LOCUS AF346996 16566 bp DNA circular PRI 22-AUG-2003 DEFINITION Homo sapiens mitochondrion, complete genome. ACCESSION AF346996 VERSION AF346996.1 GI:13273018 KEYWORDS . SOURCE human. ORGANISM Mitochondrion Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 16566) AUTHORS Ingman,M., Kaessmann,H., Paabo,S. and Gyllensten,U. TITLE Mitochondrial genome variation and the origin of modern humans JOURNAL Nature 408 (6813), 708-713 (2000) MEDLINE 21012010 PUBMED 11130070 REFERENCE 2 (bases 1 to 16566) AUTHORS Ingman,M., Kaessmann,H., Paabo,S. and Gyllensten,U. TITLE Direct Submission JOURNAL Submitted (09-FEB-2001) Genetics and Pathology, Uppsala University, Rudbeck Laboratory, Dag Hammarsjolds vag 20, Uppsala 751 85, Sweden FEATURES Location/Qualifiers source 1..16566 /organism="Homo sapiens" /organelle="mitochondrion" /db_xref="taxon:9606" /note="from African (Mbenzele) individual" D-loop complement(join(1..576,16025..16566)) tRNA 576..646 /product="tRNA-Phe" rRNA 647..1600 /product="12S ribosomal RNA" tRNA 1601..1669 /product="tRNA-Val" rRNA 1670..3226 /product="16S ribosomal RNA" tRNA 3228..3301 /note="codons recognized: CUN" /product="tRNA-Leu" CDS 3304..4260 /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 1" /protein_id="AAK17636.1" /db_xref="GI:13273019" /translation="MPMANLLLLIVPILIAMAFLMLTERKILGYMQLRKGPNVVGPYG LLQPFADAMKLFTKEPLKPATSTITLYITAPTLALTIALLLWTPLPMPNPLVNLNLGL LFILATSSLAVYSILWSGWASNSNYALIGALRAVAQTISYEVTLAIILLSTLLMSGSF NLSSLITTQEHLWLLLPSWPLAMMWFISTLAETNRTPFDLAEGESELVSGFNIEYAAG PFALFFMAEYTNIIMMNTLTTTIFLGTTYDALSPELYTTYFVTKTLLLTSLFLWIRTA YPRFRYDQLMHLLWKNFLPLTLALLMWYVSMPITISSIPPQT" tRNA 4260..4328 /product="tRNA-Ile" tRNA complement(4326..4397) /product="tRNA-Gln" tRNA 4399..4466 /product="tRNA-Met" CDS 4467..5510 /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 2" /protein_id="AAK17637.1" /db_xref="GI:13273020" /translation="MNPLAQPVIYSTVFAGTLITALSSHWFFTWVGLEMNMLAFIPVL TKKMNPRSTEAAIKYFLTQATASMILLMAILFNNMLSGQWTMTNTTNQYSSLMIMMAM AMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPSLNVSLLLTLSIL SIMAGSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLL LNLNSSTTTLLLSRTWNKLTWLTPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSL IIPTIMATITLLNLYFYLRLIYSTSITLLPMSNNVKMKWQFEHTKPTPFLPTLIALTT LLLPISPFMLMIL" tRNA 5509..5576 /product="tRNA-Trp" tRNA complement(5584..5652) /product="tRNA-Ala" tRNA complement(5654..5726) /product="tRNA-Asn" tRNA complement(5758..5823) /product="tRNA-Cys" tRNA complement(5823..5888) /product="tRNA-Tyr" CDS 5901..7442 /codon_start=1 /transl_table=2 /product="cytochrome c oxidase subunit I" /protein_id="AAK17638.1" /db_xref="GI:13273021" /translation="MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQP GNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSF WLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILG AINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTT FFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWA MMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKW SAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGG FIHWFPLFSGYTLDQTYAKIHFAIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTW NILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLHGCPPPYHTFEEP VYMKS" tRNA complement(7442..7513) /note="codons recognized: AGY" /product="tRNA-Ser" tRNA 7515..7582 /product="tRNA-Asp" CDS 7583..8266 /codon_start=1 /transl_table=2 /product="cytochrome c oxidase subunit II" /protein_id="AAK17639.1" /db_xref="GI:13273022" /translation="MAHAAQVGLQDATSPIMEELITFHDHALMIIFLICFLVLYALFL