Score E
Sequences producing significant alignments: (bits) Value
gi|2983420 (AE000712) hypothetical protein [Aquifex aeolicus] 385 e-106
dbj|BAA30959.1| (AP000007) 221aa long hypothetical protein ... 175 3e-43
emb|CAB49315.1| (AJ248284) hypothetical protein [Pyrococcus... 172 2e-42
gi|2648608 (AE000970) conserved hypothetical protein [Archa... 118 2e-26
pir||F64418 hypothetical protein MJ0950 - Methanococcus jan... 118 4e-26
gi|2621292 (AE000811) conserved protein [Methanobacterium t... 113 1e-24
dbj|BAA80564.1| (AP000062) 217aa long hypothetical protein ... 107 6e-23
dbj|BAA29800| (AP000003) 161aa long hypothetical protein [P... 34 0.69
sp|P27653|C1TC_RAT C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASM... 32 2.7
sp|O97798|IL10_TRIVU INTERLEUKIN-10 PRECURSOR (IL-10) (CYTO... 32 3.5
pir||A35367 C1-tetrahydrofolate synthase - rat 32 3.5
dbj|BAA80611.1| (AP000062) 650aa long hypothetical protein ... 32 4.6
gi|2983859 (AE000742) general secretion pathway protein E [... 32 4.6
emb|CAB50423.1| (AJ248287) hypothetical protein [Pyrococcus... 31 6.0
emb|CAB49524.1| (AJ248284) hypothetical protein [Pyrococcus... 31 7.9
gi|2983073 (AE000688) putative protein [Aquifex aeolicus] 31 7.9
gi|2650333 (AE001084) conserved hypothetical protein [Archa... 31 7.9
gi|2983420 (AE000712) hypothetical protein [Aquifex aeolicus]
Length = 192
Score = 385 bits (979), Expect = e-106
Identities = 192/192 (100%), Positives = 192/192 (100%)
Query: 1 MDVFVLDTSVFTNPEIYRTFEEDQRGAMETFIHLALNSRAEFYMPTSVYTEMRKIMDVGE 60
MDVFVLDTSVFTNPEIYRTFEEDQRGAMETFIHLALNSRAEFYMPTSVYTEMRKIMDVGE
Sbjct: 1 MDVFVLDTSVFTNPEIYRTFEEDQRGAMETFIHLALNSRAEFYMPTSVYTEMRKIMDVGE 60
Query: 61 LWAEFEMVVKIRSPRRFQLTVPADFLYEFIEELRYRINKGLRIAEEHTREASGCEDVGKL 120
LWAEFEMVVKIRSPRRFQLTVPADFLYEFIEELRYRINKGLRIAEEHTREASGCEDVGKL
Sbjct: 61 LWAEFEMVVKIRSPRRFQLTVPADFLYEFIEELRYRINKGLRIAEEHTREASGCEDVGKL 120
Query: 121 IARLREKYREALRQGILDSKEDVDVLLLAYELDGVLVSADEGLRTWADKIGIKLIDPKNF 180
IARLREKYREALRQGILDSKEDVDVLLLAYELDGVLVSADEGLRTWADKIGIKLIDPKNF
Sbjct: 121 IARLREKYREALRQGILDSKEDVDVLLLAYELDGVLVSADEGLRTWADKIGIKLIDPKNF 180
Query: 181 KNILESLVRHRF 192
KNILESLVRHRF
Sbjct: 181 KNILESLVRHRF 192
dbj|BAA30959.1| (AP000007) 221aa long hypothetical protein [Pyrococcus horikoshii]
Length = 221
Score = 175 bits (438), Expect = 3e-43
