LOCUS AY172335 16299 bp DNA circular ROD 09-MAR-2004 DEFINITION Mus musculus strain C57BL/6J mitochondrion, complete genome. ACCESSION AY172335 VERSION AY172335.1 GI:33115104 KEYWORDS . SOURCE mitochondrion Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (bases 1 to 16299) AUTHORS Bayona-Bafaluy,M.P., Acin-Perez,R., Mullikin,J.C., Park,J.S., Moreno-Loshuertos,R., Hu,P., Perez-Martos,A., Fernandez-Silva,P., Bai,Y. and Enriquez,J.A. TITLE Revisiting the mouse mitochondrial DNA sequence JOURNAL Nucleic Acids Res. 31 (18), 5349-5355 (2003) PUBMED 12954771 REFERENCE 2 (bases 1 to 16299) AUTHORS Mullikin,J.C. and Enriquez,J.A. TITLE Direct Submission JOURNAL Submitted (04-NOV-2002) Bioquimica y Biologia Molecular y Celular, Universidad de Zaragoza, Miguel Servet, 177, Zaragoza 50013, Espana FEATURES Location/Qualifiers source 1..16299 /organism="Mus musculus" /organelle="mitochondrion" /mol_type="genomic DNA" /strain="C57BL/6J" /db_xref="taxon:10090" tRNA 1..68 /product="tRNA-Phe" /note="annotated according to Bibb M.J., et. al. (1985) Cell 26:167-180" /anticodon=(pos:33..35,aa:Phe) /evidence=not_experimental rRNA 70..1024 /product="12S ribosomal RNA" /note="annotated according to Bibb M.J., et. al. (1985) Cell 26:167-180" /evidence=not_experimental tRNA 1025..1093 /product="tRNA-Val" /note="annotated according to Bibb M.J., et. al. (1985) Cell 26:167-180" /anticodon=(pos:1057..1059,aa:Val) /evidence=not_experimental rRNA 1094..2675 /product="16S ribosomal RNA" /note="annotated according to Bibb M.J., et. al. (1985) Cell 26:167-180" /evidence=not_experimental variation 2256 /note="compared to strains SAMP1 and SAMP8" /replace="c" tRNA 2676..2750 /product="tRNA-Leu" /note="codons recognized: UUR; annotated according to Bibb M.J., et. al. (1985) Cell 26:167-180" /anticodon=(pos:2711..2713,aa:Leu) /evidence=not_experimental gene 2751..3707 /gene="ND1" CDS 2751..3707 /gene="ND1" /EC_number="1.6.5.3" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 1" /protein_id="AAN85122.1" /db_xref="GI:33115105" /translation="MFFINILTLLVPILIAMAFLTLVERKILGYMQLRKGPNIVGPYG ILQPFADAMKLFMKEPMRPLTTSMSLFIIAPTLSLTLALSLWVPLPMPHPLINLNLGI LFILATSSLSVYSILWSGWASNSKYSLFGALRAVAQTISYEVTMAIILLSVLLMNGSY SLQTLITTQEHMWLLLPAWPMAMMWFISTLAETNRAPFDLTEGESELVSGFNVEYAAG PFALFFMAEYTNIILMNALTTIIFLGPLYYINLPELYSTNFMMEALLLSSTFLWIRAS YPRFRYDQLMHLLWKNFLPLTLALCMWHISLPIFTAGVPPYM" tRNA 3706..3774 /product="tRNA-Ile" /note="annotated according to Bibb M.J., et. al. (1985) Cell 26:167-180" /anticodon=(pos:3735..3737,aa:Ile) /evidence=not_experimental tRNA complement(3772..3842) /product="tRNA-Gln" /note="annotated according to Bibb M.J., et. al. (1985) Cell 26:167-180" /anticodon=(pos:3808..3810,aa:Gln) /evidence=not_experimental tRNA 3845..3913 /product="tRNA-Met" /note="annotated according to Bibb M.J., et. al. (1985) Cell 26:167-180" /anticodon=(pos:3875..3877,aa:Met) /evidence=not_experimental gene 3914..4951 /gene="ND2" CDS 3914..4951 /gene="ND2" /EC_number="1.6.5.3" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 2" /protein_id="AAN85123.1" /db_xref="GI:33115106" /translation="MNPITLAIIYFTIFLGPVITMSSTNLMLMWVGLEFSLLAIIPML INKKNPRSTEAATKYFVTQATASMIILLAIVLNYKQLGTWMFQQQTNGLILNMTLMAL SMKLGLAPFHFWLPEVTQGIPLHMGLILLTWQKIAPLSILIQIYPLLNSTIILMLAIT SIFMGAWGGLNQTQMRKIMAYSSIAHMGWMLAILPYNPSLTLLNLMIYIILTAPMFMA LMLNNSMTINSISLLWNKTPAMLTMISLMLLSLGGLPPLTGFLPKWIIITELMKNNCL IMATLMAMMALLNLFFYTRLIYSTSLTMFPTNNNSKMMTHQTKTKPNLMFSTLAIMST MTLPLAPQLIT" tRNA 4950..5016 /product="tRNA-Trp" /note="annotated according to Bibb M.J., et. al. (1985) Cell 26:167-180" /anticodon=(pos:4981..4983,aa:Trp) /evidence=not_experimental tRNA complement(5018..5086) /product="tRNA-Ala" /note="annotated according to Bibb M.J., et. al. (1985) Cell 26:167-180" /anticodon=(pos:5054..5056,aa:Ala) /evidence=not_experimental tRNA