TLTTKLTNTNISDAQEMETVWTILPAIILVLIALPSLRILYMTDEVNDPSLTIKSIGH QWYWTYEYTDYGGLIFNSYMLPPLFLEPGDLRLLDVDNRVVLPIETPIRMMITSQDVL HSWAVPTLGLKTDAIPGRLNQTTFTATRPGVYYGQCSEICGANHSFMPIVLELIPLKI FEMGPVFTL" tRNA 8292..8361 /product="tRNA-Lys" CDS 8363..8569 /codon_start=1 /transl_table=2 /product="ATP synthase 8" /protein_id="AAK17640.1" /db_xref="GI:13273023" /translation="MPQLNTTVWPTMITPMLLTLFLITQLKMLNTNYHLPPSPKPMKM KNYNKPWEPKWTKICSLHSLPPQS" CDS 8524..9204 /codon_start=1 /transl_table=2 /product="ATP synthase 6" /protein_id="AAK17641.1" /db_xref="GI:13273024" /translation="MNENLFASFIAPTILGLPAAVLIILFPPLLIPTSKYLINNRLIT TQQWLIKLTSKQMMAMHNTKGRTWSLMLVSLIIFIATTNLLGLLPHSFTPTTQLSMNL AMAIPLWAGAVIMGFRSKIKNALAHFLPQGTPTPLIPMLVIIETISLLIQPMALAVRL TANITAGHLLMHLIGSATLAMSTINLPSTLIIFTILILLTILEIAVALIQAYVFTLLV SLYLHDNT" CDS 9204..9984 /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:9984,aa:TERM) /transl_table=2 /product="cytochrome c oxidase subunit III" /protein_id="AAK17642.2" /db_xref="GI:13347060" /translation="MTHQSHAYHMVKPSPWPLTGALSALLMTSGLAMWFHFHSMTLLM LGLLTNTLTMYQWWRDVTRESTYQGHHTPPVQKGLRYGMILFITSEVFFFAGFFWAFY HSSLAPTPQLGGHWPPTGITPLNPLEVPLLNTSVLLASGVSITWAHHSLMENNRNQMI QALLITILLGLYFTLLQASEYFESPFTISDGIYGSTFFVATGFHGLHVIIGSTFLTIC FIRQLMFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIYWWG" tRNA 9988..10055 /product="tRNA-Gly" CDS 10056..10401 /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:10401,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 3" /protein_id="AAK17643.2" /db_xref="GI:13347061" /translation="MNFALILMINTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPM SPARVPFSMKFFLVAITFLLFDLEIALLLPLPWALQTTNLPLMAMSSLLLIIILALSL AYEWLQKGLDWAE" tRNA 10402..10466 /product="tRNA-Arg" CDS 10467..10763 /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 4L" /protein_id="AAK17644.1" /db_xref="GI:13273027" /translation="MPLIYMNIMLAFTISLLGMLVYRSHLMSSLLCLEGMMLSLFIMA TLMTLNTHSLLANIVPIAMLVFAACEAAVGLALLVSISNTYGLDYVHNLNLLQC" CDS 10757..12134 /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:12134,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 4" /protein_id="AAK17645.2" /db_xref="GI:13347062" /translation="MLKLIVPTIMLLPLTWLSKKHMIWINTTTHSLIISIIPLLFFNQ INNNLFSCSPTFSSDPLTTPLLMLTTWLLPLTIMASQRHLSSEPLSRKKLYLSMLISL QISLIMTFTATELIMFYIFFETTLIPTLAIITRWGNQPERLNAGTYFLFYTLVGSLPL LIALIYTHNTLGSLNILLLTLTAQELSNSWANNLMWLAYTMAFMVKMPLYGLHLWLPK AHVEAPIAGSMVLAAVLLKLGGYGMMRLTLILNPLTKHMAYPFLVLSLWGMIMTSSIC LRQTDLKSLIAYSSISHMALVVTAILIQTPWSFTGAVILMIAHGLTSSLLFCLANSNY ERTHSRIMILSQGLQTLLPLMAFWWLLASLANLALPPTINLLGELSVLVTTFSWSNIT LLLTGLNMLVTALYSLYMFTTTQWGSLTHHINNMKPSFTRENTLMFMHLSPILLLSLN PDIITGFSS" tRNA 12135..12203 /product="tRNA-His" tRNA 12204..12262 /note="codons recognized: UCN" /product="tRNA-Ser" tRNA 12263..12333 /note="codons recognized: UUR" /product="tRNA-Leu" CDS 12334..14145 /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 5" /protein_id="AAK17646.1" /db_xref="GI:13273029" /translation="MTMHTTMTTLTLTSLIPPILTTLVNPNKKNSYPHYVKSIVASTF IISLFPTTMFMCLDQEVIISNWHWATTQTTQLSLSFKLDYFSMMFIPVALFVTWSIME FSLWYMNSDPNINQFFKYLLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLISWWYA RADANTAAIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLNANPSLTPLLGLLL AAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGVFLLIRFHPLAENSPLIQTL TLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAF FKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSK DHIIETANMSYTNAWALSITLIATSLTSAYSTRMILLTLTGQPRFPTLTNINENNPTL