LOCUS AY182376 17538 bp DNA circular INV 09-MAR-2004 DEFINITION Cucumaria miniata mitochondrion, complete genome. ACCESSION AY182376 AF009128 AF009349 AF009350 S64536 U32215 VERSION AY182376.1 GI:37730861 KEYWORDS . SOURCE mitochondrion Cucumaria miniata ORGANISM Cucumaria miniata Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea; Dendrochirotacea; Dendrochirotida; Cucumariidae; Cucumaria. REFERENCE 1 (bases 17291 to 17538; 1 to 78) AUTHORS Smith,M.J., Arndt,A., Gorski,S. and Fajber,E. TITLE The phylogeny of echinoderm classes based on mitochondrial gene arrangements JOURNAL J. Mol. Evol. 36 (6), 545-554 (1993) MEDLINE 93353526 PUBMED 8350349 REFERENCE 2 (bases 17124 to 17538; 1 to 876) AUTHORS Arndt,A., Marquez,C., Lambert,P. and Smith,M.J. TITLE Molecular phylogeny of eastern Pacific sea cucumbers (Echinodermata: Holothuroidea) based on mitochondrial DNA sequence JOURNAL Mol. Phylogenet. Evol. 6 (3), 425-437 (1996) MEDLINE 97131649 PUBMED 8975697 REFERENCE 3 (bases 1 to 4114; 12708 to 15090) AUTHORS Arndt,A. and Smith,M.J. TITLE Mitochondrial gene rearrangement in the sea cucumber genus Cucumaria JOURNAL Mol. Biol. Evol. 15 (8), 1009-1016 (1998) MEDLINE 98384840 PUBMED 9718728 REFERENCE 4 (bases 1 to 17538) AUTHORS Scouras,A., Beckenbach,K., Arndt,A. and Smith,M.J. TITLE Complete mitochondrial genome DNA sequence for two ophiuroids and a holothuroid: the utility of protein gene sequence and gene maps in the analyses of deep deuterostome phylogeny JOURNAL Mol. Phylogenet. Evol. 31 (1), 50-65 (2004) REFERENCE 5 (bases 1 to 17538) AUTHORS Scouras,A., Beckenbach,K., Arndt,A. and Smith,M.J. TITLE Direct Submission JOURNAL Submitted (18-NOV-2002) Molecular Biology and Biochemisty, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia V5A 1S6, Canada COMMENT On or before Mar 9, 2004 this sequence version replaced gi:3282253, gi:3282246, gi:1046324, gi:3282255, gi:409342. FEATURES Location/Qualifiers source 1..17538 /organism="Cucumaria miniata" /organelle="mitochondrion" /mol_type="genomic DNA" /db_xref="taxon:28833" gene 1..1551 /gene="cox1" CDS 1..1551 /gene="cox1" /codon_start=1 /transl_table=9 /product="cytochrome c oxidase subunit I" /protein_id="AAR02385.1" /db_xref="GI:37730862" /translation="MNLNRWLFSTNHKDIGTLYLLFGAWAGMIGTAMSVIIRTELAQP GSLLNDDQIYNTIVTAHALVMIFFMVMPIMIGGFGNWLIPLMIGAPDMAFPRMNNMSF WLIPPSFILLLASAGVENGAGTGWTIYPPLSSNIAHAGGSVDLAIFSLHLAGASSILA SINFITTIINMRSPGITFDRLPLFVWSVFITAFLLLLSLPVLAGAITMLLTDRNINTS FFDPAGGGDPILFQHLFWFFGHPEVYILILPGFGMISHVIAHYSGKQEPFGYLGMVYA MVAIGILGFLVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKVFSWMATLQGSKLIW ETPLLWALGFVFLFTIGGLTGIVLANSSIDVIVHDTYYVVAHFHYVLSMGAVFAIFAG FTHWFPIISGTSLHPLWSKVQFFIMFIGVNLTFFPQHFLGLAGMPRRYTDYPDAYTTW NTVSSIGSIISLVGAILFLFLIWEAFIAQRNVIAPQFIESSLEWQYSEYPPSHHTFEE TPITFIPS" tRNA 1551..1616 /product="tRNA-Arg" /anticodon=(pos:1579..1581,aa:Arg) repeat_region 1617..2775 tRNA 2776..2843 /product="tRNA-Glu" /anticodon=(pos:2805..2807,aa:Glu) misc_feature 2844..3248 /note="duplicated putative control region" tRNA 3249..3315 /product="tRNA-Pro" /anticodon=(pos:3278..3280,aa:Pro) tRNA 3335..3404 /product="tRNA-Asn" /anticodon=(pos:3366..3368,aa:Asn) tRNA 3408..3478 /product="tRNA-Leu" /note="codons