complement(5089..5159) /product="tRNA-Asn" /note="annotated according to Bibb M.J., et. al. (1985) Cell 26:167-180" /anticodon=(pos:5126..5128,aa:Asn) /evidence=not_experimental rep_origin 5160..5191 /note="L-strand origin of replication" /direction=right tRNA complement(5192..5257) /product="tRNA-Cys" /note="annotated according to Bibb M.J., et. al. (1985) Cell 26:167-180" /anticodon=(pos:5227..5229,aa:Cys) /evidence=not_experimental tRNA complement(5260..5326) /product="tRNA-Tyr" /note="annotated according to Bibb M.J., et. al. (1985) Cell 26:167-180" /anticodon=(pos:5296..5298,aa:Tyr) /evidence=not_experimental gene 5328..6872 /gene="COXI" CDS 5328..6872 /gene="COXI" /EC_number="1.9.3.1" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="cytochrome c oxidase subunit I" /protein_id="AAN85124.1" /db_xref="GI:33115107" /translation="MFINRWLFSTNHKDIGTLYLLFGAWAGMVGTALSILIRAELGQP GALLGDDQIYNVIVTAHAFVMIFFMVMPMMIGGFGNWLVPLMIGAPDMAFPRMNNMSF WLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILG AINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTT FFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGIISHVVTYYSGKKEPFGYMGMVWA MMSIGFLGFIVWAHHMFTVGLDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKW SPAMLWALGFIFLFTVGGLTGIVLSNSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMAG FVHWFPLFSGFTLDDTWAKAHFAIMFVGVNMTFFPQHFLGLSGMPRRYSDYPDAYTTW NTVSSMGSFISLTAVLIMIFMIWEAFASKREVMSVSYASTNLEWLHGCPPPYHTFEEP TYVKVK" tRNA complement(6870..6938) /product="tRNA-Ser" /note="codons recognized: UCN; annotated according to Guan, M.X., et. al. (1998) Mol. Cell. Biol. 18:5868-5879 and Yokogawa,T., et. al. (1991) Nucleic Acids Res. 19:6101-6105" /anticodon=(pos:6906..6908,aa:Ser) /evidence=not_experimental tRNA 6942..7011 /product="tRNA-Asp" /note="annotated according to Bibb M.J., et. al. (1985) Cell 26:167-180" /anticodon=(pos:6973..6975,aa:Asp) /evidence=not_experimental gene 7013..7696 /gene="COXII" CDS 7013..7696 /gene="COXII" /EC_number="1.9.3.1" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="cytochrome c oxidase subunit II" /protein_id="AAN85125.1" /db_xref="GI:33115108" /translation="MAYPFQLGLQDATSPIMEELMNFHDHTLMIVFLISSLVLYIISL MLTTKLTHTSTMDAQEVETIWTILPAVILIMIALPSLRILYMMDEINNPVLTVKTMGH QWYWSYEYTDYEDLCFDSYMIPTNDLKPGELRLLEVDNRVVLPMELPIRMLISSEDVL HSWAVPSLGLKTDAIPGRLNQATVTSNRPGLFYGQCSEICGSNHSFMPIVLEMVPLKY FENWSASMI" tRNA 7700..7764 /product="tRNA-Lys" /note="annotated according to Bibb M.J., et. al. (1985) Cell 26:167-180" /anticodon=(pos:7726..7728,aa:Lys) /evidence=not_experimental gene 7766..7969 /gene="ATP8" CDS 7766..7969 /gene="ATP8" /EC_number="3.6.1.3" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="ATP synthase F0 subunit 8" /protein_id="AAN85126.1" /db_xref="GI:33115109" /translation="MPQLDTSTWFITIISSMITLFILFQLKVSSQTFPLAPSPKSLTT MKVKTPWELKWTKIYLPHSLPQQ" gene 7927..8607 /gene="ATP6" CDS 7927..8607 /gene="ATP6" /EC_number="3.6.1.3" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="ATP synthase F0 subunit 6" /protein_id="AAN85127.1" /db_xref="GI:33115110" /translation="MNENLFASFITPTMMGFPIVVAIIMFPSILFPSSKRLINNRLHS FQHWLVKLIIKQMMLIHTPKGRTWTLMIVSLIMFIGSTNLLGLLPHTFTPTTQLSMNL SMAIPLWAGAVITGFRHKLKSSLAHFLPQGTPISLIPMLIIIETISLFIQPMALAVRL TANITAGHLLMHLIGGATLVLMNISPPTATITFIILLLLTILEFAVALIQAYVFTLLV SLYLHDNT" gene 8607..9390 /gene="COXIII" CDS 8607..9390 /gene="COXIII" /EC_number="1.9.3.1" /function="oxidative phosphorylation" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:9390,aa:TERM) /transl_table=2 /product="cytochrome c oxidase subunit III" /protein_id="AAN85128.1" /db_xref="GI:33115111" /translation="MTHQTHAYHMVNPSPWPLTGAFSALLLTSGLVMWFHYNSITLLT LGLLTNILTMYQWWRDVIREGTYQGHHTPIVQKGLRYGMILFIVSEVFFFAGFFWAFY HSSLVPTHDLGGCWPPTGISPLNPLEVPLLNTSVLLASGVSITWAHHSLMEGKRNHMN QALLITIMLGLYFTILQASEYFETSFSISDGIYGSTFFMATGFHGLHVIIGSTFLIVC LLRQLKFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS" variation 