BLASTP 2.0.10 [Aug-26-1999] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402.Query= a q (824 letters) Database: Non-redundant GenBank CDS translations+PDB+SwissProt+SPupdate+PIR 444,417 sequences; 136,724,657 total letters
If you have any problems or questions with the results of this search
please refer to the BLAST FAQs
Score E Sequences producing significant alignments: (bits) Value gb|AAD35261.1|AE001702_1 (AE001702) leucyl-tRNA synthetase ... 1620 0.0 sp|P73274|SYL_SYNY3 LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA L... 828 0.0 sp|P36430|SYL_BACSU LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA L... 762 0.0 gb|AAF11720.1|AE002050_6 (AE002050) leucyl-tRNA synthetase ... 762 0.0 sp|P43827|SYL_HAEIN LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA L... 748 0.0 pir||A41882 leucine--tRNA ligase (EC 6.1.1.4) - Bacillus su... 738 0.0 sp|P07813|SYL_ECOLI LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA L... 732 0.0 gi|1778560 (U82598) leucine tRNA synthetase [Escherichia coli] 732 0.0 pir||SYECL leucine--tRNA ligase (EC 6.1.1.4) - Escherichia ... 728 0.0 gi|4156066 (AE001567) LEUCYL-TRNA SYNTHETASE [Helicobacter ... 695 0.0 gi|2688147 (AE001135) leucyl-tRNA synthetase (leuS) [Borrel... 695 0.0 sp|O83595|SYL_TREPA LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA L... 693 0.0 sp|P56457|SYL_HELPY LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA L... 693 0.0 sp|Q9ZDB1|SYL_RICPR LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA L... 692 0.0 gb|AAD36946.1|AF069441_6 (AF069441) putative leucyl tRNA sy... 676 0.0 sp|O66680|SYL_AQUAE LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA L... 652 0.0 sp|Q09828|SYLM_SCHPO PUTATIVE LEUCYL-TRNA SYNTHETASE, MITOC... 606 e-172 gb|AAC67801.1| (AE001294) Leucyl tRNA Synthetase [Chlamydia... 588 e-167 gb|AAD18306| (AE001602) Leucyl tRNA Synthetase [Chlamydia p... 571 e-161 sp|P13503|SYLM_SACDO LEUCYL-TRNA SYNTHETASE, MITOCHONDRIAL ... 564 e-159 sp|P15181|SYLM_NEUCR LEUCYL-TRNA SYNTHETASE, MITOCHONDRIAL ... 554 e-156 sp|Q50192|SYL_MYCLE LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA L... 552 e-156 sp|P71698|SYL_MYCTU LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA L... 552 e-156 ref|NP_013486.1|NAM2| mitochondrial leucyl tRNA synthetase;... 549 e-155 sp|Q15031|SYLM_HUMAN PROBABLE LEUCYL-TRNA SYNTHETASE, MITOC... 534 e-150 sp|P75398|SYL_MYCPN LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA L... 501 e-140 sp|P47508|SYL_MYCGE LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA L... 480 e-134 emb|CAA94727| (Z70722) leucyl-tRNA synthase [Mycobacterium ... 434 e-120 emb|CAA98144.2| (Z73912) predicted using Genefinder; Simila... 337 2e-91 gi|2984068 (AE000755) leucyl-tRNA synthetase beta subunit [... 254 2e-66 gb|AAD36880.1|AE001819_3 (AE001819) valyl-tRNA synthetase [... 249 9e-65 sp|O26861|SYV_METTH VALYL-TRNA SYNTHETASE (VALINE--TRNA LIG... 244 2e-63 sp|Q58413|SYV_METJA VALYL-TRNA SYNTHETASE (VALINE--TRNA LIG... 230 4e-59 sp|O30250|SYL_ARCFU LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA L... 205 2e-51 sp|O27428|SYI_METTH ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--... 201 2e-50 sp|P26499|SYI_METTM ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--... 198 1e-49 pir||SYEXI isoleucine--tRNA ligase (EC 6.1.1.5) - Methanoba... 198 1e-49 sp|Q05873|SYV_BACSU VALYL-TRNA SYNTHETASE (VALINE--TRNA LIG... 185 1e-45 sp|P96142|SYV_THETH VALYL-TRNA SYNTHETASE (VALINE--TRNA LIG... 183 4e-45 dbj|BAA24690| (AB010832) ORF3; putative leucyl-tRNA synthas... 178 2e-43 sp|O27552|SYL_METTH LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA L... 171 2e-41 sp|P56000|SYV_HELPY VALYL-TRNA SYNTHETASE (VALINE--TRNA LIG... 170 3e-41 gi|4155674 (AE001535) VALYL-TRNA SYNTHETASE [Helicobacter p... 166 7e-40 sp|Q55522|SYV_SYNY3 VALYL-TRNA SYNTHETASE (VALINE--TRNA LIG... 165 1e-39 pir||A64379 isoleucine--tRNA ligase (EC 6.1.1.5) - Methanoc... 162 1e-38 sp|Q58050|SYL_METJA LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA L... 162 1e-38 dbj|BAA29387.1| (AP000001) 896aa long hypothetical valyl-tR... 161 2e-38 emb|CAB50557.1| (AJ248288) valyl-tRNA synthetase (valS) [Py... 157 3e-37 gb|AAD50458.1|AF169967_1 (AF169967) LeuS [Flavobacterium jo... 153 4e-36 pir||SYBSVS valine--tRNA ligase (EC 6.1.1.9) - Bacillus ste... 151 3e-35 gb|AAF09735.1|AE001877_2 (AE001877) valyl-tRNA synthetase [... 150 4e-35 sp|P43834|SYV_HAEIN VALYL-TRNA SYNTHETASE (VALINE--TRNA LIG... 148 2e-34 sp|P11931|SYV_BACST VALYL-TRNA SYNTHETASE (VALINE--TRNA LIG... 148 2e-34 gi|2688775 (AE001181) isoleucyl-tRNA synthetase (ileS) [Bor... 146 8e-34 sp|P41972|SYI_STAAU ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--... 144 2e-33 emb|CAA21241.1| (AL031852) valyl-trna synthetase, mitochond... 143 6e-33 pdb|1QU2|A Chain A, Insights Into Editing From An Ile-Trna ... 142 1e-32 ref|NP_011608.1|VAS1| mitochondrial and cytoplasmic valyl-t... 141 2e-32 gi|173164 (J02719) valyl-tRNA synthetase [Saccharomyces cer... 141 2e-32 sp|P36420|SYV_LACCA VALYL-TRNA SYNTHETASE (VALINE--TRNA LIG... 136 6e-31 sp|O58792|SYI_PYRHO ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--... 133 5e-30 emb|CAB49833.1| (AJ248285) isoleucyl-tRNA synthetase (ileS)... 132 1e-29 sp|O66651|SYI_AQUAE ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--... 131 2e-29 sp|Q58357|SYI_METJA ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--... 131 3e-29 sp|O28059|SYV_ARCFU VALYL-TRNA SYNTHETASE (VALINE--TRNA LIG... 129 7e-29 sp|P56690|SYI_THETH ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--... 127 4e-28 sp|O84304|SYV_CHLTR VALYL-TRNA SYNTHETASE (VALINE--TRNA LIG... 124 2e-27 emb|CAA83690| (Z33008) Leu-tRNA synthetase [Mycoplasma capr... 123 4e-27 emb|CAB57581.1| (Y18930) isoleucyl-tRNA synthetase [Sulfolo... 123 5e-27 sp|O51680|SYV_BORBU VALYL-TRNA SYNTHETASE (VALINE--TRNA LIG... 123 7e-27 emb|CAB49785.1| (AJ248285) leucyl-tRNA synthetase (leuS) [P... 119 8e-26 sp|P47576|SYV_MYCGE VALYL-TRNA SYNTHETASE (VALINE--TRNA LIG... 118 1e-25 sp|O29622|SYI_ARCFU ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--... 116 7e-25 sp|P46213|SYI_THEMA ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--... 116 9e-25 sp|P23920|SYM_BACST METHIONYL-TRNA SYNTHETASE (METHIONINE--... 115 2e-24 dbj|BAA30062| (AP000004) 967aa long hypothetical leucyl-tRN... 113 8e-24 sp|O67411|SYV_AQUAE VALYL-TRNA SYNTHETASE (VALINE--TRNA LIG... 112 1e-23 sp|Q9ZCN6|SYV_RICPR VALYL-TRNA SYNTHETASE (VALINE--TRNA LIG... 107 3e-22 sp|P07118|SYV_ECOLI VALYL-TRNA SYNTHETASE (VALINE--TRNA LIG... 105 1e-21 pir||SYECVT valine--tRNA ligase (EC 6.1.1.9) - Escherichia ... 105 1e-21 gi|147906 (J03497) valyl tRNA synthetase [Escherichia coli] 105 1e-21 gi|537100 (U14003) valyl-tRNA synthetase [Escherichia coli] 105 1e-21 emb|CAA83702| (Z33021) Leu-tRNA synthetase [Mycoplasma capr... 104 3e-21 emb|CAB57710.1| (Y18930) isoleucyl-trna synthetase [Sulfolo... 103 7e-21 gb|AAD30388.1|AF096862_2 (AF096862) isoleucyl-tRNA synthase... 101 3e-20 sp|P41368|SYIP_STAAU ISOLEUCYL-TRNA SYNTHETASE, MUPIROCIN R... 99 1e-19 sp|Q58659|SYM_METJA METHIONYL-TRNA SYNTHETASE (METHIONINE--... 97 5e-19 emb|CAB51985.1| (AL109663) putative isoleucyl-tRNA syntheta... 96 1e-18 sp|O83998|SYV_TREPA VALYL-TRNA SYNTHETASE (VALINE--TRNA LIG... 94 3e-18 dbj|BAA80808.1| (AP000062) 889aa long hypothetical valyl-tR... 94 4e-18 gb|AAC67609.1| (AE001277) Isoleucyl-tRNA Synthetase [Chlamy... 93 8e-18 sp|P93736|SYV_ARATH VALYL-TRNA SYNTHETASE (VALINE--TRNA LIG... 93 1e-17 dbj|BAA79329.1| (AP000059) 1064aa long hypothetical isoleuc... 92 2e-17 gi|4009476 (AF068901) isoleucine-tRNA synthetase [Streptoco... 90 7e-17 sp|Q45477|SYI_BACSU ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--... 90 7e-17 emb|CAA83800| (Z33244) Leu-tRNA synthetase [Mycoplasma capr... 90 9e-17 gi|409847 (U01780) Significant homology to leucine tRNA syn... 89 2e-16 sp|O28819|SYM_ARCFU METHIONYL-TRNA SYNTHETASE (METHIONINE--... 88 3e-16 gb|AAD18262| (AE001597) Isoleucyl-tRNA Synthetase [Chlamydi... 87 6e-16 sp|O53175|SYV_MYCTU VALYL-TRNA SYNTHETASE (VALINE--TRNA LIG... 85 2e-15gb|AAD35261.1|AE001702_1 (AE001702) leucyl-tRNA synthetase [Thermotoga maritima] Length = 824 Score = 1620 bits (4150), Expect = 0.0 Identities = 782/824 (94%), Positives = 782/824 (94%) Query: 1 MKEYRPXXXXXXXXXXXXXXXXFYTPQRSEKPKYYALVMFPYPSGTLHVGHVKNYVIGDI 60 MKEYRP FYTPQRSEKPKYYALVMFPYPSGTLHVGHVKNYVIGDI Sbjct: 1 MKEYRPQEIEKKWQEVWEEKKVFYTPQRSEKPKYYALVMFPYPSGTLHVGHVKNYVIGDI 60 Query: 61 VARYKRMRGYNVLHPFGYDAFGLPAENAAIEKGIHPEEWTRKNIATIRQQVKKLGISYDW 120 VARYKRMRGYNVLHPFGYDAFGLPAENAAIEKGIHPEEWTRKNIATIRQQVKKLGISYDW Sbjct: 61 VARYKRMRGYNVLHPFGYDAFGLPAENAAIEKGIHPEEWTRKNIATIRQQVKKLGISYDW 120 Query: 121 SREIATCDEEYYKWTQWIFLQLYKNGLAYKKKAAVNWCPKCKTVLANEQVKDGKCERCGT 180 SREIATCDEEYYKWTQWIFLQLYKNGLAYKKKAAVNWCPKCKTVLANEQVKDGKCERCGT Sbjct: 121 SREIATCDEEYYKWTQWIFLQLYKNGLAYKKKAAVNWCPKCKTVLANEQVKDGKCERCGT 180 Query: 181 SVTIRHLEQWFFKITDYAERLLNDLDKLTGWPEHVKTMQRNWIGKSTGAEIDFPVEGSDT 240 SVTIRHLEQWFFKITDYAERLLNDLDKLTGWPEHVKTMQRNWIGKSTGAEIDFPVEGSDT Sbjct: 181 SVTIRHLEQWFFKITDYAERLLNDLDKLTGWPEHVKTMQRNWIGKSTGAEIDFPVEGSDT 240 Query: 241 KIRVFTTRPDTLWGVTFMXXXXXXXXXXXXXXXXXXXXXXXXXXRVKQQDRFRRTSVEAE 300 KIRVFTTRPDTLWGVTFM RVKQQDRFRRTSVEAE Sbjct: 241 KIRVFTTRPDTLWGVTFMALAPESPLVEELVPEEKKEELQEFLERVKQQDRFRRTSVEAE 300 Query: 301 KEGFFLGRYAINPVTGERIPIYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPIKVV 360 KEGFFLGRYAINPVTGERIPIYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPIKVV Sbjct: 301 KEGFFLGRYAINPVTGERIPIYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPIKVV 360 Query: 361 IKPADKDLDPEKMEEAYEGEGIMVNSGPFDGTPSSEGIEKVINWLEEKGIGKRSVQYKLR 420 IKPADKDLDPEKMEEAYEGEGIMVNSGPFDGTPSSEGIEKVINWLEEKGIGKRSVQYKLR Sbjct: 361 IKPADKDLDPEKMEEAYEGEGIMVNSGPFDGTPSSEGIEKVINWLEEKGIGKRSVQYKLR 420 Query: 421 DWLISRQRYWGAPIPIIYCEKCGVVPVPEEDLPVRLPKDVEFLPTGQSPLSFHEGFKKTK 480 DWLISRQRYWGAPIPIIYCEKCGVVPVPEEDLPVRLPKDVEFLPTGQSPLSFHEGFKKTK Sbjct: 421 DWLISRQRYWGAPIPIIYCEKCGVVPVPEEDLPVRLPKDVEFLPTGQSPLSFHEGFKKTK 480 Query: 481 CPVCGGEAQRETDTMDTFVDSSWYFLRYVNPHLEDKPFEPDDVNYWLPVDQYIGGVEHAV 540 CPVCGGEAQRETDTMDTFVDSSWYFLRYVNPHLEDKPFEPDDVNYWLPVDQYIGGVEHAV Sbjct: 481 CPVCGGEAQRETDTMDTFVDSSWYFLRYVNPHLEDKPFEPDDVNYWLPVDQYIGGVEHAV 540 Query: 541 LHLLYSRFVTKVLHDLGYLNFDEPFTNLFTQGMIYKDGAKMSKSKGNVVSPDEMIEKYGA 600 LHLLYSRFVTKVLHDLGYLNFDEPFTNLFTQGMIYKDGAKMSKSKGNVVSPDEMIEKYGA Sbjct: 541 LHLLYSRFVTKVLHDLGYLNFDEPFTNLFTQGMIYKDGAKMSKSKGNVVSPDEMIEKYGA 600 Query: 601 DTLRMYILFMAPPEKDAEWSDAGIEGVHRFVKRLWNTFYTVLPFVKEENTENLVLKNSTE 660 DTLRMYILFMAPPEKDAEWSDAGIEGVHRFVKRLWNTFYTVLPFVKEENTENLVLKNSTE Sbjct: 601 DTLRMYILFMAPPEKDAEWSDAGIEGVHRFVKRLWNTFYTVLPFVKEENTENLVLKNSTE 660 Query: 661 KELRRKLHSIIKKITEDIEGGFKFNTAISGLMELVNHLSQYLNSVPQEEWNRKLLREIVE 720 KELRRKLHSIIKKITEDIEGGFKFNTAISGLMELVNHLSQYLNSVPQEEWNRKLLREIVE Sbjct: 661 KELRRKLHSIIKKITEDIEGGFKFNTAISGLMELVNHLSQYLNSVPQEEWNRKLLREIVE 720 Query: 721 KLTLALSPFAPHLAEEFWHDLGNDSLVVQQSWPSYDPKALEVEEVEIAIQINGKVRDKVV 780 KLTLALSPFAPHLAEEFWHDLGNDSLVVQQSWPSYDPKALEVEEVEIAIQINGKVRDKVV Sbjct: 721 KLTLALSPFAPHLAEEFWHDLGNDSLVVQQSWPSYDPKALEVEEVEIAIQINGKVRDKVV 780 Query: 781 VPVDISEEDLKRIVLERERVKEYVDGKPIRKFIYVKGRIVNIVV 824 VPVDISEEDLKRIVLERERVKEYVDGKPIRKFIYVKGRIVNIVV Sbjct: 781 VPVDISEEDLKRIVLERERVKEYVDGKPIRKFIYVKGRIVNIVV 824sp|P73274|SYL_SYNY3 LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS) >gi|1652380|dbj|BAA17302| (D90905) leucyl-tRNA synthetase [Synechocystis sp.] Length = 869 Score = 828 bits (2116), Expect = 0.0 Identities = 415/848 (48%), Positives = 537/848 (62%), Gaps = 53/848 (6%) Query: 25 TPQRSEKPKYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLP 84 TP S+ PK+YAL MFPYPSG LH+GHV+NY I D++AR KRM+GY VLHP G+DAFGLP Sbjct: 26 TPIASDLPKFYALSMFPYPSGNLHMGHVRNYTITDVIARLKRMQGYQVLHPMGWDAFGLP 85 Query: 85 AENAAIEKGIHPEEWTRKNIATIRQQVKKLGISYDWSREIATCDEEYYKWTQWIFLQLYK 144 AENAAIE+GI P++WT KNIA +R Q+++LG+S DW RE+ATC +YY+WTQW+FL+ ++ Sbjct: 86 AENAAIERGIPPKQWTEKNIAQMRAQLQQLGLSIDWEREVATCAPDYYRWTQWLFLEFFQ 145 Query: 145 NGLAYKKKAAVNWCPKCKTVLANEQV-KDGKCERCGTSVTIRHLEQWFFKITDYAERLLN 203 GLAY+K+A VNW P +TVLANEQV +G+ R G V + L QWF KITDYAE LLN Sbjct: 146 AGLAYQKEATVNWDPIDQTVLANEQVDSEGRSWRSGAMVERKLLRQWFLKITDYAEALLN 205 Query: 204 DLDKLTGWPEHVKTMQRNWIGKSTGAEIDFPVEGSDTKIRVFTTRPDTLWGVTFMXXXXX 263 DL++LTGWPE VK MQ +WIGKS GA ++FP++ S KI VFTTRPDT++GVT++ Sbjct: 206 DLEQLTGWPERVKLMQSHWIGKSVGAYLEFPIKDSQEKIAVFTTRPDTVYGVTYVVLAPE 265 Query: 264 XXXXXXXXXXXXXXXXXXXXXRVKQQDRFRRTSVEAEKEGFFLGRYAINPVTGERIPIYV 323 V ++ RT+ + K G G AINP GE IPI + Sbjct: 266 HPLTKVVTTAEQQGTVDEFVAMVAKESEIERTAEDKPKRGVKTGGIAINPFNGEEIPILI 325 Query: 324 ANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPIKVVIKPADKDLDPEKMEEAYEGEGIM 383 A+Y+L EYGTGA+MGVPAHDQRDF FA+ +P++VVI P D D + AY G+M Sbjct: 326 ADYVLYEYGTGAVMGVPAHDQRDFKFAQDNNLPMQVVIIPDDADNSDVNLTVAYTEAGVM 385 Query: 384 VNSGPFDGTPSSEGIEKVINWLEEKGIGKRSVQYKLRDWLISRQRYWGAPIPIIYCEKCG 443 VNS F G S + + +I + E+ G+ VQY+LRDWLISRQRYWG PIPII+C+ CG Sbjct: 386 VNSAQFTGMASPKAKQAIIKFAEDNDYGRAKVQYRLRDWLISRQRYWGCPIPIIHCDDCG 445 Query: 444 VVPVPEEDLPVRLPKDVEFLPTGQSPLSFHEGFKKTKCPVCGGEAQRETDTMDTFVDSSW 503 VPVP +DLPV LP +VEF G SPL+ E + CP CG A+RETDTMDTF+DSSW Sbjct: 446 AVPVPTKDLPVELPDNVEFSGRGPSPLAKLEDWINVPCPSCGKPARRETDTMDTFIDSSW 505 Query: 504 YFLRYVNPHLEDKPFEPDDVNYWLPVDQYIGGVEHAVLHLLYSRFVTKVLHDLGYLNFDE 563 YFLRY + + PF+ + V +WLPVDQY+GG+EHA+LHLLYSRF TKVL D + E Sbjct: 506 YFLRYADAQNTELPFDGEKVAHWLPVDQYVGGIEHAILHLLYSRFFTKVLADRQLIPVKE 565 Query: 564 PFTNLFTQGMI----YKDGA------------------------------------KMSK 583 PF L TQGM+ YK+ KMSK Sbjct: 566 PFQKLLTQGMVQGITYKNPTTGKYVPAKDLQTGQQVIDPKDPKDPDSGEPLQVFYEKMSK 625 Query: 584 SKGNVVSPDEMIEKYGADTLRMYILFMAPPEKDAEWSDAGIEGVHRFVKRLWN--TFYTV 641 SK N V P E++ KYGADT RM+ILF APPEKD EW DA +EG RF+ R+W T Y Sbjct: 626 SKFNGVDPQEVLAKYGADTARMFILFKAPPEKDLEWDDADVEGQFRFLNRVWRLVTDYIG 685 Query: 642 LP-----FVKEENTENLVLKNSTEKELRRKLHSIIKKITEDIEGGFKFNTAISGLMELVN 696 P V+ E EK+LRR +H IK++ ED+ ++FNTAIS +M+L N Sbjct: 686 DPAGIRFAVRPETLVTNEPLTKAEKDLRRAIHGAIKEVAEDLNDDYQFNTAISEMMKLSN 745 Query: 697 HLSQYLNSVPQEEWNRKLLREIVEKLTLALSPFAPHLAEEFWHDLGNDSLVVQQSWPSYD 756 L + + + + +E +E L L L+PFAPHL EE WH LG + QQ+W D Sbjct: 746 ALIAATDLI-----SFPVYQEGIETLLLLLAPFAPHLTEELWHRLGRTDSIHQQAWLQVD 800 Query: 757 PKALEVEEVEIAIQINGKVRDKVVVPVDISEEDLKRIVLERERVKEYVDGKPIRKFIYVK 816 P AL ++E+ + IQ+ GK R + VP + L+ + + + Y++GK I+K I V Sbjct: 801 PTALVLDEITLVIQVLGKTRGTITVPASADKTQLEELARNSDLAQRYLEGKTIKKVIVVP 860 Query: 817 GRIVNIVV 824 G++VN V+ Sbjct: 861 GKLVNFVI 868sp|P36430|SYL_BACSU LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS) >gi|2293181 (AF008220) leucine tRNA synthetase [Bacillus subtilis] >gi|2635516|emb|CAB15010| (Z99119) leucyl-tRNA synthetase [Bacillus subtilis] Length = 804 Score = 762 bits (1947), Expect = 0.0 Identities = 384/805 (47%), Positives = 510/805 (62%), Gaps = 28/805 (3%) Query: 23 FYTPQRSEKPKYYALVMFPYPSGT-LHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAF 81 F T +EK K+YAL MFPYPSG LHVGH + Y DI++R KRM+GY+VLHP G+DAF Sbjct: 22 FATLDNNEKQKFYALDMFPYPSGAGLHVGHPEGYTATDILSRMKRMQGYDVLHPMGWDAF 81 Query: 82 GLPAENAAIEKGIHPEEWTRKNIATIRQQVKKLGISYDWSREIATCDEEYYKWTQWIFLQ 141 GLPAE A++ G P +T++NI R+Q++ LG SYDW REI T D EYYKWTQWIFL+ Sbjct: 82 GLPAEQYALDTGNDPAVFTKQNIDNFRRQIQALGFSYDWDREINTTDPEYYKWTQWIFLK 141 Query: 142 LYKNGLAYKKKAAVNWCPKCKTVLANEQVKDGKCERCGTSVTIRHLEQWFFKITDYAERL 201 LY+ GLAY + VNWCP TVLANE+V DGK ER G V R ++QW KIT YA+RL Sbjct: 142 LYEKGLAYVDEVPVNWCPALGTVLANEEVIDGKSERGGHPVERRPMKQWMLKITAYADRL 201 Query: 202 LNDLDKLTGWPEHVKTMQRNWIGKSTGAEIDFPVEGSDTKIRVFTTRPDTLWGVTFMXXX 261 L DL++L WPE +K MQRNWIG+S GA + F ++G D VFTTRPDTL+G T+ Sbjct: 202 LEDLEEL-DWPESIKDMQRNWIGRSEGAHVHFAIDGHDDSFTVFTTRPDTLFGATYTVLA 260 Query: 262 XXXXXXXXXXXXXXXXXXXXXXXRVKQQDRFRRTSVEAEKEGFFLGRYAINPVTGERIPI 321 ++ + RT + K G F G YAINPV GE++PI Sbjct: 261 PEHALVENITTAEQKEAVEAYIKEIQSKSDLERTDLAKTKTGVFTGAYAINPVNGEKLPI 320 Query: 322 YVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPIKVVIKPADKDLDPEKMEEAYEGEG 381 ++A+Y+L YGTGA+M VP HD+RDF FAK +G+P+K V+K + + E AY G+G Sbjct: 321 WIADYVLASYGTGAVMAVPGHDERDFEFAKTFGLPVKEVVKGGNVE------EAAYTGDG 374 Query: 382 IMVNSGPFDGTPSSEGIEKVINWLEEKGIGKRSVQYKLRDWLISRQRYWGAPIPIIYCEK 441 VNS +G E IEKVI WLEE G++ V Y+LRDWL SRQRYWG PIP+I+ E Sbjct: 375 EHVNSDFLNGLHKQEAIEKVIAWLEETKNGEKKVTYRLRDWLFSRQRYWGEPIPVIHWED 434 Query: 442 CGVVPVPEEDLPVRLPKDVEFLP--TGQSPLSFHEGFKKTKCPVCGGEAQRETDTMDTFV 499 VPEE+LP+ LPK E P TG+SPL+ + + + P G + +RET+TM + Sbjct: 435 GTSTAVPEEELPLILPKTDEIKPSGTGESPLANIKEWVEVTDPETGKKGRRETNTMPQWA 494 Query: 500 DSSWYFLRYVNPHLEDKPFEPDDVNYWLPVDQYIGGVEHAVLHLLYSRFVTKVLHDLGYL 559 S WYFLRY++PH D+ P+ + WLPVD YIGG EHAVLHLLY+RF K L+D+G + Sbjct: 495 GSCWYFLRYIDPHNPDQLASPEKLEKWLPVDMYIGGAEHAVLHLLYARFWHKFLYDIGVV 554 Query: 560 NFDEPFTNLFTQGMIY-KDGAKMSKSKGNVVSPDEMIEKYGADTLRMYILFMAPPEKDAE 618 EPF L+ QGMI ++ KMSKSKGNVV+PDE++ +GADTLR+Y +FM P + Sbjct: 555 PTKEPFQKLYNQGMILGENNEKMSKSKGNVVNPDEIVASHGADTLRLYEMFMGPLDASIA 614 Query: 619 WSDAGIEGVHRFVKRLWNTFYTVLPFVKEENTENLVLKNSTEKELRRKLHSIIKKITEDI 678 WS++G++G RF+ R+W F+++ N + + L R H + K+T+ Sbjct: 615 WSESGLDGARRFLDRVWRL------FIEDSGELNGKIVEGAGETLERVYHETVMKVTDHY 668 Query: 679 EGGFKFNTAISGLMELVNHLSQYLNSVPQEEWNRKLLREIVEKLTLALSPFAPHLAEEFW 738 E G +FNT IS LM +N + +L +E +E LSP APHLAEE W Sbjct: 669 E-GLRFNTGISQLMVFINEAYK----------ATELPKEYMEGFVKLLSPVAPHLAEELW 717 Query: 739 HDLGNDSLVVQQSWPSYDPKALEVEEVEIAIQINGKVRDKVVVPVDISEEDLKRIVLERE 798 LG+ + ++WP YD L +EVEI +Q+NGKV+ K+ VP D ++E L+++ E Sbjct: 718 EKLGHSGTIAYEAWPVYDETKLVDDEVEIVVQLNGKVKAKLQVPADATKEQLEQLAQADE 777 Query: 799 RVKEYVDGKPIRKFIYVKGRIVNIV 823 +VKE ++GK IRK I V G++VNIV Sbjct: 778 KVKEQLEGKTIRKIIAVPGKLVNIV 802gb|AAF11720.1|AE002050_6 (AE002050) leucyl-tRNA synthetase [Deinococcus radiodurans] Length = 874 Score = 762 bits (1945), Expect = 0.0 Identities = 383/794 (48%), Positives = 499/794 (62%), Gaps = 22/794 (2%) Query: 33 KYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAENAAIEK 92 K+YAL MFPYPSG LH+GH V D AR+ RMRGYNVL P +DAFGLPAENAAI+ Sbjct: 98 KFYALTMFPYPSGNLHIGHWYANVAPDARARWLRMRGYNVLFPMAFDAFGLPAENAAIKN 157 Query: 93 GIHPEEWTRKNIATIRQQVKKLGISYDWSREIATCDEEYYKWTQWIFLQLYKNGLAYKKK 152 +P WT NI + Q ++G DWSR+ ATCD EYY+W QW F++ +K GLAYKK Sbjct: 158 NTNPATWTYANIERMTGQFSRMGTMIDWSRKFATCDPEYYRWNQWFFIEFWKRGLAYKKG 217 Query: 153 AAVNWCPKCKTVLANEQVKDGKCERCGTSVTIRHLEQWFFKITDYAERLLNDLDKLTGWP 212 VNWCPK +TVLANEQV +G CERCGT+V R+L QW+ KITDYAE LL+ T P Sbjct: 218 GLVNWCPKDQTVLANEQVVNGHCERCGTAVERRNLSQWYLKITDYAEELLD--FSATDMP 275 Query: 213 EHVKTMQRNWIGKSTGAEIDFPV-EGSDTKIRVFTTRPDTLWGVTFMXXXXXXXXXXXXX 271 E V+ MQ NWIGKS GAE+ F G +T VFTTRPDTL G TFM Sbjct: 276 EKVRAMQTNWIGKSVGAEVTFDTPAGPET---VFTTRPDTLMGATFMVLAPEHAKVKELT 332 Query: 272 XXXXXXXXXXXXXRVKQQDRFRRTSVEAEKEGFFLGRYAINPVTGERIPIYVANYILMEY 331 ++ R E EK G F G YA +P++G ++PI+VA+Y+L+ Y Sbjct: 333 TDEQRAEVEAYVAAAGRKTDVERQQ-EGEKTGVFTGSYATHPISGHQLPIWVADYVLVTY 391 Query: 332 GTGAIMGVPAHDQRDFSFAKKYGIPIKVVIKPADKDLDPEKMEEAYEGEGIMVNSGPFDG 391 GTG+IM VPAHD+RDF+FAKK+ +PI+ VI+ + ++ E Y GEG +VNSG FDG Sbjct: 392 GTGSIMAVPAHDERDFAFAKKFDLPIREVIRAEGSEGMGDQPSEPYSGEGQIVNSGEFDG 451 Query: 392 TPSSE-GIEKVINWLEEKGIGKRSVQYKLRDWLISRQRYWGAPIPIIYCEKCGVVPVPEE 450 P + I +I LEE+G+ K Y+LRDWL +RQRYWG PIP ++CEKCG+ PVPE+ Sbjct: 452 MPGGKASIAAIIARLEERGVAKAKTTYRLRDWLFARQRYWGTPIPFVHCEKCGMQPVPED 511 Query: 451 DLPVRLPKDVEFLPTGQSPLSFHEGFKKTKCPVCGGEAQRETDTMDTFVDSSWYFLRYVN 510 LPV+LP++V F PTGQSPL E +K T CP CGG A+RETDTMDTFVDSSWY RY++ Sbjct: 512 