recognized: CUN" /anticodon=(pos:3440..3442,aa:Leu) tRNA 3537..3605 /product="tRNA-Trp" /anticodon=(pos:3567..3569,aa:Trp) tRNA complement(3670..3739) /product="tRNA-Val" /anticodon=(pos:3706..3708,aa:Val) gene 3818..4114 /gene="nad4L" CDS 3818..4114 /gene="nad4L" /codon_start=1 /transl_table=9 /product="NADH dehydrogenase subunit 4L" /protein_id="AAR02386.1" /db_xref="GI:37730863" /translation="MNILTSILFSLFFLGVLGVVINRLHLLSLLLCLELLLISLFLNI TIWASTFSSLLTLNYSILLVTFSACEASAGLALMVSLSRSHNTDLLAQINLLQS" gene 4115..4804 /gene="cox2" CDS 4115..4804 /gene="cox2" /codon_start=1 /transl_table=9 /product="cytochrome c oxidase subunit II" /protein_id="AAR02387.1" /db_xref="GI:37730864" /translation="MATWAQLGLQDASSPLMEELVYFHDYTLIILTLIIILVFYGLLT ILSSSFTNRFFLEGQELETIWTVIPAIILIFIAFPSLQILYLMDEVNTPYLTVKAIGH QWYWSYEYTDYNDIEFDSYMTPTEDLQNGEPRLLEVDNRLILPYQNPIRALITSSDVI HSWAVPSLGIKMDAIPGRLNQTSFLINRTGLFYGQCSEICGANHSFMPIVIESVPFDS FQTWISNNIEE" tRNA 4806..4869 /product="tRNA-Lys" /anticodon=(pos:4836..4838,aa:Lys) gene 4870..5037 /gene="atp8" CDS 4870..5037 /gene="atp8" /codon_start=1 /transl_table=9 /product="ATPase subunit 8" /protein_id="AAR02388.1" /db_xref="GI:37730865" /translation="MPQLDLSWFLVNFLLAWSLIFVIWVIINIQTWNTQNTLNNSNNE SQNLPQENWNW" gene 5031..5714 /gene="atp6" CDS 5031..5714 /gene="atp6" /codon_start=1 /transl_table=9 /product="ATPase subunit 6" /protein_id="AAR02389.1" /db_xref="GI:37730866" /translation="MINSLFSQFTPDTLIFLPLQILASFIAILWLIILYPTNFFSGHI TYIWNQIRLEALKLIFQNVKNKSAPWISSLSAIFFLILSINLLGLFPYTFSITSHVSF TYSIAIPLWLSVNILGFYLAFNSRLSHLVPQGTPPFLIPFMVWIETLSLFAQPLALGL RLAANLTAGHLLLFLFSSAAWVLSNNLILSSITIVILILIFILEIGVACIQAYVFTSL INFYLDQNI" gene 5716..6498 /gene="cox3" CDS 5716..6498 /gene="cox3" /codon_start=1 /transl_table=9 /product="cytochrome c oxidase subunit III" /protein_id="AAR02390.1" /db_xref="GI:37730867" /translation="MTHQHPFHLVDQSPWPLTAAFGALIMTSGLIIWFHLGTINIFLI GLIVTTLTSINWWRDVIREATFQGHHTLIVINGLRYGMILFITSEVCFFFAFFWAFFH SSLAPTIEIGVSWPPTGITPLNPFLVPLLNTAVLLSSGVTITWAHHSIIENNRNEAIQ ALSLTVLLGLYFTSLQAWEYLDAPFTIADSVYGSTFFVATGFHGLHVIIGTTFLGVCL LRLINHHFSNYHHFGFEAAAWYWHFVDVVWLFLYVCVYWWGS" tRNA complement(6500..6570) /product="tRNA-Ser" /note="codons recognized: UCN" /anticodon=(pos:6536..6538,aa:Ser) gene 6589..6933 /gene="nad3" CDS 6589..6933 /gene="nad3" /codon_start=1 /transl_table=9 /product="NADH dehydrogenase subunit 3" /protein_id="AAR02391.1" /db_xref="GI:37730868" /translation="MNLIAFLLIAIILSSLLILVGHFLPNRQLELNKNSPYECGFDPI NSARLPFSFRFFLVAILFLIFDLEIALLFPILPSLNNNIYNLFFLSSMFLIILASGLA YEWQQGGLEWAE" gene 6937..8290 /gene="nad4" CDS 6937..8290 /gene="nad4" /note="TAA stop codon is completed by addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:8290,aa:TERM) /transl_table=9 /product="NADH dehydrogenase subunit 4" /protein_id="AAR02392.1" /db_xref="GI:37730869" /translation="MLTLLIASLSIICLNFIPRWNWISLFYSFSMITFLSINLLNNQT QTWNNVSINLGSDNLSTPLIVLSCWLAPLCFMSNNIIKNENQNAQNTFLFLISFITTF LILTFSSLNVLSFFICFEATLIPTLILITRLGANVERLQAGLYFLFYTLFGSLPLLVS LLIINNNHLNLNFSLNPPINEQIPLNIINIWWIITIIAFLVKMPIYGFHLWLPKAHVE APIAGSMILAAILLKLGGYGLIRLNLFFLNTNNINSILIIFCCWGTLITSIICIRQTD LKALIAYSSVGHMSLTASGIFLFSNWSVSGALMLMIAHGLVSSALFALANILYERTHT RNISITRGFKTITVLLPIWWIIACVANLGLPPLPNLIGEIIIISGLLGWNLWLIPILG