gagcccggta atcgcataaa acttaaaact ttacagtcag aggttcaatt cctcttctta 3301 acaacatacc catggccaac ctcctactcc tcattgtacc cattctaatc gcaatggcat 3361 tcctaatgct taccgaacga aaaattctag gctatataca actacgcaaa ggccccaacg 3421 ttgtaggccc ctacgggcta ctacaaccct tcgctgacgc cataaaactc ttcaccaaag 3481 agcccctaaa acccgccaca tctaccatca ccctctacat caccgccccg accttagctc 3541 tcaccatcgc tcttctacta tgaacccccc tccccatacc caaccccctg gtcaacctca 3601 acctaggcct cctatttatt ctagccacct ctagcctagc cgtttactca atcctctgat 3661 cagggtgagc atcaaactca aactacgccc tgatcggcgc actgcgagca gtagcccaaa 3721 caatctcata tgaagtcacc ctagccatca ttctactatc aacattacta ataagtggct 3781 cctttaacct ctccaccctt atcacaacac aagaacacct ctgattactc ctgccatcat 3841 gacccttggc cataatatga tttatctcca cactagcaga gaccaaccga acccccttcg 3901 accttgccga aggggagtcc gaactagtct caggcttcaa catcgaatac gccgcaggcc 3961 ccttcgccct attcttcata gccgaataca caaacattat tataataaac accctcacca 4021 ctacaatctt cctaggaaca acatatgacg cactctcccc tgaactctac acaacatatt 4081 ttgtcaccaa gaccctactt ctaacctccc tgttcttatg aattcgaaca gcataccccc 4141 gattccgcta cgaccaactc atacacctcc tatgaaaaaa cttcctacca ctcaccctag 4201 cattacttat atgacatgtc tccataccca ttacaatctc cagcattccc cctcaaacct 4261 aagaaatatg tctgataaaa gagttacttt gatagagtaa ataataggag cttaaacccc 4321 cttatttcta ggactatgag aatcgaaccc atccctgaga atccaaaatt ctccgtgcca 4381 cctatcacac cccatcctaa agtaaggtca gctaaataag ctatcgggcc cataccccga 4441 aaatgttggt tatacccttc ccgtactaat taatcccctg gcccaacccg tcatctactc 4501 taccatcttt gcaggcacac tcatcacagc gctaagctcg cactgatttt ttacctgagt 4561 aggcctagaa ataaacatgc tagcttttat tccagttcta accaaaaaaa taaaccctcg 4621 ttccacagaa gctgccatca agtatttcct cacgcaagca accgcatcca taatccttct 4681 aatagctatc ctcttcaaca atatactctc cggacaatga accataacca atactaccaa 4741 tcaatactca tcattaataa tcataatggc tatagcaata aaactaggaa tagccccctt 4801 tcacttctga gtcccagagg ttacccaagg cacccctctg acatccggcc tgcttcttct 4861 cacatgacaa aaactagccc ccatctcaat catataccaa atctctccct cactagacgt 4921 aagccttctc ctcactctct caatcttatc catcatagca ggcagttgag gtggattaaa 4981 ccaaacccag ctacgcaaaa tcttagcata ctcctcaatt acccacatag gatgaataat 5041 agcagttcta ccgtacaacc ctaacataac cattcttaat ttaactattt atattatcct 5101 aactactacc gcattcctac tactcaactt aaactccagc accacaaccc tactactatc 5161 tcgcacctga aacaagctaa catgactaac acccttaatt ccatccaccc tcctctccct 5221 aggaggcctg cccccgctaa ccggcttttt gcccaaatgg gccattatcg aagaattcac 5281 aaaaaacaat agcctcatca tccccaccat catagccacc atcaccctcc ttaacctcta 5341 cttctaccta cgcctaatct actccacctc aatcacacta ctccccatat ctaacaacgt 5401 aaaaataaaa tgacagtttg aacatacaaa acccacccca ttcctcccca cactcatcgc 5461 ccttaccacg ctactcctac ctatctcccc ttttatacta ataatcttat agaaatttag 5521 gttaaataca gaccaagagc cttcaaagcc ctcagtaagt tgcaatactt aatttctgta 5581 acagctaagg actgcaaaac cccactctgc atcaactgaa cgcaaatcag ccactttaat 5641 taagctaagc ccttactaga ccaatgggac ttaaacccac aaacacttag ttaacagcta 5701 agcaccctaa tcaactggct tcaatctact tctcccgccg ccgggaaaaa aggcgggaga 5761 agccccggca ggtttgaagc tgcttcttcg aatttgcaat tcaatatgaa aatcacctcg 5821 gagctggtaa aaagaggcct aacccctgtc tttagattta cagtccaatg cttcactcag 5881 ccattttacc tcacccccac tgatgttcgc cgaccgttga ctattctcta