LNPIKRLAAGSLFAGFLITNNISPASPFQTTIPLHLKLTALAVTFLGLLTALDLNYLT NKLKMKSPLCTFYFSNMLGFYPSITHRTIPYLGLLTSQNLPLLLLDQTWLEKLLPKTI SQHQISTSIITSTQKGMIKLYFLSFFFPLILTLLLIT" CDS complement(14146..14670) /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 6" /protein_id="AAK17647.1" /db_xref="GI:13273030" /translation="MMYALFLLSVGLVMGFVGFSSKPSPIYGGLVLIVSGVVGCVIIL NFGGGYMGLMVFLIYLGGMMVVFGYTTAMAIEEYPEAWGSGVEVLVSVLVGLAMEVGL VLWVKEYDGVVVVVNFNSVGSWMIYEGEGSGLIREDPIGAGALYDYGRWLVVVTGWTL FVGVYVVIEIARGN" tRNA complement(14671..14739) /product="tRNA-Glu" CDS 14744..15878 /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:15878,aa:TERM) /transl_table=2 /product="cytochrome b" /protein_id="AAK17648.2" /db_xref="GI:13347063" /translation="MTPMRKINPLMKLINHSFIDLPTPSNISAWWNFGSLLGACLILQ ITTGLFLAMHYSPDASTAFSSIAHITRDVNYGWIIRYLHANGASMFFICLFLHIGRGL YYGSFLYSETWNIGIILLLATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDL VQWIWGGYSVDSPTLTRFFTFHFILPFIIAALAALHLLFLHETGSNNPLGITSHSDKI TFHPYYTIKDALGLLLFLLSLMTLTLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLF AYTILRSVPNKLGGVLALLLSILILAMIPILHMSKQQSMMFRPLSQSLYWLLAADLLI LTWIGGQPVSYPFTIIGQVASVLYFTTILILMPTISLIENKMLK" tRNA 15885..15950 /product="tRNA-Thr" tRNA complement(15952..16020) /product="tRNA-Pro" BASE COUNT 5107 a 5183 c 2185 g 4091 t ORIGIN 1 gatcacaggt ctatcaccct attaaccact cacgggagct ctccatgcat ttggtatttt 61 cgtctggggg gtgtgcacgc gatagcattg cgggccgctg gagccggagc accctatgtc 121 gcagtatctg tctttgattc ctgcctcatc ctattattta tcgcacctac gttcaatatt 181 ataggagacc atacctacta aagtgtgtta attaattaat gcttgtagga cataacaata 241 acaattaaat gtctgcacag ccgctttcca cacagacatc ataacaaaaa atttccgcca 301 aaccccccct ccccccactt ctggccacag cacttaaaca catctctgcc aaaccccaaa 361 aacaaagaac cctaacacca gcctaaccag atttcaaatt ttatcttttg gcggtatgca 421 cttttaacag tcacccccca actaacacat tattttcccc tcccactccc atactactaa 481 tctcatcaat acaacccccg cccatcctac ccagcacaca caccgctgct aaccccatac 541 cccgaaccaa ccaaacccca aagacacccc ccacagttta tgtagcttac ctcctcaaag 601 caatacactg aaaatgttta gacgggctca catcacccca taaacaaata ggtttggtcc 661 tagcctttct attagctctt agtaagatta cacatgcaag catccccgtt ccagtgagtt 721 caccctctaa atcaccacga tcaaaaggga caagcatcaa gcacgcaaca atgcagctca 781 aaacgcttag cctagccaca cccccacggg aaacagcagt gataaacctt tagcaataaa 841 cgaaagttta actaagctat actaacccca gggttggtca atttcgtgcc agccaccgcg 901 gtcacacgat taacccaagt caatagaagc cggcgtaaag agtgttttag atcaccccct 961 ccccaataaa gctaaaactc acctgagttg taaaaaactc cagttgacac aaaataaact 1021 acgaaagtgg ctttaacata tctgaacaca caatagctaa gacccaaact gggattagat 1081 accccactat gcttagccct aaacctcaac agttaaatca acaaaactgc tcgccagaac 1141 actacgagcc acagcttaaa actcaaagga cctggcggtg cttcatatcc ctctagagga 1201 gcctgttctg taatcgataa accccgatca acctcaccac ctcttgctca gcctatatac 1261 cgccatcttc agcaaaccct gatgaaggct acaaagtaag cgcaagtacc cacgtaaaga 1321 cgttaggtca aggtgtagcc catgaggtgg caagaaatgg gctacatttt ctaccccaga 1381 aaactacgat agcccttatg aaacttaagg gtcgaaggtg gatttagcag taaactgaga 1441 gtagagtgct tagttgaaca gggccctgaa gcgcgtacac accgcccgtc accctcctca 1501 agtatacttc aaaggacatt taactaaaac ccctacgcat ttatatagag gagacaagtc 1561 gtaacatggt aagtgtactg gaaagtgcac ttggacgaac cagagtgtag cttaacacaa 1621 agcacccaac ttacacttag gagatttcaa cttaacttga ccgctctgag ctaaacctag 1681 ccccaaaccc actccacctt actaccagac aaccttagcc aaaccattta cccaaataaa 1741 gtataggcga tagaaattga aacctggcgc aatagatata gtaccgcaag ggaaagatga 1801 aaaattataa ccaagcataa tatagcaagg actaacccct ataccttctg cataatgaat 1861 taactagaaa taactttgca aggagagcca aagctaagac ccccgaaacc