LATVFGAIYSLSIFQNTNTQKNLNLSNKYQTINPREHLLIILHFAPLIFIILNPSPCF I" tRNA 8291..8357 /product="tRNA-His" /anticodon=(pos:8319..8321,aa:His) tRNA 8358..8424 /product="tRNA-Ser" /note="codons recognized: AGN" /anticodon=(pos:8383..8385,aa:Ser) gene 8425..10248 /gene="nad5" CDS 8425..10248 /gene="nad5" /codon_start=1 /transl_table=9 /product="NADH dehydrogenase subunit 5" /protein_id="AAR02393.1" /db_xref="GI:37730870" /translation="MNINLYYINATLTLLIFLMLTLASSFSSKNQENSIRSLNNQNIT LYTLKIISIIAVINLIVFVTNDNNLLLNLLNWNNDFNINFNLTIFLDNNFIFFLTTAL IVTWSIIEFSIYYMESDPLSTNFFRLLTIFLLNMLILTSSNNLFIFFIGWEGVGFLSF LLIGWWFTRNEANTAALQAIIYNRIGDIGIIMLIAGVLIISNGWNITNINFVNNSSPN WQNILLFATLIAAIGKSAQFSLHAWLPAAMEGPTPVSALLHSSTMVVAGVFLLIRVTN FTSNTTFLTTCSIIGALTAIFAATSAFRQHDIKKIIAYSTTSQLGLMVLAIGLGFPNI ALFHICTHAFFKAMLFLCSGSIIHSHNNEQDLRKISNINLSLPITSACLTLGSVTLMG VPFLSGFFSKDLILESIINNPVNISSFLLATSATFLTAAYSFRIITFCFNNNTNENAS NPINEENPSLYLPLTRLATGTILYGWFLSNWLFNIPPLFPLTIVKSTPLIVTILGAIL AATIILSINNKINITFFTKTWFFNNITHIITNTLTSNIALIMSTRTLDRGWNELIGGQ GVFLANKTAAQSSNTAQTGYIKQYLLSIFIISISILLLTSI" gene complement(10262..10747) /gene="nad6" CDS complement(10262..10747) /gene="nad6" /codon_start=1 /transl_table=9 /product="NADH dehydrogenase subunit 6" /protein_id="AAR02394.1" /db_xref="GI:37730871" /translation="MVFYLFMVFLLLGSTMVFYSLSPYYAALGLVLSSLFGCVILGFC GVSFLALLLLLIYMGGMLVVFIYSSALSADRFPVVSNLGEVIVLFLLMCFWVLFIFED FLELSVMGDLVGFQGLSSLGELYSFGGFYLLIGGLALLVVLVVALVISFSFSEVSLRA L" gene 10756..11896 /gene="cob" CDS 10756..11896 /gene="cob" /note="TAA stop codon is completed by addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:11896,aa:TERM) /transl_table=9 /product="cytochrome b" /protein_id="AAR02395.1" /db_xref="GI:37730872" /translation="MTSPIRKSHPLFRIVNSSLVDLPSPSNLSVWWNFGSLLGLCLII QILTGLFLSMHYTADISLAFSSVSHICRDVNNGWLLRNVHANTGSFFFICIYCHIGRG IYYGSYVNQETWNTGVILFLITMITAFVGYVLPWGQMSFWAATVITNLLSAIPYIGNE LVQWVWGGFSVDNATLSRFFSFHFLFPFIIAALSVIHLLFLHQTGSNNPTGLNSNIDK TPFHTYFSTKDIAGFILLIAGILTLALLAPTALNDPENFIPANPLITPTHIQPEWYFL FAYAILRSIPNKLGGVIALVAAVLIWFIIPLVHTSWNQSSTFRPLTQITFWVLIATFI ILTWIGSQPVEEPFIIIGQVASALYFSIFIIFFPFVATLENTIIKI" tRNA 11897..11967 /product="tRNA-Phe" /anticodon=(pos:11929..11931,aa:Phe) rRNA 11968..12848 /product="small subunit ribosomal RNA" tRNA 12849..12914 /product="tRNA-Thr" /anticodon=(pos:12876..12878,aa:Thr) misc_feature 12915..13366 /note="duplicated putative control region" tRNA complement(13367..13436) /product="tRNA-Gln" /anticodon=(pos:13403..13405,aa:Gln) tRNA complement(13534..13599) /product="tRNA-Ala" /anticodon=(pos:13568..13570,aa:Ala) tRNA 13628..13695 /product="tRNA-Cys" /anticodon=(pos:13658..13660,aa:Cys) tRNA 13754..13821 /product="tRNA-Met" /anticodon=(pos:13784..13786,aa:Met) tRNA complement(13835..13902) /product="tRNA-Asp" /anticodon=(pos:13871..13873,aa:Asp) tRNA 13905..13973 /product="tRNA-Tyr" /anticodon=(pos:13933..13935,aa:Tyr) tRNA 13973..14041 /product="tRNA-Gly" /anticodon=(pos:14002..14004,aa:Gly) tRNA 14047..14117 /product="tRNA-Leu" /note="codons recognized: UUR" /anticodon=(pos:14079..14081,aa:Leu) gene 14119..15090 /gene="nad1" CDS 14119..15090 /gene="nad1" /codon_start=1 /transl_table=9 /product="NADH dehydrogenase subunit 