QLPVKLPENVAFTPTGQSPLKLDEEWKTTTCPCCGGPAERETDTMDTFVDSSWYMYRYLS 571 Query: 511 PHLEDKPFEPDDVNYWLPVDQYIGGVEHAVLHLLYSRFVTKVLHDLGYLNFDEPFTNLFT 570 P+ + PF+P LPVD Y GG+EHA+LHLLYSRF TKV+ D+G EPF L Sbjct: 572 PNYDGGPFDPSKAGL-LPVDLYTGGIEHAILHLLYSRFWTKVMRDMGLTTQSEPFARLRN 630 Query: 571 QGMIY-KDGAKMSKSKGNVVSPDEMIEKYGADTLRMYILFMAPPEKDAEWSDAGIEGVHR 629 QGM+ +DG KMSKS+GNVV PD+++ +YGADT+R +++F+AP E W GI G + Sbjct: 631 QGMVLGEDGEKMSKSRGNVVDPDDLVREYGADTVRAFLMFIAPWELGGPWDPQGINGPSK 690 Query: 630 FVKRLWNTFYTVLPFVKEENTENLVLKNSTEKELRRKLHSIIKKITEDIEGGFKFNTAIS 689 ++ R+WN F+ EE + ++R +HS +KK+ +D E FNT IS Sbjct: 691 WLSRVWNVFFEEKVSGPEEKMQG--------ADVRFAVHSALKKVNDDFE-RMSFNTIIS 741 Query: 690 GLMELVNHLSQYLNSVPQEEWNRKLLREIVEKLTLALSPFAPHLAEEFWHDLGNDSLVVQ 749 LMEL N L + S + + E ++ L+P PH+AEE WH+ G V Sbjct: 742 TLMELTNALVKAKRS---PVFGTPVWEEALDIFNRMLAPVVPHIAEEIWHERGQKGSVHT 798 Query: 750 QSWPSYDPKALEVEEVEIAIQINGKVRDKVVVPVDISEEDLKRIVLERERVKEYVDGKPI 809 WP D A + V I +Q++GKVR +V + S+E+ V+++++GK + Sbjct: 799 AQWPQVDEAAAVRDTVTIGVQVSGKVRGEVSISKTASQEEALSAARAIAEVQKHLEGKTV 858 Query: 810 RKFIYVKGRIVNIV 823 K IYV GRI+NIV Sbjct: 859 VKEIYVPGRIINIV 872sp|P43827|SYL_HAEIN LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS) >gi|1074962|pir||H64102 leucine--tRNA ligase (EC 6.1.1.4) - Haemophilus influenzae (strain Rd KW20) >gi|1573943 (U32774) leucyl-tRNA synthetase (leuS) [Haemophilus influenzae Rd] Length = 861 Score = 748 bits (1911), Expect = 0.0 Identities = 380/868 (43%), Positives = 518/868 (58%), Gaps = 56/868 (6%) Query: 2 KEYRPXXXXXXXXXXXXXXXXFYTPQRSEKPKYYALVMFPYPSGTLHVGHVKNYVIGDIV 61 ++YRP F + K KYY L MFPYPSG LH+GHV+NY IGD++ Sbjct: 3 EQYRPDMIEPKVQQYWAENKVFKAIKDESKEKYYCLSMFPYPSGRLHMGHVRNYTIGDVI 62 Query: 62 ARYKRMRGYNVLHPFGYDAFGLPAENAAIEKGIHPEEWTRKNIATIRQQVKKLGISYDWS 121 +RY+RM G NVL PFG+DAFGLPAE AAI+ P +WT +NIA +++Q++ LG +DW Sbjct: 63 SRYQRMLGKNVLQPFGWDAFGLPAEGAAIKNKTAPAKWTYENIAYMKKQLQLLGFGFDWD 122 Query: 122 REIATCDEEYYKWTQWIFLQLYKNGLAYKKKAAVNWCPKCKTVLANEQVKDGKCERCGTS 181 REIATC EYYKW QW F +LYK GL YKK + VNWCP +TVLANEQV +G C RC T Sbjct: 123 REIATCKPEYYKWEQWFFTELYKKGLVYKKTSTVNWCPNDETVLANEQVHEGCCWRCDTP 182 Query: 182 VTIRHLEQWFFKITDYAERLLNDLDKLTGWPEHVKTMQRNWIGKSTGAEIDFPVEGSDTK 241 V + + QWF KITDYAE+LL LD L WP+ VKTMQRNWIG+S G EI F V ++ K Sbjct: 183 VEQKEIPQWFIKITDYAEQLLGGLDTLPQWPDMVKTMQRNWIGRSEGVEITFDVANTNEK 242 Query: 242 IRVFTTRPDTLWGVTFMXXXXXXXXXXXXXXXXXXXXXXXXXXRVKQQDRFRRTSVEAEK 301 + V+TTRPDT +GV+++ K EK Sbjct: 243 VAVYTTRPDTFYGVSYL--GIAAAHPLASLAAQNNSELAAFIQEAKNAKVAEADLATMEK 300 Query: 302 EGFFLGRYAINPVTGERIPIYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPIKVVI 361 +G G +AI+P+TG+++PI+VAN++LM YGTGA+M VPAHDQRDF FA+KY +PIK VI Sbjct: 301 KGMATGLFAIHPLTGDKLPIWVANFVLMHYGTGAVMAVPAHDQRDFEFAQKYSLPIKQVI 360 Query: 362 KP-ADKDLDPEKMEEAYEGEGIMVNSGPFDGTPSSEGIEKVINWLEEKGIGKRSVQYKLR 420 P AD+++D K +A+ G +VNS FDG + + LE+ G+GKR V Y+LR Sbjct: 361 APLADEEIDLTK--QAFVEHGKLVNSDEFDGKNFDGAFNGIADKLEKLGVGKRQVNYRLR 418 Query: 421 DWLISRQRYWGAPIPIIYCEKCGVVPVPEEDLPVRLPKDVEFLPTGQSPLSFHEGFKKTK 480 DW +SRQRYWGAPIP++ E VVP P EDLP+ LP+DV + +SP++ + KT Sbjct: 419 DWGVSRQRYWGAPIPMLTLENGDVVPAPMEDLPIILPEDV-VMDGVKSPINADPNWAKT- 476 Query: 481 CPVCGGEAQRETDTMDTFVDSSWYFLRYVNPHLEDKPFEPDDVNYWLPVDQYIGGVEHAV 540 A +ETDT DTF++SSWY+ RY P ++ + ++ NYWLPVDQYIGG+EHA Sbjct: 477 -TFNDAPALKETDTFDTFMESSWYYARYTCPQYQNGMLDAEEANYWLPVDQYIGGIEHAT 535 Query: 541 LHLLYSRFVTKVLHDLGYLNFDEPFTNLFTQGMIYKDG---------------------- 578 +HLLY RF K+L D G++ +EP L QGM+ D Sbjct: 536 MHLLYFRFFHKLLRDAGFVTSEEPADKLLCQGMVLADAFYYTSPTNERIWVSPTQVTLER 595 Query: 579 ----------------------AKMSKSKGNVVSPDEMIEKYGADTLRMYILFMAPPEKD 616 KMSKSK N + P EM+EKYGADT+R++++F +P E Sbjct: 596 DEKGRIIKATDPEGRELVHSGMTKMSKSKNNGIDPQEMVEKYGADTVRLFMMFASPAEMT 655 Query: 617 AEWSDAGIEGVHRFVKRLWNTFYTVLPFVKEENTENLVLKNSTEKELRRKLHSIIKKITE 676 EW ++G+EG RF+ R+WN Y + + + L ++ +K LRR++H I K+++ Sbjct: 656 LEWQESGVEGAKRFLGRVWNLVYQYQQNPAKTSLD-LTALSAEQKVLRREVHKTIAKVSD 714 Query: 677 DIEGGFKFNTAISGLMELVNHLSQYLNSVPQEEWNRKLLREIVEKLTLALSPFAPHLAEE 736 DI FNTAI+ +MEL+N L++ + E +R ++ E + + L P PH+ E Sbjct: 715 DIGRRQTFNTAIAAVMELMNKLTK---ASLDSEQDRAVMAEALSAVVRMLYPITPHICFE 771 Query: 737 FWHDLGNDSLVVQQSWPSYDPKALEVEEVEIAIQINGKVRDKVVVPVDISEEDLKRIVLE 796 W LGN+S + W D A+ +E I +Q+NGKVR KV V D E+ +K I Sbjct: 772 LWQALGNESAIDTAEWVKADEAAMVEDEKLIVVQVNGKVRGKVTVATDADEDTVKTIAFA 831 Query: 797 RERVKEYVDGKPIRKFIYVKGRIVNIVV 824 E VK+++D + I K IYV G+++N+VV Sbjct: 832 DENVKKFIDNQHIVKVIYVVGKLLNVVV 859pir||A41882 leucine--tRNA ligase (EC 6.1.1.4) - Bacillus subtilis >gi|143148 (M88581) transfer RNA-Leu synthetase [Bacillus subtilis] Length = 804 Score = 738 bits (1885), Expect = 0.0 Identities = 376/805 (46%), Positives = 502/805 (61%), Gaps = 28/805 (3%) Query: 23 FYTPQRSEKPKYYALVMFPYPSGT-LHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAF 81 F T +EK K+YAL MFPYPSG LHVGH + Y DI++R KRM+GY+VLHP G+DAF Sbjct: 22 FATLDNNEKQKFYALDMFPYPSGAGLHVGHPEGYTATDILSRMKRMQGYDVLHPMGWDAF 81 Query: 82 GLPAENAAIEKGIHPEEWTRKNIATIRQQVKKLGISYDWSREIATCDEEYYKWTQWIFLQ 141 GLPAE A++ G P +T++NI R+Q++ LG SYDW REI T D EYYKWTQWIFL+ Sbjct: 82 GLPAEQYALDTGNDPAVFTKQNIDNFRRQIQALGFSYDWDREINTTDPEYYKWTQWIFLK 141 Query: 142 LYKNGLAYKKKAAVNWCPKCKTVLANEQVKDGKCERCGTSVTIRHLEQWFFKITDYAERL 201 LY+ GLAY + VNWCP TVLANE+V DGK ER G V R ++QW KI YA+RL Sbjct: 142 LYEKGLAYVDEVPVNWCPALGTVLANEEVIDGKSERGGHPVERRLMKQWMLKINAYADRL 201 Query: 202 LNDLDKLTGWPEHVKTMQRNWIGKSTGAEIDFPVEGSDTKIRVFTTRPDTLWGVTFMXXX 261 L DL++L WPE +K MQRNWIG+S GA + F ++G D VFTT + + Sbjct: 202 LEDLEEL-DWPESIKDMQRNWIGRSEGAHVHFAIDGHDDSFTVFTTDQIRCLALHTLSLP 260 Query: 262 XXXXXXXXXXXXXXXXXXXXXXXRVKQQDRFRRTSVEAEKEGFFLGRYAINPVTGERIPI 321 ++ + RT + K G F G YAINPV GE++PI Sbjct: 261 RNTHWWKTSQRQSKKKLLKLIIKEIQSKSDLERTDLAKTKTGVFTGAYAINPVNGEKLPI 320 Query: 322 YVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPIKVVIKPADKDLDPEKMEEAYEGEG 381 ++A+Y+L YGTGA+M VP HD+RDF FAK +G+P+K V+K + + E AY G+G Sbjct: 321 WIADYVLASYGTGAVMAVPGHDERDFEFAKTFGLPVKEVVKGGNVE------EAAYTGDG 374 Query: 382 IMVNSGPFDGTPSSEGIEKVINWLEEKGIGKRSVQYKLRDWLISRQRYWGAPIPIIYCEK 441 VNS +G E IEKVI WLEE G++ V Y+LRDWL SRQRYWG PIP+I+ E Sbjct: 375 EHVNSDFLNGLHKQEAIEKVIAWLEETKNGEKKVTYRLRDWLFSRQRYWGEPIPVIHWED 434 Query: 442 CGVVPVPEEDLPVRLPKDVEFLP--TGQSPLSFHEGFKKTKCPVCGGEAQRETDTMDTFV 499 VPEE+LP+ LPK E P TG+SPL+ + + + P G + +RET+TM + Sbjct: 435 GTSTAVPEEELPLILPKTDEIKPSGTGESPLANIKEWVEVTDPETGKKGRRETNTMPQWA 494 Query: 500 DSSWYFLRYVNPHLEDKPFEPDDVNYWLPVDQYIGGVEHAVLHLLYSRFVTKVLHDLGYL 559 S WYFLRY++PH D+ P+ + WLPVD YIGG EHAVLHLLY+RF K L+D+G + Sbjct: 495 GSCWYFLRYIDPHNPDQLASPEKLEKWLPVDMYIGGAEHAVLHLLYARFWHKFLYDIGVV 554 Query: 560 NFDEPFTNLFTQGMIY-KDGAKMSKSKGNVVSPDEMIEKYGADTLRMYILFMAPPEKDAE 618 EPF L+ QGMI ++ KMSKSKGNVV+PDE++ +GADTLR+Y +FM P + Sbjct: 555 PTKEPFQKLYNQGMILGENNEKMSKSKGNVVNPDEIVASHGADTLRLYEMFMGPLDASIA 614 Query: 619 WSDAGIEGVHRFVKRLWNTFYTVLPFVKEENTENLVLKNSTEKELRRKLHSIIKKITEDI 678 WS++G++G RF+ R+W F+++ N + + L R H + K+T+ Sbjct: 615 WSESGLDGARRFLDRVWRL------FIEDSGELNGKIVEGAGETLERVYHETVMKVTDHY 668 Query: 679 EGGFKFNTAISGLMELVNHLSQYLNSVPQEEWNRKLLREIVEKLTLALSPFAPHLAEEFW 738 E G +FNT IS LM +N + +L +E +E LSP APHLAEE W Sbjct: 669 E-GLRFNTGISQLMVFINEAYK----------ATELPKEYMEGFVKLLSPVAPHLAEELW 717 Query: 739 HDLGNDSLVVQQSWPSYDPKALEVEEVEIAIQINGKVRDKVVVPVDISEEDLKRIVLERE 798 LG+ + ++WP YD L +EVEI +Q+NGKV+ K+ VP D ++E L+++ E Sbjct: 718 EKLGHSGTIAYEAWPVYDETKLVDDEVEIVVQLNGKVKAKLQVPADATKEQLEQLAQADE 777 Query: 799 RVKEYVDGKPIRKFIYVKGRIVNIV 823 +VKE ++GK IRK I V G++VNIV Sbjct: 778 KVKEQLEGKTIRKIIAVPGKLVNIV 802sp|P07813|SYL_ECOLI LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS) >gi|1651269|dbj|BAA35289| (D90704) Leucine-tRNA ligase (EC 6.1.1.4). [Escherichia coli] >gi|1786861 (AE000168) leucine tRNA synthetase [Escherichia coli] Length = 860 Score = 732 bits (1869), Expect = 0.0 Identities = 377/875 (43%), Positives = 508/875 (57%), Gaps = 70/875 (8%) Query: 2 KEYRPXXXXXXXXXXXXXXXXFYTPQRSEKPKYYALVMFPYPSGTLHVGHVKNYVIGDIV 61 ++YRP F + K KYY L M PYPSG LH+GHV+NY IGD++ Sbjct: 3 EQYRPEEIESKVQLHWDEKRTFEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVI 62 Query: 62 ARYKRMRGYNVLHPFGYDAFGLPAENAAIEKGIHPEEWTRKNIATIRQQVKKLGISYDWS 121 ARY+RM G NVL P G+DAFGLPAE AA++ P WT NIA ++ Q+K LG YDWS Sbjct: 63 ARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLKMLGFGYDWS 122 Query: 122 REIATCDEEYYKWTQWIFLQLYKNGLAYKKKAAVNWCPKCKTVLANEQVKDGKCERCGTS 181 RE+ATC EYY+W Q F +LYK GL YKK +AVNWCP +TVLANEQV DG C RC T Sbjct: 123 RELATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDGCCWRCDTK 182 Query: 182 VTIRHLEQWFFKITDYAERLLNDLDKLTGWPEHVKTMQRNWIGKSTGAEIDFPVEGSDTK 241 V + + QWF KIT YA+ LLNDLDKL WP+ VKTMQRNWIG+S G EI F V D Sbjct: 183 VERKEIPQWFIKITAYADELLNDLDKLDHWPDTVKTMQRNWIGRSEGVEITFNVNDYDNT 242 Query: 242 IRVFTTRPDTLWGVTFMXXXXXXXXXXXXXXXXXXXXXXXXXXRVKQQDRFRRTSV---- 297 + V+TTRPDT G T++ D R T V Sbjct: 243 LTVYTTRPDTFMGCTYLAVAAGHPLAQKAAENNPELAAFI--------DECRNTKVAEAE 294 Query: 298 --EAEKEGFFLGRYAINPVTGERIPIYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGI 355 EK+G G A++P+TGE IP++ AN++LMEYGTGA+M VP HDQRD+ FA KYG+ Sbjct: 295 MATMEKKGVDTGFKAVHPLTGEEIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGL 354 Query: 356 PIKVVIKPADKDLDPEKMEEAYEGEGIMVNSGPFDGTPSSEGIEKVINWLEEKGIGKRSV 415 IK VI AD +P+ ++A +G++ NSG F+G + + L G+G+R V Sbjct: 355 NIKPVILAADGS-EPDLSQQALTEKGVLFNSGEFNGLDHEAAFNAIADKLTAMGVGERKV 413 Query: 416 QYKLRDWLISRQRYWGAPIPIIYCEKCGVVPVPEEDLPVRLPKDVEFLPTGQSPLSFHEG 475 Y+LRDW +SRQRYWGAPIP++ E V+P P++ LPV LP+DV + SP+ Sbjct: 414 NYRLRDWGVSRQRYWGAPIPMVTLEDGTVMPTPDDQLPVILPEDV-VMDGITSPIKADPE 472 Query: 476 FKKTKCPVCGGEAQRETDTMDTFVDSSWYFLRYVNPHLEDKPFEPDDVNYWLPVDQYIGG 535 + KT V G A RETDT DTF++SSWY+ RY P ++ + + NYWLPVD YIGG Sbjct: 473 WAKT--TVNGMPALRETDTFDTFMESSWYYARYTCPQYKEGMLDSEAANYWLPVDIYIGG 530 Query: 536 VEHAVLHLLYSRFVTKVLHDLGYLNFDEPFTNLFTQGMIYKDG----------------- 578 +EHA++HLLY RF K++ D G +N DEP L QGM+ D Sbjct: 531 IEHAIMHLLYFRFFHKLMRDAGMVNSDEPAKQLLCQGMVLADAFYYVGENGERNWVSPVD 590 Query: 579 ---------------------------AKMSKSKGNVVSPDEMIEKYGADTLRMYILFMA 611 +KMSKSK N + P M+E+YGADT+R++++F + Sbjct: 591 AIVERDEKGRIVKAKDAAGHELVYTGMSKMSKSKNNGIDPQVMVERYGADTVRLFMMFAS 650 Query: 612 PPEKDAEWSDAGIEGVHRFVKRLWNTFY--TVLPFVKEENTENLVLKNSTEKELRRKLHS 669 P + EW ++G+EG +RF+KR+W Y T V N + L +K LRR +H Sbjct: 651 PADMTLEWQESGVEGANRFLKRVWKLVYEHTAKGDVAALNVDAL---TENQKALRRDVHK 707 Query: 670 IIKKITEDIEGGFKFNTAISGLMELVNHLSQYLNSVPQEEWNRKLLREIVEKLTLALSPF 729 I K+T+DI FNTAI+ +MEL+N L++ + E +R L++E + + L+PF Sbjct: 708 TIAKVTDDIGRRQTFNTAIAAIMELMNKLAK---APTDGEQDRALMQEALLAVVRMLNPF 764 Query: 730 APHLAEEFWHDLGNDSLVVQQSWPSYDPKALEVEEVEIAIQINGKVRDKVVVPVDISEED 789 PH+ W +L + + WP D KA+ + + +Q+NGKVR K+ VPVD +EE Sbjct: 765 TPHICFTLWQELKGEGDIDNAPWPVADEKAMVEDSTLVVVQVNGKVRAKITVPVDATEEQ 824 Query: 790 LKRIVLERERVKEYVDGKPIRKFIYVKGRIVNIVV 824 ++ + V +Y+DG +RK IYV G+++N+VV Sbjct: 825 VRERAGQEHLVAKYLDGVTVRKVIYVPGKLLNLVV 859gi|1778560 (U82598) leucine tRNA synthetase [Escherichia coli] Length = 907 Score = 732 bits (1868), Expect = 0.0 Identities = 377/875 (43%), Positives = 508/875 (57%), Gaps = 70/875 (8%) Query: 2 KEYRPXXXXXXXXXXXXXXXXFYTPQRSEKPKYYALVMFPYPSGTLHVGHVKNYVIGDIV 61 ++YRP F + K KYY L M PYPSG LH+GHV+NY IGD++ Sbjct: 50 EQYRPEEIESKVQLHWDEKRTFEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVI 109 Query: 62 ARYKRMRGYNVLHPFGYDAFGLPAENAAIEKGIHPEEWTRKNIATIRQQVKKLGISYDWS 121 ARY+RM G NVL P G+DAFGLPAE AA++ P WT NIA ++ Q+K LG YDWS Sbjct: 110 ARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLKMLGFGYDWS 169 Query: 122 REIATCDEEYYKWTQWIFLQLYKNGLAYKKKAAVNWCPKCKTVLANEQVKDGKCERCGTS 181 RE+ATC EYY+W Q F +LYK GL YKK +AVNWCP +TVLANEQV DG C RC T Sbjct: 170 RELATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDGCCWRCDTK 229 Query: 182 VTIRHLEQWFFKITDYAERLLNDLDKLTGWPEHVKTMQRNWIGKSTGAEIDFPVEGSDTK 241 V + + QWF KIT YA+ LLNDLDKL WP+ VKTMQRNWIG+S G EI F V D Sbjct: 230 VERKEIPQWFIKITAYADELLNDLDKLDHWPDTVKTMQRNWIGRSEGVEITFNVNDYDNT 289 Query: 242 IRVFTTRPDTLWGVTFMXXXXXXXXXXXXXXXXXXXXXXXXXXRVKQQDRFRRTSV---- 297 + V+TTRPDT G T++ D R T V Sbjct: 290 LTVYTTRPDTFMGCTYLAVRAGHPLAQKAAENNPELAAFI--------DECRNTKVAEAE 341 Query: 298 --EAEKEGFFLGRYAINPVTGERIPIYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGI 355 EK+G G A++P+TGE IP++ AN++LMEYGTGA+M VP HDQRD+ FA KYG+ Sbjct: 342 MATMEKKGVDTGFKAVHPLTGEEIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGL 401 Query: 356 PIKVVIKPADKDLDPEKMEEAYEGEGIMVNSGPFDGTPSSEGIEKVINWLEEKGIGKRSV 415 IK VI AD +P+ ++A +G++ NSG F+G + + L G+G+R V Sbjct: 402 NIKPVILAADGS-EPDLSQQALTEKGVLFNSGEFNGLDHEAAFNAIADKLTAMGVGERKV 460 Query: 416 QYKLRDWLISRQRYWGAPIPIIYCEKCGVVPVPEEDLPVRLPKDVEFLPTGQSPLSFHEG 475 Y+LRDW +SRQRYWGAPIP++ E V+P P++ LPV LP+DV + SP+ Sbjct: 461 NYRLRDWGVSRQRYWGAPIPMVTLEDGTVMPTPDDQLPVILPEDV-VMDGITSPIKADPE 519 Query: 476 FKKTKCPVCGGEAQRETDTMDTFVDSSWYFLRYVNPHLEDKPFEPDDVNYWLPVDQYIGG 535 + KT V G A RETDT DTF++SSWY+ RY P ++ + + NYWLPVD YIGG Sbjct: 520 WAKT--TVNGMPALRETDTFDTFMESSWYYARYTCPQYKEGMLDSEAANYWLPVDIYIGG 577 Query: 536 VEHAVLHLLYSRFVTKVLHDLGYLNFDEPFTNLFTQGMIYKDG----------------- 578 +EHA++HLLY RF K++ D G +N DEP L QGM+ D Sbjct: 578 IEHAIMHLLYFRFFHKLMRDAGMVNSDEPAKQLLCQGMVLADAFYYVGENGERNWVSPVD 637 Query: 579 ---------------------------AKMSKSKGNVVSPDEMIEKYGADTLRMYILFMA 611 +KMSKSK N + P M+E+YGADT+R++++F + Sbjct: 638 AIVERDEKGRIVKAKDAAGHELVYTGMSKMSKSKNNGIDPQVMVERYGADTVRLFMMFAS 697 Query: 612 PPEKDAEWSDAGIEGVHRFVKRLWNTFY--TVLPFVKEENTENLVLKNSTEKELRRKLHS 669 P + EW ++G+EG +RF+KR+W Y T V N + L +K LRR +H Sbjct: 698 PADMTLEWQESGVEGANRFLKRVWKLVYEHTAKGDVAALNVDAL---TENQKALRRDVHK 754 Query: 670 IIKKITEDIEGGFKFNTAISGLMELVNHLSQYLNSVPQEEWNRKLLREIVEKLTLALSPF 729 I K+T+DI FNTAI+ +MEL+N L++ + E +R L++E + + L+PF Sbjct: 755 TIAKVTDDIGRRQTFNTAIAAIMELMNKLAK---APTDGEQDRALMQEALLAVVRMLNPF 811 Query: 730 APHLAEEFWHDLGNDSLVVQQSWPSYDPKALEVEEVEIAIQINGKVRDKVVVPVDISEED 789 PH+ W +L + + WP D KA+ + + +Q+NGKVR K+ VPVD +EE Sbjct: 812 TPHICFTLWQELKGEGDIDNAPWPVADEKAMVEDSTLVVVQVNGKVRAKITVPVDATEEQ 871 Query: 790 LKRIVLERERVKEYVDGKPIRKFIYVKGRIVNIVV 824 ++ + V +Y+DG +RK IYV G+++N+VV Sbjct: 872 VRERAGQEHLVAKYLDGVTVRKVIYVPGKLLNLVV 906pir||SYECL leucine--tRNA ligase (EC 6.1.1.4) - Escherichia coli >gi|41916|emb|CAA29642| (X06331) leucyl-tRNA synthetase [Escherichia coli] Length = 860 Score = 728 bits (1858), Expect = 0.0 Identities = 375/875 (42%), Positives = 506/875 (56%), Gaps = 70/875 (8%) Query: 2 KEYRPXXXXXXXXXXXXXXXXFYTPQRSEKPKYYALVMFPYPSGTLHVGHVKNYVIGDIV 61 ++YRP F + K KYY L M PYPSG LH+GHV+NY IGD++ Sbjct: 3 EQYRPEEIESKVQLHWDEKRTFEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVI 62 Query: 62 ARYKRMRGYNVLHPFGYDAFGLPAENAAIEKGIHPEEWTRKNIATIRQQVKKLGISYDWS 121 ARY+ M G NVL P G+DAFGLPAE AA++ P WT NIA ++ Q+K LG YDWS Sbjct: 63 ARYQHMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLKMLGFGYDWS 122 Query: 122 REIATCDEEYYKWTQWIFLQLYKNGLAYKKKAAVNWCPKCKTVLANEQVKDGKCERCGTS 181 RE+ATC EYY+W Q F +LYK GL YKK +AVNWCP +TVLANEQV DG C RC T Sbjct: 123 RELATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDGCCWRCDTK 182 Query: 182 VTIRHLEQWFFKITDYAERLLNDLDKLTGWPEHVKTMQRNWIGKSTGAEIDFPVEGSDTK 241 V + + QWF KI YA+ LLNDLDKL WP+ VKTMQRNWIG+S G EI F V D Sbjct: 183 VERKEIPQWFIKINAYADELLNDLDKLDHWPDTVKTMQRNWIGRSEGVEITFNVNDYDNT 242 Query: 242 IRVFTTRPDTLWGVTFMXXXXXXXXXXXXXXXXXXXXXXXXXXRVKQQDRFRRTSV---- 297 + V+TTRPDT G T++ D R T V Sbjct: 243 LTVYTTRPDTFMGCTYLAVRAGHPLAQKAAENNPELAAFI--------DECRNTKVAEAE 294 Query: 298 --EAEKEGFFLGRYAINPVTGERIPIYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGI 355 EK+G G A++P+TGE IP++ AN++LMEYGTGA+M VP HDQRD+ FA KYG+ Sbjct: 295 MATMEKKGVDTGFKAVHPLTGEEIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGL 354 Query: 356 PIKVVIKPADKDLDPEKMEEAYEGEGIMVNSGPFDGTPSSEGIEKVINWLEEKGIGKRSV 415 IK VI AD +P+ ++A +G++ NSG F+G + + L G+G+R V Sbjct: 355 NIKPVILAADGS-EPDLSQQALTEKGVLFNSGEFNGLDHEAAFNAIADKLTAMGVGERKV 413 Query: 416 QYKLRDWLISRQRYWGAPIPIIYCEKCGVVPVPEEDLPVRLPKDVEFLPTGQSPLSFHEG 475 Y+LRDW +SRQRYWGAPIP++ E V+P P++ LPV LP+DV + SP+ Sbjct: 414 NYRLRDWGVSRQRYWGAPIPMVTLEDGTVMPTPDDQLPVILPEDV-VMDGITSPIKADPE 472 Query: 476 FKKTKCPVCGGEAQRETDTMDTFVDSSWYFLRYVNPHLEDKPFEPDDVNYWLPVDQYIGG 535 + KT V G A RETDT DTF++SSWY+ RY P ++ + + NYWLPVD YIGG Sbjct: 473 WAKT--TVNGMPALRETDTFDTFMESSWYYARYTCPQYKEGMLDSEAANYWLPVDIYIGG 530 Query: 536 VEHAVLHLLYSRFVTKVLHDLGYLNFDEPFTNLFTQGMIYKDG----------------- 578 +EHA++HLLY RF K++ D G +N DEP L QGM+ D Sbjct: 531 IEHAIMHLLYFRFFHKLMRDAGMVNSDEPAKQLLCQGMVLADAFYYVGENGERNWVSPVD 590 Query: 579 ---------------------------AKMSKSKGNVVSPDEMIEKYGADTLRMYILFMA 611 +KMSKSK N + P M+E+YGADT+R++++F + Sbjct: 591 AIVERDEKGRIVKAKDAAGHELVYTGMSKMSKSKNNGIDPQVMVERYGADTVRLFMMFAS 650 Query: 612 PPEKDAEWSDAGIEGVHRFVKRLWNTFY--TVLPFVKEENTENLVLKNSTEKELRRKLHS 669 P + EW ++G+EG +RF+KR+W Y T V N + L +K LRR +H Sbjct: 651 PADMTLEWQESGVEGANRFLKRVWKLVYEHTAKGDVAALNVDAL---TENQKALRRDVHK 707 Query: 670 IIKKITEDIEGGFKFNTAISGLMELVNHLSQYLNSVPQEEWNRKLLREIVEKLTLALSPF 729 I K+T+DI FNTAI+ +MEL+N L++ + E +R L++E + + L+PF Sbjct: 708 TIAKVTDDIGRRQTFNTAIAAIMELMNKLAK---APTDGEQDRALMQEALLAVVRMLNPF 764 Query: 730 APHLAEEFWHDLGNDSLVVQQSWPSYDPKALEVEEVEIAIQINGKVRDKVVVPVDISEED 789 PH+ W +L + + WP D KA+ + + +Q+NGKVR K+ VPVD +EE Sbjct: 765 TPHICFTLWQELKGEGDIDNAPWPVADEKAMVEDSTLVVVQVNGKVRAKITVPVDATEEQ 824 Query: 790 LKRIVLERERVKEYVDGKPIRKFIYVKGRIVNIVV 824 ++ + V +Y+DG +RK IYV G+++N+VV Sbjct: 825 VRERAGQEHLVAKYLDGVTVRKVIYVPGKLLNLVV 859gi|4156066 (AE001567) LEUCYL-TRNA SYNTHETASE [Helicobacter pylori J99] Length = 806 Score = 695 bits (1774), Expect = 0.0 Identities = 363/807 (44%), Positives = 511/807 (62%), Gaps = 46/807 (5%) Query: 32 PKYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAENAAIE 91 PK Y L M PYPSG +H+GHV+NY IGD +ARY R+ YNVLHP G+D+FG+PAENAAI+ Sbjct: 29 PKKYILSMLPYPSGEIHMGHVRNYTIGDALARYYRLHHYNVLHPMGFDSFGMPAENAAIK 88 Query: 92 KGIHPEEWTRKNIATIRQQVKKLGISYDWSREIATCDEEYYKWTQWIFLQLYKNGLAYKK 151 GIHP+ WT +NI ++++ + LG S+ +RE AT D +Y K+ Q F+ L++ GL Y+K Sbjct: 89 HGIHPKTWTYENIEAMQKEFEALGFSFSKNREFATSDPDYTKFEQQFFIDLWEKGLIYRK 148 Query: 152 KAAVNWCPKCKTVLANEQVKDGKCERCGTSVTIRHLEQWFFKITDYAERLLNDLDKLTG- 210 KA +NWCP KTVLANEQV DG+C RC T V + L Q++ KIT+YAE LL DL+ L Sbjct: 149 KAMLNWCPNDKTVLANEQVIDGRCWRCDTEVIQKELYQYYLKITNYAEELLKDLETLENH 208 Query: 211 WPEHVKTMQRNWIGKSTGAEIDFPVEGSDTK-------IRVFTTRPDTLWGVTFMXXXXX 263 WP V TMQ+NWIGKS+G + F + K I VFTTR DT++GVT++ Sbjct: 209 WPSQVLTMQKNWIGKSSGLQFGFKIADECLKACNNIQEIEVFTTRADTIYGVTYIAIAPE 268 Query: 264 XXXXXXXXXXXXXXXXXXXXXRVKQQDRFRRTSVEAEKEGFFLGRYAINPVTGERIPIYV 323 + R R EK+G FLG YAI+P+T ++IP++V Sbjct: 269 HPLVEHAIKRVSQEDSKMIKAILNTTQRER----ALEKKGAFLGIYAIHPLTKQKIPVWV 324 Query: 324 ANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPIKVVIKPADKDLDPEKMEEAYEGEGIM 383 AN+ L YG+GA+MGVPA D+RDF FA Y IPIKV+ + P+ + + E I+ Sbjct: 325 ANFALANYGSGALMGVPACDERDFEFANLYHIPIKVITQ------SPQNL--PHTKEEIL 376 Query: 384 VNSGPFDGTPSSEGIEKVINWLEEKGIGKRSVQYKLRDWLISRQRYWGAPIPIIYCEKCG 443 NSG + SS EK+I + E++ +GKR + Y+L+DW +SRQRYWGAPIP+I+C+ CG Sbjct: 377 KNSGEWSDLSSSVAREKIIAYFEKENLGKRVINYRLQDWGVSRQRYWGAPIPMIHCKHCG 436 Query: 444 VVPVPEEDLPVRLPKDVEFLPTGQSPLSFHEGFKKTKCPVCGGEAQRETDTMDTFVDSSW 503 + VPE LPV LP+D+ G +PL H +K +CP C +A RETDTMDTF+ SSW Sbjct: 437 I--VPETQLPVTLPEDIVIDGEG-NPLEKHASWKFAQCPKCHKDALRETDTMDTFIQSSW 493 Query: 504 YFLRYVNP--HLEDKPFEPDDVNYWLPVDQYIGGVEHAVLHLLYSRFVTKVLHDLGYLNF 561 YFLRY P E++ F+ + + Y++PVD YIGG+EHA+LHLLY+RF TK L DLGYL+ Sbjct: 494 YFLRYTTPKNQRENQAFDQNYLKYFMPVDTYIGGIEHAILHLLYARFFTKALRDLGYLHL 553 Query: 562 DEPFTNLFTQGMIYKDGAKMSKSKGNVVSPDEMIEKYGADTLRMYILFMAPPEKDAEWSD 621 DEPF L TQGM+ KDGAKMSKSKGNVVSP E+++KYGAD +R++ILF APP K+ EW+D Sbjct: 554 DEPFKQLITQGMVLKDGAKMSKSKGNVVSPKEILKKYGADAVRLFILFAAPPAKELEWND 613 Query: 622 AGIEGVHRFVKRLWNTFYTVLPFVKEENTENLVLKNSTEKELRRKLHSIIKK---ITEDI 678 +EG HRF+KRL++ + P + + + L N +K R+K++ +KK I Sbjct: 614 NALEGAHRFIKRLYDKANAITPTTSKPEFKEVGL-NEAQKLARKKVYEALKKSHEIFNKA 672 Query: 679 EGGFKFNTAISGLMELVNHLSQYLNSVPQEEWNRKLLREIVEKLTLALSPFAPHLAEEFW 738 E + FNT I+ ME +N L+ + + ++L E L L P PH A E Sbjct: 673 ESAYAFNTLIASCMEALNALN--------AQSDEQILCEGYFVLLQILEPMIPHTAWEL- 723 Query: 739 HDLGNDSLVVQQSWP--SYDPKALEVEEVEIAIQINGKVRDKVVVPVDISEEDLKRIVLE 796 ++ L ++++ D AL + + + + INGK R ++ V ++ S+E++ I+L Sbjct: 724 ----SERLFKRENFKPIEVDESALIEDFMTLGLTINGKRRAELKVNINASKEEI--IILA 777 Query: 797 RERVKEYVDGKPIRKFIYVKGRIVNIV 823 ++ +++Y++ ++K IYV ++VN V Sbjct: 778 KKELEKYLENASVKKEIYVPNKLVNFV 804gi|2688147 (AE001135) leucyl-tRNA synthetase (leuS) [Borrelia burgdorferi] Length = 840 Score = 695 bits (1773), Expect = 0.0 Identities = 373/842 (44%), Positives = 504/842 (59%), Gaps = 74/842 (8%) Query: 26 PQRSEKPKYYALVMFPYPSGT-LHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLP 84 P ++ + Y L MFPYPS LHVGH + Y DI RYK + G++VLHP G+D+FGLP Sbjct: 29 PSIPKEKRLYILDMFPYPSANGLHVGHPEGYTATDIFGRYKLLNGFHVLHPIGFDSFGLP 88 Query: 85 AENAAIEKGIHPEEWTRKNIATIRQQVKKLGISYDWSREIATCDEEYYKWTQWIFLQLYK 144 AEN AI+ G HP++ T +NI ++Q+K LG +YDW REI T +E YYKWTQWIFLQLYK Sbjct: 89 AENYAIQTGTHPQKSTEENINKFKKQIKALGFAYDWDREIRTHEENYYKWTQWIFLQLYK 148 Query: 145 NGLAYKKKAAVNWCPKCKTVLANE---QVKDG-KCERCGTSVTIRHLEQWFFKITDYAER 200 GLAY K+ V +CP+ TVLANE Q DG K ER SV ++L QW KIT YAER Sbjct: 149 KGLAYVKEMPVWYCPELGTVLANEEIIQTSDGPKSERGSYSVEKKYLRQWVLKITKYAER 208 Query: 201 LLNDLDKLTGWPEHVKTMQRNWIGKSTGAEIDFPVEGSDTKIRVFTTRPDTLWGVTFMXX 260 LL+DL++L WPE VK MQRNWIGKSTG EI+F +EG KI+VFTTRPDT++G+T++ Sbjct: 209 LLDDLEELE-WPESVKEMQRNWIGKSTGVEIEFEIEGHSDKIKVFTTRPDTIFGITYLVI 267 Query: 261 XXXXXXXXXXXXXXXXXXXXXXXXRVKQQDRFRRTSVEAEKEGFFLGRYAINPVTGERIP 320 + + RTS+E +K G F G YA +P+T E+IP Sbjct: 268 APENKLIEKITKNNFKQNVLKYVKHEELKSDLNRTSLEKDKSGVFTGSYAFHPITNEKIP 327 Query: 321 IYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPIKVVIKPADKDLDPEKMEEAYEGE 380 I+V +Y+L YGTGA+MGVPAHD+RDF FAKKY + I VI + K+ E +E+A+ + Sbjct: 328 IWVGSYVLGTYGTGAVMGVPAHDERDFQFAKKYQLKILPVISKSGKN---EILEKAFVDD 384 Query: 381 GIMVNS-GPFDGTPSSEGIEKVINWLEEKGIGKRSVQYKLRDWLISRQRYWGAPIPIIYC 439 GI +NS F+ +SE +KVI WL + GK V YKLRDW+ SRQRYWG PIPI++ Sbjct: 385 GISINSPNEFNNLKNSEVKDKVIKWLTKNKKGKEKVAYKLRDWIFSRQRYWGEPIPILFD 444 Query: 440 EKCGVVPVPEEDLPVRLPKDVEFLP--TGQSPLSFHEGFKKTKCPVCGGEAQRETDTMDT 497 + +P+ E DLP++LP+ + P TG+SPLS + + K RET+TM Sbjct: 445 KLGNAIPLEENDLPLKLPEIANYKPSGTGESPLSRIKDWVNVK----DMGFTRETNTMPQ 500 Query: 498 FVDSSWYFLRYVNPHLEDKPFEPDDVNYWLPVDQYIGGVEHAVLHLLYSRFVTKVLHDLG 557 + S WY+LRY++P + + YW+PVD YIGG EH VLHLLYSRF KVL+DLG Sbjct: 501 WAGSCWYYLRYLDPKNSKEFANKKKIEYWMPVDLYIGGAEHTVLHLLYSRFWHKVLYDLG 560 Query: 558 YLNFDEPFTNLFTQG-------------------MIYKDG---------------AKMSK 583 Y+N EPF L QG +I KD AKMSK Sbjct: 561 YVNTKEPFKKLINQGIITSFSYQKENGVLIPNDQVIEKDNKFFDKKDNKEVTQVIAKMSK 620 Query: 584 SKGNVVSPDEMIEKYGADTLRMYILFMAPPEKDAEWSDAGIEGVHRFVKRLWNTFYTVLP 643 S NV++PD++I+++GAD++R+Y +FM P W+ GI GV RF+ ++WN Sbjct: 621 SLKNVINPDDIIKEFGADSMRIYEMFMGPLTDSKPWNTKGIIGVFRFLNKIWNL------ 674 Query: 644 FVKEENTENLVLKNSTEKELRRKLHSIIKKITEDIEGGFKFNTAISGLMELVNHLSQYLN 703 E + K + +E+ +LH +IKK+TED E FNTAIS +M +N L +Y Sbjct: 675 ------REKELSKENPPREIISELHKVIKKVTEDTE-KLNFNTAISAMMIFINELLKY-- 725 Query: 704 SVPQEEWNRKLLREIVEKLTLALSPFAPHLAEEFWHDLGN-DSLVVQQSWPSYDPKALEV 762 K I + + LSP+APHLAEE W +G SL WP +D + Sbjct: 726 --------EKNYLNIFKPFIIILSPYAPHLAEELWEYIGELPSLFKNSKWPKFDESLIIK 777 Query: 763 EEVEIAIQINGKVRDKVVVPVDISEEDLKRIVLERERVKEYVDGKPIRKFIYVKGRIVNI 822 + EI +QINGK++DK+++ + E++LK I +E ++K + K I K I +K ++VNI Sbjct: 778 GKKEIVLQINGKIKDKILLNKETGEKELKEIAMENSKIKSNLLNKKIVKIIVIKNKLVNI 837 Query: 823 VV 824 V+ Sbjct: 838 VI 839sp|O83595|SYL_TREPA LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS) >gi|3322882 (AE001234) leucyl-tRNA synthetase (leuS) [Treponema pallidum] Length = 878 Score = 693 bits (1769), Expect = 0.0 Identities = 363/862 (42%), Positives = 491/862 (56%), Gaps = 74/862 (8%) Query: 24 YTPQRSEKPKYYALVMFPYPSGT-LHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFG 82 + P+R + Y L MFPYPS LHVGH + Y DI RY RM GYNVLHP G+DAFG Sbjct: 30 FPPER----RAYVLDMFPYPSAQGLHVGHPEGYTATDIYCRYLRMGGYNVLHPMGFDAFG 85 Query: 83 LPAENAAIEKGIHPEEWTRKNIATIRQQVKKLGISYDWSREIATCDEEYYKWTQWIFLQL 142 LPAEN A++ G HP T N T R+Q++ G SYDW REI+T D EYY+WTQW+FL+L Sbjct: 86 LPAENFALKTGTHPRVSTSANCDTFRRQIQSFGFSYDWEREISTADPEYYRWTQWLFLKL 145 Query: 143 YKNGLAYKKKAAVNWCPKCKTVLANEQVKDGKCERCGTSVTIRHLEQWFFKITDYAERLL 202 Y+ GLAY+ A +NWCP CKT LANE+V+D CERCG VT R + QW +IT YAERLL Sbjct: 146 YEKGLAYEATAPINWCPSCKTGLANEEVRDACCERCGAEVTRRGVRQWMVRITAYAERLL 205 Query: 203 NDLDKLTGWPEHVKTMQRNWIGKSTGAEIDFPVEGSDTK--------IRVFTTRPDTLWG 254 +DLD+L WPE VK MQRNWIGKS GAEIDFPV+ IRV+TTR DTL+G Sbjct: 206 SDLDELD-WPESVKQMQRNWIGKSCGAEIDFPVDAPACSVHDKLPQTIRVYTTRADTLFG 264 Query: 255 VTFMXXXXXXXXXXXXXXXXXXXXXXXXXXRVKQQDRFRRTSVEAEKEGFFLGRYAINPV 314 VT++ R +++ RT + EK G F G Y NP+ Sbjct: 265 VTYLVLAPEHEAVTALTTHAQRAAVQAYVQRAAKKNDLERTDLAKEKTGVFTGAYVRNPI 324 Query: 315 TGERIPIYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPIKVVIK-------PADKD 367 RIP++V +Y+L+ YGTGA+M VPAHDQRD+ FA ++G+P V+ P Sbjct: 325 NDMRIPVWVGDYVLVSYGTGAVMAVPAHDQRDWDFATRFGLPKLTVVSADYTATVPNSNS 384 Query: 368 LDPEKMEEAYEGEGIMVNSGPFDGTPSSEGIEKVINWLEEKGIGKRSVQYKLRDWLISRQ 427 ++ EG +VNSG F+G S++ E+++ LE +G G R V Y+LRDW+ SRQ Sbjct: 385 PQGAVLQRCVSDEGFVVNSGAFNGLASADARERIVAHLEMRGAGARRVTYRLRDWVFSRQ 444 Query: 428 RYWGAPIPIIYCEKCGVVPVPEEDLPVRLPKDVEFLPT--GQSPLSFHEGFKKTKCPVCG 485 RYWG PIP+++C CGVVP+PE LP+ LP+ +F PT GQ PL+ + + CP C Sbjct: 445 RYWGEPIPLVHCPSCGVVPLPESALPLLLPETADFTPTEDGQGPLARARTWLRVPCPQCA 504 Query: 486 GEAQRETDTMDTFVDSSWYFLRYVNPHLEDKPFEPDDVNYWLPVDQYIGGVEHAVLHLLY 545 +A RET+TM + S WY+LRY++P + P+ YW PV Y+GG EHAVLHLLY Sbjct: 505 SDAVRETNTMPQWAGSCWYYLRYMDPRNKTAFCAPEKERYWAPVALYVGGAEHAVLHLLY 564 Query: 546 SRFVTKVLHDLGYLNFDEPFTNLFTQGMIY------KDGA-------------------- 579 +RF KVL+DLG ++ EPF L QGMI K+GA Sbjct: 565 ARFWHKVLYDLGLVSTKEPFARLVNQGMITSYAYRRKNGALVPHDEVHTNAQGTYVHART 624 Query: 580 ---------KMSKSKGNVVSPDEMIEKYGADTLRMYILFMAPPEKDAEWSDAGIEGVHRF 630 KMSK+ NVV+PD+MI YGAD R+Y +FM P E W+ G+ GV RF Sbjct: 625 GEKLECVVAKMSKALKNVVNPDDMIAAYGADACRVYEMFMGPLEASKPWNTQGLVGVFRF 684 Query: 631 VKRLWNTFYTVLP---FVKEENTE-----NLVLKNSTEKELRRKLHSIIKKITEDIEGGF 682 ++++W V ++ E + K+ + L LH I+K+T+D Sbjct: 685 LEKIWVLAGRVAAANGIPQDSRAEPPGDLHAQKKSCSMYALETLLHRTIQKVTDDTSA-L 743 Query: 683 KFNTAISGLMELVNHLSQYLNSVPQEEWNRKLLREIVEKLTLALSPFAPHLAEEFWHDLG 742 FNTAIS +M VN ++ +P L ++ E LSP+APHLAEE W G Sbjct: 744 SFNTAISQMMIFVNEATRVARRMP-------LPSKMWEMFVKILSPYAPHLAEELWEMCG 796 Query: 743 NDSLVVQQSWPSYDPKALEVEEVEIAIQINGKVRDKVVVPVDISEEDLKRIVLERERVKE 802 + + + WP DP + + +Q+NGKVRD V + E+L++ E ++ Sbjct: 797 HTHTIAYEPWPQVDPARVAPHVCSVVVQVNGKVRDTFSVAPNAPNEELEQKARETAGARK 856 Query: 803 YVDGKPIRKFIYVKGRIVNIVV 824 ++ + ++ + V ++VN V+ Sbjct: 857 FLGTQQPKRVVIVPNKLVNFVL 878sp|P56457|SYL_HELPY LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS) >gi|2314727|gb|AAD08585.1| (AE000652) leucyl-tRNA synthetase (leuS) [Helicobacter pylori 26695] Length = 806 Score = 693 bits (1769), Expect = 0.0 Identities = 363/808 (44%), Positives = 511/808 (62%), Gaps = 46/808 (5%) Query: 32 PKYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAENAAIE 91 PK Y L M PYPSG +H+GHV+NY IGD +ARY R+ YNVLHP G+D+FG+PAENAAI+ Sbjct: 29 PKKYILSMLPYPSGEIHMGHVRNYTIGDALARYYRLHHYNVLHPMGFDSFGMPAENAAIK 88 Query: 92 KGIHPEEWTRKNIATIRQQVKKLGISYDWSREIATCDEEYYKWTQWIFLQLYKNGLAYKK 151 GIHP+ WT +NI ++++ + LG S+ +RE AT D +Y K+ Q F+ L++ GL Y+K Sbjct: 89 HGIHPKTWTYENIENMQKEFEALGFSFSKNREFATSDPDYTKFEQRFFIDLWEKGLIYRK 148 Query: 152 KAAVNWCPKCKTVLANEQVKDGKCERCGTSVTIRHLEQWFFKITDYAERLLNDLDKLTG- 210 KA +NWCP KTVLANEQV DG+C RC T V + L Q++ KIT+YAE LL DL+ L Sbjct: 149 KAMLNWCPNDKTVLANEQVIDGRCWRCDTEVIQKELYQYYLKITNYAEELLKDLEALEDH 208 Query: 211 WPEHVKTMQRNWIGKSTGAEIDFPVEGSDTK-------IRVFTTRPDTLWGVTFMXXXXX 263 WP V MQ+NWIGKS+G + F + K I VFTTR DT++GVT++ Sbjct: 209 WPSQVLIMQKNWIGKSSGLQFGFKIADECLKACNGIQEIEVFTTRADTIYGVTYIAIAPE 268 Query: 264 XXXXXXXXXXXXXXXXXXXXXRVKQQDRFRRTSVEAEKEGFFLGRYAINPVTGERIPIYV 323 + R R EK+G FLG YAI+P+T ++IP++V Sbjct: 269 HPLVEHAIKQVSQEVSKMIKAILNTTQRER----ALEKKGAFLGIYAIHPLTKQKIPVWV 324 Query: 324 ANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPIKVVIKPADKDLDPEKMEEAYEGEGIM 383 AN+ L YG+GA+MGVPA D+RDF FA Y IPIKV+ + P+ + + E ++ Sbjct: 325 ANFALANYGSGALMGVPACDERDFEFANLYHIPIKVITQ------SPQNL--PHTKEEVL 376 Query: 384 VNSGPFDGTPSSEGIEKVINWLEEKGIGKRSVQYKLRDWLISRQRYWGAPIPIIYCEKCG 443 NSG + SS E++I + E++ +GKR + Y+L+DW +SRQRYWGAPIP+I+C CG Sbjct: 377 KNSGEWSDLSSSVAREQIIAYFEKENLGKRVINYRLQDWGVSRQRYWGAPIPMIHCNHCG 436 Query: 444 VVPVPEEDLPVRLPKDVEFLPTGQSPLSFHEGFKKTKCPVCGGEAQRETDTMDTFVDSSW 503 + VPE LPV LP+D+ G +PL H +K T+CP C A RETDTMDTF+ SSW Sbjct: 437 I--VPETQLPVTLPEDIVIDGEG-NPLEKHASWKFTQCPKCHKNALRETDTMDTFIQSSW 493 Query: 504 YFLRYVNP--HLEDKPFEPDDVNYWLPVDQYIGGVEHAVLHLLYSRFVTKVLHDLGYLNF 561 YFLRY P E++ F+ + + Y++PVD YIGG+EHA+LHLLY+RF TK L DLGYL+ Sbjct: 494 YFLRYTTPKNQRENQAFDQNYLKYFMPVDTYIGGIEHAILHLLYARFFTKALRDLGYLHL 553 Query: 562 DEPFTNLFTQGMIYKDGAKMSKSKGNVVSPDEMIEKYGADTLRMYILFMAPPEKDAEWSD 621 DEPF L TQGM+ K+GAKMSKSKGNVVSP E+++KYGAD R++ILF APP K+ EW+D Sbjct: 554 DEPFKQLITQGMVLKNGAKMSKSKGNVVSPKEILKKYGADAARLFILFAAPPAKELEWND 613 Query: 622 AGIEGVHRFVKRLWNTFYTVLPFVKEENTENLVLKNSTEKELRRKLHSIIKK---ITEDI 678 + +EG HRF+KRL++ + P + + + L N +K R+K++ +KK I Sbjct: 614 SALEGAHRFIKRLYDKANAINPTTSKPEFKEVSL-NEAQKLGRKKVYEALKKSHEIFNKA 672 Query: 679 EGGFKFNTAISGLMELVNHLSQYLNSVPQEEWNRKLLREIVEKLTLALSPFAPHLAEEFW 738 E + FNT I+ ME +N LS + N ++L E L L P PH A E Sbjct: 673 ESAYSFNTLIASCMEALNALS--------AQNNERILCEGYFVLLQILEPIIPHTAWEL- 723 Query: 739 HDLGNDSLVVQQSWP--SYDPKALEVEEVEIAIQINGKVRDKVVVPVDISEEDLKRIVLE 796 ++ L ++++ + D AL + + + + INGK R ++ V ++ S+E++ IVL Sbjct: 724 ----SERLFKRENFKPIAIDEDALMEDFMTLGLTINGKRRAELKVNINASKEEI--IVLA 777 Query: 797 RERVKEYVDGKPIRKFIYVKGRIVNIVV 824 ++ +++Y++ ++K IYV ++VN V+ Sbjct: 778 KKELEKYLENASVKKEIYVPNKLVNFVI 805sp|Q9ZDB1|SYL_RICPR LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS) >gi|3860978|emb|CAA14878| (AJ235271) LEUCYL-TRNA SYNTHETASE (leuS) [Rickettsia prowazekii] Length = 828 Score = 692 bits (1766), Expect = 0.0 Identities = 360/841 (42%), Positives = 501/841 (58%), Gaps = 69/841 (8%) Query: 23 FYTPQRSEKPKYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFG 82 F S KPKYY L M PYPSG +H+GHV+NY IGD++AR+ M+G+NVLHP G+DAFG Sbjct: 18 FQVSNESSKPKYYVLEMLPYPSGKIHIGHVRNYSIGDVIARFMTMQGFNVLHPMGWDAFG 77 Query: 83 LPAENAAIEKGIHPEEWTRKNIATIRQQVKKLGISYDWSREIATCDEEYYKWTQWIFLQL 142 LPAENAAI+ P++WT NI +++Q++ +G +YDW+REI +CD EYYK Q FL+L Sbjct: 78 LPAENAAIKNNSRPQDWTYSNIEYMKKQLQSMGFAYDWTREINSCDPEYYKHEQKFFLEL 137 Query: 143 YKNGLAYKKKAAVNWCPKCKTVLANEQVKDGKCERCGTSVTIRHLEQWFFKITDYAERLL 202 Y L Y+K++ VNW P TVLANEQV DG+ R G + R+L+QWF KITDYAE LL Sbjct: 138 YDRNLVYQKESLVNWDPVDNTVLANEQVVDGRGWRSGAIIEKRYLKQWFLKITDYAEELL 197 Query: 203 NDLDKLTGWPEHVKTMQRNWIGKSTGAEIDFPVE-GSDTKIRVFTTRPDTLWGVTFMXXX 261 N++ L WP V+ MQ WIGKSTG F V+ +T I VF+T+P+T++G +F+ Sbjct: 198 NEIQNLKDWPAAVRVMQEEWIGKSTGVNFHFKVKYHENTTIEVFSTKPETIFGASFIGIA 257 Query: 262 XXXXXXXXXXXXXXXXXXXXXXXRVKQQDRFRRTSV--EAEKEGFFLGRYAINPVTGER- 318 + + R+S +AEKEG F G Y I+P Sbjct: 258 FNHPIIEQLICKTPEIVNF-----ITKCSYITRSSEIDKAEKEGIFSGLYVIHPFDANIF 312 Query: 319 IPIYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPIKVVIKPADKDLDPEKMEEAYE 378 +P+ + N++LM+YGTGAI G PAHD+RD A K +PIK VI+ + Sbjct: 313 LPVIITNFVLMDYGTGAIFGCPAHDKRDHELAIKMNLPIKQVIETGNIQ----------- 361 Query: 379 GEGIMVNSGPFDGTPSSEGIEKVINWLEEKGIGKRSVQYKLRDWLISRQRYWGAPIPIIY 438 EGI++NS +G SSE +KVI E+ GIGKRSV Y+L+DW ISRQR+WG PIP+I+ Sbjct: 362 -EGILINSDWLNGLTSSEAKQKVIEKFEKLGIGKRSVNYRLKDWSISRQRFWGCPIPMIH 420 Query: 439 CEKCGVVPVPEEDLPVRLPKDVEFLPTGQSPLSFHEGFKKTKCPVCGGEAQRETDTMDTF 498 C+ CGVVPVP +DLPV LP DV F + +PL H +K CP C A RETDT DTF Sbjct: 421 CKTCGVVPVPYKDLPVTLPDDVSF-DSNYNPLEHHSSWKYVNCPKCDNSAIRETDTFDTF 479 Query: 499 VDSSWYFLRYVNPHLEDKPFEPDDVNYWLPVDQYIGGVEHAVLHLLYSRFVTKVLHDLGY 558 +SSWYF RY N + + + NYWLPVD+YIGG+EHAV+HLLY+RF TK++++ Y Sbjct: 480 FESSWYFTRYCNSNAVEMT-DKKACNYWLPVDKYIGGIEHAVMHLLYARFFTKLMNEHNY 538 Query: 559 LNFDEPFTNLFTQGMI----YKDG-------------------------------AKMSK 583 ++ EPF LFTQGM+ YKD KMSK Sbjct: 539 VSIREPFKGLFTQGMVLHATYKDENNNWLYPAEVVKKGNEFFHKENNTRVVQGRIEKMSK 598 Query: 584 SKGNVVSPDEMIEKYGADTLRMYILFMAPPEKDAEWSDAGIEGVHRFVKRLWNTFYTVLP 643 SK N++ + + E+Y AD +R+++L +PPEKD EWS +GIEG RF+ +L N F + Sbjct: 599 SKKNIIDLETIREQYSADAIRLFVLSDSPPEKDLEWSASGIEGCSRFINKLENMFEAIFS 658 Query: 644 FVKEENTENLVLKNSTEKELRRKLHSIIKKITEDIEGGFKFNTAISGLMELVNHLSQYLN 703 + +K+ K+L R +H IK + +DI+ F N AI+ + L N + Sbjct: 659 LKDD-------MKSEINKDLNRLIHLTIKHVADDIK-TFSLNRAIARMRTLTNAI---YY 707 Query: 704 SVPQEEWNRKLLREIVEKLTLALSPFAPHLAEEFWHDLGNDSLVVQQSWPSYDPKALEVE 763 + ++ + + ++ L L+PF PH+ EE W LGN + + + +D LE+ Sbjct: 708 EISKDRIDVRTIKYGFNVLVQLLNPFIPHITEEIWQKLGNKERLYKSVFAEFDESILELS 767 Query: 764 EVEIAIQINGKVRDKVVVPVDISEEDLKRIVLERERVKEYVDGKPIRKFIYVKGRIVNIV 823 +A+Q+NGK+RD VDISE+++K+I + +V++++ GK R I V +IVNI+ Sbjct: 768 TYIMAVQVNGKLRDTYEFDVDISEDEVKQITVNLPKVQKFLAGKEPRNIILVPRKIVNII 827 Query: 824 V 824 V Sbjct: 828 V 828gb|AAD36946.1|AF069441_6 (AF069441) putative leucyl tRNA synthetase [Arabidopsis thaliana] Length = 973 Score = 676 bits (1725), Expect = 0.0 Identities = 376/874 (43%), Positives = 500/874 (57%), Gaps = 86/874 (9%) Query: 23 FYTPQR--SEKPKYYALVMFPYPSGT-LHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYD 79 F TP + KPK+Y L MFPYPSG LHVGH Y DI+AR +RM+GYNVLHP G+D Sbjct: 104 FRTPDDVDTSKPKFYVLDMFPYPSGAGLHVGHPLGYTATDILARLRRMQGYNVLHPMGWD 163 Query: 80 AFGLPAENAAIEKGIHPEEWTRKNIATIRQQVKKLGISYDWSREIATCDEEYYKWTQWIF 139 AFGLPAE AIE G HP+ T KNI R Q+K LG SYDW RE++T + +YYKWTQWIF Sbjct: 164 AFGLPAEQYAIETGTHPKTTTLKNIDRFRLQLKSLGFSYDWDRELSTTEPDYYKWTQWIF 223 Query: 140 LQLYKNGLAYKKKAAVNWCPKCKTVLANEQVKDGKCERCGTSVTIRHLEQWFFKITDYAE 199 LQLYK GLAY+ + VNWCP TVLANE+V DG ER G V + + QW KIT YA+ Sbjct: 224 LQLYKKGLAYQAEVPVNWCPALGTVLANEEVVDGVSERGGHPVIRKPMRQWMLKITAYAD 283 Query: 200 RLLNDLDKLTGWPEHVKTMQRNWIGKSTGAEIDFPV---EG--SDTKIRVFTTRPDTLWG 254 RLL DLD+L WPE +K MQRNWIG+S GAE++F + EG +D +I V+TTRPDTL+G Sbjct: 284 RLLEDLDELE-WPESIKEMQRNWIGRSEGAELNFSILDGEGRETDKEITVYTTRPDTLFG 342 Query: 255 VTFMXXXXXXXXXXXXXXXXXXXXXXXXXXRVKQQDRFRRTSVEAEKEGFFLGRYAINPV 314 T+M ++ RT ++ +K G F G YA NP Sbjct: 343 ATYMVVAPEHQLLSYFVTAEQKQQVEEYKDFASRKSDLERTELQKDKTGVFTGCYAKNPA 402 Query: 315 TGERIPIYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPIKVVIKPADKDLDPEKME 374 G+ IPI+VA+Y+L YGTGAIM VPAHD RD FA KY IPIK V++ D K Sbjct: 403 NGDAIPIWVADYVLASYGTGAIMAVPAHDTRDNEFALKYNIPIKWVVRNEANSSDDAK-- 460 Query: 375 EAYEGEGIMVNSGPFD------GTPSSEGIEKVINWLEEKGIGKRSVQYKLRDWLISRQR 428 + Y G GI+ NS + S E KVI W E G GK+ V YKLRDWL +RQR Sbjct: 461 QVYPGLGIIENSSTLETGLDINQLSSKEAALKVIEWAERTGNGKKKVNYKLRDWLFARQR 520 Query: 429 YWGAPIPIIYCEKCG-VVPVPEEDLPVRLPKDVEFLP--TGQSPLSFHEGFKKTKCPVCG 485 YWG PIPI+ ++ G + + E +LP+ LP+ +F P TG+ PLS + T P G Sbjct: 521 YWGEPIPILILDESGETIAISESELPLTLPELNDFTPTGTGEPPLSKAVSWVNTVDPSTG 580 Query: 486 GEAQRETDTMDTFVDSSWYFLRYVNPHLEDKPFEPDDVNYWLPVDQYIGGVEHAVLHLLY 545 A+RET TM + S WY+LR+++P + + + YW PVD Y+GG EHAVLHLLY Sbjct: 581 KPAKRETSTMPQWAGSCWYYLRFMDPKNPEALVDKEKEKYWSPVDVYVGGAEHAVLHLLY 640 Query: 546 SRFVTKVLHDLGYLNFDEPFTNLFTQGMI--------YKD-------------------- 577 SRF KVL+D+G ++ EPF + QG+I +KD Sbjct: 641 SRFWHKVLYDIGVVSTKEPFKCVINQGIILGEVQYTAWKDQEGNYVSADTEERLNEHQQV 700 Query: 578 ---GAKMSKSKGNVV------------------------SPDEMIEKYGADTLRMYILFM 610 K+ KS + V +PD+++ +YGAD+LR+Y +FM Sbjct: 701 TIPEEKVIKSGDHFVLKEDPSIRLIPRVYKMSKSRGNVVNPDDVVLEYGADSLRLYEMFM 760 Query: 611 APPEKDAEWSDAGIEGVHRFVKRLWNTFYTVLPFVKEENTENLVLKNSTEKELRRKLHSI 670 P W+ +GIEGVHRF+ R W + LV + E R LH Sbjct: 761 GPFRDSKTWNTSGIEGVHRFLARTWRLVIGLPQSDGSFKDGTLVTDDEPTLEQLRTLHKC 820 Query: 671 IKKITEDIEGGFKFNTAISGLMELVNHLSQYLNSVPQEEWNRKLLREIVEKLTLALSPFA 730 I K+TE+IE +FNT ISG+ME VN +WN + R I+E L LSP+A Sbjct: 821 IAKVTEEIE-STRFNTGISGMMEFVN---------AAYKWNNQ-PRGIIEPFVLLLSPYA 869 Query: 731 PHLAEEFWHDLGNDSLVVQQSWPSYDPKALEVEEVEIAIQINGKVRDKVVVPVDISEEDL 790 PH+AEE W LG+ + + +S+P +P L+ + + +QINGK R + V SE+D Sbjct: 870 PHMAEELWSRLGHPNSLAYESFPKANPDYLKNTTIVLPVQINGKTRGTIEVEEGCSEDDA 929 Query: 791 KRIVLERERVKEYVDGKPIRKFIYVKGRIVNIVV 824 + + +++++Y+DG+ I+K IYV G+I+N+++ Sbjct: 930 FVLASQDDKLRKYLDGQSIKKRIYVPGKILNVIL 963sp|O66680|SYL_AQUAE LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS) >gi|2983033 (AE000685) leucyl-tRNA synthetase alpha subunit [Aquifex aeolicus] Length = 634 Score = 652 bits (1665), Expect = 0.0 Identities = 321/589 (54%), Positives = 400/589 (67%), Gaps = 35/589 (5%) Query: 24 YTPQRSEKPKYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGL 83 + Q + K+Y L MFPYPSG +H+GHV+NY IGD +ARY +MRG N+LHP G+DAFGL Sbjct: 24 FKAQEGKPNKFYVLEMFPYPSGRIHMGHVRNYTIGDAIARYLKMRGKNILHPMGWDAFGL 83 Query: 84 PAENAAIEKGIHPEEWTRKNIATIRQQVKKLGISYDWSREIATCDEEYYKWTQWIFLQLY 143 PAENAAI+ GIHP +WT +NI +++Q+K LG SYDW REIATCD EYYKW QWIFL++ Sbjct: 84 PAENAAIKHGIHPAKWTYENIDYMKKQLKILGFSYDWDREIATCDPEYYKWNQWIFLKML 143 Query: 144 KNGLAYKKKAAVNWCPKCKTVLANEQVKDGKCERCGTSVTIRHLEQWFFKITDYAERLLN 203 + G+AY+K A VNWCP +TVLANEQV +GKC RCGT + + + WF +IT YA+RLL Sbjct: 144 ERGIAYRKTAKVNWCPHDQTVLANEQVIEGKCWRCGTPIVQKEVPSWFLRITAYADRLLE 203 Query: 204 DLDKLTG-WPEHVKTMQRNWIGKSTGAEIDFPVEGSDTK--------------------- 241 DL KL G WPE V QRNWIG+S GA I F VE + + Sbjct: 204 DLKKLEGKWPERVIAQQRNWIGRSEGALIRFYVEIEEPEKFLNCVPEELKETLLKEKRIY 263 Query: 242 IRVFTTRPDTLWGVTFMXXXXXX------XXXXXXXXXXXXXXXXXXXXRVKQQDRFRRT 295 I VFTTRPDT++G TF+ ++K+ RT Sbjct: 264 IDVFTTRPDTVFGATFVVLAPEHPLVPVLACIGERLGNACYSDVENFVEKMKKMSTRERT 323 Query: 296 SVEAEKEGFFLGRYAINPVTGERIPIYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGI 355 +E +KEG FLG YA NP GE+IP++ ANY+L EYGTGAIM VPAHDQRD+ FAKKY + Sbjct: 324 -MEEDKEGVFLGVYATNPANGEKIPVWSANYVLYEYGTGAIMCVPAHDQRDWEFAKKYDL 382 Query: 356 PIKVVIKPADKDLDPEKMEEAYEGEGIMVNSGPFDGTPSSEGIEKVINWLEEKGIGKRSV 415 PIKVV+KP + D EK AYEG+G +VNS FDG S K+ WL+++G+G++ V Sbjct: 383 PIKVVVKP-EGAWDFEK--GAYEGKGTLVNSDGFDGLDSETAKRKITEWLQDRGLGEKKV 439 Query: 416 QYKLRDWLISRQRYWGAPIPIIYCEKCGVVPVPEEDLPVRLPKDVEFLPTGQ-SPLSFHE 474 Y+LRDW ISRQRYWG PIP++YCEKCG+VPVPE+ LPV+LP DV+F TGQ +PL E Sbjct: 440 SYRLRDWNISRQRYWGTPIPVVYCEKCGMVPVPEDQLPVKLPLDVKF--TGQGNPLETSE 497 Query: 475 GFKKTKCPVCGGEAQRETDTMDTFVDSSWYFLRYVNPHLEDKPFEPDDVNYWLPVDQYIG 534 F T CP CGG+A+RETDTMDTF DSSWYFLR+ +P + +PF + V+YW+PVD YIG Sbjct: 498 EFVNTTCPKCGGKARRETDTMDTFFDSSWYFLRFCDPKNDREPFSREKVDYWMPVDVYIG 557 Query: 535 GVEHAVLHLLYSRFVTKVLHDLGYLNFDEPFTNLFTQGMIYKDGAKMSK 583 G+EHAVLHLLY+RF K L DLG + DEPF L TQGM+ K + K Sbjct: 558 GIEHAVLHLLYARFFQKFLKDLGLVRDDEPFEKLITQGMVLKKWVSVKK 606sp|Q09828|SYLM_SCHPO PUTATIVE LEUCYL-TRNA SYNTHETASE, MITOCHONDRIAL PRECURSOR (LEUCINE--TRNA LIGASE) >gi|2130436|pir||S62486 hypothetical protein SPAC4G8.09 - fission yeast (Schizosaccharomyces pombe) >gi|1022354|emb|CAA91210.1| (Z56276) putative leucyl trna synthetase [Schizosaccharomyces pombe] Length = 874 Score = 606 bits (1545), Expect = e-172 Identities = 339/843 (40%), Positives = 483/843 (57%), Gaps = 81/843 (9%) Query: 33 KYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAENAAIEK 92 K Y L MFPYPSG LH+GHV+ Y I DI++RY RM+GY V+HP G+DAFGLPAENAAIE