Score E
Sequences producing significant alignments: (bits) Value
gi|2983416 (AE000712) malonyl-CoA:Acyl carrier protein tran... 656 0.0
sp|P25715|FABD_ECOLI MALONYL COA-ACYL CARRIER PROTEIN TRANS... 235 5e-61
sp|P43712|FABD_HAEIN MALONYL COA-ACYL CARRIER PROTEIN TRANS... 229 2e-59
sp|O85140|FABD_SALTY MALONYL COA-ACYL CARRIER PROTEIN TRANS... 227 1e-58
emb|CAA74249| (Y13937) putative FabD protein [Bacillus subt... 217 8e-56
gb|AAF11497.1|AE002033_5 (AE002033) malonyl CoA-acyl carrie... 212 3e-54
emb|CAA15164| (AJ235273) MALONYL COA-ACYL CARRIER PROTEIN T... 208 5e-53
gb|AAB94394.1| (U91631) malonyl-CoA:acyl carrier protein tr... 203 1e-51
sp|P71019|FABD_BACSU MALONYL COA-ACYL CARRIER PROTEIN TRANS... 198 4e-50
dbj|BAA85255.1| (AB021978) malonyl Coenzyme A-acyl carrier ... 197 1e-49
gb|AAD35880.1|AE001747_23 (AE001747) malonyl CoA-acyl carri... 196 2e-49
gb|AAF08794.1|AF184956_1 (AF184956) FenF [Bacillus subtilis] 180 2e-44
gi|840626 (L42526) transacylase [Bacillus subtilis] 178 5e-44
gb|AAD18446| (AE001614) Malonyl Acyl Carrier Transcyclase [... 173 2e-42
gb|AAD40110.1|AF155831_4 (AF155831) unknown [Bacillus cereus] 162 3e-39
gb|AAC67831.1| (AE001297) Malonyl CoA-Acyl Carrier Transacy... 159 3e-38
gb|AAF00957.1|AF183408_5 (AF183408) McyG [Microcystis aerug... 156 3e-37
emb|CAB45522.1| (AJ007046) [acyl-carrier protein] S-malonyl... 155 3e-37
gb|AAC16926.2| (AC002338) putative malonyl-CoA:Acyl carrier... 149 3e-35
gb|AAD07158.1| (AE000530) malonyl coenzyme A-acyl carrier p... 147 1e-34
gi|4154593 (AE001447) MALONYL COA-ACYL CARRIER PROTEIN TRAN... 146 2e-34
emb|CAB13582| (Z99112) pksC [Bacillus subtilis] >gi|2634093... 146 2e-34
sp|P73242|FABD_SYNY3 MALONYL COA-ACYL CARRIER PROTEIN TRANS... 143 1e-33
gi|2558838 (AF016585) polyketide synthase modules 1 and 2 [... 143 2e-33
emb|CAB13584| (Z99112) pksE [Bacillus subtilis] >gi|2634095... 140 2e-32
emb|CAB41041.1| (AJ132222) polyketide synthase [Streptomyce... 139 4e-32
emb|CAA17262| (AL021899) pks12 [Mycobacterium tuberculosis] 138 8e-32
emb|CAB06605| (Z84725) pks6 [Mycobacterium tuberculosis] 138 8e-32
gi|2558839 (AF016585) polyketide synthase module 3 [Strepto... 137 1e-31
emb|CAA11039| (AJ223012) rifamycin polyketide synthase, typ... 134 1e-30
emb|CAB09098| (Z95617) pks8 [Mycobacterium tuberculosis] 133 2e-30
gi|2529418 (U73935) unknown [Shewanella sp. SCRC-2738] 132 3e-30
gb|AAF19814.1|AF188287_6 (AF188287) MtaF [Stigmatella auran... 129 2e-29
gb|AAF19812.1|AF188287_4 (AF188287) MtaD [Stigmatella auran... 129 2e-29
dbj|BAA84479.1| (AB032367) type I polyketide synthase AVES ... 129 2e-29
gi|2570220 (AF016890) heterocyst glycolipid synthase [Nosto... 128 7e-29
dbj|BAA76543.1| (AB017641) polyketide synthase [Micromonosp... 127 9e-29
emb|CAB52353.1| (AL109747) putative multi-domain beta keto-... 125 5e-28
emb|CAB09100| (Z95617) pks9 [Mycobacterium tuberculosis] 125 5e-28
gi|2624949 (AF007101) PKS module 2 [Streptomyces hygroscopi... 123 2e-27
gi|2555096 (AF015823) VenA [Streptomyces venezuelae] 122 3e-27
emb|CAA87011| (Z46913) polyketide synthase [Streptomyces am... 122 4e-27
emb|CAB06103| (Z83858) pks1 [Mycobacterium tuberculosis] 121 7e-27
pir||S73075 pks002c protein - Mycobacterium tuberculosis (f... 121 7e-27
emb|CAA11035| (AJ223012) rifamycin polyketide synthase, typ... 120 1e-26
gi|2317864 (U78289) tylactone synthase module 7 [Streptomyc... 116 2e-25
emb|CAA60462| (X86780) polyketide synthase [Streptomyces hy... 114 9e-25
gi|2558842 (AF016585) polyketide synthase module 7 [Strepto... 113 2e-24
emb|CAA18261.1| (AL022237) bK1191B2.3 (PUTATIVE novel Acyl ... 111 1e-23
gb|AAD54967.1|AF161721_1 (AF161721) malonyl CoA-acyl carrie... 110 2e-23
gi|2317861 (U78289) tylactone synthase module 3 [Streptomyc... 110 2e-23
gb|AAF00958.1|AF183408_6 (AF183408) McyE [Microcystis aerug... 109 2e-23
gi|4106861 (AF098795) type I polyketide synthase; Cfa7 [Pse... 109 2e-23
gi|3800834 (AF079138) type I polyketide synthase PikAI [Str... 108 9e-23
gi|2240018 (U95087) MdcH [Klebsiella pneumoniae] 107 1e-22
emb|CAB41040.1| (AJ132221) polyketide synthase [Streptomyce... 106 2e-22
gi|1314845 (U56096) MdcG [Klebsiella pneumoniae] 106 2e-22
gb|AAF00959.1|AF183408_7 (AF183408) McyD [Microcystis aerug... 105 5e-22
dbj|BAA36210.1| (AB017138) epsilon subunit of malonate deca... 105 6e-22
dbj|BAA84478.1| (AB032367) type I polyketide synthase AVES ... 104 1e-21
gi|2792315 (AF040570) polyketide synthase [Amycolatopsis me... 102 3e-21
emb|CAA11036| (AJ223012) rifamycin polyketide synthase, typ... 102 3e-21
dbj|BAA84475.1| (AB032367) type I polyketide synthase AVES ... 102 4e-21
gb|AAC38076.1| (AF081920) polyketide synthase type I; PltC ... 102 4e-21
gb|AAF15892.2|AF204805_2 (AF204805) NosB [Nostoc sp. GSV224] 101 9e-21
gi|4106860 (AF098795) type I polyketide synthase; Cfa6 [Pse... 101 9e-21
gi|870806 (L43074) putative [Streptomyces glaucescens] 101 9e-21
pir||A57356 acyl-CoA carrier protein malonyltransferase - S... 100 2e-20
sp|Q03131|ERY1_SACER ERYTHRONOLIDE SYNTHASE, MODULES 1 AND ... 100 3e-20
gi|152692 (M63676) ORF1 encoding modules 1 & 2 for 6-deoxye... 100 3e-20
dbj|BAA76353.1| (AB025101) malonyl-CoA-ACP acyltransferase ... 99 5e-20
emb|CAA72713| (Y11985) orsellinic acid synthase [Streptomyc... 99 6e-20
emb|CAB06632| (Z85982) pks7 [Mycobacterium tuberculosis] 99 6e-20
gi|2624948 (AF007101) PKS module 1 [Streptomyces hygroscopi... 98 1e-19
dbj|BAA84474.1| (AB032367) type I polyketide synthase AVES ... 97 2e-19
emb|CAA60459| (X86780) polyketide synthase [Streptomyces hy... 97 2e-19
pir||S73015 polyketide synthase pksF - Mycobacterium leprae... 97 2e-19
sp|Q07017|OL56_STRAT OLEANDOMYCIN POLYKETIDE SYNTHASE, MODU... 96 3e-19
gi|4092069 (AF082993) type I fatty acid synthase [Cryptospo... 95 7e-19
sp|Q10501|FABD_MYCTU MALONYL COA-ACYL CARRIER PROTEIN TRANS... 94 2e-18
gi|2624950 (AF007101) PKS module 3 [Streptomyces hygroscopi... 93 3e-18
pir||S73021 polyketide synthase pksE - Mycobacterium leprae... 93 3e-18
gi|3800836 (AF079138) type I polyketide synthase PikAIII [S... 92 4e-18
gi|2558840 (AF016585) polyketide synthase modules 4 and 5 [... 92 4e-18
emb|CAA60460| (X86780) polyketide synthase [Streptomyces hy... 92 4e-18
gi|3935136 (U88833) polyketide synthase homolog [Streptomyc... 92 8e-18
gi|3800835 (AF079138) type I polyketide synthase PikAII [St... 92 8e-18
gi|2792316 (AF040570) polyketide synthase [Amycolatopsis me... 92 8e-18
emb|CAA11037| (AJ223012) rifamycin polyketide synthase, typ... 92 8e-18
gi|3800837 (AF079138) type I polyketide synthase PikAIV [St... 91 1e-17
emb|CAA73127| (Y12527) HMWP1 protein [Yersinia enterocolitica] 91 1e-17
gi|152695 (M63677) ORF3 encoding modules 5 & 6 for 6-deoxye... 90 2e-17
gb|AAC69588.1| (AF091251) Ybt peptide/polyketide synthetase... 90 3e-17
gi|1109869 (U41541) Similar to polyketide synthase. [Caenor... 89 4e-17
pir||S18954 fix23-2 protein - Rhizobium meliloti >gi|46272|... 89 5e-17
emb|CAA44448| (X62569) 6-deoxyerythronolide B synthase II ... 89 7e-17
sp|Q03132|ERY2_SACER ERYTHRONOLIDE SYNTHASE, MODULES 3 AND ... 89 7e-17
gi|2624951 (AF007101) PKS module 4 [Streptomyces hygroscopi... 88 1e-16
pir||S23070 6-deoxyerythronolide B synthase II - Saccharopo... 88 1e-16
gb|AAC38075.1| (AF081920) polyketide synthase type I; PltB ... 87 1e-16
gi|2983416 (AE000712) malonyl-CoA:Acyl carrier protein transacylase [Aquifex
aeolicus]
Length = 326
Score = 656 bits (1673), Expect = 0.0
Identities = 326/326 (100%), Positives = 326/326 (100%)
Query: 1 MDATLIIGLLSKDMGKLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLDDI 60
MDATLIIGLLSKDMGKLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLDDI
Sbjct: 1 MDATLIIGLLSKDMGKLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLDDI 60
Query: 61 VDVMFKGPEEKLNKTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGG 120
VDVMFKGPEEKLNKTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGG
Sbjct: 61 VDVMFKGPEEKLNKTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGG 120
Query: 121 IDVQLGARLTYYRGKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSS 180
IDVQLGARLTYYRGKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSS
Sbjct: 121 IDVQLGARLTYYRGKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSS 180
Query: 181 TQTVISGEKPAVEKAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIK 240
TQTVISGEKPAVEKAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIK
Sbjct: 181 TQTVISGEKPAVEKAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIK 240
Query: 241 IPLVQNYTAKAHTMAHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLI 300
IPLVQNYTAKAHTMAHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLI
Sbjct: 241 IPLVQNYTAKAHTMAHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLI 300
Query: 301 QQTLPNVRVFNVEKPEDAESVLKAIT 326
QQTLPNVRVFNVEKPEDAESVLKAIT
Sbjct: 301 QQTLPNVRVFNVEKPEDAESVLKAIT 326
sp|P25715|FABD_ECOLI MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE (MCT)
>gi|281876|pir||B41856 [acyl-carrier-protein]
S-malonyltransferase (EC 2.3.1.39) - Escherichia coli
>gi|1431717|pdb|1MLA| Mol_id: 1; Molecule:
Malonyl-Coenzyme A Acyl Carrier Protein Transacylase;
Chain: Null; Synonym: Malonyl-Coa Acp Transacylase;
Engineered: Yes >gi|41364|emb|CAA77658| (Z11565) malonyl
CoA-acyl carrier protein transacylase [Escherichia
coli] >gi|145887 (M87040) malonyl coenzyme A-acyl
carrier protein transacylase [Escherichia coli]
>gi|1651535|dbj|BAA35900| (D90745)
[Acyl-carrier-protein] s-malonyltransferase (EC
2.3.1.39). [Escherichia coli] >gi|1787334 (AE000210)
malonyl-CoA-[acyl-carrier-protein] transacylase
[Escherichia coli]
Length = 309
Score = 235 bits (592), Expect = 5e-61
Identities = 131/311 (42%), Positives = 179/311 (57%), Gaps = 4/311 (1%)
Query: 14 MGKLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLDDIVDVMFKGPEEKLN 73
M + A+VFPGQGSQ VGM + + + +L L + +GP E+LN
Sbjct: 1 MTQFAFVFPGQGSQTVGMLADMAASYPIVEETFAEASAALGYDLWALTQ---QGPAEELN 57
Query: 74 KTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYYR 133
KT TQPAL S+ +Y+ + G P +AGHSLGEY+AL AG ID RL R
Sbjct: 58 KTWQTQPALLTASVALYRVWQQQGGKAPAMMAGHSLGEYSALVCAGVIDFADAVRLVEMR 117
Query: 134 GKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEKPAVE 193
GK+MQEAVPEG GAM AI+ L + +ACE A + VV P N+NS Q VI+G K AVE
Sbjct: 118 GKFMQEAVPEGTGAMAAIIGLDDASIAKACEEAAEGQVVSPVNFNSPGQVVIAGHKEAVE 177
Query: 194 KAAQIAKEMGG-RAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAKAH 252
+A K G RA+PL VSVPSHC+LMKPAAD ++LA+ +P+V N K
Sbjct: 178 RAGAACKAAGAKRALPLPVSVPSHCALMKPAADKLAVELAKITFNAPTVPVVNNVDVKCE 237
Query: 253 TMAHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTLPNVRVFNV 312
T IR+ L Q+++PV+W +SV +M QGV+ E+GP VL+ L ++ + + +
Sbjct: 238 TNGDAIRDALVRQLYNPVQWTKSVEYMAAQGVEHLYEVGPGKVLTGLTKRIVDTLTASAL 297
Query: 313 EKPEDAESVLK 323
+P + L+
Sbjct: 298 NEPSAMAAALE 308
sp|P43712|FABD_HAEIN MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE (MCT)
>gi|1075001|pir||E64051 malonyl coenzyme A-acyl carrier
protein transacylase (fabD) homolog - Haemophilus
influenzae (strain Rd KW20) >gi|1573113 (U32701) malonyl
CoA-acyl carrier protein transacylase (fabD)
[Haemophilus influenzae Rd]
Length = 312
Score = 229 bits (578), Expect = 2e-59
Identities = 134/302 (44%), Positives = 182/302 (59%), Gaps = 7/302 (2%)
Query: 14 MGKLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLDDIVDVMFKGPEEKLN 73
M K A VFPGQGSQ VGM + ++ + +L L +V +GP E+LN
Sbjct: 1 MKKFAMVFPGQGSQTVGMLADLATEYPIVIETFKQASDALGYDLWYLVQ---QGPAEELN 57
Query: 74 KTVYTQPALFAISLGIYKALESMGFP--KPDFVAGHSLGEYTALAVAGGIDVQLGARLTY 131
KT TQPAL A S+ IY+ + FP KP+ +AGHSLGEY+AL AG +D Q +L
Sbjct: 58 KTWQTQPALLAASVAIYRVWKEK-FPQLKPEVMAGHSLGEYSALVCAGVLDFQDAIKLVE 116
Query: 132 YRGKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEKPA 191
RGK MQ+AVPEG GAM AI+ L E + AC++A++ VV N+NS Q VI+G K A
Sbjct: 117 LRGKLMQQAVPEGTGAMYAIIGLDNEAIINACKQAEEGEVVSAVNFNSPGQVVIAGAKAA 176
Query: 192 VEKAAQIAKEMGG-RAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAK 250
VE+AA + KE G RA+PL VSVPSHC+LMKPAA+ + L I I ++ N K
Sbjct: 177 VERAAALCKEAGAKRALPLAVSVPSHCALMKPAAEQLAVTLENIQINTPTISVLNNVDVK 236
Query: 251 AHTMAHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTLPNVRVF 310
A T EIR L Q++SPV+W ++V M + GV E+GP VL+ L ++ + +++
Sbjct: 237 AETEGTEIRTALVRQLYSPVRWTETVEKMAQDGVLVLAEVGPGKVLNGLTKRIVGDLQAI 296
Query: 311 NV 312
+V
Sbjct: 297 SV 298
