Score E
Sequences producing significant alignments: (bits) Value
sp|O67221|AK_AQUAE ASPARTOKINASE (ASPARTATE KINASE) >gi|298... 767 0.0
emb|CAB45482.1| (AL079348) putative aspartokinase [Streptom... 359 3e-98
sp|P53553|AK2_BACST ASPARTOKINASE 2 (ASPARTOKINASE II) (ASP... 350 1e-95
gb|AAD49567.1|AF134837_1 (AF134837) aspartokinase subunit A... 345 5e-94
sp|P41403|AK_MYCSM ASPARTOKINASE (ASPARTATE KINASE) [CONTAI... 345 5e-94
sp|O25827|AK_HELPY ASPARTOKINASE (ASPARTATE KINASE) >gi|231... 344 6e-94
gi|4155744 (AE001542) ASPARTOKINASE 2 ALPHA AND BETA SUBUNI... 343 1e-93
sp|P26512|AK_CORGL ASPARTOKINASE (ASPARTATE KINASE) [CONTAI... 341 5e-93
sp|P41398|AK_CORFL ASPARTOKINASE (ASPARTATE KINASE) [CONTAI... 340 9e-93
sp|P97151|AK_THETH ASPARTOKINASE (ASPARTATE KINASE) [CONTAI... 338 6e-92
sp|P77991|AK_THEFL ASPARTOKINASE (ASPARTATE KINASE) [CONTAI... 337 1e-91
emb|CAA99580.1| (Z75208) aspartokinase II alpha subunit [Ba... 335 3e-91
sp|P08495|AK2_BACSU ASPARTOKINASE 2 (ASPARTOKINASE II) (ASP... 335 4e-91
sp|Q59229|AK2_BACSP ASPARTOKINASE 2 (ASPARTOKINASE II) (ASP... 334 7e-91
sp|P97048|AK_MYCTU ASPARTOKINASE (ASPARTATE KINASE) [CONTAI... 332 4e-90
dbj|BAA18676| (D90916) aspartate kinase [Synechocystis sp.] 329 2e-89
gb|AAD35632.1|AE001729_12 (AE001729) aspartokinase II [Ther... 312 2e-84
gb|AAD36585.1|AE001799_17 (AE001799) aspartokinase II [Ther... 305 6e-82
gi|1899205 (U90239) aspartokinase [Mycobacterium tuberculosis] 273 2e-72
sp|Q57991|AK_METJA PROBABLE ASPARTOKINASE (ASPARTATE KINASE... 218 8e-56
sp|Q9ZCI7|AK_RICPR ASPARTOKINASE (ASPARTATE KINASE) >gi|386... 216 3e-55
pir||S12250 aspartate kinase (EC 2.7.2.4) alpha chain - Cor... 214 1e-54
gi|3128465 (AF061757) aspartokinase [Pseudomonas aeruginosa] 209 4e-53
sp|Q04795|AK1_BACSU ASPARTOKINASE 1 (ASPARTOKINASE I) (ASPA... 202 5e-51
pir||C46665 aspartate kinase (EC 2.7.2.4) I - Bacillus subt... 202 5e-51
gi|2649914 (AE001056) aspartate kinase (lysC) [Archaeoglobu... 166 3e-40
emb|CAB57346.1| (Y15939) aspartokinase [Dichelobacter nodosus] 150 3e-35
gi|2621892 (AE000858) aspartokinase II alpha subunit [Metha... 150 3e-35
gb|AAF10936.1|AE001982_10 (AE001982) aspartate kinase [Dein... 142 4e-33
gb|AAF03452.1|AC010797_28 (AC010797) putative aspartate kin... 136 4e-31
gi|537245 (U14003) aspartokinase I-homoserine dehydrogenase... 135 6e-31
sp|P00561|AK1H_ECOLI BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE ... 132 5e-30
emb|CAA23660| (V00361) thrA gene [EC 2.7.2.4 and EC 1.1.1.3... 132 5e-30