caaaccacaa 5941 agacattgga acactatacc tattattcgg cgcatgagct ggagtcctag gcacagctct 6001 aagcctcctt attcgagccg agctgggcca gccaggcaac cttctaggta acgaccacat 6061 ctacaacgtt atcgtcacag cccatgcatt tgtaataatc ttcttcatag taatacccat 6121 cataatcgga ggctttggca actgactagt tcccctaata atcggtgccc ccgatatggc 6181 gtttccccgc ataaacaaca taagcttctg actcttacct ccctctctcc tactcctgct 6241 cgcatctgct atagtggagg ccggagcagg aacaggttga acagtctacc ctcccttagc 6301 agggaactac tcccaccctg gagcctccgt agacctaacc atcttctcct tacacctagc 6361 aggtgtctcc tctatcttag gggccatcaa tttcatcaca acaattatca atataaaacc 6421 ccctgccata acccaatacc aaacgcccct cttcgtctga tccgtcctaa tcacagcagt 6481 cctacttctc ctatctctcc cagtcctagc tgctggcatc actatactac taacagaccg 6541 caacctcaac accaccttct tcgaccccgc cggaggagga gaccccattc tataccaaca 6601 cctattctga tttttcggtc accctgaagt ttatattctt atcctaccag gcttcggaat 6661 aatctcccat attgtaactt actactccgg aaaaaaagaa ccatttggat acataggtat 6721 ggtctgagct atgatatcaa ttggcttcct agggtttatc gtgtgagcac accatatatt 6781 tacagtagga atagacgtag acacacgagc atatttcacc tccgctacca taatcatcgc 6841 tatccccacc ggcgtcaaag tatttagctg actcgccaca ctccacggaa gcaatatgaa 6901 atgatctgct gcagtgctct gagccctagg attcatcttt cttttcaccg taggtggcct 6961 gactggcatt gtattagcaa actcatcact agacatcgta ctacacgaca cgtactacgt 7021 tgtagctcac ttccactatg tcctatcaat aggagctgta tttgccatca taggaggctt 7081 cattcactga tttcccctat tctcaggcta caccctagac caaacctacg ccaaaatcca 7141 tttcactatc atattcatcg gcgtaaatct aactttcttc ccacaacact ttctcggcct 7201 atccggaatg ccccgacgtt actcggacta ccccgatgca tacaccacat gaaacatcct 7261 atcatctgta ggctcattca tttctctaac agcagtaata ttaataattt tcatgatttg 7321 agaagccttc gcttcgaagc gaaaagtcct aatagtagaa gaaccctcca taaacctgga 7381 gtgactatat ggatgccccc caccctacca cacattcgaa gaacccgtat acataaaatc 7441 tagacaaaaa aggaaggaat cgaacccccc aaagctggtt tcaagccaac cccatggcct 7501 ccatgacttt ttcaaaaagg tattagaaaa accatttcat aactttgtca aagttaaatt 7561 ataggctaaa tcctatatat cttaatggca catgcagcgc aagtaggtct acaagacgct 7621 acttccccta tcatagaaga gcttatcacc tttcatgatc acgccctcat aatcattttc 7681 cttatctgct tcctagtcct gtatgccctt ttcctaacac tcacaacaaa actaactaat 7741 actaacatct cagacgctca ggaaatagaa accgtctgaa ctatcctgcc cgccatcatc 7801 ctagtcctca tcgccctccc atccctacgc atcctttaca taacagacga ggtcaacgat 7861 ccctccctta ccatcaaatc aattggccac caatggtact gaacctacga gtacaccgac 7921 tacggcggac taatcttcaa ctcctacata cttcccccat tattcctaga accaggcgac 7981 ctgcgactcc ttgacgttga caatcgagta gtactcccga ttgaagcccc cattcgtata 8041 ataattacat cacaagacgt cttgcactca tgagctgtcc ccacattagg cttaaaaaca 8101 gatgcaattc ccggacgtct aaaccaaacc actttcaccg ctacacgacc gggggtatac 8161 tacggtcaat gctctgaaat ctgtggagca aaccacagtt tcatgcccat cgtcctagaa 8221 ttaattcccc taaaaatctt tgaaataggg cccgtattta ccctatagca ccccctctac 8281 cccctctaga gcccactgta aagctaactt agcattaacc ttttaagtta aagattaaga 8341 gaaccaacac ctctttacag tgaaatgccc caactaaata ctaccgtatg gcccaccata 8401 attaccccca tactccttac actattcctc atcacccaac taaaaatatt aaacacaaac 8461 taccacctac ctccctcacc aaagcccata aaaataaaaa attataacaa accctgagaa 8521 ccaaaatgaa cgaaaatctg ttcgcttcat tcattgcccc cacaatccta ggcctacccg 8581 ccgcagtact gatcattcta tttccccctc tattgatccc