sp|O85140|FABD_SALTY MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE (MCT) >gi|3282803
(AF044668) malonyl CoA-acyl carrier protein transacylase
[Salmonella typhimurium]
Length = 309
Score = 227 bits (572), Expect = 1e-58
Identities = 128/310 (41%), Positives = 178/310 (57%), Gaps = 4/310 (1%)
Query: 14 MGKLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLDDIVDVMFKGPEEKLN 73
M + A+VFPGQGSQ VGM E + + +L L + +GP E+LN
Sbjct: 1 MTQFAFVFPGQGSQSVGMLAEMAANYPIVEETFAEASAALGYDLWALTQ---QGPAEELN 57
Query: 74 KTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYYR 133
KT TQPAL S+ +++ + G P +AGHSLGEY+AL AG I+ RL R
Sbjct: 58 KTWQTQPALLTASVALWRVWQQQGGKMPALMAGHSLGEYSALVCAGVINFADAVRLVEMR 117
Query: 134 GKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEKPAVE 193
GK+MQEAVPEG G M AI+ L + +ACE + + VV P N+NS Q VI+G K AVE
Sbjct: 118 GKFMQEAVPEGTGGMSAIIGLDDASIAKACEESAEGQVVSPVNFNSPGQVVIAGHKEAVE 177
Query: 194 KAAQIAKEMGG-RAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAKAH 252
+A K G RA+PL VSVPSHC+LMKPAAD ++LA+ +P+V N K
Sbjct: 178 RAGAACKAAGAKRALPLPVSVPSHCALMKPAADKLAVELAKITFSAPTVPVVNNVDVKCE 237
Query: 253 TMAHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTLPNVRVFNV 312
T A IR+ L Q+++PV+W +SV ++ QGV+ E+GP VL+ L ++ + + +
Sbjct: 238 TDAAAIRDALVRQLYNPVQWTKSVEFIAAQGVEHLYEVGPGKVLTGLTKRIVDTLTASAL 297
Query: 313 EKPEDAESVL 322
+P + L
Sbjct: 298 NEPAALSAAL 307
emb|CAA74249| (Y13937) putative FabD protein [Bacillus subtilis]
>gi|2633962|emb|CAB13463| (Z99112) malonyl CoA-acyl
carrier protein transacylase [Bacillus subtilis]
Length = 317
Score = 217 bits (548), Expect = 8e-56
Identities = 120/314 (38%), Positives = 183/314 (58%), Gaps = 6/314 (1%)
Query: 14 MGKLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLDDIVDVMFKGPEEKLN 73
M K+A++FPGQGSQ++GMG E Y+Q + + +L L ++ F+G E+L
Sbjct: 1 MSKIAFLFPGQGSQFIGMGKELYEQVPAAKRLFDEADETLETKLSSLI---FEGDAEELT 57
Query: 74 KTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYYR 133
T QPAL S+ + + + G PDF AGHSLGEY+AL AG + + R
Sbjct: 58 LTYNAQPALLTTSIAVLEKFKESGIT-PDFTAGHSLGEYSALVAAGALSFKDAVYTVRKR 116
Query: 134 GKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVG-VVEPANYNSSTQTVISGEKPAV 192
G++M EAVP G+GAM AIL + E +++ ++ + G +V+ AN N Q VISG V
Sbjct: 117 GEFMNEAVPAGEGAMAAILGMDAEALKQVTDKVTEEGNLVQLANLNCPGQIVISGTAKGV 176
Query: 193 EKAAQIAKEMGG-RAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAKA 251
E A+++AKE G RAIPL+VS P H LMKPAA+ + L I++ +P++ N +A
Sbjct: 177 ELASELAKENGAKRAIPLEVSGPFHSELMKPAAEKLKEVLDACDIKDADVPVISNVSADV 236
Query: 252 HTMAHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTLPNVRVFN 311
T +I+ L Q++SPV++ +S+ + +GV TF+EIGP VLS L+++ ++
Sbjct: 237 MTEKADIKEKLIEQLYSPVRFEESINKLIAEGVTTFIEIGPGKVLSGLVKKVNRRLKTIA 296
Query: 312 VEKPEDAESVLKAI 325
V PE E ++ +
Sbjct: 297 VSDPETIELAIQTL 310
gb|AAF11497.1|AE002033_5 (AE002033) malonyl CoA-acyl carrier protein transacylase
[Deinococcus radiodurans]
Length = 305
Score = 212 bits (535), Expect = 3e-54
Identities = 124/305 (40%), Positives = 176/305 (57%), Gaps = 7/305 (2%)
Query: 16 KLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLDDIVDVMFKGPEEKLNKT 75
K+A +FPGQGS VGMG + +F + + A++ +L + ++ GP + L +T
Sbjct: 5 KIAALFPGQGSHAVGMGADLAGEFPQAGETYAALD----ATLPGLRSLIEGGPLDDLTRT 60
Query: 76 VYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYYRGK 135
QPAL A S+ Y+A ++ P AGHSLGEY+AL AG + ++ RLT RG+
Sbjct: 61 ANQQPALVAASVAAYRAWQAHTGLTPMVAAGHSLGEYSALVAAGVLTLEDALRLTRKRGE 120
Query: 136 YMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEKPAVEKA 195
MQ+AVPEG GAM A++ P V E C A GVV+PAN+N+ TQTVISGEK AV+ A
Sbjct: 121 LMQQAVPEGVGAMSAVMG-DPAVVAEVC--AAQAGVVQPANFNAPTQTVISGEKAAVDAA 177
Query: 196 AQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAKAHTMA 255
+ K G +AIPLKVS P HC+LM+PAA+ +L A P+V N +A+
Sbjct: 178 SAELKTRGLKAIPLKVSAPFHCALMRPAAEGLSAELHAAAYGPYLFPVVANVSAELVDSP 237
Query: 256 HEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTLPNVRVFNVEKP 315
+ L QI V+W ++V + E G + F+E GP +VLS L+++ +P R NV
Sbjct: 238 THTADLLERQITGSVRWVETVQTLAELGTEVFIEFGPGSVLSGLVKRIVPGARTLNVGST 297
Query: 316 EDAES 320
E +
Sbjct: 298 EQVRA 302
emb|CAA15164| (AJ235273) MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE (fabD)
[Rickettsia prowazekii]
Length = 319
Score = 208 bits (524), Expect = 5e-53
Identities = 122/318 (38%), Positives = 176/318 (54%), Gaps = 15/318 (4%)
Query: 16 KLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLDDIVDVMFKGPEEKLNKT 75
K A++FPGQGSQ +GMG +FY + ++ L L DI+ F GP E L T
Sbjct: 7 KTAFIFPGQGSQLIGMGKDFYDNLKPAKETFQIIDEVLNRKLTDII---FNGPSEALTLT 63
Query: 76 VYTQPALFAISLGIY--------KALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGA 127
QPAL A+S+ I K L+S+ D+ AGHSLGEY+AL A I+++ A
Sbjct: 64 TNAQPALMAVSMAIINIIKAETGKNLDSLC----DYAAGHSLGEYSALCSAESINLETTA 119
Query: 128 RLTYYRGKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISG 187
+L + R MQEA PEG GAM A + +P + + E E K + + + AN N Q +ISG
Sbjct: 120 KLLHIRSTSMQEACPEGVGAMAACINIPLQTLVELLEDIKKINLCQIANDNIEGQIIISG 179
Query: 188 EKPAVEKAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNY 247
+ A+ A I K++G +AI LKVS P HCSLMKPA + + L +A I IP++QNY
Sbjct: 180 KVEAINHAISIIKDLGYKAIRLKVSAPFHCSLMKPAEEKMSIALDKAVINKPIIPIIQNY 239
Query: 248 TAKAHTMAHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTLPNV 307
TAK EI+ NL QI V+W +++ + V VEIG NVL+ ++++
Sbjct: 240 TAKPTINPLEIKQNLILQICGRVRWRETLKLFNHLHVTHIVEIGAGNVLTNMLRKINYPY 299
Query: 308 RVFNVEKPEDAESVLKAI 325
++ N+ + ++ L I
Sbjct: 300 KLSNIRNLAELKNFLDNI 317
gb|AAB94394.1| (U91631) malonyl-CoA:acyl carrier protein transacylase [Pseudomonas
aeruginosa]
Length = 312
Score = 203 bits (512), Expect = 1e-51
Identities = 121/301 (40%), Positives = 166/301 (54%), Gaps = 4/301 (1%)
Query: 17 LAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLDDIVDVMFKGPEEKLNKTV 76
LA+VFPGQGSQ +GM E Q D +L L +V GPEE+LN+T
Sbjct: 5 LAFVFPGQGSQSLGMLAELGAQQALVRDTFAEASEALGYDLWALVQ---NGPEERLNQTD 61
Query: 77 YTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYYRGKY 136
TQPA+ +S+ +++ + G +P FVAGHSLGEY+AL A + +L RG+
Sbjct: 62 KTQPAILTVSIALWRLWLAEGGARPAFVAGHSLGEYSALVAAESLAFADAVKLVERRGQL 121
Query: 137 MQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEKPAVEKAA 196
MQ+AVP G+G M AIL L V AC A VV N+N+ Q VI+G AVE+A
Sbjct: 122 MQQAVPAGQGGMAAILGLEDADVLAACAEAAQGEVVSAVNFNAPGQVVIAGAAAAVERAI 181
Query: 197 QIAKEMGG-RAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAKAHTMA 255
+ K G RA+ L VSVPSHC LM+PAA+ F + Q KI LVQN +A
Sbjct: 182 EACKARGAKRAVALPVSVPSHCELMRPAAEQFAASVESLQWQAPKISLVQNVSAAVPADL 241
Query: 256 HEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTLPNVRVFNVEKP 315
+R +L Q++SPV+W +S+ + E+GV VE GP VL+ L ++ + ++
Sbjct: 242 DTLRRDLLAQLYSPVRWVESIQLLAEKGVTELVECGPGKVLAGLNRRCAKGINTHGLDGV 301
Query: 316 E 316
E
Sbjct: 302 E 302
sp|P71019|FABD_BACSU MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE (MCT) >gi|1502420
(U59433) malonyl-CoA:Acyl carrier protein transacylase
[Bacillus subtilis]
Length = 318
Score = 198 bits (499), Expect = 4e-50
Identities = 115/315 (36%), Positives = 177/315 (55%), Gaps = 7/315 (2%)
Query: 14 MGKLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLDDIVDVMFKGPEEKLN 73
M K+A++FPGQGSQ++GMG E Y+Q + + +L L ++ F+G E+L
Sbjct: 1 MSKIAFLFPGQGSQFIGMGKELYEQVPAAKRLFDEADETLETKLSSLI---FEGDAEELT 57
Query: 74 KTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYYR 133
T QPAL S+ + + + G PDF AGHSLGEY+AL AG + + R
Sbjct: 58 LTYNAQPALLTTSIAVLEKFKESGIT-PDFTAGHSLGEYSALVAAGALSFKDAVYTVRKR 116
Query: 134 GKYMQEAVPE-GKGAMVAILKLPPEKVEEACERAKDVG-VVEPANYNSSTQTVISGEKPA 191
G++M EA K AIL + E +++ ++ + G +V+ AN N Q VISG
Sbjct: 117 GEFMNEAGCRLAKEQWAAILGMDAEALKQVTDKVTEEGNLVQLANLNCPGQIVISGTAKG 176
Query: 192 VEKAAQIAKEMGG-RAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAK 250
VE A+++AKE G RAIPL+VS P H LMKPAA+ + L I++ +P++ N +A
Sbjct: 177 VELASELAKENGAKRAIPLEVSGPFHSELMKPAAEKLKEVLDACDIKDADVPVISNVSAD 236
Query: 251 AHTMAHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTLPNVRVF 310
T +I+ L Q++SPV++ +S+ + +GV TF+EIGP VLS L+++ ++
Sbjct: 237 VMTEKADIKEKLIEQLYSPVRFEESINKLIAEGVTTFIEIGPGKVLSGLVKKVNRRLKTI 296
Query: 311 NVEKPEDAESVLKAI 325
V PE E ++ +
Sbjct: 297 AVSDPETIELAIQTL 311
dbj|BAA85255.1| (AB021978) malonyl Coenzyme A-acyl carrier protein transacylase
(malonyl CoA-ACP transacylase (MCT)) homolog [Moritella
marina]
Length = 307
Score = 197 bits (495), Expect = 1e-49
Identities = 116/290 (40%), Positives = 165/290 (56%), Gaps = 4/290 (1%)
Query: 14 MGKLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLDDIVDVMFKGPEEKLN 73
M K A VFPGQGSQ +GM + + H + A + M D+ D++ G E+L+
Sbjct: 1 MSKYAVVFPGQGSQTIGMLADLAAE-HSVVEQTFA--QASEMLGYDLWDLVQHGTVEELS 57
Query: 74 KTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYYR 133
+T TQPAL A S+ +++ + KP VAGHSLGEY+AL AG I + L R
Sbjct: 58 QTHITQPALLATSVALWRIAAAKEDFKPALVAGHSLGEYSALVCAGVIKFEDAIALVELR 117
Query: 134 GKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEKPAVE 193
G+ MQ+AVP+G GAM A++ L + + AC A + VV N+NS Q VI+G K AV
Sbjct: 118 GQLMQQAVPQGIGAMAAVIGLDNDAIIAACATAAEDEVVSAVNFNSPGQVVIAGNKAAVV 177
Query: 194 KAAQIAKEMGGRAI-PLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAKAH 252
+A+++ E G R + PL VSVPSHCSLMKPAAD +L L + I L+ N A
Sbjct: 178 RASELCVEAGARRVMPLPVSVPSHCSLMKPAADELKLALEKVTFNTPVIKLINNVDVAAP 237
Query: 253 TMAHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQ 302
A I++ L Q++ PV+W + + M +Q + E GP VL+ L+++
Sbjct: 238 VDAESIKDALVRQLYMPVRWTEVIEAMAQQEITALYEFGPGKVLTGLVKR 287
gb|AAD35880.1|AE001747_23 (AE001747) malonyl CoA-acyl carrier protein transacylase
[Thermotoga maritima]
Length = 293
Score = 196 bits (494), Expect = 2e-49
Identities = 123/294 (41%), Positives = 166/294 (55%), Gaps = 10/294 (3%)
Query: 18 AYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLDDIVDVMFKGPEEKLNKTVY 77
A+VFPGQGSQY GM +F +E++ + E S ++ DI ++M G EE L T
Sbjct: 3 AFVFPGQGSQYSGMAKDF--SVYESSKEIF--ERSKKVLGFDITEIM-NGDEETLKLTEN 57
Query: 78 TQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYYRGKYM 137
QP+++ S + LE G PD VAGHSLGEYTALAVAG D + G L RG+YM
Sbjct: 58 AQPSIYITSYIAFLELEKRGI-LPDVVAGHSLGEYTALAVAGVYDFETGLYLVRKRGEYM 116
Query: 138 QEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEKPAVEKAAQ 197
+A+ GKG M A++ L E +EE + V + ANYNS Q VISG K +VEKA +
Sbjct: 117 SKALEPGKGTMAAVIGLNIETIEEVVNSIEGVYI---ANYNSHDQVVISGLKESVEKAME 173
Query: 198 IAKEMGG-RAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAKAHTMAH 256
I KE G R + L VS P H ++ A + + ++ + + + P+V N TAK
Sbjct: 174 ILKEKGARRVVELMVSSPFHTPFLEYAREKMKEEVEKVDFKKPRWPIVMNSTAKPTENPE 233
Query: 257 EIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTLPNVRVF 310
EI+ N+ QI PV W QSV M + GV FVE+GPK VL L ++ N + F
Sbjct: 234 EIKRNIIEQITGPVLWKQSVDTMKKMGVTEFVEVGPKTVLKNLCRRMGANAKHF 287
gb|AAF08794.1|AF184956_1 (AF184956) FenF [Bacillus subtilis]
Length = 400
Score = 180 bits (451), Expect = 2e-44
Identities = 106/306 (34%), Positives = 169/306 (54%), Gaps = 6/306 (1%)
Query: 14 MGKLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLDDIVDVMFKGPEEKLN 73
M LA++FPGQGSQ+VGMG F+ F + ++ M D+ + F G +L
Sbjct: 1 MNNLAFLFPGQGSQFVGMGKSFWNDFVLAKRLFEEASDAISM---DVKKLCFDGDMTELT 57
Query: 74 KTVYTQPALFAISLGIYKA-LESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYY 132
+T+ QPA+ +S+ Y+ ++ +G KP F+AGHSLGEY+AL AG + Q +L
Sbjct: 58 RTMNAQPAILTVSVIAYQVYMQEIGI-KPHFLAGHSLGEYSALVCAGVLSFQEAVKLIRQ 116
Query: 133 RGKYMQEAVPEGKGAMVAILKLPPEKVEEAC-ERAKDVGVVEPANYNSSTQTVISGEKPA 191
RG MQ A PE G M AI ++ + +++ C E + + V A NS Q VISG + A
Sbjct: 117 RGILMQNADPEQLGTMAAITQVYIQPLQDLCTEISTEDFPVGVACMNSDQQHVISGHRQA 176
Query: 192 VEKAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAKA 251
VE + A+ MG L VS P H S+M+ A++ F+ L Q ++ + P++ N TA
Sbjct: 177 VEFVIKKAERMGANHTYLNVSAPFHSSMMRSASEQFQTALNQYSFRDAEWPIISNVTAIP 236
Query: 252 HTMAHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTLPNVRVFN 311
+ H +R +L + PV+W +S+ ++ GV +E+GPKNVL L+++ ++ +
Sbjct: 237 YNNGHSVREHLQTHMTMPVRWAESMHYLLLHGVTEVIEMGPKNVLVGLLKKITNHIAAYP 296
Query: 312 VEKPED 317
+ + D
Sbjct: 297 LGQTSD 302
gi|840626 (L42526) transacylase [Bacillus subtilis]
Length = 400
Score = 178 bits (447), Expect = 5e-44
Identities = 100/306 (32%), Positives = 168/306 (54%), Gaps = 6/306 (1%)
Query: 14 MGKLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLDDIVDVMFKGPEEKLN 73
M LA++FPGQGSQ+VGMG F+ F + ++ DI + F G +L
Sbjct: 1 MNNLAFLFPGQGSQFVGMGKPFWNDFVLAKRLFEEASDAISF---DIKKLCFNGDMNELT 57