agacgagcta 1921 cctaagaaca gctaaaagag cacacccgtc tatgtagcaa aatagtggga agatttatag 1981 gtagaggcga caaacctacc gagcctggtg atagctggtt gtccaagata gaatcttagt 2041 tcaactttaa atttgcccac agaaccctct aaatcccctt gtaaatttaa ctgttagtcc 2101 aaagaggaac agctctttgg acactaggaa aaaaccttgt agagagagta aaaaatttaa 2161 cacccatagt aggcctaaaa gcagccacca attaagaaag cgttcaagct caacacccac 2221 tacctaaaaa atcccaaaca tataactgaa ctcctcacac ccaattggac caatctatca 2281 ccctatagaa gaactaatgt tagtataagt aacatgaaaa cattctcctc cgcataagcc 2341 tgcgtcagat taaaacactg aactgacaat taacagccca atatctacaa tcaccaacaa 2401 gtcattatta ccctcactgt caacccaaca caggcatgct cataaggaaa ggttaaaaaa 2461 agtaaaagga actcggcaaa tcttaccccg cctgtttacc aaaaacatca cctctagcat 2521 caccagtatt agaggcaccg cctgcccagt gacacatgtt taacggccgc ggtaccctaa 2581 ccgtgcaaag gtagcataat cacttgttcc ttaaataggg acctgtatga atggctccac 2641 gagggttcag ctgtctctta cttttaacca gtgaaattga cctgcccgtg aagaggcggg 2701 catgacacag caagacgaga agaccctatg gagctttaat ttattaatgc aagcaatacc 2761 taacaaaccc acaggtccta aactaccaaa cctgcattaa aaatttcggt tggggcgacc 2821 tcggagcaga acccaacctc cgagcagtac atgctaagac ctcaccagtc aaagcgaact 2881 accatactca attgatccaa taacttgacc aacggaacaa gttaccctag ggataacagc 2941 gcaatcctat tctagagtcc atatcaacaa tagggtttac gacctcgatg ttggatcagg 3001 acatcccgat ggtgcagccg ctattaaagg ttcgtttgtt caacgattaa agtcctacgt 3061 gatctgagtt cagaccggag taatccaggt cggtttctat ctacttcaaa ttcctccctg 3121 tacgaaagga caagagaaat aaggcctact tcacaaagcg ccttcccccg taaatgatat 3181 catctcaact tagtattata cccacaccca cccaagaaca gggtttgtta agatggcaga 3241 gcccggtaat cgcataaaac ttaaaacttt acagtcagag gttcaattcc tcttcttaac 3301 aacataccca tggccaacct cctactcctc attgtaccca ttctaatcgc aatggcattc 3361 ctaatgctta ccgaacgaaa aattctaggc tatatacaac tacgcaaagg ccccaacgtt 3421 gtaggcccct acgggctact acaacccttc gctgacgcca taaaactctt caccaaagag 3481 cccctaaaac ccgccacatc taccatcact ctctacatca ccgccccgac cttagctctc 3541 accatcgctc ttctactatg aacccccctc cccataccca accccctggt taacctcaac 3601 ctaggcctcc tatttattct agccacctct agcctagccg tttactcaat cctctgatca 3661 ggatgagcat caaactcaaa ctacgccctg atcggcgcac tgcgagcagt agcccaaaca 3721 atctcatatg aagtcaccct agccatcatt ctactatcaa cattactaat aagtggctcc 3781 tttaacctct cctcccttat cacaacacaa gaacacctct gattactcct gccatcatgg 3841 cccttggcca taatatgatt tatctccaca ctagcagaga ccaaccgaac ccccttcgac 3901 cttgccgaag gggagtccga actggtctca ggcttcaaca tcgaatacgc cgcaggcccc 3961 ttcgccctat tcttcatagc cgaatacaca aacattatta taataaacac cctcaccact 4021 acaatcttcc taggaacaac atatgacgca ctctcccctg aactctacac aacatatttt 4081 gtcaccaaga ccctacttct gacctccctg ttcttatgaa ttcgaacagc atacccccga 4141 ttccgctacg accaactcat acacctccta tgaaaaaact tcctaccact caccctagca 4201 ttacttatat gatatgtctc catacccatt acaatctcca gcattccccc tcaaacctaa 4261 gaaatatgtc tgataaaaga gttactttga tagagtaaat aataggagct taaaccccct 4321 tatttctagg actatgagaa tcgaacccat ccctgagaat ccaaaattct ccgtgccacc 4381 tatcacaccc catcctaaag taaggtcagc taaataagct atcgggccca taccccgaaa 4441 atgttggtta aacccttccc gtactaatta atcccctggc ccaacccgtc atctactcta 4501 ccgtctttgc aggcacactc atcacagcgc taagctcgca ctgatttttt acctgagtag 4561 gcctagaaat aaacatgcta gcttttattc cagttctaac caaaaaaata aaccctcgtt 4621 ccacagaagc tgccatcaag tatttcctca cgcaagcaac cgcatccata atccttctaa 4681 tagctatcct cttcaacaat atactctccg gacaatgaac cataaccaat actaccaatc 4741 aatactcatc attaataatc ataatggcta tagcaataaa actaggaata gccccctttc 4801 acttctgagt cccagaggtt acccaaggca cccctctgac atccggcctg cttcttctca 