cacctccaaa tatctcatca 8641 acaaccgact aatcaccacc caacaatgac taatcaaact aacctcaaaa caaatgataa 8701 ccatacacaa cactaaagga cgaacctgat ctcttatact agtatcctta atcattttta 8761 ttgccacaac taacctcctc ggactcctgc ctcactcatt tacaccaacc acccaactat 8821 ctataaacct agccatggcc atccccttat gagcgggcgc agtgattata ggctttcgct 8881 ctaagattaa aaatgcccta gcccacttct taccacaagg cacacctaca ccccttatcc 8941 ccatactagt tattatcgaa accatcagcc tactcattca accaatagcc ctggccgtac 9001 gcctaaccgc taacattact gcaggccacc tactcatgca cctaattgga agcgccaccc 9061 tagcaatatc aaccattaac cttccctcta cacttatcat cttcacaatt ctaattctac 9121 tgactatcct agaaatcgct gtcgccttaa tccaagccta cgttttcaca cttctagtaa 9181 gcctctacct gcacgacaac acataatgac ccaccaatca catgcctatc atatagtaaa 9241 acccagccca tgacccctaa caggggccct ctcagccctc ctaatgacct ccggcctagc 9301 catgtgattt cacttccact ccataacgct cctcatacta ggcctactaa ccaacacact 9361 aaccatatac caatgatggc gcgatgtaac acgagaaagc acataccaag gccaccacac 9421 accacctgtc caaaaaggcc ttcgatacgg gataatccta tttattacct cagaagtttt 9481 tttcttcgca ggatttttct gagcctttta ccactccagc ctagccccta ccccccaatt 9541 aggagggcac tggcccccaa caggcatcac cccgctaaat cccctagaag tcccactcct 9601 aaacacatcc gtattactcg catcaggagt atcaatcacc tgagctcacc atagtctaat 9661 agaaaacaac cgaaaccaaa taattcaagc actgcttatt acaattttac tgggtctcta 9721 ttttaccctc ctacaagcct cagagtactt cgagtctccc ttcaccattt ccgacggcat 9781 ctacggctca acattttttg tagccacagg cttccacgga cttcacgtca ttattggctc 9841 aactttcctc actatctgct tcatccgcca actaatattt cactttacat ccaaacatca 9901 ctttggcttc gaagccgccg cctgatactg gcattttgta gatgtggttt gactatttct 9961 gtatgtctcc atctattgat gagggtctta ctcttttagt ataaatagta ccgttaactt 10021 ccaattaact agttttgaca acattcaaaa aagagtaata aacttcgcct taattttaat 10081 aatcaacacc ctcctagcct tactactaat aattattaca ttttgactac cacaactcaa 10141 cggctacata gaaaaatcca ccccttacga gtgcggcttc gaccctatat cccccgcccg 10201 cgtccctttc tccataaaat tcttcttagt agctattacc ttcttattat ttgatctaga 10261 aattgccctc cttttacccc taccatgagc cctacaaaca actaacctgc cactaatagt 10321 tatgtcatcc ctcttattaa tcatcatcct agccctaagt ctggcctatg agtgactaca 10381 aaaaggatta gactgaaccg aattggtata tagtttaaac aaaacgaatg atttcgactc 10441 attaaattat gataatcata tctaccaaat gcccctcatt tacataaata ttatactagc 10501 atttaccatc tcacttctag gaatactagt atatcgctca cacctcatat cctccctact 10561 atgcctagaa ggaataatac tatcgctgtt cattatagct actctcataa ccctcaacac 10621 ccactccctc ttagccaata ttgtgcctat tgccatacta gtctttgccg cctgcgaagc 10681 agcggtgggc ctagccctac tagtctcaat ctccaacaca tatggcctag actacgtaca 10741 taacctaaac ctactccaat gctaaaacta atcgtcccaa caattatatt actaccactg 10801 acatgacttt ccaaaaaaca cataatttga atcaacacaa ccacccacag cctaattatt 10861 agcatcatcc ctctactatt ttttaaccaa atcaacaaca acctatttag ctgttcccca 10921 accttttcct ccgaccccct aacaaccccc ctcctaatac taactacctg actcctaccc 10981 ctcacaatca tggcaagcca acgccactta tccagtgaac cactatcacg aaaaaaactc 11041 tacctctcta tactaatctc cctacaaatc tccttaatta taacattcac agccacagaa 11101 ctaatcatat tttatatctt cttcgaaacc acacttatcc ccaccttggc tatcatcacc 11161 cgatgaggca accagccaga acgcctgaac gcaggcacat acttcctatt ctacacccta 11221 gtaggctccc ttcccctact catcgcactg atttacactc acaacaccct aggctcacta 11281 aacattctac