BLASTP 2.0.10 [Aug-26-1999] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402.Query= a q (404 letters) Database: Non-redundant GenBank CDS translations+PDB+SwissProt+SPupdate+PIR 444,417 sequences; 136,724,657 total letters
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Score E Sequences producing significant alignments: (bits) Value sp|O51933|SAHH_THEMA ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-H... 767 0.0 gi|2738603 (AF013268) S adenosylhomocysteine hydrolase [The... 765 0.0 emb|CAB50407.1| (AJ248287) adenosylhomocysteinase (ahcY) [P... 471 e-132 sp|O58275|SAHH_PYRHO ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-H... 460 e-129 dbj|BAA29629| (AP000002) 425aa long hypothetical S-adenosyl... 460 e-129 sp|O28279|SAHH_ARCFU ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-H... 460 e-128 sp|Q58783|SAHH_METJA ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-H... 439 e-122 sp|O27673|SAHH_METTH ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-H... 431 e-120 sp|O67240|SAHH_AQUAE ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-H... 420 e-117 emb|CAB57547.1| (Y18930) s-adenosylhomocysteine hydrolase [... 408 e-113 sp|P50252|SAHH_SULSO ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-H... 408 e-113 dbj|BAA79594.1| (AP000060) 399aa long hypothetical adenosyl... 385 e-106 sp|P74008|SAHH_SYNY3 ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-H... 367 e-101 sp|O93477|SAH2_XENLA ADENOSYLHOMOCYSTEINASE 2 (S-ADENOSYL-L... 298 4e-80 sp|P51893|SAH1_XENLA ADENOSYLHOMOCYSTEINASE 1 (S-ADENOSYL-L... 298 4e-80 pir||A43629 adenosylhomocysteinase (EC 3.3.1.1) - human >gi... 289 2e-77 pdb|1B3R|A Chain A, Rat Liver S-Adenosylhomocystein Hydrola... 289 3e-77 sp|P10760|SAHH_RAT ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOM... 289 3e-77 sp|P50247|SAHH_MOUSE ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-H... 289 3e-77 sp|P23526|SAHH_HUMAN ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-H... 287 8e-77 sp|O13639|SAHH_SCHPO ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-H... 284 1e-75 sp|O76757|SAHH_ANOGA ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-H... 281 8e-75 sp|Q27580|SAHH_DROME ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-H... 281 8e-75 sp|P10819|SAHH_DICDI ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-H... 277 1e-73 pdb|1A7A|A Chain A, Structure Of Human Placental S-Adenosyl... 273 1e-72 sp|P27604|SAHH_CAEEL ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-H... 268 4e-71 ref|NP_010961.1|SAH1| putative S-adenosyl-L-homocysteine hy... 264 8e-70 sp|P36889|SAHH_LEIDO ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-H... 261 6e-69 pir||A45569 adenosylhomocysteinase (EC 3.3.1.1) - Leishmani... 261 7e-69 sp|O08364|SAHH_MYCTU ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-H... 250 1e-65 sp|P51540|SAHH_TRIVA ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-H... 247 9e-65 sp|O50562|SAHH_RHOSH ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-H... 247 1e-64 sp|P50250|SAHH_PLAF7 ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-H... 245 6e-64 dbj|BAA34645| (AB020211) S-adenosyl L-homocystein hydrolase... 244 1e-63 sp|Q12663|SAHH_PNECA ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-H... 240 1e-62 sp|P28183|SAHH_RHOCA ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-H... 237 1e-61 sp|P32112|SAHH_WHEAT ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-H... 236 2e-61 sp|P50246|SAHH_MEDSA ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-H... 236 3e-61 sp|Q01781|SAHH_PETCR ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-H... 235 4e-61 sp|P35007|SAHH_CATRO ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-H... 235 7e-61 gb|AAD56048.1|AF185635_1 (AF185635) S-adenosyl-L-homocystei... 233 2e-60 sp|P93253|SAHH_MESCR ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-H... 232 3e-60 pir||A46035 adenosylhomocysteinase (EC 3.3.1.1) - Rhodobact... 232 5e-60 sp|O23255|SAHH_ARATH ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-H... 231 6e-60 dbj|BAA74851.1| (AB020635) KIAA0828 protein [Homo sapiens] 231 1e-59 sp|P50249|SAHH_PHASS ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-H... 231 1e-59 sp|P50248|SAHH_TOBAC ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-H... 229 3e-59 emb|CAB09795| (Z97059) S-adenosyl-L-homocysteine hydrolase ... 228 7e-59 emb|CAB43223.1| (AL049954) hypothetical protein [Homo sapiens] 227 1e-58 ref|NP_006612.1|| S-adenosylhomocysteine hydrolase-like 1 >... 227 1e-58 dbj|BAA03710| (D16139) cytokinin binding protein CBP57 [Nic... 225 4e-58 gb|AAD50775.1|AF161705_1 (AF161705) S-adenosyl-l-homocystei... 225 6e-58 sp|P50245|SAH2_DROME PUTATIVE ADENOSYLHOMOCYSTEINASE (S-ADE... 222 5e-57 pir||S01302 hypothetical protein, 58K (bithorax complex-der... 220 2e-56 sp|P50251|SAHH_PYRFU ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-H... 151 8e-36 gb|AAD52668.2| (AF178115) S-adenosyl-L-homocysteine hydrola... 146 4e-34 gi|169661 (M62756) S-adenosylhomocysteine hydrolase [Petros... 139 3e-32 gb|AAF19001.1|AF212157_1 (AF212157) S-adenosylhomocysteine ... 129 5e-29 gb|AAD20318| (AF105295) S-adenosyl-homocysteine hydrolase l... 120 2e-26 gi|2661083 (AF035319) similar to S-adenosylhomocysteine hyd... 115 9e-25 pir||S06394 adenosylhomocysteinase (EC 3.3.1.1) - slime mol... 106 3e-22 gi|2649719 (AE001043) S-adenosylhomocysteinase hydrolase (a... 101 9e-21 gb|AAD56027.1|AF181566_1 (AF181566) S-adenosyl-L-homocystei... 92 6e-18 sp|P26799|SAHH_STRFR ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-H... 83 4e-15 gb|AAD29674.1|AF129871_1 (AF129871) S-adenosyl-L-homocystei... 74 2e-12 gb|AAD52667.2| (AF178114) S-adenosyl-L-homocysteine hydrola... 50 3e-05 sp|Q02138|ILVC_LACLA KETOL-ACID REDUCTOISOMERASE (ACETOHYDR... 38 0.15 sp|Q00858|CGPB_FUSSO CUTINASE GENE PALINDROME-BINDING PROTE... 37 0.33 sp|P50100|IMDH_METKA PUTATIVE INOSINE-5'-MONOPHOSPHATE DEHY... 36 0.75 gb|AAD32178.1|AF125563_3 (AF125563) ketol-acid reductoisome... 34 2.9 sp|O30913|EFG_BORBU ELONGATION FACTOR G (EF-G) >gi|2688449 ... 34 2.9 gi|2460295 (AF021260) elongation factor G homolog [Borrelia... 34 2.9 gb|AAD19960| (AF109913) plasma membrane H+-ATPase [Pichia a... 33 4.9 sp|Q05756|GLTD_AZOBR GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN... 33 4.9 emb|CAB50538.1| (AJ248288) hypothetical protein [Pyrococcus... 32 6.5 sp|P15890|YR18_THEPE HYPOTHETICAL 18.7 KD PROTEIN IN RIBOSO... 32 6.5 sp|P05324|HIS4_METVA PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZO... 32 6.5 emb|CAA74413.1| (Y14077) Hypothetical protein [Bacillus sub... 32 8.5sp|O51933|SAHH_THEMA ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE) >gi|4980667|gb|AAD35265.1|AE001702_5 (AE001702) adenosylhomocysteinase [Thermotoga maritima] Length = 404 Score = 767 bits (1959), Expect = 0.0 Identities = 390/404 (96%), Positives = 390/404 (96%) Query: 1 MNTGEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKV 60 MNTGEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKV Sbjct: 1 MNTGEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKV 60 Query: 61 VITGSNPLSTQDDVAEALRSKGITVYARRTHDESIYRENLMKVLDERPDFIIDDGGDLTV 120 VITGSNPLSTQDDVAEALRSKGITVYARRTHDESIYRENLMKVLDERPDFIIDDGGDLTV Sbjct: 61 VITGSNPLSTQDDVAEALRSKGITVYARRTHDESIYRENLMKVLDERPDFIIDDGGDLTV 120 Query: 121 ISHTEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQ 180 ISHTEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQ Sbjct: 121 ISHTEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQ 180 Query: 181 STWDAIMRNTNLLVAGKNVVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGF 240 STWDAIMRNTNLLVAGKNVVVAGYGWC VIVTEVDPVKAVEAIMDGF Sbjct: 181 STWDAIMRNTNLLVAGKNVVVAGYGWCGRGIALRAAGLGARVIVTEVDPVKAVEAIMDGF 240 Query: 241 TVMPMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVE 300 TVMPMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVE Sbjct: 241 TVMPMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVE 300 Query: 301 KFEARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHR 360 KFEARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHR Sbjct: 301 KFEARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHR 360 Query: 361 KMSPKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYLRSWQ 404 KMSPKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYLRSWQ Sbjct: 361 KMSPKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYLRSWQ 404gi|2738603 (AF013268) S adenosylhomocysteine hydrolase [Thermotoga maritima] Length = 404 Score = 765 bits (1953), Expect = 0.0 Identities = 388/404 (96%), Positives = 389/404 (96%) Query: 1 MNTGEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKV 60 MNTGEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLE KTAYLA+TLSKLGAKV Sbjct: 1 MNTGEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLERKTAYLAVTLSKLGAKV 60 Query: 61 VITGSNPLSTQDDVAEALRSKGITVYARRTHDESIYRENLMKVLDERPDFIIDDGGDLTV 120 VITGSNPLSTQDDVAEALRSKGITVYARRTHDESIYRENLMKVLDERPDFIIDDGGDLTV Sbjct: 61 VITGSNPLSTQDDVAEALRSKGITVYARRTHDESIYRENLMKVLDERPDFIIDDGGDLTV 120 Query: 121 ISHTEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQ 180 ISHTEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQ Sbjct: 121 ISHTEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQ 180 Query: 181 STWDAIMRNTNLLVAGKNVVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGF 240 STWDAIMRNTNLLVAGKNVVVAGYGWC VIVTEVDPVKAVEAIMDGF Sbjct: 181 STWDAIMRNTNLLVAGKNVVVAGYGWCGRGIALRAAGLGARVIVTEVDPVKAVEAIMDGF 240 Query: 241 TVMPMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVE 300 TVMPMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVE Sbjct: 241 TVMPMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVE 300 Query: 301 KFEARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHR 360 KFEARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHR Sbjct: 301 KFEARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHR 360 Query: 361 KMSPKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYLRSWQ 404 KMSPKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYLRSWQ Sbjct: 361 KMSPKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYLRSWQ 404emb|CAB50407.1| (AJ248287) adenosylhomocysteinase (ahcY) [Pyrococcus abyssi] Length = 422 Score = 471 bits (1200), Expect = e-132 Identities = 235/401 (58%), Positives = 288/401 (71%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G KI+WVSR+MP+L I E+ +KP G + ++HLE KTA+L +TL GAKV Sbjct: 19 GMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLLTLKAGGAKVSAA 78 Query: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIYRENLMKVLDERPDFIIDDGGDLTVISH 123 SNPLSTQDDV AL +G+ VYA R + Y E + K LD RP+ IIDDG D+ + H Sbjct: 79 ASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIRPNIIIDDGADMVSLVH 138 Query: 124 TEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQSTW 183 TER+E+L+ + G SEETTTGV RL+A+E LR PVIAVNDS MKYLFDNRYGTGQSTW Sbjct: 139 TERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYLFDNRYGTGQSTW 198 Query: 184 DAIMRNTNLLVAGKNVVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGFTVM 243 D IMR TNLLVAGKNVVV GYGWC VIV EVDP+KA+EA MDGF VM Sbjct: 199 DGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKALEARMDGFLVM 258 Query: 244 PMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVEKFE 303 MKEA KI D +TA+GN + +E +KDGA++ANAGHF+VEI LEE+AVE Sbjct: 259 SMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIWKPDLEELAVEISN 318 Query: 304 ARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHRKMS 363 RPNVT Y L++G+ ++LLA+GRLVNL A DGHP EIMD+SFALQ A Y+ ENH ++ Sbjct: 319 PRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQAKAAEYIKENHERLE 378 Query: 364 PKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYLRSWQ 404 P+VY+LP EIDE VAR+KL S+G+ I+ELTE+Q++YL SWQ Sbjct: 379 PRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYLESWQ 419sp|O58275|SAHH_PYRHO ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE) Length = 421 Score = 460 bits (1171), Expect = e-129 Identities = 230/401 (57%), Positives = 287/401 (71%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G KI+WVSR+MP+L I E+ +KP G + ++HLE KTA+L +TL GA+V Sbjct: 18 GWKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLLTLKAGGAEVSAA 77 Query: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIYRENLMKVLDERPDFIIDDGGDLTVISH 123 SNPLSTQDDV AL G+ VYA R + Y E + K LD RP+ IIDDG D+ + H Sbjct: 78 ASNPLSTQDDVVAALAKAGVKVYAIRGESKEQYYEFMHKALDIRPNIIIDDGADMISLVH 137 Query: 124 TEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQSTW 183 ER+E+L+ + G SEETTTGV RL+A+E G LR VIAVNDS MKYLFDNRYGTGQSTW Sbjct: 138 KERQELLDEIWGGSEETTTGVIRLRAMERDGVLRFSVIAVNDSYMKYLFDNRYGTGQSTW 197 Query: 184 DAIMRNTNLLVAGKNVVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGFTVM 243 D +MR TNLL+AGKNVVV GYGWC VIV EVDP+KA+EA MDGF VM Sbjct: 198 DGVMRATNLLIAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKALEARMDGFLVM 257 Query: 244 PMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVEKFE 303 MKEA KI D ITA+G+ + +E +KDGA++ANAGHF+VEI LEE+AVE Sbjct: 258 NMKEAAKIGDIFITATGDIKCIRREHFELMKDGAIMANAGHFDVEIWKPDLEELAVEISN 317 Query: 304 ARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHRKMS 363 RPNVT Y L++G+ ++LLA+GRLVNL A DGHP EIMD+SFALQ A Y+ +NH K+ Sbjct: 318 PRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQAKAAEYIKDNHGKLE 377 Query: 364 PKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYLRSWQ 404 P+VY+LP EIDE VAR+KL S+G++I+ELTE+Q++YL SW+ Sbjct: 378 PRVYILPREIDEMVARIKLASMGIEIEELTEEQKKYLESWE 418dbj|BAA29629| (AP000002) 425aa long hypothetical S-adenosyl-L-homocysteine hydrolase [Pyrococcus horikoshii] Length = 425 Score = 460 bits (1171), Expect = e-129 Identities = 230/401 (57%), Positives = 287/401 (71%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G KI+WVSR+MP+L I E+ +KP G + ++HLE KTA+L +TL GA+V Sbjct: 22 GWKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLLTLKAGGAEVSAA 81 Query: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIYRENLMKVLDERPDFIIDDGGDLTVISH 123 SNPLSTQDDV AL G+ VYA R + Y E + K LD RP+ IIDDG D+ + H Sbjct: 82 ASNPLSTQDDVVAALAKAGVKVYAIRGESKEQYYEFMHKALDIRPNIIIDDGADMISLVH 141 Query: 124 TEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQSTW 183 ER+E+L+ + G SEETTTGV RL+A+E G LR VIAVNDS MKYLFDNRYGTGQSTW Sbjct: 142 KERQELLDEIWGGSEETTTGVIRLRAMERDGVLRFSVIAVNDSYMKYLFDNRYGTGQSTW 201 Query: 184 DAIMRNTNLLVAGKNVVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGFTVM 243 D +MR TNLL+AGKNVVV GYGWC VIV EVDP+KA+EA MDGF VM Sbjct: 202 DGVMRATNLLIAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKALEARMDGFLVM 261 Query: 244 PMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVEKFE 303 MKEA KI D ITA+G+ + +E +KDGA++ANAGHF+VEI LEE+AVE Sbjct: 262 NMKEAAKIGDIFITATGDIKCIRREHFELMKDGAIMANAGHFDVEIWKPDLEELAVEISN 321 Query: 304 ARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHRKMS 363 RPNVT Y L++G+ ++LLA+GRLVNL A DGHP EIMD+SFALQ A Y+ +NH K+ Sbjct: 322 PRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQAKAAEYIKDNHGKLE 381 Query: 364 PKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYLRSWQ 404 P+VY+LP EIDE VAR+KL S+G++I+ELTE+Q++YL SW+ Sbjct: 382 PRVYILPREIDEMVARIKLASMGIEIEELTEEQKKYLESWE 422sp|O28279|SAHH_ARCFU ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE) >gi|2648535 (AE000964) S-adenosylhomocysteinase hydrolase (ahcY-2) [Archaeoglobus fulgidus] Length = 405 Score = 460 bits (1170), Expect = e-128 Identities = 233/401 (58%), Positives = 285/401 (70%), Gaps = 1/401 (0%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G KI W RYM +L KI E++ +E+PL GFTVGM++H+EAKTA L TL GA+V IT Sbjct: 3 GFRKIEWAERYMKVLGKIREQFRKERPLEGFTVGMALHVEAKTAVLVRTLVDAGAEVAIT 62 Query: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIYRENLMKVLDERPDFIIDDGGDLTVISH 123 G NP+STQDDVA+ALR GI YA+R D Y E L V+ PD +IDDG DL + H Sbjct: 63 GCNPMSTQDDVADALRESGIACYAKRGMDVEEYYEALRNVIRAEPDIVIDDGADLIFLLH 122 Query: 124 TEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQSTW 183 E E E +KG SEETTTGV RL+A+E G L+ PVIAVND+ KYLFDNRYGTGQS Sbjct: 123 GEMESYAEKVKGASEETTTGVIRLRAMEREGVLKFPVIAVNDAYTKYLFDNRYGTGQSAI 182 Query: 184 DAIMRNTNLLVAGKNVVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGFTVM 243 D ++R TNLL+AGK VVVAGYGWC V+VTEVD ++A+EA+MDGF VM Sbjct: 183 DGVIRATNLLMAGKIVVVAGYGWCGRGIAMRARGMGASVVVTEVDEIRALEAVMDGFRVM 242 Query: 244 PMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVEKFE 303 M++A KI D ITA+GN D++ +E I +KDGA+LANAGHFNVEI + LE +A K E Sbjct: 243 RMEDAAKIGDIFITATGNRDIIREEHIRLMKDGAILANAGHFNVEIDIPALERMAKAKRE 302 Query: 304 ARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHRKMS 363 AR VT Y L K V+LLAEGRLVNL A DGHPVE+MD+SFA Q A Y+ EN +K+ Sbjct: 303 ARKYVTEYDL-GDKRVYLLAEGRLVNLVAADGHPVEVMDMSFANQALAAKYIAENWQKLE 361 Query: 364 PKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYLRSWQ 404 KVY LP+E+D VARMKL+S+GV+ID+LTE+Q RYL W+ Sbjct: 362 RKVYRLPEELDRMVARMKLESMGVEIDQLTEEQVRYLSDWR 402sp|Q58783|SAHH_METJA ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE) >gi|2144481|pir||C64473 adenosylhomocysteinase (EC 3.3.1.1) - Methanococcus jannaschii >gi|1592034 (U67578) adenosylhomocysteinase (ahcY) [Methanococcus jannaschii] Length = 415 Score = 439 bits (1118), Expect = e-122 Identities = 220/401 (54%), Positives = 284/401 (69%), Gaps = 1/401 (0%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 GE KI W ++MP+LN I E + EKP G T+GM++HLEAKTA LA TL + GA++ IT Sbjct: 13 GERKIQWAKQHMPVLNLIRERFKEEKPFKGITIGMALHLEAKTAVLAETLMEGGAEIAIT 72 Query: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIYRENLMKVLDERPDFIIDDGGDLTVISH 123 G NPLSTQDDVA A KG+ VYA R Y ENL KVLD +PD +IDDG DL + H Sbjct: 73 GCNPLSTQDDVAAACAKKGMHVYAWRGETVEEYYENLNKVLDHKPDIVIDDGCDLIFLLH 132 Query: 124 TEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQSTW 183 T+R E+L+N+ G EETTTG+ RLKA+E+ G L+ PV+ VND+ K+LFDNRYGTGQS Sbjct: 133 TKRTELLDNIMGGCEETTTGIIRLKAMEKEGALKFPVMDVNDAYTKHLFDNRYGTGQSAL 192 Query: 184 DAIMRNTNLLVAGKNVVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGFTVM 243 D I+R TNLL+AGK VVVAGYGWC V+VTEV+P++A+EA MDGF VM Sbjct: 193 DGILRATNLLIAGKTVVVAGYGWCGRGVAMRAKGLGAEVVVTEVNPIRALEARMDGFRVM 252 Query: 244 PMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVEKFE 303 M++A +I D IT +G DV+ KE IL +++GA+LANAGHF+ EI + LEE+A E Sbjct: 253 KMEKAAEIGDIFITTTGCKDVIRKEHILKMRNGAILANAGHFDNEINKKHLEELAKSIKE 312 Query: 304 ARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHRKMS 363 R VT Y L N K ++LL EGRLVNLA DGHP E+MD+SFA Q A Y+L+NH K+ Sbjct: 313 VRNCVTEYDLGN-KKIYLLGEGRLVNLACADGHPCEVMDMSFANQALAAEYILKNHEKLE 371 Query: 364 PKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYLRSWQ 404 P+VY +P E D +A +KL ++G++IDELT++Q++YL W+ Sbjct: 372 PRVYNIPYEQDLMIASLKLKAMGIEIDELTKEQKKYLEDWR 412sp|O27673|SAHH_METTH ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE) >gi|2622763 (AE000922) S-adenosylhomocysteine hydrolase [Methanobacterium thermoautotrophicum] Length = 417 Score = 431 bits (1097), Expect = e-120 Identities = 211/403 (52%), Positives = 281/403 (69%), Gaps = 4/403 (0%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 GE KI WV +MP+L +I ++S EKP G T+G +HLE KT L +TL GA+V +T Sbjct: 14 GEKKIRWVQEHMPVLERIKSDFSEEKPFKGVTIGSCLHLEPKTINLGLTLQAGGAEVAMT 73 Query: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIYRENLMKVLDERPDFIIDDGGDLTVISH 123 G NPLSTQDD A G+ +Y R Y EN+ +VLD P+ +IDDG D+ + H Sbjct: 74 GCNPLSTQDDATAAGAKMGLNMYGWRGETNEEYYENIHRVLDHEPEILIDDGADMIFLVH 133 Query: 124 TEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQSTW 183 ER E+L+ + G EETTTG+ RL+A+ G L+ PV+AVND+ KYLFDNRYGTGQST+ Sbjct: 134 RERPELLDGIIGACEETTTGINRLRAMAADGALKFPVMAVNDAYTKYLFDNRYGTGQSTF 193 Query: 184 DAIMRNTNLLVAGKNVVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGFTVM 243 D+IM TN+L+AGK VVV GYGWC VIVTEVDP++A+EA MDGF VM Sbjct: 194 DSIMGTTNMLIAGKTVVVCGYGWCGRGIAMRAEGLGASVIVTEVDPIRALEARMDGFRVM 253 Query: 244 PMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVEKFE 303 + +AVK AD +ITA+GNTDV+S+ + +++KDG V+AN+GHFNVEI LEE++ E + Sbjct: 254 KVSDAVKEADILITATGNTDVVSESEFMNMKDGCVMANSGHFNVEINREALEELSRETGK 313 Query: 304 ARPNVTGYTLENGKTVFLLAEGRLVNLAA--GDGHPVEIMDLSFALQIFAVLYLLENHRK 361 + ++ + + +G+ ++LLAEGRLVNLA+ G GHP EIMD+SFA+Q + +LL+ K Sbjct: 314 VKEDIEVFIMPDGRKIYLLAEGRLVNLASERGQGHPAEIMDMSFAMQALSARHLLQ--EK 371 Query: 362 MSPKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYLRSWQ 404 P VY PDEID VARMKLD++G++IDELTEKQR YL +W+ Sbjct: 372 PDPGVYRAPDEIDLMVARMKLDAMGIEIDELTEKQRLYLENWE 414sp|O67240|SAHH_AQUAE ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE) >gi|2983629 (AE000727) S-adenosylhomocysteine hydrolase [Aquifex aeolicus] Length = 418 Score = 420 bits (1069), Expect = e-117 Identities = 210/402 (52%), Positives = 281/402 (69%), Gaps = 1/402 (0%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G +I W MP+L +I E +S+EKPL G + +H+ +TA L TL + GA+V +T Sbjct: 14 GLKRIEWAEMDMPVLRQIRERFSKEKPLKGKKISACLHVTTETANLMRTLKEGGAEVYLT 73 Query: 64 GSNPLSTQDDVAEAL-RSKGITVYARRTHDESIYRENLMKVLDERPDFIIDDGGDLTVIS 122 SNPLSTQDDVA AL + I V+A R D Y ++L V+++ PD +IDDG DL Sbjct: 74 ASNPLSTQDDVAAALVKYFEIPVFAIRGEDRETYYKHLRAVIEKEPDVVIDDGADLISTL 133 Query: 123 HTEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQST 182 H E + E + G EETTTGV RL+A+ E G L+ P+IAVND+ K++FDNRYGTGQST Sbjct: 134 HKEYPGLAEKVLGGMEETTTGVIRLRAMAEQGVLKFPIIAVNDAYTKHMFDNRYGTGQST 193 Query: 183 WDAIMRNTNLLVAGKNVVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGFTV 242 D I+R TN L+AG VVAGYGWC VIVTEVDP+KA+EA MDGF V Sbjct: 194 IDGILRATNRLLAGSYFVVAGYGWCGKGVAQRARGMGAIVIVTEVDPIKALEARMDGFLV 253 Query: 243 MPMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVEKF 302 MPM+EA K+ DF +T +GN V+ +E +KDGA++AN+GHFNVEI + LEE+AVEK Sbjct: 254 MPMEEAAKLGDFFVTVTGNIHVIRREHFEVMKDGAIVANSGHFNVEIDIPALEEMAVEKR 313 Query: 303 EARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHRKM 362 E R VT Y L++G+ ++LLAEGRLVNLAA +GHP +MD+SF+ Q + Y++++H+++ Sbjct: 314 EIRKEVTEYKLKDGRRIYLLAEGRLVNLAAAEGHPASVMDMSFSNQALSAEYIVKHHKEL 373 Query: 363 SPKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYLRSWQ 404 KVY +P EIDE VAR+KL++LG+KIDELTE+Q++YL SW+ Sbjct: 374 EKKVYRVPREIDEAVARLKLNALGIKIDELTEEQKKYLSSWE 415emb|CAB57547.1| (Y18930) s-adenosylhomocysteine hydrolase [Sulfolobus solfataricus] Length = 442 Score = 408 bits (1038), Expect = e-113 Identities = 206/402 (51%), Positives = 278/402 (68%), Gaps = 2/402 (0%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G+ +I W R+MP L +I + + EKPL G + +H+ +TA L TL GA V + Sbjct: 39 GKKQIEWAERHMPTLMEIRKRFKAEKPLKGINISAVLHVTKETAALVKTLKIGGANVALA 98 Query: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIYRENLMKVLD-ERPDFIIDDGGDLTVIS 122 GSNPLSTQDDVA AL +GI+V+A + +E+ Y N+ ++ P+ ++DDG DL Sbjct: 99 GSNPLSTQDDVAAALVEEGISVFAWKGENETEYYSNIESIVKIHEPNIVMDDGADLHAYI 158 Query: 123 HTEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQST 182 H + L+ + G +EETTTGV RLKA+E+ G L+ P++AVN++ KYLFDNRYGTGQS Sbjct: 159 HEKVSSKLD-IYGGTEETTTGVIRLKAMEKDGVLKYPLVAVNNAYTKYLFDNRYGTGQSA 217 Query: 183 WDAIMRNTNLLVAGKNVVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGFTV 242 D I+R TN+L+AGK VVAGYGW VIVTEVDP++A+EA+MDGF V Sbjct: 218 IDGILRATNILIAGKIAVVAGYGWVGRGIANRLRGMGARVIVTEVDPIRALEAVMDGFDV 277 Query: 243 MPMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVEKF 302 MP+ EA K+ D +TA+GNT + E +L++KDGA+L+NAGHFNVE+ V+ L+E AV+ Sbjct: 278 MPIAEASKVGDIFVTATGNTKAIRVEHMLNMKDGAILSNAGHFNVEVDVKGLKETAVKVR 337 Query: 303 EARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHRKM 362 RP V YTL NGK V+LLA+GRLVNLAA +GHP E+MD+SFA Q AV YL++N K+ Sbjct: 338 NIRPYVDEYTLPNGKRVYLLADGRLVNLAAAEGHPSEVMDMSFANQALAVEYLVKNRGKL 397 Query: 363 SPKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYLRSWQ 404 KVY +P E+D VAR+KL S+G++IDELTE+Q+ YL W+ Sbjct: 398 EKKVYNMPMELDYEVARIKLKSMGIQIDELTEEQKEYLEQWK 439sp|P50252|SAHH_SULSO ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE) >gi|2118058|pir||S58193 adenosylhomocysteinase (EC 3.3.1.1) - Sulfolobus solfataricus >gi|2129448|pir||JC5156 S-adenosylhomocysteine hydrolase (EC 3.-.-.