Sbjct: 59 KKYILSMFPYPSGLLHIGHVRVYTISDILSRYYRMKGYKVIHPMGWDAFGLPAENAAIEN 118 Query: 93 GIHPEEWTRKNIATIRQQVKKLGISYDWSREIATCDEEYYKWTQWIFLQLYKNGLAYKKK 152 GI WT +NI +++Q + I +DW REI+TC+ +YYKW+Q++FLQ++ GLAY+ + Sbjct: 119 GISASSWTYENIKKMKEQTYHMNIYFDWDREISTCNPDYYKWSQYLFLQMFHKGLAYQAE 178 Query: 153 AAVNWCPKCKTVLANEQVKD-GKCERCGTSVTIRHLEQWFFKITDYAERLLNDLDKLTGW 211 A VNW P TVLANEQV G+ R G V ++L QWF KI+DY+++LL+DL+ L W Sbjct: 179 ATVNWDPVDCTVLANEQVDSHGRSWRSGAIVEKKNLRQWFLKISDYSDQLLDDLETLPKW 238 Query: 212 PEHVKTMQRNWIGKSTGAEIDFPVEGSDTKIRVFTTRPDTLWGVTFMXXXXXXXXXXXXX 271 P+ VK MQRNWIG++TG EI FP+ + VFTT+P+T+ V+F+ Sbjct: 239 PDKVKKMQRNWIGRTTGFEISFPLLNDKETLTVFTTKPETIIDVSFIALSKNHKLVLLES 298 Query: 272 XXXXXXXXXXXXXRVKQQDRFRRTSVEAEKEGFFLGRYAINPVTGERIPIYVANYILMEY 331 + R S+ +G+ L +A NPVTG+ +PI+ A Y+L Y Sbjct: 299 QKDPSLA-----------EHLRNESLL--DKGYQLPCFAKNPVTGKALPIFYAPYVLDCY 345 Query: 332 GTGAIMGVPAHDQRDFSFAKKYGIPIKVVIKPADKDLDPEKMEEAY---EGEGIMVNSGP 388 GTGA+MG P HD+RDF FAK+ I E +Y EG+ ++ + Sbjct: 346 GTGAVMGAPIHDRRDFEFAKRNNIIFS-----------KESCIGSYFTNEGKELLNHHDS 394 Query: 389 FDGTPSSEGI--EKVINWLEEKGIGKRSVQYKLRDWLISRQRYWGAPIPIIYCEKCGVVP 446 + + + +K++++LEEK + KR Y+L+DWLISRQR+WG PIP+++CE CG VP Sbjct: 395 SNLMDIKQKMLQQKIVSYLEEKKLAKRVKNYRLKDWLISRQRFWGTPIPMVHCETCGAVP 454 Query: 447 VPEEDLPVRLPKDVEFLPTGQSPLSFHEGFKKTKCPVCGGEAQRETDTMDTFVDSSWYFL 506 VPE +LPV+LP + G SPLS E + KT CP C G A RETDTMDTFVDSSWY+ Sbjct: 455 VPESELPVKLPDLDKIYEKGTSPLSNLETWMKTTCPKCHGPATRETDTMDTFVDSSWYYF 514 Query: 507 RYVNPHLEDKPFEPDDVNYWLPVDQYIGGVEHAVLHLLYSRFVTKVLHDLGYLNFD---- 562 R+++ + P + +PVD YIGGVEH++LHLLYSRF +K + D+G N D Sbjct: 515 RFLDSKNSELPVGLASASSLMPVDIYIGGVEHSILHLLYSRFFSKFMKDIGLWNGDKYLN 574 Query: 563 EPFTNLFTQGMIY-------------------KDG-----------------AKMSKSKG 586 EPFT L TQGM++ K G KMSKSK Sbjct: 575 EPFTQLITQGMVHGLTYTTMSDERILNPKEVQKIGDEYFLISNPKEKVQLSYQKMSKSKH 634 Query: 587 NVVSPDEMIEKYGADTLRMYILFMAPPEKDAEWSDAGIEGVHRFVKRLWNTFYTVLPFVK 646 N V P I+KYG+D +R YI+F AP E W++ I G R++ ++WN + +L K Sbjct: 635 NGVDPIRTIQKYGSDIIRAYIIFSAPVEGVLLWNENAIMGTKRWLTKIWNCVHQLLEREK 694 Query: 647 E-----ENTENLVLKNSTEKELRRKLHSIIKKITEDIEGGFKFNTAISGLMELVNHLSQY 701 + T+ ++ + ++L + + I + + E F N IS M+L N+++ Sbjct: 695 KMSDAMRQTKLTIVDDHNSRKLESQYNEFISQCSAHYENVFSLNLVISDAMKLTNNIADA 754 Query: 702 LNSVPQEEWNRKLLREIVEKLTLALSPFAPHLAEEFWHDLGNDSLVVQQSWPSYDPKALE 761 L + + N ++ +E L ++P P + E W LG++S V +WP K Sbjct: 755 LKN---NKVNIGTIKASLEVLVKCIAPIIPCFSSECWLLLGHNS-SVYSNWPISKNKKEN 810 Query: 762 VEE-VEIAIQINGKVRDKVVVPVDISEEDLKRIVLERERVKEYVDGKPIRKFIYVKGRIV 820 +EE V I +QINGKVR K+ +P E ++ VLE K ++ K + K +VK +I+ Sbjct: 811 MEEPVTIPVQINGKVRFKIEMPKLNDENEILNFVLETNDGKRWLSNKKVLK-SFVKQKII 869 Query: 821 NIV 823 ++V Sbjct: 870 SLV 872gb|AAC67801.1| (AE001294) Leucyl tRNA Synthetase [Chlamydia trachomatis] Length = 819 Score = 588 bits (1500), Expect = e-167 Identities = 341/845 (40%), Positives = 471/845 (55%), Gaps = 90/845 (10%) Query: 23 FYTPQRSEKPKYYALVMFPYPSGT-LHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAF 81 F + K KYY L MFPYPSG LHVGH+ Y DIVARYKR +G++VLHP G+D+F Sbjct: 22 FKAEEDETKTKYYVLDMFPYPSGAGLHVGHLIGYTATDIVARYKRAQGFSVLHPMGWDSF 81 Query: 82 GLPAENAAIEKGIHPEEWTRKNIATIRQQVKKLGISYDWSREIATCDEEYYKWTQWIFLQ 141 GLPAE AI G HP E T KNIA ++Q+ +G SYD SRE AT D EYYKWTQ +FL Sbjct: 82 GLPAEQYAIRTGTHPRETTEKNIANFKKQLTAMGFSYDESREFATSDPEYYKWTQKLFLI 141 Query: 142 LYKNGLAYKKKAAVNWCPKCKTVLANEQVKDGKCERCGTSVTIRHLEQWFFKITDYAERL 201 LY+ GLAY AVN+CP+ TVL+NE++++G G V R L QW +IT +A++L Sbjct: 142 LYEKGLAYMADMAVNYCPELGTVLSNEEIENGFSVDGGYPVERRMLRQWVLRITAFADQL 201 Query: 202 LNDLDKLTGWPEHVKTMQRNWIGKSTGAEIDFPVEGSDTKIRVFTTRPDTLWGVTFMXXX 261 L LD+L WPE VK +Q+NWIGKS+GA ++F E I VFTTRPDTL GV+F+ Sbjct: 202 LEGLDEL-DWPESVKQLQKNWIGKSSGASVNFATEHG--VIEVFTTRPDTLIGVSFLALA 258 Query: 262 XXXXXXXXXXXXXXXXXXXXXXXRVKQQDRFRRTSVEAEKEGFFLGRYAINPVTGERIPI 321 + + R S K G F G YA +PVT + IPI Sbjct: 259 PEHPLVDLLTSDEQKAVVAQYIKETQSKSERDRISEMKTKSGVFTGSYAKHPVTHKLIPI 318 Query: 322 YVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPIKVVIKPADKDLDPEKMEEAYEGEG 381 ++A+Y+L+ +G+GA+MGVPAHD+RD FA+++ +P+ V+ EG Sbjct: 319 WIADYVLIGFGSGAVMGVPAHDERDLLFAEQFNLPVVSVLNK----------------EG 362 Query: 382 IMVNS----GPFDGTPSSEGIEKVINWLEEKGIGKRSVQYKLRDWLISRQRYWGAPIPII 437 + +NS DG E + VIN+LEE +G + YKLRDWL SRQRYWG PIPII Sbjct: 363 VCINSCCEGFHLDGLSGEEAKQYVINFLEENHLGAAKIAYKLRDWLFSRQRYWGEPIPII 422 Query: 438 YCEKCGVVPVPEEDLPVRLPKDVEFLP--TGQSPLSFHEGFKKTKCPVCGGEAQRETDTM 495 + E P+ + +LP+ P+ ++ P GQ PL+ + + +RET TM Sbjct: 423 HFEDGSCRPLRDYELPLLPPEIQDYRPEGVGQGPLAKVREWVQVFDTETQRAGKRETHTM 482 Query: 496 DTFVDSSWYFLRYVNPHLEDKPFEPDDVNYWLPVDQYIGGVEHAVLHLLYSRFVTKVLHD 555 + S WY+LR+ + H P+ + YW+PVD YIGG EHAVLHLLY+RF +V ++ Sbjct: 483 PQWAGSCWYYLRFCDAHNSAAPWAKEKEQYWMPVDLYIGGAEHAVLHLLYARFWHQVFYE 542 Query: 556 LGYLNFDEPFTNLFTQGM-------------IYKDGA--------------------KMS 582 G ++ EPF L QG+ IY + A KMS Sbjct: 543 AGIVSTPEPFKKLVNQGLVLATSYRIPGKGYIYPEIAKEENGKWVAPSGEELDVRQEKMS 602 Query: 583 KSKGNVVSPDEMIEKYGADTLRMYILFMAPPEKDAEWSDAGIEGVHRFVKRLWNTFYTVL 642 KSK N V P +I+++GAD +RMY +F P +K+ WS+ G+ G RF+ N FY ++ Sbjct: 603 KSKLNGVDPQILIDEFGADAVRMYAMFSGPLDKNKLWSNQGVAGCRRFL----NRFYEMV 658 Query: 643 PF--VKEENT-ENLVLKNSTEKELRRKLHSIIKKITEDIEGGFKFNTAISGLMELVNHLS 699 VKE+N E L L H +++++T+ IE NT S ME +N Sbjct: 659 SSDRVKEDNNFEGLSL-----------AHKLVQRVTDAIE-KLSLNTIPSSFMEFINDFV 706 Query: 700 QYLNSVPQEEWNRKLLREIVEKLTLALSPFAPHLAEEFWHDLGNDSLVVQQSWPSYDPKA 759 + L P + VE AL+P APH++EE W LGN V + WPS P+ Sbjct: 707 K-LAVYP---------KSAVEMAVRALAPIAPHISEELWVLLGNSPGVQKSGWPSVLPEY 756 Query: 760 LEVEEVEIAIQINGKVRDKVVVPVDISEEDLKRIVLERERVKEYVDGKPIRKFIYVKGRI 819 LE + V I +Q+NGK+R ++ + D S+E++ + L RE +Y++G ++K I+V R+ Sbjct: 757 LEGQTVTIVVQVNGKLRARLDIMKDASKEEV--LALARESASKYLEGCEVKKAIFVPARL 814 Query: 820 VNIVV 824 VN VV Sbjct: 815 VNFVV 819gb|AAD18306| (AE001602) Leucyl tRNA Synthetase [Chlamydia pneumoniae] Length = 820 Score = 571 bits (1455), Expect = e-161 Identities = 335/850 (39%), Positives = 465/850 (54%), Gaps = 99/850 (11%) Query: 23 FYTPQRSEKPKYYALVMFPYPSGT-LHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAF 81 F + +K KYY L MFPYPSG LHVGH+ Y DIVARYKR RG++VLHP G+D+F Sbjct: 22 FQANEDEDKVKYYVLDMFPYPSGAGLHVGHLIGYTATDIVARYKRARGFSVLHPMGWDSF 81 Query: 82 GLPAENAAIEKGIHPEEWTRKNIATIRQQVKKLGISYDWSREIATCDEEYYKWTQWIFLQ 141 GLPAE AI G HP+ T+KNIA ++Q+ +G SYD RE AT D +YY WTQ +FL Sbjct: 82 GLPAEQYAIRTGTHPKVTTQKNIANFKKQLSAMGFSYDEGREFATSDPDYYHWTQKLFLF 141 Query: 142 LYKNGLAYKKKAAVNWCPKCKTVLANEQVKDGKCERCGTSVTIRHLEQWFFKITDYAERL 201 LY GLAY AVN+CP+ TVL+NE+V++G G V + L QW KIT YA++L Sbjct: 142 LYDQGLAYMADMAVNYCPELGTVLSNEEVENGFSIEGGYPVERKMLRQWILKITAYADKL 201 Query: 202 LNDLDKLTGWPEHVKTMQRNWIGKSTGAEIDFPV--EGSDTKIRVFTTRPDTLWGVTFMX 259 L LD L WPE+VK +Q+NWIGKS GA + F + EGS + FTTR DTL GV+F+ Sbjct: 202 LEGLDAL-DWPENVKQLQKNWIGKSEGALVTFHLTQEGS---LEAFTTRLDTLLGVSFLV 257 Query: 260 XX-XXXXXXXXXXXXXXXXXXXXXXXRVKQQDRFRRTSVEAEKEGFFLGRYAINPVTGER 318 +++ +R R +SV+ K G F G YA +P+TG Sbjct: 258 IAPEHPDLDSIVSEEQRDEVTAYVQESLRKSERDRISSVKT-KTGVFTGNYAKHPITGNL 316 Query: 319 IPIYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPIKVVIKPADKDLDPEKMEEAYE 378 +P+++++Y+++ YGTG +MGVPAHD+RD FA+ + +PI VI + Sbjct: 317 LPVWISDYVVLGYGTGVVMGVPAHDERDREFAEMFSLPIHEVI----------------D 360 Query: 379 GEGIMVNSGPFD----GTPSSEGIEKVINWLEEKGIGKRSVQYKLRDWLISRQRYWGAPI 434 G+ ++S D G E + VIN+LE + +G+ Y+LRDWL SRQRYWG PI Sbjct: 361 DNGVCIHSNYNDFCLNGLSGQEAKDYVINYLEMRSLGRAKTMYRLRDWLFSRQRYWGEPI 420 Query: 435 PIIYCEKCGVVPVPEEDLPVRLPKDVEFLPT--GQSPLS-----FHEGFKKTKCPVCGGE 487 PII+ E P+ +++LP+ P ++ P GQ PL+ H +KT P C Sbjct: 421 PIIHFEDGTHRPLEDDELPLLPPNIDDYRPEGFGQGPLAKAQDWVHIYDEKTGRPGC--- 477 Query: 488 AQRETDTMDTFVDSSWYFLRYVNPHLEDKPFEPDDVNYWLPVDQYIGGVEHAVLHLLYSR 547 RET TM + S WY+LR+ + H P+ + +YW+PVD YIGG EHAVLHLLYSR Sbjct: 478 --RETYTMPQWAGSCWYYLRFCDAHNSQLPWSKEKESYWMPVDLYIGGAEHAVLHLLYSR 535 Query: 548 FVTKVLHDLGYLNFDEPFTNLFTQGMIYKDG----------------------------- 578 F +V +D G ++ EPF L QG++ Sbjct: 536 FWHRVFYDAGLVSTPEPFKKLINQGLVLASSYRIPGKGYVSIEDVREENGTWISTCGEIV 595 Query: 579 ----AKMSKSKGNVVSPDEMIEKYGADTLRMYILFMAPPEKDAEWSDAGIEGVHRFVKRL 634 KMSKSK N V P +IE+YGAD LRMY +F P +K+ WS+ G+ G RF+ R Sbjct: 596 EVRQEKMSKSKLNGVDPQVLIEEYGADALRMYAMFSGPLDKNKTWSNEGVGGCRRFLNRF 655 Query: 635 WNTFYTVLPFVKEENTENLVLKNSTEKELRRKLHSIIKKITEDIEGGFKFNTAISGLMEL 694 ++ T E+ + LVL H ++ +ITE IE NT S ME Sbjct: 656 YD-LVTSSEVQDIEDRDGLVL-----------AHKLVFRITEHIE-KMSLNTIPSSFMEF 702 Query: 695 VNHLSQYLNSVPQEEWNRKLLREIVEKLTLALSPFAPHLAEEFWHDLGNDSLVVQQSWPS 754 +N S+ ++++ L V L P APH++EE W LGN + Q +WP Sbjct: 703 LNDFSKL------PVYSKRALSMAVR----VLEPIAPHISEELWVILGNPPGIDQAAWPQ 752 Query: 755 YDPKALEVEEVEIAIQINGKVRDKVVVPVDISEEDLKRIVLERERVKEYVDGKPIRKFIY 814 D L + V +Q+NGK+R ++ V + +E++ + L R V +Y++ IRK IY Sbjct: 753 IDESYLVAQTVTFVVQVNGKLRGRLEVAKEAPKEEV--LSLSRSVVAKYLENAQIRKEIY 810 Query: 815 VKGRIVNIVV 824 V ++VN V+ Sbjct: 811 VPNKLVNFVL 820sp|P13503|SYLM_SACDO LEUCYL-TRNA SYNTHETASE, MITOCHONDRIAL PRECURSOR (LEUCINE--TRNA LIGASE) (LEURS) >gi|68519|pir||SYBYMX leucine--tRNA ligase (EC 6.1.1.4) precursor, mitochondrial - yeast (Saccharomyces sp.) >gi|4842|emb|CAA31343| (X12864) leucyl tRNA synthetase (AA 1-894) [Saccharomyces douglasii] Length = 894 Score = 564 bits (1438), Expect = e-159 Identities = 324/847 (38%), Positives = 467/847 (54%), Gaps = 82/847 (9%) Query: 35 YALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAENAAIEKGI 94 Y L FPYPSG LH+GH++ YVI D + R+ + RGYNV+HP G+DAFGLPAENAAIE+GI Sbjct: 50 YILCQFPYPSGVLHIGHLRVYVISDSLNRFYKQRGYNVIHPMGWDAFGLPAENAAIERGI 109 Query: 95 HPEEWTRKNIATIRQQVKKLGISYDWSREIATCDEEYYKWTQWIFLQLYKNGLAYKKKAA 154 +P WTR NIA ++QQ++ + ++DW RE+ TCD EYYK+TQWIFL+L++NGLAY+K+A Sbjct: 110 NPAIWTRDNIAKMKQQMESMLANFDWDREVTTCDPEYYKFTQWIFLKLFENGLAYRKEAE 169 Query: 155 VNWCPKCKTVLANEQV-KDGKCERCGTSVTIRHLEQWFFKITDYAERLLNDLDKLTGWPE 213 +NW P KTVLANEQV G+ R G V + L+QWF IT +A +L L++L WP Sbjct: 170 INWDPVDKTVLANEQVDAQGRSWRSGAIVEKKQLKQWFLGITKFAPKLRKHLNQLKDWPS 229 Query: 214 HVKTMQRNWIGKSTGAEIDFPVEGSD-TKIRVFTTRPDTLWGVTFMXXXXXXXXXXXXXX 272 +VK MQ+NWIG+S GAE+ F V S + VFTTRP+TL+ V ++ Sbjct: 230 NVKQMQKNWIGESIGAELVFKVADSKFENLIVFTTRPETLFAVQYVALALDHPIVQKYSE 289 Query: 273 XXXXXXXXXXXXRVKQQDRFRRTSVEAEKEGFFLGRY-AINPVTGERIPIYVANYILMEY 331 +++ D+ + KEGF L A+NP+T E +PI+ A Y++ Y Sbjct: 290 VIPDLKEF-----LQKSDQLPSDT----KEGFRLPDIKAVNPLTKEELPIFAAPYVISSY 340 Query: 332 GT--GAIMGVPAHDQRDFSFAKKY--GIPIKVVIKPADKDLDPEKMEEAYE--------- 378 GT A+MG P HD RDF F ++ G IK I P D +E + Sbjct: 341 GTAPSAVMGCPGHDSRDFEFWQQNCPGEHIKTCIAPFFDDASKTSEKERQKIIDTVPFTS 400 Query: 379 GEGIMV-NSGPFDGTPSSEGIEKVINWLEEKGIGKRSVQYKLRDWLISRQRYWGAPIPII 437 +GI+ SG + G ++ + ++ L KG+ K ++Y++RDWLISRQRYWG PIPII Sbjct: 401 ADGILTKESGEYSGVFTAVARKSIMGKLHSKGLSKNIIRYRIRDWLISRQRYWGTPIPII 460 Query: 438 YCEKCGVVPVPEEDLPVRLPKDVEFLPTGQSPLSFHEGFKKTKCPVCGGEAQRETDTMDT 497 +C+ CG VPVPE DLPV+LP +++ L T +PLS + F CP CG A+RETDTMDT Sbjct: 461 HCDNCGPVPVPESDLPVKLP-ELKGLDTKGNPLSTIDEFVNVACPSCGSPAKRETDTMDT 519 Query: 498 FVDSSWYFLRYVNPHLEDKPFEPDDVNYWLPVDQYIGGVEHAVLHLLYSRFVTKVLHDLG 557 F+DSSWY+ R+++P KPF+ + + +PVD YIGGVEHA+LHLLYSRF+ K L + Sbjct: 520 FIDSSWYYFRFLDPKNTSKPFDREIASEHMPVDIYIGGVEHAILHLLYSRFIAKFLGSIN 579 Query: 558 Y----LNFDEPFTNLFTQGMIY------------------------KDG----------- 578 EPF L TQGM+ DG Sbjct: 580 AWDDPTGIFEPFRKLVTQGMVQGKTYVDPDSGKFLTPDELTFVKDPSDGNTTIIKSNGKI 639 Query: 579 -----AKMSKSKGNVVSPDEMIEKYGADTLRMYILFMAPPEKDAEWSDAGIEGVHRFVKR 633 KMSKSK N P+E I ++GAD R +ILF +P W ++ I G+ R++++ Sbjct: 640 PMVSYEKMSKSKHNGADPNECILRHGADATRAHILFQSPIADALNWDESKIVGIERWLQK 699 Query: 634 LWNTFYTVLPFVK----EENTENLVLKNSTEKELRRKLHSIIKKITEDIEGGFKFNTAIS 689 + +L K ++ + N E + +K ITE E NT IS Sbjct: 700 VLCLTKNILGLEKNLAISKDYKTPTDLNDAEVKFHNDFQRFLKSITESFEVHLSLNTVIS 759 Query: 690 GLMELVNHLSQYLNSVPQEEWNRKLLREIVEKLTLALSPFAPHLAEEFWHDLGNDSLVVQ 749 M+L N L +++ + E ++++ + ++KL + P P ++EE + + Q Sbjct: 760 DYMKLTNLLE---SALKKSEVRKEMMVQNLQKLVTIIYPAVPSISEEAAELISSQMEWNQ 816 Query: 750 QSWPSYDPKALEVEEVEIAIQINGKVRDKVVVPVDISEEDLKRIV---LERERVKEYVDG 806 WP + + E + + I +NG+V+ D + ++ L+ + Y+ Sbjct: 817 YRWPEVE-RTTESKFKKFQIVVNGRVKFMYTADKDFLKSGRDAVIETLLKLPEGRMYLMN 875 Query: 807 KPIRKFI 813 K I+KF+ Sbjct: 876 KKIKKFV 882sp|P15181|SYLM_NEUCR LEUCYL-TRNA SYNTHETASE, MITOCHONDRIAL PRECURSOR (LEUCINE--TRNA LIGASE) (LEURS) >gi|68520|pir||SYNCLM leucine--tRNA ligase (EC 6.1.1.4) precursor, mitochondrial - Neurospora crassa >gi|168830 (M30472) leucyl-tRNA synthetase [Neurospora crassa] Length = 994 Score = 554 bits (1412), Expect = e-156 Identities = 341/928 (36%), Positives = 487/928 (51%), Gaps = 144/928 (15%) Query: 28 RSEKPKYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAEN 87 + ++ Y L MFPYPSG LH+GH++ Y I D++AR++ ++G+ VL P G+DAFGLPAEN Sbjct: 80 KEDEKNKYVLPMFPYPSGHLHLGHLRVYTIADVIARFQTLQGHKVLLPMGWDAFGLPAEN 139 Query: 88 AAIEKGIHPEEWTRKNIATIRQQVKKLGISYDWSREIATCDEEYYKWTQWIFLQLYKNGL 147 AAIE+GI+P WT+ NIA +++Q+ + S+DW+ E+ATCD ++YK TQ IFL L++ GL Sbjct: 140 AAIERGINPATWTKANIAKMKEQLGHMNGSWDWNCELATCDPDFYKHTQKIFLALHEKGL 199 Query: 148 AYKKKAAVNWCPKCKTVLANEQVKDGKCE-RCGTSVTIRHLEQWFFKITDYAERLLNDLD 206 AY+ +A VN+ P KTVLANEQV C R G V R L+QWF KI+++ E LL DL+ Sbjct: 200 AYQAEAEVNYDPVDKTVLANEQVDANGCSWRSGARVEKRKLKQWFLKISEFRESLLKDLE 259 Query: 207 KLT---GWPEHVKTMQRNWIGKSTGAEIDFPV----EGSDTKIRVFTTRPDTLWGVTFMX 259 L WPE V MQ+NW+GKS GA + FPV +G+ + I VFT+RPDTL+GV ++ Sbjct: 260 TLAKNEAWPERVLAMQKNWLGKSKGATVKFPVLAFGQGTPSAIEVFTSRPDTLFGVQYIA 319 Query: 260 XXXXXXXXXXXXXXXXXXXXXXXXXRVKQQDRFRRTSVEAEKEGFFLGRY-AINPV---- 314 D K G+ L A+NP+ Sbjct: 320 LAATHPSVQQLAKSDPELQAFLSTLPGLSPD---------SKVGYLLPHIRAVNPLAYHE 370 Query: 315 -----TGERIPIYVANYILMEYGTGAIMGVPAHDQRDFSFAKK--YGIPIKVVIKPADKD 367 T +PIYVA Y+L +YG GA+MGVP HD RD +F K+ Y P++ V+ ++ + Sbjct: 371 ETPEDTKVSLPIYVAPYVLGDYGEGAVMGVPGHDLRDHAFWKEHHYDAPVRFVLAASEDE 430 Query: 368 LDPEKMEEAYEGEGIM-VNSGPFDGTPSSEGIEKVINWLEEKGIGKRSVQYKLRDWLISR 426 E + G+M NSG F G S E E ++ LE G+ K + +++LRDWLISR Sbjct: 431 STTAMPNEPFTEHGVMNANSGIFKGKSSKEAGEMLVKLLEPAGLAKETEKWRLRDWLISR 490 Query: 427 QRYWGAPIPIIYCEKCGVVPVPEEDLPVRLPKDVEFLP---TGQSPLSFHEGFKKTKCPV 483 QRYWG PIPI++C CG VPVP+E LPV LP+ E TG +PL + T CP Sbjct: 491 QRYWGTPIPIVHCGSCGTVPVPDEQLPVELPEVDEHWAGKKTG-NPLESQTDWINTSCPK 549 Query: 484 CGGEAQRETDTMDTFVDSSWYFLRYVNPHLEDKPFEPDDVNYWLPVDQYIGGVEHAVLHL 543 CGGEA+R+TDTMDTFVDSSWY++R+++ H ++ PF P+ PVD YIGGVEHA+LHL Sbjct: 550 CGGEAKRDTDTMDTFVDSSWYYMRFIDAHNKEAPFSPEKAKVLTPVDLYIGGVEHAILHL 609 Query: 544 LYSRFVTKVLHDLGYLNFD---------------EPFTNLFTQGMI----YKDGA----- 579 LYSRF+ K L + + EPF L TQGM+ Y D A Sbjct: 610 LYSRFIYKFLMTSSFAGKEAESAEAAESASSEVYEPFKRLITQGMVHGKTYTDPATGRFL 669 Query: 580 ---------------------------KMSKSKGNVVSPDEMIEKYGADTLRMYILFMAP 612 KMSKSK N V P I +YGAD R +ILF AP Sbjct: 670 KPDEVDLSDPHQPKVVATGALANVSYEKMSKSKHNGVDPTTFIAQYGADATRAHILFQAP 729 Query: 613 PEKDAEWSDAGIEGVHRFVKRLW---------------NTFYTVLPFVKEENTENLVLKN 657 + +W ++ I GV R++ R+ ++ TV F +++ + + + Sbjct: 730 VSEILDWDESKITGVTRWLSRVHDLVQKIACSSTSETPSSASTVKAFFEQQQQQPESVAD 789 Query: 658 STEKE----LRRKLHSIIKKITEDIEGGFKFNTAISGLMELVNHLSQYLNSVPQEEWNRK 713 + + + R++ I +T + NT IS LM L N ++ N + + Sbjct: 790 PAKLDASITIWREVQRTISSVTASYNKVYTLNTVISDLMSLTNVIASPSN---YDAADPL 846 Query: 714 LLREIVEKLTLALSPFAPHLAEEFWHDL--------------------GNDSLVVQQSWP 753 + RE V L ++P AP AEE WH L D + P Sbjct: 847 IRREAVSALIRMMAPVAPAFAEECWHVLFPESSSSSLFSGSGSGSGSGSGDEQAARFPVP 906 Query: 754 SYDPKALEVEEVEIAIQINGKVRDKVVV---PVDI----SEEDLKRI----VLERERVKE 802 L+ + A+Q+NGK + V + P + +EE L+ VL+ E + Sbjct: 907 DGTEGLLKSRKQTCAVQLNGKTKFAVEIGTPPAGLLEKSAEEKLREFIVGEVLKTEEGRA 966 Query: 803 YVDGKPI-----RKFIYVK-GRIVNIVV 824 ++G+ + +K I V+ G+++N+V+ Sbjct: 967 KLEGRGVDVSKAKKVIVVRGGKLLNVVM 994sp|Q50192|SYL_MYCLE LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS) >gi|2370271|emb|CAA75192| (Y14967) leucyl-tRNA synthetase [Mycobacterium leprae] Length = 972 Score = 552 bits (1408), Expect = e-156 Identities = 338/928 (36%), Positives = 468/928 (50%), Gaps = 161/928 (17%) Query: 33 KYYALVMFPYPSGT-LHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAENAAIE 91 K + MFPYPSG LHVGH Y+ D+ ARY RM G+NVLH G+DAFGLPAE A++ Sbjct: 70 KLFVQDMFPYPSGDGLHVGHPLGYIATDVYARYFRMTGHNVLHAMGFDAFGLPAEQYAMQ 129 Query: 92 KGIHPEEWTRKNIATIRQQVKKLGISYDWSREIATCDEEYYKWTQWIFLQLYKNG----- 146 G HP T N+ R Q+ +LG+ +D R +T D E+YKWTQWIFLQ+Y Sbjct: 130 TGTHPRILTEANVVNFRHQLGRLGLGHDSRRTFSTTDVEFYKWTQWIFLQIYNAWFDVAA 189 Query: 147 ------------------------------------------LAYKKKAAVNWCPKCKTV 164 L Y+ + VNWCP TV Sbjct: 190 NKARPIAELIAEFDSGERRLVDGRDWATLSAGERADVIDNCRLVYRADSMVNWCPGLGTV 249 Query: 165 LANEQVK-DGKCERCGTSVTIRHLEQWFFKITDYAERLLNDLDKLTGWPEHVKTMQRNWI 223 LANE+V DG+ +R V + L QW +IT YA+RLL+DLD L WPE VKTMQRNWI Sbjct: 250 LANEEVTADGRSDRGNFPVFRKRLRQWMMRITAYADRLLDDLD-LLDWPEQVKTMQRNWI 308 Query: 224 GKSTGAEIDFPV-------EGSDTKIRVFTTRPDTLWGVTFMXXXXXXXXX--------- 267 G+S+GA + F ++ + VFTTRPDT++GVT++ Sbjct: 309 GRSSGATVLFSAILSRSDAATTEVDVEVFTTRPDTMFGVTYLVLAPEHNLVDELVATVWP 368 Query: 268 -------XXXXXXXXXXXXXXXXXRVKQQDRFRRTSVEAEKEGFFLGRYAINPVTGERIP 320 V + D R+ S EK G FLGRYA NP TG+ +P Sbjct: 369 DRTDPRWTYGAATPGAAVAAYRRAIVAKSDLDRQES--KEKTGVFLGRYATNPATGKPVP 426 Query: 321 IYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPIKVVIKPADKDLDPEKMEEAYEGE 380 I+VA+Y+L+ YGTGA+M VP HD RD+ FA K+ +PI VI +D E AY G+ Sbjct: 427 IFVADYVLVGYGTGAVMAVPGHDPRDWDFAHKFHLPIVEVIAGSDIS------EAAYVGD 480 Query: 381 GIMVNSGPFDGTPSSEGIEKVINWLEEKGIGKRSVQYKLRDWLISRQRYWGAPIPIIYCE 440 G++VNSG DG + E + LE +G G +++KLRDWL +RQRYWG P PIIY Sbjct: 481 GVLVNSGYLDGMDVATAQEAITARLESEGRGHARIEFKLRDWLFARQRYWGEPFPIIYDS 540 Query: 441 KCGVVPVPEEDLPVRLPKDVEFLPT----------GQSPLSFHEGFKKTKCPVCGG--EA 488 + E LPV LP + P PL+ + + + G Sbjct: 541 DGRPHALDEAALPVELPDVPYYSPVLFDPDDADSEPSPPLAKATEWVHVELDLGDGLKPY 600 Query: 489 QRETDTMDTFVDSSWYFLRYVNPHLEDKPFEPDDVNYWL-------------PVDQYIGG 535 R+T+ M + SSWY LRY +PH ++ ++ YW+ VD Y+GG Sbjct: 601 SRDTNVMPQWAGSSWYELRYTDPHNSERLCAKENEAYWMGPRPTEHGIDDPGGVDLYVGG 660 Query: 536 VEHAVLHLLYSRFVTKVLHDLGYLNFDEPFTNLFTQGMI--------------------- 574 EHAVLHLLY+RF KVL+DLG+++ EP+ L QG I Sbjct: 661 AEHAVLHLLYARFWHKVLYDLGHVSSREPYRRLINQGYIQAFAYTDAHGSYVPANQVFQR 720 Query: 575 ---------------YKDGAKMSKSKGNVVSPDEMIEKYGADTLRMYILFMAPPEKDAEW 619 +++ K+ KS N VSPDE+ ++YGADTLR+Y + M P E W Sbjct: 721 GDGFFCPGPDGEIEVFQEFGKIGKSLKNSVSPDEICDEYGADTLRVYEMSMGPLEASRPW 780 Query: 620 SDAGIEGVHRFVKRLWNTFYTVLPFVKEENTENLVLKNSTEKE--LRRKLHSIIKKITED 677 + + G +RF++R+W V E E V+ + E + R LH I +++D Sbjct: 781 ATKDVVGAYRFLQRVWRL------VVDERTGETRVVDTAGELDTYTLRTLHRTIAGVSQD 834 Query: 678 IEGGFKFNTAISGLMELVNHLS-QYLNSVPQEEWNRKLLREIVEKLTLALSPFAPHLAEE 736 + NTA + L+E NHL+ ++ SVP R VE L L L+P APHLAEE Sbjct: 835 Y-AALRNNTATAKLIEYTNHLTKEHRGSVP---------RVAVEPLVLMLAPLAPHLAEE 884 Query: 737 FWHDLGNDSLVVQQSWPSYDPKALEVEEVEIAIQINGKVRDKVVVPVDISEEDLKRIVLE 796 W LG+ + + +P DP L + VE +Q+NGK+R ++VV D + LK + L Sbjct: 885 LWLRLGHTTSLANGPFPQADPAYLVDDTVEYPVQVNGKIRGRIVVAADADYDTLKTVALA 944 Query: 797 RERVKEYVDGKPIRKFIYVKGRIVNIVV 824 ++V++++ G RK I V GR++++V+ Sbjct: 945 DDKVQQFLAGATPRKVIVVAGRLISLVI 972sp|P71698|SYL_MYCTU LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS) >gi|1568580|emb|CAB02520.1| (Z80775) leuS [Mycobacterium tuberculosis] Length = 969 Score = 552 bits (1408), Expect = e-156 Identities = 342/926 (36%), Positives = 464/926 (49%), Gaps = 160/926 (17%) Query: 33 KYYALVMFPYPSGT-LHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAENAAIE 91 K + MFPYPSG LHVGH Y+ D+ ARY RM G NVLH G+DAFGLPAE A++ Sbjct: 70 KLFVQDMFPYPSGEGLHVGHPLGYIATDVYARYFRMVGRNVLHALGFDAFGLPAEQYAVQ 129 