Query: 74 KTVYTQPALFAISLGIYKA-LESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYY 132
KT+ QPA+ +S+ ++ ++ +G KP F+AGHSLGEY+AL G + L
Sbjct: 58 KTMNAQPAILTVSVIAFQVYMQEIGI-KPRFLAGHSLGEYSALVCTGALSFHDAVTLVRQ 116
Query: 133 RGKYMQEAVPEGKGAMVAILKLPPEKVEEACERAK-DVGVVEPANYNSSTQTVISGEKPA 191
RG MQ A P+ +G M A+ +L + ++E C + + + A NS Q V+SG + A
Sbjct: 117 RGILMQNADPQQQGTMAAVTQLSLQTLQEICSKVSTEECPADVACMNSDQQHVVSGHREA 176
Query: 192 VEKAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAKA 251
VE+ ++A+E G + L VS P H S+++ A++ F+ L Q ++ P++ N TA
Sbjct: 177 VERVIRMAEEKGAKYTYLNVSAPFHSSMIRSASEQFQTVLHQYSFRDAAWPIISNVTAHP 236
Query: 252 HTMAHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTLPNVRVFN 311
++ + I +L + PV+W +S+ ++ QGV +E+GP NVLS L+++ ++ +
Sbjct: 237 YSSGNSINEHLKQHMTMPVRWAESIHYLLLQGVTEVIEMGPNNVLSGLLKKITNHIAPYP 296
Query: 312 VEKPED 317
+ + D
Sbjct: 297 LGQTSD 302
gb|AAD18446| (AE001614) Malonyl Acyl Carrier Transcyclase [Chlamydia pneumoniae]
Length = 308
Score = 173 bits (433), Expect = 2e-42
Identities = 107/286 (37%), Positives = 159/286 (55%), Gaps = 9/286 (3%)
Query: 16 KLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLDDIVDVMFKGPEEKLNKT 75
+ A++FPGQGSQYVGMG + Y ++ E ++ L SL I MF+GPE+ L +T
Sbjct: 4 RYAFLFPGQGSQYVGMGQDLYMEYPEVRELFDFANERLGFSLTSI---MFEGPEDLLMET 60
Query: 76 VYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYYRGK 135
V++Q A++ S+ + K L +P V+G SLGEYTAL + I V G L RG+
Sbjct: 61 VHSQLAIYLHSMAVVKVLSQRSSIQPSLVSGLSLGEYTALVASDRISVLDGLELVRKRGQ 120
Query: 136 YMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGV-VEPANYNSSTQTVISGEKPAVEK 194
M EA + GAM A+L LP E +E E +G + ANYN+ Q V++G V++
Sbjct: 121 LMNEACNQSPGAMAALLGLPSEVIE---ENITSLGQGIWIANYNAPKQLVVAGIAEKVDQ 177
Query: 195 AAQIAKEMG-GRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAKAHT 253
A ++ +++G +A+ LKVS H LM+ A D + +++ +PLV + K+
Sbjct: 178 AIELFRDLGCKKAVRLKVSGAFHTPLMQVAQDGLAPDIYALCMKDSSLPLVSHVVGKSLV 237
Query: 254 MAHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKL 299
E+R L Q+ SP WYQS + E VD F+E+GP VL+ L
Sbjct: 238 NTEEMRECLARQMTSPTLWYQSCYHI-ESEVDEFLELGPGKVLAGL 282
gb|AAD40110.1|AF155831_4 (AF155831) unknown [Bacillus cereus]
Length = 405
Score = 162 bits (407), Expect = 3e-39
Identities = 97/312 (31%), Positives = 156/312 (49%), Gaps = 5/312 (1%)
Query: 17 LAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLDDI-VDVMFKGPEEKLNKT 75
+ ++FPG GS Y GMG Y+ F ++ +L++ + + ++ ++K EKL +
Sbjct: 3 IVFMFPGVGSHYSGMGKYLYENFPVAREIFEEASDTLKIDMASLCMEKIYKADLEKLQNS 62
Query: 76 VYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYYRGK 135
Q AL S+ ++ E KP+ + G+SLGEYTAL +G I +L R
Sbjct: 63 ---QTALVTTSMAAFRVFEQEIGNKPEAMIGYSLGEYTALCASGAIAFSDTLKLVQERST 119
Query: 136 YMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGV-VEPANYNSSTQTVISGEKPAVEK 194
+ G M + L PE VE C G V + Y++ +T ISG AV+
Sbjct: 120 ILSSYALTIDGTMAWVNNLAPEIVEGICSELLTKGQEVYISAYDTPNKTSISGTNSAVQL 179
Query: 195 AAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAKAHTM 254
A ++ E GG AIPLK+S P H +M+PAA+ ++ L ++ +P++ N+ + +
Sbjct: 180 ACEMVVEHGGIAIPLKLSGPFHSPMMQPAAEKYKSVLENIDMKQPLVPVIANHDSSMYKG 239
Query: 255 AHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTLPNVRVFNVEK 314
IR NLY Q+ PVKW + ++ QG +E+GPK VL L+Q P + N E+
Sbjct: 240 VENIRENLYLQLIKPVKWLDMIHYLMNQGSMKAIEMGPKEVLKYLLQAINPAISTCNYER 299
Query: 315 PEDAESVLKAIT 326
+D + + T
Sbjct: 300 EKDILNTKNSFT 311
gb|AAC67831.1| (AE001297) Malonyl CoA-Acyl Carrier Transacylase [Chlamydia
trachomatis]
Length = 308
Score = 159 bits (398), Expect = 3e-38
Identities = 105/287 (36%), Positives = 155/287 (53%), Gaps = 7/287 (2%)
Query: 14 MGKLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLDDIVDVMFKGPEEKLN 73
M ++ +FPGQGSQ+VGMG + Y+Q E A + + L SL I MF+GPEE L
Sbjct: 1 MDRVGLLFPGQGSQFVGMGRDLYQQSSEVARLFSQADEFLGFSLSSI---MFEGPEEVLL 57
Query: 74 KTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYYR 133
KT +Q A++ SL + + L + +P V+G SLGEYTAL + I ++ G R+ R
Sbjct: 58 KTSNSQLAIYLHSLAVLEVLSTHCPFEPILVSGLSLGEYTALTASKRISLEDGLRIVQKR 117
Query: 134 GKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEKPAVE 193
+ M A E GAM A+L L + V A E D + ANYN+ Q VI+G + VE
Sbjct: 118 AELMNAACEESSGAMAAVLGLTADVVLPALESLGD--GIWVANYNAPKQIVIAGIRNKVE 175
Query: 194 KAAQIAKEMGG-RAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAKAH 252
+A+ I +E+G + + LKV+ H LM+ A D L Q I++ + N +
Sbjct: 176 EASVILRELGAKKVVMLKVAGAFHTPLMQTAQDELAPYLYQLAIKDSNVAFASNVIGELV 235
Query: 253 TMAHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKL 299
+ IR+ + Q+ P WYQ+ + + VD F+E+GP NVL+ L
Sbjct: 236 YESEAIRSLMVRQMTFPTLWYQTCFQI-DPKVDLFLELGPGNVLTGL 281
gb|AAF00957.1|AF183408_5 (AF183408) McyG [Microcystis aeruginosa]
Length = 2631
Score = 156 bits (390), Expect = 3e-37
Identities = 98/297 (32%), Positives = 159/297 (52%), Gaps = 12/297 (4%)
Query: 12 KDMGKLAYVFPGQGSQYVGMGYEFYKQ---FHETADVVHAVEHSLRMSLDDIVDVMFKGP 68
K K+A++F GQGSQYVGM ++ Y+ F +T D ++ +++ +++V+F
Sbjct: 1207 KRPSKIAFLFTGQGSQYVGMAHQLYQTQPTFRKTLDA--GEKYHQKLTGKSLLNVVFADT 1264
Query: 69 EEKLNKTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGAR 128
++ LN+T YTQPALF I + + + S G +P + GHSLGEY+A AG D++ G +
Sbjct: 1265 DDSLNQTAYTQPALFLIEVALAQLWHSWGI-QPAAILGHSLGEYSAACFAGVFDLESGLK 1323
Query: 129 LTYYRGKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGV-VEPANYNSSTQTVISG 187
L +RG M + +P+ +G M AI L V E C+ G+ + A N+ TVISG
Sbjct: 1324 LVSHRGNLMGQ-LPQNQGEMAAIF-LDKNSVVEHCQSQ---GIKIAIAAINAEQHTVISG 1378
Query: 188 EKPAVEKAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNY 247
EK ++K G + LKV+ H L++P F+ L + +I LV N
Sbjct: 1379 EKNVIQKLCNHFTNAGVKVRQLKVAHAFHSPLVEPMVAEFKTILQEISFSQPQISLVSNL 1438
Query: 248 TAKAHTMAHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTL 304
T + + + + V+++Q +++ G DTF+EIGP+ +LS +IQ +L
Sbjct: 1439 TGEIADDSIMTPEYWLQHLLNTVQFHQGALFLQSLGCDTFIEIGPQPILSGIIQSSL 1495
emb|CAB45522.1| (AJ007046) [acyl-carrier protein] S-malonyltransferase [Brassica
napus]
Length = 349
Score = 155 bits (389), Expect = 3e-37
Identities = 102/305 (33%), Positives = 153/305 (49%), Gaps = 14/305 (4%)
Query: 18 AYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLDDIVDVMFKGPEEKLNKTVY 77
A++FPGQG+Q VGMG E ++ + H L D+VDV GP+EKL+ TV
Sbjct: 49 AFLFPGQGAQAVGMGKEALS-VAAAGELYNKANHILGY---DLVDVCVNGPKEKLDSTVI 104
Query: 78 TQPALFAISLGIYKALESMG-----FPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYY 132
+QPA++ SL + L D G SLGEYTALA AG + G +L
Sbjct: 105 SQPAIYVTSLAAVELLRVREGGEKIINSVDVTCGLSLGEYTALAFAGAFSFEDGLKLVKL 164
Query: 133 RGKYMQEAVPEGKGAMVAILKLPPEKVEEACERAK----DVGVVEPANYNSSTQTVISGE 188
RG+ MQ A K AMV+I+ L EKV++ C+ A + V+ ANY +SG
Sbjct: 165 RGEAMQAAADAAKSAMVSIIGLDSEKVQQLCDAANQEVDEADKVQIANYLCPGNYAVSGG 224
Query: 189 KPAVEKAAQIAKEMGGR-AIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNY 247
+E AK R + L V+ H S M+PA LA+ I++ +IP++ N
Sbjct: 225 LKGIEVVEAKAKSFKARMTVRLAVAGAFHTSFMEPAVSRLEAALAETEIRSPRIPVISNV 284
Query: 248 TAKAHTMAHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTLPNV 307
A+ H I+ L Q+ SPV+W +V + +G+ + E+GP V++ + ++ +
Sbjct: 285 DAQPHADPDTIKKILARQVTSPVQWETTVKTLLSKGLKSSYELGPGKVIAGIFKRVDKSA 344
Query: 308 RVFNV 312
V N+
Sbjct: 345 SVENI 349
gb|AAC16926.2| (AC002338) putative malonyl-CoA:Acyl carrier protein transacylase
[Arabidopsis thaliana]
Length = 367
Score = 149 bits (373), Expect = 3e-35
Identities = 99/299 (33%), Positives = 149/299 (49%), Gaps = 22/299 (7%)
Query: 18 AYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLD----DIVDVMFKGPEEKLN 73
A++FPGQG+Q VGMG E + V A + + D D++D+ GP+EKL+
Sbjct: 65 AFLFPGQGAQAVGMGKE--------SQSVGAAGELYKKANDILGYDLLDICVNGPKEKLD 116
Query: 74 KTVYTQPALFAISLGIYKALE-----SMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGAR 128
TV +QPA++ SL + L D G SLGEYTALA AG + G +
Sbjct: 117 STVISQPAIYVTSLAAVELLRVREGGEQIINSVDVTCGLSLGEYTALAFAGAFSFEDGLK 176
Query: 129 LTYYRGKYMQEAVPEGKGAMVAILKLPPEKVEEACERAK----DVGVVEPANYNSSTQTV 184
L RG+ MQ A K AMV+I+ L EKV++ C+ A + V+ ANY
Sbjct: 177 LVKLRGEAMQAAADAAKSAMVSIIGLDSEKVQQLCDAANQEVDEADKVQIANYLCPGNYA 236
Query: 185 ISGEKPAVEKAAQIAKEMGGR-AIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPL 243
+SG +E AK R + L V+ H S M+PA LA I++ +IP+
Sbjct: 237 VSGGLKGIEVVEAKAKSFKARMTVRLAVAGAFHTSFMEPAVSRLEAALAATEIRSPRIPV 296
Query: 244 VQNYTAKAHTMAHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQ 302
+ N A+ H I+ L Q+ SPV+W +V + +G+ + E+GP V++ + ++
Sbjct: 297 ISNVDAQPHADPDTIKKILARQVTSPVQWETTVKTLLSKGLKSSYELGPGKVIAGIFKR 355
gb|AAD07158.1| (AE000530) malonyl coenzyme A-acyl carrier protein transacylase
(fabD) [Helicobacter pylori 26695]
Length = 309
Score = 147 bits (368), Expect = 1e-34
Identities = 94/285 (32%), Positives = 151/285 (52%), Gaps = 11/285 (3%)
Query: 18 AYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLDDIVDVMFKGPEEKLNKTVY 77
A +FPGQGSQ VGMG FY+ ++ ++L++ D+ +F+ E L ++ Y
Sbjct: 4 ALLFPGQGSQCVGMGKSFYESHTLAKELFERASNALKV---DMKKTLFE-ENELLKESAY 59
Query: 78 TQPALFAISLGIYKALESM--GFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYYRGK 135
TQPA++ +S Y+ L G KP F GHSLGE +A++++G +D + +LT+ RGK
Sbjct: 60 TQPAIYLVSYIAYQLLNKQVNGGLKPVFALGHSLGEVSAVSLSGALDFEKALKLTHQRGK 119
Query: 136 YMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEKPAVEKA 195
MQEA +M+ +L + E + C+R K+V AN+N Q V++G K ++
Sbjct: 120 MMQEACANKDASMMVVLGVSEESLLSLCQRTKNVWC---ANFNGGMQVVLAGIKDDLKAL 176
Query: 196 AQIAKEMGG-RAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAKAHTM 254
KEMG R + L++SV SHC ++P F+ L ++ ++ N T +A+
Sbjct: 177 EPTLKEMGAKRVVFLEMSVASHCPFLEPMTFKFQELLEKSLKDKFHFEIISNATNEAYHN 236
Query: 255 AHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKL 299
+ L Q+ PV+ YQ + + VD F E+G +VL L
Sbjct: 237 KAKAVELLSLQLTQPVR-YQDCVKSNNDRVDVFFELGCGSVLKGL 280
gi|4154593 (AE001447) MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE
[Helicobacter pylori J99]
Length = 309
Score = 146 bits (366), Expect = 2e-34
Identities = 93/285 (32%), Positives = 152/285 (52%), Gaps = 11/285 (3%)
Query: 18 AYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLDDIVDVMFKGPEEKLNKTVY 77
A +FPGQGSQ +GMG FY+ ++ + L++ D+ +F+ E L ++ Y
Sbjct: 4 ALLFPGQGSQCIGMGKSFYESHTLAKELFERASNVLKV---DMKKTLFE-ENELLKESAY 59
Query: 78 TQPALFAISLGIYKAL--ESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYYRGK 135
TQPA++ +S Y+ L ++ G KP F GHSLGE +A++++G +D + +LT+ RGK
Sbjct: 60 TQPAIYLVSYIAYQLLNKQANGGLKPVFALGHSLGEVSAVSLSGALDFEKALKLTHQRGK 119
Query: 136 YMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEKPAVEKA 195
MQEA +M+ +L + E + C+R K+V AN+N Q V++G K ++
Sbjct: 120 MMQEACANKDASMMVVLGVSEESLLSLCQRTKNVWC---ANFNGGMQVVLAGVKDDLKAL 176
Query: 196 AQIAKEMGG-RAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAKAHTM 254
KEMG R + L++SV SHC ++P F+ L ++ ++ N T +A+
Sbjct: 177 EPTLKEMGAKRVVFLEMSVASHCPFLEPMIFKFQELLEKSLKDKFHFEIISNATNEAYHN 236
Query: 255 AHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKL 299
+ L Q+ PV+ YQ + + VD F E+G +VL L
Sbjct: 237 KSKAVELLSLQLTQPVR-YQDCVKSNNDRVDVFFELGCGSVLKGL 280
emb|CAB13582| (Z99112) pksC [Bacillus subtilis] >gi|2634093|emb|CAB13593|
(Z99113) pksC [Bacillus subtilis]
Length = 288
Score = 146 bits (366), Expect = 2e-34
Identities = 104/288 (36%), Positives = 145/288 (50%), Gaps = 13/288 (4%)
Query: 17 LAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLDDIVDVMFKGPEEKLNKTV 76
+ YVFPGQGSQ GMG + +F E D + L S+ + + P LNKT
Sbjct: 2 ITYVFPGQGSQKQGMGSGLFDEFKELTDQADEI---LGYSIKRLC---LENPYSNLNKTQ 55
Query: 77 YTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYYRGKY 136
+TQPAL+ ++ Y KPDFVAGHSLGEY AL A D + G +L RG+
Sbjct: 56 FTQPALYVVNALSYLKKIRDEEVKPDFVAGHSLGEYNALFAAEAFDFETGLQLVRKRGEL 115
Query: 137 MQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEKPAVEKAA 196
M G M A++ L E+V +A + + V+ AN N+ Q VISG+K +EKAA
Sbjct: 116 MSLI---SNGGMAAVMGLNEEQVAKAL-KEYHLHDVDIANVNAPYQIVISGKKDEIEKAA 171
Query: 197 QIAKEMG--GRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAKAHTM 254
+ + M +PL VS H M A + F L IP++ N AK +T
Sbjct: 172 SLFETMTEVTMVLPLNVSGAFHSRYMNKAKEEFEEFLHAFYFSPPSIPVISNVYAKPYTY 231
Query: 255 AHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQ 302
++ L QI VKW S+ ++ ++G F E+GP NVL+ LI +
Sbjct: 232 EF-MKQTLADQINHSVKWTDSISYLMKKGHMEFEEVGPGNVLTGLIHR 278
sp|P73242|FABD_SYNY3 MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE (MCT)
>gi|1652346|dbj|BAA17269| (D90904) malonyl coenzyme
A-acyl carrier protein transacylase [Synechocystis sp.]