1" /protein_id="AAC69445.2" /db_xref="GI:45272591" /translation="MSTALFTIQALIYIVPILLSVAFLTLVERKVLGYMQFRKGPNIV GPYGILQPFADALKLFVKETLKPSTASPFLFFFSPFLFLTLAITLWSLVPLPNTSLNI NLSLLLILGLSSLSVYSLIGAGWASNSKYSLIGGIRAVAQTISYEISMGLIILSILLW VNSFSLKDINEIQNNWWIILPYFSLFIMWIVSTLAETNRAPFDLTEGESELVSGYNVE YAGGPFALFFIAEYANIIFMNLLSVLIFLGGSSPFSETPIISSLTIALKTLLLVFWFL WVRASYPRFRYDQLMHLTWKNYLPFSLGILCITITVIILLNGNIPNL" tRNA 15106..15175 /product="tRNA-Ile" /anticodon=(pos:15136..15138,aa:Ile) gene 15176..16219 /gene="nad2" CDS 15176..16219 /gene="nad2" /codon_start=1 /transl_table=9 /product="NADH dehydrogenase subunit 2" /protein_id="AAR02396.1" /db_xref="GI:37730873" /translation="MNRIIIIFLISSLVIGTTLVIFSNHWFPIWLGLELSTLSIIPIL NTNIKSRSNEATTKYFLVQAFSAAILLNGATLNLWLSNSWNISETPNTISYIIILIAI IIKLGIAPCHFWFPDVLSGLPFSNGIIIACWQKIAPLFILLSISNNIPNEIILLCATL SILIGGWGGLNQISIRKILAYSSISHLGWVSATLFFSPEASLILFSFYIINNTSIFLL CHNNNLLSLANLNKTNLILPITLLFSIFLLSLGGLPPLGGFLNKLIPFIIFLNNINWI FIPSLIFGSLTSLYFYLRIVFNTSLTLFPNNSLNFLFNNNNNSNYLNTIISILTPLPI FGLVLIPTFSLFI" rRNA 16220..17538 /product="large subunit ribosomal RNA" ORIGIN 1 atgaaactaa accgctgatt attttcaact aaccacaagg acattggaac actctaccta 61 ctattcggtg cctgagcagg aatgatcggg acagcaatga gagtaattat ccgaaccgaa 121 ctcgcacaac ctggatccct acttaaagac gaccagatat acaaaactat agtgacagcc 181 cacgccttag tcatgatttt cttcatggtg atgccaataa tgataggagg atttggaaac 241 tgattaatcc ccctaatgat aggagcccct gacatggcct tccctcgaat gaaaaatatg 301 agattctgac taatcccccc ttcatttatt ctccttctgg cctccgcagg agtagaaaaa 361 ggagcaggga ccggatgaac aatctacccc cctctatcaa gaaaaattgc ccacgcagga 421 gggtcagttg acctcgcgat cttctctctc cacctagcag gagcctcttc aatccttgct 481 tcaataaaat ttattactac aattataaaa atgcgaagac caggaataac tttcgaccga 541 ctacctttat ttgtctgatc agttttcata acagcctttc ttcttctcct tagtctccca 601 gtactagcag gagccataac aatgctccta acagaccgaa acatcaaaac atcattcttc 661 gaccccgcag gaggaggaga ccctatactc tttcaacact tattctgatt ctttggccat 721 ccagaagttt atatccttat actacccgga ttcggaatga tatctcacgt aatagctcac 781 tatagaggaa agcaagaacc ttttgggtac ctaggaatgg tatacgcaat ggtggcaatc 841 ggtatcctag gattcctagt atgagcacac catatgttca ccgtaggaat ggatgtagac 901 acacgagcct acttcacagc agctaccatg ataattgcag tcccaacagg aataaaggta 961 ttcagatgaa tggctacact ccaagggtca aagctaatat gagaaacccc actattatgg 1021 gctctaggat tcgtattcct attcacaata ggaggcctta caggaattgt cctagctaac 1081 tcctctatag acgtaatcgt acacgatact tattatgttg tggcccactt ccattatgta 1141 ctttccatgg gagcagtctt cgccatattt gcaggcttca cccactgatt ccccattatt 1201 tcaggaacct ccttacaccc cttatggtca aaggtacaat tcttcataat gtttatagga 1261 gtaaacctaa cattttttcc ccaacacttc ctagggctag caggtatgcc ccgccgatac 1321 actgactacc cagacgccta caccacatga aaaacagtct cctctatagg atctataatc 1381 tcactcgtag gagctatact tttcctattc ctaatatgag aagccttcat tgcccaacga 1441 aaagtaatag ccccccaatt catcgaatcc tccctagaat gacaatacag agaatacccc 1501 ccttctcacc acacctttga agaaaccccc ataacattca tccctagata gaaagattag 1561 tttaataaac ataaagcttc gacctttaaa ttcttagtaa agcctaagat ctttttaaaa 1621 tccaacccat aatccatctt ctaaagagta aagataaccc cctttaaagc ctttaataaa 1681 atattctata taatataata tttataaata aaaagataga actctatgga aaaccagatc 1741 ttcttaaaaa taaatttaac ctaataactc ctttagttta tcataaaaaa aataaaaaat 1801 tattttataa agaaggggac ccccttatat atttttccaa aagataaaat taacccccta 1861 