sp|P27725|AK1H_SERMA BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE ... 130 2e-29
dbj|BAA38477| (D10386) aspartokinase I-homoserine dehydroge... 130 2e-29
gi|2257743 (U62020) lysine-sensitive aspartate kinase [Arab... 130 2e-29
dbj|BAA38474| (D10385) aspartokinase I-homoserine dehydroge... 130 2e-29
pir||S15277 aspartate kinase (EC 2.7.2.4) beta chain - Cory... 129 3e-29
pir||I40835 aspartokinase beta chain - Cornyebacterium lact... 129 6e-29
dbj|BAA38480| (D10387) aspartokinase I-homoserine dehydroge... 129 6e-29
gb|AAD49568.1|AF134837_2 (AF134837) aspartokinase subunit B... 128 7e-29
sp|P44505|AKH_HAEIN BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE D... 123 2e-27
emb|CAA78985| (Z17372) aspartokinase [Mycobacterium smegmatis] 123 3e-27
gb|AAD41796.1| (AF135862) precursor monofunctional aspartok... 120 3e-26
dbj|BAA07147.1| (D37928) aspartokinase beta-2 [Thermus aqua... 120 3e-26
emb|CAA67376| (X98873) aspartate kinase [Arabidopsis thaliana] 116 3e-25
dbj|BAA80125.1| (AP000060) 473aa long hypothetical aspartat... 109 5e-23
emb|CAA18652.1| (AL022599) aspartate kinase [Schizosaccharo... 106 4e-22
ref|NP_010972.1|HOM3| Aspartate kinase (L-aspartate 4-P-tra... 105 8e-22
sp|P08660|AK3_ECOLI LYSINE-SENSITIVE ASPARTOKINASE III (ASP... 103 2e-21
pir||KIECD3 aspartate kinase (EC 2.7.2.4) III - Escherichia... 101 1e-20
emb|CAB49950.1| (AJ248286) aspartate kinase related (lysC) ... 99 5e-20
sp|P94417|AK3_BACSU PROBABLE ASPARTOKINASE (ASPARTATE KINAS... 98 1e-19
gb|AAC67958.1| (AE001309) Aspartokinase III [Chlamydia trac... 98 2e-19
pir||S46497 ak-hsdh bifunctional enzyme precursor - Arabido... 97 2e-19
gb|AAD21689.1| (AC004793) Identical to gb|X71364 gene for a... 95 9e-19
gi|142524 (J03294) aspartokinase II beta subunit [Bacillus ... 94 2e-18
emb|CAA19688.1| (AL024486) aspartate kinase-homoserine dehy... 90 2e-17
dbj|BAA29952| (AP000003) 359aa long hypothetical protein [P... 90 3e-17
sp|P49079|AKH1_MAIZE BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE ... 89 5e-17
sp|P49080|AKH2_MAIZE BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE ... 89 9e-17
sp|Q9Z6L0|AK_CHLPN ASPARTOKINASE (ASPARTATE KINASE) >gi|437... 87 3e-16
sp|P37142|AKH_DAUCA BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE D... 87 3e-16
dbj|BAA11417| (D78573) aspartate kinase-homoserine dehydrog... 85 1e-15
gb|AAC05983.1| (AF049708) aspartokinase-homoserine dehydrog... 82 9e-15
gb|AAC05981.1| (AF049706) aspartokinase-homoserine dehydrog... 82 9e-15