Identities = 86/188 (45%), Positives = 128/188 (67%), Gaps = 3/188 (1%)
Query: 4 FVLDTSVFTNPEIYRTFEEDQRGAMETFIHLALN--SRAEFYMPTSVYTEMRKIMDVGEL 61
FVLDTS+F NP++ + F E AM+TF+H A N + EFYMP +Y E+ ++ E+
Sbjct: 21 FVLDTSIFVNPDVRKKFGETPTEAMKTFLHYAENLFGKVEFYMPPGIYRELMHFVEEEEV 80
Query: 62 WAEFEMVVKIRSPRRFQLTVPADFLYEFIEELRYRINKGLRIAEEHTREAS-GCEDVGKL 120
+ E+ + + P + +PA +YE IE++R R++KGLR+AE+ RE+ +V K+
Sbjct: 81 SPDIELYIIKKPPNVHDIKIPAFVVYELIEDIRRRVDKGLRVAEKAVRESVIDTSNVDKI 140
Query: 121 IARLREKYREALRQGILDSKEDVDVLLLAYELDGVLVSADEGLRTWADKIGIKLIDPKNF 180
I +LR YR+ALR+GILDSKED +++LLA E+DG++VSAD G+ TWA+K+GIK +D F
Sbjct: 141 IQKLRRNYRKALREGILDSKEDFELILLAKEIDGIIVSADVGILTWAEKMGIKWVDAFKF 200
Query: 181 KNILESLV 188
K +L LV
Sbjct: 201 KEVLSELV 208
emb|CAB49315.1| (AJ248284) hypothetical protein [Pyrococcus abyssi]
Length = 204
Score = 172 bits (431), Expect = 2e-42
Identities = 87/188 (46%), Positives = 127/188 (67%), Gaps = 3/188 (1%)
Query: 4 FVLDTSVFTNPEIYRTFEEDQRGAMETFIHLA--LNSRAEFYMPTSVYTEMRKIMDVGEL 61
FVLDTS+F NP++ + F E AM+TF+ A L EFYMP +Y E+ ++ E+
Sbjct: 4 FVLDTSIFVNPDVRKKFGETPTKAMKTFLKYAESLFGHVEFYMPPGIYREVMHFVEEEEV 63
Query: 62 WAEFEMVVKIRSPRRFQLTVPADFLYEFIEELRYRINKGLRIAEEHTREAS-GCEDVGKL 120
+ E+ + + P + +PA +YE IE++R R++KGLR+AE+ RE+ +V K+
Sbjct: 64 SPDIELYIIKKPPNVHDIKIPAFVVYELIEDIRRRVDKGLRVAEKAVRESVIDTSNVDKI 123
Query: 121 IARLREKYREALRQGILDSKEDVDVLLLAYELDGVLVSADEGLRTWADKIGIKLIDPKNF 180
I +LR YR+ALR+GILDSKED +++LLA ELDG++VSAD G+ TWA+K+GIK +D F
Sbjct: 124 IQKLRRNYRKALREGILDSKEDFELILLAKELDGIIVSADVGILTWAEKMGIKWVDAFKF 183
Query: 181 KNILESLV 188
K +LE LV
Sbjct: 184 KEVLEELV 191
gi|2648608 (AE000970) conserved hypothetical protein [Archaeoglobus fulgidus]
Length = 227
Score = 118 bits (294), Expect = 2e-26
Identities = 67/207 (32%), Positives = 117/207 (56%), Gaps = 21/207 (10%)
Query: 4 FVLDTSVFTNP-----EIYRTFEEDQRGAMETFIHLALNSRAEFYMP-TSVYTEMRKIMD 57
FVLDT+ T+ E Y + E ++ L Y+P SVYTE+ +
Sbjct: 5 FVLDTTAITDAGLRIKEGYESLCESAAEVLDLIALARLKLDISCYIPYPSVYTELTSFLK 64
Query: 58 V----GELWAEFEMVVKIRSPRRFQLTVPADFLYEFIEELRYRINKGLRIAEEHTREASG 113
E++ + + + ++P R+++ +PA YE+I +R ++N+G R+AEE+ E+S
Sbjct: 65 RYGCDEEIFTKLDTWLVKKTPNRYEVKIPAAIFYEYIITVRQKMNRGRRLAEEYILESSA 124
Query: 114 C-----------EDVGKLIARLREKYREALRQGILDSKEDVDVLLLAYELDGVLVSADEG 162