ccccctaccg ctaaactatt aaattaaagc tttaccctta caaagagcct cccccccccc 1921 ctttttaaaa aagagtaaag ataaccccct ttaaagcctt taataaaata ttctatataa 1981 tataatattt ataaataaaa agatagaact ctatggaaaa ccagatcttc ttaaaaataa 2041 atttaaccta ataactcctt tagtttatca taaaaaaaat aaaaaattat tttataaaga 2101 aggggacccc cttatatatt tttccaaaag ataaaattaa ccccctaccc cctaccgcta 2161 aactattaaa ttaaagcttt acccttacaa agagcctccc cccccccctt tttaaaaaag 2221 agtaaagata acccccttta aagcctttaa taaaatattc tatataatat aatatttata 2281 aataaaaaga tagaactcta tggaaaacca gatcttctta aaaataaatt taacctaata 2341 actcctttag tttatcataa aaaaaataaa aaattatttt ataaagaagg ggaccccctt 2401 atatattttt ccaaaagata aaattaaccc cctaccccct accgctaaac tattaaatta 2461 aagctttacc cttacaaaga gcctcccccc cccccttttt aaaaaagagt aaagataacc 2521 ccctttaaag cctttaataa aatattctat ataatataat atttataaat aaaaagatag 2581 aactctatgg aaaaccagat cttcttaaaa ataaatttaa cctaataact cctttagttt 2641 atcataaaaa aaataaaaaa ttattttata aagaagggga cccccttata tatttttcca 2701 aaagataaaa ttaaccccct accccctacc gctaaactat taaattaaag ctttaccccc 2761 tctttcaaca caaaaactgc taaagtttag aaaaacgaag gcttttcaag ccttagaccc 2821 aggttaaacc cctggtagga gtgatgttca cccaggctaa taaaataaaa cccctaccag 2881 ccctcgctta acctaaactg agtaaaaaaa ccttcaaaac ttaacatatc ccaaaacctt 2941 aatcatccct tcccccactt aagaaagatt aaaaacttgg gcttcccccc tatataaccc 3001 cccttccatg atccttgagt accatccggg cttaaccact tttcaatagt cttttttctt 3061 tacttttggg gctcaacatc atttattcct ctcctcgtga tttccatatt aacttgctat 3121 tatttcttta ctctctgctc cttacctcgc acatacctat atattcacct tttggagaaa 3181 gagagggtag accggggggg ggtgtatcgt ttatataaat aatatattgt tatttatatt 3241 aatataaaca gaaactagtt tattaaaata gttattttgg ggataacaga tacagaccta 3301 gccctgtgtt tctgaaataa aacaaatctt taaatgggtt gaagctgaaa caatagcatt 3361 tggccgttaa ccaaaaggat gaaggttagt ccctttcaac ccagcaagtt taaatagcaa 3421 aatagtaatg cattagattt aggttctatt attaaaggtg caaatccttt tttaaacttt 3481 tgcccacact aaatttttaa atttaaacaa tatagaaact tacccccccc ccaaccgaag 3541 atttaagtta ataaaacttt gagccttcaa agctcaccac acaaatcaaa attttgtaat 3601 ctttgggact atccaaaacc ttcaccaact aaaagcacaa cccactaaat actagtctag 3661 tacaaatctt caaaacagtt cgagttgcac gaaccttaac tctgtgtaaa agagtcgctt 3721 actccctagc tatattctgt atttatataa atacccaaga caaaccccct attaaaaaaa 3781 gaaggtgctg ttaaacttat accacaaaat acgaaaaatg aacatactaa caagaatttt 3841 attctccctt ttcttcctcg gggttttagg agtggttata aaacggttac accttctctc 3901 ccttttactt tgtttagagc tacttttaat ctcccttttc ctaaaaataa caatatgagc 3961 tagaactttt agcagcctct taacccttaa ctactccata cttctagtaa ccttctccgc 4021 atgtgaagca agagcagggt tagccttaat ggtttcccta tctcgaagac acaacaccga 4081 ccttttagca caaattaaac tcttacaatc ataaatggca acttgagcac aactaggatt 4141 acaagatgca tcctctcctc taatggaaga gctagtctac tttcacgatt ataccttaat 4201 tatccttact ttaattatta ttttagtatt ttatgggctc cttaccatcc tttcctcctc 4261 ctttactaaa cgattctttc tcgaaggcca agaactagaa acaatttgaa cagtcatacc 4321 agcaatcata cttatattta ttgctttccc ctctctccaa attttgtact taatggacga 4381 agttaaaacc ccttacctca cagtaaaggc tatagggcat caatgatact gaagttatga 4441 atatactgac tataatgata tagagtttga ctcctatatg acccctacag aagacttaca 4501 aaaaggggaa ccccgcctcc tagaagtaga taaccgcctc attctaccgt accaaaaccc 4561 aatacgggct ctcatcacga