Query: 92 KGIHPEEWTRKNIATIRQQVKKLGISYDWSREIATCDEEYYKWTQWIFLQLY-------- 143 G HP T N+ R+Q+ +LG +D R +T D ++Y+WTQWIFLQ+Y Sbjct: 130 TGTHPRTRTEANVVNFRRQLGRLGFGHDSRRSFSTTDVDFYRWTQWIFLQIYNAWFDTTA 189 Query: 144 ---------------------------------------KNGLAYKKKAAVNWCPKCKTV 164 + L Y+ + VNWCP TV Sbjct: 190 NKARPISELVAEFESGARCLDGGRDWAKLTAGERADVIDEYRLVYRADSLVNWCPGLGTV 249 Query: 165 LANEQVK-DGKCERCGTSVTIRHLEQWFFKITDYAERLLNDLDKLTGWPEHVKTMQRNWI 223 LANE+V DG+ +R V + L QW +IT YA+RLL+DLD L WPE VKTMQRNWI Sbjct: 250 LANEEVTADGRSDRGNFPVFRKRLRQWMMRITAYADRLLDDLDVLD-WPEQVKTMQRNWI 308 Query: 224 GKSTGAEIDFPV-----EGSDTKIRVFTTRPDTLWGVTFMXXXXXXXXXXXXXXXX---- 274 G+STGA F +G + I VFTTRPDTL+G T++ Sbjct: 309 GRSTGAVALFSARAASDDGFEVDIEVFTTRPDTLFGATYLVLAPEHDLVDELVAASWPAG 368 Query: 275 ------------XXXXXXXXXXRVKQQDRFRRTSVEAEKEGFFLGRYAINPVTGERIPIY 322 + D R+ S EK G FLG YAINP GE +PI+ Sbjct: 369 VNPLWTYGGGTPGEAIAAYRRAIAAKSDLERQES--REKTGVFLGSYAINPANGEPVPIF 426 Query: 323 VANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPIKVVIKPADKDLDPEKMEEAYEGEGI 382 +A+Y+L YGTGAIM VP HDQRD+ FA+ +G+PI VI + E AY G+GI Sbjct: 427 IADYVLAGYGTGAIMAVPGHDQRDWDFARAFGLPIVEVIAGGNIS------ESAYTGDGI 480 Query: 383 MVNSGPFDGTPSSEGIEKVINWLEEKGIGKRSVQYKLRDWLISRQRYWGAPIPIIYCEKC 442 +VNS +G +++ LE G G+ +++KLRDWL +RQRYWG P PI+Y Sbjct: 481 LVNSDYLNGMSVPAAKRAIVDRLESAGRGRARIEFKLRDWLFARQRYWGEPFPIVYDSDG 540 Query: 443 GVVPVPEEDLPVRLPKDVEFLPT----------GQSPLSFHEGFKKTKCPVCGG--EAQR 490 + E LPV LP ++ P PL+ + + G R Sbjct: 541 RPHALDEAALPVELPDVPDYSPVLFDPDDADSEPSPPLAKATEWVHVDLDLGDGLKPYSR 600 Query: 491 ETDTMDTFVDSSWYFLRYVNPHLEDKPFEPDDVNYWL-------------PVDQYIGGVE 537 +T+ M + SSWY LRY +PH ++ ++ YW+ VD Y+GG E Sbjct: 601 DTNVMPQWAGSSWYELRYTDPHNSERFCAKENEAYWMGPRPAEHGPDDPGGVDLYVGGAE 660 Query: 538 HAVLHLLYSRFVTKVLHDLGYLNFDEPFTNLFTQGMI----------------------- 574 HAVLHLLYSRF KVL+DLG+++ EP+ L QG I Sbjct: 661 HAVLHLLYSRFWHKVLYDLGHVSSREPYRRLVNQGYIQAYAYTDARGSYVPAEQVIERGD 720 Query: 575 -------------YKDGAKMSKSKGNVVSPDEMIEKYGADTLRMYILFMAPPEKDAEWSD 621 +++ K+ KS N VSPDE+ + YGADTLR+Y + M P E W+ Sbjct: 721 RFVYPGPDGEVEVFQEFGKIGKSLKNSVSPDEICDAYGADTLRVYEMSMGPLEASRPWAT 780 Query: 622 AGIEGVHRFVKRLWNTFYTVLPFVKEENTENLVLKNSTEKEL--RRKLHSIIKKITEDIE 679 + G +RF++R+W V +E+T + + E ++ R LH I ++ED Sbjct: 781 KDVVGAYRFLQRVWR-------LVVDEHTGETRVADGVELDIDTLRALHRTIVGVSEDF- 832 Query: 680 GGFKFNTAISGLMELVNHLS-QYLNSVPQEEWNRKLLREIVEKLTLALSPFAPHLAEEFW 738 + NTA + L+E NHL+ ++ ++VP R VE L L+P APH+AEE W Sbjct: 833 AALRNNTATAKLIEYTNHLTKKHRDAVP---------RAAVEPLVQMLAPLAPHIAEELW 883 Query: 739 HDLGNDSLVVQQSWPSYDPKALEVEEVEIAIQINGKVRDKVVVPVDISEEDLKRIVLERE 798 LGN + + +P D L E VE +Q+NGKVR +VVV D EE LK VL E Sbjct: 884 LRLGNTTSLAHGPFPKADAAYLVDETVEYPVQVNGKVRGRVVVAADTDEETLKAAVLTDE 943 Query: 799 RVKEYVDGKPIRKFIYVKGRIVNIVV 824 +V+ ++ G RK I V GR+VN+V+ Sbjct: 944 KVQAFLAGATPRKVIVVAGRLVNLVI 969ref|NP_013486.1|NAM2| mitochondrial leucyl tRNA synthetase; Nam2p >gi|135144|sp|P11325|SYLM_YEAST LEUCYL-TRNA SYNTHETASE, MITOCHONDRIAL PRECURSOR (LEUCINE--TRNA LIGASE) (LEURS) >gi|68518|pir||SYBYLM leucine--tRNA ligase (EC 6.1.1.4) precursor, mitochondrial - yeast (Saccharomyces cerevisiae) >gi|4021|emb|CAA28791| (X05143) ORF2 (AA 1-894) for mitochon- drial leucyl tRNA synthetase [Saccharomyces cerevisiae] >gi|172008 (J03495) leucyl-tRNA synthetase [Saccharomyces cerevisiae] >gi|609429 (U19104) Nam2p: mitochondrial leucyl-tRNA synthetase [Saccharomyces cerevisiae] Length = 894 Score = 549 bits (1400), Expect = e-155 Identities = 319/849 (37%), Positives = 461/849 (53%), Gaps = 86/849 (10%) Query: 35 YALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAENAAIEKGI 94 Y L FPYPSG LH+GH++ YVI D + R+ + +GYNV+HP G+DAFGLPAENAAIE+ I Sbjct: 50 YILCQFPYPSGALHIGHLRVYVISDSLNRFYKQKGYNVIHPMGWDAFGLPAENAAIERSI 109 Query: 95 HPEEWTRKNIATIRQQVKKLGISYDWSREIATCDEEYYKWTQWIFLQLYKNGLAYKKKAA 154 +P WTR NIA ++QQ++ + ++DW REI TCD EYYK+TQWIFL+L++NGLAY+K+A Sbjct: 110 NPAIWTRDNIAKMKQQMQSMLANFDWDREITTCDPEYYKFTQWIFLKLFENGLAYRKEAE 169 Query: 155 VNWCPKCKTVLANEQV-KDGKCERCGTSVTIRHLEQWFFKITDYAERLLNDLDKLTGWPE 213 +NW P TVLANEQV G+ R G V + L+QWF IT +A +L L++L WP Sbjct: 170 INWDPVDMTVLANEQVDAQGRSWRSGAIVEKKQLKQWFLGITKFAPKLKKHLNQLKDWPS 229 Query: 214 HVKTMQRNWIGKSTGAEIDFPVEGSDTKIR---VFTTRPDTLWGVTFMXXXXXXXXXXXX 270 +VK MQ+NWIG+S GAE+ F V +D K VFTTRP+TL+ V ++ Sbjct: 230 NVKQMQKNWIGESVGAELVFKV--ADPKFENLIVFTTRPETLFAVQYVALALDHPIVQKY 287 Query: 271 XXXXXXXXXXXXXXRVKQQDRFRRTSVEAEKEGFFLGRY-AINPVTGERIPIYVANYILM 329 +++ D+ + KEGF L A+NP+T E +PI+ A Y++ Sbjct: 288 CEEMPDLKEF-----IQKSDQLPNDT----KEGFQLPNIKAVNPLTKEEVPIFAAPYVVS 338 Query: 330 EYGT--GAIMGVPAHDQRDFSFAKKY--GIPIKVVIKPADKDLDPEKMEEAY-------- 377 YG+ A+MG P HD RDF F + G IK I P D +E Sbjct: 339 SYGSAPSAVMGCPGHDNRDFEFWQTNCPGEHIKTCIAPFFDDASKVTEQERQRIIDTVPF 398 Query: 378 -EGEGIMVNS-GPFDGTPSSEGIEKVINWLEEKGIGKRSVQYKLRDWLISRQRYWGAPIP 435 +G++ G G + + ++ L +G+ K V+YK+RDWLISRQRYWG PIP Sbjct: 399 TSTDGVLTKECGEHSGVLTVVARKSIMGMLNSEGLSKSVVRYKIRDWLISRQRYWGTPIP 458 Query: 436 IIYCEKCGVVPVPEEDLPVRLPKDVEFLPTGQSPLSFHEGFKKTKCPVCGGEAQRETDTM 495 II+C+ CG VPVPE DLPV+LP ++E L T +PLS + F CP CG A+RETDTM Sbjct: 459 IIHCDNCGPVPVPESDLPVKLP-ELEGLDTKGNPLSTIDEFVNVACPSCGSPAKRETDTM 517 Query: 496 DTFVDSSWYFLRYVNPHLEDKPFEPDDVNYWLPVDQYIGGVEHAVLHLLYSRFVTKVLHD 555 DTF+DSSWY+ R+++P KPF+ + + +PVD YIGGVEHA+LHLLYSRF+ K L Sbjct: 518 DTFIDSSWYYFRFLDPKNTSKPFDREIASKNMPVDIYIGGVEHAILHLLYSRFIAKFLGS 577 Query: 556 LGY----LNFDEPFTNLFTQGMIY------------------------KDG--------- 578 + EPF L TQGM+ DG Sbjct: 578 INAWSDPAGIFEPFKKLVTQGMVQGKTYVDPDSGKFLKPDELTFVNDSPDGNTVIIKSNG 637 Query: 579 -------AKMSKSKGNVVSPDEMIEKYGADTLRMYILFMAPPEKDAEWSDAGIEGVHRFV 631 KMSKSK N P+E I ++G D R +ILF +P W ++ I G+ R++ Sbjct: 638 KVPVVSYEKMSKSKYNGADPNECILRHGPDATRAHILFQSPIADALNWDESKIVGIERWL 697 Query: 632 KRLWNTFYTVLPFVKE----ENTENLVLKNSTEKELRRKLHSIIKKITEDIEGGFKFNTA 687 +++ + +L K+ ++ + N E + +K ITE E NT Sbjct: 698 QKVLHLTKNILSLEKDLAISKDYKTPTDLNDAEVKFHNDFQRFLKSITESFEVNLSLNTV 757 Query: 688 ISGLMELVNHLSQYLNSVPQEEWNRKLLREIVEKLTLALSPFAPHLAEEFWHDLGNDSLV 747 IS M+L N L +++ + E +++ + ++KL + P P ++EE + + Sbjct: 758 ISDYMKLTNILE---SALKKGEVRNEMIVQNLQKLVTVIYPAVPSISEEAAEMINSQMEW 814 Query: 748 VQQSWPSYDPKALEVEEVEIAIQINGKVRDKVVVP---VDISEEDLKRIVLERERVKEYV 804 Q WP + + E + + I +NG+V+ + + + + ++ + Y+ Sbjct: 815 NQYRWPEVE-RTTESKFKKFQIVVNGRVKFMYTADKNFLKLGRDAVIETLMNLPEGRMYL 873 Query: 805 DGKPIRKFI 813 K I+KF+ Sbjct: 874 MNKKIKKFV 882sp|Q15031|SYLM_HUMAN PROBABLE LEUCYL-TRNA SYNTHETASE, MITOCHONDRIAL PRECURSOR (LEUCINE--TRNA LIGASE) (LEURS) (KIAA0028) >gi|2104217|dbj|BAA04877| (D21851) KIAA0028 [Homo sapiens] Length = 903 Score = 534 bits (1360), Expect = e-150 Identities = 312/859 (36%), Positives = 448/859 (51%), Gaps = 103/859 (11%) Query: 31 KPKYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAENAAI 90 KPK+Y L MFPYPSG LH+GHV+ Y I D +AR+++MRG V++P G+DAFGLPAENAA+ Sbjct: 81 KPKFYVLSMFPYPSGKLHMGHVRVYTISDTIARFQKMRGMQVINPMGWDAFGLPAENAAV 140 Query: 91 EKGIHPEEWTRKNIATIRQQVKKLGISYDWSREIATCDEEYYKWTQWIFLQLYKNGLAYK 150 E+ +HP+ WT+ NI +R+Q+ +LG+ + W REI TC +YYKWTQ++F++LY+ GLAY+ Sbjct: 141 ERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQ 200 Query: 151 KKAAVNWCPKCKTVLANEQVKDGKCE-RCGTSVTIRHLEQWFFKITDYAERLLNDLDKLT 209 K+A VNW P +TVLANEQV + C R G V ++L QWF K T YA+ + + L L Sbjct: 201 KEALVNWDPVDQTVLANEQVDEHGCSWRSGAKVEQKYLRQWFIKTTAYAKAMQDALADLP 260 Query: 210 GWPEHVKTMQRNWIGKSTGAEIDFPV----EGSDTKIRVFTTRPDTLWGVTFMXXXXXXX 265 W +K MQ +WIG G +DF + + + K+ +T P+ ++G + + Sbjct: 261 EW-YGIKGMQAHWIGDCVGCHLDFTLKVHGQATGEKLTAYTATPEAIYGTSHVAISPSHR 319 Query: 266 XXXXXXXXXXXXXXXXXXXRVKQQDRFRRTSVEAEKEGFFLGRYAINPVTGERIPIYVAN 325 ++ R V + A+N +T + +P+ + Sbjct: 320 LLHGHSSL---------------KEALRMALVPG--KDCLTPVMAVNMLTQQEVPVVILA 362 Query: 326 YILMEYGTGAIMGVPAHDQRDFSFAKKYGIPIKVVIKPADKDLDPEKMEEAYEGEGIMVN 385 +E + +G+P+ D A+ G+ VI E +G + + Sbjct: 363 KADLEGSLDSKIGIPSTSSEDTILAQTLGLAYSEVI------------ETLPDGTERLSS 410 Query: 386 SGPFDGTPSSEGIEKVINWLEEKGIGKRSVQYKLRDWLISRQRYWGAPIPIIYCEKCGVV 445 S F G + + K +G KL+DWLISRQRYWG PIPI++C CG Sbjct: 411 SAEFTGMTRQDAFLALTQKARGKRVGGDVTSDKLKDWLISRQRYWGTPIPIVHCPVCGPT 470 Query: 446 PVPEEDLPVRLPKDVEFLPTGQSPLSFHEGFKKTKCPVCGGEAQRETDTMDTFVDSSWYF 505 PVP EDLPV LP F G PL+ + CP C G A+RETDTMDTFVDS+WY+ Sbjct: 471 PVPLEDLPVTLPNIASFTGKGGPPLAMASEWVNCSCPRCKGAAKRETDTMDTFVDSAWYY 530 Query: 506 LRYVNPHLEDKPFEPDDVNYWLPVDQYIGGVEHAVLHLLYSRFVTKVLHDLGYLNFDEPF 565 RY +PH PF +YW+PVD YIGG EHAV+HL Y+RF + HD + EPF Sbjct: 531 FRYTDPHNPHSPFNTAVADYWMPVDLYIGGKEHAVMHLFYARFFSHFCHDQKMVKHREPF 590 Query: 566 TNLFTQGMIYKD----------------------------------GAKMSKSKGNVVSP 591 L QG+I KMSKSK N V P Sbjct: 591 HKLLAQGLIKGQTFRLPSGQYLQREEVDLTGSVPVHAKTKEKLEVTWEKMSKSKHNGVDP 650 Query: 592 DEMIEKYGADTLRMYILFMAPPEKDAEW---SDAGIEGVHRFVKRLWNTFYTVLPFVKEE 648 +E++E+YG DT+R+YILF APPEKD W +DA + GV R+ +RLW + Sbjct: 651 EEVVEQYGIDTIRLYILFAAPPEKDILWDVKTDA-LPGVLRWQQRLWTLTTRFIEARASG 709 Query: 649 NTENLVLKNSTEKELRRKL----HSIIKKITEDIEGGFKFNTAISGLMELVNHLSQYLNS 704 + L ++ EK RKL +S+I ++T F N+AIS LM L N LSQ S Sbjct: 710 KSPQPQLLSNKEKAEARKLWEYKNSVISQVTTHFTEDFSLNSAISQLMGLSNALSQASQS 769 Query: 705 V----PQEEWNRKLLREIVEKLTLALSPFAPHLAEEFWHDLGN-----------DSLVVQ 749 V P+ E + + L + +P APH+ E W L D+ V+ Sbjct: 770 VILHSPEFE-------DALCALMVMAAPLAPHVTSEIWAGLALVPRKLCAHYTWDASVLL 822 Query: 750 QSWPSYDPKALEVEE-VEIAIQINGKVRDKVVVPVDIS--EEDLKRIVLERERVKEYVDG 806 Q+WP+ DP+ L+ E V++A+ IN K K+ VP ++ ++ + VL+ E + G Sbjct: 823 QAWPAVDPEFLQQPEVVQMAVLINNKACGKIPVPQQVARDQDKVHEFVLQSELGVRLLQG 882 Query: 807 KPIRK-FIYVKGRIVNIVV 824 + I+K F+ + ++N +V Sbjct: 883 RSIKKSFLSPRTALINFLV 901sp|P75398|SYL_MYCPN LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS) >gi|2146327|pir||S73779 leucine--tRNA ligase (EC 6.1.1.4) leuS - Mycoplasma pneumoniae (SGC3) (ATCC 29342) >gi|1674141 (AE000044) Mycoplasma pneumoniae, leucyl-tRNA synthetase; similar to Swiss-Prot Accession Number P36430, from B. subtilis [Mycoplasma pneumoniae] Length = 793 Score = 501 bits (1275), Expect = e-140 Identities = 300/814 (36%), Positives = 438/814 (52%), Gaps = 72/814 (8%) Query: 31 KPKYYALVMFPYPSGT-LHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAENAA 89 KPKYY L MFPYPS LH+GHV+ Y I D+++RY + +G+NV+HP G+DAFGLPAE A Sbjct: 29 KPKYYILDMFPYPSAAGLHLGHVRAYTITDVLSRYHKAKGFNVIHPIGFDAFGLPAEQYA 88 Query: 90 IEKGIHPEEWTRKNIATIRQQVKKLGISYDWSREIATCDEEYYKWTQWIFLQLYKNGLAY 149 I HP +WT KNI +Q+ G YD+ + T D YY++TQWIF QL++ GLA Sbjct: 89 IASNKHPGDWTDKNITNFIEQLTAFGFDYDYQLSLKTTDPRYYQYTQWIFGQLFEAGLAE 148 Query: 150 KKKAAVNWCPKCKTVLANEQV-----KDGKCERCGTSVTIRHLEQWFFKITDYAERLLND 204 K+ VNWC + TVLANE+V + ER VT R ++QW KIT +AE LLN Sbjct: 149 VKEIDVNWCAELGTVLANEEVLIDSNGNAVSERGEFPVTKRKMKQWVLKITAFAESLLNG 208 Query: 205 LDKLTGWPEHVKTMQRNWIGKSTGAEIDFPVEGSDTKIRVFTTRPDTLWGVTFMXXXXXX 264 L +L W + +K MQ NWIGKS G E+ F +E S I +FTT+ T++GVTF+ Sbjct: 209 LAEL-DWHQSIKEMQTNWIGKSEGVEVTFDIENSKETITIFTTKVQTIFGVTFL------ 261 Query: 265 XXXXXXXXXXXXXXXXXXXXRVKQQDRFRRTSV---EAEKEGFFLGRYAINPVTGERIPI 321 + Q+ + T+V E +G L AINP T IP+ Sbjct: 262 ALSNSHPLVKEVAKTNPKIAQFLQKQAQKTTTVKQPETLHDGVDLKLKAINPATNTAIPL 321 Query: 322 YVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPIKVVIKPADKDLDPEKMEEAYEGEG 381 YVANY++ YGT A+MGVPAH++ D FA+K +PI VI ++ Sbjct: 322 YVANYVVEGYGTDAVMGVPAHNENDNFFARKQKLPIITVIDKQER--------------- 366 Query: 382 IMVNSGPFDGTPSSEGIEKVINWLEEKGIGKRSVQYKLRDWLISRQRYWGAPIPIIYCEK 441 + +SG F G S ++ L E+ K++ YKLRDW+ SRQRYWG P PI++ E Sbjct: 367 -LQHSGQFSGLNSQTANTQITQMLVERQKAKKTTVYKLRDWIFSRQRYWGEPFPILFDE- 424 Query: 442 CGVVPVPEEDLPVRLPKDVEFLPTGQS--PLSFHEGFKKTKCPVCGGEA-QRETDTMDTF 498 P ++LPV LP + P G + PL ++ + K K G + RET TM + Sbjct: 425 -NNQPHLVKELPVTLPALANYQPDGSTNPPLWRNQEWAKVK---QGNQTFTRETSTMPQW 480 Query: 499 VDSSWYFLRYVNPHLEDKPFEPDD-------VNYWLPVDQYIGGVEHAVLHLLYSRFVTK 551 S WY+L Y+ + ++ F P D +LPVD Y+GG EHAVLHLLY+RF + Sbjct: 481 AGSCWYYLGYL-MLINNENFWPIDSREAKDLFERYLPVDLYVGGAEHAVLHLLYARFWHQ 539 Query: 552 VLHDLGYLNFDEPFTNLFTQGMIY-KDGAKMSKSKGNVVSPDEMIEKYGADTLRMYILFM 610 L+ G + EPF L QGM+ DG KMSKSKGN ++P +I+ +GAD LR+Y++FM Sbjct: 540 FLYQKGIVTTKEPFKKLINQGMVLGPDGKKMSKSKGNTINPTPLIDSHGADALRLYLMFM 599 Query: 611 APPEKDAEWSDAGIEGVHRFVKRLWNTFYTVLPFVKEENTENLVLKNSTEKELRRKLHSI 670 P W D G+ G+ R++ R+ N F+ +EN ++K + ++E + Sbjct: 600 GPISAALTWLDDGLNGMRRWLDRVHNFFH-------KEN----IIKETVDQETVYGYNLF 648 Query: 671 IKKITEDIEGGFKFNTAISGLMELVNHLSQYLNSVPQEEWNRKLLREIVEKLTLALSPFA 730 +K+ E +E + N IS +M +N L + ++L + LS FA Sbjct: 649 LKRSFEHLEKQ-ELNLVISQMMIFLNLLYK----------TKQLTLAYAKGFLTVLSFFA 697 Query: 731 PHLAEEFWHDLGNDSLVVQQSWPSYDPKALEVEEVEIAIQINGKVRDKVVVPVDISEEDL 790 P+LAEE LG + +V P+ D LE ++V+I + +NG+ + + E+ + Sbjct: 698 PYLAEELNAKLGMEPFIVHAQLPNVDNSVLETDKVKIILSVNGRFKGTKEFAKGVDEQTV 757 Query: 791 KRIVLERERVKEYVDGKPIRKFIYVKGRIVNIVV 824 + + D +P+ + ++V RI+N+++ Sbjct: 758 LKAFKTDPEFQALFD-QPLARVVFVPNRIINVLL 790sp|P47508|SYL_MYCGE LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS) >gi|1361707|pir||D64229 leucine--tRNA ligase (EC 6.1.1.4) - Mycoplasma genitalium (SGC3) >gi|3844862 (U39706) leucyl-tRNA synthetase (leuS) [Mycoplasma genitalium] Length = 792 Score = 480 bits (1222), Expect = e-134 Identities = 305/824 (37%), Positives = 436/824 (52%), Gaps = 88/824 (10%) Query: 29 SEKPKYYALVMFPYPSGT-LHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAEN 87 S K KYY L MFPYPS LH+GHV+ Y I D+++RY + +G+NV+HP G+DAFGLPAE Sbjct: 27 SNKKKYYVLDMFPYPSAAGLHLGHVRAYTITDVISRYYKAKGFNVIHPIGFDAFGLPAEQ 86 Query: 88 AAIEKGIHPEEWTRKNIATIRQQVKKLGISYDWSREIATCDEEYYKWTQWIFLQLYKNGL 147 AI +P WT +NI Q+ G YD+ + T D YYK+TQWIF +L+K L Sbjct: 87 YAINSNQNPGSWTDQNINNFINQLTSFGFDYDYHLSLKTTDPRYYKYTQWIFSELFKANL 146 Query: 148 AYKKKAAVNWCPKCKTVLANEQV-----KDGKCERCGTSVTIRHLEQWFFKITDYAERLL 202 A VNWC + TVLANE+V + ER SV R ++QW KIT +A+ LL Sbjct: 147 AELVDIDVNWCEQLGTVLANEEVLIDSNGNAVSERGSFSVEKRKMKQWVLKITTFADALL 206 Query: 203 NDLDKLTGWPEHVKTMQRNWIGKSTGAEIDFPVEGSDTKIRVFTTRPDTLWGVTFMXXXX 262 LD L WPE +K MQRNWIGKS G I+F ++ I +FTT+P T++GV+F+ Sbjct: 207 EGLDTL-DWPEPIKEMQRNWIGKSKGVTINFQLKDHKEAIAIFTTKPQTIFGVSFLAVST 265 Query: 263 XXXXXXXXXXXXXXXXXXXXXXRVKQQDRFRRTSVEAEK----EGFFLGRYAINPVTGER 318 +K+Q ++T+ +K +G L AI+P+T E Sbjct: 266 NHWLAKKIAETNKKVASF-----LKKQ--LQKTTTLKQKATLYDGIDLLTNAIHPLTNEL 318 Query: 319 IPIYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPIKVVIKPADKDLDPEKMEEAYE 378 IP+YVANY++ YGT AIMGV AH++ D FA+K + I VI ++ Sbjct: 319 IPVYVANYVIEGYGTDAIMGVGAHNENDNFFARKQKLKIINVIDKKER------------ 366 Query: 379 GEGIMVNSGPFDGTPSSEGIEKVINWLEEKGIGKRSVQYKLRDWLISRQRYWGAPIPIIY 438 + NS ++G + E + N L + K + YKLRDW+ SRQRYWG P PII+ Sbjct: 367 ----LQNSFAYNGLTTKEAQVAITNELISQNKAKLTTVYKLRDWIFSRQRYWGEPFPIIF 422 Query: 439 CEKCGVVPVPEEDLPVRLPKDVEFLP--TGQSPLSFHEGFKKTKCPVCGGEAQRETDTMD 496 E P E LPV LP + P +G SPL ++ + QRET+TM Sbjct: 423 DE--NNTPHLVEQLPVELPLLENYKPDGSGNSPLMRNQAW--VNIVKDNIHYQRETNTMP 478 Query: 497 TFVDSSWYFLRYVNPHLEDKPFEPDD-------VNYWLPVDQYIGGVEHAVLHLLYSRFV 549 + S WY+L Y+ +++ F P D + +LPVD Y+GG EHAVLHLLY+RF Sbjct: 479 QWAGSCWYYLGYL-MLIKNPNFWPIDSKEAKKLFDQYLPVDLYVGGAEHAVLHLLYARFW 537 Query: 550 TKVLHDLGYLNFDEPFTNLFTQGMIY-KDGAKMSKSKGNVVSPDEMIEKYGADTLRMYIL 608 K L D ++ EPF L QGM+ DG KMSKSKGN ++P +++ +GAD LR+Y++ Sbjct: 538 HKFLFDKKLVSTKEPFQKLINQGMVLGPDGKKMSKSKGNTINPTPLVDSHGADALRLYLM 597 Query: 609 FMAPPEKDAEWSDAGIEGVHRFVKRLWNTFY---TVLPFVKEEN--TENLVLKNSTEKEL 663 FM P W+D G+ G+ R++ R++N F+ V V +E NL LKNS Sbjct: 598 FMGPISASLTWNDEGLNGMRRWLDRVYNFFFNHAVVTDQVSQETIFAYNLFLKNS----- 652 Query: 664 RRKLHSIIKKITEDIEGGFKFNTAISGLMELVNHLSQYLNSVPQEEWNRKLLREIVEKLT 723 + + K + N IS +M +N L + +K+ + Sbjct: 653 ----YCHLDK--------HELNLVISEMMIFLNFLYK----------TKKISLNYAKGFL 690 Query: 724 LALSPFAPHLAEEFWHDLGNDSLVVQQSWPSYDPKALEVEEVEIAIQINGKVRDKVVVPV 783 LS FAP LAEE G + VV+Q+ D + E + ++ + INGK + Sbjct: 691 TVLSFFAPFLAEELNEKCGLEPFVVKQAISLVDYQLFETAKTKVILSINGKFK----AAK 746 Query: 784 DISEEDLKRIVLER-ERVKEYVD--GKPIRKFIYVKGRIVNIVV 824 + ++ L+ VLE ++ KE D +PI + +YV+ RI+N+++ Sbjct: 747 EFTKGSLEIDVLESFKQDKEINDILNQPIERVVYVQDRIINVLL 790emb|CAA94727| (Z70722) leucyl-tRNA synthase [Mycobacterium leprae] Length = 824 Score = 434 bits (1105), Expect = e-120 Identities = 265/736 (36%), Positives = 359/736 (48%), Gaps = 142/736 (19%) Query: 33 KYYALVMFPYPSGT-LHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAENAAIE 91 K + MFPYPSG LHVGH Y+ D+ ARY RM G+NVLH G+DAFGLPAE A++ Sbjct: 70 KLFVQDMFPYPSGDGLHVGHPLGYIATDVYARYFRMTGHNVLHAMGFDAFGLPAEQYAMQ 129 Query: 92 KGIHPEEWTRKNIATIRQQVKKLGISYDWSREIATCDEEYYKWTQWIFLQLYKNG----- 146 G HP T N+ R Q+ +LG+ +D R +T D E+YKWTQWIFLQ+Y Sbjct: 130 TGTHPRILTEANVVNFRHQLGRLGLGHDSRRTFSTTDVEFYKWTQWIFLQIYNAWFDVAA 189 Query: 147 ------------------------------------------LAYKKKAAVNWCPKCKTV 164 L Y+ + VNWCP TV Sbjct: 190 NKARPIAELIAEFDSGERRLVDGRDWATLSAGERADVIDNCRLVYRADSMVNWCPGLGTV 249 Query: 165 LANEQVK-DGKCERCGTSVTIRHLEQWFFKITDYAERLLNDLDKLTGWPEHVKTMQRNWI 223 LANE+V DG+ +R V + L QW +IT YA+RLL+DLD L WPE VKTMQRNWI Sbjct: 250 LANEEVTADGRSDRGNFPVFRKRLRQWMMRITAYADRLLDDLD-LLDWPEQVKTMQRNWI 308 Query: 224 GKSTGAEIDFPV-------EGSDTKIRVFTTRPDTLWGVTFMXXXXXXXXX--------- 267 G+S+GA + F ++ + VFTTRPDT++GVT++ Sbjct: 309 GRSSGATVLFSAILSRSDAATTEVDVEVFTTRPDTMFGVTYLVLAPEHNLVDELVATVWP 368 Query: 268 -------XXXXXXXXXXXXXXXXXRVKQQDRFRRTSVEAEKEGFFLGRYAINPVTGERIP 320 V + D R+ S EK G FLGRYA NP TG+ +P Sbjct: 369 DRTDPRWTYGAATPGAAVAAYRRAIVAKSDLDRQES--KEKTGVFLGRYATNPATGKPVP 426 Query: 321 IYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPIKVVIKPADKDLDPEKMEEAYEGE 380 I+VA+Y+L+ YGTGA+M VP HD RD+ FA K+ +PI VI +D E AY G+ Sbjct: 427 IFVADYVLVGYGTGAVMAVPGHDPRDWDFAHKFHLPIVEVIAGSDIS------EAAYVGD 480 Query: 381 GIMVNSGPFDGTPSSEGIEKVINWLEEKGIGKRSVQYKLRDWLISRQRYWGAPIPIIYCE 440 G++VNSG DG + E + LE +G G +++KLRDWL +RQRYWG P PIIY Sbjct: 481 GVLVNSGYLDGMDVATAQEAITARLESEGRGHARIEFKLRDWLFARQRYWGEPFPIIYDS 540 Query: 441 KCGVVPVPEEDLPVRLPKDVEFLPT----------GQSPLSFHEGFKKTKCPVCGG--EA 488 + E LPV LP + P PL+ + + + G Sbjct: 541 DGRPHALDEAALPVELPDVPYYSPVLFDPDDADSEPSPPLAKATEWVHVELDLGDGLKPY 600 Query: 489 QRETDTMDTFVDSSWYFLRYVNPHLEDKPFEPDDVNYWL-------------PVDQYIGG 535 R+T+ M + SSWY LRY +PH ++ ++ YW+ VD Y+ Sbjct: 601 SRDTNVMPQWAGSSWYELRYTDPHNSERLCAKENEAYWMGPRPTEHGIDDPGGVDLYVAE 660 Query: 536 VEHAVLHLLYSRFVTKVLHDLGYLNFDEPFTNLFTQGMI--------------------- 574 LY+RF KVL+DLG+++ EP+ L QG I Sbjct: 661 PNMRCYICLYARFWHKVLYDLGHVSSREPYRRLINQGYIQAFAYTDAHGSYVPANQVFQR 720 Query: 575 ---------------YKDGAKMSKSKGNVVSPDEMIEKYGADTLRMYILFMAPPEKDAEW 619 +++ K+ KS N VSPDE+ ++YGADTLR+Y + M P E W Sbjct: 721 GDGFFCPGPDGEIEVFQEFGKIGKSLKNSVSPDEICDEYGADTLRVYEMSMGPLEASRPW 780 Query: 620 SDAGIEGVHRFVKRLW 635 + + G +RF++R+W Sbjct: 781 ATKDVVGAYRFLQRVW 796emb|CAA98144.2| (Z73912) predicted using Genefinder; Similarity to Yeast leucyl-tRNA synthetase (mitochonrial) (SW:SYLM_YEAST); cDNA EST EMBL:D65204 comes from this gene; cDNA EST EMBL:D65425 comes from this gene; cDNA EST EMBL:D68553 comes ... Length = 835 Score = 337 bits (856), Expect = 2e-91 Identities = 239/815 (29%), Positives = 365/815 (44%), Gaps = 122/815 (14%) Query: 33 KYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAENAAIEK 92 K Y L MFPYPSG LH+GH++ Y I D ARY R+ GY V+HP G+D+FGLPAENAA +K Sbjct: 27 KKYILSMFPYPSGRLHIGHMRVYTISDATARYYRLNGYEVIHPIGWDSFGLPAENAARDK 86 Query: 93 GIHPEEWTRKNIATIRQQVKKLGISYDWSREIATCDEEYYKWTQWIFLQLYKNGLAYKKK 152 G+ P EWT NI +++QQ+ K I +DW +EI+TC+ E+++WTQWIF +L++ GL + Sbjct: 87 GVDPREWTINNIESMKQQLLKTKILFDWEKEISTCEPEFFRWTQWIFCKLFEYGLVKRTS 146 Query: 153 AAVNWCPKCKTVLANEQV-KDGKCERCGTSVTIRHLEQWFFKITDYAERLLNDLDKLTGW 211 + VNW P KTVLA EQ+ DGK R G + L QW + YA+RL L K++ Sbjct: 147 