-) - Sulfolobus solfataricus >gi|927551|emb|CAA90536| (Z50174) S-adenosylhomocysteine hydrolase [Sulfolobus solfataricus] Length = 417 Score = 408 bits (1038), Expect = e-113 Identities = 206/402 (51%), Positives = 278/402 (68%), Gaps = 2/402 (0%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G+ +I W R+MP L +I + + EKPL G + +H+ +TA L TL GA V + Sbjct: 14 GKKQIEWAERHMPTLMEIRKRFKAEKPLKGINISAVLHVTKETAALVKTLKIGGANVALA 73 Query: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIYRENLMKVLD-ERPDFIIDDGGDLTVIS 122 GSNPLSTQDDVA AL +GI+V+A + +E+ Y N+ ++ P+ ++DDG DL Sbjct: 74 GSNPLSTQDDVAAALVEEGISVFAWKGENETEYYSNIESIVKIHEPNIVMDDGADLHAYI 133 Query: 123 HTEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQST 182 H + L+ + G +EETTTGV RLKA+E+ G L+ P++AVN++ KYLFDNRYGTGQS Sbjct: 134 HEKVSSKLD-IYGGTEETTTGVIRLKAMEKDGVLKYPLVAVNNAYTKYLFDNRYGTGQSA 192 Query: 183 WDAIMRNTNLLVAGKNVVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGFTV 242 D I+R TN+L+AGK VVAGYGW VIVTEVDP++A+EA+MDGF V Sbjct: 193 IDGILRATNILIAGKIAVVAGYGWVGRGIANRLRGMGARVIVTEVDPIRALEAVMDGFDV 252 Query: 243 MPMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVEKF 302 MP+ EA K+ D +TA+GNT + E +L++KDGA+L+NAGHFNVE+ V+ L+E AV+ Sbjct: 253 MPIAEASKVGDIFVTATGNTKAIRVEHMLNMKDGAILSNAGHFNVEVDVKGLKETAVKVR 312 Query: 303 EARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHRKM 362 RP V YTL NGK V+LLA+GRLVNLAA +GHP E+MD+SFA Q AV YL++N K+ Sbjct: 313 NIRPYVDEYTLPNGKRVYLLADGRLVNLAAAEGHPSEVMDMSFANQALAVEYLVKNRGKL 372 Query: 363 SPKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYLRSWQ 404 KVY +P E+D VAR+KL S+G++IDELTE+Q+ YL W+ Sbjct: 373 EKKVYNMPMELDYEVARIKLKSMGIQIDELTEEQKEYLEQWK 414dbj|BAA79594.1| (AP000060) 399aa long hypothetical adenosylhomocysteinase [Aeropyrum pernix] Length = 399 Score = 385 bits (979), Expect = e-106 Identities = 198/399 (49%), Positives = 262/399 (65%) Query: 6 MKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVITGS 65 M+I W R+MP+L ++ +KPLSG V +H+ +TA L TL K GA+V + S Sbjct: 1 MQIEWAERHMPVLMRLRSSMGGDKPLSGVRVAACLHVTKETAVLVETLRKWGAEVYLAPS 60 Query: 66 NPLSTQDDVAEALRSKGITVYARRTHDESIYRENLMKVLDERPDFIIDDGGDLTVISHTE 125 NPLSTQD+VA AL GI V+A R Y+ L V PD +IDDG DL V+ H E Sbjct: 61 NPLSTQDEVAAALAEAGIGVFAWRGMTPEEYKWALSTVAGREPDIVIDDGADLHVLLHEE 120 Query: 126 REEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQSTWDA 185 V E + G +EETTTGV RL+ALE G+L PVIAVND+ K++FDNRYGTGQST D Sbjct: 121 MRSVGEKVWGGTEETTTGVIRLRALEREGRLLYPVIAVNDALTKFMFDNRYGTGQSTVDG 180 Query: 186 IMRNTNLLVAGKNVVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGFTVMPM 245 ++R TN+L+AGK VVVAGYGW V+VTEVDPV+A+EA MDGFTV M Sbjct: 181 VLRATNILIAGKTVVVAGYGWVGRGIAARFRGMGAKVVVTEVDPVRALEAAMDGFTVTTM 240 Query: 246 KEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVEKFEAR 305 EA + D ITA+GN +V+ + +KDGA+LANAGHFNVEI V LEE++V K R Sbjct: 241 DEAASLGDVFITATGNINVIDARHMEKMKDGAILANAGHFNVEINVAALEEMSVSKRRVR 300 Query: 306 PNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHRKMSPK 365 + Y L +G+ ++L+ EGRLVNL A +GHP E+MD+SF+ Q AVL + ++ + Sbjct: 301 RYLDEYRLPDGRRLYLIGEGRLVNLVAAEGHPSEVMDMSFSNQALAVLKIAGERGRLEKR 360 Query: 366 VYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYLRSWQ 404 V+ + DE VAR+KL+++GV+ID LTE+Q+ YL+ W+ Sbjct: 361 VHRVERIQDEMVARLKLETMGVRIDSLTEEQKLYLQKWK 399sp|P74008|SAHH_SYNY3 ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE) >gi|1653163|dbj|BAA18079| (D90911) S-adenosylhomocysteine hydrolase [Synechocystis sp.] Length = 425 Score = 367 bits (933), Expect = e-101 Identities = 184/401 (45%), Positives = 255/401 (62%), Gaps = 1/401 (0%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G +I W +R MP+L +I E +++EKP +G + H+ +TA LAI L GA ++ Sbjct: 21 GRQRIEWAAREMPVLKQIRERFAQEKPFAGIRLVACCHVTTETANLAIALHAGGADSLLI 80 Query: 64 GSNPLSTQDDVAEALRSK-GITVYARRTHDESIYRENLMKVLDERPDFIIDDGGDLTVIS 122 SNPLSTQDDVA L + GI VYA + D Y ++ LD RP+ IIDDG D+ Sbjct: 81 ASNPLSTQDDVAACLVADYGIPVYAIKGEDNETYHRHVQIALDHRPNIIIDDGSDVVATL 140 Query: 123 HTEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQST 182 ER+ L ++ G +EETTTG+ RL+A+ G L P + VND+ K+ +DNRYGTGQST Sbjct: 141 VQERQHQLSDIIGTTEETTTGIVRLRAMFNDGVLTFPAMNVNDADTKHFYDNRYGTGQST 200 Query: 183 WDAIMRNTNLLVAGKNVVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGFTV 242 D I+R TN+L+AGK +VVAGYGWC VIVTE+ PV A+EA MDGF V Sbjct: 201 LDGIIRATNILLAGKTIVVAGYGWCGKGVAMRAKGMGADVIVTEISPVPAIEAAMDGFRV 260 Query: 243 MPMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVEKF 302 MPM EA D IT +GN V+ E +KDGA++ N+GHF++EI ++ L+E A E Sbjct: 261 MPMAEAAHQGDIFITVTGNKHVIRPEHFAVMKDGAIVCNSGHFDIEIDLKSLKEQAKEVK 320 Query: 303 EARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHRKM 362 E R Y L NGK++ ++ EGRLVNLAA +GHP +MD+SFA Q A +L++N ++ Sbjct: 321 EVRNFTEQYILPNGKSIIVIGEGRLVNLAAAEGHPSAVMDMSFANQALACEHLVKNKGQL 380 Query: 363 SPKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYLRSW 403 P ++ +P E+D+ +AR+KL ++G+ ID LT +Q Y+ SW Sbjct: 381 EPGMHSIPVEVDQEIARLKLQAMGIAIDSLTPEQVEYINSW 421sp|O93477|SAH2_XENLA ADENOSYLHOMOCYSTEINASE 2 (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE 2) (ADOHCYASE 2) >gi|3413509|emb|CAA07706| (AJ007835) S-adenosyl-L-homocysteine hydrolase [Xenopus laevis] Length = 433 Score = 298 bits (756), Expect = 4e-80 Identities = 166/401 (41%), Positives = 236/401 (58%), Gaps = 4/401 (0%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G I MP L K+ E YS KPL G + +H+ +TA L TL+ +GA+V + Sbjct: 18 GRKAIEIAENEMPGLMKMREMYSESKPLKGARIAGCLHMTLQTAVLIETLTAIGAEVQWS 77 Query: 64 GSNPLSTQDDVAEALRSKGITVYARR--THDESIYR-ENLMKVLDERP-DFIIDDGGDLT 119 N STQD A A+ G+ VYA + T +E I+ E + D +P + I+DDGGDLT Sbjct: 78 SCNIFSTQDHAAAAIAKTGVPVYAWKGETDEEYIWCIEQTIYFKDGKPLNMILDDGGDLT 137 Query: 120 VISHTEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTG 179 + HT+ ++L+ +KG+SEETTTGV L ++ +G L+VP I VNDS K FDN YG Sbjct: 138 NLVHTKYPQLLKGIKGISEETTTGVHNLYKMKSSGTLQVPAINVNDSVTKSKFDNLYGCR 197 Query: 180 QSTWDAIMRNTNLLVAGKNVVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDG 239 +S D I R T++++AGK VVAGYG V++TE+DP+ A++A M+G Sbjct: 198 ESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRAFGARVLITEIDPINALQAAMEG 257 Query: 240 FTVMPMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAV 299 + V M EA K + +T +G D++ ++KD +++ N GHF+VE+ V+ L + A Sbjct: 258 YEVTTMDEASKEGNIFVTTTGCADIVEGRHFENMKDDSIVCNIGHFDVELDVKWLNDNAA 317 Query: 300 EKFEARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENH 359 +K +P V Y L+NG+ + LLAEGRLVNL GHP +M SF Q+ A + L N Sbjct: 318 KKINIKPQVDRYLLKNGRHIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTNT 377 Query: 360 RKMSPKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYL 400 K VY LP ++DE VA LD LGVK+ +LT+KQ +YL Sbjct: 378 DKYPVGVYFLPKKLDEAVAAAHLDKLGVKLTKLTDKQAKYL 418sp|P51893|SAH1_XENLA ADENOSYLHOMOCYSTEINASE 1 (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE 1) (ADOHCYASE 1) >gi|1079279|pir||JC2480 adenosylhomocysteinase (EC 3.3.1.1) - African clawed frog >gi|558508 (L35559) adenine homocysteine hydrolase [Xenopus laevis] Length = 433 Score = 298 bits (756), Expect = 4e-80 Identities = 167/401 (41%), Positives = 237/401 (58%), Gaps = 4/401 (0%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G I MP L K+ E +S KPL G + +H+ +TA L TL+ LGA+V + Sbjct: 18 GRKAIEIAENEMPGLMKMREMHSESKPLKGARIAGCLHMTLQTAVLIETLTALGAEVQWS 77 Query: 64 GSNPLSTQDDVAEALRSKGITVYARR--THDESIYR-ENLMKVLDERP-DFIIDDGGDLT 119 N STQD A A+ G+ VYA + T +E I+ E + D +P + I+DDGGDLT Sbjct: 78 SCNIFSTQDHAAAAIAKTGVPVYAWKGETDEEYIWCIEQTIYFKDGKPLNMILDDGGDLT 137 Query: 120 VISHTEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTG 179 + H++ ++L+ +KG+SEETTTGV L ++ +G L+VP I VNDS K FDN YG Sbjct: 138 NLVHSKYPQLLKGIKGISEETTTGVHNLYKMKSSGTLQVPAINVNDSVTKSKFDNLYGCR 197 Query: 180 QSTWDAIMRNTNLLVAGKNVVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDG 239 +S D I R T++++AGK VVAGYG VI+TE+DP+ A++A M+G Sbjct: 198 ESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRAFGARVIITEIDPINALQAAMEG 257 Query: 240 FTVMPMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAV 299 + V M EA K + +T +G D++ ++KD +++ N GHF++E+ V+ L E AV Sbjct: 258 YEVTTMDEASKEGNIFVTTTGCADIVEGRHFENMKDDSIVCNIGHFDIELDVKWLNENAV 317 Query: 300 EKFEARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENH 359 +K +P V Y L+NG+ + LLAEGRLVNL GHP +M SF Q+ A + L N Sbjct: 318 KKVNIKPQVDRYLLKNGRHIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTNT 377 Query: 360 RKMSPKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYL 400 K VY LP ++DE VA LD LGVK+ +LT+KQ +YL Sbjct: 378 DKYPVGVYFLPKKLDEAVAAAHLDKLGVKLTKLTDKQAKYL 418pir||A43629 adenosylhomocysteinase (EC 3.3.1.1) - human >gi|178279 (M61832) S-adenosylhomocysteine hydrolase [Homo sapiens] Length = 432 Score = 289 bits (733), Expect = 2e-77 Identities = 164/400 (41%), Positives = 226/400 (56%), Gaps = 3/400 (0%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G ++ MP L ++ E YS KPL G + +H+ +TA L TL LGA+V + Sbjct: 18 GRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWS 77 Query: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIYR---ENLMKVLDERPDFIIDDGGDLTV 120 N STQD A A+ GI VYA + + Y E + D + I+DDGGDLT Sbjct: 78 SCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLNMILDDGGDLTN 137 Query: 121 ISHTEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQ 180 + HT+ ++L ++G+SEETTTGV L + G L+VP I VNDS K FDN YG + Sbjct: 138 LIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRE 197 Query: 181 STWDAIMRNTNLLVAGKNVVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGF 240 S D I R T++++AGK VVAGYG VI+TE+DP+ A++A M+G+ Sbjct: 198 SLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGY 257 Query: 241 TVMPMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVE 300 V M EA + + +T +G D++ +KD A++ N GHF+VEI V+ L E AVE Sbjct: 258 EVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVE 317 Query: 301 KFEARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHR 360 K +P V Y L+NG+ + LLAEGRLVNL GHP +M SF Q+ A + L + Sbjct: 318 KVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPD 377 Query: 361 KMSPKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYL 400 K V+ LP ++DE VA L L VK+ +LTEKQ +YL Sbjct: 378 KYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYL 417pdb|1B3R|A Chain A, Rat Liver S-Adenosylhomocystein Hydrolase Author List: Fusao Takusagawa Functional Class: Hydrolase Metabolic Role: Adohcy To Ado And Hcy Known Biological Or Chemical Activity: Major Regulatory Enzyme Of Adomet-Dependent ... >gi|4139572|pdb|1B3R|B Chain B, Rat Liver S-Adenosylhomocystein Hydrolase Author List: Fusao Takusagawa Functional Class: Hydrolase Metabolic Role: Adohcy To Ado And Hcy Known Biological Or Chemical Activity: Major Regulatory Enzyme Of Adomet-Dependent ... >gi|4139573|pdb|1B3R|C Chain C, Rat Liver S-Adenosylhomocystein Hydrolase Author List: Fusao Takusagawa Functional Class: Hydrolase Metabolic Role: Adohcy To Ado And Hcy Known Biological Or Chemical Activity: Major Regulatory Enzyme Of Adomet-Dependent ... >gi|4139574|pdb|1B3R|D Chain D, Rat Liver S-Adenosylhomocystein Hydrolase Author List: Fusao Takusagawa Functional Class: Hydrolase Metabolic Role: Adohcy To Ado And Hcy Known Biological Or Chemical Activity: Major Regulatory Enzyme Of Adomet-Dependent ... Length = 431 Score = 289 bits (732), Expect = 3e-77 Identities = 164/400 (41%), Positives = 225/400 (56%), Gaps = 3/400 (0%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G ++ MP L ++ E YS KPL G + +H+ +TA L TL LGA+V + Sbjct: 17 GRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWS 76 Query: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIYR---ENLMKVLDERPDFIIDDGGDLTV 120 N STQD A A+ GI V+A + + Y E + D + I+DDGGDLT Sbjct: 77 SCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTN 136 Query: 121 ISHTEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQ 180 + HT+ ++L ++G+SEETTTGV L + G L+VP I VNDS K FDN YG + Sbjct: 137 LIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRE 196 Query: 181 STWDAIMRNTNLLVAGKNVVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGF 240 S D I R T++++AGK VVAGYG VI+TE+DP+ A++A M+G+ Sbjct: 197 SLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGY 256 Query: 241 TVMPMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVE 300 