gatctgatgt tatacactca tgagccgtgc catctctagg 4621 gataaagatg gatgcaatcc caggccgact aaaccaaacc tcctttctaa taaaccgaac 4681 aggactattc tatggtcaat gttccgaaat atgtggggct aaccacagat tcatgcctat 4741 cgtcattgaa tctgtcccat ttgactcctt tcaaacatga atctctaaaa atatagaaga 4801 ataaaccata gatagcttaa agaaagcttc aaactcttaa tttgatgatg aacattagtt 4861 ctctttggaa tgccacaact agacctctcc tgattccttg ttaacttctt actagcatga 4921 tccttaattt ttgttatttg agttataata aatatacaaa cctgaaaaac tcaaaacacc 4981 ctgaacaata gtaaaaaaga aagccaaaac ctaccccaag aaaaatgaaa atgataaaaa 5041 gactatttag acaattcacc ccagacacct taatattttt acccttacag attctagcct 5101 cctttattgc tatattatga ttaattatac tataccctac caaatttttc tcagggcata 5161 tcacttatat atggaatcaa atacgccttg aagccttaaa gcttatcttt caaaaagtta 5221 agaaaaagtc agctccatga atatcttccc tatcagccat atttttctta atcctctcca 5281 ttaaccttct cggcctattc ccttatacat tctctattac cagccacgta tcctttacct 5341 atagtatagc aataccacta tgattaagag ttaaaatact aggattttac ctagcattca 5401 aaagacgact aagacatcta gtcccccaag gaaccccccc attcctaatc ccatttatgg 5461 tctgaataga aaccctaagt ctttttgctc aacccttagc tctaggctta cgactagcag 5521 ccaacctcac agcaggacac ctcctcctat tcctattttc aagagctgcc tgagtcctaa 5581 gaaaaaacct tatactaaga agaataacaa tagttatctt aattttaata ttcattctag 5641 aaataggagt agcctgcata caagcttacg tatttacatc tctaataaac ttctacctag 5701 accaaaacat ttaatatgac acatcaacac ccttttcact tagttgacca aagcccctgg 5761 ccccttacag cggcctttgg agccctaata atgacatcag gattaataat atgatttcac 5821 ttaggaacca taaaaatctt cctaataggc ttaatagtaa caactcttac ctcaataaaa 5881 tgatgacgag atgttatacg agaagcaaca ttccaaggac accatacact aatcgttata 5941 aatggactac gttacgggat gatcctattt ataacttcag aagtttgctt cttctttgct 6001 ttcttctgag ccttcttcca tagaagtctt gccccaacaa tagaaatagg ggtctcttga 6061 cccccaacag gaataacccc tctcaaccca tttttagtac ccctattaaa cacagcagtc 6121 ctattatctt caggagttac aataacctga gctcaccaca gtattataga aaaaaaccga 6181 aaagaagcta tacaagctct ctccctaaca gtcctccttg gcctatactt tacctccctc 6241 caagcatgag aatacttaga tgccccattc acgatagcag atagagttta tggatcaaca 6301 ttctttgtag ccacaggatt ccacggactt cacgtaatta taggaaccac tttcctaggt 6361 gtatgcttac tacgacttat aaatcatcac ttctccaaat atcaccattt cggcttcgaa 6421 gccgcagcct gatactgaca ttttgtagat gtagtctgac tatttctata cgtttgtgta 6481 tactgatgag ggtcatagaa agagaaggaa ggagtttaac cttcatcgat tgatttcaag 6541 tcaaacacat ttctcgtctg ccacttctcc cgtttatata aatacaaaat gaacttaata 6601 gcatttcttc taatagcaat tatactttcc agcctactaa tacttgtggg ccacttctta 6661 ccaaatcgtc aattagaact aaataagaaa tccccttatg aatgtgggtt tgacccaata 6721 aaatcagccc gccttccttt ttcctttcga tttttcctag tagcaatcct ttttctaata 6781 tttgatttag aaatcgccct tttattccct atcctccctt ctcttaaaaa aaatatatac 6841 aatctattct ttttatcctc catgtttctg attatactag caagaggcct agcttacgaa 6901 tgacaacaag gaggactaga atgagccgaa taataaatgt taacccttct aatagcatcc 6961 ctatccatta tctgtctgaa cttcatccca cgatgaaaat gaatcagatt attttattct 7021 ttctctatga taacattcct ttcaataaac ctactaaaaa aacaaaccca aacatgaaaa 7081 aaagtaagaa taaacctagg gagagataac ttatcaaccc ccctaatagt tttaagctgt 7141 tgactagccc ccttatgttt catgtcaaaa aaaataataa agaaagaaaa tcaaaaagca 7201 caaaaaacct tcttattcct aatttcattt attacaacat tccttatctt gacattttct 7261 tctctaaaag tcttatcctt cttcatatgc