SEVNWDPIDKTVLAAEQIDNDGKSWRSGAKAEKKKLSQWMIETPKYAKRLQEGLRKMSEQ 206 Query: 212 PEHVKTMQRNWIGKSTGAEIDFPVEGSDTKIRVFTTRPDTLWGVTFMXXXXXXXXXXXXX 271 V +Q NWIGK PV + + R ++ ++ Sbjct: 207 WGEVADIQANWIGKCDVYRFMLPVMKDGSNDEIIDLRIKDIFEIS--------------- 251 Query: 272 XXXXXXXXXXXXXRVKQQDRFRRTSVEAEKEGFFLGRYAINPVTGERIPIYVANYILMEY 331 +KQ +A + + L +N VTG +IP+ V Sbjct: 252 --------NAEFLVLKQSHSL--ADKDATQFPYKLPFQVLNGVTGRQIPVIVVEDTYQPD 301 Query: 332 GTGAIMGVPAHDQRDFSFAKKYGIPIKVVIKPADKDLDPEKMEEAYEGEGIMVNSGPFDG 391 T + + Q+D +K I + VI + + +++A+ Sbjct: 302 VTSFLNSRIGNFQKDKILVEKKWIISECVI---FCNFFKKNIQKAFTN------------ 346 Query: 392 TPSSEGIEKVINWLEEKGIGKRSVQYKLRDWLISRQRYWGAPIPIIYCEKCGVVPVPEED 451 N + G G L DW++SRQR WG PIP+I + V V Sbjct: 347 ----------ANNFQFGGYGGYETSRTLTDWVVSRQRGWGTPIPMIQTKDGKRVAVQLNK 396 Query: 452 LPVRLPKDVEFLPTGQSPLSFHEGFKKTKCPVCGGEAQRETDTMDTFVDSSWYFLRYVNP 511 LPV L + + E F G +TDT+DTF DS+WY+LRY++ Sbjct: 397 LPV--------LGSDRGQEVDKERF--------GESGVFDTDTLDTFFDSAWYYLRYLDN 440 Query: 512 HLEDKPFEPDDVNYWLPVDQYIGGVEHAVLHLLYSRFVTKVLHDLGYLNFDEPFTNLFTQ 571 + + + +PVD Y+GG+EHA +H+ ++RFV L D+ + EPFT+L Q Sbjct: 441 KNKSELISKGAMKN-MPVDVYVGGIEHAAVHMFFARFVAYFLKDINVIQTAEPFTDLIPQ 499 Query: 572 GM-------------------IYKDG-----------------AKMSKSKGNVVSPDEMI 595 G+ + + G KMSKSK N V ++ Sbjct: 500 GIVRGKTFIEKETGKYLGSEDVQQSGDKLTLKNDSSVEVDAVYEKMSKSKNNGVDLAAIL 559 Query: 596 EKYGADTLRMYILFMAPPEKDAEWSDAGIEGVHRFVKRLWNTFYTVLPFVKEENTENLVL 655 + G D R+ +L A P W + ++G+ + + R+ ++ +N + + L Sbjct: 560 DSEGVDMTRLRLLEAAAPRAPINWGETDLKGIKKLLDRIAAINSQIVD--ARDNGKPIEL 617 Query: 656 KNSTEKELRRKLHSIIKKITEDIEGGFKFNTAISGLMELVNHLSQ----YLNSVPQEEWN 711 K + ++ + ++ + +E NTA+ + N L + YL P+ + Sbjct: 618 KKEIDGSIKETYNFFVRNVGMCLEVLHLHNTALMRIQGFTNALKKVDPIYLAHSPEGQ-- 675 Query: 712 RKLLREIVEKLTLALSPFAPHLAEEFWHDLGND-SLVVQQSWPSYDPKALEVEEVEIAIQ 770 V+ L + L F PH+A E W L ND SLV Q WP D A ++E + Sbjct: 676 -----RAVKSLIIMLQVFCPHVASEMWSALANDGSLVSDQKWPEVDKDA----DIEFLLM 726 Query: 771 INGKVRDKVVVPVDISEEDLKRIVLERERVKEYVD 805 I+G + + I EE + ER E+ D Sbjct: 727 IDGVSGGRPSLDRRIIEEMSMDQLWERATFYEHAD 761gi|2984068 (AE000755) leucyl-tRNA synthetase beta subunit [Aquifex aeolicus] Length = 289 Score = 254 bits (643), Expect = 2e-66 Identities = 126/250 (50%), Positives = 172/250 (68%), Gaps = 5/250 (2%) Query: 577 DGAKMSKSKGNVVSPDEMIEKYGADTLRMYILFMAPPEKDAEWSDAGIEGVHRFVKRLWN 636 + AKMSKSK NVV P+E +EKYGADT+R+YILF APPE+D EW+D GI+G +RF++R WN Sbjct: 42 ESAKMSKSKANVVDPEEAVEKYGADTVRLYILFAAPPEQDFEWTDEGIQGAYRFLQRYWN 101 Query: 637 TFYTVLPFVKE--ENTENLVLKNSTEKELRRKLHSIIKKITEDIEGGFKFNTAISGLMEL 694 L +K E L KE+RR++H I D E ++FNTAI+ +M+L Sbjct: 102 FVNKHLEKIKNLTYTVEELRNVQGKAKEVRREIHQTIADYRRDFEERYQFNTAIAKIMKL 161 Query: 695 VNHLSQYLNSVPQEEWNRKLLREIVEKLTLALSPFAPHLAEEFWHDLGNDSLVVQQSWPS 754 +N L + PQ E + K+LRE +E +TL LSP PH+AEE W LGN+ ++ Q P Sbjct: 162 LNTLQDFS---PQTEQDYKVLREGIETITLLLSPITPHIAEEVWEMLGNEGFIINQPIPE 218 Query: 755 YDPKALEVEEVEIAIQINGKVRDKVVVPVDISEEDLKRIVLERERVKEYVDGKPIRKFIY 814 DP+AL+VEE+EI +Q+NGK+R +V VP D EE +K IVL ERV+++V GK ++KFIY Sbjct: 219 PDPEALKVEEIEIPVQVNGKLRARVKVPADADEETVKNIVLSDERVQKWVQGKEVKKFIY 278 Query: 815 VKGRIVNIVV 824 VKG++VN+VV Sbjct: 279 VKGKLVNVVV 288gb|AAD36880.1|AE001819_3 (AE001819) valyl-tRNA synthetase [Thermotoga maritima] Length = 865 Score = 249 bits (628), Expect = 9e-65 Identities = 210/872 (24%), Positives = 365/872 (41%), Gaps = 235/872 (26%) Query: 23 FYTPQRSEKPKYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFG 82 ++TP + K+ ++ P +G +H+GH N + DIV RYKRM+GY+VL G D G Sbjct: 26 YFTP-KGVGEKFSIVIPPPNITGRIHMGHALNITLQDIVVRYKRMKGYDVLWVPGEDHAG 84 Query: 83 LPAENAAIEKGIHPE-----------------EWTRKNIATIRQQVKKLGISYDWSREIA 125 + +NA + + + EW K IR+Q+K LG S DW+RE Sbjct: 85 IATQNAVEKFLLQTQGKTREEIGREKFLEITWEWANKYRREIREQIKALGASVDWTRERF 144 Query: 126 TCDEEYYKWTQWIFLQLYKNGLAYKKKAAVNWCPKCKTVLANEQVKDGKCERCGTSVTIR 185 T DE + + +F++LY+ GL Y+ K VNWCP+CKTVL++E+V+ Sbjct: 145 TLDEGLSRAVRKVFVELYRKGLIYRGKYIVNWCPRCKTVLSDEEVEH------------- 191 Query: 186 HLEQWFFKITDYAERLLNDLDKLTGWPEHVKTMQRNWIGKSTGAEIDFPVEGSDTKIRVF 245 EH KS + +PV+ SD I V Sbjct: 192 --------------------------KEH----------KSKLYYVKYPVKDSDEYIVVA 215 Query: 246 TTRPDTLWGVTFMXXXXXXXXXXXXXXXXXXXXXXXXXXRVKQQDRFRRTSVEAEKEGFF 305 TTRP+T+ G T + + +R++ F Sbjct: 216 TTRPETMLGDTAVAVH-------------------------PEDERYKN----------F 240 Query: 306 LGRYAINPVTGERIPIYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPIKVVIKPAD 365 +G+ I P+ G IP+ Y+ ++GTGA+ PAHD D+ A+++ +P+ + Sbjct: 241 VGKTLILPLVGREIPVVADKYVDPKFGTGAVKVTPAHDPNDYLIAQRHNLPMIEIFD--- 297 Query: 366 KDLDPEKMEEAYEGEGIMVNSGPFDGTPSSEGIEKVINWLEEKG---------------- 409 D ++ E N G + G E EK++ LEE+G Sbjct: 298 ---DNARINE---------NGGKYKGLDRYEAREKIVKDLEEQGFLVKIEDYTHSVGHCY 345 Query: 410 --------------------IGKRSVQ----------------------YKLRDWLISRQ 427 + KR+++ Y++RDW ISRQ Sbjct: 346 RCDTVIEPKLSDQWFVSTKPLAKRAIEAVENGEIRFFPERWTKVYLNWMYEIRDWCISRQ 405 Query: 428 RYWGAPIPIIYCEKCGVVPVPEEDLPVRLPKDVEFLPTGQSPLSFHEGFKKTKCPVCGG- 486 +WG IP+ YC+ CG + V EED+ KC CG Sbjct: 406 LWWGHRIPVWYCQDCGHLNVSEEDVE--------------------------KCEKCGST 439 Query: 487 EAQRETDTMDTFVDSS-WYFLRYVNPHLEDKPFEPDDVNYWLPVDQYIGGVEHAVLHLLY 545 +++ D +DT+ S+ W F P E +D+ + P D + G + +++ Sbjct: 440 NLKQDEDVLDTWFSSALWPFSTLGWPE------ETEDLKRYYPTDLLVTGFD-----IIF 488 Query: 546 SRFVTKVLHDLGYLNFDEPFTNLFTQGMIY-KDGAKMSKSKGNVVSPDEMIEKYGADTLR 604 ++ ++N D+PF++++ ++ K G KMSKS GN + P E+I++YGAD +R Sbjct: 489 FWVARMIMMGYEFMN-DKPFSHVYIHQLVRDKYGRKMSKSLGNGIDPLEVIDEYGADPMR 547 Query: 605 MYILFMAPPEKDAEWSDAGIEGVHRFVKRLWNTFYTVLPFVKEENTENLVLKNSTEKELR 664 + +A +D + + +F ++WN VL +++ L + +K + Sbjct: 548 FTLAILAAQGRDIKLDPRYFDAYKKFANKIWNATRFVLMNLEDYKEVPLENLKTVDKWIL 607 Query: 665 RKLHSIIKKITEDIEGGFKFNTAISGLMELV--NHLSQYLNS----VPQEEWN--RKLLR 716 +L+ ++++T +E + FN A + + Y+ + + EE N + +L Sbjct: 608 TRLNKTVEEVTNALE-NYDFNIAARTIYNFFWDDFCDWYIEASKPRLKTEERNLVQTVLV 666 Query: 717 EIVEKLTLALSPFAPHLAEEFWHDL--GNDSLVVQQSWPSYDPKALEVEEVEIAIQINGK 774 ++++ L PF P L EE W L +S+ + + WP + + ++ + ++ Sbjct: 667 KVLDASLRLLHPFMPFLTEELWQKLPVAGESITIAK-WPEIERELIDETAEKEFTRLMNM 725 Query: 775 VRDKVVVPVDISEEDLKRIVLERERVKEYVDG 806 VR V +++ + + +RVK Y+ G Sbjct: 726 VRGVRNVRAEMN-------LPQSQRVKVYIKG 750sp|O26861|SYV_METTH VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) (VALRS) >gi|2621857 (AE000855) valyl-tRNA synthetase [Methanobacterium thermoautotrophicum] Length = 897 Score = 244 bits (617), Expect = 2e-63 Identities = 207/818 (25%), Positives = 358/818 (43%), Gaps = 191/818 (23%) Query: 31 KPKYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAENAAI 90 KP+Y PYP+G++H+GHV N+V DI+AR+KRMRG++VL P G+D GLP E Sbjct: 56 KPRYIIDTPPPYPTGSIHMGHVLNWVYMDIIARFKRMRGFDVLFPQGWDCHGLPTEVKVE 115 Query: 91 E------KGIHPEEW-------TRKNIATIRQQVKKLGISYDWSREIATCDEEYYKWTQW 137 E + EE+ T++NI +++Q+++LG S DW+ E T EY + TQ Sbjct: 116 ETHNIKKSDVSREEFRRLCVELTQENIRMMKEQMQRLGFSQDWNHEFVTMTPEYMRRTQL 175 Query: 138 IFLQLYKNGLAYKKKAAVNWCPKCKTVLANEQVKDGKCERCGTSVTIRHLEQWFFKITDY 197 FL++Y++GL Y+ VNWCP+C+T +A F +Y Sbjct: 176 SFLRMYRDGLIYQGVHPVNWCPRCETAIA-------------------------FAEVEY 210 Query: 198 AERLLNDLDKLTGWPEHVKTMQRNWIGKSTGAEIDFPVEGSDTKIRVFTTRPDTLWGVTF 257 E N N+ + FPVEG+D I + TTRP+ + Sbjct: 211 IENETN----------------LNY--------VRFPVEGADEHITIATTRPELMAACVA 246 Query: 258 MXXXXXXXXXXXXXXXXXXXXXXXXXXRVKQQDRFRRTSVEAEKEGFFLGRYAINPVTGE 317 + +RFR F + P+ G+ Sbjct: 247 VVVH-------------------------PDDERFRE----------FEDKLIEVPLFGQ 271 Query: 318 RIPIYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPIKVVIKPADKDLD-------- 369 ++ + + E+GTGA+M D+ D S+ ++G+ + I + Sbjct: 272 KVKLIKDPEVDPEFGTGAVMVCTFGDKTDVSWVNRHGLDVIDAIDERGYMTEAAGKYQGL 331 Query: 370 -----PEKMEEAYEGEGIMVNSGPFDGTPSS-----------------EGIEKVINWLEE 407 EK+ E E EG ++ P + ++K+I + E Sbjct: 332 TIAECKEKIVEDLENEGFLLKKEPVRQNVGTCWRCKTPIEILVKKQWFVAVKKLIPQVRE 391 Query: 408 KGIGKRSVQYKLR------------DWLISRQRYWGAPIPIIYCEKCGVVPVPEEDLPVR 455 + V ++ DW ISRQR + PIP+ YC +CG V V +E++ Sbjct: 392 AAEEMKWVPGHMKTRLLNWTGSMDWDWCISRQRIFATPIPVWYCSECGRVHVADEEM--- 448 Query: 456 LPKDVEFLPTGQSPLSFHEGFKKTKCPVCGGEAQRETDTMDTFVDSSWYFLRYVNPHLED 515 LP D PT P C E E D +DT++DSS ++P L Sbjct: 449 LPVD----PTRDGP--------GITCECGSTEFIGEEDVLDTWMDSS------ISP-LSV 489 Query: 516 KPFEPDDVNYWLPVDQYIGGVEHAVLHLLYSRFVTKVLHDLGYLNFDEPFTNLFTQGMIY 575 + + P D G H ++ + + + L ++PF+ + GM++ Sbjct: 490 AGWPDESYRELFPADLRPQG--HDIIRTWAFYTILRCM----ALTGEKPFSEIVINGMVF 543 Query: 576 -KDGAKMSKSKGNVVSPDEMIEKYGADTLRMYILFMAPPEKDAEWSDAGIEGVHRFVKRL 634 +DG KMSKS+GNV++P+E++E YGAD LR++ + P D ++ ++ ++F+++ Sbjct: 544 GEDGHKMSKSRGNVIAPEEVLEDYGADALRLWAA-GSVPGSDVPFAWKDVKYGYKFLRKF 602 Query: 635 WNTFYTVLPFVKEENTEN-LVLKNSTEKELRRKLHSIIKKITEDIEGGFKFNTAISGLME 693 WN F F+ TEN V ++ + +L +++ ++TE ++ + F A++ + Sbjct: 603 WNAF----RFISIHLTENPEVEARPMDRWILSRLMNLVAEVTESLD-DYNFAAAVNRVQT 657 Query: 694 LVNH--LSQYLNSVPQEEWN----------RKLLREIVEKLTLALSPFAPHLAEEFWHDL 741 + H +Y+ +V ++ + LR +++ L+P APH EE + Sbjct: 658 FIWHDFCDEYIEAVKYRLYSDEDPESRMAAQNTLRMVLDTCLRLLAPVAPHFTEEVHQHV 717 Query: 742 GNDSLVVQQSWPSYDPKALEVE---EVEIAIQINGKVR 776 G S+ + + WP + P+ ++ E ++A++I G++R Sbjct: 718 GEGSIHL-RGWPEHIPEIVDPEIERSGDLAVEIIGEIR 754sp|Q58413|SYV_METJA VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) (VALRS) >gi|2129352|pir||F64425 valine--tRNA ligase (EC 6.1.1.9) - Methanococcus jannaschii >gi|1591666 (U67543) valyl-tRNA synthetase (valS) [Methanococcus jannaschii] Length = 878 Score = 230 bits (580), Expect = 4e-59 Identities = 218/818 (26%), Positives = 333/818 (40%), Gaps = 207/818 (25%) Query: 27 QRSEKPKYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAE 86 + S KP Y PYP+G LH+GH N+ DI+ARYKRM+G+NVL P G+D GLP E Sbjct: 29 EESNKPPYIIDTPPPYPTGRLHLGHALNWTYMDIIARYKRMKGFNVLFPQGWDCHGLPTE 88 Query: 87 NAAIE-KGIHPE------------EWTRKNIATIRQQVKKLGISYDWSREIATCDEEYYK 133 E GI E T++NI +R+Q+K LGIS DW +E T EY K Sbjct: 89 VKVEEIHGITKSDVDRHKFRELCIELTKENIEKMRRQIKSLGISIDWDKEYITMTPEYIK 148 Query: 134 WTQWIFLQLYKNGLAYKKKAAVNWCPKCKTVLANEQVKDGKCERCGTSVTIRHLEQWFFK 193 +Q F+++YK+GL Y+ K VNWCP RC T++ +E Sbjct: 149 KSQTAFVRMYKDGLIYRGKFPVNWCP-----------------RCQTAIAFAEVE----- 186 Query: 194 ITDYAERLLNDLDKLTGWPEHVKTMQRNWIGKSTGAEIDFPVEGSDTKIRVFTTRPDTLW 253 Y ER +S I FP + + + TTRP+ + Sbjct: 187 ---YKER------------------------ESKLNYIKFPAADGEGHLLIATTRPELMA 219 Query: 254 GVTFMXXXXXXXXXXXXXXXXXXXXXXXXXXRVKQQDRFRRTSVEAEKEGFFLGRYAINP 313 + E E+ +G+ I P Sbjct: 220 ACVAIL-----------------------------------VHPEDERYKHLIGKEFIVP 244 Query: 314 VTGERIPIYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPIKVVI------------ 361 + G ++ + + E+GTGA+M D+ D + ++ + IK I Sbjct: 245 LFGHKVKLLADEDVEKEFGTGAVMVCTFGDKTDVLWVNRHKLEIKKAIDEKGELTEIAGK 304 Query: 362 -KPADKDLDPEKMEEAYEGEGIMVNSGPFDGT---------------------------P 393 K + EK+ E + EG +V P P Sbjct: 305 YKGLKTEEAREKIIEDLKKEGYLVKQEPIKQNVGVCWRCKTPIEIIVTEQWFVNVRKLIP 364 Query: 394 SSEGIEKVINWLEEKGIGKRSVQYKLR----------DWLISRQRYWGAPIPIIYCEKCG 443 + I W+ E K+R DW+ISRQR + PIP+ YC KCG Sbjct: 365 KVREVADEIKWIPE--------HMKIRLLNWIEDMDWDWVISRQRIFATPIPVWYCPKCG 416 Query: 444 -VVPVPEEDLPVRLPKDVEFLPTGQSPLSFHEGFKKTKCPVCGG-EAQRETDTMDTFVDS 501 VV EEDLP+ K TG C CG + ETD +DT++DS Sbjct: 417 NVVVAKEEDLPIDPTK------TGYV------------CDKCGNKDLIPETDVLDTWMDS 458 Query: 502 SWYFLRYVNPHLEDKPFEPDDVNYWLPVDQYIGGVEHAVLHLLYSRFVTKVLHDLGYLNF 561 S + +DK FE PV G H ++ + K + G + Sbjct: 459 SITPMVITKWLDDDKFFEKH-----YPVQLRPQG--HDIIRTWAFYTIVKSVALTGKKPW 511 Query: 562 DEPFTNLFTQGMIY-KDGAKMSKSKGNVVSPDEMIEKYGADTLRMYILFMAPPEKDAEWS 620 DE N GM++ +DG KMSKS+GNVV PDE+I KYGAD LR++ + D ++ Sbjct: 512 DEIVIN----GMVFGEDGHKMSKSRGNVVEPDEIIAKYGADALRLWASNSVVGD-DVQFL 566 Query: 621 DAGIEGVHRFVKRLWNTFYTVLPFVKEENTENL----VLKNSTEKELRRKLHSIIKKITE 676 ++ +RF+++ WN + ++ + L + N + + KL +I+++ + Sbjct: 567 WKEVDYGYRFLRKSWNACRFAKMHISDDIIDELKKPMEISNPIDLWILSKLQRLIERVDK 626 Query: 677 DIEGGFKFNTAI-----------SGLMELVNHLSQYLNSVPQEEWNRKLLREIVEKLTLA 725 D+E ++FNT + +E+V + Y + ++ R L +++K+ Sbjct: 627 DLE-NYRFNTIVEIYKFVWHEFCDNYIEMVKY-RLYGDDEEAKKEARWTLYYVIDKVVRL 684 Query: 726 LSPFAPHLAEEFWHDLGNDSLVVQQSWPSYDPKALEVE 763 L PFAPH ++ D+L S+P D + + E Sbjct: 685 LCPFAPHFSDYIAEIYKIDNL--HFSFPEVDNRFINEE 720sp|O30250|SYL_ARCFU LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS) >gi|2650668 (AE001108) leucyl-tRNA synthetase (leuS) [Archaeoglobus fulgidus] Length = 932 Score = 205 bits (515), Expect = 2e-51 Identities = 210/858 (24%), Positives = 330/858 (37%), Gaps = 179/858 (20%) Query: 29 SEKPKYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLP---- 84 +EK K++ + +PY +G LH GH + + IGD ARY RM+GYNVL P G+ G P Sbjct: 26 NEKEKFFLTIPYPYLNGNLHAGHTRTFTIGDAFARYMRMKGYNVLFPLGFHVTGTPIIGL 85 Query: 85 AENAAIEKGIHPEEWTRKNIATIR--------------------QQVKKLGISYDWSREI 124 AE A E +T+ + + Q +K +G S DW R Sbjct: 86 AELIAKRDERTIEVYTKYHDVPLEDLLQLTTPEKIVEYFSREALQALKSIGYSIDWRRVF 145 Query: 125 ATCDEEYYKWTQWIFLQLYKNGLAYKKKAAVNWCPKCKTVLANEQVKDGKCERCGTSVTI 184 T DEEY ++ +W + +L + GL K V +CP Sbjct: 146 TTTDEEYQRFIEWQYWKLKELGLIVKGTHPVRYCP------------------------- 180 Query: 185 RHLEQWFFKITDYAERLLNDLDKLTGWPEHVKTMQRNWIGKSTGAEIDFPVEGSDTKIRV 244 + + + D D L G + I F +E D Sbjct: 181 ------------HDQNPVEDHDLLAGEEATIVEF----------TVIKFRLEDGDLIFPC 218 Query: 245 FTTRPDTLWGVTFMXXXXXXXXXXXXXXXXXXXXXXXXXXRVKQQDRFRRTSVEAEKEGF 304 T RP+T++GVT + + + R E + F Sbjct: 219 ATLRPETVFGVTNIWVKPTTYVIAEVDGEKWFVSKEAYEKLTYTEKKVRLLE-EVDASQF 277 Query: 305 FLGRYAINPVTGERIPIYVANYILMEYGTGAIMGVPAHD----------QRDFSFAKKYG 354 F G+Y I P+ ++PI A ++ + TG +M VPAH +RD KYG Sbjct: 278 F-GKYVIVPLVNRKVPILPAEFVDTDNATGVVMSVPAHAPFDLAAIEDLKRDEETLAKYG 336 Query: 355 IPIKVV--IKPA-------------------------DKDLDPEKMEEAYEGE---GIMV 384 I VV IKP DK+L + + Y+ E GIM+ Sbjct: 337 IDKSVVESIKPIVLIKTDIEGVPAEKLIRELGVKSQKDKELLDKATKTLYKKEYHTGIML 396 Query: 385 -NSGPFDGTPSSEGIEKVINWLEEKGIGKRSVQYK----------------LRD-WLIS- 425 N+ + G SE E+V L + G+G ++ +RD W ++ Sbjct: 397 DNTMNYAGMKVSEAKERVHEDLVKLGLGDVFYEFSEKPVICRCGTKCVVKVVRDQWFLNY 456 Query: 426 RQRYWGAPIPIIYCEKCGVVP-------------------VPEEDLPVRLPKDVEFLPTG 466 R W + + + EK ++P + L R+P D E+L Sbjct: 457 SNREWKEKV-LNHLEKMRIIPDYYKEEFRNKIEWLRDKACARRKGLGTRIPWDKEWLIES 515 Query: 467 QSPLSFHEGFKKTKCPVCGGEAQRETDTMDTFVDSSWYFLRYVNPHLEDKPFEP------ 520 S + + + + G + E T + F+D V E Sbjct: 516 LSDSTIYMAYYILAKYINAGLLKAENMTPE-FLDYVLLGKGEVGKVAEASKLSVELIQQI 574 Query: 521 -DDVNYWLPVDQYIGGVEHAVLHLLYSRFVTKVLHDLGYLNFDEPFTNLFTQGMIYKDGA 579 DD YW PVD G + HLL+ F H + D+ + G + +G Sbjct: 575 RDDFEYWYPVDLRSSGKDLVANHLLFYLF-----HHVAIFPPDKWPRAIAVNGYVSLEGK 629 Query: 580 KMSKSKGNVVSPDEMIEKYGADTLRMYILFMAPPEKDAEWSDAGIEGVHRFVKRLWNTFY 639 KMSKSKG +++ +++YGAD R+YIL A + DA+W +EG+ ++R +N Sbjct: 630 KMSKSKGPLLTMKRAVQQYGADVTRLYILHAAEYDSDADWKSREVEGLANHLRRFYN--- 686 Query: 640 TVLPFVKEENTENLVLKNSTEKELRRKLHSIIKKITEDIEGGFKFNTAISGLMELVNHLS 699 VKE + + + ++ L ++ IK++ E ++ + EL+N + Sbjct: 687 ----LVKENYLKEVGELTTLDRWLVSRMQRAIKEVREAMDNLQTRRAVNAAFFELMNDVR 742 Query: 700 QYLNSVPQEEWNRKLLREIVEKLTLALSPFAPHLAEEFWHDLGNDSLVVQQSWPSYDPKA 759 YL + L I++ L+PFAPH+ EE WH L +DS V +S+P YD Sbjct: 743 WYLRRGGEN------LAIILDDWIKLLAPFAPHICEELWH-LKHDSYVSLESYPEYDETR 795 Query: 760 LEVEEVEIAIQINGKVRD 777 ++ E I + V D Sbjct: 796 VDEEAERIEEYLRNLVED 813sp|O27428|SYI_METTH ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA LIGASE) (ILERS) >gi|2622484 (AE000900) isoleucyl-tRNA synthetase [Methanobacterium thermoautotrophicum] Length = 1044 Score = 201 bits (505), Expect = 2e-50 Identities = 206/896 (22%), Positives = 345/896 (37%), Gaps = 207/896 (23%) Query: 28 RSEKPKYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAEN 87 R ++P+Y L PY SG +H+G N ++ D R+K M+G+NV G+D GLP E+ Sbjct: 36 REDRPRYSFLDGPPYCSGRIHLGTAWNKIMKDTYLRFKSMKGFNVRRQPGWDTHGLPIEH 95 Query: 88 AA-----------IEKGIHPEEWTRK-------NIATIRQQVKKLGISYDWSREIATCDE 129 IE I EE+ K N A + Q ++LG+ DW T D Sbjct: 96 KVEGLLGVRSKKDIEDKIGIEEFVNKCREFAVENKAVMTGQFQRLGVWMDWDDPYVTFDP 155 Query: 130 EYYKWTQWIFLQLYKNGLAYKKKAAVNWCPKCKTVLANEQVKDGKCERCGTSVTIRHLEQ 189 Y + W + ++ L + + WCP+C+T LA ++ Sbjct: 156 AYMESCWWTLKRAHEKDLLVRDLRVITWCPRCETALALAEI------------------- 196 Query: 190 WFFKITDYAERLLNDLDKLTGWPEHVKTMQRNWIGKSTGAEIDFPVEGSDTKIRVFTTRP 249 DY ++ + + FPV G DT I V+TT P Sbjct: 197 ------DYHDK------------------------EDPSIYVKFPVSG-DTHILVWTTTP 225 Query: 250 DTLWGVTFMXXXXXXXXXXXXXXXXXXXXXXXXXXRVKQQDRFRRTSVEAEKEGFFLGRY 309 TL + +V ++ V+ + R+ Sbjct: 226 WTLPANMAVAVHPDFEYAYARLDGETYIMAEALVEKVLGEEAEILKRVKGTELEGLTYRH 285 Query: 310 AINPVTGERIPIY--------VANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPIKVVI 361 ++ + +P++ + +++ + GTG + P H DF KKYG+ + + Sbjct: 286 PLD----DEVPLHREIEHRVILGDHVTLTEGTGCVHTAPGHGPEDFEIGKKYGLEVICPV 341 Query: 362 KPAD--------------KDLDPEKMEEAYEGEGIMVNSGPFDG---------------- 391 A KD D + + + +G+++ +G Sbjct: 342 DEAGIFTEEAGKYSGRFVKDADEDIIADL-RSKGLLLKAGTISHRYGFCWRCKTPIIYLA 400 Query: 392 ------------------------TPSSEGIEKVINWLEEKGIGKRSVQYKLRDWLISRQ 427 PS G + NW+E RDW ISRQ Sbjct: 401 TEQWFLKITEIKDKMLRELDRVQWVPSWAGESRFRNWIENA-----------RDWTISRQ 449 Query: 428 RYWGAPIPIIYCEKCGVVPVPEEDLPVRLPKDVEFLPTGQSPLSF----HEGFKKTKCPV 483 RYWG PIPI CE+C + V +R E G+ F H +C Sbjct: 450 RYWGIPIPIWICEECDSIHVVGSIDELR-----ELAVEGELEGDFIHRPHVDRIVLECGE 504 Query: 484 CGGEAQRETDTMDTFVDSS---WYFLRYVNPHLEDKPFEPDDVNYWLPVDQYIGGVEHAV 540 CGG +R D +D ++DS W L Y P E + W P D G + Sbjct: 505 CGGRMKRTPDVLDVWIDSGVAGWAALHY--------PSETELFREWFPYDFITEGHDQT- 555 Query: 541 LHLLYSRFVTKVLHDLGYLNFDE-PFTNLFTQGM-IYKDGAKMSKSKGNVVSPDEMIEKY 598 YS+ G + DE P+ + G + ++G KMSKS GNVV P+++IEKY Sbjct: 556 RGWFYSQL------GCGVIALDEVPYRRVLMHGFTLDEEGRKMSKSLGNVVEPEDVIEKY 609 Query: 599 GADTLRMYILFMAPPEKDAEWSDAGIEGVHRFVKRLWNTFYTVLPFVK-------EENTE 651 GAD LR Y+L+ P +D ++ + V++ LWN + ++ + + E Sbjct: 610 GADVLRFYLLWENKPWEDLKFVWDELRNVNKMFNILWNVYVFATTYMSLDRFQPGDHSAE 669 Query: 652 NLVLKNSTEKELRRKLHSIIKKITEDIEGGFKFNTAISGLME-LVNHLSQ-YLNSVPQEE 709 +L ++ ++ + +++S+ K+TE IE F+ A + + +V LS+ Y+ + Sbjct: 670 DLSFRDE-DRWILSRINSVALKVTEAIE-NLHFHRATREIHDFIVEDLSRWYIRLIRSRT 727 Query: 710 WNRK----------LLREIVEKLTLALSPFAPHLAEEFWHDLGNDSLVVQQSWPSYDPKA 759 W + L +++ L + LSP APH+ E+ + +L + +P + Sbjct: 728 WIERDDPDKLAAYHTLYTVLKTLIVTLSPMAPHVCEDIYQNLVRGA----------EPDS 777 Query: 760 LEVEEVEIAIQINGKVRDKVVVPVDISEEDLKRIVLERERVKEYVDGKPIRKFIYV 815 E + I G V ++ +DI E ++ R+ + Y P+R+ + V Sbjct: 778 PESIHMLDWILDEGAVDSQLEADMDIVREIIEACARARDTAR-YKLRWPVREMVVV 832sp|P26499|SYI_METTM ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA LIGASE) (ILERS) Length = 1046 Score = 198 bits (499), Expect = 1e-49 Identities = 200/811 (24%), Positives = 318/811 (38%), Gaps = 174/811 (21%) Query: 28 RSEKPKYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAEN 87 R E P+Y L PY SG +H+G N ++ D R+K MRG+NV G+D GLP E+ Sbjct: 37 REEGPRYSFLDGPPYCSGRIHLGTAWNKIMKDSYLRFKSMRGFNVRRQPGWDTHGLPIEH 96 Query: 88 AA-----------IEKGIHPEEWTRK-------NIATIRQQVKKLGISYDWSREIATCDE 129 IE I EE+ RK N A + Q ++LG+ DW T D Sbjct: 97 KVEGILGVRSKKDIEDKIGIEEFVRKCREFAMENKAVMTSQFQRLGVWMDWDDPYVTFDP 156 Query: 130 EYYKWTQWIFLQLYKNGLAYKKKAAVNWCPKCKTVLANEQVKDGKCERCGTSVTIRHLEQ 189 Y + W + ++ L + + WCP+C+T LA ++ Sbjct: 157 AYMESCWWTLKRAHEKDLLLRDLRVITWCPRCETALALAEI------------------- 197 Query: 190 WFFKITDYAERLLNDLDKLTGWPEHVKTMQRNWIGKSTGAEIDFPVEGSDTKIRVFTTRP 249 DY E+ + + FPV G DT I V+TT P Sbjct: 198 ------DYHEK------------------------EDPSIYVKFPVSG-DTYILVWTTTP 226 Query: 250 DTLWGVTFMXXXXXXXXXXXXXXXXXXXXXXXXXXRV-KQQDRFRRTSVEAEKEGFFLGR 308 TL + +V ++ +T +E EG R Sbjct: 227 WTLPANMAVAVHPDFDYAHTRLDGETYIMAEALVEKVLGEEAEIIKTVRGSELEGLTY-R 285 Query: 309 YAINPVTGERIP--------IYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPI--- 