9348 /gene="COXIII" /note="compared to strains C3H/He, Balb/cJ, A/J and NOD/LtJ" /replace="a" tRNA 9391..9458 /product="tRNA-Gly" /note="annotated according to Bibb M.J., et. al. (1985) Cell 26:167-180" /anticodon=(pos:9421..9423,aa:Gly) /evidence=not_experimental gene 9459..9806 /gene="ND3" CDS 9459..9806 /gene="ND3" /EC_number="1.6.5.3" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 3" /protein_id="AAN85129.1" /db_xref="GI:33115112" /translation="MNLYTVIFINILLSLTLILVAFWLPQMNLYSEKANPYECGFDPT SSARLPFSMKFFLVAITFLLFDLEIALLLPLPWAIQTIKTSTMMIMAFILVTILSLGL AYEWTQKGLEWTE" variation 9461 /gene="ND3" /note="compared to other inbred strains" /replace="c" tRNA 9808..9875 /product="tRNA-Arg" /note="annotated according to Bibb M.J., et. al. (1985) Cell 26:167-180" /anticodon=(pos:9838..9840,aa:Arg) /evidence=not_experimental misc_feature 9821..9830 /note="polymorphic region" gene 9877..10173 /gene="ND4L" CDS 9877..10173 /gene="ND4L" /EC_number="1.6.5.3" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 4L" /protein_id="AAN85130.1" /db_xref="GI:33115113" /translation="MPSTFFNLTMAFSLSLLGTLMFRSHLMSTLLCLEGMVLSLFIMT SVTSLNSNSMSSMPIPITILVFAACEAAVGLALLVKVSNTYGTDYVQNLNLLQC" gene 10167..11544 /gene="ND4" CDS 10167..11544 /gene="ND4" /EC_number="1.6.5.3" /function="oxidative phosphorylation" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:11544,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 4" /protein_id="AAN85131.1" /db_xref="GI:33115114" /translation="MLKIILPSLMLLPLTWLSSPKKTWTNVTSYSFLISLTSLTLLWQ TDENYKNFSNMFSSDPLSTPLIILTAWLLPLMLMASQNHLKKDNNVLQKLYISMLISL QILLIMTFSATELIMFYILFEATLIPTLIIITRWGNQTERLNAGIYFLFYTLIGSIPL LIALILIQNHVGTLNLMILSFTTHTLDASWSNNLLWLACMMAFLIKMPLYGVHLWLPK AHVEAPIAGSMILAAILLKLGSYGMIRISIILDPLTKYMAYPFILLSLWGMIMTSSIC LRQTDLKSLIAYSSVSHMALVIASIMIQTPWSFMGATMLMIAHGLTSSLLFCLANSNY ERIHSRTMIMARGLQMVFPLMATWWLMASLANLALPPSINLMGELFITMSLFSWSNFT IILMGINIIITGMYSMYMIITTQRGKLTNHMINLQPSHTRELTLMALHMIPLILLTTS PKLITGLTM" variation 10847 /gene="ND4" /note="compared to strain SAMP8" /replace="a" variation 11181 /gene="ND4" /note="compared to strains SAMP1 and SAMP8" /replace="g" tRNA 11545..11612 /product="tRNA-His" /note="annotated according to Bibb M.J., et. al. (1985) Cell 26:167-180" /anticodon=(pos:11575..11577,aa:His) /evidence=not_experimental tRNA 11613..11671 /product="tRNA-Ser" /note="codons recognized: AGY; annotated according to Bibb M.J., et. al. (1985) Cell 26:167-180" /anticodon=(pos:11632..11634,aa:Ser) /evidence=not_experimental tRNA 11672..11742 /product="tRNA-Leu" /note="codons recognized: CUN; annotated according to Bibb M.J., et. al. (1985) Cell 26:167-180" /anticodon=(pos:11703..11705,aa:Leu) /evidence=not_experimental gene 11742..13565 /gene="ND5" CDS 11742..13565 /gene="ND5" /EC_number="1.6.5.3" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 5" /protein_id="AAN85132.1" /db_xref="GI:33115115" /translation="MNIFTTSILLIFILLLSPILISMSNLIKHINFPLYTTTSIKFSF IISLLPLLMFFHNNMEYMITTWHWVTMNSMELKMSFKTDFFSILFTSVALFVTWSIMQ FSSWYMHSDPNINRFIKYLTLFLITMLILTSANNMFQLFIGWEGVGIMSFLLIGWWYG RTDANTAALQAILYNRIGDIGFILAMVWFSLNMNSWELQQIMFSNNNDNLIPLMGLLI AATGKSAQFGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLVRFHPLTTNNNFILTT MLCLGALTTLFTAICALTQNDIKKIIAFSTSSQLGLMMVTLGMNQPHLAFLHICTHAF FKAMLFMCSGSIIHSLADEQDIRKMGNITKIMPFTSSCLVIGSLALTGMPFLTGFYSK DLIIEAINTCNTNAWALLITLIATSMTAMYSMRIIYFVTMTKPRFPPLISINENDPDL MNPIKRLAFGSIFAGFVISYNIPPTSIPVLTMPWFLKTTALIISVLGFLIALELNNLT MKLSMNKANPYSSFSTLLGFFPSIIHRITPMKSLNLSLKTSLTLLDLIWLEKTIPKST STLHTNMTTLTTNQKGLIKLYFMSFLINIILIIILYSINLE" variation 13052 /gene="ND5" /note="compared to strains SAMR1, SAMP1 and SAMP8" /replace="c" gene complement(13552..14070) /gene="ND6" CDS complement(13552..14070) /gene="ND6" /EC_number="1.6.5.3" /function="oxidative phosphorylation" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 