Length = 293
Score = 143 bits (358), Expect = 1e-33
Identities = 100/306 (32%), Positives = 152/306 (48%), Gaps = 14/306 (4%)
Query: 16 KLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLDDIVDVMFKGPEEKLNKT 75
K A+VFPGQGSQ VGMG + TA + + + +V+ +G E L T
Sbjct: 2 KTAWVFPGQGSQAVGMGVDLLS----TAIAKEKYQQAEEILGWSVVEKC-QGDEASLALT 56
Query: 76 VYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYYRGK 135
TQP L+ I + L GF +PD+VAGHSLGEY+AL AG D G +L R +
Sbjct: 57 QNTQPCLYVIEAILADLLRDKGF-QPDYVAGHSLGEYSALYAAGVFDFATGLQLVKQRSE 115
Query: 136 YMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEKPAVEKA 195
M A G M A++K ++++A +V + AN NS Q VISG VE
Sbjct: 116 VMASA---SGGMMAALMKFDQTQLQQALTDNTEVVL---ANDNSPEQVVISGTVAGVE-- 167
Query: 196 AQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAKAHTMA 255
A +A RA+PLKVS H S M + +F L + +P++ N
Sbjct: 168 AILANVKARRAVPLKVSGAFHSSFMAQPSQSFAQTLTACHFNDATVPVLSNVDPSPTQNG 227
Query: 256 HEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTLPNVRVFNVEKP 315
++ L Q+ V+W ++++ + E G + E+GP VL+ L ++T P++ + N+ +
Sbjct: 228 DRLKEKLIQQMTGSVRWRETMVNLGEIGATDYWEVGPGKVLTGLCKRTCPDLNLKNIGQL 287
Query: 316 EDAESV 321
+D S+
Sbjct: 288 DDLNSL 293
gi|2558838 (AF016585) polyketide synthase modules 1 and 2 [Streptomyces
caelestis]
Length = 4340
Score = 143 bits (357), Expect = 2e-33
Identities = 109/317 (34%), Positives = 161/317 (50%), Gaps = 15/317 (4%)
Query: 15 GKLAYVFPGQGSQYVGMGYEFYKQF-HETADVVHAVEHSLRMSLDDIVDVMFKGPE-EKL 72
G+LA +F GQG+Q+ GMG E Y H A + E R ++ +VMF + + L
Sbjct: 533 GRLALLFTGQGAQHPGMGQELYTTDPHFAAALDEVCEELQRCGTQNLREVMFTPDQPDLL 592
Query: 73 NKTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYY 132
++T YTQPALFA+ +Y+ L + G + V GHS+GE TA +AG +D+ ARL
Sbjct: 593 DRTEYTQPALFALQTALYRTLTARG-TQAHLVLGHSVGEITAAHIAGVLDLPDAARLITA 651
Query: 133 RGKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEKPAV 192
R M + +P G GAM+++ + E ++ VE A N T V+SG + A+
Sbjct: 652 RAHVMGQ-LPHG-GAMLSV-----QAAEHDLDQLAHTHGVEIAAVNGPTHCVLSGPRTAL 704
Query: 193 EKAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAKAH 252
E+ AQ +E R LKVS H +LM P AFR L Q IPL+ N T +
Sbjct: 705 EETAQHLREQNVRHTWLKVSHAFHSALMDPMLGAFRDTLNTLNYQPPTIPLISNLTGQIA 764
Query: 253 TMAHEIRNNLY-HQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTLPN---VR 308
H + + V++ +V H QG T++EIGP L+ L+ TL N +
Sbjct: 765 DPNHLCTPDYWIDHARHTVRFADAVQTAHHQGTTTYLEIGPHPTLTTLLHHTLDNPTTIP 824
Query: 309 VFNVEKPEDAESVLKAI 325
+ E+PE E++ +AI
Sbjct: 825 TLHRERPE-PETLTQAI 840
Score = 132 bits (328), Expect = 5e-30
Identities = 101/307 (32%), Positives = 150/307 (47%), Gaps = 14/307 (4%)
Query: 16 KLAYVFPGQGSQYVGMGYEFYKQF-HETADVVHAVEHSLRMSLDDIVDVMFKGPE-EKLN 73
+L +F GQG+Q+ GMG E Y H A + E R ++ +VMF + + L+
Sbjct: 2987 RLTLLFTGQGAQHPGMGQELYTTDPHFAAALDEICEELQRCGTQNLREVMFTPDQPDLLD 3046
Query: 74 KTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYYR 133
+T YTQPALFA+ +Y+ L + G + V GHS+GE TA +AG +D+ ARL R
Sbjct: 3047 RTEYTQPALFALQTALYRTLTAHG-TQAHLVLGHSVGEITAAHIAGVLDLPDAARLITAR 3105
Query: 134 GKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEKPAVE 193
M + +G AM+++ + E ++ VE A N T V+SG + A+E
Sbjct: 3106 AHLMGQLPHDG--AMLSV-----QAAEHDLDQLAHTHGVEIAAVNGPTHCVLSGPRTALE 3158
Query: 194 KAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAKAHT 253
+ AQ +E R LKVS H +LM P AFR L Q IPL+ N T +
Sbjct: 3159 ETAQHLREQNVRHTWLKVSHAFHSALMDPMLGAFRDTLNTLNYQPPTIPLISNLTGQIAD 3218
Query: 254 MAHEIRNNLY-HQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTLPN---VRV 309
H + + V++ +V H+Q T++EIGP L+ L+ TL N +
Sbjct: 3219 PNHLCTPDYWIDHARHTVRFADAVQTAHDQRTTTYLEIGPHPTLTTLLHHTLDNPTTIPT 3278
Query: 310 FNVEKPE 316
+ E PE
Sbjct: 3279 LHREHPE 3285
Score = 131 bits (326), Expect = 8e-30
Identities = 102/307 (33%), Positives = 151/307 (48%), Gaps = 14/307 (4%)
Query: 16 KLAYVFPGQGSQYVGMGYEFYKQF-HETADVVHAVEHSLRMSLDDIVDVMFKGPE-EKLN 73
+L +F GQG+Q+ GMG E Y H A + E R ++ +VMF + + L+
Sbjct: 1527 RLTLLFTGQGAQHRGMGQELYATDPHFAAALDEVCEELQRCGTQNLREVMFTPDQPDLLD 1586
Query: 74 KTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYYR 133
+T YTQPALFA+ +Y+ L + G + V GHS+GE TA +AG +D+ ARL R
Sbjct: 1587 RTEYTQPALFALQTALYRTLTARG-TQAHLVLGHSVGEITAAHIAGVLDLPDAARLITAR 1645
Query: 134 GKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEKPAVE 193
M + +P G GAM+++ + E ++ VE A N T V+SG + A+E
Sbjct: 1646 AHLMGQ-LPHG-GAMLSV-----QAAEHDLDQLAHTHGVEIAAVNGPTHCVLSGPRTALE 1698
Query: 194 KAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAKAHT 253
+ AQ + G R LKVS H +LM P AFR L Q IPL+ N T +
Sbjct: 1699 ETAQQLHQQGIRHTWLKVSHAFHSALMDPMLGAFRDTLNTLNYQPPTIPLISNLTGQIAD 1758
Query: 254 MAHEIRNNLY-HQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTLPN---VRV 309
H + + V++ +V H+Q T++EIG L+ L+ TL N +
Sbjct: 1759 PNHLCTPDYWIDHARHTVRFADAVQTAHDQRTTTYLEIGAHPTLTTLLHHTLDNPTTIPT 1818
Query: 310 FNVEKPE 316
+ E PE
Sbjct: 1819 LHREHPE 1825
emb|CAB13584| (Z99112) pksE [Bacillus subtilis] >gi|2634095|emb|CAB13595|
(Z99113) pksE [Bacillus subtilis]
Length = 650
Score = 140 bits (349), Expect = 2e-32
Identities = 101/291 (34%), Positives = 144/291 (48%), Gaps = 19/291 (6%)
Query: 17 LAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLDDIVDVMFKGPEEKLNKTV 76
+ YVFPGQGSQ GMG ++Q+ D + L S++ + + +N T
Sbjct: 2 ITYVFPGQGSQQKGMGQGLFEQYQHLTDQADQI---LGYSIEKLCT---EKSYLDVNHTE 55
Query: 77 YTQPALFAIS-LGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYYRGK 135
YTQPAL+ ++ L K +E G KPDF AGHSLGEY AL AG D + G RL RG+
Sbjct: 56 YTQPALYVVNALSYLKRVEETG-RKPDFAAGHSLGEYNALMAAGAFDFETGLRLVKKRGE 114
Query: 136 YMQEAVPEGKGAMVAILKLPPEKVEEACE--RAKDVGVVEPANYNSSTQTVISGEKPAVE 193
M G M A++ L E+V E R D+ V AN N+ Q VISG K +E
Sbjct: 115 LMGRIT---GGGMAAVIGLSKEQVTAVLEEHRLYDIDV---ANENTPQQIVISGPKKEIE 168
Query: 194 KAAQIAKEMGGRAI--PLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAKA 251
KA + + + PL VS H M A F+ + + IP++ N A+
Sbjct: 169 KARAVFENTKDVKLFHPLNVSGAFHSRYMNEAKQVFKQYIDSFQFAPLAIPVISNVYAEP 228
Query: 252 HTMAHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQ 302
+ +++ L Q+ + VKW S+ ++ +G F EIGP VL+ LI +
Sbjct: 229 YHQ-DRLKDTLSEQMDNTVKWTDSIRFLMGRGEMEFAEIGPGTVLTGLIHR 278
emb|CAB41041.1| (AJ132222) polyketide synthase [Streptomyces natalensis]
Length = 6797
Score = 139 bits (346), Expect = 4e-32
Identities = 103/311 (33%), Positives = 156/311 (50%), Gaps = 19/311 (6%)
Query: 15 GKLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLD-DIVDVMFKGPEEKLN 73
G+ A++F GQGSQ +GMG+E Y ++ AD AV +L L+ + DV++ E LN
Sbjct: 3825 GRTAFLFSGQGSQRLGMGWELYARYPVFADAFDAVCAALDEHLERPLRDVVWGEDAELLN 3884
Query: 74 KTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYYR 133
+T Y Q LFAI + +Y+ ES G +PDFVAGHS+GE A V+G + L R
Sbjct: 3885 QTAYAQAGLFAIEVALYRLAESWGM-RPDFVAGHSIGEVAAAHVSGVFSLPDACALVAAR 3943
Query: 134 GKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEKPAVE 193
G+ MQ+ +P G GAM+AI E + E V A N + VISG + AV
Sbjct: 3944 GRLMQQ-LPSG-GAMMAIRATEDEVLPHLAEG------VSLAAVNGPSSVVISGAEDAVL 3995
Query: 194 KAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYT---AK 250
A G + L+VS H LM+P + FR + + IP+V N T A+
Sbjct: 3996 AIAAHFAGEGRKTTRLRVSHAFHSPLMEPMLEEFRAVVTRLSFGTPTIPVVSNLTGRLAE 4055
Query: 251 AHTMAHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTLPN---- 306
+AH + + V++ + + +GV F+E+GP VLS + +++ +
Sbjct: 4056 PEQLAH--ADYWVRHVREAVRFADGIQALRAEGVTRFLELGPDGVLSAMARESASDDAVL 4113
Query: 307 VRVFNVEKPED 317
V ++PE+
Sbjct: 4114 APVLRRDRPEE 4124
Score = 136 bits (340), Expect = 2e-31
Identities = 104/292 (35%), Positives = 149/292 (50%), Gaps = 13/292 (4%)
Query: 15 GKLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLD-DIVDVMFKGPEEKLN 73
GKLA++F GQGSQ +GMG E Y ++ A+ + AV +L LD + DV++ E LN
Sbjct: 5539 GKLAFLFSGQGSQRLGMGRELYGRYPAFAEALDAVCAALDAHLDRPLRDVIWGEDAELLN 5598
Query: 74 KTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYYR 133
+T Y Q LFAI + +++ LES G +PD + GHS+GE A VAG + + L R
Sbjct: 5599 RTGYAQTGLFAIEVALFRLLESWGV-RPDHLLGHSIGEIAAAHVAGVLSLPDACALVAAR 5657
Query: 134 GKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEKPAVE 193
G+ MQ+ +P G GAM+AI E + E V A N + V+SG + V
Sbjct: 5658 GRLMQQ-LPSG-GAMMAIRATEDEVLPHLAEG------VSLAAVNGPSSVVVSGAEDEVL 5709
Query: 194 KAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAKAHT 253
A +E G + L+VS H LM+P FR +IP+V N T + T
Sbjct: 5710 ALAAHFEEEGRKTTRLRVSHAFHSPLMEPMLADFRAVADGMTYAAPRIPVVSNVTGRPAT 5769
Query: 254 MAHEIRNNLY--HQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQT 303
A E+ Y + V++ V + EQGV TF+E+GP LS L ++
Sbjct: 5770 -AEELCCAEYWVGHVREAVRFADGVGALREQGVTTFLELGPDGSLSALAAES 5820
Score = 125 bits (312), Expect = 4e-28
Identities = 106/294 (36%), Positives = 146/294 (49%), Gaps = 14/294 (4%)
Query: 18 AYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLD-DIVDVMF--KGPEEK--L 72
A++F GQGSQ GMG E + A AV L LD + D++F +G E L
Sbjct: 564 AFLFAGQGSQRPGMGRELHAAHPVFATAFDAVCAELDPHLDRPLRDIVFAEEGSAEAALL 623
Query: 73 NKTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYY 132
++T YTQ ALFA+ +++ +ES G P FVAGHS+GE TA V+G + + ARL
Sbjct: 624 DQTAYTQAALFALETALFRLVESWGVA-PRFVAGHSIGELTAAHVSGVLTLHDAARLVAA 682
Query: 133 RGKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEKPAV 192
RG MQ A+P G GAMVA+ E E V + A N TVISG++ AV
Sbjct: 683 RGTLMQ-ALPAG-GAMVAVQATEDEIRERLAGHEDHVAL---AAANGPDSTVISGDEQAV 737
Query: 193 EKAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAKAH 252
+ A + G R L+VS H M + FR +IP+V T
Sbjct: 738 TEIAAHWEAQGRRTKRLRVSHAFHSPHMDDMLEDFRRVARGLTFHAPRIPVVSTVTGALA 797
Query: 253 TMAHEIRNNLY--HQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTL 304
T E+R+ Y Q+ V++ +V + +GV TFVEIG VL+ ++Q L
Sbjct: 798 T-EDELRSPDYWVRQVRETVRFCAAVRTLEAEGVTTFVEIGTGGVLTPMVQDCL 850
Score = 123 bits (306), Expect = 2e-27
Identities = 103/318 (32%), Positives = 155/318 (48%), Gaps = 16/318 (5%)
Query: 15 GKLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLD-DIVDVMFKGPEEKLN 73
G+ A +F GQGSQ +GMG E ++ A+ V +L LD + DV+ EE LN
Sbjct: 2099 GRDAVLFSGQGSQRIGMGRELSGRYPVFAEAFDTVCAALDEHLDRPLRDVVRGEDEELLN 2158
Query: 74 KTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYYR 133
+TVY Q LFAI + +++ +ES G +P +VAGHS+GE A VAG + L R
Sbjct: 2159 RTVYAQAGLFAIEVALFRLVESWGV-RPHYVAGHSVGEIAAAHVAGVFSLADACALVAAR 2217
Query: 134 GKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEKPAVE 193
G+ MQ A+P G GAM AI E + + V A N + V+SG + AV
Sbjct: 2218 GRLMQ-ALPAG-GAMAAIRATEDEVLPHLADS------VSIAAVNGPSSVVVSGAEHAVL 2269
Query: 194 KAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAKAHT 253
A + G + L+VS H LM P FR ++ +V N T + T
Sbjct: 2270 SIAAHFEGAGRKTTRLRVSHAFHSPLMDPMLADFRAVAEGLTYGEPELAVVSNVTGQLAT 2329
Query: 254 MAHEIRNNLY--HQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTLPNVRVFN 311
++R Y + + V++ + + +GV F+E+GP VLS L +++ P+ V
Sbjct: 2330 -PDQLRTPEYWVTHVRAAVRFADGIRALGAEGVTRFLELGPDGVLSALARESAPDDAVCT 2388
Query: 312 VEKPED---AESVLKAIT 326
+D A ++L A+T
Sbjct: 2389 PVLRKDRSEAATLLAALT 2406
emb|CAA17262| (AL021899) pks12 [Mycobacterium tuberculosis]
Length = 4151
Score = 138 bits (343), Expect = 8e-32
Identities = 106/310 (34%), Positives = 151/310 (48%), Gaps = 15/310 (4%)