E++G LI++ R+KYR +RQGILDS D+DVLLLA EL+ +VS+D G
Sbjct: 125 ITAKLEDKSKIEEEIGALISKFRDKYRAVMRQGILDSAPDLDVLLLAKELEAGVVSSDAG 184
Query: 163 LRTWADKIGIKLIDPKNFKNILESLVR 189
+R W++++G++ ++ F +L+ ++
Sbjct: 185 IRKWSERLGLRFVEAAKFPRMLKEYLK 211
pir||F64418 hypothetical protein MJ0950 - Methanococcus jannaschii >gi|1591617
(U67538) conserved hypothetical protein [Methanococcus
jannaschii]
Length = 233
Score = 118 bits (292), Expect = 4e-26
Identities = 69/217 (31%), Positives = 117/217 (53%), Gaps = 32/217 (14%)
Query: 4 FVLDTSVFTNPEI-----YRTFEEDQRGAMETFIHLALNSRAEFYMP-TSVYTEMRKIMD 57
F LDTS FT P + +T E M+ + ++P +VY E+ ++
Sbjct: 10 FCLDTSAFTEPSVRKALGVKTVTELTDKVMDLIAEARIKLNISCHIPYPTVYNELMGFLE 69
Query: 58 VGELWAEFEMVVKI------RSPRRFQLTVPADFLYEFIEELRYRINKGLRIAEEHTREA 111
+++VK+ ++P R+++ +P++ YE++++LR RINKG+RI EEH +A
Sbjct: 70 NEN--CPRDVIVKVDTWLVKKTPNRYEIKIPSEIFYEYVKDLRERINKGMRIGEEHIIKA 127
Query: 112 SGC--------------EDVGKLIAR----LREKYREALRQGILDSKEDVDVLLLAYELD 153
+ E + K++++ R KYR ALR G LDS D+DVLLLA ELD
Sbjct: 128 TDMVYELSKKHPEMGKNEIINKVLSKTINTFRNKYRSALRVGTLDSAPDLDVLLLAKELD 187
Query: 154 GVLVSADEGLRTWADKIGIKLIDPKNFKNILESLVRH 190
+V++D G+ WA ++G++ +D +F +LE ++H
Sbjct: 188 AAVVASDGGIEKWAQRLGLRFVDASDFPFMLEEYLKH 224
gi|2621292 (AE000811) conserved protein [Methanobacterium thermoautotrophicum]
Length = 220
Score = 113 bits (280), Expect = 1e-24
Identities = 69/212 (32%), Positives = 114/212 (53%), Gaps = 25/212 (11%)
Query: 4 FVLDTSVFTNPEIYRTFEE-DQRGAMETFIHLALNSRAEF----YMPTSVYTEMRKIMD- 57
FVLDT+ FT+ ++ + D +++ + L SR + +MP Y E M
Sbjct: 7 FVLDTTAFTDNQLRELLGDGDLNLSVDRMLDLIARSRIKLNISCHMPPITYKEFTDYMTR 66
Query: 58 ---VGELWAEFEMVVKIRSPRRFQLTVPADFLYEFIEELRYRINKGLRIAEEHTREAS-- 112
E + E + ++P R+ +P+ YE++ ++R R+NKGLRI+E EA
Sbjct: 67 YDCPEETLIKAETWIVKKTPNRYDTQIPSQIFYEYVHDIRERMNKGLRISETLLWEAGIQ 126
Query: 113 --------------GCEDVGKLIARLREKYREALRQGILDSKEDVDVLLLAYELDGVLVS 158
E +GK I LR+KYR ALR+G LDS D+DVLLLA EL +V+
Sbjct: 127 SIIMASRDVKKTEIESEVLGKAIKDLRKKYRSALRKGTLDSAPDLDVLLLAKELGAGVVA 186
Query: 159 ADEGLRTWADKIGIKLIDPKNFKNILESLVRH 190
AD+G+R WA+++G++ ++ +F +L+ +++
Sbjct: 187 ADDGIRVWAERLGLRFLNATSFPKMLKEYLKY 218
dbj|BAA80564.1| (AP000062) 217aa long hypothetical protein [Aeropyrum pernix]
Length = 217
Score = 107 bits (265), Expect = 6e-23