6" /protein_id="AAN85133.1" /db_xref="GI:33115116" /translation="MNNYIFVLSSLFLVGCLGLALKPSPIYGGLGLIVSGFVGCLMVL GFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPETWGSNWLILGFLVLGVIMEVFL ICVLNYYDEVGVINLDGLGDWLMYEVDDVGVMLEGGIGVAAMYSCATWMMVVAGWSLF AGIFIIIEITRD" tRNA complement(14071..14139) /product="tRNA-Glu" /note="annotated according to Bibb M.J., et. al. (1985) Cell 26:167-180" /anticodon=(pos:14107..14109,aa:Glu) /evidence=not_experimental gene 14145..15288 /gene="CYTB" CDS 14145..15288 /gene="CYTB" /EC_number="1.10.2.2" /function="oxidative phosphorylation" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:15288,aa:TERM) /transl_table=2 /product="cytochrome b" /protein_id="AAN85134.1" /db_xref="GI:33115117" /translation="MTNMRKTHPLFKIINHSFIDLPAPSNISSWWNFGSLLGVCLMVQ IITGLFLAMHYTSDTMTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGL YYGSYTFMETWNIGVLLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTL VEWIWGGFSVDKATLTRFFAFHFILPFIIAALAIVHLLFLHETGSNNPTGLNSDADKI PFHPYYTIKDILGILIMFLILMTLVLFFPDMLGDPDNYMPANPLNTPPHIKPEWYFLF AYAILRSIPNKLGGVLALILSILILALMPFLHTSKQRSLMFRPITQILYWILVANLLI LTWIGGQPVEHPFIIIGQLASISYFSIILILMPISGIIEDKMLKLYP" tRNA 15289..15355 /product="tRNA-Thr" /note="annotated according to Bibb M.J., et. al. (1985) Cell 26:167-180" /anticodon=(pos:15319..15321,aa:Thr) /evidence=not_experimental tRNA complement(15356..15422) /product="tRNA-Pro" /note="annotated according to Bibb M.J., et. al. (1985) Cell 26:167-180" /anticodon=(pos:15390..15392,aa:Pro) /evidence=not_experimental D-loop 15423..16299 misc_feature 15451..15509 /note="ETAS1; extended termination associated sequence 1; annotated according to Sbisa E., et. al. (1997) Gene 205:125-140" misc_feature 15515..15558 /note="ETAS2; extended termination associated sequence 2; annotated according to Sbisa E., et. al. (1997) Gene 205:125-140" misc_feature 16035..16058 /note="CSB1; conserved sequencing block 1; annotated according to Sbisa E., et. al. (1997) Gene 205:125-140" misc_feature 16089..16104 /note="CSB2; conserved sequencing block 2; annotated according to Sbisa E., et. al. (1997) Gene 205:125-140" misc_feature 16114..16131 /note="CSB3; conserved sequencing block 3; annotated according to Sbisa E., et. al. (1997) Gene 205:125-140" ORIGIN 1 gttaatgtag cttaataaca aagcaaagca ctgaaaatgc ttagatggat aattgtatcc 61 cataaacaca aaggtttggt cctggcctta taattaatta gaggtaaaat tacacatgca 121 aacctccata gaccggtgta aaatccctta aacatttact taaaatttaa ggagagggta 181 tcaagcacat taaaatagct taagacacct tgcctagcca cacccccacg ggactcagca 241 gtgataaata ttaagcaata aacgaaagtt tgactaagtt atacctctta gggttggtaa 301 atttcgtgcc agccaccgcg gtcatacgat taacccaaac taattatctt cggcgtaaaa 361 cgtgtcaact ataaataaat aaatagaatt aaaatccaac ttatatgtga aaattcattg 421 ttaggaccta aactcaataa cgaaagtaat tctagtcatt tataatacac gacagctaag 481 acccaaactg ggattagata ccccactatg cttagccata aacctaaata attaaattta 541 acaaaactat ttgccagaga actactagcc atagcttaaa actcaaagga cttggcggta 601 ctttatatcc atctagagga gcctgttcta taatcgataa accccgctct acctcaccat 661 ctcttgctaa ttcagcctat ataccgccat cttcagcaaa ccctaaaaag gtattaaagt 721 aagcaaaaga atcaaacata aaaacgttag gtcaaggtgt agccaatgaa atgggaagaa 781 atgggctaca ttttcttata aaagaacatt actataccct ttatgaaact aaaggactaa 841 ggaggattta gtagtaaatt aagaatagag agcttaattg aattgagcaa tgaagtacgc 901 acacaccgcc cgtcaccctc ctcaaattaa attaaactta acataattaa tttctagaca 961 tccgtttatg agaggagata agtcgtaaca aggtaagcat actggaaagt gtgcttggaa 1021 taatcatagt gtagcttaat attaaagcat ctggcctaca cccagaagat ttcatgacca 1081 atgaacactc tgaactaatc ctagccctag ccctacacaa atataattat actattatat 1141 aaatcaaaac atttatccta ctaaaagtat tggagaaaga aattcgtaca tctaggagct 1201 atagaactag taccgcaagg gaaagatgaa agactaatta aaagtaagaa caagcaaaga 1261 ttaaaccttg taccttttgc ataatgaact aactagaaaa cttctaacta aaagaattac 1321 