Query: 15 GKLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSL-RMSLDDIVDVMFKGPEEKLN 73
GK +VFPGQGSQ++GMG + + A+ + V L R L + +VM+ E LN
Sbjct: 2579 GKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHLLRPLREVMWGHDENLLN 2638
Query: 74 KTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYYR 133
T + QPALFA+ + +++ L S G +PDFV GHS+GE +A VAG + ++ A L R
Sbjct: 2639 STEFAQPALFAVEVALFRLLGSWGV-RPDFVMGHSIGELSAAHVAGVLSLENAAVLVAAR 2697
Query: 134 GKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEKPAVE 193
G+ MQ A+P G GAMVA+ + E+V D+ V N VISG + AV
Sbjct: 2698 GRLMQ-ALPAG-GAMVAV-QAAEEEVRPLLSAEVDIAAV-----NGPASLVISGAQNAVA 2749
Query: 194 KAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAKAHT 253
A + G R L VS H LM P D F A I I ++ N T +
Sbjct: 2750 AVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVISNVTGQLAG 2809
Query: 254 MAHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTLPNVRVFNV- 312
I V++ SV + G F+E+GP L I+++LP+V V +
Sbjct: 2810 DDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLPDVAVTTMS 2869
Query: 313 ----EKPEDA 318
++PE A
Sbjct: 2870 ALRKDRPEPA 2879
Score = 88.2 bits (215), Expect = 9e-17
Identities = 83/298 (27%), Positives = 130/298 (42%), Gaps = 22/298 (7%)
Query: 15 GKLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLD-DIVDVMFKGP-EEKL 72
GK +VFPGQGSQ++GMG E A + A + +D +VDV+ P L
Sbjct: 556 GKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFAEFVDWSLVDVLRGAPGAPGL 615
Query: 73 NKTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYY 132
++ QP LFA+ + + + +S+ PD V GHS GE A VAG + ++ AR+
Sbjct: 616 DRVDVVQPVLFAVMVSLAELWKSVAV-HPDAVIGHSQGEIAAAYVAGALSLRDAARVVTL 674
Query: 133 RGKYMQEAVPEGKGAMVAILKLPPEKVEEAC--ERAKDV-----GVVEPANYNSSTQTVI 185
R K + A G G MV+I AC ++A+D+ V A N + V+
Sbjct: 675 RSKLL--AGLAGPGGMVSI----------ACGADQARDLLAPFGDRVSIAVVNGPSAVVV 722
Query: 186 SGEKPAVEKAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQ 245
SGE A+E+ + R ++V SH ++ L+ ++ +
Sbjct: 723 SGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRSTRTVFFS 782
Query: 246 NYTAKAHTMAHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQT 303
T A + Y + V + Q+V EQG TF+E P L +++T
Sbjct: 783 TVTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPALITGVEET 840
emb|CAB06605| (Z84725) pks6 [Mycobacterium tuberculosis]
Length = 1402
Score = 138 bits (343), Expect = 8e-32
Identities = 105/312 (33%), Positives = 155/312 (49%), Gaps = 11/312 (3%)
Query: 2 DATLIIGLLSKDMGKLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLD-DI 60
+A ++ G+ K GK A+VF GQGSQ++GMG E Y + A+ + AV L L +
Sbjct: 617 EAGVVCGV-GKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHLRYPL 675
Query: 61 VDVMFKGPEEKLNKTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGG 120
DV++ ++ LN T + QPALFA+ + +Y+ L S G +P V GHS+GE A VAG
Sbjct: 676 RDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGV-RPGLVLGHSVGELAAAHVAGA 734
Query: 121 IDVQLGARLTYYRGKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSS 180
+ + A L RG+ MQ A+P G GAM A+ + E A DV + A N
Sbjct: 735 LCLPDAAMLVAARGRLMQ-ALPAG-GAMFAV---QAREDEVAPMLGHDVSI---AAVNGP 786
Query: 181 TQTVISGEKPAVEKAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIK 240
VISG AV A + G R L VS H +LM+P F A+ +
Sbjct: 787 ASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPT 846
Query: 241 IPLVQNYTAKAHTMAHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLI 300
IP++ N T + + I + V++ SV H G F+E+GP L+ LI
Sbjct: 847 IPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLI 906
Query: 301 QQTLPNVRVFNV 312
+ +L + ++ +V
Sbjct: 907 EASLADAQIVSV 918
gi|2558839 (AF016585) polyketide synthase module 3 [Streptomyces caelestis]
Length = 1839
Score = 137 bits (342), Expect = 1e-31
Identities = 104/307 (33%), Positives = 152/307 (48%), Gaps = 14/307 (4%)
Query: 16 KLAYVFPGQGSQYVGMGYEFYKQF-HETADVVHAVEHSLRMSLDDIVDVMFKGPE-EKLN 73
+L +F GQG+Q+ GMG E Y H A + E R ++ +VMF + + L+
Sbjct: 560 RLTLLFTGQGAQHPGMGQELYTTDPHFAAALDEVCEELQRCGTQNLREVMFTPDQPDLLD 619
Query: 74 KTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYYR 133
+T YTQPALFA+ +Y+ L + G + V GHS+GE TA +AG +D+ ARL R
Sbjct: 620 RTEYTQPALFALQTALYRTLTARG-TQAHLVLGHSVGEITAAHIAGVLDLPDAARLITAR 678
Query: 134 GKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEKPAVE 193
M + +P G GAM+++ + E ++ VE A N T V+SG + A+E
Sbjct: 679 AHLMGQ-LPHG-GAMLSV-----QAAEHDLDQLAHTHGVEIAAVNGPTHCVLSGPRTALE 731
Query: 194 KAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAKAHT 253
+ AQ +E R LKVS H +LM P AFR L Q IPL+ N T +
Sbjct: 732 ETAQHLREQNVRHTWLKVSHAFHSALMDPMLGAFRDTLNTLNYQPPTIPLISNLTGQIAD 791
Query: 254 MAHEIRNNLY-HQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTLPN---VRV 309
H + + V++ +V H QG T++EIGP L+ L+ TL N +
Sbjct: 792 PNHLCTPDYWIDHARHTVRFADAVQTAHHQGTTTYLEIGPHPTLTTLLHHTLDNPTTIPT 851
Query: 310 FNVEKPE 316
+ E PE
Sbjct: 852 LHREHPE 858
emb|CAA11039| (AJ223012) rifamycin polyketide synthase, type 1 [Amycolatopsis
mediterranei] >gi|2832264 (AF040570) polyketide synthase
[Amycolatopsis mediterranei]
Length = 3413
Score = 134 bits (334), Expect = 1e-30
Identities = 104/299 (34%), Positives = 146/299 (48%), Gaps = 20/299 (6%)
Query: 15 GKLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLDD-----IVDVMF-KGP 68
GK+ YVFPGQGSQ +GMG E Y ++ A L + L + DV+ + P
Sbjct: 551 GKVVYVFPGQGSQRLGMGRELYDRYPVFATAFDEACEQLDVCLAGRAGHRVRDVVLGEVP 610
Query: 69 EEK--LNKTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLG 126
E LN+TV+TQ LFA+ +++ ES G +PD V GHS+GE TA AG +
Sbjct: 611 AETGLLNQTVFTQAGLFAVESALFRLAESWGV-RPDVVLGHSIGEITAAYAAGVFSLPDA 669
Query: 127 ARLTYYRGKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVIS 186
AR+ RG+ MQ P G AMVA+ E E + VE A N + V+S
Sbjct: 670 ARIVAARGRLMQALAPGG--AMVAVAASEAEVAELLGDG------VELAAVNGPSAVVLS 721
Query: 187 GEKPAVEKAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQN 246
G+ AV AA +E G + LKVS H + M P F +LA + +IP+V N
Sbjct: 722 GDADAVVAAAARMRERGHKTKQLKVSHAFHSARMAPMLAEFAAELAGVTWREPEIPVVSN 781
Query: 247 YTAKAHTMAHEIRNNLY--HQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQT 303
T + E+ Y + PV++ + V E G FVE+GP L+ L+++T
Sbjct: 782 VTGR-FAEPGELTEPGYWAEHVRRPVRFAEGVAAATESGGSLFVELGPGAALTALVEET 839
Score = 87.0 bits (212), Expect = 2e-16
Identities = 80/293 (27%), Positives = 133/293 (45%), Gaps = 18/293 (6%)
Query: 15 GKLAYVFPGQGSQYVGMGYEFYKQ----FHETADVVHAVEHSLRMSLDDIVDVMFKGPEE 70
GKL +VFPGQG+Q+VGMG E ++ A+ A+E + SL D++ +G +
Sbjct: 2225 GKLVWVFPGQGTQWVGMGRELLEESPVFAERIAECAAALEPWIGWSLFDVL----RG-DG 2279
Query: 71 KLNKTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLT 130
L++ QPA FA+ +G+ S G PD V GHS GE A V+G + ++ A++
Sbjct: 2280 DLDRVDVLQPACFAVMVGLAAVWSSAGV-VPDAVLGHSQGEIAAACVSGALSLEDAAKVV 2338
Query: 131 YYRGKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEKP 190
R + + A G+G M ++ + EA ++ VE A N VI+G+
Sbjct: 2339 ALRSQAI-AAKLSGRGGMASV------ALGEADVVSRLADGVEVAAVNGPASVVIAGDAQ 2391
Query: 191 AVEKAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAK 250
A+++ + G RA + V SH ++ D LA + +P + T +
Sbjct: 2392 ALDETLEALSGAGIRARRVAVDYASHTRHVEDIEDTLAEALAGIDARAPLVPFLSTLTGE 2451
Query: 251 AHTMAHEIRNNL-YHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQ 302
+ Y + V++ +V + QG FVE+ VL + I +
Sbjct: 2452 WIRDEGVVDGGYWYRNLRGRVRFGPAVEALLAQGHGVFVELSAHPVLVQPITE 2504
emb|CAB09098| (Z95617) pks8 [Mycobacterium tuberculosis]
Length = 1602
Score = 133 bits (332), Expect = 2e-30
Identities = 104/321 (32%), Positives = 152/321 (46%), Gaps = 16/321 (4%)
Query: 11 SKDMGKLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLD-DIVDVMFKGPE 69
++ +GK +VFPGQG+Q+VGMG + Y + A AV L L + +V+++G E
Sbjct: 554 ARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHLRLPLRNVLWEGDE 613
Query: 70 EKLNKTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARL 129
L T + QPALFAI + + L+ G PDF+ GHS+GE A +AG + + A L
Sbjct: 614 ALLTSTEFAQPALFAIEVALATLLQHWGI-SPDFLIGHSVGEIAAAHLAGVLSLTDAAGL 672
Query: 130 TYYRGKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEK 189
RG+ M E +P G G MV + E + + A V N+ V+SG +
Sbjct: 673 VAARGRLMAE-LPAG-GVMVVVAASEEEVLPVLVDGANLAAV------NAPHSVVVSGCE 724
Query: 190 PAVEKAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTA 249
AV A G R L VS H LM+P F A + +IPLV N T
Sbjct: 725 AAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVSNVTG 784
Query: 250 KAHTMAHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTLP---- 305
+ + PV++ + V ++ G FVE+GP L+ L++Q+LP
Sbjct: 785 QMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLPLGEA 844
Query: 306 -NVRVFNVEKPEDAESVLKAI 325
+V + E PE SVL A+
Sbjct: 845 LSVAMMRREHPE-VSSVLGAV 864
gi|2529418 (U73935) unknown [Shewanella sp. SCRC-2738]
Length = 2756
Score = 132 bits (330), Expect = 3e-30
Identities = 104/310 (33%), Positives = 142/310 (45%), Gaps = 19/310 (6%)
Query: 15 GKLAYVFPGQGSQYVGMG------YEFYKQFHETADVVHAVEHSLRMSLDDIVDVMF--- 65
GK+A +F GQGSQY+ MG Y +Q TAD V A +S +F
Sbjct: 600 GKVAALFAGQGSQYLNMGRDLTCYYPEMRQQFVTADKVFAANDKTPLSQTLYPKPVFNKD 659
Query: 66 --KGPEEKLNKTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDV 123
K E L T Q A+ AIS+G Y + GF D VAGHS GE +AL AG I
Sbjct: 660 ELKAQEAILTNTANAQSAIGAISMGQYDLFTAAGF-NADMVAGHSFGELSALCAAGVISA 718
Query: 124 QLGARLTYYRGKYM------QEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANY 177
+L + RG+ M ++ V GAM AI+ +E V+ ANY
Sbjct: 719 DDYYKLAFARGEAMATKAPAKDGVEADAGAMFAIITKSAADLETVEATIAKFDGVKVANY 778
Query: 178 NSSTQTVISGEKPAVEKAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQ 237
N+ TQ+VI+G AA+ E+G +AI L VS H L+ A F + A
Sbjct: 779 NAPTQSVIAGPTATTADAAKALTELGYKAINLPVSGAFHTELVGHAQAPFAKAIDAAKFT 838
Query: 238 NIKIPLVQNYTAKAH-TMAHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVL 296
L N T + + A +I+ + + V++ + M+ G FVE GPKN+L
Sbjct: 839 KTSRALYSNATGGLYESTAAKIKASFKKHMLQSVRFTSQLEAMYNDGARVFVEFGPKNIL 898
Query: 297 SKLIQQTLPN 306
KL+Q TL N
Sbjct: 899 QKLVQGTLVN 908
gb|AAF19814.1|AF188287_6 (AF188287) MtaF [Stigmatella aurantiaca]
Length = 1360
Score = 129 bits (322), Expect = 2e-29
Identities = 93/293 (31%), Positives = 149/293 (50%), Gaps = 10/293 (3%)
Query: 16 KLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLDD-IVDVMFKGPEEKLNK 74
++ ++F GQGSQ+ GMG E Y+ + + + LR L++ +++V++ G L +
Sbjct: 563 EVVFLFTGQGSQHEGMGRELYETQPVYRESLKKSDELLRPVLNESLLEVLYGGKGHLLEQ 622
Query: 75 TVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYYRG 134
+ +QPALFA+ + + +S G KP V GHSLGEY A VAG + G ++ RG
Sbjct: 623 SGVSQPALFAVEYALAQLWKSWGV-KPAAVMGHSLGEYVAACVAGMCTQEEGLKVVAARG 681
Query: 135 KYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEKPAVEK 194
+ M E +PE G MVA+L + E A+ V V A N +TV+SG VE+
Sbjct: 682 RLM-EQLPEA-GEMVAVLAAEAKVQEAVAPYAQSVSV---AAVNGPEETVVSGRAAQVEQ 736
Query: 195 AAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAKAHTM 254
KE G LK + H LM+P + F + + + +I +V N + +
Sbjct: 737 VVSKLKEQGVDCRKLKTTHAFHSPLMEPMLEEFEKEAGKVKWKRPEIEVVSNVSGQL-AK 795
Query: 255 AHEIRNNLY--HQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTLP 305
E + Y I PVK+++ + ++E+G FVE+GPK L + ++ LP
Sbjct: 796 GEEGQKGEYWKKHIRQPVKYWEGLKGLYEKGYRVFVEVGPKPTLVNVGKRNLP 848