V M EA K + +T +G D++ +KD A++ N GHF+VEI V+ L E AVE Sbjct: 257 EVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVE 316 Query: 301 KFEARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHR 360 K +P V Y L+NG + LLAEGRLVNL GHP +M SF Q+ A + L + Sbjct: 317 KVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPD 376 Query: 361 KMSPKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYL 400 K V+ LP ++DE VA L L VK+ +LTEKQ +YL Sbjct: 377 KYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYL 416sp|P10760|SAHH_RAT ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE) >gi|91925|pir||A26583 adenosylhomocysteinase (EC 3.3.1.1) - rat >gi|202804 (M15185) S-adenosyl-L-homocysteine hydrolase (EC 3.3.1.1) [Rattus sp.] >gi|1185363 (U14937) S-adenosyl-L-homocysteine hydrolase [Rattus norvegicus] Length = 432 Score = 289 bits (732), Expect = 3e-77 Identities = 164/400 (41%), Positives = 225/400 (56%), Gaps = 3/400 (0%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G ++ MP L ++ E YS KPL G + +H+ +TA L TL LGA+V + Sbjct: 18 GRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWS 77 Query: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIYR---ENLMKVLDERPDFIIDDGGDLTV 120 N STQD A A+ GI V+A + + Y E + D + I+DDGGDLT Sbjct: 78 SCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTN 137 Query: 121 ISHTEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQ 180 + HT+ ++L ++G+SEETTTGV L + G L+VP I VNDS K FDN YG + Sbjct: 138 LIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRE 197 Query: 181 STWDAIMRNTNLLVAGKNVVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGF 240 S D I R T++++AGK VVAGYG VI+TE+DP+ A++A M+G+ Sbjct: 198 SLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGY 257 Query: 241 TVMPMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVE 300 V M EA K + +T +G D++ +KD A++ N GHF+VEI V+ L E AVE Sbjct: 258 EVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVE 317 Query: 301 KFEARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHR 360 K +P V Y L+NG + LLAEGRLVNL GHP +M SF Q+ A + L + Sbjct: 318 KVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPD 377 Query: 361 KMSPKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYL 400 K V+ LP ++DE VA L L VK+ +LTEKQ +YL Sbjct: 378 KYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYL 417sp|P50247|SAHH_MOUSE ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE) (LIVER COPPER BINDING PROTEIN) (CUBP) >gi|904132 (L32836) copper binding protein [Mus musculus] Length = 432 Score = 289 bits (731), Expect = 3e-77 Identities = 164/400 (41%), Positives = 225/400 (56%), Gaps = 3/400 (0%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G ++ MP L ++ E YS KPL G + +H+ +TA L TL LGA+V + Sbjct: 18 GRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWS 77 Query: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIYR---ENLMKVLDERPDFIIDDGGDLTV 120 N STQD A A+ GI V+A + + Y E + D + I+DDGGDLT Sbjct: 78 SCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTN 137 Query: 121 ISHTEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQ 180 + HT+ ++L ++G+SEETTTGV L + G L VP I VNDS K FDN YG + Sbjct: 138 LIHTKYPQLLSGIRGISEETTTGVHNLYKMMSNGILNVPAINVNDSVTKSKFDNLYGCRE 197 Query: 181 STWDAIMRNTNLLVAGKNVVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGF 240 S D I R T++++AGK VVAGYG VI+TE+DP+ A++A M+G+ Sbjct: 198 SLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGY 257 Query: 241 TVMPMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVE 300 V M EA K + +T +G D++ +KD A++ N GHF+VEI V+ L E AVE Sbjct: 258 EVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVE 317 Query: 301 KFEARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHR 360 K +P V Y L+NG+ + LLAEGRLVNL GHP +M SF Q+ A + L + Sbjct: 318 KVNIKPQVDRYWLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPD 377 Query: 361 KMSPKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYL 400 K V+ LP ++DE VA L L VK+ +LTEKQ +YL Sbjct: 378 KYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYL 417sp|P23526|SAHH_HUMAN ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE) >gi|178277 (M61831) S-adenosylhomocysteine hydrolase [Homo sapiens] Length = 432 Score = 287 bits (728), Expect = 8e-77 Identities = 163/400 (40%), Positives = 226/400 (55%), Gaps = 3/400 (0%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G ++ MP L ++ E YS KPL G + +H+ +TA L TL LGA+V + Sbjct: 18 GRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWS 77 Query: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIYR---ENLMKVLDERPDFIIDDGGDLTV 120 N STQ+ A A+ GI VYA + + Y E + D + I+DDGGDLT Sbjct: 78 SCNIFSTQNHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLNMILDDGGDLTN 137 Query: 121 ISHTEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQ 180 + HT+ ++L ++G+SEETTTGV L + G L+VP I VNDS K FDN YG + Sbjct: 138 LIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRE 197 Query: 181 STWDAIMRNTNLLVAGKNVVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGF 240 S D I R T++++AGK VVAGYG VI+TE+DP+ A++A M+G+ Sbjct: 198 SLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGY 257 Query: 241 TVMPMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVE 300 V M EA + + +T +G D++ +KD A++ N GHF+VEI V+ L E AVE Sbjct: 258 EVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVE 317 Query: 301 KFEARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHR 360 K +P V Y L+NG+ + LLAEGRLVNL GHP +M SF Q+ A + L + Sbjct: 318 KVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPD 377 Query: 361 KMSPKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYL 400 K V+ LP ++DE VA L L VK+ +LTEKQ +YL Sbjct: 378 KYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYL 417sp|O13639|SAHH_SCHPO ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE) >gi|2257533|dbj|BAA21427| (AB004537) ADENOSYL HOMOCYS TEINASE [Schizosaccharomyces pombe] >gi|2950505|emb|CAA17833.1| (AL022072) adenosylhomocysteinase [Schizosaccharomyces pombe] Length = 433 Score = 284 bits (718), Expect = 1e-75 Identities = 159/402 (39%), Positives = 228/402 (56%), Gaps = 5/402 (1%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G ++ MP L + E+Y++ +PL G + +H+ +TA L TL LGA+V + Sbjct: 17 GRKELEIAENEMPGLIAVREKYAKSQPLKGARIAGCLHMTIQTAVLIETLVALGAEVTWS 76 Query: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIYRENLMKVLDERP-----DFIIDDGGDL 118 N STQD A A+ + G+ V+A + E Y + + L P + I+DDGGDL Sbjct: 77 SCNIYSTQDHAAAAIAATGVPVFAWKGETEEEYLWCIEQQLKSFPSGKPLNMILDDGGDL 136 Query: 119 TVISHTEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGT 178 T + H E+L +++G+SEETTTGV L + + KL+VP I VNDS K FDN +G Sbjct: 137 TALVHERHPELLVDIRGISEETTTGVHNLYKMFKENKLKVPAINVNDSVTKSKFDNLFGC 196 Query: 179 GQSTWDAIMRNTNLLVAGKNVVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMD 238 +S D I R T++++AGK VVAG+G VIVTEVDP+ A++A MD Sbjct: 197 KESLVDGIKRATDVMIAGKVAVVAGFGDVGKGCSTSLRSQGARVIVTEVDPINALQAAMD 256 Query: 239 GFTVMPMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIA 298 GF V M+EAVK +T +G D++ E +K+ +++ N GHF+VEI V L+ A Sbjct: 257 GFEVTTMEEAVKEGQIFVTTTGCRDIIRGEHFNEMKEDSIVCNIGHFDVEIDVAWLKANA 316 Query: 299 VEKFEARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLEN 358 + +P V Y L+NG+ + LLA+GRLVNL GHP +M SF Q+ A + L + Sbjct: 317 KDVVNIKPQVDRYELKNGRHIILLADGRLVNLGCATGHPSFVMSCSFTNQVLAQIALWTD 376 Query: 359 HRKMSPKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYL 400 + V+MLP ++DE VAR+ L LGVK+ LT Q YL Sbjct: 377 NTSYPLGVHMLPKKLDEEVARLHLGKLGVKLTTLTSVQSDYL 418sp|O76757|SAHH_ANOGA ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE) >gi|3406737 (AF080546) S-adenosyl-L-homocysteine hydrolase [Anopheles gambiae] Length = 432 Score = 281 bits (711), Expect = 8e-75 Identities = 161/401 (40%), Positives = 230/401 (57%), Gaps = 4/401 (0%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G +I MP L ++Y K L G + +H+ +TA L TL +LGA+V + Sbjct: 17 GRKEIVLAENEMPGLMACRQKYGPLKILRGARIAGCLHMTIQTAVLIETLIELGAEVQWS 76 Query: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIYRENLMKVL---DERP-DFIIDDGGDLT 119 N STQD A A+ G+ VYA + + Y + + L D +P + I+DDGGDLT Sbjct: 77 SCNIFSTQDHAAAAMVKAGVPVYAWKGETDEEYMWCIRQTLIFPDGKPLNMILDDGGDLT 136 Query: 120 VISHTEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTG 179 + H E E+L+ ++G+SEETTTGV L + G+L +P I VNDS K FDN YG Sbjct: 137 NLVHAEHPELLKEIRGLSEETTTGVHNLYKMFREGRLGMPAINVNDSVTKSKFDNLYGCR 196 Query: 180 QSTWDAIMRNTNLLVAGKNVVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDG 239 +S D I R T++++AGK VVAGYG V++TE+DP+ A++A M+G Sbjct: 197 ESLLDGIKRATDVMIAGKVCVVAGYGDVGKGCAQALRGSGGRVLITEIDPINALQAAMEG 256 Query: 240 FTVMPMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAV 299 V M+EA K A +T +G TD++ E L++KD +++ N GHF+ EI V L+E AV Sbjct: 257 KEVTTMEEASKEAQIFVTTTGCTDIIMGEHFLNMKDDSIVCNIGHFDCEINVTWLQENAV 316 Query: 300 EKFEARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENH 359 EK +P V Y L NG + LLAEGRLVNL GH +M SF Q+ A + L N Sbjct: 317 EKVNIKPQVDRYRLANGNHIILLAEGRLVNLGCAMGHSSFVMSNSFTNQVLAQIELWTNR 376 Query: 360 RKMSPKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYL 400 + + V++LP ++D+ VA + LD LGVK+ +L+ +Q YL Sbjct: 377 EQYAIGVHVLPKKLDDEVAALHLDKLGVKLTKLSARQPEYL 417sp|Q27580|SAHH_DROME ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE) >gi|1200230|emb|CAA64892| (X95636) S-adenosyl-L-homocysteine hydrolase [Drosophila melanogaster] Length = 431 Score = 281 bits (711), Expect = 8e-75 Identities = 162/390 (41%), Positives = 227/390 (57%), Gaps = 5/390 (1%) Query: 15 MPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVITGSNPLSTQDDV 74 MP L ++Y KPL G + +H+ +TA L TL +LGA+V + N STQD+ Sbjct: 28 MPGLMACRKKYGPSKPLKGARITGCLHMTVQTAVLIETLVELGAQVQWSSCNIFSTQDNA 87 Query: 75 AEALRSKGITVYARRTHDESIYR---ENLMKVLDERP-DFIIDDGGDLTVISHTEREEVL 130 A A+ + G+ VYA + + Y E + D +P + I+DDGGDLT + H + + L Sbjct: 88 AAAIAATGVPVYAWKGETDEEYMWCIEQTLVFPDGQPLNMILDDGGDLTNLVHEKFPQFL 147 Query: 131 ENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQSTWDAIMRNT 190 +N+KG+SEETTTGV L + + G+L VP I VNDS K FDN YG +S D I R T Sbjct: 148 KNIKGLSEETTTGVHNLYKMFKEGRLGVPAINVNDSVTKSKFDNLYGCRESLIDGIKRAT 207 Query: 191 NLLVAGKNVVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGFTVMPMKEAVK 250 ++++AGK VAGYG VIVTEVDP+ A++A M+G+ V M+E K Sbjct: 208 DVMIAGKVCCVAGYGDVGKGCAQALKGFGGRVIVTEVDPINALQAAMEGYEVTTMEEGSK 267 Query: 251 IADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVEKFEARPNVTG 310 A +T +G D+++ + + D ++ N GHF++EI V L A EK +P V Sbjct: 268 EASIFVTTTGCRDIITSVHLQQMPDDRIVCNIGHFDIEIDVDWLNANAKEKVNVKPQVDR 327 Query: 311 YTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHRKMSPKVYMLP 370 YT+++GK + LLAEGRLVNL DGHP +M SF Q+ A + L K S V++LP Sbjct: 328 YTMKSGKHIILLAEGRLVNLGCADGHPSFVMSNSFTNQVLAQIELWTKSDK-SVGVHVLP 386 Query: 371 DEIDERVARMKLDSLGVKIDELTEKQRRYL 400 +DE VA + L+ LGVK+ +LTEKQ YL Sbjct: 387 KILDEEVASLHLEKLGVKLTKLTEKQATYL 416sp|P10819|SAHH_DICDI ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE) >gi|84087|pir||A27655 adenosylhomocysteinase (EC 3.3.1.1) - slime mold (Dictyostelium discoideum) >gi|167664 (M19937) S-adenosyl-L-homocysteine hydrolase [Dictyostelium discoideum] Length = 430 Score = 277 bits (701), Expect = 1e-73 Identities = 159/400 (39%), Positives = 224/400 (55%), Gaps = 4/400 (1%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G +I + MP L + ++Y + L G + +H+ +TA L TL+ LGA+V + Sbjct: 17 GRKEIEIAANEMPGLMTLRKKYGPAQILKGARIAGCLHMTIQTAVLIETLTALGAQVQWS 76 Query: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIYR---ENLMKVLDERPDFIIDDGGDLTV 120 N STQD A A+ + G+ VYA + E Y E + D + I+DDGGDLT Sbjct: 77 SCNIFSTQDQAAAAIAATGVPVYAWKGETEEEYNWCVEQTIVFQDGPLNMILDDGGDLTT 136 Query: 121 ISHTEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQ 180 + H + + L +KG+SEETT GV L + + GKL+VP I VNDS K FDN YG + Sbjct: 137 LVHEKYPQFLAGIKGISEETTHGVHNLYKMFKEGKLKVPAINVNDSVTKSKFDNLYGCRE 196 Query: 181 STWDAIMRNTNLLVAGKNVVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGF 240 S D I R T++++AGK VVAGYG V+VTE+DP+ A++A MDG+ Sbjct: 197 SLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQSLSKMGARVLVTEIDPINALQACMDGY 256 Query: 241 TVMPMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVE 300 ++ M+ A +++ +T +G D++ E +K+ A++ N GHF+ EI V L A + Sbjct: 257 QIVTMETAAPLSNIFVTTTGCRDIVRGEHFAVMKEDAIVCNIGHFDCEIDVAWLNANA-K 315 Query: 301 KFEARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHR 360 K +P V YTL NG + LLAEGRLVNL G GHP +M SF Q A + L Sbjct: 316 KDTVKPQVDRYTLANGVHIILLAEGRLVNLGCGTGHPSFVMSNSFCNQTLAQIALWTKTE 375 Query: 361 KMSPKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYL 400 + V++LP +DE VAR+ LD LG K+ LTEKQ YL Sbjct: 376 EYPLGVHLLPKILDEEVARLHLDQLGAKLTTLTEKQSEYL 415pdb|1A7A|A Chain A, Structure Of Human Placental S-Adenosylhomocysteine Hydrolase: Determination Of A 30 Selenium Atom Substructure From Data At A Single Wavelength >gi|4929855|pdb|1A7A|B Chain B, Structure Of Human Placental S-Adenosylhomocysteine Hydrolase: Determination Of A 30 Selenium Atom Substructure From Data At A Single Wavelength Length = 432 Score = 273 bits (692), Expect = 1e-72 Identities = 159/400 (39%), Positives = 217/400 (53%), Gaps = 3/400 (0%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G ++ P L + E YS KPL G + +H +TA L TL LGA+V + Sbjct: 18 GRKALDIAENEXPGLXRXRERYSASKPLKGARIAGCLHXTVETAVLIETLVTLGAEVQWS 77 Query: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIYR---ENLMKVLDERPDFIIDDGGDLTV 120 N STQ+ A A+ GI VYA + + Y E + D + I+DDGGDLT Sbjct: 78 SCNIFSTQNHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLNXILDDGGDLTN 137 Query: 121 ISHTEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQ 180 + HT+ ++L ++G+SEETTTGV L G L+VP I VNDS K FDN YG + Sbjct: 138 LIHTKYPQLLPGIRGISEETTTGVHNLYKXXANGILKVPAINVNDSVTKSKFDNLYGCRE 197 Query: 181 STWDAIMRNTNLLVAGKNVVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGF 240 S D I R T++ +AGK VVAGYG VI+TE+DP+ A++A +G+ Sbjct: 198 SLIDGIKRATDVXIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAXEGY 257 Query: 241 TVMPMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVE 300 V EA + + +T +G D++ KD A++ N GHF+VEI V+ L E AVE Sbjct: 258 EVTTXDEACQEGNIFVTTTGCIDIILGRHFEQXKDDAIVCNIGHFDVEIDVKWLNENAVE 317 Query: 301 KFEARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHR 360 K +P V Y L+NG+ + LLAEGRLVNL GHP + SF Q+ A + L + Sbjct: 318 KVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAXGHPSFVXSNSFTNQVXAQIELWTHPD 377 Query: 361 KMSPKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYL 400 K V+ LP ++DE VA L L VK+ +LTEKQ +YL Sbjct: 378 KYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYL 417sp|P27604|SAHH_CAEEL ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE) >gi|156326 (M64306) S-adenosylhomocysteine hydrolase [Caenorhabditis elegans] >gi|298816|bbs|128063 (S57284) S-adenosylhomocysteine hydrolase, AHH [Caenorhabditis elegans, Peptide, 437 aa] [Caenorhabditis elegans] >gi|2804454 (AF043699) C. elegans adenosylhomocysteinase (SW:P27604) [Caenorhabditis elegans] Length = 437 Score = 268 bits (679), Expect = 4e-71 Identities = 156/404 (38%), Positives = 227/404 (55%), Gaps = 7/404 (1%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G +I MP L + +Y +PL G + +H+ +TA L TL+ LGA+V + Sbjct: 19 GRKEIILAENEMPGLMAMRSKYGPSQPLKGARIAGCLHMTIQTAVLIETLTALGAEVQWS 78 Query: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIYR---ENLMKVLDERP-DFIIDDGGDLT 119 N STQD A A+ G+ VYA + + Y E + D +P + I+DDGGDLT Sbjct: 79 SCNIFSTQDHAAAAIAQTGVPVYAWKGETDEEYEWCIEQTIVFKDGQPLNMILDDGGDLT 138 Query: 120 VISHTEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTG 179 + H + + L ++G+SEETTTGV L + G L+VP I VNDS K FDN YG Sbjct: 139 NLVHAKYPQYLAGIRGLSEETTTGVHNLAKMLAKGDLKVPAINVNDSVTKSKFDNLYGIR 198 Query: 180 QSTWDAIMRNTNLLVAGKNVVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDG 239 +S D I R T++++AGK VVAGYG VIVTE+DP+ A++A M+G Sbjct: 199 ESLPDGIKRATDVMLAGKVAVVAGYGDVGKGSAASLKAFGSRVIVTEIDPINALQAAMEG 258 Query: 240 FTVMPMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAV 299 + V ++EA A+ ++T +G D+++ + L + A++ N GHF+ EI V+ L A Sbjct: 259 YEVTTLEEAAPKANIIVTTTGCKDIVTGKHFELLPNDAIVCNVGHFDCEIDVKWLNTNAT 318 Query: 300 EKFEARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYL---L 356 +K +P V YTL+NG+ V LLAEGRLVNL GHP +M SF Q+ A + L Sbjct: 319 KKDTIKPQVDRYTLKNGRHVILLAEGRLVNLGCATGHPSFVMSNSFTNQVLAQVELWTKF 378 Query: 357 ENHRKMSPKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYL 400 ++ +Y+LP +DE VA + L LGVK+ +L+++Q YL Sbjct: 379 GTPQEYKLGLYVLPKTLDEEVAYLHLAQLGVKLTKLSDEQASYL 422ref|NP_010961.1|SAH1| putative S-adenosyl-L-homocysteine hydrolase; Sah1p >gi|730701|sp|P39954|SAHH_YEAST ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE) >gi|1071879|pir||S50546 adenosylhomocysteinase (EC 3.3.1.1) - yeast (Saccharomyces cerevisiae) >gi|603276 (U18796) Sam1p: Adenosylhomocysteinase [Saccharomyces cerevisiae] Length = 449 Score = 264 bits (668), Expect = 8e-70 Identities = 154/416 (37%), Positives = 229/416 (55%), Gaps = 19/416 (4%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G +I MP L I + Y +PL G + +H+ +TA L TL LGA+V + Sbjct: 19 GRKEIELAEHEMPGLMAIRKAYGDVQPLKGARIAGCLHMTIQTAVLIETLVALGAEVTWS 78 Query: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIY----RENLMKVLDERP-DFIIDDGGDL 118 N STQD A A+ + G+ V+A + E Y + L D + + I+DDGGDL Sbjct: 79 SCNIYSTQDHAAAAIAASGVPVFAWKGETEEEYLWCIEQQLFAFKDNKKLNLILDDGGDL 138 Query: 119 TVISHTEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGT 178 T + H + E+LE+ G+SEETTTGV L + + GKL+VP I VNDS K FDN YG Sbjct: 139 TTLVHEKHPEMLEDCFGLSEETTTGVHHLYRMVKEGKLKVPAINVNDSVTKSKFDNLYGC 198 Query: 179 GQSTWDAIMRNTNLLVAGKNVVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMD 238 +S D I R T++++AGK VVAGYG V+VTE+DP+ A++A M+ Sbjct: 199 RESLVDGIKRATDVMLAGKVAVVAGYGDVGKGCAAALRGMGARVLVTEIDPINALQAAME 258 Query: 239 GFTVMPMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIA 298 G+ V+ M++A I +T +G D+++ E +++ + A++ N GHF++EI V L+ A Sbjct: 259 GYQVVTMEDASHIGQVFVTTTGCRDIINGEHFINMPEDAIVCNIGHFDIEIDVAWLKANA 318 Query: 299 VEKFEARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLEN 358 E +P V Y L +G+ V LLA GRLVNL GH +M SF+ Q+ A + L ++ Sbjct: 319 KECINIKPQVDRYLLSSGRHVILLANGRLVNLGCATGHSSFVMSCSFSNQVLAQIALFKS 378 Query: 359 HRK--------------MSPKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYL 400 + K V++LP +DE VA+ L +LGV++ +L++ Q YL Sbjct: 379 NDKSFREKHIEFQKTGPFEVGVHVLPKILDEAVAKFHLGNLGVRLTKLSKVQSEYL 434sp|P36889|SAHH_LEIDO ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE) >gi|159402 (M76556) S-adenosylhomocysteine hydrolase [Leishmania donovani] Length = 437 Score = 261 bits (661), Expect = 6e-69 Identities = 150/408 (36%), Positives = 218/408 (52%), Gaps = 11/408 (2%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G I MP L ++ EY +PL G + +H+ +TA L TL LGA V + Sbjct: 15 GRKAIELAENEMPGLMELRREYGPSQPLKGAKIAGCLHMTVQTAVLIETLKALGADVRWS 74 Query: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIYRENLMKVL-----DERPDFIIDDGGDL 118 N STQD+ A A+ G+ V+A + + Y + + + D P+ I+DDGGDL Sbjct: 75 SCNIFSTQDNAAAAIAKAGVPVFAWKGETDEEYEWCIAQTVKGFSGDGLPNMILDDGGDL 134 Query: 119 TVISHTEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGT 178 T + E++ + G+SEETTTGV+ L G L + I VNDS K FDN YG Sbjct: 135 TNLVIDHHPELVPKIFGISEETTTGVKNLYKRLSKGNLPMCAINVNDSVTKSKFDNLYGC 194 Query: 179 GQSTWDAIMRNTNLLVAGKNVVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMD 238 +S D + R T++++AGK V GYG V+VTEVDP+ A++A M+ Sbjct: 195 RESLVDGMKRATDVMIAGKTCCVCGYGDVGKGCAAALRAFGARVVVTEVDPINALQASME 254 Query: 239 GFTVMPMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIA 298 G+ V +++ + A +T +GN D+++ E ++D A++ N GHF+ EI V LE A Sbjct: 255 GYQVALVEDVMADAHIFVTTTGNDDIITSEHFPHMRDDAIVCNIGHFDTEIQVGWLEANA 314 Query: 299 VEKFEARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLEN 358 E E +P V YT+ENG+ + LLA+GRLVNL GHP +M SF Q+ A + L N Sbjct: 315 KEHVEIKPQVDRYTMENGRHIILLAKGRLVNLGCASGHPSFVMSNSFTNQVLAQIELWSN 374 Query: 359 H------RKMSPKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYL 400 R V+ LP +DE+VA + L +G K+ +LT KQ Y+ Sbjct: 375 RDNGKYPRGDKAGVFFLPKALDEKVAALHLAHVGAKLTKLTPKQAEYI 422pir||A45569 adenosylhomocysteinase (EC 3.3.1.1) - Leishmania donovani Length = 437 Score = 261 bits (660), Expect = 7e-69 Identities = 150/408 (36%), Positives = 218/408 (52%), Gaps = 11/408 (2%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G I MP L ++ EY +PL G + +H+ +TA L TL LGA V + Sbjct: 15 GRKAIELAENEMPGLMELRREYGPSQPLKGAKIAGCLHMTVQTAVLIETLKALGADVRWS 74 Query: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIYRENLMKVL-----DERPDFIIDDGGDL 118 N STQD+ A A+ G+ V+A + + Y + + + D P+ I+DDGGDL Sbjct: 75 SCNIFSTQDNAAAAIAKAGVPVFAWKGETDEEYEWCIAQTVKGFSGDGLPNMILDDGGDL 134 Query: 119 TVISHTEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGT 178 T + E++ + G+SEETTTGV+ L G L + I VNDS K FDN YG Sbjct: 135 TNLVIDHHPELVPKIFGISEETTTGVKNLYKRLSKGNLPMCAINVNDSVTKSKFDNLYGC 194 Query: 179 GQSTWDAIMRNTNLLVAGKNVVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMD 238 +S D + R T++++AGK V GYG V+VTEVDP+ A++A M+ Sbjct: 195 RESLVDGMKRATDVMIAGKTCCVCGYGDVGKGCAAALRAFGARVVVTEVDPINALQASME 254 Query: 239 GFTVMPMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIA 298 G+ V +++ + A +T +GN D+++ E ++D A++ N GHF+ EI V LE A Sbjct: 255 GYQVALVEDVMADAHIFVTTTGNDDIITSEHFPHMRDDAIVCNIGHFDTEIQVGWLEANA 314 Query: 299 VEKFEARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLEN 358 E E +P V YT+ENG+ + LLA+GRLVNL GHP +M SF Q+ A + L N Sbjct: 315 KEHVEIKPQVDFYTMENGRHIILLAKGRLVNLGCASGHPSFVMSNSFTNQVLAQIELWSN 374 Query: 359 H------RKMSPKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYL 400 R V+ LP +DE+VA + L +G K+ +LT KQ Y+ Sbjct: 375 RDNGKYPRGDKAGVFFLPKALDEKVAALHLAHVGAKLTKLTPKQAEYI 422sp|O08364|SAHH_MYCTU ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE) >gi|2072715|emb|CAB08349| (Z95121) sahH [Mycobacterium tuberculosis] Length = 495 Score = 250 bits (633), Expect = 1e-65 Identities = 155/449 (34%), Positives = 234/449 (51%), Gaps = 52/449 (11%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G ++ MP L + EY+ +PL G + S+H+ +TA L TL+ LGA+V Sbjct: 32 GRKELRIAEHEMPGLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWA 91 Query: 64 GSNPLSTQDDVAEAL---------RSKGITVYARRTHDESIYRENLMKVL-----DERPD 109 N STQD A A+ KG+ V+A + Y ++L D+ + Sbjct: 92 SCNIFSTQDHAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPAN 151 Query: 110 FIIDDGGDLTVIS----------------------------------HTEREE---VLEN 132 I+DDGGD T++ T++++ + E+ Sbjct: 152 MILDDGGDATMLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFETDKDKWTKIAES 211 Query: 133 LKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQSTWDAIMRNTNL 192 +KGV+EETTTGV RL G L P I VNDS K FDN+YGT S D I R T+ Sbjct: 212 VKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDA 271 Query: 193 LVAGKNVVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGFTVMPMKEAVKIA 252 L+ GK V++ GYG V VTE+DP+ A++A+M+GF V+ ++EA+ A Sbjct: 272 LIGGKKVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDA 331 Query: 253 DFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVEKFEARPNVTGYT 312 D V+TA+GN D++ E I ++KD A+L N GHF+ EI + LE + +P V +T Sbjct: 332 DIVVTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWT 391 Query: 313 L-ENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHRKMSPKVYMLPD 371 + G+++ +L+EGRL+NL GHP +M SFA Q A + L + + +VY LP Sbjct: 392 FGDTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLPK 451 Query: 372 EIDERVARMKLDSLGVKIDELTEKQRRYL 400 +DE+VAR+ +++LG + +LT++Q YL Sbjct: 452 HLDEKVARIHVEALGGHLTKLTKEQAEYL 480sp|P51540|SAHH_TRIVA ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE) >gi|1118009 (U40872) S-adenosyl-L-homocysteine hydrolase [Trichomonas vaginalis] Length = 486 Score = 247 bits (625), Expect = 9e-65 Identities = 158/448 (35%), Positives = 222/448 (49%), Gaps = 51/448 (11%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G ++ + MP L + E YS KPL G + S+H+ +TA L TL+ LGA V Sbjct: 24 GRKELTLAEKEMPGLMVLRERYSASKPLKGVRISGSLHMTVQTAVLIETLTALGADVRWA 83 Query: 64 GSNPLSTQDDVAEAL---------RSKGITVYARRTHDESIYRENLMKVLD----ERPDF 110 N STQD A A+ + GI V+A + Y EN + L + P Sbjct: 84 SCNIFSTQDTAAAAIVVGPTGTPEKPAGIPVFAWKGETLPEYWENTYRALTWPDGQGPQQ 143 Query: 111 