agctagaaac cccgaaacca aacgagctac ctaaaaacaa ttttatgaat caactcgtct 1381 atgtggcaaa atagtgagaa gatttttagg tagaggtgaa aagcctaacg agcttggtga 1441 tagctggtta cccaaaaaat gaatttaagt tcaattttaa acttgctaaa aaaacaacaa 1501 aatcaaaaag taagtttaga ttatagccaa aagagggaca gctcttctgg aacggaaaaa 1561 acctttaata gtgaataatt aacaaaacag cttttaacca ttgtaggcct aaaagcagcc 1621 accaataaag aaagcgttca agctcaacat aaaatttcaa ttaattccat aatttacacc 1681 aacttcctaa acttaaaatt gggttaatct ataactttat agatgcaaca ctgttagtat 1741 gagtaacaag aattccaatt ctccaggcat acgcgtataa caactcggat aaccattgtt 1801 agttaatcag actataggca ataatcacac tataaataat ccacctataa cttctctgtt 1861 aacccaacac cggaatgcct aaaggaaaga tccaaaaaga taaaaggaac tcggcaaaca 1921 agaaccccgc ctgtttacca aaaacatcac ctctagcatt acaagtatta gaggcactgc 1981 ctgcccagtg actaaagttt aacggccgcg gtatcctgac cgtgcaaagg tagcataatc 2041 acttgttcct taattaggga ctagcatgaa cggctaaacg agggtccaac tgtctcttat 2101 ctttaatcag tgaaattgac ctttcagtga agaggctgaa atataataat aagacgagaa 2161 gaccctatgg agcttaaatt atataactta tctatttaat ttattaaacc taatggccca 2221 aaaactatag tataagtttg aaatttcggt tggggtgacc tcggagaata aaaaatcctc 2281 cgaatgatta taacctagac ttacaagtca aagtaaaatc aacatatctt attgacccag 2341 atatattttg atcaacggac caagttaccc tagggataac agcgcaatcc tatttaagag 2401 ttcatatcga caattagggt ttacgacctc gatgttggat caggacatcc caatggtgta 2461 gaagctatta atggttcgtt tgttcaacga ttaaagtcct acgtgatctg agttcagacc 2521 ggagcaatcc aggtcggttt ctatctattt acgatttctc ccagtacgaa aggacaagag 2581 aaatagagcc accttacaaa taagcgctct caacttaatt tatgaataaa atctaaataa 2641 aatatatacg tacaccctct aacctagaga aggttattag ggtggcagag ccaggaaatt 2701 gcgtaagact taaaaccttg ttcccagagg ttcaaatcct ctccctaata gtgttcttta 2761 ttaatatcct aacactcctc gtccccattc taatcgccat agccttccta acattagtag 2821 aacgcaaaat cttagggtac atacaactac gaaaaggccc taacattgtt ggtccatacg 2881 gcattttaca accatttgca gacgccataa aattatttat aaaagaacca atacgccctt 2941 taacaacctc tatatcctta tttattattg cacctaccct atcactcaca ctagcattaa 3001 gtctatgagt tcccctacca ataccacacc cattaattaa tttaaaccta gggattttat 3061 ttattttagc aacatctagc ctatcagttt actccattct atgatcagga tgagcctcaa 3121 actccaaata ctcactattc ggagctttac gagccgtagc ccaaacaatt tcatatgaag 3181 taaccatagc tattatcctt ttatcagttc tattaataaa tggatcctac tctctacaaa 3241 cacttattac aacccaagaa cacatatgat tacttctgcc agcctgaccc atagccataa 3301 tatgatttat ctcaacccta gcagaaacaa accgggcccc cttcgacctg acagaaggag 3361 aatcagaatt agtatcaggg tttaacgtag aatacgcagc cggcccattc gcgttattct 3421 ttatagcaga gtacactaac attattctaa taaacgccct aacaactatt atcttcctag 3481 gacccctata ctatatcaat ttaccagaac tctactcaac taacttcata atagaagctc 3541 tactactatc atcaacattc ctatggatcc gagcatctta tccacgcttc cgttacgatc 3601 aacttataca tcttctatga aaaaactttc tacccctaac actagcatta tgtatgtgac 3661 atatttcttt accaattttt acagcgggag taccaccata catatagaaa tatgtctgat 3721 aaaagaatta ctttgataga gtaaattata gaggttcaag ccctcttatt tctaggacaa 3781 taggaattga acctacactt aagaattcaa aattctccgt gctacctaaa caccttatcc 3841 taatagtaag gtcagctaat taagctatcg ggcccatacc ccgaaaacgt tggtttaaat 3901 ccttcccgta ctaataaatc ctatcaccct tgccatcatc tacttcacaa tcttcttagg 3961 tcctgtaatc acaatatcca gcaccaacct aatactaata tgagtaggcc tggaattcag 4021 cctactagca attatcccca tactaatcaa caaaaaaaac ccacgatcaa ctgaagcagc 4081 aacaaaatac ttcgtcacac aagcaacagc ctcaataatt atcctcctgg ccatcgtact 4141 caactataaa caactaggaa catgaatatt tcaacaacaa acaaacggtc ttatccttaa 4201 cataacatta atagccctat ccataaaact aggcctcgcc ccattccact tctgattacc 4261 agaagtaact caagggatcc cactgcacat aggacttatt cttcttacat gacaaaaaat 4321 tgctccccta tcaattttaa ttcaaattta cccgctactc aactctacta tcattttaat 4381 actagcaatt acttctattt tcataggggc atgaggagga cttaaccaaa cacaaatacg 4441 aaaaattata gcctattcat caattgccca cataggatga atattagcaa ttcttcctta 4501 caacccatcc ctcactctac tcaacctcat aatctatatt attcttacag cccctatatt 