ttcgaagcca ctttgatccc aaccctaata 7321 ttaataaccc ggctaggggc taaagttgaa cgtctacaag ccggactcta tttcttattt 7381 tacacactct ttggttccct cccccttcta gtctcactat taattataaa aaaaaaccac 7441 ctaaacctaa aattctcttt aaaaccccca ataaaagaac aaatacctct gaaaataatt 7501 aatatatgat gaataattac aattatagcc ttcctagtaa agatgcctat ttatggattc 7561 catctatggc tcccaaaggc acatgtagaa gccccaatag caggctctat gatacttgcc 7621 gcgatactac taaagttagg ggggtatgga ttaatccgct taaacttatt cttccttaaa 7681 acaaaaaaaa tcaacagaat cttaattatc ttctgctgct gaggaacatt aataacaaga 7741 attatttgta tccgacaaac agacctaaag gccttaatag cctactcatc agtagggcac 7801 atgagcctaa cagcctccgg tatatttttg ttcagaaact gaagagtaag aggagctcta 7861 atgctaatga tagcccatgg actagtctca tcagctctat ttgcattagc caaaatactt 7921 tatgaacgaa cccatacacg aaaaatatcc atcacacgag ggtttaagac aataaccgta 7981 ctcctcccaa tatgatgaat aatagcatgt gtggcaaaat taggattacc ccctctccca 8041 aaccttatag gggagataat aattatttct ggcctactag ggtgaaacct ctggctaatc 8101 ccaatcctag ggttagccac agtatttggg gccatctact ccttatcaat attccaaaaa 8161 acaaaaacac aaaagaacct aaaattgtct aaaaagtacc aaacaataaa accacgagaa 8221 cacctactca ttattcttca ttttgccccc ctaatcttca taatactaaa tccctcccca 8281 tgtttcatat gatttaaata gttataaaat actaatttgt ggcattagag atggtaatta 8341 aatttacctt taagtccaag atttatagat tgattctggt ctgctaaacc atgaagcctg 8401 tggtttgact ccatagaaat cttgatgaat ataaaattat attacataaa agcaacactt 8461 acccttctta ttttcctcat gctaacacta gcctcctcat tctcctcaaa gaaacaagaa 8521 aaaagaatcc gaagcctaaa taaacaaaaa ataactttat acacacttaa gataatatcc 8581 atcatagccg tgatcaacct tattgtcttc gtaacaaaag ataaaaaact tctccttaac 8641 ctattaaact gaaaaaaaga ttttaaaata aaattcaaat taacaatctt tctagataaa 8701 aactttatat tctttttaac aaccgctctt atcgtaacct gatctatcat cgaattctca 8761 atatactaca tggaaagaga ccctctctct acaaaattct tccgattact cacaatcttc 8821 ctcctaaaca tgctaatact tacctcttcc aaaaaattat ttatattctt tataggctgg 8881 gaaggtgtag gattcctatc gttcttacta ataggctggt gattcacacg taaagaagca 8941 aaaacagccg ctctacaagc catcatttat aaccgaatag gagacatagg gataataatg 9001 ctaatagccg gagtactcat tatctcaaaa ggatgaaaaa taacaaaaat aaaatttgtt 9061 aaaaaaagat ctcctaaatg acaaaaaata ctcctattcg caaccctaat agccgccata 9121 ggtaagtccg cccaattctc tctccacgca tgactcccag ctgcaatgga aggacccacc 9181 cccgtatccg ccctactaca cagatcaaca atggtggtag caggagtctt cctcctaata 9241 cgagtcacaa aatttacatc taacaccact ttcctaacaa catgttcaat aataggggcc 9301 ttaacagcta tatttgcagc aacctcagca ttccgtcaac atgatatcaa gaagattatt 9361 gcatactcta caacaagaca actaggctta atggttctag ctatagggct aggtttccca 9421 aaaatagcct tatttcacat ctgtactcat gccttcttta aggcaatgct attcttatgt 9481 tcaggaagaa ttattcacag acataaaaaa gaacaagacc tccgaaagat atcaaaaatt 9541 aaattatccc tcccaataac ctccgcatgt ctcacccttg gtagtgtcac actaatggga 9601 gtcccattcc taagaggatt cttctctaag gacttaatat tagaatctat tataaacaac 9661 cctgtaaaaa tttcatcctt tctcctagct actagagcta ctttcctaac cgctgcctac 9721 agattccgaa taataacatt ctgcttcaac aaaaaaacaa aagaaaacgc atcaaatcca 9781 ataaaagaag aaaacccatc actttactta ccccttactc gtctcgcaac agggactata 9841 ctttacgggt gattcctctc aaaatgacta ttcaaaatac cccctttatt cccattaaca 9901 attgttaaga gcacccccct tatagttaca atactaggag cgatcttagc cgctacaata 9961 atattatcca taaaaaacaa gataaaaata accttcttca caaagacctg