Identities = 68/185 (36%), Positives = 103/185 (54%), Gaps = 11/185 (5%)
Query: 3 VFVLDTSVFTNPEIY-----RTFEEDQRGAMETFIHLALNSRAEFYMPTSVYTEMRKIMD 57
V V DT++FT+ ++ R+ EE R M + A Y+ SV E+ + M
Sbjct: 15 VVVADTTMFTDAKLREVLGARSLEEAAR-IMARILARASRMGLTVYITPSVRAEIERFML 73
Query: 58 VGELW----AEFEMVVKIRSPRRFQLTVPADFLYEFIEELRYRINKGLRIAEEHTREASG 113
+ A V+++ P +L +PA ++E +R R++KGLR+AE+H R A
Sbjct: 74 GNGVHPTTIARLMAWVRVKPPTTHELRLPAAMFRRYVETVRARLDKGLRVAEDHVRRALR 133
Query: 114 CEDV-GKLIARLREKYREALRQGILDSKEDVDVLLLAYELDGVLVSADEGLRTWADKIGI 172
D G ++ LREKYRE R+G+LDS EDVD LLLA EL +V++DEGLR A+ +G+
Sbjct: 134 SRDEEGDIVRSLREKYREYTRKGMLDSVEDVDTLLLALELGAAIVTSDEGLRRAAEDLGL 193
Query: 173 KLIDP 177
++ P
Sbjct: 194 TVLTP 198
dbj|BAA29800| (AP000003) 161aa long hypothetical protein [Pyrococcus horikoshii]
Length = 161
Score = 34.4 bits (77), Expect = 0.69
Identities = 17/54 (31%), Positives = 32/54 (58%), Gaps = 3/54 (5%)
Query: 139 SKEDVDVLLLAYELDGVLVSADEGLRTWADKIGIKLIDPKNFKNILESLVRHRF 192
SK D++VL LAYEL G + S D ++ A +G++ + K ++ +++ R+
Sbjct: 79 SKADIEVLALAYELKGEIFSDDYNVQNIASLLGLRF---RTLKRGIKKVIKWRY 129
sp|P27653|C1TC_RAT C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC (C1-THF SYNTHASE)
[INCLUDES: METHYLENETETRAHYDROFOLATE DEHYDROGENASE ;
METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE ;
FORMYLTETRAHYDROFOLATE SYNTHETASE ] >gi|901850 (J05519)
C1-tetrahydrofolate synthase [Rattus norvegicus]
Length = 935
Score = 32.5 bits (72), Expect = 2.7
Identities = 23/91 (25%), Positives = 44/91 (48%), Gaps = 5/91 (5%)
Query: 90 IEELRYRINKGLRIAEEHTREASGCEDVGKLIARLREKYREALRQGILDSKEDVDVLLLA 149
+E++R R+ K + +A E CED+G + L ++A++ ++ + E V + A
Sbjct: 579 LEDMRARLGK-MVVASSKKGEPISCEDLG-VSGALTVLMKDAIKPNLMQTLEGTPVFVHA 636
Query: 150 YELDGVLVSADEGLRTWADKIGIKLIDPKNF 180
+ A AD+I +KL+ P+ F
Sbjct: 637 GPFANI---AHGNSSIIADRIALKLVGPEGF 664
sp|O97798|IL10_TRIVU INTERLEUKIN-10 PRECURSOR (IL-10) (CYTOKINE SYNTHESIS INHIBITORY
FACTOR) (CSIF) >gi|4103608|gb|AAD01799| (AF026277)
interleukin-10 [Trichosurus vulpecula]
Length = 174
Score = 32.1 bits (71), Expect = 3.5
Identities = 13/49 (26%), Positives = 25/49 (50%)
Query: 99 KGLRIAEEHTREASGCEDVGKLIARLREKYREALRQGILDSKEDVDVLL 147
K LR+ + CED +++ ++R Y+E QG+ + D D+ +
Sbjct: 113 KALRLRLKRCHRFLPCEDNSRVVKQVRNTYKELQEQGVYKAMGDFDIFI 161