IIDDGGDLTVI-------------------SHTEREEVLENLK----------------- 134 ++DDGGD T++ + E VL LK Sbjct: 144 VVDDGGDATLLISKGFEFETAGAVPEPTEADNLEYRCVLATLKQVFNQDKNHWHTVAAGM 203 Query: 135 -GVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQSTWDAIMRNTNLL 193 GVSEETTTGV RL LE+ GKL P I VND+ K FDN YG S D I R ++++ Sbjct: 204 NGVSEETTTGVHRLYQLEKEGKLLFPAINVNDAVTKSKFDNIYGCRHSLIDGINRASDVM 263 Query: 194 VAGKNVVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGFTVMPMKEAVKIAD 253 + GK +V GYG VI+TEVDP+ A++A+M+G+ V ++E VK D Sbjct: 264 IGGKTALVMGYGDVGKGCAQSLRGQGARVIITEVDPICALQAVMEGYQVRRIEEVVKDVD 323 Query: 254 FVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEI-AVEKFEARPNVTGYT 312 +T +GN D++S + + +KD A++ N GHF+ EI L + ++ +P + Sbjct: 324 IFVTCTGNCDIISVDMMAQMKDKAIVGNIGHFDNEIDTDGLMKYPGIKHIPIKPEYDMWE 383 Query: 313 LENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHRKMSPKVYMLPDE 372 +G + LLAEGRL+NL GHP +M +SF Q A L L E + KVY LP Sbjct: 384 FPDGHAILLLAEGRLLNLGCATGHPSFVMSMSFTNQTLAQLDLYEKRGNLEMKVYTLPKH 443 Query: 373 IDERVARMKLDSLGVKIDELTEKQRRYL 400 +DE V R+ L SL V + +LT+KQ Y+ Sbjct: 444 LDEEVVRLHLGSLDVHLTKLTQKQADYI 471sp|O50562|SAHH_RHOSH ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE) >gi|2661177 (U76671) S-adenosyl L-homocystein hydrolase [Rhodobacter sphaeroides] Length = 463 Score = 247 bits (624), Expect = 1e-64 Identities = 155/436 (35%), Positives = 222/436 (50%), Gaps = 41/436 (9%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G +++ MP L + EE+ KPL G + S+H+ +TA L TL LGA V Sbjct: 15 GRKELDIAETEMPGLMALREEFGASKPLKGARIAGSLHMTVQTAVLIETLVALGADVRWA 74 Query: 64 GSNPLSTQDDVAEALRSKGITVYARR---THDESIYRENLMKVLDERPDFIIDDGGDLTV 120 N STQD A A+ + G+ V+A + D Y + + + D + I+DDGGD T+ Sbjct: 75 SCNIFSTQDHAAAAIAASGVPVFAIKGETLEDYWAYTDKIFQFADGTCNMILDDGGDATL 134 Query: 121 -----------------ISHTEREEVLEN-------------------LKGVSEETTTGV 144 + ++ E L N +KGVSEETTTGV Sbjct: 135 YILLGARVEAGETDLIAVPQSDEEVCLFNQIRKRMAETPGWFTKQRDAIKGVSEETTTGV 194 Query: 145 RRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQSTWDAIMRNTNLLVAGKNVVVAGY 204 RL L + G L P I VNDS K FDN+YG +S D I R T++++AGK VV GY Sbjct: 195 HRLYDLHKKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIRRATDVMMAGKVAVVCGY 254 Query: 205 GWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGFTVMPMKEAVKIADFVITASGNTDV 264 G V VTEVDP+ A++A MDGF V+ +++ V+ AD IT +GN DV Sbjct: 255 GDVGKGSAASLRGAGARVKVTEVDPICALQAAMDGFEVVVLEDVVQDADIFITTTGNRDV 314 Query: 265 LSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVEKFEARPNVTGYTLENGKTVFLLAE 324 + E + +KD A++ N GHF+ EI V L+ + + V + +G + LL+E Sbjct: 315 IRIEHMREMKDMAIVGNIGHFDNEIQVAALKN--HKWTNIKDQVDMIEMPSGSRIILLSE 372 Query: 325 GRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHRKMSPKVYMLPDEIDERVARMKLDS 384 GRL+NL GHP +M SF Q+ A + L P VY+LP +DE+VAR+ L Sbjct: 373 GRLLNLGNATGHPSFVMSASFTNQVLAQIELWTKGADYQPGVYILPKALDEKVARLHLKK 432 Query: 385 LGVKIDELTEKQRRYL 400 +GVK+ ++ +Q Y+ Sbjct: 433 IGVKLTDVRPEQADYI 448sp|P50250|SAHH_PLAF7 ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE) >gi|627050|pir||A54040 adenosylhomocysteinase (EC 3.3.1.1) - Plasmodium falciparum >gi|460639 (U07365) S-adenosylhomocysteine hydrolase [Plasmodium falciparum] Length = 479 Score = 245 bits (618), Expect = 6e-64 Identities = 160/450 (35%), Positives = 228/450 (50%), Gaps = 55/450 (12%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G+M++ MP L +I EEY +++PL + +H+ + A L TL KLGA++ Sbjct: 17 GKMQMEISENEMPGLMRIREEYGKDQPLKNAKITGCLHMTVECALLIETLQKLGAQIRWC 76 Query: 64 GSNPLSTQDDVAEALRS-KGITVYARRTHDESIYRENLMKVL------DERPDFIIDDGG 116 N ST D A A+ + + +TV+A + Y + L D PD I+DDGG Sbjct: 77 SCNIYSTADYAAAAVSTLENVTVFAWKNETLEEYWWCVESALTWGDGDDNGPDMIVDDGG 136 Query: 117 DLTVISH--------------------TEREE-----------VLENLK----------G 135 D T++ H + EE +L+N K G Sbjct: 137 DATLLVHKGVEYEKLYEEKNILPDPEKAKNEEERCFLTLLKNSILKNPKKWTNIAKKIIG 196 Query: 136 VSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQSTWDAIMRNTNLLVA 195 VSEETTTGV RLK +++ +L I VND+ K +DN YG S D +MR T+ L++ Sbjct: 197 VSEETTTGVLRLKKMDKQNELLFTAINVNDAVTKQKYDNVYGCRHSYTDGLMRATDFLIS 256 Query: 196 GKNVVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGFTVMPMKEAVKIADFV 255 GK VV+ GYG V +TE+DP+ A++A+M+GF V+ + E V DF Sbjct: 257 GKIVVICGYGDVGKGCASSMKGLGARVYITEIDPICAIQAVMEGFNVVTLDEIVDKGDFF 316 Query: 256 ITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVL---EEIAVEKFEARPNVTGYT 312 IT +GN DV+ E +L +K+ AV+ N GHF+ EI V L + I +E +P V T Sbjct: 317 ITCTGNVDVIKLEHLLKMKNNAVVGNIGHFDDEIQVNELFNYKGIHIE--NVKPQVDRIT 374 Query: 313 LENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENH--RKMSPKVYMLP 370 L NG + +LA GRL+NL GHP +M SF Q FA L L +N K KVY+LP Sbjct: 375 LPNGNKIIVLARGRLLNLGCATGHPAFVMSFSFCNQTFAQLDLWQNKDTNKYENKVYLLP 434 Query: 371 DEIDERVARMKLDSLGVKIDELTEKQRRYL 400 +DE+VA L L + EL + Q ++L Sbjct: 435 KHLDEKVALYHLKKLNASLTELDDNQCQFL 464dbj|BAA34645| (AB020211) S-adenosyl L-homocystein hydrolase [Roseobacter denitrificans] Length = 462 Score = 244 bits (616), Expect = 1e-63 Identities = 156/434 (35%), Positives = 224/434 (50%), Gaps = 39/434 (8%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G +++ MP L + EY KPL+G + S+H+ +TA L TL LGA V Sbjct: 16 GRKELDIAETEMPGLMALRAEYGDSKPLAGARIVGSLHMTIQTAVLIETLVALGADVRWA 75 Query: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIYRENLMK--VLDERPDFIIDDGGDLTV- 120 N STQD A A+ + G V+A + + + L + + ++ P+ I+DDGGD T+ Sbjct: 76 SCNIFSTQDHAAAAIAAGGTPVFAIKGQSLEEHWDYLDRSFMFEDGPNLILDDGGDATLY 135 Query: 121 ---------------ISHTEREEVL-------------------ENLKGVSEETTTGVRR 146 + +E EE + + +KGVSEETTTGV R Sbjct: 136 VLLGARAEAGEEIIPVPTSEEEEAIKAQIKKRMAASPGWFTKVRDQIKGVSEETTTGVHR 195 Query: 147 LKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQSTWDAIMRNTNLLVAGKNVVVAGYGW 206 L L + G+L P I VNDS K FDN+YG +S D I R T+ ++AGK VV GYG Sbjct: 196 LYDLVKQGQLPFPAINVNDSVTKSKFDNKYGCKESLVDGIRRATDTMMAGKVAVVMGYGD 255 Query: 207 CXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGFTVMPMKEAVKIADFVITASGNTDVLS 266 V VTEVDP+ A++A MDGF V+ +++ V AD IT +GN DV+ Sbjct: 256 VGKGSAASLRGAGARVKVTEVDPICALQAAMDGFEVVLLEDVVGSADIFITTTGNKDVIR 315 Query: 267 KEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVEKFEARPNVTGYTLENGKTVFLLAEGR 326 E + ++KD A++ N GHF+ EI V L+ + + V + NG + LL+EGR Sbjct: 316 IEHMRAMKDMAIVGNIGHFDNEIQVAALKN--HKWTNIKEQVDMIEMPNGNRLILLSEGR 373 Query: 327 LVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHRKMSPKVYMLPDEIDERVARMKLDSLG 386 L+NL GHP +M SF Q+ A + L +VY+LP +DE+VAR+ LD +G Sbjct: 374 LLNLGNATGHPSFVMSASFTNQVLAQIELWTRADAYDNEVYILPKHLDEKVARLHLDRIG 433 Query: 387 VKIDELTEKQRRYL 400 VK+ L +Q Y+ Sbjct: 434 VKLTPLDPEQAAYI 447sp|Q12663|SAHH_PNECA ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE) >gi|1401142 (U57795) S-adenosylhomocysteine hydrolase [Pneumocystis carinii f. sp. ratti] Length = 440 Score = 240 bits (607), Expect = 1e-62 Identities = 149/396 (37%), Positives = 212/396 (52%), Gaps = 24/396 (6%) Query: 27 REKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVITGSNPLSTQDDVAEALRSKGITVY 86 R KPL G +H+ +TA L TL +LGA+V + N STQD A A+ + GI+V+ Sbjct: 32 RFKPLRVQIAGC-LHMTIQTAVLIETLVELGAEVTWSSCNIFSTQDHAAAAIAASGISVF 90 Query: 87 ARRTHDESIYRENLMKVLDERPD-----FIIDDGGDLTVISHTEREEVLENLKGVSEETT 141 A + E Y + L D I+DDGGD+T + H + + L+N KG+SEETT Sbjct: 91 AWKGETEEEYLWCIETQLTSFKDGKHLNMILDDGGDVTSLVHNKYPDYLKNCKGISEETT 150 Query: 142 TGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTG----------------QSTWDA 185 TGV + + + GKL+VP I VNDS K FDN YG +S D Sbjct: 151 TGVHQFYKMLKEGKLKVPAINVNDSVTKSKFDNLYGVSLVLIYKIISNIKLRCRESLIDG 210 Query: 186 IMRNTNLLVAGKNVVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGFTVMPM 245 I R T++++A K +VAG+G VI+TE+DP+ A++A M+G+ V M Sbjct: 211 IKRATDIMIAAKVAIVAGFGDVGKGCAKALRGMGARVIITEIDPIVALQASMEGYQVAVM 270 Query: 246 KEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVEKFEAR 305 +E AD +TA+G D++ + ++K+ A++ N GHF+VEI V L + + Sbjct: 271 EEVADQADIFVTATGCKDIICERHFEAMKNDAIICNIGHFDVEIDVAWLIKKCSSISNIK 330 Query: 306 PNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHRKMSP- 364 P V Y L NG+ + LLAEGRLVNL GH +M +SF Q+ A + L P Sbjct: 331 PQVDRYLLGNGRNIILLAEGRLVNLGCATGHSSMVMSMSFTNQVLAQIALWTAQEGQYPL 390 Query: 365 KVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYL 400 V+ LP ++DE VAR+ L LG K+ LT +Q YL Sbjct: 391 GVHFLPKKLDEEVARLHLSKLG-KLTSLTPEQSAYL 425sp|P28183|SAHH_RHOCA ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE) >gi|151884 (M80630) adenosylhomocysteine hydrolase [Rhodobacter capsulatus] Length = 463 Score = 237 bits (599), Expect = 1e-61 Identities = 153/436 (35%), Positives = 217/436 (49%), Gaps = 41/436 (9%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G +++ MP L EE+ +PL G + S+H+ +TA L TL LGA V Sbjct: 15 GRKELDIAETEMPGLMACREEFGPSQPLKGARIAGSLHMTIQTAVLIETLKALGADVRWA 74 Query: 64 GSNPLSTQDDVAEALRSKGITVYARR---THDESIYRENLMKVLDERPDFIIDDGGDLT- 119 N STQD A A+ + G V+A + + Y + + + + + I+DDGGD T Sbjct: 75 SCNIFSTQDHAAAAIAAGGTPVFAVKGETLEEYWAYTDKIFQFPEGTCNMILDDGGDATL 134 Query: 120 ---------------VISHTEREEVL--------------------ENLKGVSEETTTGV 144 + + T +EV +KGVSEETTTGV Sbjct: 135 YILLGARVEAGETDLIATPTSEDEVCLFNQIKKRMVESPGWFTQQRAAIKGVSEETTTGV 194 Query: 145 RRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQSTWDAIMRNTNLLVAGKNVVVAGY 204 RL L + G L P I VNDS K FDN+YG +S D I R T++++AGK VV GY Sbjct: 195 HRLYDLHKKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIRRATDVMMAGKVAVVCGY 254 Query: 205 GWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGFTVMPMKEAVKIADFVITASGNTDV 264 G V VTEVDP+ A++A MDGF V+ +++ V AD IT +GN DV Sbjct: 255 GDVGKGSAASLRGAGARVKVTEVDPICALQAAMDGFEVVVLEDVVADADIFITTTGNKDV 314 Query: 265 LSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVEKFEARPNVTGYTLENGKTVFLLAE 324 + E + +KD A++ N GHF+ EI V L+ + + V + +G + LL+E Sbjct: 315 IRIEHMREMKDMAIVGNIGHFDNEIQVAALKN--HKWTNIKDQVDMIEMPSGARIILLSE 372 Query: 325 GRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHRKMSPKVYMLPDEIDERVARMKLDS 384 GRL+NL GHP +M SF Q+ A + L + P VY+LP +DE+VAR+ L Sbjct: 373 GRLLNLGNATGHPSFVMSASFTNQVLAQIELWTKGAEYQPGVYILPKSLDEKVARLHLKK 432 Query: 385 LGVKIDELTEKQRRYL 400 +GVK+ L Q Y+ Sbjct: 433 IGVKLTTLRPDQAEYI 448sp|P32112|SAHH_WHEAT ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE) >gi|170773 (L11872) S-adenosyl-L-homocysteine hydrolase [Triticum aestivum] Length = 485 Score = 236 bits (596), Expect = 2e-61 Identities = 148/446 (33%), Positives = 221/446 (49%), Gaps = 49/446 (10%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G +++ MP L E+ +P G + S+H+ +TA L TL+ LGA+V Sbjct: 25 GRLELELAEVEMPGLMACRTEFGPSQPFKGARISGSLHMTIQTAVLIETLTALGAEVRWC 84 Query: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIYRENLMKVLD----ERPDFIIDDGGDLT 119 N S+QD A A+ V+A + Y + LD PD I+DDGGD T Sbjct: 85 SCNIFSSQDHAAAAIARDSAAVFAWKGETLEEYWWCTERCLDWGVGGGPDLIVDDGGDAT 144 Query: 120 VISH-----------------------------------------TEREEVLENLKGVSE 138 ++ H ++ ++ E L GVSE Sbjct: 145 LLIHEGVKAEEEFEKSGKVPDPESTDNPEFKIVLTIIRDGLKTDASKYRKMKERLVGVSE 204 Query: 139 ETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQSTWDAIMRNTNLLVAGKN 198 ETTTGV+RL ++E+G L P I VNDS K FDN YG S D +MR T++++AGK Sbjct: 205 ETTTGVKRLYQMQESGTLLFPAINVNDSVTKSKFDNLYGCRHSLPDGLMRATDVMIAGKV 264 Query: 199 VVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGFTVMPMKEAVKIADFVITA 258 VV GYG VIVTE+DP+ A++A+M+G ++ +++ V AD +T Sbjct: 265 AVVCGYGDVGKGCAAALKQAGARVIVTEIDPICALQALMEGIQILTLEDVVSEADIFVTT 324 Query: 259 SGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEI-AVEKFEARPNVTGYTLENGK 317 +GN D++ + + +K+ A++ N GHF+ EI + LE V++ +P + K Sbjct: 325 TGNKDIIMVDHMRKMKNNAIVCNIGHFDNEIDMNGLETYPGVKRITIKPQTDRWVFPETK 384 Query: 318 T-VFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHR--KMSPKVYMLPDEID 374 T + +LAEGRL+NL GHP +M SF Q+ A L L K KVY+LP +D Sbjct: 385 TGIIVLAEGRLMNLGCATGHPSFVMSCSFTNQVIAQLELWNEKASGKYEKKVYVLPKHLD 444 Query: 375 ERVARMKLDSLGVKIDELTEKQRRYL 400 E+VA + L LG ++ +LT+ Q Y+ Sbjct: 445 EKVAALHLGKLGARLTKLTKSQSDYI 470sp|P50246|SAHH_MEDSA ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE) >gi|535584 (L36119) adenosylhomocysteinase [Medicago