attttttaaa 10021 aaaataaccc atattattac caaaacccta acatccaaaa tagccctaat aatgtcaacc 10081 cggacacttg accgaggctg aaatgaacta ataggggggc aaggagtgtt cttagcgaaa 10141 aagaccgcag cccaatcctc aaaaaccgct caaacagggt atataaagca ataccttctt 10201 tcaatattta taatttctat ttctatcctt ctccttacca gaatataaaa ggcgatgagt 10261 attataaagc acgtaaagaa acttcagaaa aactaaaaga aataaccaaa gcaactacca 10321 aaacaactaa aagagcaagg ccccctatta acaagtaaaa accaccaaaa ctatataact 10381 cacctagact agaaagcccc tggaatccaa ctaaatcccc cataactctc aactccaaaa 10441 aatcctcaaa aataaaaaga actcaaaaac acatcagcaa aaaaagaact atgacctccc 10501 caagttttct tactacaggg aaccggtcag cagagagtgc actagaataa ataaatacta 10561 ccagcatacc ccccatataa attaaaagta acagcaaagc taaaaaagaa accccacaaa 10621 accctaaaat aacacaacca aataaagagc ttagaaccaa acccaaagca gcataataag 10681 gagacaaact ataaaaaacc atagttctgc ctaacaacaa aaagaccata aataaataaa 10741 ataccattta tataaatgac cagccctatt cgaaagagac accccctatt ccgaatcgtc 10801 aacagcagat tagttgacct cccatcccca agaaaccttt cagtatgatg aaaatttggg 10861 tccctactag gactatgtct aataatacaa atcctaaccg gactgttcct ctccatgcat 10921 tacacagccg acataagact agccttttct tccgttagtc acatttgccg agacgttaaa 10981 aaaggatgac ttctacggaa agttcacgcc aaaacaggct cattcttctt catatgcatt 11041 tactgccaca taggtcgagg tatctactat gggtcttatg ttaatcaaga aacatgaaaa 11101 acaggagtta tactcttcct aataacaatg ataactgcat tcgtagggta cgttctaccc 11161 tgaggacaaa tgtccttctg agcagccacc gtaatcacca atcttctttc agcaataccc 11221 tatataggta aagaattagt acaatgagta tggggaggat tctcagtaga caaagcaaca 11281 ttatcacgat ttttctcctt tcacttccta ttccccttca taatcgcagc tttatcagtt 11341 atacacctct tattcctcca ccaaacaggg tccaacaacc caacaggtct taatagtaaa 11401 atagacaaga ctccattcca cacatatttc tccaccaagg atatagcagg atttatcctt 11461 ttaattgcag gaatccttac attagccctc ctagccccta cagcgctaaa agaccctgaa 11521 aactttatac ctgccaaccc tttaataacc cccacccaca tacaaccaga atgatacttc 11581 ctctttgcat atgcaattct ccgatccatc cccaaaaagc taggaggggt aatagcatta 11641 gtagcagcag ttctcatatg atttatcatc ccattagtac acacatcatg aaaccaatca 11701 tcaacattcc ggcccctcac ccaaataaca ttttgggtac ttatagcaac attcattatc 11761 ctaacttgaa tagggagaca accagtagaa gaacctttta taattatagg acaagtagca 11821 tcagcactat acttctcaat attcattatc ttcttccctt tcgtagcaac actagaaaaa 11881 accatcataa agatatatta aagtagctta atgaaaaagc ttggcgttga aaacaccaga 11941 ccaaaggtta aactcctttc tttagtaaaa gtttggttct agcttaaaat ttaactctgt 12001 tttggctacc acatgtaagt ttatcaacaa accagcaaaa attccaacaa acttaacaaa 12061 aatttgtttg aaaatagaaa agttcccaaa cctacctaac caaacaattg cgaccctcag 12121 tgtttaacct tatacaatct aagaaactag gatatagcca aaaactaaaa aggcggtaaa 12181 taacgtgcca gcaaccgcgg ttacacgtta gcctcaaatt aaataactcc ggaagacaaa 12241 agaaaactaa aaaattttat agaaaaagaa cagcagtaac aagcttaaaa aaacctaata 12301 taaaatatgt ttctcctaaa aaagaaaaga aataaactgg gattagaaac cccactatac 12361 ttttccccct aaaaacacca gagtattata aatctaaaaa ttgaaactta aagaacttgg 12421 cggttttcta aacctttttg gaggagcttg tcatctaatt gataccccac aagaaacctc 12481 accagttttc gaaacagcct gtataccatc gtcgccagct taccttaaag aacgtaagca 12541 aaaagaaata attccaaacg ccagatcaag gtgcagccaa taaactgggg atagatgagc 12601 taccctaatt tccaaccaga ggattttatc ctgaaaaaga taaaggaaaa aggattcaac 12661 agtaattccc taaagaaaca taaaaatg