4561 catagcactt atactaaata actctataac catcaactca atctcacttc tatgaaataa 4621 aactccagca atactaacta taatctcact gatattacta tccctaggag gccttccacc 4681 actaacagga ttcttaccaa aatgaattat catcacagaa cttataaaaa acaactgtct 4741 aattatagca acactcatag caataatagc tctactaaac ctattctttt atactcgcct 4801 aatttattcc acttcactaa caatatttcc aaccaacaat aactcaaaaa taataactca 4861 ccaaacaaaa actaaaccca acctaatatt ttccacccta gctatcataa gcacaataac 4921 cctaccccta gccccccaac taattaccta gaagtttagg atatactagt ccgcgagcct 4981 tcaaagccct aagaaaacac acaagtttaa cttctgataa ggactgtaag acttcatcct 5041 acatctattg aatgcaaatc aattgcttta attaagctaa gacctcaact agattggcag 5101 gaattaaacc tacgaaaatt tagttaacag ctaaataccc tattactggc ttcaatctac 5161 ttctaccgcc gaaaaaaaaa aatggcggta gaagtcttag tagagatttc tctacacctt 5221 cgaatttgca attcgacatg aatatcacct taagacctct ggtaaaaaga ggatttaaac 5281 ctctgtgttt agatttacag tctaatgctt actcagccat tttacctatg ttcattaatc 5341 gttgattatt ctcaaccaat cacaaagata tcggaaccct ctatctacta ttcggagcct 5401 gagcgggaat agtgggtact gcactaagta ttttaattcg agcagaatta ggtcaaccag 5461 gtgcactttt aggagatgac caaatttaca atgttatcgt aactgcccat gcttttgtta 5521 taattttctt catagtaata ccaataataa ttggaggctt tggaaactga cttgtcccac 5581 taataatcgg agccccagat atagcattcc cacgaataaa taatataagt ttttgactcc 5641 taccaccatc atttctcctt ctcctagcat catcaatagt agaagcagga gcaggaacag 5701 gatgaacagt ctacccacct ctagccggaa atctagccca tgcaggagca tcagtagacc 5761 taacaatttt ctcccttcat ttagctggag tgtcatctat tttaggtgca attaatttta 5821 ttaccactat tatcaacatg aaacccccag ccataacaca gtatcaaact ccactatttg 5881 tctgatccgt acttattaca gccgtactgc tcctattatc actaccagtg ctagccgcag 5941 gcattactat actactaaca gaccgcaacc taaacacaac tttctttgat cccgctggag 6001 gaggggaccc aattctctac cagcatctgt tctgattctt tgggcaccca gaagtttata 6061 ttcttatcct cccaggattt ggaattattt cacatgtagt tacttactac tccggaaaaa 6121 aagaaccttt cggctatata ggaatagtat gagcaataat gtctattggc tttctaggct 6181 ttattgtatg agcccaccac atattcacag taggattaga tgtagacaca cgagcttact 6241 ttacatcagc cactataatt atcgcaattc ctaccggtgt caaagtattt agctgacttg 6301 caaccctaca cggaggtaat attaaatgat ctccagctat actatgagcc ttaggcttta 6361 ttttcttatt tacagttggt ggtctaaccg gaattgtttt atccaactca tcccttgaca 6421 tcgtgcttca cgatacatac tatgtagtag cccatttcca ctatgttcta tcaatgggag 6481 cagtgtttgc tatcatagca ggatttgttc actgattccc attattttca ggcttcaccc 6541 tagatgacac atgagcaaaa gcccacttcg ccatcatatt cgtaggagta aacataacat 6601 tcttccctca acatttcctg ggcctttcag gaataccacg acgctactca gactacccag 6661 atgcttacac cacatgaaac actgtctctt ctataggatc atttatttca ctaacagctg 6721 ttctcatcat gatctttata atttgagagg cctttgcttc aaaacgagaa gtaatatcag 6781 tatcgtatgc ttcaacaaat ttagaatgac ttcatggctg ccctccacca tatcacacat 6841 tcgaggaacc aacctatgta aaagtaaaat aagaaaggaa ggaatcgaac cccctaaaat 6901 tggtttcaag ccaatctcat atcctatatg tctttctcaa taagatatta gtaaaatcaa 6961 ttacataact ttgtcaaagt taaattatag atcaataatc tatatatctt atatggccta 7021 cccattccaa cttggtctac aagacgccac atcccctatt atagaagagc taataaattt 7081 ccatgatcac acactaataa ttgttttcct aattagctcc ttagtcctct atatcatctc 7141 gctaatatta acaacaaaac taacacatac aagcacaata gatgcacaag aagttgaaac 7201 catttgaact attctaccag ctgtaatcct tatcataatt gctctcccct ctctacgcat 7261 tctatatata atagacgaaa tcaacaaccc cgtattaacc gttaaaacca tagggcacca 7321 atgatactga agctacgaat atactgacta tgaagaccta tgctttgatt catatataat 7381 cccaacaaac gacctaaaac ctggtgaact acgactgcta gaagttgata accgagtcgt 7441 tctgccaata gaacttccaa tccgtatatt aatttcatct gaagacgtcc tccactcatg 7501 agcagtcccc tccctaggac ttaaaactga tgccatccca ggccgactaa atcaagcaac 7561 agtaacatca aaccgaccag ggttattcta tggccaatgc tctgaaattt gtggatctaa 7621 ccatagcttt atgcccattg tcctagaaat ggttccacta aaatatttcg aaaactgatc 7681 tgcttcaata atttaatttc actatgaagc taagagcgtt aaccttttaa gttaaagtta 7741 gagaccttaa aatctccata gtgatatgcc acaactagat acatcaacat