emb|CAB49951.1| (AJ248286) aspartate kinase (lysC) related ... 78 1e-13
dbj|BAA30185| (AP000004) 346aa long hypothetical aspartokin... 76 6e-13
sp|P47731|AK_MYCBO ASPARTOKINASE (ASPARTATE KINASE) [CONTAI... 76 6e-13
emb|CAA50500.2| (X71364) beta-aspartyl phosphate homoserine... 73 3e-12
gi|1710435 (U76360) aspartokinase III [Aeromonas hydrophila] 62 8e-09
pir||S49977 lysC protein - Corynebacterium glutamicum (frag... 62 1e-08
gi|1899204 (U90239) aspartokinase [Mycobacterium tuberculosis] 59 7e-08
pir||A47594 aspartate kinase (EC 2.7.2.4) alpha chain - Cor... 53 3e-06
emb|CAA23585| (V00305) aspartokinase II-homoserine dehydrog... 52 1e-05
sp|P00562|AK2H_ECOLI BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE ... 52 1e-05
gi|2394378 (AF017758) aspartate kinase [Campylobacter coli] 49 8e-05
gi|2209379 (AF006720) ProJ [Bacillus subtilis] >gi|2634241|... 49 8e-05
gi|146841 (J01651) aspartokinase II-homoserine dehydrogenas... 49 8e-05
gb|AAD36847.1|AE001816_4 (AE001816) acetylglutamate kinase ... 46 4e-04
pir||I40723 lysC protein - Corynebacterium glutamicum >gi|5... 45 0.002
gi|2648892 (AE000988) acetolactate synthase, small subunit,... 44 0.003
emb|CAB49661.1| (AJ248285) uridylate kinase (pyrH) [Pyrococ... 39 0.052
sp|O13810|PROB_SCHPO PROBABLE GLUTAMATE 5-KINASE (GAMMA-GLU... 39 0.052
gb|AAD36671.1|AE001804_15 (AE001804) uridylate kinase [Ther... 39 0.068
sp|P73071|PROB_SYNY3 GLUTAMATE 5-KINASE (GAMMA-GLUTAMYL KIN... 39 0.068
ref|NP_011898.1|YHR033W| Pro1p (Gamma-glutamyl kinase); Yhr... 39 0.068
sp|P37144|DHON_METGL HOMOSERINE DEHYDROGENASE (HDH) >gi|216... 38 0.12
dbj|BAA30514| (AP000006) 226aa long hypothetical protein [P... 38 0.15
gi|2621082 (AE000796) conserved protein [Methanobacterium t... 38 0.15
emb|CAA55388| (X78809) uridine 5'-monophosphate (UMP) kinas... 38 0.15
sp|P29464|PYRH_ECOLI URIDYLATE KINASE (UK) (URIDINE MONOPHO... 38 0.15
gb|AAF21804.1|AF093219_3 (AF093219) N-acetylglutamate kinas... 38 0.20
dbj|BAA32344.1| (AB010087) UMP kinase [Pseudomonas aeruginosa] 38 0.20
gb|AAF21129.1|L78665_3 (L78665) homoserine dehydrogenase [M... 37 0.26
pir||S43237 coenzyme B(12)-dependent 2-methyleneglutarate m... 37 0.26
pir||S43552 2-methyleneglutarate mutase (EC 5.4.99.4) - Clo... 37 0.26
sp|P96488|PROB_STRTR GLUTAMATE 5-KINASE (GAMMA-GLUTAMYL KIN... 37 0.34
sp|Q57525|YG32_HAEIN HYPOTHETICAL PROTEIN HI1632 >gi|107499... 37 0.34
emb|CAA62038| (X90401) proline dehydrogenase [Bradyrhizobiu... 34 1.7