pir||A35367 C1-tetrahydrofolate synthase - rat
Length = 935
Score = 32.1 bits (71), Expect = 3.5
Identities = 23/91 (25%), Positives = 44/91 (48%), Gaps = 5/91 (5%)
Query: 90 IEELRYRINKGLRIAEEHTREASGCEDVGKLIARLREKYREALRQGILDSKEDVDVLLLA 149
+E++R R+ K + +A E CED+G + L ++A++ ++ + E V + A
Sbjct: 579 LEDMRARLGK-MVVASSKKGEPISCEDLG-VQGALTVLMKDAIKPNLMQTLEGTPVFVHA 636
Query: 150 YELDGVLVSADEGLRTWADKIGIKLIDPKNF 180
+ A AD+I +KL+ P+ F
Sbjct: 637 GPFANI---AHGNSSIIADRIALKLVGPERF 664
dbj|BAA80611.1| (AP000062) 650aa long hypothetical protein [Aeropyrum pernix]
Length = 650
Score = 31.7 bits (70), Expect = 4.6
Identities = 20/77 (25%), Positives = 36/77 (45%), Gaps = 4/77 (5%)
Query: 90 IEELRYRINKGLRIAEEHTREASGCEDVGKLIARLREKYREALRQGILDSKE----DVDV 145
+ LR + + +++AEE+ R A + +A ++ EALR KE +V
Sbjct: 283 VARLRKSMEEAMKLAEEYRRRAEELRKAAEAVASAYQEVDEALRSAARGEKEAPVVEVRG 342
Query: 146 LLLAYELDGVLVSADEG 162
+ +L G+ V+A G
Sbjct: 343 KTVLLDLGGLRVAAQRG 359
gi|2983859 (AE000742) general secretion pathway protein E [Aquifex aeolicus]
Length = 469
Score = 31.7 bits (70), Expect = 4.6
Identities = 21/87 (24%), Positives = 43/87 (49%), Gaps = 3/87 (3%)
Query: 58 VGELWAEFEMVVKIRSPRRFQLTVPADFLYEFIEELRYRINKGLR---IAEEHTREASGC 114
+ EL FE +V+ + R + VP ++ + +EELR++ K ++ ++EE +
Sbjct: 1 MSELSESFEYIVEEENERELLVIVPQNYNFFAVEELRFKKGKDVKLKVLSEEEYAKLIQD 60
Query: 115 EDVGKLIARLREKYREALRQGILDSKE 141
G+ + E+ RE + IL ++
Sbjct: 61 RISGENVVLEEEEEREEKSEDILFQRD 87
emb|CAB50423.1| (AJ248287) hypothetical protein [Pyrococcus abyssi]
Length = 357
Score = 31.3 bits (69), Expect = 6.0
Identities = 31/133 (23%), Positives = 63/133 (47%), Gaps = 26/133 (19%)
Query: 76 RFQLTVPADFLYEFIEELRYRINKGLRIAEEHTREASGCED----VGKLIARLREKYREA 131
+F + A+FL + EE+R+++++ L I E+ E G G + + K+ +A
Sbjct: 207 KFNSEMSAEFLEKGFEEMRFKVSE-LEI-EKAVEELDGIVGWLTLYGYIRVTRKVKHEDA 264
Query: 132 LRQGILDSKEDVDVLLLAYELD----------GVLVSADEGLRTWAD-----KIGIKLID 176
+ + + +++ L+L+ EL G+L + G W D + + I+
Sbjct: 265 MEEILREAR-----LILSTELSRLFSYSPRYKGILKAISLGYSRWRDIKDYLTLKLGYIN 319
Query: 177 PKNFKNILESLVR 189
NF ++LE+LV+
Sbjct: 320 DSNFSSLLENLVK 332
emb|CAB49524.1| (AJ248284) hypothetical protein [Pyrococcus abyssi]
Length = 354
Score = 30.9 bits (68), Expect = 7.9
Identities = 35/137 (25%), Positives = 57/137 (41%), Gaps = 28/137 (20%)