sativa] Length = 485 Score = 236 bits (595), Expect = 3e-61 Identities = 150/446 (33%), Positives = 222/446 (49%), Gaps = 49/446 (10%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G ++I MP L E+ +P G + S+H+ +TA L TL+ LGA+V Sbjct: 25 GRLEIELAEVEMPGLMSCRTEFGPSQPFKGARITGSLHMTIQTAVLIETLTALGAEVRWC 84 Query: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIYRENLMKVLD----ERPDFIIDDGGDLT 119 N STQD A A+ V+A + Y + LD PD I+DDGGD+T Sbjct: 85 SCNIFSTQDHAAAAIARDSAAVFAWKGETLQEYWWCSERALDWGPGGGPDLIVDDGGDVT 144 Query: 120 VISH--TEREEVLEN---------------------------------------LKGVSE 138 ++ H + EEV E + GVSE Sbjct: 145 LLIHEGVKAEEVFEKTGQLPDPSSTDNAEMQIVLTIIRDGLKTDPKRYQKMKTRIVGVSE 204 Query: 139 ETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQSTWDAIMRNTNLLVAGKN 198 ETTTGV+RL ++ +G L P I VNDS K FDN YG S D +MR T++++AGK Sbjct: 205 ETTTGVKRLYQMQASGTLLFPAINVNDSVTKSKFDNLYGCRHSLPDGLMRATDVMIAGKV 264 Query: 199 VVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGFTVMPMKEAVKIADFVITA 258 VV GYG VIVTE+DP+ A++A+M+G V+ +++ + AD +T Sbjct: 265 AVVCGYGDVGKGCAAALKQGGARVIVTEIDPICALQALMEGLQVLTLEDVISEADIFVTT 324 Query: 259 SGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEI-AVEKFEARPNVTGYTLENGK 317 +GN D++ D+ +K+ A++ N GHF+ EI + LE V++ +P + K Sbjct: 325 TGNKDIIMVSDMKKMKNNAIVCNIGHFDNEIDMHGLETYPGVKRITIKPQTDRWVFPETK 384 Query: 318 T-VFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHR--KMSPKVYMLPDEID 374 + + +LAEGRL+NL GHP +M SF Q+ A + L + K KVY+LP +D Sbjct: 385 SGIIVLAEGRLMNLGCATGHPSFVMSCSFTNQVIAQIELWKEKTSGKYEKKVYVLPKHLD 444 Query: 375 ERVARMKLDSLGVKIDELTEKQRRYL 400 E+VA + L LG K+ +L++ Q Y+ Sbjct: 445 EKVAALHLGQLGAKLTKLSKDQADYI 470sp|Q01781|SAHH_PETCR ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE) >gi|169663 (M81885) S-adenosylhomocysteine hydrolase [Petroselinum crispum] Length = 485 Score = 235 bits (594), Expect = 4e-61 Identities = 148/446 (33%), Positives = 222/446 (49%), Gaps = 49/446 (10%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G +++ MP L E+ +P G + S+H+ +T L TL+ LGA+V Sbjct: 25 GRLELELAEVEMPGLMSCRTEFGPSQPFKGARITGSLHMTIQTGVLIETLTALGAEVRWC 84 Query: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIYRENLMKVLD----ERPDFIIDDGGDLT 119 N STQD A A+ V+A + Y + LD PD I+DDGGD T Sbjct: 85 SCNIFSTQDHAAAAIARDSCAVFAWKGETLQEYWWCTERALDWGPDGGPDLIVDDGGDAT 144 Query: 120 VISH--------------------TEREE---------------------VLENLKGVSE 138 ++ H T+ E + + L GVSE Sbjct: 145 LLIHEGVKAEEEYKKSGAIPDPASTDNAEFQIVLSIIRDGLKSDPMKYHKMKDRLVGVSE 204 Query: 139 ETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQSTWDAIMRNTNLLVAGKN 198 ETTTGV+RL +++ G L P I VNDS K FDN YG S D +MR T++++AGK Sbjct: 205 ETTTGVKRLYQMQQNGTLLFPAINVNDSVTKSKFDNLYGCRHSLPDGLMRATDVMIAGKV 264 Query: 199 VVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGFTVMPMKEAVKIADFVITA 258 ++AGYG VIVTE+DP+ A++A M+G V+P+++ V D +T Sbjct: 265 ALIAGYGDVGKGCAAAMKQAGARVIVTEIDPICALQATMEGLQVLPLEDVVSEVDIFVTT 324 Query: 259 SGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEI-AVEKFEARPNVTGYTL-ENG 316 +GN D++ D+ +K+ A++ N GHF+ EI + LE V++ +P + + G Sbjct: 325 TGNKDIIMVSDMRKMKNNAIVCNIGHFDNEIDMLGLETYPGVKRITIKPQTDRWVFPDTG 384 Query: 317 KTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLL--ENHRKMSPKVYMLPDEID 374 + + +LAEGRL+NL GHP +M SF Q+ A L L ++ K KVY+LP +D Sbjct: 385 RGIIILAEGRLMNLGCATGHPSFVMSCSFTNQVIAQLELWNEKSSGKYEKKVYVLPKHLD 444 Query: 375 ERVARMKLDSLGVKIDELTEKQRRYL 400 E+VA + L LG K+ +L++ Q Y+ Sbjct: 445 EKVAALHLGKLGAKLTKLSKDQADYI 470sp|P35007|SAHH_CATRO ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE) >gi|481237|pir||S38379 adenosylhomocysteinase (EC 3.3.1.1) - Madagascar periwinkle >gi|407412|emb|CAA81527| (Z26881) S-adenosyl-L-homocysteine hydrolase [Catharanthus roseus] Length = 485 Score = 235 bits (592), Expect = 7e-61 Identities = 150/446 (33%), Positives = 218/446 (48%), Gaps = 49/446 (10%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G ++I MP L E+ +P G + S+H+ +TA L TL+ LGA+V Sbjct: 25 GRLEIELAEVEMPGLMSCRAEFGPSQPFKGAKITGSLHMTIQTAVLIETLTALGAEVRWC 84 Query: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIYRENLMKVLD----ERPDFIIDDGGDLT 119 N STQ+ A A+ V+A + Y + LD PD I+DDGGD T Sbjct: 85 SCNIFSTQEHAAAAIARDSAAVFAWKGETLQEYWWCTERALDWGPDGGPDLIVDDGGDAT 144 Query: 120 VISH-----------------------------------------TEREEVLENLKGVSE 138 ++ H T+ + E L GVSE Sbjct: 145 LLIHEGVKAEEEYKKNGALPDPSSTDNAEFQIVLTIIRDGLKSDPTKYTRMKERLVGVSE 204 Query: 139 ETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQSTWDAIMRNTNLLVAGKN 198 ETTTGV+RL ++ G L P I VNDS K FDN YG S D +MR T++++AGK Sbjct: 205 ETTTGVKRLYQMQANGTLLFPAINVNDSVTKSKFDNLYGCRHSLPDGLMRATDVMIAGKV 264 Query: 199 VVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGFTVMPMKEAVKIADFVITA 258 VVAGYG VIVTE+DP+ A++A M+G V+ +++ V AD +T Sbjct: 265 AVVAGYGDVGKGCAAALKQAGARVIVTEIDPICALQATMEGLQVLTLEDVVSEADIFVTT 324 Query: 259 SGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEI-AVEKFEARPNVTGYTL-ENG 316 +GN D++ + + +K+ A++ N GHF+ EI + LE V++ +P + + Sbjct: 325 TGNKDIIMVDHMRKMKNNAIVCNIGHFDNEIDMLGLETYPGVKRITIKPQTDRWVFPDTN 384 Query: 317 KTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHR--KMSPKVYMLPDEID 374 + +LAEGRL+NL GHP +M SF Q+ A L L + K KVY+LP +D Sbjct: 385 SGIIVLAEGRLMNLGCATGHPSFVMSCSFTNQVIAQLELWNERKTGKYEKKVYVLPKHLD 444 Query: 375 ERVARMKLDSLGVKIDELTEKQRRYL 400 E+VA + L LG K+ +LT+ Q Y+ Sbjct: 445 EKVAALHLGKLGAKLTKLTKDQADYI 470gb|AAD56048.1|AF185635_1 (AF185635) S-adenosyl-L-homocysteinase [Lupinus luteus] Length = 485 Score = 233 bits (589), Expect = 2e-60 Identities = 151/446 (33%), Positives = 221/446 (48%), Gaps = 49/446 (10%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G ++I MP L E+ +P G + S+H+ +TA L TL+ LGA+V Sbjct: 25 GRLEIELAEVEMPGLMASRSEFGPSQPFKGAKITGSLHMTIQTAVLIETLTALGAEVRWC 84 Query: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIYRENLMKVLD----ERPDFIIDDGGDLT 119 N STQD A A+ V+A + Y + LD PD I+DDGGD T Sbjct: 85 SCNIFSTQDHAAAAIARDSAAVFAWKGETLQEYWWCTERALDWGPGGGPDLIVDDGGDTT 144 Query: 120 VISH--TEREEVLEN---------------------------------------LKGVSE 138 ++ H + EE+ E + GVSE Sbjct: 145 LLIHEGVKAEEIYEKSGQFPDPDSTDNAEFKIVLSIIKEGLKTDPKRYHKMKDRVVGVSE 204 Query: 139 ETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQSTWDAIMRNTNLLVAGKN 198 ETTTGV+RL ++ G L P I VNDS K FDN YG S D +MR T++++AGK Sbjct: 205 ETTTGVKRLYQMQANGTLLFPAINVNDSVTKSKFDNLYGCRHSLPDGLMRATDVMIAGKV 264 Query: 199 VVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGFTVMPMKEAVKIADFVITA 258 VVAGYG VIVTE+DP+ A++A M+G V+ +++ V AD +T Sbjct: 265 AVVAGYGDVGKGCAAALKQAGARVIVTEIDPICALQATMEGLQVLTLEDVVSEADIFVTT 324 Query: 259 SGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLE-EIAVEKFEARPNVTGYTL-ENG 316 +GN D++ + + +K+ A++ N GHF+ EI + LE V++ +P + E Sbjct: 325 TGNKDIIMLDHMKKMKNNAIVCNIGHFDNEIDMLGLETHPGVKRITIKPQTDRWVFPETN 384 Query: 317 KTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLL--ENHRKMSPKVYMLPDEID 374 + +LAEGRL+NL GHP +M SF Q+ A L L ++ K KVY+LP +D Sbjct: 385 TGIIILAEGRLMNLGCATGHPSFVMSCSFTNQVIAQLELWNEKSSGKYEKKVYVLPKHLD 444 Query: 375 ERVARMKLDSLGVKIDELTEKQRRYL 400 E+VA + L+ LG K+ +L++ Q Y+ Sbjct: 445 EKVAALHLEKLGAKLTKLSKDQADYI 470sp|P93253|SAHH_MESCR ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE) >gi|1724102 (U79766) S-adenosyl-L-homocystein hydrolase; SAH [Mesembryanthemum crystallinum] Length = 485 Score = 232 bits (586), Expect = 3e-60 Identities = 151/446 (33%), Positives = 218/446 (48%), Gaps = 49/446 (10%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G ++I MP L E+ +P G + S+H+ +TA L TL+ LGA+V Sbjct: 25 GRLEIELAEVEMPGLMACRTEFGPSQPFKGAKITGSLHMTIQTAVLIETLTALGAEVRWC 84 Query: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIYRENLMKVLD----ERPDFIIDDGGDLT 119 N STQD A A+ V+A + Y + LD PD I+DDGGD T Sbjct: 85 SCNIFSTQDHAAAAIARDSAAVFAWKGETLQEYWWCTERALDWGAGGGPDLIVDDGGDAT 144 Query: 120 VISH--TEREEVLEN---------------------------------------LKGVSE 138 ++ H + EE E L GVSE Sbjct: 145 LLIHEGVKAEEEYEKNGTIPDPTSTDNPEFQLVLGLIRDSLKVDPKRYHKMKTRLVGVSE 204 Query: 139 ETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQSTWDAIMRNTNLLVAGKN 198 ETTTGV+RL ++ TG L P I VNDS K FDN YG S D +MR T++++AGK Sbjct: 205 ETTTGVKRLYQMQATGTLLFPAINVNDSVTKSKFDNLYGCRHSLPDGLMRATDVMIAGKV 264 Query: 199 VVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGFTVMPMKEAVKIADFVITA 258 VV GYG VIVTE+DP+ A++A+M+GF ++ +++ V AD +T Sbjct: 265 GVVCGYGDVGKGCALALKAAGARVIVTEIDPICALQALMEGFQILTLEDVVSEADIFVTT 324 Query: 259 SGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEI-AVEKFEARPNVTGYTL-ENG 316 +GN D++ + + +K+ A++ N GHF+ EI + LE V++ +P + E Sbjct: 325 TGNKDIIMVDHMRKMKNNAIVCNIGHFDNEIDMLGLENYPGVKRITIKPQTDRFVFPETN 384 Query: 317 KTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHR--KMSPKVYMLPDEID 374 + +LAEGRL+ L GHP +M SF Q+ A L L K KVY+LP +D Sbjct: 385 TGIIVLAEGRLMKLGCATGHPSFVMSCSFTNQVIAQLELWNERASGKYEKKVYVLPKHLD 444 Query: 375 ERVARMKLDSLGVKIDELTEKQRRYL 400 E+VA + L LG K+ +L++ Q Y+ Sbjct: 445 EKVAALHLGKLGAKLTKLSKDQADYI 470pir||A46035 adenosylhomocysteinase (EC 3.3.1.1) - Rhodobacter capsulatus Length = 462 Score = 232 bits (585), Expect = 5e-60 Identities = 153/436 (35%), Positives = 217/436 (49%), Gaps = 42/436 (9%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G +++ MP L EE+ +PL G + S+H+ +TA L TL LGA V Sbjct: 15 GRKELDIAETEMPGLMACREEFGPSQPLKGARIAGSLHMTIQTAVLIETLKALGADVRWA 74 Query: 64 GSNPLSTQDDVAEALRSKGITVYARR---THDESIYRENLMKVLDERPDFIIDDGGDLT- 119 N STQD A A+ + G V+A + + Y + + + + + I+DDGGD T Sbjct: 75 SCNIFSTQDHAAAAIAAGGTPVFAVKGETLEEYWAYTDKIFQFPEGTCNMILDDGGDATL 134 Query: 120 ---------------VISHTEREEVL--------------------ENLKGVSEETTTGV 144 + + T +EV +KGVSEETTTGV Sbjct: 135 YILLGARVEAGETDLIATPTSEDEVCLFNQIKKRMVESPGWFTQQRAAIKGVSEETTTGV 194 Query: 145 RRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQSTWDAIMRNTNLLVAGKNVVVAGY 204 RL L + G L P I VNDS K FDN+YG +S D I R T++++AGK VV GY Sbjct: 195 HRLYDLHKKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIRRATDVMMAGKVAVVCGY 254 Query: 205 GWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGFTVMPMKEAVKIADFVITASGNTDV 264 G V VTEVDP+ A++A MDGF V+ +++ V A F IT +GN DV Sbjct: 255 GDVGKGSAASLRGAGARVKVTEVDPICALQAAMDGFEVVVLEDVVADAIF-ITTTGNKDV 313 Query: 265 LSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVEKFEARPNVTGYTLENGKTVFLLAE 324 + E + +KD A++ N GHF+ EI V L+ + + V + +G + LL+E Sbjct: 314 IRIEHMREMKDMAIVGNIGHFDNEIQVAALKN--HKWTNIKDQVDMIEMPSGARIILLSE 371 Query: 325 GRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHRKMSPKVYMLPDEIDERVARMKLDS 384 GRL+NL GHP +M SF Q+ A + L + P VY+LP +DE+VAR+ L Sbjct: 372 GRLLNLGNATGHPSFVMSASFTNQVLAQIELWTKGAEYQPGVYILPKSLDEKVARLHLKK 431 Query: 385 LGVKIDELTEKQRRYL 400 +GVK+ L Q Y+ Sbjct: 432 IGVKLTTLRPDQAEYI 447sp|O23255|SAHH_ARATH ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE) >gi|2244750|emb|CAB10173.1| (Z97335) adenosylhomocysteinase [Arabidopsis thaliana] >gi|3088579|gb|AAC14714.1| (AF059581) S-adenosyl-L-homocysteine hydrolase [Arabidopsis thaliana] Length = 485 Score = 231 bits (584), Expect = 6e-60 Identities = 148/446 (33%), Positives = 219/446 (48%), Gaps = 49/446 (10%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G +++ MP L E+ +P G + S+H+ +TA L TL+ LGA+V Sbjct: 25 GRLELELAEVEMPGLMACRTEFGPSQPFKGARITGSLHMTIQTAVLIETLTALGAEVRWC 84 Query: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIYRENLMKVLD----ERPDFIIDDGGDLT 119 N STQD A A+ V+A + Y + LD PD I+DDGGD T Sbjct: 85 SCNIFSTQDHAAAAIARDSAAVFAWKGETLQEYWWCTERALDWGPGGGPDLIVDDGGDAT 144 Query: 120 VISH--TEREEVLEN---------------------------------------LKGVSE 138 ++ H + EE+ E L GVSE Sbjct: 145 LLIHEGVKAEEIFEKTGQVPDPTSTDNPEFQIVLSIIKEGLQVDPKKYHKMKERLVGVSE 204 Query: 139 ETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQSTWDAIMRNTNLLVAGKN 198 ETTTGV+RL +++ G L P I VNDS K FDN YG S D +MR T++++AGK Sbjct: 205 ETTTGVKRLYQMQQNGTLLFPAINVNDSVTKSKFDNLYGCRHSLPDGLMRATDVMIAGKV 264 Query: 199 VVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGFTVMPMKEAVKIADFVITA 258 V+ GYG VIVTE+DP+ A++A+M+G V+ +++ V AD +T Sbjct: 265 AVICGYGDVGKGCAAAMKTAGARVIVTEIDPICALQALMEGLQVLTLEDVVSEADIFVTT 324 