4861 catgacaaaa actagccccc atctcaatca tataccaaat ctctccctca ctaaacgtaa 4921 gccttctcct cactctctca atcttatcca tcatagcagg cagttgaggt ggattaaacc 4981 aaacccagct acgcaaaatc ttagcatact cctcaattac ccacatagga tgaataatag 5041 cagttctacc gtacaaccct aacataacca ttcttaattt aactatttat attatcctaa 5101 ctactaccgc attcctacta ctcaacttaa actccagcac cacgacccta ctactatctc 5161 gcacctgaaa caagctaaca tgactaacac ccttaattcc atccaccctc ctctccctag 5221 gaggcctgcc cccgctaacc ggctttttgc ccaaatgggc cattatcgaa gaattcacaa 5281 aaaacaatag cctcatcatc cccaccatca tagccaccat caccctcctt aacctctact 5341 tctacctacg cctaatctac tccacctcaa tcacactact ccccatatct aacaacgtaa 5401 aaataaaatg acagtttgaa catacaaaac ccaccccatt cctccccaca ctcatcgccc 5461 ttaccacgct actcctacct atctcccctt ttatactaat aatcttatag aaatttaggt 5521 taaatacaga ccaagagcct tcaaagccct cagtaagttg caatacttaa tttctgtaac 5581 agctaaggac tgcaaaaccc cactctgcat caactgaacg caaatcagcc actttaatta 5641 agctaagccc ttactagacc aatgggactt aaacccacaa acacttagtt aacagctaag 5701 caccctaatc aactggcttc aatctacttc tcccgccgcc gggaaaaaag gcgggagaag 5761 ccccggcagg tttgaagctg cttcttcgaa tttgcaattc aatatgaaaa tcacctcgga 5821 gctggtaaaa agaggcctaa cccctgtctt tagatttaca gtccaatgct tcactcagcc 5881 attttacctc acccccactg atgttcgccg accgttgact attctctaca aaccacaaag 5941 acattgggac actataccta ttattcggcg catgagctgg agtcctaggc acagctctaa 6001 gcctccttat tcgagccgag ctgggccagc caggcaacct tctaggtaac gaccacatct 6061 acaacgtcat cgtcacagcc catgcatttg taataatctt cttcatagta atacccatca 6121 taatcggagg ctttggcaac tgactagttc ccctaataat cggtgccccc gatatggcgt 6181 ttccccgcat aaacaacata agcttctgac tcttacctcc ctctctccta ctcctgctcg 6241 catctgctat agtggaggcc ggagcaggaa caggttgaac agtctaccct cccttagcag 6301 ggaactactc ccaccctgga gcctccgtag acctaaccat cttctcctta cacctagcag 6361 gtgtctcctc tatcttaggg gccatcaatt tcatcacaac aattatcaat ataaaacccc 6421 ctgccataac ccaataccaa acgcccctct tcgtctgatc cgtcctaatc acagcagtcc 6481 tacttctcct atctctccca gtcctagctg ctggcatcac tatactacta acagaccgca 6541 acctcaacac caccttcttc gaccccgccg gaggaggaga ccccattcta taccaacacc 6601 tattctgatt tttcggtcac cctgaagttt atattcttat cctaccaggc ttcggaataa 6661 tctcccatat tgtaacttac tactccggaa aaaaagaacc atttggatac ataggtatgg 6721 tctgagctat gatatcaatt ggcttcctgg ggtttatcgt gtgagcacac catatattta 6781 cagtaggaat agacgtagac acacgagcat atttcacctc cgctaccata atcatcgcta 6841 tccccaccgg cgtcaaagta tttagctgac tcgccacact ccacggaagc aatatgaaat 6901 gatctgctgc agtgctctga gccctaggat tcatctttct tttcaccgta ggtggcctga 6961 ctggcattgt attagcaaac tcatcactag acatcgtact acacgacacg tactacgttg 7021 tagctcactt ccactatgtc ctatcaatag gggctgtatt tgccatcata ggaggcttca 7081 ttcactgatt tcccctattc tcaggctaca ccctagacca aacctacgcc aaaatccatt 7141 tcgctatcat attcatcggc gtaaatctaa ctttcttccc acaacacttt ctcggcctgt 7201 ccggaatgcc ccgacgttac tcggactacc ccgatgcata caccacatga aatatcctat 7261 catctgtagg ctcattcatt tctctaacag cagtaatatt aataattttc atgatttgag 7321 aagccttcgc ttcgaagcga aaagtcctaa tagtagaaga accctccata aacctggagt 7381 gactacatgg atgcccccca ccctaccaca cattcgaaga acccgtatac ataaaatcta 7441 gacaaaaaag gaaggaatcg aaccccccaa agctggtttc aagccaaccc catggcctcc 7501 atgacttttt caaaaagata ttagaaaaac catttcataa ctttgtcaaa gttaaattat 7561 aggctaagtc ctatatatct taatggcaca tgcagcgcaa gtaggtctac aagacgctac 7621 ttcccctatc atagaagagc ttatcacctt tcatgaccac gccctcataa tcattttcct 7681 tatctgcttt ctagtcctgt atgccctttt cctaacactc acaacaaaac taactaatac 7741 taacatctca gacgctcagg aaatagaaac cgtctgaact atcctgcccg ccatcatcct 7801 agtcctcatc