sp|O67221|AK_AQUAE ASPARTOKINASE (ASPARTATE KINASE) >gi|2983613 (AE000726)
aspartokinase [Aquifex aeolicus]
Length = 415
Score = 767 bits (1960), Expect = 0.0
Identities = 394/415 (94%), Positives = 394/415 (94%)
Query: 1 MKILVQKFGGTSVGTLERIELCAKRVIKALEKGYKPVVVSSAMAGETDSLIELAKKVHPR 60
MKILVQKFGGTSVGTLERIELCAKRVIKALEKGYKPVVVSSAMAGETDSLIELAKKVHPR
Sbjct: 1 MKILVQKFGGTSVGTLERIELCAKRVIKALEKGYKPVVVSSAMAGETDSLIELAKKVHPR 60
Query: 61 PPEREMDTLLAVGEQKAIALFAMTLNKLGYPAVSLCGWQVPIITDNVHTKARIRKIGISR 120
PPEREMDTLLAVGEQKAIALFAMTLNKLGYPAVSLCGWQVPIITDNVHTKARIRKIGISR
Sbjct: 61 PPEREMDTLLAVGEQKAIALFAMTLNKLGYPAVSLCGWQVPIITDNVHTKARIRKIGISR 120
Query: 121 LLSLIEEGYIPVVAGFQGVTEDWEITTLGRGGSDTTXXXXXXXXXXDCEINTDVPGVFTA 180
LLSLIEEGYIPVVAGFQGVTEDWEITTLGRGGSDTT DCEINTDVPGVFTA
Sbjct: 121 LLSLIEEGYIPVVAGFQGVTEDWEITTLGRGGSDTTAVALAAALKADCEINTDVPGVFTA 180
Query: 181 DPRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEEGTWIV 240
DPRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEEGTWIV
Sbjct: 181 DPRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEEGTWIV 240
Query: 241 PEDEVMEKVAVRGITVDTKETRFTVVRVPDKPGIAAEIFKALGDAHIVVDMIVQNVSHEG 300
PEDEVMEKVAVRGITVDTKETRFTVVRVPDKPGIAAEIFKALGDAHIVVDMIVQNVSHEG
Sbjct: 241 PEDEVMEKVAVRGITVDTKETRFTVVRVPDKPGIAAEIFKALGDAHIVVDMIVQNVSHEG 300
Query: 301 YTDMSFTVNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAKISIVGIGMKSAYGVAGRMFD 360
YTDMSFTVNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAKISIVGIGMKSAYGVAGRMFD
Sbjct: 301 YTDMSFTVNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAKISIVGIGMKSAYGVAGRMFD 360
Query: 361 ILARNGINIKAISTSEIKISCLIDEKYAELAVRALHXXXXXXXXXXXTINGKNKE 415
ILARNGINIKAISTSEIKISCLIDEKYAELAVRALH TINGKNKE
Sbjct: 361 ILARNGINIKAISTSEIKISCLIDEKYAELAVRALHEEFIEEMEEFETINGKNKE 415
emb|CAB45482.1| (AL079348) putative aspartokinase [Streptomyces coelicolor]
Length = 425
Score = 359 bits (911), Expect = 3e-98
Identities = 198/405 (48%), Positives = 271/405 (66%), Gaps = 9/405 (2%)
Query: 1 MKILVQKFGGTSVGTLERIELCAKRVIKALEKGYKPVVVSSAMAGETDSLIELAKKVHPR 60
M ++VQK+GG+SV E I+ AKR+++A + G + V V SAM TD LI+LA++V P
Sbjct: 1 MGLVVQKYGGSSVADAEGIKRVAKRIVEAKKNGNQVVAVVSAMGDTTDELIDLAEQVSPI 60
Query: 61 PPEREMDTLLAVGEQKAIALFAMTLNKLGYPAVSLCGWQVPIITDNVHTKARIRKIGISR 120
P RE+D LL GE+ ++AL AM + LG+ A S G Q +ITD+VH KARI + R
Sbjct: 61 PAGRELDMLLTAGERISMALLAMAIKNLGHEAQSFTGSQAGVITDSVHNKARIIDVTPGR 120
Query: 121 LLSLIEEGYIPVVAGFQGVTED-WEITTLGRGGSDTTXXXXXXXXXXD-CEINTDVPGVF 178
+ + ++EG + +VAGFQGV++D +ITTLGRGGSDTT D CEI TDV GVF