gatttatcac 7801 aattatctca tcaataatta ccctatttat cttatttcaa ctaaaagtct catcacaaac 7861 attcccactg gcaccttcac caaaatcact aacaaccata aaagtaaaaa ccccttgaga 7921 attaaaatga acgaaaatct atttgcctca ttcattaccc caacaataat aggattccca 7981 atcgttgtag ccatcattat atttccttca atcctattcc catcctcaaa acgcctaatc 8041 aacaaccgtc tccattcttt ccaacactga ctagttaaac ttattatcaa acaaataatg 8101 ctaatccaca caccaaaagg acgaacatga accctaataa ttgtttccct aatcatattt 8161 attggatcaa caaatctcct aggcctttta ccacatacat ttacacctac tacccaacta 8221 tccataaatc taagtatagc cattccacta tgagctggag ccgtaattac aggcttccga 8281 cacaaactaa aaagctcact tgcccacttc cttccacaag gaactccaat ttcactaatt 8341 ccaatactta ttattattga aacaattagc ctatttattc aaccaatggc attagcagtc 8401 cggcttacag ctaacattac tgcaggacac ttattaatac acctaatcgg aggagctact 8461 ctagtattaa taaatattag cccaccaaca gctaccatta catttattat tttacttcta 8521 ctcacaattc tagaatttgc agtagcatta attcaagcct acgtattcac cctcctagta 8581 agcctatatc tacatgataa tacataatga cccaccaaac tcatgcatat cacatagtta 8641 atccaagtcc atgaccatta actggagcct tttcagccct ccttctaaca tcaggtctag 8701 taatatgatt tcactataat tcaattacac tattaaccct tggcctactc accaatatcc 8761 tcacaatata tcaatgatga cgagacgtaa ttcgtgaagg aacctaccaa ggccaccaca 8821 ctcctattgt acaaaaagga ctacgatatg gtataattct attcatcgtc tcggaagtat 8881 ttttctttgc aggattcttc tgagcgttct atcattctag cctcgtacca acacatgatc 8941 taggaggctg ctgacctcca acaggaattt caccacttaa ccctctagaa gtcccactac 9001 ttaatacttc agtacttcta gcatcaggtg tttcaattac atgagctcat catagcctta 9061 tagaaggtaa acgaaaccac ataaatcaag ccctactaat taccattata ctaggacttt 9121 acttcaccat cctccaagct tcagaatact ttgaaacatc attctccatt tcagatggta 9181 tctatggttc tacattcttc atggctactg gattccatgg actccatgta attattggat 9241 caacattcct tattgtttgc ctactacgac aactaaaatt tcacttcaca tcaaaacatc 9301 acttcggatt tgaagccgca gcatgatact gacattttgt agacgtagtc tgacttttcc 9361 tatacgtctc catttattga tgaggatctt actcccttag tataattaat ataactgact 9421 tccaattagt agattctgaa taaacccaga agagagtaat taacctgtac actgttatct 9481 tcattaatat tttattatcc ctaacgctaa ttctagttgc attctgactc ccccaaataa 9541 atctgtactc agaaaaagca aatccatatg aatgcggatt cgaccctaca agctctgcac 9601 gtctaccatt ctcaataaaa tttttcttgg tagcaattac atttctatta tttgacctag 9661 aaattgctct tctacttcca ctaccatgag caattcaaac aattaaaacc tctactataa 9721 taattatagc ctttattcta gtcacaattc tatctctagg cctagcatat gaatgaacac 9781 aaaaaggatt agaatgaaca gagtaaatgg taattagttt aaaaaaaatt aatgatttcg 9841 actcattaga ttatgatgat gttcataatt accaatatgc catctacctt cttcaacctc 9901 accatagcct tctcactatc acttctaggg acacttatat ttcgctctca cctaatatcc 9961 acattactat gcctggaagg catagtatta tccttattta ttataacttc agtaacttcc 10021 ctaaactcca actccataag ctccatacca atccccatca ccatcttagt tttcgcagcc 10081 tgcgaagcag ctgtaggact agccctacta gtaaaagttt caaacacgta cggaacagat 10141 tacgtccaaa atctcaacct actacaatgc taaaaattat tcttccctca ctaatgctac 10201 taccactaac ctgactatca agccctaaaa aaacctgaac aaacgtaacc tcatatagtt 10261 ttctaattag tttaaccagc ctaacacttc tatgacaaac cgacgaaaat tataaaaact 10321 tttcaaatat attctcctca gaccccctat ccacaccatt aattatttta acagcctgat 10381 tactgccact aatattaata gctagccaaa accacctaaa aaaagataat aacgtactac 10441 aaaaactcta catctcaata ctaatcagct tacaaattct cctaatcata accttttcag 10501 caactgaact aattatattt tatattttat ttgaagcaac cttaatccca acacttatta 10561 ttattacccg atgagggaac caaactgaac gcctaaacgc agggatttat ttcctatttt 10621 ataccctaat cggttctatt ccactgctaa ttgccctcat cttaatccaa aaccatgtag 10681 gaaccctaaa cctcataatt ttatcattca caacacacac cttagacgct tcatgatcta 10741 acaacttact atggttggca tgcataatag catttcttat taaaatacca ttatatggag 10801 ttcacctatg actaccaaaa gcccatgttg aagctccaat tgctgggtca ataattctag 10861 cagctattct tctaaaatta ggtagttacg gaataattcg catctccatt attctagacc 10921 cactaacaaa atatatagca taccccttca tccttctctc cctatgagga ataattataa 10981 ctagctcaat ctgcttacgc