tactcactct cactgcccaa gaactatcaa actcctgagc caacaactta 11341 atatgactag cttacacaat agcttttata gtaaagatac ctctttacgg actccactta 11401 tgactcccta aagcccatgt cgaagccccc atcgctgggt caatagtact tgccgcagta 11461 ctcttaaaac taggcggcta tggtataata cgcctcacac tcattctcaa ccccctgaca 11521 aaacacatag cctacccctt ccttgtacta tccctatgag gcataattat aacaagctcc 11581 atctgcctac gacaaacaga cctaaaatcg ctcattgcat actcttcaat cagccacata 11641 gccctcgtag taacagccat tctcatccaa accccctgaa gcttcaccgg cgcagtcatt 11701 ctcataatcg cccacggact tacatcctca ttactattct gcctagcaaa ctcaaactac 11761 gaacgcactc acagtcgcat cataatcctc tctcaaggac ttcaaactct gctcccacta 11821 atagcttttt gatgacttct agcaagcctc gctaacctcg ccttaccccc cactattaac 11881 ctactgggag aactctctgt gctagtaacc acgttctcct gatcaaatat cactctccta 11941 cttacaggac tcaacatact agtcacagcc ctatactccc tctacatatt taccacaaca 12001 caatggggct cactcaccca ccacattaac aacataaaac cctcattcac acgagaaaac 12061 accctcatgt tcatacacct atcccccatt ctcctcctat ccctcaaccc cgacatcatt 12121 accgggtttt cctcttgtaa atatagttta accaaaacat cagattgtga atctgacaac 12181 agaggcttac gaccccttat ttaccgagaa agctcacaag aactgctaac tcatgccccc 12241 atgtctaaca acatggcttt ctcaactttt aaaggataac agctatccat tggtcttagg 12301 ccccaaaaat tttggtgcaa ctccaaataa aagtaataac catgcacact actataacca 12361 ccctaaccct gacttcccta attcccccca tccttaccac cctcgttaac cctaacaaaa 12421 aaaactcata cccccattat gtaaaatcca ttgtcgcatc cacctttatt atcagtctct 12481 tccccacaac aatattcatg tgcctagacc aagaagttat tatctcgaac tgacactgag 12541 ccacaaccca aacaacccag ctctccctaa gcttcaaact agactacttc tccataatat 12601 tcatccctgt agcattgttc gttacatggt ccatcataga attctcactg tgatatataa 12661 actcagaccc aaacattaat cagttcttca aatatctact catcttccta attaccatac 12721 taatcttagt taccgctaac aacctattcc aactgttcat cggctgagag ggcgtaggaa 12781 ttatatcctt cttgctcatc agttgatgat acgcccgagc agatgccaac acagcagcca 12841 ttcaagcaat cctatacaac cgtatcggcg atatcggttt catcctcgcc ttagcatgat 12901 ttatcctaca ctccaactca tgagacccac aacaaatagc ccttctaaac gctaatccaa 12961 gcctcacccc actactaggc ctcctcctag cagcagcagg caaatcagcc caattaggtc 13021 tccacccctg actcccctca gccatagaag gccccacccc agtctcagcc ctactccact 13081 caagcactat agttgtagca ggaatcttct tactcatccg cttccacccc ctagcagaaa 13141 atagcccact aatccaaact ctaacactat gcttaggcgc tatcaccact ctgttcgcag 13201 cagtctgcgc ccttacacaa aatgacatca aaaaaatcgt agccttctcc acttcaagtc 13261 aactaggact cataatagtt acaatcggca tcaaccaacc acacctagca ttcctgcaca 13321 tctgtaccca cgccttcttc aaagccatac tatttatgtg ctccggatcc atcatccaca 13381 accttaacaa tgaacaagat attcgaaaaa taggaggact actcaaaacc atacctctca 13441 cttcaacctc cctcaccatt ggcagcctag cattagcagg aatacctttc ctcacaggtt 13501 tctactccaa agaccacatc atcgaaaccg caaacatatc atacacaaac gcctgagccc 13561 tatctattac tctcatcgct acctccctga caagcgccta tagcactcga ataattcttc 13621 tcaccctaac aggtcaacct cgcttcccca cccttactaa cattaacgaa aataacccca 13681 ccctactaaa ccccattaaa cgcctggcag ccggaagcct attcgcagga tttctcatta 13741 ctaacaacat ttcccccgca tcccccttcc aaacaacaat ccccctctac ctaaaactca 13801 cagccctcgc tgtcactttc ctaggacttc taacagccct agacctcaac tacctaacca 13861 acaaacttaa aataaaatcc ccactatgca cattttattt ctccaacata ctcggattct 13921 accctagcat cacacaccgc a