gb|AAF19812.1|AF188287_4 (AF188287) MtaD [Stigmatella aurantiaca]
Length = 3291
Score = 129 bits (322), Expect = 2e-29
Identities = 93/293 (31%), Positives = 149/293 (50%), Gaps = 10/293 (3%)
Query: 16 KLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLDD-IVDVMFKGPEEKLNK 74
++ ++F GQGSQ+ GMG E Y+ + + + LR L++ +++V++ G L +
Sbjct: 1984 EVVFLFTGQGSQHEGMGRELYETQPVYRESLKKSDELLRPVLNESLLEVLYGGKGHLLEQ 2043
Query: 75 TVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYYRG 134
+ +QPALFA+ + + +S G KP V GHSLGEY A VAG + G ++ RG
Sbjct: 2044 SGVSQPALFAVEYALAQLWKSWGV-KPAAVMGHSLGEYVAACVAGMCTQEEGLKVVAARG 2102
Query: 135 KYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEKPAVEK 194
+ M E +PE G MVA+L + E A+ V V A N +TV+SG VE+
Sbjct: 2103 RLM-EQLPEA-GEMVAVLAAEAKVQEAVAPYAQSVSV---AAVNGPEETVVSGRAAQVEQ 2157
Query: 195 AAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAKAHTM 254
KE G LK + H LM+P + F + + + +I +V N + +
Sbjct: 2158 VVSKLKEQGVDCRKLKTTHAFHSPLMEPMLEEFEKEAGKVKWKRPEIEVVSNVSGQL-AK 2216
Query: 255 AHEIRNNLY--HQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTLP 305
E + Y I PVK+++ + ++E+G FVE+GPK L + ++ LP
Sbjct: 2217 GEEGQKGEYWKKHIRQPVKYWEGLKGLYEKGYRVFVEVGPKPTLVNVGKRNLP 2269
dbj|BAA84479.1| (AB032367) type I polyketide synthase AVES 4 [Streptomyces
avermitilis]
Length = 4881
Score = 129 bits (322), Expect = 2e-29
Identities = 100/303 (33%), Positives = 140/303 (46%), Gaps = 22/303 (7%)
Query: 15 GKLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLD-----------DIVDV 63
GK A +F GQG+Q VGMG + Y AD + V L LD D+ DV
Sbjct: 3258 GKTAMLFAGQGTQRVGMGRQLYAAHPAYADALDQVLAELDGHLDQPLRPLIHASADLADV 3317
Query: 64 MFKGPEEKLNKTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDV 123
+ L++T Y QPALFA+ + +++ LE +G + DFVAGHS+GE A VAG + +
Sbjct: 3318 A--DAADVLDRTRYAQPALFAVQVALFRHLERLGV-RADFVAGHSIGELAAAHVAGVLPL 3374
Query: 124 QLGARLTYYRGKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQT 183
RL RG+ M++ P GAMVA+ E + R V V A N
Sbjct: 3375 AAACRLVAARGRLMEQLAP--GGAMVAVRASEAEARQALDGREARVSV---AAVNGPASV 3429
Query: 184 VISGEKPAVEKAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPL 243
V SG + V A E G R L+ H LM P + F+ A IP+
Sbjct: 3430 VFSGAEDEVGNMADWFAERGRRVKRLRTGHAFHSPLMDPMLEEFQQVAASLTYSEPAIPM 3489
Query: 244 VQNYTAKAHTMAHEIRNNLY--HQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQ 301
V T A E+ + Y Q+ V++ ++ +H GV TF+E+GP LS L +
Sbjct: 3490 VSTLTGDI-VAAGELSDPEYWVRQVRRTVRFGDAISRLHTDGVRTFMELGPDGTLSALAE 3548
Query: 302 QTL 304
+ L
Sbjct: 3549 ECL 3551
Score = 125 bits (311), Expect = 5e-28
Identities = 111/326 (34%), Positives = 151/326 (46%), Gaps = 23/326 (7%)
Query: 15 GKLAYVFPGQGSQYVGMG---YEFYKQFHETADVVHAVEHSLRMS-----LDDIVDVMFK 66
G+LA +F GQG+Q GMG YE Y F + D + A + R L D++
Sbjct: 573 GELAVLFAGQGTQRAGMGRELYEAYPVFAQAIDEICAEADTARTDPGAPGLRDVLFAPQD 632
Query: 67 GPEEKL-NKTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQL 125
PE +L T + QPALFA + +++ LE+ G PD+V GHS+GE A VAG + +
Sbjct: 633 SPEGRLIEDTGFAQPALFAFEVALFRLLETWGLT-PDYVLGHSVGELAAAHVAGMLCLAD 691
Query: 126 GARLTYYRGKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVI 185
L RG+ MQ +P G GAMVAI E + E A V A N V+
Sbjct: 692 AVALVVARGRLMQ-GLPSG-GAMVAIEASEDEILPLPDEYASRVA---HAAVNGPRSIVL 746
Query: 186 SGEKPAVEKAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQ 245
SG++ AV AQ G R L+ S H M FR Q +IP+V
Sbjct: 747 SGDEDAVLDLAQQWAARGRRTRRLRTSHAFHSPHMDAMLGDFRRAAEQVTFSAPRIPVVS 806
Query: 246 NYTAK---AHTMAHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQ 302
N T A TM + S V++ + W+ EQGV T +EIGP LS L Q
Sbjct: 807 NVTGAPLPAETMCTP--DYWVEHARSTVRFADGISWLQEQGVTTCLEIGPDGTLSALAQD 864
Query: 303 TL-PNVRVFNVEKPE--DAESVLKAI 325
+L R +P+ +A SV+ A+
Sbjct: 865 SLSAPARAIPALRPDQPEARSVMTAL 890
Score = 84.3 bits (205), Expect = 1e-15
Identities = 84/296 (28%), Positives = 130/296 (43%), Gaps = 16/296 (5%)
Query: 15 GKLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLD-DIVDVMFKGPEEK-L 72
GK+A +F GQG+ + GM E A + +L LD ++DV+ P+ L
Sbjct: 2134 GKIAMLFGGQGTHWEGMAQELLGSSPVFAQQMSDCAQALEPYLDWSLLDVLRGAPDAPPL 2193
Query: 73 NKTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYY 132
+ QP LFA+ + + S G PD VAGHS GE A VAG + + AR+T
Sbjct: 2194 QRVDVVQPVLFAVMVSLAALWRSYGV-HPDAVAGHSQGEIAAAYVAGALSLDDAARVTAL 2252
Query: 133 RGKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEKPAV 192
R + + A G+GAM ++ LP EK+E D V+ A N + V+SGE AV
Sbjct: 2253 RSQAL--AALAGQGAMASV-GLPVEKLEPRLATWGDRLVI--AAVNGARSAVVSGEPEAV 2307
Query: 193 EKAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQ--API--QNIKIPLVQNYT 248
+ + A L V SH P +A + +L + API + +P T
Sbjct: 2308 DALVEELSHEDVPARRLMVDWASH----SPQVEAIQGRLLELLAPIRARTGDVPFYSTVT 2363
Query: 249 AKAHTMAHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTL 304
+ + Y + V++ + + G F+E P ++ +Q+TL
Sbjct: 2364 GERIDGTELDADYWYRNLRQVVRFRDATQALVRAGHTVFIEACPHPAVAVGVQETL 2419
gi|2570220 (AF016890) heterocyst glycolipid synthase [Nostoc punctiforme]
Length = 1053
Score = 128 bits (318), Expect = 7e-29
Identities = 103/307 (33%), Positives = 150/307 (48%), Gaps = 25/307 (8%)
Query: 15 GKLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRM--SLDDIVDVMFKGP---- 68
GK+ +F GQGSQY+ MG E F +H SL + +L + +++F P
Sbjct: 633 GKVVSLFSGQGSQYLEMGRELVMNF-PLMRRLHGYMDSLLLKDNLQPLSEIVFPHPVFGE 691
Query: 69 EEK------LNKTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGID 122
EK L +T Y QPA+ +S G+Y L+ GF K DFVAGHS GE TAL AG +
Sbjct: 692 AEKNVQVAALQRTEYAQPAIGVLSAGMYSILQQAGF-KSDFVAGHSFGELTALWAAGVLS 750
Query: 123 VQLGARLTYYRGKYMQEAVPEGK----GAMVAILKLPPEKVEEACERAKDVGVVEPANYN 178
+ L RG+ M A PE G+M+A+ K KVE V + AN N
Sbjct: 751 TEDYLFLVKARGQAM--AAPEDPDHDAGSMLAV-KEDISKVEAVLRHFPQVAI---ANQN 804
Query: 179 SSTQTVISGEKPAVEKAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQN 238
S TQ V++G + + + E G A+ L VS H L+ A +F + Q+
Sbjct: 805 SPTQFVLAGPTAEIARIKEALHEKGYTAVLLPVSAAFHTPLIAFAQKSFAIATKSVKFQS 864
Query: 239 IKIPLVQNYTAKAHTM-AHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLS 297
KIP+ N T+K + A I+ L + + V + Q + ++ G FVE GP+ +LS
Sbjct: 865 PKIPVYSNVTSKQYPKEAQGIQKILETHLSNSVLFKQEIENIYAAGGTCFVEFGPRRILS 924
Query: 298 KLIQQTL 304
L+++ L
Sbjct: 925 NLVKEIL 931
dbj|BAA76543.1| (AB017641) polyketide synthase [Micromonospora griseorubida]
Length = 4290
Score = 127 bits (317), Expect = 9e-29
Identities = 96/296 (32%), Positives = 146/296 (48%), Gaps = 16/296 (5%)
Query: 17 LAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLDD-IVDVMFKGPEEK---- 71
LA++F GQGSQ +GM ++F A+ + + + LD ++ VMF P
Sbjct: 2987 LAFLFTGQGSQRLGMADGIRREFPPFAEALAEIAAEMDTRLDQPLLSVMFAEPGSATATL 3046
Query: 72 LNKTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTY 131
+++T Y QPALFA+ + +++ ES G +PD + GHS+GE A VAG +D++ RL
Sbjct: 3047 IDRTEYAQPALFAVEVALFRLFESWGV-RPDVLLGHSVGEIAAAHVAGVMDLEHACRLVA 3105
Query: 132 YRGKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVG-VVEPANYNSSTQTVISGEKP 190
RG+ MQ + GAM+AI +LP E+V E+ D+G V A N V+SG
Sbjct: 3106 ARGRLMQRMPAD--GAMIAI-RLPEERVR---EQLHDLGRHVSVAAVNGPESVVVSGAGH 3159
Query: 191 AVEKAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAK 250
V A G R L VS H + + FR A+ +P+V N T +
Sbjct: 3160 VVRSLADQLTAEGHRVRRLNVSHAFHSPHVDEVLEEFRKAAAEVRYGRPLVPVVSNVTGR 3219
Query: 251 AHTMAHEIRNNLY--HQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTL 304
T E+ + Y + PV+++ + + ++G T VE+GP VL L Q L
Sbjct: 3220 VAT-EDELGSAEYWVRHLREPVRFHDGIRTLLDRGATTLVELGPDGVLCGLAAQCL 3274
Score = 81.1 bits (197), Expect = 1e-14
Identities = 74/294 (25%), Positives = 125/294 (42%), Gaps = 11/294 (3%)
Query: 15 GKLAYVFPGQGSQYVGMGYEFYKQFHETA----DVVHAVEHSLRMSLDDIVDVMFKGPEE 70
G++A+VFPGQG+Q+ GM + A + AV + SL D++ + P
Sbjct: 486 GRVAWVFPGQGAQWTGMAAASLTESPVFAARLTECAAAVTPFVDWSLLDVLRAVPGSP-- 543
Query: 71 KLNKTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLT 130
+L++ QPA FA+ + + + S G P+ V GHS GE A VAG I ++ GAR+
Sbjct: 544 RLDRDDVVQPACFAVMVSLAELWRSWGVV-PEAVVGHSQGEIAAAVVAGAISLEDGARIV 602
Query: 131 YYRGKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEKP 190
R + + + G G MV++ LP + E R G + A N TV++G+
Sbjct: 603 ALRSQLLTREL-HGLGGMVSV-GLPVAETERLLTRWS--GRLHLAVVNGPNATVVAGDGD 658
Query: 191 AVEKAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAK 250
A+++ + R + V SH ++ D L Q +
Sbjct: 659 ALDELVTECERRQARVRRVAVEYASHSPHVERIRDELMTALRPVTPQPSAVAFYSTADVG 718
Query: 251 AHTMAHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTL 304
Y + PV++ ++ M G +FVE+ +L +++ L
Sbjct: 719 ITDGERLDAGYWYRNLRQPVRFADTLRQMSTDGYTSFVELSAHPMLVTALEEIL 772
Score = 60.9 bits (145), Expect = 1e-08
Identities = 81/326 (24%), Positives = 124/326 (37%), Gaps = 48/326 (14%)
Query: 5 LIIGLLSKDMGKLAYVFPGQGSQYVGMGYEFYKQ---FHETADVVHAVEHSLRMSLDDIV 61
+++G G + +VFPGQG+Q+VGM + F E D V V + +V
Sbjct: 1499 VVVGSGRVASGGVVFVFPGQGAQWVGMARGLLGESGVFSEAFDEVGGV-------VQGLV 1551
Query: 62 DVMFKGP------EEKLNKTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTAL 115
D +G L + QP F + + + + S G P +V GHS GE A
Sbjct: 1552 DWPVRGTACREVGRGDLGRVDVVQPLSFVVMVALARLSRSSGVVPPGWV-GHSQGEIAAA 1610
Query: 116 AVAGGIDVQLGARLTYYRGKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVV--- 172
V+G + V+ GAR+ R + + + G GAMV + VGVV
Sbjct: 1611 VVSGALSVEEGARVVVGRSRVIGARL-AGGGAMVWV--------------GASVGVVEGL 1655
Query: 173 --------EPANYNSSTQTVISGEKPAVEKAAQIAKEMGG---RAIPLKVSVPSHCSLMK 221
E A N Q V++G+ + +GG RA L V SHC L+
Sbjct: 1656 LGGLGGGLEVAVVNGPGQVVVAGD--GGWGGGVVGAGVGGWGVRARLLPVGYGSHCGLVD 1713
Query: 222 PAADAFRLKLAQAPIQNIKIPLVQNYTAKAHTMAHEIRNNLYHQIFSPVKWYQSVIWMHE 281
D L + + IP + + + V++ + V +
Sbjct: 1714 VVRDELLGVLGEVRGGSSVIPFYSSVDVGVVDGGVLDGGYWFRNLRLRVRFGEVVRRLVG 1773
Query: 282 QGVDTFVEIGPKNVLSKLIQQTLPNV 307
G +FVE+ VL I+ L V
Sbjct: 1774 DGFSSFVEVSAHPVLVGAIEDVLGEV 1799
emb|CAB52353.1| (AL109747) putative multi-domain beta keto-acyl synthase
[Streptomyces coelicolor A3(2)]
Length = 2082
Score = 125 bits (311), Expect = 5e-28
Identities = 100/309 (32%), Positives = 142/309 (45%), Gaps = 32/309 (10%)
Query: 15 GKLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLDDIVDVMFKGP----EE 70
G++ ++FPGQGSQYVGMG E TA V S+R + +F P EE
Sbjct: 607 GRIGFLFPGQGSQYVGMGAEL-AMLAPTAQAVWDRLGSIRFDGRPLHRAVFPPPAFTEEE 665
Query: 71 K------LNKTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQ 124
+ LN T + QPAL +L + + +G +PD VAGHS GE AL AG +D +
Sbjct: 666 RAARAALLNATEWAQPALAVHALALLAVVRELGL-RPDCVAGHSFGELVALHCAGALDAE 724
Query: 125 LGARLTYYRGKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVE--------PAN 176
L RG+ M+EA GAM+A+ A +R + V+ PAN
Sbjct: 725 SLVGLARRRGELMREAAAT-PGAMLAV----------AADRVRVAEVLAGGGFEDIWPAN 773
Query: 177 YNSSTQTVISGEKPAVEKAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPI 236
+NS QTV+SG AVE+A G + L S H L+ PA + L
Sbjct: 774 HNSPRQTVLSGSAAAVERARSAFSAAGIASRGLSASTAFHSPLVAPAVEPLAAHLRTVTF 833
Query: 237 QNIKIPLVQNYTAKAHTMAHE-IRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNV 295
+I + N A + + +R + + SPV + + M+ GV TFVE+G
Sbjct: 834 SEPRIEVYGNTDAAPYPSCPDAVRRRVAGHLASPVLFQDQIEAMYAAGVRTFVEVGAGAT 893
Query: 296 LSKLIQQTL 304
L+ L+ Q L
Sbjct: 894 LTGLVGQIL 902