Query: 259 SGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEI-AVEKFEARPNVTGYTLENGK 317 +GN D++ + + +K+ A++ N GHF+ EI + LE V++ +P + K Sbjct: 325 TGNKDIIMVDHMRKMKNNAIVCNIGHFDNEIDMLGLETYPGVKRITIKPQTDRWVFPETK 384 Query: 318 T-VFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHR--KMSPKVYMLPDEID 374 + +LAEGRL+NL GHP +M SF Q+ A L L K KVY+LP +D Sbjct: 385 AGIIVLAEGRLMNLGCATGHPSFVMSCSFTNQVIAQLELWNEKASGKYEKKVYVLPKHLD 444 Query: 375 ERVARMKLDSLGVKIDELTEKQRRYL 400 E+VA + L LG ++ +L++ Q Y+ Sbjct: 445 EKVALLHLGKLGARLTKLSKDQSDYV 470dbj|BAA74851.1| (AB020635) KIAA0828 protein [Homo sapiens] Length = 619 Score = 231 bits (582), Expect = 1e-59 Identities = 139/401 (34%), Positives = 212/401 (52%), Gaps = 5/401 (1%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G +I + MP L + + EKPL+G + H+ A+TA L TL LGA+ Sbjct: 205 GRREIEIAEQEMPALMALRKRAQGEKPLAGAKIVGCTHITAQTAVLMETLGALGAQCRWA 264 Query: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIYR---ENLMKVLDERPDFIIDDGGDLTV 120 N ST ++VA AL G V+A + E + + + V +P+ I+DDGGDLT Sbjct: 265 ACNIYSTLNEVAAALAESGFPVFAWKGESEDDFWWCIDRCVNVEGWQPNMILDDGGDLTH 324 Query: 121 ISHTEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQ 180 + + + + +KG+ EE+ TGV RL L + GKL VP + VNDS K FDN Y + Sbjct: 325 WIYKKYPNMFKKIKGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRE 384 Query: 181 STWDAIMRNTNLLVAGKNVVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGF 240 S D + R T+++ GK VVV GYG V VTE+DP+ A++A MDGF Sbjct: 385 SILDGLKRTTDMMFGGKQVVVCGYGEVGKGCCAALKAMGSIVYVTEIDPICALQACMDGF 444 Query: 241 TVMPMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVE 300 ++ + E ++ D VIT +GN +V+++E + +K+ ++ N GH N EI V L + Sbjct: 445 RLVKLNEVIRQVDIVITCTGNKNVVTREHLDRMKNSCIVCNMGHSNTEIDVASLRTPELT 504 Query: 301 KFEARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLE-NH 359 R V +GK + LLAEGRL+NL+ P ++ ++ Q A++ L Sbjct: 505 WERVRSQVDHVIWPDGKRIVLLAEGRLLNLSCST-VPTFVLSITATTQALALIELYNAPE 563 Query: 360 RKMSPKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYL 400 + VY+LP ++DE VA + L + + ELT++Q +YL Sbjct: 564 GRYKQDVYLLPKKMDEYVASLHLPTFDAHLTELTDEQAKYL 604sp|P50249|SAHH_PHASS ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE) >gi|758247|emb|CAA56278| (X79905) S-adenosylhomocysteine hydrolase [Phalaenopsis sp.] Length = 485 Score = 231 bits (582), Expect = 1e-59 Identities = 150/446 (33%), Positives = 218/446 (48%), Gaps = 49/446 (10%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G ++I MP L E+ +P G + S+H+ +TA L TL+ LGA+V Sbjct: 25 GRLEIELAEVEMPGLMACRAEFGPSQPFKGARISGSLHMTIQTAVLIETLTALGAEVRWC 84 Query: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIYRENLMKVLD----ERPDFIIDDGGDLT 119 N STQD A A+ V+A + Y + L+ PD I+DDGGD T Sbjct: 85 SCNIFSTQDHAAAAIARDSAAVFAWKGETLQEYWWCTERCLEWGAGGGPDLIVDDGGDAT 144 Query: 120 VISH--------------------TEREE---------------------VLENLKGVSE 138 ++ H T+ E + E L GVSE Sbjct: 145 LLIHEGVKAEEEYEKNGKIPDPASTDNAEFQIVLGLIRDSLSVDPKKYRRMKERLVGVSE 204 Query: 139 ETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQSTWDAIMRNTNLLVAGKN 198 ETTTGV+RL ++ +G L P I VNDS K FDN YG S D +MR T++++AGK Sbjct: 205 ETTTGVKRLYQMQYSGTLLFPAINVNDSVTKSKFDNLYGCRHSLPDGLMRATDVMIAGKV 264 Query: 199 VVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGFTVMPMKEAVKIADFVITA 258 VV GYG VIVTE+DP+ A++A+M+G V+ +++ V AD +T Sbjct: 265 AVVCGYGDVGLGCAAALKTAGARVIVTEIDPICALQALMEGLPVLRLEDVVSEADIFVTT 324 Query: 259 SGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEI-AVEKFEARPNVTGYTL-ENG 316 +GN D++ + + +K+ A++ N GHF+ EI + LE V++ +P + Sbjct: 325 TGNKDIIMVDHMRKMKNNAIVCNIGHFDNEIDMLGLESFPGVKRITIKPQTDRRVFPDTN 384 Query: 317 KTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHR--KMSPKVYMLPDEID 374 + +LAEGRL+NL GHP +M SF Q+ A L L + K KVY+LP +D Sbjct: 385 SGILVLAEGRLMNLGCATGHPSFVMSSSFTNQVIAQLELWKERASGKYEKKVYVLPKHLD 444 Query: 375 ERVARMKLDSLGVKIDELTEKQRRYL 400 E+VA + L LG K+ +LT Q Y+ Sbjct: 445 EKVAALHLGKLGAKLTKLTPSQADYI 470sp|P50248|SAHH_TOBAC ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE) (CYTOKININ BINDING PROTEIN CBP57) >gi|441217|dbj|BAA03709| (D16138) S-adenosyl-L-homocystein hydrolase [Nicotiana sylvestris] >gi|1857024|dbj|BAA08142| (D45204) S-adenosyl-L-homocysteine hydrolase [Nicotiana tabacum] >gi|2588781|dbj|BAA23164| (D49804) S-adenosyl-L-homocysteine hydrolase [Nicotiana tabacum] Length = 485 Score = 229 bits (578), Expect = 3e-59 Identities = 149/446 (33%), Positives = 219/446 (48%), Gaps = 49/446 (10%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G ++I MP L E+ +P G + S+H+ +TA L TL+ LGA+V Sbjct: 25 GRLEIELAEVEMPGLMACRTEFGPSQPFKGAKITGSLHMTIQTAVLIETLTALGAEVRWC 84 Query: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIYRENLMKVLD----ERPDFIIDDGGDLT 119 N STQD A A+ V+A + Y + LD PD I+DDGGD T Sbjct: 85 SCNIFSTQDHAAAAIARDSAAVFAWKGETLQEYWWCTERALDWGPGGGPDLIVDDGGDAT 144 Query: 120 VISH--------------------TEREE---------------------VLENLKGVSE 138 ++ H T+ E + E L GVSE Sbjct: 145 LLIHEGVKAEEEFAKNGTIPDPNSTDNAEFQLVLTIIKESLKTDPLKYTKMKERLVGVSE 204 Query: 139 ETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQSTWDAIMRNTNLLVAGKN 198 ETTTGV+RL ++ G L P I VNDS K FDN YG S D +MR T++++AGK Sbjct: 205 ETTTGVKRLYQMQANGTLLFPAINVNDSVTKSKFDNLYGCRHSLPDGLMRATDVMIAGKV 264 Query: 199 VVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGFTVMPMKEAVKIADFVITA 258 +VAGYG VIVTE+DP+ A++A M+G V+ +++ V D +T Sbjct: 265 ALVAGYGDVGKGCAAALKQAGARVIVTEIDPICALQATMEGLQVLTLEDVVSDVDIFVTT 324 Query: 259 SGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEI-AVEKFEARPNVTGYTL-ENG 316 +GN D++ + + +K+ A++ N GHF+ EI + LE V++ +P + + Sbjct: 325 TGNKDIIMVDHMRKMKNNAIVCNIGHFDNEIDMLGLETYPGVKRITIKPQTDRWVFPDTN 384 Query: 317 KTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLL--ENHRKMSPKVYMLPDEID 374 + +LAEGRL+NL GHP +M SF Q+ A L L ++ K KVY+LP +D Sbjct: 385 SGIIVLAEGRLMNLGCATGHPSFVMSCSFTNQVIAQLELWNEKSSGKYEKKVYVLPKHLD 444 Query: 375 ERVARMKLDSLGVKIDELTEKQRRYL 400 E+VA + L LG K+ +L++ Q Y+ Sbjct: 445 EKVAALHLGKLGAKLTKLSKDQADYI 470emb|CAB09795| (Z97059) S-adenosyl-L-homocysteine hydrolase [Arabidopsis thaliana] Length = 467 Score = 228 bits (575), Expect = 7e-59 Identities = 146/446 (32%), Positives = 218/446 (48%), Gaps = 49/446 (10%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G +++ MP L E+ +P G + S+H+ +TA L TL+ LGA+V Sbjct: 7 GRLELELAEVEMPGLMACRTEFGPSQPFKGARITGSLHMTIQTAVLIETLTALGAQVRWC 66 Query: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIYRENLMKVLD----ERPDFIIDDGGDLT 119 N STQD A+ V+A + Y + LD PD I+DDGGD T Sbjct: 67 SCNIFSTQDHARAAIARDSAAVFAWKGETLQEYWWCTERALDWGPGGGPDLIVDDGGDAT 126 Query: 120 VISH--TEREEVLEN---------------------------------------LKGVSE 138 ++ H + EE+ E L GVSE Sbjct: 127 LLIHEGVKAEEIFEKTGQVPDPTSTDNPEFQIVLSIIKEGLQVDPKKYHKMKERLVGVSE 186 Query: 139 ETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQSTWDAIMRNTNLLVAGKN 198 ETTTGV+RL +++ G L P I VNDS K FDN YG S D +MR T++++AGK Sbjct: 187 ETTTGVKRLYQMQQNGTLLFPAINVNDSVTKSKFDNLYGCRHSLPDGLMRATDVMIAGKV 246 Query: 199 VVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGFTVMPMKEAVKIADFVITA 258 V+ GYG VIVTE+DP+ A++A+M+G V+ +++ V AD +T Sbjct: 247 AVICGYGDVGKGCAAAMKTAGARVIVTEIDPICALQALMEGLQVLTLEDVVSEADIFVTT 306 Query: 259 SGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEI-AVEKFEARPNVTGYTLENGK 317 +GN D++ + + +K+ A++ N GHF+ EI + LE V++ +P + K Sbjct: 307 TGNKDIIMVDHMRKMKNNAIVCNIGHFDNEIDMLGLETYPGVKRITIKPQTDRWVFPETK 366 Query: 318 T-VFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHR--KMSPKVYMLPDEID 374 + +LA+GRL+NL GHP +M SF Q+ A L L K KVY+LP +D Sbjct: 367 AGIIVLAQGRLMNLGCATGHPSFVMSCSFTNQVIAQLELWNEKASGKYEKKVYVLPKHLD 426 Query: 375 ERVARMKLDSLGVKIDELTEKQRRYL 400 E+VA + L LG ++ +L++ Q Y+ Sbjct: 427 EKVALLHLGKLGARLRKLSKDQSDYV 452emb|CAB43223.1| (AL049954) hypothetical protein [Homo sapiens] Length = 597 Score = 227 bits (573), Expect = 1e-58 Identities = 139/401 (34%), Positives = 212/401 (52%), Gaps = 5/401 (1%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G +I + M L + + EKPL+G + H+ A+TA L TL LGA+ + Sbjct: 183 GRREIEIAEQDMSALISLRKRAQGEKPLAGAKIVGCTHITAQTAVLIETLCALGAQCRWS 242 Query: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIYR---ENLMKVLDERPDFIIDDGGDLTV 120 N STQ++VA AL G+ V+A + E + + + + + + I+DDGGDLT Sbjct: 243 ACNIYSTQNEVAAALAEAGVAVFAWKGESEDDFWWCIDRCVNMDGWQANMILDDGGDLTH 302 Query: 121 ISHTEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQ 180 + + V + ++G+ EE+ TGV RL L + GKL VP + VNDS K FDN Y + Sbjct: 303 WVYKKYPNVFKKIRGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRE 362 Query: 181 STWDAIMRNTNLLVAGKNVVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGF 240 S D + R T+++ GK VVV GYG V +TE+DP+ A++A MDGF Sbjct: 363 SILDGLKRTTDVMFGGKQVVVCGYGEVGKGCCAALKALGAIVYITEIDPICALQACMDGF 422 Query: 241 TVMPMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVE 300 V+ + E ++ D VIT +GN +V+++E + +K+ ++ N GH N EI V L + Sbjct: 423 RVVKLNEVIRQVDVVITCTGNKNVVTREHLDRMKNSCIVCNMGHSNTEIDVTSLRTPELT 482 Query: 301 KFEARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLE-NH 359 R V +GK V LLAEGRL+NL+ P ++ ++ Q A++ L Sbjct: 483 WERVRSQVDHVIWPDGKRVVLLAEGRLLNLSCST-VPTFVLSITATTQALALIELYNAPE 541 Query: 360 RKMSPKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYL 400 + VY+LP ++DE VA + L S + ELT+ Q +YL Sbjct: 542 GRYKQDVYLLPKKMDEYVASLHLPSFDAHLTELTDDQAKYL 582ref|NP_006612.1|| S-adenosylhomocysteine hydrolase-like 1 >gi|6094223|sp|O43865|SAH2_HUMAN PUTATIVE ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE) >gi|2852125 (U82761) S-adenosyl homocysteine hydrolase homolog [Homo sapiens] Length = 500 Score = 227 bits (573), Expect = 1e-58 Identities = 139/401 (34%), Positives = 212/401 (52%), Gaps = 5/401 (1%) Query: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63 G +I + M L + + EKPL+G + H+ A+TA L TL LGA+ + Sbjct: 86 GRREIEIAEQDMSALISLRKRAQGEKPLAGAKIVGCTHITAQTAVLIETLCALGAQCRWS 145 Query: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIYR---ENLMKVLDERPDFIIDDGGDLTV 120 N STQ++VA AL G+ V+A + E + + + + + + I+DDGGDLT Sbjct: 146 ACNIYSTQNEVAAALAEAGVAVFAWKGESEDDFWWCIDRCVNMDGWQANMILDDGGDLTH 205 Query: 121 ISHTEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQ 180 + + V + ++G+ EE+ TGV RL L + GKL VP + VNDS K FDN Y + Sbjct: 206 WVYKKYPNVFKKIRGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRE 265 Query: 181 STWDAIMRNTNLLVAGKNVVVAGYGWCXXXXXXXXXXXXXXVIVTEVDPVKAVEAIMDGF 240 S D + R T+++ GK VVV GYG V +TE+DP+ A++A MDGF Sbjct: 266 SILDGLKRTTDVMFGGKQVVVCGYGEVGKGCCAALKALGAIVYITEIDPICALQACMDGF 325 Query: 241 TVMPMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVE 300 V+ + E ++ D VIT +GN +V+++E + +K+ ++ N GH N EI V L + Sbjct: 326 RVVKLNEVIRQVDVVITCTGNKNVVTREHLDRMKNSCIVCNMGHSNTEIDVTSLRTPELT 385 Query: 301 KFEARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLE-NH 359 R V +GK V LLAEGRL+NL+ P ++ ++ Q A++ L Sbjct: 386 WERVRSQVDHVIWPDGKRVVLLAEGRLLNLSCST-VPTFVLSITATTQALALIELYNAPE 444 Query: 360 RKMSPKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYL 400 + VY+LP ++DE VA + L S + ELT+ Q +YL Sbjct: 445 GRYKQDVYLLPKKMDEYVASLHLPSFDAHLTELTDDQAKYL 485Database: Non-redundant GenBank CDS translations+PDB+SwissProt+SPupdate+PIR Posted date: Jan 12, 2000 2:26 PM Number of letters in database: 136,724,657 Number of sequences in database: 444,417 Lambda K H 0.317 0.135 0.377 Gapped Lambda K H 0.270 0.0470 0.230 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 99282593 Number of Sequences: 444417 Number of extensions: 3910176 Number of successful extensions: 10424 Number of sequences better than 10.0: 78 Number of HSP's better than 10.0 without gapping: 67 Number of HSP's successfully gapped in prelim test: 11 Number of HSP's that attempted gapping in prelim test: 10184 Number of HSP's gapped (non-prelim): 112 length of query: 404 length of database: 136,724,657 effective HSP length: 59 effective length of query: 345 effective length of database: 110,504,054 effective search space: 38123898630 effective search space used: 38123898630 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.8 bits) X3: 64 (24.9 bits) S1: 41 (21.6 bits) S2: 71 (32.1 bits)