357 + ++ E +P + + +++ + GTG + P H DF K+YG+P+ Sbjct: 286 HPLD----EEVPCHRDMEHRVILGDHVTLTEGTGCVHTAPGHGPEDFEIGKEYGLPVFCP 341 Query: 358 ---------------KVVIKPADKDL--DPEKMEEAYEGEGIMVNSG-------PFDGTP 393 + +K AD D+ D E I G P Sbjct: 342 VDEAGVFTEDAGKYRGLFVKDADSDIIDDLRSKNLLLRAETISHRYGFCWRCKTPIIYLA 401 Query: 394 SSEGIEKV-------------INWLEEKGIGKRSVQY--KLRDWLISRQRYWGAPIPIIY 438 + + K+ + W+ R + RDW ISRQRYWG PIPI Sbjct: 402 TEQWFLKITEIKDKMLSELDRVQWIPSWAGESRFRNWIENARDWTISRQRYWGIPIPIWV 461 Query: 439 CEKCGVVPVPEEDLPVRLPKDVEFLPTGQSPLSF----HEGFKKTKCPVCGGEAQRETDT 494 CE C + V +R E GQ F H +C CGG +R D Sbjct: 462 CEDCDSIHVVGSIGELR-----ELAVEGQLEGDFIHRPHVDRIILECGRCGGRMKRTPDV 516 Query: 495 MDTFVDS---SWYFLRYVNPHLEDKPFEPDDVNYWLPVDQYIGGVEHAVLHLLYSRFVTK 551 +D ++DS W L Y P E + + W P D +I YS+ Sbjct: 517 LDVWIDSGVAGWAALHY--------PREKELFSEWFPYD-FITEGHDQTRGWFYSQL--- 564 Query: 552 VLHDLGYLNFDE-PFTNLFTQGM-IYKDGAKMSKSKGNVVSPDEMIEKYGADTLRMYILF 609 G + DE P+ + G + ++G KMSKS GNVV P+++IEKYGAD LR Y+L+ Sbjct: 565 ---GCGVIALDETPYRRVLMHGFTLDEEGRKMSKSLGNVVEPEDVIEKYGADVLRFYLLW 621 Query: 610 MAPPEKDAEWSDAGIEGVHRFVKRLWNTFYTVLPFVK-------EENTENLVLKNSTEKE 662 P +D ++ ++ V++ LWN + ++ + E+L ++ ++ Sbjct: 622 ANKPWEDLKFVWDELKNVNKMFNILWNVYVFATTYMSLDRFQPGDHELEDLHFRDE-DRW 680 Query: 663 LRRKLHSIIKKITEDIEGGFKFNTAISGLME-LVNHLSQ-YLNSVPQEEWNRK------- 713 + +++S+ K+TE ++ F+ A + + +V LS+ Y+ + W + Sbjct: 681 IISRVNSVALKVTEALD-NLHFHRATREIHDFIVEDLSRWYIRLIRSRTWIERDDPDKLA 739 Query: 714 ---LLREIVEKLTLALSPFAPHLAEEFWHDL 741 L ++ L + LSP APH+ E+ + +L Sbjct: 740 AYHSLYTALKTLIVTLSPIAPHVCEDIYQNL 770pir||SYEXI isoleucine--tRNA ligase (EC 6.1.1.5) - Methanobacterium thermoautotrophicum >gi|149728 (M59245) transfer RNA-Ile synthetase [Methanobacterium thermoautotrophicum] Length = 1045 Score = 198 bits (499), Expect = 1e-49 Identities = 200/811 (24%), Positives = 318/811 (38%), Gaps = 174/811 (21%) Query: 28 RSEKPKYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAEN 87 R E P+Y L PY SG +H+G N ++ D R+K MRG+NV G+D GLP E+ Sbjct: 36 REEGPRYSFLDGPPYCSGRIHLGTAWNKIMKDSYLRFKSMRGFNVRRQPGWDTHGLPIEH 95 Query: 88 AA-----------IEKGIHPEEWTRK-------NIATIRQQVKKLGISYDWSREIATCDE 129 IE I EE+ RK N A + Q ++LG+ DW T D Sbjct: 96 KVEGILGVRSKKDIEDKIGIEEFVRKCREFAMENKAVMTSQFQRLGVWMDWDDPYVTFDP 155 Query: 130 EYYKWTQWIFLQLYKNGLAYKKKAAVNWCPKCKTVLANEQVKDGKCERCGTSVTIRHLEQ 189 Y + W + ++ L + + WCP+C+T LA ++ Sbjct: 156 AYMESCWWTLKRAHEKDLLLRDLRVITWCPRCETALALAEI------------------- 196 Query: 190 WFFKITDYAERLLNDLDKLTGWPEHVKTMQRNWIGKSTGAEIDFPVEGSDTKIRVFTTRP 249 DY E+ + + FPV G DT I V+TT P Sbjct: 197 ------DYHEK------------------------EDPSIYVKFPVSG-DTYILVWTTTP 225 Query: 250 DTLWGVTFMXXXXXXXXXXXXXXXXXXXXXXXXXXRV-KQQDRFRRTSVEAEKEGFFLGR 308 TL + +V ++ +T +E EG R Sbjct: 226 WTLPANMAVAVHPDFDYAHTRLDGETYIMAEALVEKVLGEEAEIIKTVRGSELEGLTY-R 284 Query: 309 YAINPVTGERIP--------IYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPI--- 357 + ++ E +P + + +++ + GTG + P H DF K+YG+P+ Sbjct: 285 HPLD----EEVPCHRDMEHRVILGDHVTLTEGTGCVHTAPGHGPEDFEIGKEYGLPVFCP 340 Query: 358 ---------------KVVIKPADKDL--DPEKMEEAYEGEGIMVNSG-------PFDGTP 393 + +K AD D+ D E I G P Sbjct: 341 VDEAGVFTEDAGKYRGLFVKDADSDIIDDLRSKNLLLRAETISHRYGFCWRCKTPIIYLA 400 Query: 394 SSEGIEKV-------------INWLEEKGIGKRSVQY--KLRDWLISRQRYWGAPIPIIY 438 + + K+ + W+ R + RDW ISRQRYWG PIPI Sbjct: 401 TEQWFLKITEIKDKMLSELDRVQWIPSWAGESRFRNWIENARDWTISRQRYWGIPIPIWV 460 Query: 439 CEKCGVVPVPEEDLPVRLPKDVEFLPTGQSPLSF----HEGFKKTKCPVCGGEAQRETDT 494 CE C + V +R E GQ F H +C CGG +R D Sbjct: 461 CEDCDSIHVVGSIGELR-----ELAVEGQLEGDFIHRPHVDRIILECGRCGGRMKRTPDV 515 Query: 495 MDTFVDS---SWYFLRYVNPHLEDKPFEPDDVNYWLPVDQYIGGVEHAVLHLLYSRFVTK 551 +D ++DS W L Y P E + + W P D +I YS+ Sbjct: 516 LDVWIDSGVAGWAALHY--------PREKELFSEWFPYD-FITEGHDQTRGWFYSQL--- 563 Query: 552 VLHDLGYLNFDE-PFTNLFTQGM-IYKDGAKMSKSKGNVVSPDEMIEKYGADTLRMYILF 609 G + DE P+ + G + ++G KMSKS GNVV P+++IEKYGAD LR Y+L+ Sbjct: 564 ---GCGVIALDETPYRRVLMHGFTLDEEGRKMSKSLGNVVEPEDVIEKYGADVLRFYLLW 620 Query: 610 MAPPEKDAEWSDAGIEGVHRFVKRLWNTFYTVLPFVK-------EENTENLVLKNSTEKE 662 P +D ++ ++ V++ LWN + ++ + E+L ++ ++ Sbjct: 621 ANKPWEDLKFVWDELKNVNKMFNILWNVYVFATTYMSLDRFQPGDHELEDLHFRDE-DRW 679 Query: 663 LRRKLHSIIKKITEDIEGGFKFNTAISGLME-LVNHLSQ-YLNSVPQEEWNRK------- 713 + +++S+ K+TE ++ F+ A + + +V LS+ Y+ + W + Sbjct: 680 IISRVNSVALKVTEALD-NLHFHRATREIHDFIVEDLSRWYIRLIRSRTWIERDDPDKLA 738 Query: 714 ---LLREIVEKLTLALSPFAPHLAEEFWHDL 741 L ++ L + LSP APH+ E+ + +L Sbjct: 739 AYHSLYTALKTLIVTLSPIAPHVCEDIYQNL 769sp|Q05873|SYV_BACSU VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) (VALRS) >gi|541424|pir||S41420 valine--tRNA ligase (EC 6.1.1.9) - Bacillus subtilis >gi|452309|emb|CAA54458| (X77239) valyl-tRNA synthetase [Bacillus subtilis] >gi|2635274|emb|CAB14769| (Z99118) valyl-tRNA synthetase [Bacillus subtilis] Length = 880 Score = 185 bits (465), Expect = 1e-45 Identities = 194/830 (23%), Positives = 331/830 (39%), Gaps = 212/830 (25%) Query: 31 KPKYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAENAAI 90 K Y ++ P +G LH+GH + + DIV R KRM+GY+VL G D G+ A A + Sbjct: 39 KEPYSVVIPPPNVTGRLHLGHAWDTTLQDIVTRMKRMQGYDVLWLPGMDHAGI-ATQAKV 97 Query: 91 EKGIHPE-----------------EWTRKNIATIRQQVKKLGISYDWSREIATCDEEYYK 133 E + E +W + IR Q KLG+ D+SRE T DE K Sbjct: 98 EAKLREEGKSRYDLGREKFLEETWKWKEEYADFIRSQWAKLGLGLDYSRERFTLDEGLSK 157 Query: 134 WTQWIFLQLYKNGLAYKKKAAVNWCPKCKTVLANEQVKDGKCERCGTSVTIRHLEQWFFK 193 + +F++LY+ GL Y+ + +NW P KT L++ + V + ++ F+ Sbjct: 158 AVREVFVKLYEKGLIYRGEYIINWDPATKTALSDIE------------VIYKDVQGAFYH 205 Query: 194 ITDYAERLLNDLDKLTGWPEHVKTMQRNWIGKSTGAEIDFPVEGSDTKIRVFTTRPDTLW 253 ++ +P+ I + TTRP+T+ Sbjct: 206 MS-------------------------------------YPLADGSGSIEIATTRPETML 228 Query: 254 GVTFMXXXXXXXXXXXXXXXXXXXXXXXXXXRVKQQDRFRRTSVEAEKEGFFLGRYAINP 313 G T + E E+ +G+ I P Sbjct: 229 GDTAVA-----------------------------------VHPEDERYKHLIGKTVILP 253 Query: 314 VTGERIPIYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPIKVVI------------ 361 + IPI +Y+ ME+G+GA+ PAHD DF ++ + +V+ Sbjct: 254 IVNREIPIVGDDYVDMEFGSGAVKITPAHDPNDFELGNRHNLERILVMNEDGTMNENALQ 313 Query: 362 ----------KPADKDLDPE----KMEEAYEGEGIMVNSG----PF-------------D 390 K KDL K+E+ G SG P+ D Sbjct: 314 YQGMDRFECRKKLVKDLQEAGVLFKIEDHMHSVGHSERSGAVVEPYLSTQWFVRMQPLAD 373 Query: 391 GTPSSEGIEKVINWLEEKGIGKRSVQY--KLRDWLISRQRYWGAPIPIIYCEKCGVVPVP 448 E E+ +N++ ++ K + + +RDW ISRQ +WG IP Y ++ G + V Sbjct: 374 AAIELEKKEEKVNFVPDR-FEKTYLHWMENIRDWCISRQLWWGHRIPAWYHKETGELYVG 432 Query: 449 EEDLPVRLPKDVEFLPTGQSPLSFHEGFKKTKCPVCGGEAQRETDTMDTFVDSS-WYFLR 507 E P+D E +++TD +DT+ S+ W F Sbjct: 433 LE-----APEDSE-------------------------NWEQDTDVLDTWFSSALWPFST 462 Query: 508 YVNPHLEDKPFEPDDVNYWLPVDQYIGGVEHAVLHLLYSRFVTKVLHDLGYLNFDEPFTN 567 P + +D + P D + G + ++ SR + + + G + PF + Sbjct: 463 MGWPDVT-----AEDFKRYYPTDVLVTGYD--IIFFWVSRMIFQGIEFTG----ERPFKD 511 Query: 568 LFTQGMIYKD-GAKMSKSKGNVVSPDEMIEKYGADTLRMYILFMAPPEKDAEWSDAGIEG 626 + G+I + G KMSKS GN V P ++I+KYGAD+LR ++ + P +D +S +E Sbjct: 512 VLIHGLIRDEQGRKMSKSLGNGVDPMDVIDKYGADSLRYFLATGSSPGQDLRFSYEKVES 571 Query: 627 VHRFVKRLWNTFYTVLPFVKEENTENLVL---KNSTEKELRRKLHSIIKKITEDIEGGFK 683 F ++WN L + + L L K+ +K + +L+ I+ +T+ + ++ Sbjct: 572 TWNFANKIWNASRFALMNMDGMTYDELDLSGEKSVADKWILTRLNETIEHVTQ-LADRYE 630 Query: 684 FNTAISGLMELV-----------NHLSQYLNSVPQEEWNRKLLREIVEKLTLALSPFAPH 732 F L + L Y ++ R +L ++++ L PF P Sbjct: 631 FGEVGRHLYNFIWDDFCDWYIEMAKLPLYGEDEAAKKTTRSILAYVLDQTMRLLHPFMPF 690 Query: 733 LAEEFWHDLGN--DSLVVQQSWPSYDPKALEVE---EVEIAIQINGKVRD 777 L EE W L + +S+ V Q WP+ P+ + E ++++ +++ VR+ Sbjct: 691 LTEEIWQHLPHQGESITVSQ-WPAVVPEHTDTEAAADMKLLVELIRSVRN 739sp|P96142|SYV_THETH VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) (VALRS) >gi|1814011|emb|CAA71837| (Y10900) valyl-tRNA synthetase [Thermus thermophilus] Length = 854 Score = 183 bits (461), Expect = 4e-45 Identities = 205/824 (24%), Positives = 318/824 (37%), Gaps = 209/824 (25%) Query: 23 FYTPQRSEKPKYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFG 82 F +S KP + + P +G+LH+GH + + D + RYKRMRG+ + G D G Sbjct: 25 FVANPKSGKPPFVIFMPPPNVTGSLHMGHALDNSLQDALIRYKRMRGFEAVWLPGTDHAG 84 Query: 83 LPAENAAIEKGIHPE-----------------EWTRKNIATIRQQVKKLGISYDWSREIA 125 + A +E+ + E +W ++ TI +Q+K+LG S DWSRE Sbjct: 85 I-ATQVVVERLLLKEGKTRHDLGREKFLERVWQWKEESGGTILKQLKRLGASADWSREAF 143 Query: 126 TCDEEYYKWTQWIFLQLYKNGLAYKKKAAVNWCPKCKTVLANEQVKDGKCERCGTSVTIR 185 T DE + F + Y GLAY+ VNW C RC T+ Sbjct: 144 TMDENAPA-VPYAFSRYYHEGLAYRAPRLVNW-----------------CPRCETT---- 181 Query: 186 HLEQWFFKITDYAERLLNDLDKLTG-WPEHVKTMQRNWIGKSTGAEIDFPVEGSDTKIRV 244 L+DL+ T P + T++ + VEG I + Sbjct: 182 ----------------LSDLEVETEPTPGKLYTLR-------------YEVEGGGF-IEI 211 Query: 245 FTTRPDTLWGVTFMXXXXXXXXXXXXXXXXXXXXXXXXXXRVKQQDRFRRTSVEAEKEGF 304 T RP+T++ D+ E E+ Sbjct: 212 ATVRPETVFA-----------------------------------DQAIAVHPEDERYRH 236 Query: 305 FLGRYAINPVTGERIPIYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGI-PIKVV--- 360 LG+ A RIPI + ++GTGA+ PAHD D+ +++G+ P+ V+ Sbjct: 237 LLGKRA-------RIPILADPAVEKDFGTGALKVTPAHDPLDYEIGERHGLKPVSVINLE 289 Query: 361 -----------IKPADKDLDPEKMEEAYEGEGIMVNSGPFD---------GTPSSEGI-- 398 ++ D+ K E + G +V + GTP I Sbjct: 290 GRMEGERVPEALRGLDRFEARRKAVELFREAGHLVKEEDYTIALATCSRCGTPIEYAIFP 349 Query: 399 ----------EKVINWLEEKGIGKRSVQYK---------LRDWLISRQRYWGAPIPIIYC 439 E+V+ L I ++K ++DW ISRQ +WG IP YC Sbjct: 350 QWWLRMRPLAEEVLKGLRRGDIAFVPERWKKVNMDWLENVKDWNISRQLWWGHQIPAWYC 409 Query: 440 EKCGVVPVPEEDLPVRLPKDVEFLPTGQSPLSFHEGFKKTKCPVCGG-EAQRETDTMDTF 498 E C V VP P R +D T C CG +R+ D DT+ Sbjct: 410 EDCQAVNVPR---PERYLED------------------PTSCEACGSPRLKRDEDVFDTW 448 Query: 499 VDSSWYFLRYVNPHLEDKPFEPDDVNYWLPVDQYIGGVEHAVLHLLYSRFVTKVLHDLGY 558 S+ + L + P E +D+ + P D + G + +L L SR H +G Sbjct: 449 FSSALWPLSTLG-----WPEETEDLKAFYPGDVLVTGYD--ILFLWVSRMEVSGYHFMG- 500 Query: 559 LNFDEPFTNLFTQGMIYKD-GAKMSKSKGNVVSPDEMIEKYGADTLRMYILFMAPPEKDA 617 + PF + G++ + G KMSKSKGNV+ P EM+E+YGAD LR ++++A +D Sbjct: 501 ---ERPFKTVLLHGLVLDEKGQKMSKSKGNVIDPLEMVERYGADALRFALIYLATGGQDI 557 Query: 618 EWSDAGIEGVHRFVKRLWNTFYTVL----PFVKEENTENLVLKNSTEKELRRKLHSIIKK 673 +E F +L+N VL F +E+T L ++ +R +L +++ Sbjct: 558 RLDLRWLEMARNFANKLYNAARFVLLSREGFQAKEDTPTL-----ADRFMRTRLSRGVEE 612 Query: 674 ITEDIEGGFKFNTAISGLMELV--NHLSQYLNSVPQ-----EEWNRKLLREIVEKLTLAL 726 IT E A + ELV YL + + L E++ L L Sbjct: 613 ITALYE-ALDLAQAAREVYELVWSEFCDWYLEAAKPALKAGNAHTLRTLEEVLAVLLKLL 671 Query: 727 SPFAPHLAEEFWHDLGNDSLVVQQSWPSYDPKALEVEEVEIAIQ 770 P P L E + L + ++WP + E E A++ Sbjct: 672 HPMMPFLTSELYQALTGKEELALEAWPEPGGRDEEAERAFEALK 715dbj|BAA24690| (AB010832) ORF3; putative leucyl-tRNA synthase [Symbiobacterium thermophilum] Length = 143 Score = 178 bits (446), Expect = 2e-43 Identities = 73/111 (65%), Positives = 94/111 (83%) Query: 31 KPKYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAENAAI 90 +PKYYAL MFPYPSG LH+GHV+NY I D++ARY+RM+GYNVLHP G+D+FG+PAENAAI Sbjct: 33 RPKYYALAMFPYPSGKLHMGHVRNYTIVDVIARYRRMKGYNVLHPMGFDSFGMPAENAAI 92 Query: 91 EKGIHPEEWTRKNIATIRQQVKKLGISYDWSREIATCDEEYYKWTQWIFLQ 141 + G +P WTR+NIA + Q+K++G SYDWSR + T E+YY+WTQW+FLQ Sbjct: 93 QHGANPAVWTRENIAEMTAQLKQMGYSYDWSRAVYTYREDYYRWTQWLFLQ 143sp|O27552|SYL_METTH LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS) >gi|2622626 (AE000911) leucyl-tRNA synthetase [Methanobacterium thermoautotrophicum] Length = 937 Score = 171 bits (429), Expect = 2e-41 Identities = 196/893 (21%), Positives = 335/893 (36%), Gaps = 196/893 (21%) Query: 30 EKPKYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAENAA 89 ++ K + V +PYPSG +H+GH + Y + D+ AR+KRM+GYNVL P + G P A Sbjct: 23 DREKIFLTVAYPYPSGAMHIGHGRTYTVPDVYARFKRMQGYNVLFPMAWHVTGAPVIGIA 82 Query: 90 ------------------------IEKGIHPEEWTRKNIATIRQQVKKLGISYDWSREIA 125 +E+ PE R ++ +G S DW RE Sbjct: 83 RRIQRKDPWTLKIYREVHRVPEDELERFSDPEYIVEYFSREYRSVMEDMGYSIDWRREFK 142 Query: 126 TCDEEYYKWTQWIFLQLYKNGLAYKKKAAVNWCPKCKTVLANEQVKDGKCERCGTSVTIR 185 T D Y ++ QW +L GL K V +CP+C+ + + + +G+ V I Sbjct: 143 TTDPTYSRFIQWQIRKLRDLGLVRKGAHPVKYCPECENPVGDHDLLEGE------GVAIN 196 Query: 186 HLEQWFFKITDYAERLLNDLDKLTGWPEHVKTMQRNWIGKSTGAEIDFPVEGSDTKIRVF 245 L FK+ D+ + Sbjct: 197 QLTLLKFKL-------------------------------------------GDSYLVAA 213 Query: 246 TTRPDTLWGVTFMXXXXXXXXXXXXXXXXXXXXXXXXXXRVKQQDRFRRTSVEAEKEGFF 305 T RP+T++G T + + Q + S + G Sbjct: 214 TFRPETIYGATNLWLNPDEDYVRVETGGEEWIISRAAVDNLSHQKLDLKVSGDV-NPGDL 272 Query: 306 LGRYAINPVTGERIPIYVANYILMEYGTGAIMGVPAHDQRDF----------SFAKKYGI 355 +G NPVTG+ PI A+++ EY TG + VPAH DF ++YG+ Sbjct: 273 IGMCVENPVTGQEHPILPASFVDPEYATGVVFSVPAHAPADFIALEDLRTDHELLERYGL 332 Query: 356 --------PIKVVI--------------KPADKDLDPEKMEEA-------YEGEGIMVNS 386 P+ V+ K ++ + ++E+A G+M + Sbjct: 333 EDVVADIEPVNVIAVDGYGEFPAAEVIEKFGVRNQEDPRLEDATGELYKIEHARGVMSSH 392 Query: 387 GP-FDGTPSSEGIEKVINWLEEKGIGKRSVQYKLRDWLISRQRYWGAPIPIIYCEKCG-- 443 P + G SE E + + L+++G+ ++ R P+I +CG Sbjct: 393 IPVYGGMKVSEAREVIADELKDQGLADEMYEFAER--------------PVIC--RCGGR 436 Query: 444 -VVPVPEE------------DLPVRLPKDVEFLPTG-QSPLSFH-EGFKKTKCPVCGGEA 488 VV V E+ DL R ++ +P ++ ++ + C G Sbjct: 437 CVVRVMEDQWFMKYSDDAWKDLAHRCLDGMKIIPEEVRANFEYYIDWLNDWACSRRIGLG 496 Query: 489 QR----ETDTMDTFVDSSWYFLRYVNPH---------LEDKPFEP-------------DD 522 R E ++ DS+ Y Y H ++D+ F+ ++ Sbjct: 497 TRLPWDERWIIEPLTDSTIYMAYYTIAHRLREMDAGEMDDEFFDAIFLDDSGTFEDLREE 556 Query: 523 VNYWLPVDQYIGGVEHAVLHLLYSRF-VTKVLHDLGYLNFDEPFTNLFTQGMIYKDGAKM 581 YW P+D + + HL + F + + + G+ F GM +G KM Sbjct: 557 FRYWYPLDWRLSAKDLIGNHLTFHIFHHSAIFPESGWPRGAVVF------GMGLLEGNKM 610 Query: 582 SKSKGNVVSPDEMIEKYGADTLRMYILFMAPPEKDAEWSDAGIEGVHRFVKRLWNTFYTV 641 S SKGNV+ + IEK+GAD +R++++ A P +D +W ++ + G R ++ V Sbjct: 611 SSSKGNVILLRDAIEKHGADVVRLFLMSSAEPWQDFDWRESEVIGTRRRIEWFREFGERV 670 Query: 642 LPFVKEENTENLVLKNSTEKELRR----KLHSIIKKITEDIEGGFKFNTAISGLMELVNH 697 + + V E + R +L+ I++ T +E L L Sbjct: 671 SGILDGRPVLSEVTPAEPESFIGRWMMGQLNQRIREATRALESFQTRKAVQEALYLLKKD 730 Query: 698 LSQYLNSVP--QEEWNRKLLREIVEKLTLALSPFAPHLAEEFWHDLGNDSLVVQQSWPSY 755 + YL V ++ + +L ++ ++PF P+ AEE W G + V + WP + Sbjct: 731 VDHYLKRVEGRVDDEVKSVLANVLHAWIRLMAPFIPYTAEEMWERYGGEGFVAEAPWPDF 790 Query: 756 DPKALEVEEVEIAIQ-INGKVRDKVVVPVDISEEDLKRIVLERERVKEYVDGK 807 A E +V++A + + VRD +E +K + ERV Y K Sbjct: 791 SDDA-ESRDVQVAEEMVQNTVRD--------IQEIMKILGSTPERVHIYTSPK 834sp|P56000|SYV_HELPY VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) (VALRS) >gi|2314306|gb|AAD08195.1| (AE000621) valyl-tRNA synthetase (valS) [Helicobacter pylori 26695] Length = 874 Score = 170 bits (427), Expect = 3e-41 Identities = 193/788 (24%), Positives = 304/788 (38%), Gaps = 195/788 (24%) Query: 30 EKPKYYALVMFP-YPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAENA 88 EK K + L+M P +G LH+GH + DI+ARYKRM GY L+ G D G+ +N Sbjct: 39 EKNKRFCLMMPPPNVTGVLHIGHALTLSLQDILARYKRMDGYKTLYQPGLDHAGIATQNV 98 Query: 89 A----IEKGIHPE------------EWTRKNIATIRQQVKKLGISYDWSREIATCDEEYY 132 + +GI E EW K+ I +Q+K+LG+S +SR T D+ Sbjct: 99 VEKQLLSQGIKKEDLGREEFIKKVWEWKEKSGGAILEQMKRLGVSAAFSRTRFTMDKGLQ 158 Query: 133 KWTQWIFLQLYKNGLAYKKKAAVNWCPKCKTVLANEQVKDGKCERCGTSVTIRHLEQWFF 192 + + FL+ Y+ GL + VNWC KDG + +E Sbjct: 159 RAVKLAFLKWYEKGLIIQDNYMVNWC-----------TKDG---------ALSDIE---- 194 Query: 193 KITDYAERLLNDLDKLTGWPEHVKTMQRNWIGKSTGAEIDFPVEGSDTKIRVFTTRPDTL 252 +Y ER K I + +E + V TTRP+TL Sbjct: 195 --VEYEER------------------------KGALYYIRYYLENQKDYLVVATTRPETL 228 Query: 253 WGVTFMXXXXXXXXXXXXXXXXXXXXXXXXXXRVKQQDRFRRTSVEAEKEGFFLGRYAIN 312 +G D + E+ +G+ AI Sbjct: 229 FG-----------------------------------DSALMVNPNDERYKHLVGQKAIL 253 Query: 313 PVTGERIPIYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIP-IKVV----------- 360 P+ IPI ++ ME+GTG + P HD D+ K++ + IK+ Sbjct: 254 PLIHRTIPIIADEHVEMEFGTGCVKVTPGHDFNDYEVGKRHHLETIKIFDEKGILNAHCG 313 Query: 361 -------IKPADKDLDP-------EKMEEAYEGEGIMVNSG--------------PFDGT 392 ++ DK ++ EK+EE G P Sbjct: 314 EFENLERLEARDKVVERLKENALLEKIEEHTHQVGHCYRCHNVVEPYVSKQWFVKPEIAQ 373 Query: 393 PSSEGIEKVI------NWLEEKGIGKRSVQYKLRDWLISRQRYWGAPIPIIYCEKCGVVP 446 S E I++ + NW+ R +LR W ISRQ +WG IP+ CE Sbjct: 374 SSIEKIQQGLARFYPSNWINNYNAWMR----ELRPWCISRQLFWGHQIPVFTCEN----- 424 Query: 447 VPEEDLPVRLPKDVEFLPTGQSPLSFHEGFKKTKCPVCGGEA-QRETDTMDTFVDSS-WY 504 + +F+ +PLS CP C E +++ D +DT+ S W Sbjct: 425 ------------NHQFVSL-DTPLS---------CPTCKSETLEQDKDVLDTWFSSGLWA 462 Query: 505 FLRYVNPHLEDKPFEPDDVNYWLPVDQYIGGVEHAVLHLLYSRFVTKVLHDLGYLNFDEP 564 F + F D+ + P I G + + F ++ L LG L P Sbjct: 463 FSTLGWGQEKSGLFNESDLKDFYPNTTLITGFDILFFWVARMLFCSESL--LGEL----P 516 Query: 565 FTNLFTQGMIYKD-GAKMSKSKGNVVSPDEMIEKYGADTLRMYILFMAPPEKDAEWSDAG 623 F +++ ++ + G KMSKSKGNV+ P EMIEKYGAD+LR + + +D + S Sbjct: 517 FKDIYLHALVRDEKGEKMSKSKGNVIDPLEMIEKYGADSLRFTLANLCATGRDIKLSTTH 576 Query: 624 IEGVHRFVKRLWNTFYTVLPFVKEENTENLVLKNSTEKELRRKLHSIIKKITEDIEG--- 680 +E F +L+N + +K+E+ ++ N + L R S + T++ Sbjct: 577 LENNKNFANKLFNAASYLK--LKQESFKDKERLNEYQTPLGRYAKSRLNSATKEARNALD 634 Query: 681 GFKFNTAISGLMELV--NHLSQYLNSVPQEEWNRKLLREIVEKLTLALSPFAPHLAEEFW 738 ++FN A + L + ++ E L ++++ L PF P ++E + Sbjct: 635 NYRFNDATTLLYRFLWGEFCDWFIEFSKVENEAIDELGSVLKEALKLLHPFMPFISESLY 694 Query: 739 HDLGNDSL 746 H L N L Sbjct: 695 HKLSNTEL 702gi|4155674 (AE001535) VALYL-TRNA SYNTHETASE [Helicobacter pylori J99] Length = 872 Score = 166 bits (416), Expect = 7e-40 Identities = 188/788 (23%), Positives = 301/788 (37%), Gaps = 195/788 (24%) Query: 30 EKPKYYALVMFP-YPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAENA 88 EK K + L+M P +G LH+GH + DI+ RYKRM GY L+ G D G+ +N Sbjct: 37 EKGKRFCLMMPPPNVTGILHIGHALTLSLQDILVRYKRMDGYKTLYQPGLDHAGIATQNV 96 Query: 89 A----IEKGIHPE------------EWTRKNIATIRQQVKKLGISYDWSREIATCDEEYY 132 + +G+ E EW K+ I +Q+K+LG+S +SR T D+ Sbjct: 97 VEKQLLSQGVKKEDLGREKFIQKVWEWKEKSGGAILEQMKRLGVSTAFSRTRFTMDKGLQ 156 Query: 133 KWTQWIFLQLYKNGLAYKKKAAVNWCPKCKTVLANEQVKDGKCERCGTSVTIRHLEQWFF 192 + + FL+ Y+ GL + VNWC KDG + +E Sbjct: 157 RAVKLAFLKWYEKGLIVQDNYMVNWC-----------TKDG---------ALSDIE---- 192 Query: 193 KITDYAERLLNDLDKLTGWPEHVKTMQRNWIGKSTGAEIDFPVEGSDTKIRVFTTRPDTL 252 +Y ER K I + +E + V TTRP+TL Sbjct: 193 --VEYEER------------------------KGALYYIRYYLENQKDYLVVATTRPETL 226 Query: 253 WGVTFMXXXXXXXXXXXXXXXXXXXXXXXXXXRVKQQDRFRRTSVEAEKEGFFLGRYAIN 312 +G D + E+ +G+ I Sbjct: 227 FG-----------------------------------DSAIMVNPNDERYKHLVGQQVIL 251 Query: 313 PVTGERIPIYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIP-IKV------------ 359 P+ IPI ++ M +GTG + P HD D+ K++ + IK+ Sbjct: 252 PLINRTIPIIADAHVEMGFGTGCVKVTPGHDFNDYEVGKRHHLETIKIFDEKGILNAHCG 311 Query: 360 -------------VIKPADKDLDPEKMEEAYEGEGIMVNSG--------------PFDGT 392 V+ ++ EK+EE G P Sbjct: 312 EFENLERLEARDKVVAALKENALLEKIEEHVHQVGHCYRCHNVVEPYVSKQWFVKPEIAQ 371 Query: 393 PSSEGIEKVI------NWLEEKGIGKRSVQYKLRDWLISRQRYWGAPIPIIYCEKCGVVP 446 S E I++ + NW+ R +LR W ISRQ +WG IP+ CE Sbjct: 372 SSIEKIQQGLARFYPSNWINNYNAWMR----ELRPWCISRQLFWGHQIPVFTCEN----- 422 Query: 447 VPEEDLPVRLPKDVEFLPTGQSPLSFHEGFKKTKCPVCGGEA-QRETDTMDTFVDSS-WY 504 + +F+ +PLS CP C E +++ D +DT+ S W Sbjct: 423 ------------NHQFVSL-DTPLS---------CPTCKSEKLEQDKDVLDTWFSSGLWA 460 Query: 505 FLRYVNPHLEDKPFEPDDVNYWLPVDQYIGGVEHAVLHLLYSRFVTKVLHDLGYLNFDEP 564 F + F D+ + P I G + + F ++ L LG L P Sbjct: 461 FSTLGWGQEKSDLFNESDLKDFYPNTTLITGFDILFFWVARMLFCSESL--LGEL----P 514 Query: 565 FTNLFTQGMIYKD-GAKMSKSKGNVVSPDEMIEKYGADTLRMYILFMAPPEKDAEWSDAG 623 F +++ ++ + G KMSKSKGNV+ P EMIEKYGAD+LR + + +D + S Sbjct: 515 FKDIYLHALVRDEKGEKMSKSKGNVIDPLEMIEKYGADSLRFTLANLCATGRDIKLSTTH 574 Query: 624 IEGVHRFVKRLWNTFYTVLPFVKEENTENLVLKNSTEKELRRKLHSIIKKITEDIEG--- 680 +E F +L+N + +K+E+ ++ N + L R S + +T+++ Sbjct: 575 