emb|CAB09100| (Z95617) pks9 [Mycobacterium tuberculosis]
Length = 1017
Score = 125 bits (311), Expect = 5e-28
Identities = 104/331 (31%), Positives = 155/331 (46%), Gaps = 33/331 (9%)
Query: 3 ATLIIGLLSKDMGKLAYVFPGQGSQYVGMGYEFYKQFHETA----DVVHAVEHSLRMSLD 58
A +++G ++ +GK +VFPGQGSQ++GMG + Y ++ A +VV ++ LR+S
Sbjct: 490 AGVVVGR-ARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLS-- 546
Query: 59 DIVDVMFKGPEEKLNKTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVA 118
+ VM+ L T + QPALF + + + L+ G PD V GHS+GE A VA
Sbjct: 547 -VRQVMWGADAGLLESTEFAQPALFVVQVALAALLQDWGV-LPDLVMGHSVGEIAAAYVA 604
Query: 119 GGIDVQLGARLTYYRGKYMQEAVPEGKGAMVAIL----KLPPEKVEEACERAKDVGVVEP 174
G + + AR+ RG+ MQ A+P G G MVA+ ++ P E C A
Sbjct: 605 GALSLVDAARVVAARGRLMQ-ALPAG-GVMVAVAASEDEVAPLLTEGVCIAA-------- 654
Query: 175 ANYNSSTQTVISGEKPAVEKAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQA 234
N+ VISGE+ AV +G R L VS H LM P + F LA
Sbjct: 655 --VNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADV 712
Query: 235 PIQNIKIPLVQNYTAKAHTMAHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKN 294
++ +I LV N T + + + PV+++ V G FVE+GP
Sbjct: 713 CVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGA 772
Query: 295 VLSKLIQQTLPNVRVFNVEKPEDAESVLKAI 325
L +V + ++PE ESVL +
Sbjct: 773 GLE-------ASVALLARDRPE-VESVLAGV 795
gi|2624949 (AF007101) PKS module 2 [Streptomyces hygroscopicus]
Length = 1762
Score = 123 bits (306), Expect = 2e-27
Identities = 93/292 (31%), Positives = 139/292 (46%), Gaps = 16/292 (5%)
Query: 15 GKLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLDDIVDVMFKGPE-EKLN 73
G LA +F GQGSQ GMG + Y+ F A A++ ++ + +VMF + E L
Sbjct: 547 GPLAVMFTGQGSQRPGMGRQLYEHFPVFAQ---ALDEVFALATPGLREVMFDPDQAETLQ 603
Query: 74 KTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYYR 133
+T + Q ALFA +Y+ ES G +PD V GHS+GE TA V+G + + L R
Sbjct: 604 RTDHAQIALFAFETALYRLWESWGL-RPDMVCGHSVGEITAAHVSGTLTLPDAVHLVTTR 662
Query: 134 GKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEKPAVE 193
G MQ P GAM+A+ P ++ + D + A N TV+SG++ +
Sbjct: 663 GTLMQNLPP--GGAMLAV-ATDPHTLQPHLDNHHD--TISIAAINGPHATVLSGDRTTLH 717
Query: 194 KAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAKAHT 253
IA ++ + L VS H LM+P F L PL+ TA T
Sbjct: 718 ---HIATQLNTKTNWLNVSHAFHSPLMQPILQPFTTTLNTLTHHPPHTPLISMLTA---T 771
Query: 254 MAHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTLP 305
H + I +PV++ ++ +H G+ T++EIGP L+ L + TLP
Sbjct: 772 PTHPDTTHWTQHITAPVRYTDTLHHLHHHGITTYLEIGPDTTLTALARTTLP 823
gi|2555096 (AF015823) VenA [Streptomyces venezuelae]
Length = 467
Score = 122 bits (304), Expect = 3e-27
Identities = 96/297 (32%), Positives = 148/297 (49%), Gaps = 14/297 (4%)
Query: 15 GKLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLD-DIVDVMF--KGPEEK 71
G+ A + GQGSQ GMG E Y + A A+ L L + DV+F +G E+
Sbjct: 82 GRTAVLLTGQGSQRQGMGRELYDRSPVFAASFDAICAQLDGQLPRPLKDVLFAPEGSEDA 141
Query: 72 --LNKTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARL 129
+++TV+TQ ALFA+ +++ E+ G PD++ GHS+GE TA +AG +D+ L
Sbjct: 142 ALIDRTVFTQAALFAVETSLFRLFEAHGLV-PDYLIGHSIGEVTAAHLAGVLDLADACVL 200
Query: 130 TYYRGKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEK 189
+RG+ MQ A GAM A+ + ++V EA D V A N TV+SG++
Sbjct: 201 VAHRGRLMQSA--RAGGAMAAV-QASEDEVREALATFDD--AVAVAGVNGPNATVVSGDE 255
Query: 190 PAVEKAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTA 249
AVE+ +E G R L VS H M D F ++ ++ IP+V N T
Sbjct: 256 DAVERLVAAWREQGRRTKRLPVSHAFHSPHMDGIVDEFVTAVSGLTFRSPTIPVVSNVTG 315
Query: 250 KAHTMAHEIRNNLY--HQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTL 304
T+ ++ + Y I V + V ++ +GV ++E+GP VL L++ L
Sbjct: 316 TLATV-DQLTSPAYWARHIREAVPFADGVRYLEGEGVTEWLELGPDGVLVALVEDCL 371
emb|CAA87011| (Z46913) polyketide synthase [Streptomyces ambofaciens]
Length = 1198
Score = 122 bits (303), Expect = 4e-27
Identities = 102/318 (32%), Positives = 155/318 (48%), Gaps = 23/318 (7%)
Query: 11 SKDMGKLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLD-DIVDVMFKGPE 69
S + G+LA +F GQGSQ +GMG E Y F AD AV R+ L+ + +V+F
Sbjct: 168 SAESGRLALLFSGQGSQRLGMGRELYGAFPVFADAFDAV--CARVDLERPLREVVFGEDA 225
Query: 70 EKLNKTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARL 129
L +TVY Q LFA+ + +++ +ES G PD + GHS+GE A VAG + ++ L
Sbjct: 226 GLLERTVYAQAGLFALEVALFRLVESWGV-TPDVLVGHSIGELAAAHVAGVLSLEDACAL 284
Query: 130 TYYRGKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEK 189
RG+ M +A+P G GAM+A+ E EEA E V + A N T +SGE
Sbjct: 285 VSARGRLM-DALP-GGGAMLAV-----EVAEEALELPDGVDL---AAVNGPTSVTVSGEA 334
Query: 190 PAVEKAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTA 249
A+ + + + R L VS H LM+P F +IP+V
Sbjct: 335 EAIAELEERLRAQEVRVKRLAVSHAFHSHLMEPMLADFAAVARSLTYHTPRIPVVTTAPG 394
Query: 250 KAHTMAHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTLPNVRV 309
T + + Q+ PV++ ++ GV T +E+GP VLS L Q+ + ++
Sbjct: 395 DIATPEYWV-----GQVREPVRFADAL--GRFAGVRTALELGPAGVLSALAQEQVDSLVA 447
Query: 310 FNVEKP--EDAESVLKAI 325
+P +AE++L+ I
Sbjct: 448 VPALRPGHGEAETLLRVI 465
emb|CAB06103| (Z83858) pks1 [Mycobacterium tuberculosis]
Length = 1616
Score = 121 bits (301), Expect = 7e-27
Identities = 100/314 (31%), Positives = 146/314 (45%), Gaps = 15/314 (4%)
Query: 14 MGKLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLD-DIVDVMFKGPEEKL 72
+GK VFPGQG+Q +GMG E Y + A AV L L + DV++ + L
Sbjct: 80 VGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELDRHLRLPLRDVIWGADADLL 139
Query: 73 NKTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYY 132
+ T + QPALFA+ + + L G PDFV GHS+GE A AG + + A L
Sbjct: 140 DSTEFAQPALFAVEVASFAVLRDWGV-LPDFVMGHSVGELAAAHAAGVLTLADAAMLVVA 198
Query: 133 RGKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEKPAV 192
RG+ MQ A+P G GAMVA+ ++VE + VG+ A N+ VISG + A
Sbjct: 199 RGRLMQ-ALPAG-GAMVAV-AASEDEVEPLL--GEGVGI---AAINAPESVVISGAQAAA 250
Query: 193 EKAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAKAH 252
A G R L VS H LM+P + F A+ + ++ LV N T +
Sbjct: 251 NAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLGLVSNVTGELA 310
Query: 253 TMAHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTLPN-----V 307
+ PV++ S + G F+E GP + L+ I+Q+L V
Sbjct: 311 GPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQSLAPAEAMVV 370
Query: 308 RVFNVEKPEDAESV 321
+ ++PE A ++
Sbjct: 371 SMLGKDRPELASAL 384
pir||S73075 pks002c protein - Mycobacterium tuberculosis (fragment) >gi|560507
(U00024) polyketide synthase [Mycobacterium
tuberculosis]
Length = 950
Score = 121 bits (301), Expect = 7e-27
Identities = 100/314 (31%), Positives = 146/314 (45%), Gaps = 15/314 (4%)
Query: 14 MGKLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLD-DIVDVMFKGPEEKL 72
+GK VFPGQG+Q +GMG E Y + A AV L L + DV++ + L
Sbjct: 49 VGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELDRHLRLPLRDVIWGADADLL 108
Query: 73 NKTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYY 132
+ T + QPALFA+ + + L G PDFV GHS+GE A AG + + A L
Sbjct: 109 DSTEFAQPALFAVEVASFAVLRDWGV-LPDFVMGHSVGELAAAHAAGVLTLADAAMLVVA 167
Query: 133 RGKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEKPAV 192
RG+ MQ A+P G GAMVA+ ++VE + VG+ A N+ VISG + A
Sbjct: 168 RGRLMQ-ALPAG-GAMVAV-AASEDEVEPLL--GEGVGI---AAINAPESVVISGAQAAA 219
Query: 193 EKAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAKAH 252
A G R L VS H LM+P + F A+ + ++ LV N T +
Sbjct: 220 NAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLGLVSNVTGELA 279
Query: 253 TMAHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTLPN-----V 307
+ PV++ S + G F+E GP + L+ I+Q+L V
Sbjct: 280 GPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQSLAPAEAMVV 339
Query: 308 RVFNVEKPEDAESV 321
+ ++PE A ++
Sbjct: 340 SMLGKDRPELASAL 353
emb|CAA11035| (AJ223012) rifamycin polyketide synthase, type 1 [Amycolatopsis
mediterranei] >gi|2792314 (AF040570) polyketide synthase
[Amycolatopsis mediterranei]
Length = 4735
Score = 120 bits (299), Expect = 1e-26
Identities = 96/292 (32%), Positives = 144/292 (48%), Gaps = 14/292 (4%)
Query: 15 GKLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLDD--IVDVMFKGPEEKL 72
GKLA +F GQGSQ+ GMG E + F D A ++ L + + +V+F L
Sbjct: 2712 GKLAVLFTGQGSQWAGMGRELAETFPVFRDAFEAACEAVDTHLRERPLREVVF-DDSALL 2770
Query: 73 NKTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYY 132
++T+YTQ ALFA+ +++ ES G +P +AGHS+GE A V+G +D+ L
Sbjct: 2771 DQTMYTQGALFAVETALFRLFESWGV-RPGLLAGHSIGELAAAHVSGVLDLADAGELVAA 2829
Query: 133 RGKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEKPAV 192
RG+ MQ A+P G GAMVA+ + E+ D G V A N V+SG + AV
Sbjct: 2830 RGRLMQ-ALPAG-GAMVAV-----QATEDEVAPLLD-GTVCVAAVNGPDSVVLSGTEAAV 2881
Query: 193 EKAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAKAH 252
A G + L VS H LM+P D FR + + +P+V T +
Sbjct: 2882 LAVADELAGRGRKTRRLAVSHAFHSPLMEPMLDDFRAVAERLTYRAGSLPVVSTLTGE-- 2939
Query: 253 TMAHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTL 304
A + + Q+ + V++ +V + QG TF+E+GP L+ + TL
Sbjct: 2940 LAALDSPDYWVGQVRNAVRFSDAVTALGAQGASTFLELGPGGALAAMALGTL 2991
Score = 93.6 bits (229), Expect = 2e-18
Identities = 84/300 (28%), Positives = 139/300 (46%), Gaps = 16/300 (5%)
Query: 15 GKLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLD-DIVDVMFKGPEEKLN 73
GK+ +VFPGQG+Q+ GMG E + A+ + +L +D +VDV+ +G E L
Sbjct: 1141 GKVVWVFPGQGTQWAGMGRELLAESPVFAERIAECAAALAPWIDWSLVDVL-RG-EGDLG 1198
Query: 74 KTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYYR 133
+ QPA FA+ +G+ ES+G +PD V GHS GE A V+G + ++ A++ R
Sbjct: 1199 RVDVLQPACFAVMVGLAAVWESVGV-RPDAVVGHSQGEIAAACVSGALSLEDAAKVVALR 1257
Query: 134 GKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEKPAVE 193
+ + A G+G M ++ + V ++ V VE A N + VI+G+ A++
Sbjct: 1258 SQAI-AAELSGRGGMASVALGEDDVV------SRLVDGVEVAAVNGPSSVVIAGDAHALD 1310
Query: 194 KAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAKAHT 253
+I G R + V SH ++ D LA Q +P T++
Sbjct: 1311 ATLEILSGEGIRVRRVAVDYASHTRHVEDIRDTLAETLAGISAQAPAVPFYSTVTSEWVR 1370
Query: 254 MAHEIRNNL-YHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNV----LSKLIQQTLPNVR 308
A + Y + + V++ + + EQG FVE+ V LS+L + +R
Sbjct: 1371 DAGVLDGGYWYRNLRNQVRFGAAATALLEQGHTVFVEVSAHPVTVQPLSELTGDAIGTLR 1430
Score = 88.5 bits (216), Expect = 7e-17
Identities = 78/286 (27%), Positives = 129/286 (44%), Gaps = 13/286 (4%)
Query: 15 GKLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLD-DIVDVMFKGPEEKLN 73
GK+ +VFPGQGSQ++GMG + A + +L D ++DV+ +G + L+
Sbjct: 3691 GKVVWVFPGQGSQWMGMGRDLLDSSPVFAARIKECAAALEQWTDWSLLDVL-RGDADLLD 3749
Query: 74 KTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYYR 133
+ QPA FA+ +G+ S+G PD V GHS GE A V+G + + A++ R
Sbjct: 3750 RVDVVQPASFAMMVGLAAVWTSLGV-TPDAVLGHSQGEIAAACVSGALSLDDAAKVVALR 3808
Query: 134 GKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEKPAVE 193
+ + + G+G M ++ + V A VE A NS + VI+G+ A++
Sbjct: 3809 SQAIAGEL-AGRGGMASVALSEEDAVARLTPWANR---VEVAAVNSPSSVVIAGDAQALD 3864
Query: 194 KAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAKAHT 253
+A + G R + V SH ++ A+ LA + ++P + Y+ T
Sbjct: 3865 EALEALAGDGVRVRRVAVDYASHTRHVEAIAETLAKTLAGI---DARVPAIPFYSTVLGT 3921