Sbjct: 121 IRTSVDEGNVAIVAGFQGVSQDSKDITTLGRGGSDTTAVALAAALDADVCEIYTDVDGVF 180
Query: 179 TADPRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEEGTW 238
TADPR+VP AKKI IS+E+MLELA+ G+KV+ R VE+A +YN+ IHVRS+FS +GTW
Sbjct: 181 TADPRVVPKAKKIDWISFEDMLELAASGSKVLLHRCVEYARRYNIPIHVRSSFSGLQGTW 240
Query: 239 IVPE-----DEVMEKVAVRGITVDTKETRFTVVRVPDKPGIAAEIFKALGDAHIVVDMIV 293
+ E ++ +E+ + G+ DT E + TVV VPDKPG AA IF+A+ DA + +DM+V
Sbjct: 241 VSSEPIKQGEKHVEQALISGVAHDTSEAKVTVVGVPDKPGEAAAIFRAIADAQVNIDMVV 300
Query: 294 QNVS--HEGYTDMSFTVNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAKISIVGIGMKSA 351
QNVS G TD+SFT+ K++ KA + ++K IG + DD++ KIS+VG GMKS
Sbjct: 301 QNVSAASTGLTDISFTLPKSEGRKAIDALEKNRPGIGFDSLRYDDQIGKISLVGAGMKSN 360
Query: 352 YGVAGRMFDILARNGINIKAISTSEIKISCLIDEKYAELAVRALH 396
GV F L+ G+NI+ ISTSEI+IS + + AVRA+H
Sbjct: 361 PGVTADFFTALSDAGVNIELISTSEIRISVVTRKDDVNEAVRAVH 405
sp|P53553|AK2_BACST ASPARTOKINASE 2 (ASPARTOKINASE II) (ASPARTATE KINASE 2) [CONTAINS:
ASPARTOKINASE II ALPHA SUBUNIT; ASPARTOKINASE II BETA
SUBUNIT] >gi|2126845|pir||JC4640 aspartate kinase (EC
2.7.2.4) II - Bacillus stearothermophilus >gi|928811
(L46351) aspartate kinase [Bacillus stearothermophilus]
Length = 407
Score = 350 bits (889), Expect = 1e-95
Identities = 196/397 (49%), Positives = 258/397 (64%), Gaps = 5/397 (1%)
Query: 1 MKILVQKFGGTSVGTLERIELCAKRVIKALEKGYKPVVVSSAMAGETDSLIELAKKVHPR 60
M I+VQKFGGTSVG++ERI+ A RVI+ ++KG VVV SAM TD L+ LAK++
Sbjct: 1 MGIIVQKFGGTSVGSIERIQHVANRVIEEVQKGNDVVVVVSAMGKTTDELVNLAKQISNH 60
Query: 61 PPEREMDTLLAVGEQKAIALFAMTLNKLGYPAVSLCGWQVPIITDNVHTKARIRKIGISR 120
P +REMD LL+ GEQ +IAL AM+L++ GY AVSL GWQ I T+ +H ARI I +R
Sbjct: 61 PSKREMDMLLSTGEQVSIALLAMSLHEKGYKAVSLTGWQAGITTEEMHGNARIMNIDTTR 120
Query: 121 LLSLIEEGYIPVVAGFQGVTEDWEITTLGRGGSDTTXXXXXXXXXXD-CEINTDVPGVFT 179
+ ++EG I +VAGFQGVTE EITTLGRGGSDTT + C+I TDV GVFT
Sbjct: 121 IRRCLDEGAIVIVAGFQGVTETGEITTLGRGGSDTTAVALAAALKAEKCDIYTDVTGVFT 180
Query: 180 ADPRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEEGTWI 239
DPR V A+KIK+ISY+EMLELA+LGA V+ R+VEFA Y V + VRS+ E GT +
Sbjct: 181 TDPRYVKTARKIKEISYDEMLELANLGAGVLHPRAVEFAKNYEVPLEVRSSMENERGTMV 240
Query: 240 VPEDEVMEKVAVRGITVDTKETRFTVVRVPDKPGIAAEIFKALGDAHIVVDMIVQNVSHE 299
E + + + VRGI + + TR TVV + A IF AL + I VD+I+QN ++
Sbjct: 241 KEEVSMEQHLIVRGIAFEDQVTRVTVVGIEKYLQSVATIFTALANRGINVDIIIQNATNS 300
Query: 300 GYTDMSFTVNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAKISIVGIGMKSAYGVAGRMF 359
+SF++ D + +++ Q + +V + +AK+SIVG GM S GVA R+F