gccctcccat ccctacgcat cctttacata acagacgagg tcaacgatcc 7861 ctcccttacc atcaaatcaa ttggccacca atggtactga acctacgagt acaccgacta 7921 cggcggacta atcttcaact cctacatact tcccccatta ttcctagaac caggcgacct 7981 gcgactcctt gacgttgaca atcgagtagt actcccgatt gaaaccccca ttcgtataat 8041 aattacatca caagacgtct tgcactcatg agctgtcccc acactaggct taaaaacaga 8101 tgcaattccc ggacgtctaa accaaaccac tttcaccgct acacgaccgg gggtatacta 8161 cggtcaatgc tctgaaatct gtggagcaaa ccacagtttc atgcccatcg tcctagaatt 8221 aattccccta aaaatctttg aaatagggcc cgtatttacc ctatagcacc ccctctaccc 8281 cctctagagc ccactgtaaa gctaacttag cattaacctt ttaagttaaa gattaagaga 8341 accaacacct ctttacagtg aaatgcccca actaaatact accgtatggc ccaccataat 8401 tacccccata ctccttacac tattcctcat cacccaacta aaaatattaa acacaaacta 8461 ccacttacct ccctcaccaa agcccataaa aataaaaaat tataacaaac cctgagaacc 8521 aaaatgaacg aaaatctgtt cgcttcattc attgccccca caatcctagg cctacccgcc 8581 gcagtactga tcattctatt tccccctcta ttgatcccca cctccaaata tctcatcaac 8641 aaccgactaa ttaccaccca acaatgacta atcaaactaa cctcaaaaca aatgatagcc 8701 atacacaaca ctaaaggacg aacctgatct cttatactag tatccttaat catttttatt 8761 gccacaacta acctcctcgg actcctgcct cactcattta caccaaccac ccaactatct 8821 ataaacctag ccatggccat ccccttatga gcgggcgcag tgattatagg ctttcgctct 8881 aagattaaaa atgccctagc ccacttctta ccacaaggca cacctacacc ccttatcccc 8941 atactagtta ttatcgaaac catcagccta ctcattcaac caatagccct ggccgtacgc 9001 ctaaccgcta acattactgc aggccaccta ctcatgcacc taattggaag cgccacccta 9061 gcaatatcga ccattaacct tccctctaca cttatcatct tcacaattct aattctactg 9121 actatcctag aaatcgctgt cgccttaatc caagcctacg ttttcacact tctagtaagc 9181 ctctacctgc acgacaacac ataatgaccc accaatcaca tgcctatcat atagtaaaac 9241 ccagcccatg acccctaaca ggggcccttt cagccctcct aatgacctcc ggcctagcca 9301 tgtgatttca cttccactcc ataacgctcc tcatactagg cctactaacc aacacactaa 9361 ccatatacca atgatggcgc gatgtaacac gagaaagcac ataccaaggc caccacacac 9421 cacctgtcca aaaaggcctt cgatacggga taatcctatt tattacctca gaagtttttt 9481 tcttcgcagg atttttctga gccttttacc actccagcct agcccctacc ccccaactag 9541 gagggcactg gcccccaaca ggcatcaccc cgctaaatcc cctagaagtc ccactcctaa 9601 acacatccgt attactcgca tcaggagtat caatcacctg agcccaccat agtctaatag 9661 aaaacaaccg aaaccaaata attcaagcac tgcttattac aattttactg ggtctctatt 9721 ttaccctcct acaagcctca gagtacttcg agtctccctt caccatttcc gacggcatct 9781 acggctcaac attttttgta gccacaggct tccacggact tcacgtcatt attggctcaa 9841 ctttcctcac tatctgcttc atccgccaac taatatttca ctttacatcc aaacatcact 9901 ttggcttcga agccgccgcc tgatactggc attttgtaga tgtggtttga ctatttctgt 9961 atgtctccat ctattgatga gggtcttact cttttagtat aaatagtacc gttaacttcc 10021 aattaactag ttttgacaac attcaaaaaa gagtaataaa cttcgcctta attttaataa 10081 tcaacaccct cctagcctta ctactaataa ttattacatt ttgactacca caactcaacg 10141 gctacataga aaaatccacc ccttacgagt gcggcttcga ccctatatcc cccgcccgcg 10201 tccctttctc cataaaattc ttcttagtag ctattacctt cttattattt gatctagaaa 10261 ttgccctcct tttaccccta ccatgagccc tacaaacaac taacctgcca ctaatagcta 10321 tgtcatccct cttattaatc atcatcctag ccctaagtct ggcctatgag tgactacaaa 10381 aaggattaga ctgagccgaa ttggtatata gtttaaacaa aacgaatgat ttcgactcat 10441 taaattatga taatcatatt taccaaatgc ccctcattta cataaatatt atactagcat 10501 ttaccatctc acttctagga atactagtat atcgctcaca cctcatatcc tccctactat 10561 gcctagaagg aataatacta tcactgttca ttatagctac tctcataacc ctcaacaccc 10621 actccctctt agccaatatt gtgcctattg ccatactagt ctttgccgcc tgcgaagcag 10681 cggtaggcct agccctacta gtctcaatct ccaacacata tggcctagac tacgtacata 10741 acctaaacct