caaacagatt taaaatcact aatcgcctac tcctcagtta 11041 gccacatagc acttgttatt gcatcaatca taatccaaac tccatgaagc ttcataggag 11101 caacaatact aataatcgca catggcctca catcatcact cctattctgc ctagcaaact 11161 ccaactacga acggatccac agccgtacta taatcatggc ccgaggactt caaatggtct 11221 tcccacttat agccacatga tgactgatag caagtctagc taatctagct ctaccccctt 11281 caatcaatct aataggagaa ttattcatta ccatatcatt attttcttga tcaaacttta 11341 ccattattct tataggaatt aacattatta ttacaggtat atactcaata tacataatta 11401 ttaccaccca acgcggcaaa ctaaccaacc atataattaa cctccaaccc tcacacacac 11461 gagaactaac actaatagcc cttcacataa ttccacttat tcttctaact accagtccaa 11521 aactaattac aggcctgaca atatgtgaat atagtttaca aaaaacatta gactgtgaat 11581 ctgacaacag gaaataaacc tccttattca ccaagaaaga ttgcaagaac tgctaattca 11641 tgcttccatg tttaaaaaca tggctttctt acttttatag gataatagta atccattggt 11701 cttaggaacc aaaaaccttg gtgcaaatcc aaataaaagt aatcaatatt ttcacaacct 11761 caatcttatt aatcttcatt cttctactat ccccaatcct aatttcaata tcaaacctaa 11821 ttaaacacat caacttccca ctgtacacca ccacatcaat caaattctcc ttcattatta 11881 gcctcttacc cctattaata tttttccaca ataatataga atatataatt acaacctggc 11941 actgagtcac cataaattca atagaactta aaataagctt caaaactgac tttttctcta 12001 tcctgtttac atctgtagcc ctttttgtca catgatcaat tatacaattc tcttcatgat 12061 atatacactc agacccaaac atcaatcgat tcattaaata tcttacacta ttcctgatta 12121 ccatgcttat cctcacctca gccaacaaca tatttcaact tttcattggc tgagaagggg 12181 tgggaattat atctttccta ctaattggat gatggtacgg acgaacagac gcaaatactg 12241 cagccctaca agcaatcctc tataaccgca tcggagacat cggattcatt ttagctatag 12301 tttgattttc cctaaacata aactcatgag aacttcaaca gattatattc tccaacaaca 12361 acgacaatct aattccactt ataggcctat taatcgcagc tacaggaaaa tcagcacaat 12421 ttggcctcca cccatgacta ccatcagcaa tagaaggccc tacaccagtt tcagcactac 12481 tacactcaag tacaatagta gttgcaggaa ttttcctact ggtccgattc caccccctca 12541 cgactaataa taactttatt ttaacaacta tactttgcct cggagcccta accacattat 12601 ttacagctat ttgtgctctc acccaaaacg acatcaaaaa aatcattgcc ttctctacat 12661 caagccaact aggcctgata atagtgacgc taggaataaa ccaaccacac ctagcattcc 12721 tacacatctg tacccacgca ttcttcaaag ctatactctt tatatgctct ggctcaatca 12781 ttcatagcct ggcagacgaa caagacatcc gaaaaatagg aaacatcaca aaaatcatac 12841 cattcacatc atcatgccta gtaatcggaa gcctcgccct cacaggaata ccattcctaa 12901 cagggttcta ctcaaaagac ctaattattg aagcaattaa tacctgcaac accaacgcct 12961 gagccctact aattacacta atcgccactt ctataacagc tatgtacagc atacgaatca 13021 tttacttcgt aacaataaca aaaccgcgtt ttccccccct aatctccatt aacgaaaatg 13081 acccagacct cataaaccca atcaaacgcc tagcattcgg aagcatcttt gcaggatttg 13141 tcatctcata taatattcca ccaaccagca ttccagtcct cacaatacca tgatttttaa 13201 aaaccacagc cctaattatt tcagtattag gattcctaat cgcactagaa ctaaacaacc 13261 taaccataaa actatcaata aataaagcaa atccatattc atccttctca actttactgg 13321 ggtttttccc atctattatt caccgcatta cacccataaa atctctcaac ctaagcctaa 13381 aaacatccct aactctccta gacttgatct ggttagaaaa aaccatccca aaatccacct 13441 caactcttca cacaaacata accactttaa caaccaacca aaaaggctta attaaattgt 13501 actttatatc attcctaatt aacatcatct taattattat cttatactca attaatctcg 13561 agtaatctcg ataataataa aaatacccgc aaacaaagat cacccagcta ctaccatcat 13621 tcaagtagca caactatata ttgccgctac cccaatccct ccttccaaca taactccaac 13681 atcatcaacc tcatacatca accaatctcc caaaccatca agattaatta ctccaacttc 13741 atcataataa ttaagcacac aaattaaaaa aacctctata atcaccccca atactaaaaa 13801 acccaaaatt aatcagttag atccccaagt ctctggatat tcctcagtag ctatagcagt 13861 cgtatatcca aacacaacca acatcccccc taaataaatt aaaaaaacta ttaaacctaa 13921 aaacgatcca ccaaacccta aaaccattaa acaaccaaca aacccactaa caattaaacc 13981 taaacctcca taaataggtg aaggctttaa tgctaaccca agacaaccaa ccaaaaataa 14041 tgaacttaaa acaaaaatat aattattcat tatttctaca cagcattcaa ctgcgaccaa 14101 tgacatgaaa aatcatcgtt gtaattcaac tacagaaaca cctaatgaca aacatacgaa 14161 aaacacaccc attatttaaa attat