Query: 76 RFQLTVPADFLYEFIEELRYRINKGLRIAEEHTREASGCED--------------VGKLI 121
RF DFL + EE+ G+++ EE E D +G
Sbjct: 206 RFNRYQSLDFLRKGFEEV------GIKVEEEELEEVVDELDGIVGWLTLYGYNRYLGLSH 259
Query: 122 ARLREKYREALRQGILDSKEDVDVLLLAYELDGVLVSADEGLRTWAD-KIGIKL-----I 175
+ +K +E ++ IL+ + L YEL + + G W + K ++L I
Sbjct: 260 RKALKKLKEDAKRLILNEFSKLKELSPRYEL--AMKAVASGKHRWKEIKEAVELLEGKRI 317
Query: 176 DPKNFKNILESLVRHRF 192
D KNF N+L +LVR+ +
Sbjct: 318 DDKNFSNVLNNLVRYDY 334
gi|2983073 (AE000688) putative protein [Aquifex aeolicus]
Length = 272
Score = 30.9 bits (68), Expect = 7.9
Identities = 23/83 (27%), Positives = 38/83 (45%), Gaps = 5/83 (6%)
Query: 115 EDVGKLIARLREKYREALRQGILDSKEDVDVLLLAYELDGVLVSADEGLRTWADKI---- 170
E + K+ A R+K R G+ + KE + LL E + + E RTW +K+
Sbjct: 68 EILDKIFAARRKKKRIIEETGVENLKEAIKKLLYGEEGGFLGLGKKEDKRTWEEKVEEFA 127
Query: 171 -GIKLIDPKNFKNILESLVRHRF 192
I+ +D + K+I L+ F
Sbjct: 128 RSIRGVDKRAAKDIAAELLHFTF 150
gi|2650333 (AE001084) conserved hypothetical protein [Archaeoglobus fulgidus]
Length = 102
Score = 30.9 bits (68), Expect = 7.9
Identities = 22/82 (26%), Positives = 42/82 (50%), Gaps = 14/82 (17%)
Query: 115 EDVGKLIARLREKYREAL---------RQGILDSKEDVDVLLLAYELDGVLVSADEGLRT 165
E + +L L+EK+++ + +G LD D+D+L++ + D V + +
Sbjct: 3 EKLLELSRELKEKFKDEIIEIIVFGSYARGDLDEDSDIDILVVVND-DSVEDDLRKAAYS 61
Query: 166 WADKIG----IKLIDPKNFKNI 183
+ KIG +K+ID K F+N+
Sbjct: 62 FIPKIGRLISVKIIDKKTFENM 83
Database: Non-redundant GenBank CDS
translations+PDB+SwissProt+SPupdate+PIR
Posted date: Jan 12, 2000 2:26 PM
Number of letters in database: 136,724,657
Number of sequences in database: 444,417
Lambda K H
0.323 0.141 0.402
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48290727
Number of Sequences: 444417
Number of extensions: 1867731
Number of successful extensions: 4392
Number of sequences better than 10.0: 17
Number of HSP's better than 10.0 without gapping: 9
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 4371
Number of HSP's gapped (non-prelim): 20
length of query: 192
length of database: 136,724,657
effective HSP length: 53
effective length of query: 139
effective length of database: 113,170,556
effective search space: 15730707284
effective search space used: 15730707284
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.9 bits)
S2: 68 (30.9 bits)