actccaatgc taaaactaat cgtcccaaca attatattac taccactgac 10801 atgactctcc aaaaaacaca taatttgaat caacacaacc acccacagcc taattattag 10861 catcatcccc ctactatttt ttaaccaaat caacaacaac ctatttagct gttccccaac 10921 cttttcctcc gaccccctaa caacccccct cctaatacta actacctgac tcctacccct 10981 cacaatcatg gcaagccaac gccacttatc cagtgaacca ctatcacgaa aaaaactcta 11041 cctctctata ctaatctccc tacaaatctc cttaattata acattcacag ccacagaact 11101 aatcatattt tatatcttct tcgaaaccac acttatcccc accttggcta tcatcacccg 11161 atgaggcaac cagccagaac gcctgaacgc aggcacatac ttcctattct acaccctagt 11221 aggctccctt cccctactca tcgcactaat ttacactcac aacaccctag gctcactaaa 11281 cattctacta ctcactctca ctgcccaaga actatcaaac tcctgagcca acaacttaat 11341 atgactagct tacacaatag cttttatagt aaagatacct ctttacggac tccacttatg 11401 actccctaaa gcccatgtcg aagcccccat cgctgggtca atagtacttg ccgcagtact 11461 cttaaaacta ggcggctatg gtataatacg cctcacactc attctcaacc ccctgacaaa 11521 acacatagcc taccccttcc ttgtactatc cctatgaggc ataattataa caagctccat 11581 ctgcctacga caaacagacc taaaatcgct cattgcatac tcttcaatca gccacatagc 11641 cctcgtagta acagccattc tcatccaaac cccctgaagc ttcaccggcg cagtcattct 11701 cataatcgcc cacggactta catcctcatt actattctgc ctagcaaact caaactacga 11761 acgcactcac agtcgcatca taatcctctc tcaaggactt caaactctac tcccactaat 11821 agctttttga tgacttctag caagcctcgc taacctcgcc ttacccccca ctattaacct 11881 actgggagaa ctctccgtgc tagtaaccac gttctcctga tcaaatatca ctctcctact 11941 tacaggactc aacatactag tcacagccct atactccctc tacatattta ccacaacaca 12001 atggggctca ctcacccacc acattaacaa cataaaaccc tcattcacac gagaaaacac 12061 cctcatgttc atacacctat cccccattct cctcctatcc ctcaaccccg acatcattac 12121 cgggttttcc tcttgtaaat atagtttaac caaaacatca gattgtgaat ctgacaacag 12181 aggcttacga ccccttattt accgagaaag ctcacaagaa ctgctaactc atgcccccat 12241 gtctaacaac atggctttct caacttttaa aggataacag ctatccattg gtcttaggcc 12301 ccaaaaattt tggtgcaact ccaaataaaa gtaataacca tgcacactac tataaccacc 12361 ctaaccctga cttccctaat tccccccatc cttaccaccc tcgttaaccc taacaaaaaa 12421 aactcatacc cccattatgt aaaatccatt gtcgcatcca cctttattat cagtctcttc 12481 cccacaacaa tattcatgtg cctagaccaa gaagttatta tctcgaactg acactgagcc 12541 acaacccaaa caacccagct ctccctaagc ttcaaactag actacttctc cataatattc 12601 atccctgtag cattgttcgt tacatggtcc atcatagaat tctcactgtg atatataaac 12661 tcagacccaa acattaatca gttcttcaaa tatctactca ttttcctaat taccatacta 12721 atcttagtta ccgctaacaa cctattccaa ctgttcatcg gctgggaggg cgtaggaatt 12781 atatccttct tgctcatcag ttgatggtac gcccgagcag atgccaacac agcagccatt 12841 caagcaatcc tatacaaccg tatcggcgat atcggtttca tcctcgcctt agcatgattt 12901 atcctacact ccaactcatg agacccacaa caaatagccc ttctaaacgc taatccaagc 12961 ctcaccccac tactaggcct cctcctagca gcagcaggca aatcagccca attaggtctc 13021 cacccctgac tcccctcagc catagaaggc cccaccccag tctcagccct actccactca 13081 agcactatag ttgtagcagg agtcttctta ctcatccgct tccaccccct agcagaaaat 13141 agcccactaa tccaaactct aacactatgc ttaggcgcta tcaccactct gttcgcagca 13201 gtctgcgccc ttacacaaaa tgacatcaaa aaaatcgtag ccttctccac ttcaagtcaa 13261 ctaggactca taatagttac aatcggcatc aaccaaccac acctagcatt cctgcacatc 13321 tgtacccacg ccttcttcaa agccatacta tttatgtgct ccgggtccat catccacaac 13381 cttaacaatg aacaagatat tcgaaaaata ggaggactac tcaaaaccat acctctcact 13441 tcaacctccc tcaccattgg cagcctagca ttagcaggaa tgcctttcct cacaggtttc 13501 tattccaaag accacatcat cgaaaccgca aacatatcat acacaaacgc ctgagcccta 13561 tctattactc tcatcgctac ctccctgaca agcgcctata gcactcgaat aattcttctc 13621 accctaacag gtcaacctcg cttccctacc cttactaaca