LENNKNFANKLFNAASYLK--LKQESFKDKERLNEYQTALGRYAKSRLNLVTKEVRNALD 632 Query: 681 GFKFNTAISGLMELV--NHLSQYLNSVPQEEWNRKLLREIVEKLTLALSPFAPHLAEEFW 738 ++FN A + L + ++ E L ++++ L PF P ++E + Sbjct: 633 NYRFNDATTLLYRFLWGEFCDWFIEFSKVENEAIDELGSVLKEALKLLHPFMPFISESLY 692 Query: 739 HDLGNDSL 746 H L N L Sbjct: 693 HKLSNTEL 700sp|Q55522|SYV_SYNY3 VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) (VALRS) >gi|1001391|dbj|BAA10881| (D64006) valyl-tRNA synthetase [Synechocystis sp.] Length = 910 Score = 165 bits (414), Expect = 1e-39 Identities = 187/841 (22%), Positives = 317/841 (37%), Gaps = 227/841 (26%) Query: 26 PQRSEKPKYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPA 85 P R +P Y ++ P +G+LH+GH + D + RY RMRG N L G D + A Sbjct: 32 PDRPGEP-YCVVIPPPNVTGSLHMGHAFESSLIDTLVRYHRMRGDNTLWLPGTDHASI-A 89 Query: 86 ENAAIEKGIHPE-----------------EWTRKNIATIRQQVKKLGISYDWSREIATCD 128 +E+ + E +W ++ +TI Q+++LG+S DW+RE T D Sbjct: 90 VQTILERQLKAEGKTRDDLGREKFLERAWQWKAESGSTIVNQLRRLGVSVDWTRERFTMD 149 Query: 129 EEYYKWTQWIFLQLYKNGLAYKKKAAVNWCPKCKTVLANEQVKDGKCERCGTSVTIRHLE 188 E + + F++LY+ GL Y+ VNWCP ++ +++ +V++ + + HL Sbjct: 150 EGLSQAVKTAFIKLYEEGLIYRGNYLVNWCPASQSAVSDLEVENQEVDG--------HL- 200 Query: 189 QWFFKITDYAERLLNDLDKLTGWPEHVKTMQRNWIGKSTGAEIDFPVEGSDTKIRVFTTR 248 W+F+ +P+ ++ V TTR Sbjct: 201 -WYFR---------------------------------------YPLTDGSGELVVATTR 220 Query: 249 PDTLWGVTFMXXXXXXXXXXXXXXXXXXXXXXXXXXRVKQQDRFRRTSVEAEKEGFFLGR 308 P+T+ G T + V D E+ +G+ Sbjct: 221 PETMLGDTGVA--------------------------VNPHD---------ERYAAMVGK 245 Query: 309 YAINPVTGERIPIYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIP-IKVVIKPA--- 364 P+ IPI + E+GTG + PAHD DF +++ +P I ++ K Sbjct: 246 TITLPLVNREIPIVADELVDPEFGTGCVKVTPAHDPNDFVMGQRHNLPFINLLNKDGSLN 305 Query: 365 ---------DKDLDPEKMEEAYEGEGIMVNSGPFD-----GTPSSEGIEKVIN--WL--- 405 D+ + + +A E +G +V P+ G +E +++ W Sbjct: 306 ENGGDFAGQDRFEARKNVVQALEAQGFLVKIEPYRHSVPYGDRGKVPVEPLLSTQWFVKI 365 Query: 406 ---------------------EEKGIGKRSVQYKLRDWLISRQRYWGAPIPIIYC--EKC 442 E G R KL+DW ISRQ +WG IP Y E Sbjct: 366 ESLAQNALACLDEDNSPNFVPERWGKVYRDWLVKLKDWCISRQLWWGHQIPAWYVISETN 425 Query: 443 GVVP------VPEEDLPVRLPKDVEFLPTGQSPLSFHEGFKKTKCPVCGGEAQRETDTMD 496 G + V ++ E+ PT Q Q++ D +D Sbjct: 426 GAITDHTPFIVAYDEAEALAKAKAEYGPTVQ--------------------LQQDPDVLD 465 Query: 497 TFVDSS-WYFLRYVNPHLEDKPFEPDDVNYWLPVDQYIGGVEHAVLHLLYSRFVTKVLHD 555 T+ S W F P + DD+ + P + G + ++ +R H Sbjct: 466 TWFSSGLWPFSTMGWPE------QTDDLAKYYPTSTLVTGFD--IIFFWVARMTMMAGHF 517 Query: 556 LGYLNFDEPFTNLFTQGMIY-KDGAKMSKSKGNVVSPDEMIEKYGADTLRMYIL------ 608 G + PF +++ G++ ++G KMSKS N + P +I KYG D LR ++ Sbjct: 518 TGQI----PFKDVYIHGLVRDENGKKMSKSANNGIDPLLLINKYGTDALRYTLIREVAGA 573 Query: 609 -----FMAPPEKDAEWSDAGIEGVHRFVKRLWNTFYTVLPFVKEENTENLVLKNSTEKEL 663 +KD S +E F +LWN V+ + + + L L + EL Sbjct: 574 GQDISLQYDRQKDESES---VEASRNFANKLWNAARFVMMNLDGQTPQQLGLAPGEDLEL 630 Query: 664 R-----RKLHSIIKKITEDIEGGFKFNTAISGLMELV--NHLSQYLNSVPQEEWN----- 711 +L+ +I++ E IE + A GL E + + Y+ WN Sbjct: 631 ADRWILSRLNQVIQQTREQIE-DYGLGEAAKGLYEFIWGDFCDWYIELAKPRLWNKEGGD 689 Query: 712 ---------RKLLREIVEKLTLALSPFAPHLAEEFWHDL--GNDSLVVQQSWPSYDPKAL 760 R++L ++ + L PF PH+ EE W L + Q++P+ + + Sbjct: 690 VGTQRQLVARQVLAHTLDSIIKLLHPFMPHITEELWQTLHQAEGQFLALQAYPTVNQSLV 749 Query: 761 E 761 + Sbjct: 750 D 750pir||A64379 isoleucine--tRNA ligase (EC 6.1.1.5) - Methanococcus jannaschii Length = 942 Score = 162 bits (406), Expect = 1e-38 Identities = 205/867 (23%), Positives = 343/867 (38%), Gaps = 158/867 (18%) Query: 30 EKPKYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAENAA 89 ++ K++ FPY +G LH GH++ + I ++VAR++RM+ NVL FGY G P A Sbjct: 30 DREKFFITAAFPYLNGVLHAGHLRTFTIPEVVARFQRMKNKNVLWTFGYHVTGTPILGLA 89 Query: 90 I------EKGIH------------------PEEWTRKNIATIRQQVKKLGISYDWSREIA 125 EK I PE+ + K++G S DW R Sbjct: 90 ELIKNRDEKTIWAYTELHGIPKEELLELTTPEKIVEYFSKKAEEAFKRMGFSLDWRRNFK 149 Query: 126 TCDEEYYKWTQWIFLQLYKNGLAYKKKAAVNWCPKCKTVLANEQVKDGKCERCGTSVTIR 185 T D+ + K+ +W F +L + GL K V +CP+C + + + G + T+ Sbjct: 150 TDDKVFNKFIEWQFHKLKEKGLIVKGSHPVRYCPRCDNPVEDHDI------LVGENATL- 202 Query: 186 HLEQWFFKITDYAERLLNDLDKLTGWPEHVKTMQRNWIGKSTGAEIDFPVEGSDTKIRVF 245 +E K T + + T PE V + W+ E + K +V+ Sbjct: 203 -VEYILIKFTTEDGCI---MPMATLRPETVFGVTNVWVNP----------EATYVKAKVY 248 Query: 246 TTRPDTLWGVTFMXXXXXXXXXXXXXXXXXXXXXXXXXXRVKQQDRFRRTSVEAEKEGFF 305 + +T G+ + ++K QDR + +E K Sbjct: 249 LEK-ETENGIXLI-------------ENGIWIMAKECAEKLKHQDR-KIEIIEEFKGEQL 293 Query: 306 LGRYAINPVTGERIPIYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYG-------IPI- 357 + + NPVTG+ +PI A ++ GTG +M VPAH D+ + G IP+ Sbjct: 294 INKKVKNPVTGKEVPILPAKFVKTNIGTGCVMSVPAHAPYDYIALRDLGLVDEIGLIPLI 353 Query: 358 -----------KVVIKPADKDLDPE-KMEEA----YEGE---GIM-VNSGPFDGTPSSEG 397 ++V K K + E K+EEA Y+ E G++ N ++G P E Sbjct: 354 NVPGYGKYPAKEIVEKMGIKSQEEEDKLEEATKKIYKDEFHKGVLNENCLDYEGIPVREI 413 Query: 398 IEKVINWLEEKGIGKRSVQYKLRDWLISRQRYWGAPIPIIYCEKCGVVPVPEE---DLPV 454 +K+ L +KG+ + ++ + +I R G P + + + +E +L Sbjct: 414 KDKLTKDLIDKGLAEIMYEFS-EEKVICR---CGTPCIVKMVKGQWFIKYSDEKWKELAH 469 Query: 455 RLPKDVEFLPTGQSPLSFHEGFKKTKCPVCGGEAQRETD-------TMDTFVDSSWY--- 504 + + F+P + FHE K C T +++ DS+ Y Sbjct: 470 KCIDKMRFIPENLRQV-FHEKIDWMKDKACVRRRGLGTKFPFEEGWVIESLSDSTIYPAY 528 Query: 505 --FLRYVNPH----------LEDKPF--------------EPDDV--------NYWLPVD 530 +Y+N H L D F P D+ Y+ PVD Sbjct: 529 YTVAKYINQHNIKPEQLTLELFDYVFLGKGDVDKIAKETGIPKDIIEGMRKEFIYYYPVD 588 Query: 531 QYIGGVEHAVLHLLYSRFVTKVLHDLGYLNFDEPF--TNLFTQGMIYKDGAKMSKSKGNV 588 + HL + F + F E F + G + +G K+SKSKG V Sbjct: 589 WRCSAKDLIPNHLTFYIFNHVAI-------FPEEFWPRGIVVNGYVTIEGKKLSKSKGPV 641 Query: 589 VSPDEMIEKYGADTLRMYILFMAPPEKDAEWSDAGIEGVHRFVKRLWNTFYTVLPFVKEE 648 + E+ EK+GAD R YI A +DA+ +E + ++RL Y + E Sbjct: 642 LPVLEVAEKFGADVGRFYITTCAELPQDADIKFKEMENTKKVLERL----YLFAKEIAER 697 Query: 649 NTENLVLKNSTEKELRRKLHSIIKKITEDIEGGFKFNTAISGLMELVNHLSQYLNSVPQE 708 E + +K L +L+ +K+ E +E F+ A L +L++ L Y Sbjct: 698 RGETGEEFSYIDKWLLSRLYKAVKQYDEYME-NFELRKAGILLYQLLDDLKWYRRRGGN- 755 Query: 709 EWNRKLLREIVEKLTLALSPFAPHLAEEFWHDLGNDSLVVQQSWPSYDPKALEVEEVEIA 768 N ++L E +E + + PF PHL EE W LG + V +P + + +E+E Sbjct: 756 --NIRVLEEFLEVIIKLMMPFTPHLCEEMWEILGKEGFVSLAKFPEVKEEFIN-DEIEKG 812 Query: 769 IQINGKVRDKVVVPVDISEEDLKRIVL 795 + V + + +++++ KRI L Sbjct: 813 EEYLKAVMEDIKEIINVAKVQPKRIYL 839sp|Q58050|SYL_METJA LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS) >gi|2826301 (U67511) leucyl-tRNA synthetase (leuS) [Methanococcus jannaschii] Length = 942 Score = 162 bits (405), Expect = 1e-38 Identities = 205/867 (23%), Positives = 343/867 (38%), Gaps = 158/867 (18%) Query: 30 EKPKYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAENAA 89 ++ K++ FPY +G LH GH++ + I ++VAR++RM+ NVL FGY G P A Sbjct: 30 DREKFFITAAFPYLNGVLHAGHLRTFTIPEVVARFQRMKNKNVLWTFGYHVTGTPILGLA 89 Query: 90 I------EKGIH------------------PEEWTRKNIATIRQQVKKLGISYDWSREIA 125 EK I PE+ + K++G S DW R Sbjct: 90 ELIKNRDEKTIWAYTELHGIPKEELLELTTPEKIVEYFSKKAEEAFKRMGFSLDWRRNFK 149 Query: 126 TCDEEYYKWTQWIFLQLYKNGLAYKKKAAVNWCPKCKTVLANEQVKDGKCERCGTSVTIR 185 T D+ + K+ +W F +L + GL K V +CP+C + + + G + T+ Sbjct: 150 TDDKVFNKFIEWQFHKLKEKGLIVKGSHPVRYCPRCDNPVEDHDI------LVGENATL- 202 Query: 186 HLEQWFFKITDYAERLLNDLDKLTGWPEHVKTMQRNWIGKSTGAEIDFPVEGSDTKIRVF 245 +E K T + + T PE V + W+ E + K +V+ Sbjct: 203 -VEYILIKFTTEDGCI---MPMATLRPETVFGVTNVWVNP----------EATYVKAKVY 248 Query: 246 TTRPDTLWGVTFMXXXXXXXXXXXXXXXXXXXXXXXXXXRVKQQDRFRRTSVEAEKEGFF 305 + +T G+ + ++K QDR + +E K Sbjct: 249 LEK-ETENGIELI-------------ENGIWIMAKECAEKLKHQDR-KIEIIEEFKGEQL 293 Query: 306 LGRYAINPVTGERIPIYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYG-------IPI- 357 + + NPVTG+ +PI A ++ GTG +M VPAH D+ + G IP+ Sbjct: 294 INKKVKNPVTGKEVPILPAKFVKTNIGTGCVMSVPAHAPYDYIALRDLGLVDEIGLIPLI 353 Query: 358 -----------KVVIKPADKDLDPE-KMEEA----YEGE---GIM-VNSGPFDGTPSSEG 397 ++V K K + E K+EEA Y+ E G++ N ++G P E Sbjct: 354 NVPGYGKYPAKEIVEKMGIKSQEEEDKLEEATKKIYKDEFHKGVLNENCLDYEGIPVREI 413 Query: 398 IEKVINWLEEKGIGKRSVQYKLRDWLISRQRYWGAPIPIIYCEKCGVVPVPEE---DLPV 454 +K+ L +KG+ + ++ + +I R G P + + + +E +L Sbjct: 414 KDKLTKDLIDKGLAEIMYEFS-EEKVICR---CGTPCIVKMVKGQWFIKYSDEKWKELAH 469 Query: 455 RLPKDVEFLPTGQSPLSFHEGFKKTKCPVCGGEAQRETD-------TMDTFVDSSWY--- 504 + + F+P + FHE K C T +++ DS+ Y Sbjct: 470 KCIDKMRFIPENLRQV-FHEKIDWMKDKACVRRRGLGTKFPFEEGWVIESLSDSTIYPAY 528 Query: 505 --FLRYVNPH----------LEDKPF--------------EPDDV--------NYWLPVD 530 +Y+N H L D F P D+ Y+ PVD Sbjct: 529 YTVAKYINQHNIKPEQLTLELFDYVFLGKGDVDKIAKETGIPKDIIEGMRKEFIYYYPVD 588 Query: 531 QYIGGVEHAVLHLLYSRFVTKVLHDLGYLNFDEPF--TNLFTQGMIYKDGAKMSKSKGNV 588 + HL + F + F E F + G + +G K+SKSKG V Sbjct: 589 WRCSAKDLIPNHLTFYIFNHVAI-------FPEEFWPRGIVVNGYVTIEGKKLSKSKGPV 641 Query: 589 VSPDEMIEKYGADTLRMYILFMAPPEKDAEWSDAGIEGVHRFVKRLWNTFYTVLPFVKEE 648 + E+ EK+GAD R YI A +DA+ +E + ++RL Y + E Sbjct: 642 LPVLEVAEKFGADVGRFYITTCAELPQDADIKFKEMENTKKVLERL----YLFAKEIAER 697 Query: 649 NTENLVLKNSTEKELRRKLHSIIKKITEDIEGGFKFNTAISGLMELVNHLSQYLNSVPQE 708 E + +K L +L+ +K+ E +E F+ A L +L++ L Y Sbjct: 698 RGETGEEFSYIDKWLLSRLYKAVKQYDEYME-NFELRKAGILLYQLLDDLKWYRRRGGN- 755 Query: 709 EWNRKLLREIVEKLTLALSPFAPHLAEEFWHDLGNDSLVVQQSWPSYDPKALEVEEVEIA 768 N ++L E +E + + PF PHL EE W LG + V +P + + +E+E Sbjct: 756 --NIRVLEEFLEVIIKLMMPFTPHLCEEMWEILGKEGFVSLAKFPEVKEEFIN-DEIEKG 812 Query: 769 IQINGKVRDKVVVPVDISEEDLKRIVL 795 + V + + +++++ KRI L Sbjct: 813 EEYLKAVMEDIKEIINVAKVQPKRIYL 839dbj|BAA29387.1| (AP000001) 896aa long hypothetical valyl-tRNA synthetase [Pyrococcus horikoshii] Length = 896 Score = 161 bits (404), Expect = 2e-38 Identities = 154/548 (28%), Positives = 240/548 (43%), Gaps = 97/548 (17%) Query: 300 EKEGFFLGRYAINPVTGERIPIYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPIKV 359 E+ +G+ P+ +PI + +GTGA+ D++D + K+Y +P+ + Sbjct: 234 ERYKHLVGKKVKLPIFEREVPILADEDVDPNFGTGAVYNCTYGDEQDIVWQKRYNLPVII 293 Query: 360 VI------------------KPADKDL--DPEKMEEAYEGEGIMVN----------SGPF 389 VI + A K + D EKM Y+ E I P Sbjct: 294 VINEDGTMNENAGPYAGLKIEEARKKIAEDLEKMGLLYKKEKIKHRVLRHTERSSCMAPI 353 Query: 390 DGTPSSEGIEKVINWLEE-----KGIGKRSVQYKLR----------DWLISRQRYWGAPI 434 + P + KV + ++E K I LR DW+ISRQR +G P Sbjct: 354 ELLPKKQWFIKVKDLIDEIIKVAKEINWYPEDMFLRLKDWAESMDWDWVISRQRVFGTPF 413 Query: 435 PIIYCEKCGVVPVPEEDLPVRLPKDVEFLPTGQSPLSFHEGFKKTKCPVCGGEAQRETDT 494 P C+ ++P EEDLPV D F + P+ KCPVCG E + TD Sbjct: 414 PFWVCKNGHIIPAREEDLPV----DPRF---DKPPVD--------KCPVCGAEIEPVTDV 458 Query: 495 MDTFVDSSWYFLRYVNPHLEDKPFEPDDVNYWL----PVDQYIGGVEHAVLHLLYSRFVT 550 +D +VDSS L H K E + W P G + Y+ T Sbjct: 459 LDCWVDSSITPLIITKWHEAIKGDE--EAKKWFEHNFPTALRPQGTDIIRTWAFYTILRT 516 Query: 551 KVLHDLGYLNFDEPFTNLFTQGMIY-KDGAKMSKSKGNVVSPDEMIEKYGADTLRMYILF 609 VL +P+ ++ GM+ DG KMSKS GNVVSP+E+I KYGAD LR++ Sbjct: 517 YVLTG------KKPWKDIVINGMVAGPDGRKMSKSYGNVVSPEEVIPKYGADALRLWTA- 569 Query: 610 MAPPEKDAEWSDAGIEGVHRFVKRLWNTFYTVLPFVKEENTENL--VLKNSTEKELRRKL 667 +APP +D + ++ +RF++++WN + +K+ + E V +K + +L Sbjct: 570 LAPPGEDHPFKWETVDYNYRFLQKVWNIYRFAERHIKDFDYEKYRDVELEPLDKWILSRL 629 Query: 668 HSIIKKITEDIEGGFKFNTAISGLMELVNH--LSQYLNSVPQ----EEWNRKL-----LR 716 H IIK TE++E ++FN L+ + H Y+ + E+ KL L Sbjct: 630 HRIIKFATEELE-RYRFNLITRELITFIWHEVADDYIEMIKYRLYGEDEESKLKAKVALY 688 Query: 717 EIVEKLTLALSPFAPHLAEEFWHDLGNDSL----VVQQSWPSYDPKALEVEEVEIAIQIN 772 E++ + L L+PF PH+ EE +H + + + V SWP Y ++ E +I Sbjct: 689 ELLYNVMLLLAPFVPHITEEIYHAIFKEKIGEKSVHLLSWPEYREDRIDEEAEKI----- 743 Query: 773 GKVRDKVV 780 G++ K+V Sbjct: 744 GELARKIV 751Score = 123 bits (306), Expect = 5e-27 Identities = 69/151 (45%), Positives = 87/151 (56%), Gaps = 11/151 (7%) Query: 31 KPKYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAE-NAA 89 KP Y P+ SGTLH+GHV ++ DI+ARYKRMRGYNVL P G+D GLP E Sbjct: 38 KPSYAIDTPPPFTSGTLHLGHVLSHTWIDIIARYKRMRGYNVLFPQGFDNHGLPTELKVE 97 Query: 90 IEKGI---HPE-------EWTRKNIATIRQQVKKLGISYDWSREIATCDEEYYKWTQWIF 139 E GI PE EWT + I +R+Q ++G S DW E T D+ Y Q Sbjct: 98 KEFGITKDQPEEFLKKCVEWTWQAIEAMRKQFIRIGYSADWDLEYHTMDDWYKAAVQRSL 157 Query: 140 LQLYKNGLAYKKKAAVNWCPKCKTVLANEQV 170 L+ YK GL Y+++ V WCPKC+T LA +V Sbjct: 158 LEFYKKGLIYREEHPVYWCPKCRTSLAKAEV 188emb|CAB50557.1| (AJ248288) valyl-tRNA synthetase (valS) [Pyrococcus abyssi] Length = 891 Score = 157 bits (394), Expect = 3e-37 Identities = 151/538 (28%), Positives = 231/538 (42%), Gaps = 97/538 (18%) Query: 300 EKEGFFLGRYAINPVTGERIPIYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPIKV 359 E+ +G+ P+ +PI + +GTGA+ D++D + K+Y +P+ + Sbjct: 229 ERYKHLVGKKVKLPIYEREVPILADEDVDPNFGTGAVYNCTYGDEQDIVWQKRYNLPVII 288 Query: 360 VI------------------KPADKDL--DPEKMEEAYEGEGIMVN----------SGPF 389 I + A K + D EKM Y+ E I P Sbjct: 289 AINEDGTMNENAGPYAGLKVEEARKKIAEDLEKMGLLYKKEKIKHRVLRHTERSSCMAPI 348 Query: 390 DGTPSSEG-------------IEKVINWLEEKGIGKRS--VQYKLRDWLISRQRYWGAPI 434 + P + + K INW E + + DW+ISRQR +G P Sbjct: 349 ELLPKKQWFIRVKDFTDEIVKVAKEINWYPEDMFLRLKDWAESMDWDWVISRQRVFGTPF 408 Query: 435 PIIYCEKCGVVPVPEEDLPVRLPKDVEFLPTGQSPLSFHEGFKKTKCPVCGGEAQRETDT 494 P C+ ++P EEDLPV D F + P+ KCPVCG E + TD Sbjct: 409 PFWVCKNGHIIPAREEDLPV----DPRF---DKPPVE--------KCPVCGAEIEPVTDV 453 Query: 495 MDTFVDSSWYFLRYVNPHLEDKPFEPDDVNYWL----PVDQYIGGVEHAVLHLLYSRFVT 550 +D +VDSS L H K E + W P G + Y+ F T Sbjct: 454 LDCWVDSSITPLIITRWHEAIKGDE--EAKKWFEHNFPTALRPQGTDIIRTWAFYTIFRT 511 Query: 551 KVLHDLGYLNFDEPFTNLFTQGMIY-KDGAKMSKSKGNVVSPDEMIEKYGADTLRMYILF 609 L +P+ ++ GM+ DG KMSKS GNVV+PDE+I KYGAD LR++ Sbjct: 512 FKLTG------KKPWKDIVINGMVAGPDGRKMSKSYGNVVAPDEVIPKYGADALRLWTA- 564 Query: 610 MAPPEKDAEWSDAGIEGVHRFVKRLWNTFYTVLPFVKEENTENL--VLKNSTEKELRRKL 667 +APP +D + ++ RF++++WN + +K+ + E + ++ + +L Sbjct: 565 LAPPGEDHPFKWETVDYNFRFLQKVWNIYRFAERHIKDFDYEKYKDIELEPLDRWILSRL 624 Query: 668 HSIIKKITEDIEGGFKFNTAISGLMELVNH--LSQYLNSV------PQEEWNRK---LLR 716 H IIK TE++E ++FN LM + H Y+ V EE K L Sbjct: 625 HRIIKFATEELE-RYRFNLITRELMTFIWHEVADDYIEMVKYRLYGDDEESKLKAKVALY 683 Query: 717 EIVEKLTLALSPFAPHLAEEFWHDLGNDSL----VVQQSWPSY-----DPKALEVEEV 765 E++ + L L+PF PH+ EE +H + D + V SWP Y D KA ++ E+ Sbjct: 684 ELLYNVMLLLAPFVPHITEEIYHAMFKDKIGEKSVHLLSWPEYREDRIDEKAEKLGEL 741Score = 123 bits (306), Expect = 5e-27 Identities = 69/151 (45%), Positives = 87/151 (56%), Gaps = 11/151 (7%) Query: 31 KPKYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAE-NAA 89 KP Y P+ SGTLH+GHV ++ DI+ARYKRMRGYNVL P G+D GLP E Sbjct: 33 KPSYAIDTPPPFTSGTLHLGHVLSHTWIDIIARYKRMRGYNVLFPQGFDNHGLPTELKVE 92 Query: 90 IEKGI---HPE-------EWTRKNIATIRQQVKKLGISYDWSREIATCDEEYYKWTQWIF 139 E GI PE EWT + I +R+Q ++G S DW E T D+ Y Q Sbjct: 93 KEFGITKDQPEEFLKKCVEWTWQAIEAMRKQFIRIGYSADWDLEYHTMDDWYKAAVQKSL 152 Query: 140 LQLYKNGLAYKKKAAVNWCPKCKTVLANEQV 170 L+ YK GL Y+++ V WCPKC+T LA +V Sbjct: 153 LEFYKKGLIYREEHPVYWCPKCRTSLAKAEV 183gb|AAD50458.1|AF169967_1 (AF169967) LeuS [Flavobacterium johnsoniae] Length = 233 Score = 153 bits (384), Expect = 4e-36 Identities = 83/193 (43%), Positives = 114/193 (59%), Gaps = 16/193 (8%) Query: 23 FYTPQRSEKPKYYALVMFPYPSGT-LHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAF 81 F SEKPK+Y L MFPYPSG LHVGH Y+ D+ +R+KR +G+NVLHP GYD+F Sbjct: 22 FAAKNNSEKPKHYVLDMFPYPSGAGLHVGHPLGYIASDVYSRFKRHQGFNVLHPMGYDSF 81 Query: 82 GLPAENAAIEKGIHPEEWTR-----------KNIATIRQQVKKLGISYDWSREIATCDEE 130 GLPAE AI+ G PE+ TR K IA R+Q+ K+G S+DW+RE+ T + + Sbjct: 82 GLPAEQYAIQTGQRPEDTTRVNIDGGVDKEGKQIAGYRKQLDKIGFSFDWAREVRTSNPD 141 Query: 131 YYKWTQWIFLQLYKNGLAYKKKAAVNWCPKCKTVLANEQVKDGKCER-CGTSVTIRHLEQ 189 YYK TQWIF+QL+ + K+ A + + V E+ + E C +VTI ++ Sbjct: 142 YYKHTQWIFIQLFNSWYCRKQGKAFD---ISELVTVFEESGNALVEAVCDDNVTIFTADE 198 Query: 190 WFFKITDYAERLL 202 W D E++L Sbjct: 199 WKSYSDDQKEKIL 211pir||SYBSVS valine--tRNA ligase (EC 6.1.1.9) - Bacillus stearothermophilus Length = 880 Score = 151 bits (377), Expect = 3e-35 Identities = 194/856 (22%), Positives = 327/856 (37%), Gaps = 209/856 (24%) Query: 41 PYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAENAAIEKGIHPEEWT 100 P +G LH+GH + + DI+ R KRM+GY+VL G D G+ + Sbjct: 49 PNVTGKLHLGHAWDTTLQDIITRMKRMQGYDVLWLPGMDHAGIATQ-------------- 94 Query: 101 RKNIATIRQQVKKLGIS-YDWSREIATCDEEYYKWTQWIFLQLYKNGLAYKKKAAVNWCP 159 A + +++++ G+S YD RE EE +KW + Y W Sbjct: 95 ----AKVEEKLRQQGLSRYDLGREKFL--EETWKWKE-----------EYAGHIRSQWA- 136 Query: 160 KCKTVLANEQVKDGKCERCGTSVTIRHLEQWFFKITDYAERLLNDLDKLTGWPEHVKTMQ 219 K L + ++ G S +R + ++ Y + L+ + + W KT Sbjct: 137 --KLGLGLDYTRERFTLDEGLSKAVREVF-----VSLYRKGLIYRGEYIINWDPVTKTAL 189 Query: 220 RNW---IGKSTGA--EIDFPVEGSDTKIRVFTTRPDTLWGVTFMXXXXXXXXXXXXXXXX 274 + + GA + +P+ I V TTRP+T+ G T + Sbjct: 190 SDIEVVYKEVKGALYHMRYPLADGSGFIEVATTRPETMLGDTAVA--------------- 234 Query: 275 XXXXXXXXXXRVKQQDRFRRTSVEAEKEGFFLGRYAINPVTGERIPIYVANYILMEYGTG 334 + E+ +G+ P+ G IPI Y+ ME+G+G Sbjct: 235 --------------------VHPDDERYKHLIGKMVKLPIVGREIPIIADEYVDMEFGSG 274 Query: 335 AIMGVPAHDQRDFSFAKKYGIPIKVVI----------------------KPADKDLDPE- 371 A+ PAHD DF ++ +P +V+ K +DL + Sbjct: 275 AVKITPAHDPNDFEIGNRHNLPRILVMNEDGTMNENAMQYQGLDRFECRKQIVRDLQEQG 334 Query: 372 ---KMEEAYEGEGIMVNSG----PFDGT-------PSSEGIEKV---------------- 401 K+EE G SG P+ T P +E K+ Sbjct: 335 VLFKIEEHVHSVGHSERSGAVIEPYLSTQWFVKMKPLAEAAIKLQQTDGKVQFVPERFEK 394 Query: 402 --INWLEEKGIGKRSVQYKLRDWLISRQRYWGAPIPIIYCEKCGVVPVPEEDLPVRLPKD 459 ++WLE +RDW ISRQ +WG IP Y ++ G + V E PKD Sbjct: 395 TYLHWLEN-----------IRDWCISRQLWWGHRIPAWYHKETGEIYVDHEP-----PKD 438 Query: 460 VEFLPTGQSPLSFHEGFKKTKCPVCGGEAQRETDTMDTFVDSS-WYFLRYVNPHLEDKPF 518 +E +++ D +DT+ S+ W F P + Sbjct: 439 IE-------------------------NWEQDPDVLDTWFSSALWPFSTMGWPDTDS--- 470 Query: 519 EPDDVNYWLPVDQYIGGVEHAVLHLLYSRFVTKVLHDLGYLNFDEPFTNLFTQGMIYK-D 577 PD Y+ P D + G + ++ SR + + L G PF ++ G++ Sbjct: 471 -PDYKRYY-PTDVLVTGYD--IIFFWVSRMIFQGLEFTG----KRPFKDVLIHGLVRDAQ 522 Query: 578 GAKMSKSKGNVVSPDEMIEKYGADTLRMYILFMAPPEKDAEWSDAGIEGVHRFVKRLWNT 637 G KMSKS GN V P ++I++YGAD LR ++ + P +D +S +E F ++WN Sbjct: 523 GRKMSKSLGNGVDPMDVIDQYGADALRYFLATGSSPGQDLRFSTEKVEATWNFANKIWNA 582 Query: 638 FYTVLPFVKEENTENLVL---KNSTEKELRRKLHSIIK---KITEDIEGGFKFNTAISGL 691 L + E L L K + + +L+ I+ K+ E E G + T + + Sbjct: 583 SRFALMNMGGMTYEELDLSGEKTVADHWILTRLNETIETVTKLAEKYEFGERGRTLYNFI 642 Query: 692 ME-------LVNHLSQYLNSVPQEEWNRKLLREIVEKLTLALSPFAPHLAEEFWHDLGND 744 + + L Y + ++ R +L +++ L PF P + EE W +L ++ Sbjct: 643 WDDLCDWYIEMAKLPLYGDDEAAKKTTRSVLAYVLDNTMRLLHPFMPFITEEIWQNLPHE 702 Query: 745 -SLVVQQSWPSYDPKALE---VEEVEIAIQINGKVRDKVVVPVDISEEDLKRIVLERERV 800 + WP P+ EE+ + + I VR+ V +++ K I L + Sbjct: 703 GESITVAPWPQVRPELSNEEAAEEMRMLVDIIRAVRN---VRAEVNTPPSKPIALYIKTK 759 Query: 801 KEYVDGKPIRKFIYVK 816 E+V ++ Y++ Sbjct: 760 DEHVRAALLKNRAYLE 775Database: Non-redundant GenBank CDS translations+PDB+SwissProt+SPupdate+PIR Posted date: Jan 12, 2000 2:26 PM Number of letters in database: 136,724,657 Number of sequences in database: 444,417 Lambda K H 0.319 0.139 0.429 Gapped Lambda K H 0.270 0.0470 0.230 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 235358595 Number of Sequences: 444417 Number of extensions: 10917900 Number of successful extensions: 27891 Number of sequences better than 10.0: 277 Number of HSP's better than 10.0 without gapping: 242 Number of HSP's successfully gapped in prelim test: 35 Number of HSP's that attempted gapping in prelim test: 26518 Number of HSP's gapped (non-prelim): 860 length of query: 824 length of database: 136,724,657 effective HSP length: 54 effective length of query: 770 effective length of database: 112,726,139 effective search space: 86799127030 effective search space used: 86799127030 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.8 bits) X3: 64 (24.9 bits) S1: 41 (21.7 bits) S2: 74 (33.2 bits)