Query: 254 MAHEI---RNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVL 296
+ Y + V++ SV + G FVEI VL
Sbjct: 3922 WIEQAVVDAGYWYRNLRQQVRFGPSVADLAGLGHTVFVEISAHPVL 3967
gi|2317864 (U78289) tylactone synthase module 7 [Streptomyces fradiae]
Length = 1841
Score = 116 bits (289), Expect = 2e-25
Identities = 96/307 (31%), Positives = 150/307 (48%), Gaps = 15/307 (4%)
Query: 5 LIIGLLSKDMGKLAYVFPGQGSQYVGMGYEFYKQ--FHETA--DVVHAVEHSLRMSLDDI 60
++ G+ +D G++A++F GQGSQ GM ++ + F +A +V ++ L L +
Sbjct: 565 VVRGVRDRD-GRMAFLFTGQGSQRAGMAHDLHAAHTFFASALDEVTDRLDPLLGRPLGAL 623
Query: 61 VDVMFKGPEEKL-NKTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAG 119
+D PE L ++T YTQPALFA+ + +++ LE G +PD + GHS+GE A VAG
Sbjct: 624 LDARPGSPEAALLDRTEYTQPALFAVEVALHRLLEHWGM-RPDLLLGHSVGELAAAHVAG 682
Query: 120 GIDVQLGARLTYYRGKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNS 179
+D+ L RG+ MQ P GAMV++ + ++V +D V A N
Sbjct: 683 VLDLDDACALVAARGRLMQRLPP--GGAMVSV-RAGEDEVRALLAGREDAVCV--AAVNG 737
Query: 180 STQTVISGEKPAVEKAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNI 239
VISG + AV +AA G R L+V+ H LM FR A +
Sbjct: 738 PRSVVISGAEEAVAEAAAQLAGRGRRTRRLRVAHAFHSPLMDGMLAGFREVAAGLRYREP 797
Query: 240 KIPLVQNYTAKAHTMAHEIRNNLY--HQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLS 297
++ +V T + E+ Y Q+ PV++ +V H G TF+E GP VL
Sbjct: 798 ELTVVSTVTGRP-ARPGELTGPDYWVAQVREPVRFADAVRTAHRLGARTFLETGPDGVLC 856
Query: 298 KLIQQTL 304
+ ++ L
Sbjct: 857 GMAEECL 863
emb|CAA60462| (X86780) polyketide synthase [Streptomyces hygroscopicus]
Length = 6260
Score = 114 bits (283), Expect = 9e-25
Identities = 97/314 (30%), Positives = 143/314 (44%), Gaps = 16/314 (5%)
Query: 16 KLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLD-DIVDVMF----KGPEE 70
++A++F GQG+Q +GMG E Y + A V LD + DV F
Sbjct: 5757 RVAFLFDGQGTQRLGMGKELYDSYPAFARAWDTVSAGFDKHLDHSLTDVCFGEGGSTTAG 5816
Query: 71 KLNKTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLT 130
++ T+Y Q +FA+ ++ LE G +PDFVAGHS+GE TA +G + ++ L
Sbjct: 5817 LVDDTLYAQAGIFAMEAALFGLLEDWGV-RPDFVAGHSIGEATAAYASGMLSLENVTTLI 5875
Query: 131 YYRGKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEKP 190
RG+ ++ P GAMVA L+ E+V E R ++ A NS V+SGE
Sbjct: 5876 VARGRALRTTPP---GAMVA-LRAGEEEVREFLSRTG--AALDLAAVNSPEAVVVSGEPE 5929
Query: 191 AVEKAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAK 250
V G A LKV H ++ D FR L + +P+V T +
Sbjct: 5930 PVADFEAAWTASGREARKLKVRHAFHSRHVEAVLDEFRTALESLKFRAPALPVVSTVTGR 5989
Query: 251 AHTMAHEIRNNLY--HQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTLPNVR 308
E+ Y Q+ PV++ +V + EQGV TFVE+GP L+ + L
Sbjct: 5990 LIDQ-DEMGTPEYWLRQVRRPVRFQDAVRELAEQGVGTFVEVGPSGALASAGVECLGGDA 6048
Query: 309 VFN-VEKPEDAESV 321
F+ V +P E V
Sbjct: 6049 SFHAVLRPRSPEDV 6062
Score = 96.7 bits (237), Expect = 2e-19
Identities = 90/286 (31%), Positives = 137/286 (47%), Gaps = 37/286 (12%)
Query: 16 KLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLDDIVDVMFKGPEEKLNKT 75
++ +VFPGQGSQ GMG E F A + V D++DV P+ +N+T
Sbjct: 542 RVVFVFPGQGSQRAGMGEELAAAFPVFARIHQQVW--------DLLDV----PDLDVNET 589
Query: 76 VYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYYRGK 135
Y QPALFA+ + ++ LES G +PD V GHS+GE A V+G ++ L R +
Sbjct: 590 GYAQPALFALQVALFGLLESWGV-RPDAVIGHSVGELAAAYVSGVWSLEDACTLVSARAR 648
Query: 136 YMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEKPAVEKA 195
MQ A+P G G MVA+ P +EA RA VE A N + V+SG++ AV +A
Sbjct: 649 LMQ-ALPAG-GVMVAV----PVSEDEA--RAVLGEGVEIAAVNGPSSVVLSGDEAAVLQA 700
Query: 196 AQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPL-VQNYTAKAHTM 254
A E G+ L S H + M+P + FR + ++ + V + A
Sbjct: 701 A----EGLGKWTRLATSHAFHSARMEPMLEEFRAVAEGLTYRTPQVSMAVGDQVTTAEYW 756
Query: 255 AHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLI 300
++R+ + + V Y+ + FVE+G L++L+
Sbjct: 757 VRQVRDTV--RFGEQVASYEDAV---------FVELGADRSLARLV 791
Score = 96.3 bits (236), Expect = 3e-19
Identities = 90/286 (31%), Positives = 137/286 (47%), Gaps = 37/286 (12%)
Query: 16 KLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLDDIVDVMFKGPEEKLNKT 75
+ +VFPGQGSQ GMG E F A + V D++DV P+ ++N+T
Sbjct: 2129 RAVFVFPGQGSQRAGMGEELAAAFPVFARIHQQVW--------DLLDV----PDLEVNET 2176
Query: 76 VYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYYRGK 135
Y QPALFA+ + ++ LES G +PD V GHS+GE A V+G ++ L R +
Sbjct: 2177 GYAQPALFAMQVALFGLLESWGV-RPDAVIGHSVGELAAAYVSGVWSLEDACTLVSARAR 2235
Query: 136 YMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEKPAVEKA 195
MQ A+P G G MVA+ P +EA RA VE A N + V+SG++ AV +A
Sbjct: 2236 LMQ-ALPAG-GVMVAV----PVSEDEA--RAVLGEGVEIAAVNGPSSVVLSGDEAAVLQA 2287
Query: 196 AQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPL-VQNYTAKAHTM 254
A E G+ L S H + M+P + FR + ++ + V + A
Sbjct: 2288 A----EGLGKWTRLATSHAFHSARMEPMLEEFRAVAEGLTYRTPQVSMAVGDQVTTAEYW 2343
Query: 255 AHEIRNNLYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLI 300
++R+ + + V Y+ + FVE+G L++L+
Sbjct: 2344 VRQVRDTV--RFGEQVASYEDAV---------FVELGADRSLARLV 2378
Score = 76.5 bits (185), Expect = 3e-13
Identities = 81/316 (25%), Positives = 137/316 (42%), Gaps = 25/316 (7%)
Query: 16 KLAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLDDIVDVMFKGPEEKLNKT 75
++ +VFPGQG Q++GMG A+ + +LR +D + + P +++
Sbjct: 3723 RIVFVFPGQGWQWLGMGSALRDSSVVFAERMAECAAALREFVDWDLFTVLDDPAV-VDRV 3781
Query: 76 VYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTYYRGK 135
QPA +A+ + + ++ G +PD V GHS GE A VAG + ++ AR+ R +
Sbjct: 3782 DVVQPASWAMMVSLAAVWQAAGV-RPDAVIGHSQGEIAAACVAGAVSLRDAARIVTLRSQ 3840
Query: 136 YMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEP---ANYNSSTQTVISGEKPAV 192
+ + G+GAM ++ LP A+DV +V+ A +N TVI+G AV
Sbjct: 3841 AIARGL-AGRGAMASV-ALP----------AQDVELVDGAWIAAHNGPASTVIAGTPEAV 3888
Query: 193 EKAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQ-APIQNIKIPLVQNYTAKA 251
+ + G R + V SH P + R +L + + PLV +
Sbjct: 3889 DHVLTAHEAQGVRVRRITVDYASH----TPHVELIRDELLDITSDSSSQTPLVPWLSTVD 3944
Query: 252 HTMAHEIRNN--LYHQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQTLPNVRV 309
T + Y + PV ++ +V + QG FVE+ VL + + + V
Sbjct: 3945 GTWVDSPLDGEYWYRNLREPVGFHPAVSQLQAQGDTVFVEVSASPVLLQAMDDDVVTVAT 4004
Query: 310 FNVEKPEDAESVLKAI 325
DA +L A+
Sbjct: 4005 LR-RDDGDATRMLTAL 4019
gi|2558842 (AF016585) polyketide synthase module 7 [Streptomyces caelestis]
Length = 1879
Score = 113 bits (281), Expect = 2e-24
Identities = 96/293 (32%), Positives = 136/293 (45%), Gaps = 14/293 (4%)
Query: 17 LAYVFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLD-DIVDVMFKGPEEK---- 71
+A++F GQG+Q G G E Y F A + V L+ ++ VMF P
Sbjct: 563 VAFLFSGQGAQRAGAGRELYASFPVFAQALDEVAGGFDAHLERPLLQVMFAEPGTADAAL 622
Query: 72 LNKTVYTQPALFAISLGIYKALESMGFPKPDFVAGHSLGEYTALAVAGGIDVQLGARLTY 131
L++T Y QPALFA+ +++ ES G PD + GHS+G A AG RL
Sbjct: 623 LDRTAYAQPALFAVETALFRLFESWGL-MPDVLLGHSIGGLAAAYAAGVFSSADAVRLVA 681
Query: 132 YRGKYMQEAVPEGKGAMVAILKLPPEKVEEACERAKDVGVVEPANYNSSTQTVISGEKPA 191
RG+ MQ +PEG GAMVA+ + ++V E A VV A +N V+SG++ A
Sbjct: 682 ARGRLMQR-LPEG-GAMVAV-RATEQEVAELEWIAGGRAVV--AAFNGPDSLVLSGDEQA 736
Query: 192 VEKAAQIAKEMGGRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLVQNYTAKA 251
V AA G R L VS H M FR + ++P+V T +
Sbjct: 737 VVSAAGELAARGRRTKRLSVSHAFHSPHMDAMLADFRAVAESVTYRTPRLPIVSEVTGRP 796
Query: 252 HTMAHEIRNNLY--HQIFSPVKWYQSVIWMHEQGVDTFVEIGPKNVLSKLIQQ 302
E+ + Y QI PV++ +V G TFVE+GP VLS + ++
Sbjct: 797 -AAPSELMDPGYWTRQIREPVRFAAAVRAARAAGAATFVELGPDAVLSGMARE 848
emb|CAA18261.1| (AL022237) bK1191B2.3 (PUTATIVE novel Acyl Transferase similar to
C. elegans C50D2.7) (isoform 1)) [Homo sapiens]
Length = 390
Score = 111 bits (274), Expect = 1e-23
Identities = 95/304 (31%), Positives = 142/304 (46%), Gaps = 32/304 (10%)
Query: 20 VFPGQGSQYVGMGYEFYKQFHETADVVHAVEHSLRMSLDDIVDVMFKGPEEKLNKTVYTQ 79
+FPGQGSQ VGMG + ++ A L D++++ GP+E L++TV+ Q
Sbjct: 66 LFPGQGSQVVGMGRGLLN-YPRVRELYAAARRVLGY---DLLELSLHGPQETLDRTVHCQ 121
Query: 80 PALFAISLGIYKALESMGFPKPDFV------AGHSLGEYTALAVAGGIDVQLGARLTYYR 133
PA+F SL A+E + +P + AG S+GE+ AL AG ++ G R
Sbjct: 122 PAIFVASLA---AVEKLHHLQPSVIENCVAAAGFSVGEFAALVFAGAMEFAEGLYAVKIR 178
Query: 134 GKYMQEAVPEGKGAMVAILKLPPEKVEEAC----ERAKDVGVVEP----ANYNSSTQTVI 185
+ MQEA M+++L P K AC E K +G+ P +NY VI
Sbjct: 179 AEAMQEASEAVPSGMLSVLGQPQSKFNFACLEAREHCKSLGIENPVCEVSNYLFPDCRVI 238
Query: 186 SGEKPAVEKAAQIAKEMG-GRAIPLKVSVPSHCSLMKPAADAFRLKLAQAPIQNIKIPLV 244
SG + A+ + + + R L VS H LM+PA + L +IK PLV
Sbjct: 239 SGHQEALRFLQKNSSKFHFRRTRMLPVSGAFHTRLMEPAVEPLTQALKAV---DIKKPLV 295
Query: 245 QNYT-AKAHTMAH--EIRNNLYHQIFSPVKWYQSVIWMHE----QGVDTFVEIGPKNVLS 297
Y+ AH H I L Q+ SPVKW Q++ ++E +G E+GP L
Sbjct: 296 SVYSNVHAHRYRHPGHIHKLLAQQLVSPVKWEQTMHAIYERKKGRGFPQTFEVGPGRQLG 355
Query: 298 KLIQ 301
+++
Sbjct: 356 AILK 359
gb|AAD54967.1|AF161721_1 (AF161721) malonyl CoA-acyl carrier protein transacylase
[Glomerella cingulata]
Length = 380
Score = 110 bits (272), Expect = 2e-23
Identities = 102/362 (28%), Positives = 162/362 (44%), Gaps = 55/362 (15%)
Query: 16 KLAYVFPGQGSQYVGMGYEFYKQFHETAD-VVHAVEHSLRMSLDDIVDVMFKGPEEKLNK 74
+ A FPGQG Q VGM + + F TA ++ ++H + L DI+ GP + L K
Sbjct: 10 RTALFFPGQGVQKVGMITPWLEAFPATAKPILEEIDHYMGFKLSDIIA---NGPGKLLTK 66
Query: 75 TVYTQPALFAISLGIYKALE-SMGFPKP---DFVAGHSLGEYTALAVAGGIDVQLGARLT 130
T QPA+ A S+ I + LE GF P D GHSLGE+ AL G ++ + L
Sbjct: 67 TPNAQPAIMATSILILRILEREFGFDIPQRVDVTLGHSLGEFAALVAGGYLEFEDSLYLV 126
Query: 131 YYRGKYMQEAVPE------GKGAMVAILKLPP------EKVEEAC---------ERAKDV 169
R + M EA G+ MVAI+ P E + + E ++DV
Sbjct: 127 RKRAEAMHEATRRAVDEYGGEYGMVAIVTEPEYLKGLIEAIHDFVGHSSAGSKGESSEDV 186
Query: 170 GVVEP---ANYNSSTQTVISGEKPAVEKAAQIAKEMGG---RAIPLKVSVPSHCSLMKPA 223
+E AN NS Q V+SG ++ A ++ G RA+ L P H +MKPA
Sbjct: 187 PPIEQVLIANINSKNQIVLSGNIERIKTLATHVRQFLGHDPRAVRLNSDSPFHSPIMKPA 246
Query: 224 ADAFRLKLAQAPI------QNI-----KIPLVQNYTAKAHTMAHEIRNNLYHQIFSPVKW 272
+ L + ++I K+P + N +A+ ++++ L Q V+W
Sbjct: 247 VSVVKSILNKKSRVKGREGEDIITFPGKLPCISNVSARPFESKEDVKDLLARQCLETVRW 306
Query: 273 YQSVIWM-HEQGVDTFVEIGPKNVLSKLI--------QQTLPNVRVFNVEKPEDAESVLK 323
+ S+ ++ E+ V +V IGP V L+ + ++ V+ + P + E VL+
Sbjct: 307 WDSIKYLDQEEKVRRWVGIGPGKVGRNLVGKEVGMRGKDSVKGGGVWAITDPSEIEEVLR 366
Query: 324 AI 325
+
Sbjct: 367 GL 368
Database: Non-redundant GenBank CDS
translations+PDB+SwissProt+SPupdate+PIR
Posted date: Jan 12, 2000 2:26 PM
Number of letters in database: 136,724,657
Number of sequences in database: 444,417
Lambda K H
0.317 0.134 0.385
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 87088908
Number of Sequences: 444417
Number of extensions: 3653320
Number of successful extensions: 9808
Number of sequences better than 10.0: 216
Number of HSP's better than 10.0 without gapping: 159
Number of HSP's successfully gapped in prelim test: 57
Number of HSP's that attempted gapping in prelim test: 8871
Number of HSP's gapped (non-prelim): 366
length of query: 326
length of database: 136,724,657
effective HSP length: 57
effective length of query: 269
effective length of database: 111,392,888
effective search space: 29964686872
effective search space used: 29964686872
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 70 (31.7 bits)