ttaacgaaaa taaccccacc 13681 ctactaaacc ccattaaacg cctggcagcc ggaagcctat tcgcaggatt tctcattact 13741 aacaacattt cccccgcatc ccccttccaa acaacaatcc ccctccacct aaaactcaca 13801 gccctcgctg tcactttcct aggacttcta acagccctag acctcaacta cctaaccaac 13861 aaacttaaaa taaaatcccc actatgcaca ttttatttct ccaacatact cggattctac 13921 cctagcatca cacaccgcac aatcccctat ctaggccttc ttacgagcca aaacctgccc 13981 ctactcctcc tagaccaaac ctgactagaa aagctattac ctaaaacaat ttcacagcac 14041 caaatctcca cctccatcat cacctcaacc caaaaaggca taatcaaact ttacttcctc 14101 tctttcttct tcccactcat cctaacccta ctcctaatca catagcctat tcccccgagc 14161 aatctcaatt acaacatata caccaacaaa caatgttcaa ccagtaacta ctactaatca 14221 acgcccataa tcatacaaag cccccgcacc aataggatcc tcccgaatca accctgaccc 14281 ctctccttca taaattattc agcttcctac actattaaag tttaccacaa ccaccacccc 14341 atcatactct ttcacccaca gcaccaatcc tacctccatc gctaacccca ctaaaacact 14401 caccaagacc tcaacccctg acccccatgc ctcaggatac tcctcaatag ccatcgctgt 14461 agtatatcca aagacaacca tcattccccc taaataaatt aaaaaaacta ttaaacccat 14521 ataacctccc ccaaaattca gaataataac acacccaacc acaccgctaa caatcaatac 14581 taaaccccca taaataggag aaggcttaga agaaaacccc acaaacccca ttactaaacc 14641 cacactcaac agaaacaaag catacatcat tattctcgca cggactacaa ccacgaccaa 14701 tgatatgaaa aaccatcgtt gtatttcaac tacaagaaca ccaatgaccc caatacgcaa 14761 aattaacccc ctaataaaat taattaacca ctcattcatc gacctcccca ccccatccaa 14821 catctccgca tgatgaaact tcggctcact ccttggcgcc tgcctgatcc tccaaatcac 14881 cacaggacta ttcctagcca tgcactattc accagacgcc tcaaccgcct tttcatcaat 14941 cgcccacatc actcgagacg taaattatgg ctgaatcatc cgctaccttc acgccaatgg 15001 cgcctcaata ttctttatct gcctcttcct acacatcggg cgaggcctat attacggatc 15061 atttctctac tcagaaacct gaaacatcgg cattatcctc ctgcttgcaa ctatagcaac 15121 agccttcata ggctatgtcc tcccgtgagg ccaaatatca ttctgagggg ccacagtaat 15181 tacaaactta ctatccgcca tcccatacat tgggacagac ctagttcaat gaatctgagg 15241 aggctactca gtagacagtc ccaccctcac acgattcttt acctttcact tcatcttgcc 15301 cttcattatt gcagccctag cagcactcca cctcctattc ttgcacgaaa cgggatcaaa 15361 caacccccta ggaatcacct cccattccga taaaatcacc ttccaccctt actacacaat 15421 caaagacgcc ctcggcttac ttctcttcct tctctcctta atgacattaa cactattctc 15481 accagacctc ctaggcgacc cagacaatta taccctagcc aaccccttaa acacccctcc 15541 ccacatcaag cccgaatgat atttcctatt cgcctacaca attctccgat ccgtccctaa 15601 caaactagga ggcgtccttg ccctattact atccatcctc atcctagcaa taatccccat 15661 cctccatata tccaaacaac aaagcataat atttcgccca ctaagccaat cactttattg 15721 actcctagcc gcagacctcc tcattctaac ctgaatcgga ggacaaccag taagctaccc 15781 ttttaccatc attggacaag tagcatccgt actatacttc acaacaatcc taatcctaat 15841 accaactatc tccctaattg aaaacaaaat actcaaatgg gcctgtcctt gtagtataaa 15901 ctaatacacc agtcttgtaa accggagatg aaaacctttt tccaaggaca aatcagagaa 15961 aaagtcttta actccaccat tagcacccaa agctaagatt ctaatttaaa ctattctctg 16021 ttctttcatg gggaagcaga tttgggtacc acccaagtat tgactcaccc atcaacaacc 16081 gctatgtatt tcgtacatta ctgccagcca ccatgaatat tgtacagtac cataaatact 16141 tgaccacctg tagtacataa aaacccaatc cacatcaaaa ccctcccccc atgcttacaa 16201 gcaagtacag caatcaacct tcaactatca cacatcaact gcaactccaa agccacccct 16261 cacccactag aatatcaaca aacctacccg tccttaacag tacatagcac ataaagccat 16321 ttaccgtaca tagcacatta cagtcaaatc ccttcttgtc cccatggatg acccccctca 16381 gataggggtc ccttgaccac catcctccgt gaaatcaata tcccgcacaa gagtgctact 16441 ctcctcgctc cgggcccata acacttgggg gtagctaaag tgaactgtat ccgacatctg 16501 gttcctactt cagggccata aagcctaaat agcccacacg ttccccttaa ataagacatc 16561 acgatg //