Sbjct: 301 ETASVSFSIRTEDLPETLQVL----QALEGADVHYESGLAKVSIVGSGMISNPGVAARVF 356
Query: 360 DILARNGINIKAISTSEIKISCLIDEKYAELAVRALH 396
++LA GI IK +S SEIKIS +IDEKY AV LH
Sbjct: 357 EVLADQGIEIKMVSISEIKISTVIDEKYMVSAVEELH 393
gb|AAD49567.1|AF134837_1 (AF134837) aspartokinase subunit A [Amycolatopsis mediterranei]
Length = 421
Score = 345 bits (875), Expect = 5e-94
Identities = 184/402 (45%), Positives = 269/402 (66%), Gaps = 6/402 (1%)
Query: 1 MKILVQKFGGTSVGTLERIELCAKRVIKALEKGYKPVVVSSAMAGETDSLIELAKKVHPR 60
M ++VQK+GG+S+ + +RI+ A+R++ + G VVV SAM TD L++LA++V+P
Sbjct: 1 MALVVQKYGGSSLESADRIKRVAERIVATKKAGNDVVVVCSAMGDTTDELLDLAQQVNPA 60
Query: 61 PPEREMDTLLAVGEQKAIALFAMTLNKLGYPAVSLCGWQVPIITDNVHTKARIRKIGISR 120
PPEREMD LL GE+ + +L AM + G A S G Q ++T +VH ARI + SR
Sbjct: 61 PPEREMDMLLTAGERISNSLVAMAIAAQGAEAWSFTGSQAGVVTTSVHGNARIIDVTPSR 120
Query: 121 LLSLIEEGYIPVVAGFQGVTEDW-EITTLGRGGSDTTXXXXXXXXXXD-CEINTDVPGVF 178
+ +++GYI +VAGFQGV +D +ITTLGRGGSDTT D CEI +DV GV+
Sbjct: 121 VTEALDQGYIALVAGFQGVAQDTKDITTLGRGGSDTTAVALAAALNADVCEIYSDVDGVY 180
Query: 179 TADPRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEEGTW 238
TADPR+VP+AKK+ ++YEEMLELA+ G+K++ +RSVE+A +Y V I VRS++S++ GT
Sbjct: 181 TADPRVVPDAKKLDTVTYEEMLELAASGSKILHLRSVEYARRYGVPIRVRSSYSDKPGTT 240
Query: 239 IVP--EDEVMEKVAVRGITVDTKETRFTVVRVPDKPGIAAEIFKALGDAHIVVDMIVQNV 296
+ E+ +E+ + G+ D E + TV VPD G AA IF+ + DA I +DM++QNV
Sbjct: 241 VTGSIEEIPVEQALITGVAHDRSEAKITVTGVPDHTGAAARIFRVIADAEIDIDMVLQNV 300
Query: 297 SH--EGYTDMSFTVNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAKISIVGIGMKSAYGV 354
S G TD++FT++K + KA + ++K+ +IG + V+ DD V K+S+VG GM+S GV
Sbjct: 301 SSTVSGRTDITFTLSKANGAKAVKELEKVQAEIGFESVLYDDHVGKVSVVGAGMRSHPGV 360
Query: 355 AGRMFDILARNGINIKAISTSEIKISCLIDEKYAELAVRALH 396
+ LA G+NI+ I+TSEI+IS LI + + AVRA+H
Sbjct: 361 TATFCEALAEAGVNIEIINTSEIRISVLIRDAQLDDAVRAIH 402
sp|P41403|AK_MYCSM ASPARTOKINASE (ASPARTATE KINASE) [CONTAINS: ASPARTOKINASE ALPHA
SUBUNIT (ASK-ALPHA); ASPARTOKINASE BETA SUBUNIT
(ASK-BETA)] >gi|421602|pir||S31801 aspartate kinase (EC
2.7.2.4) alpha chain - Mycobacterium smegmatis
>gi|581352|emb|CAA78984| (Z17372) aspartokinase
[Mycobacterium smegmatis]
Length = 421
Score = 345 bits (875), Expect = 5e-94
Identities = 186/402 (46%), Positives = 262/402 (64%), Gaps = 6/402 (1%)
Query: 1 MKILVQKFGGTSVGTLERIELCAKRVIKALEKGYKPVVVSSAMAGETDSLIELAKKVHPR 60
M ++VQK+GG+SV ERI A+R+++ + G VVV SAM TD L++LA++V P
Sbjct: 1 MALVVQKYGGSSVADAERIRRVAERIVETKKAGNDVVVVVSAMGDTTDDLLDLARQVSPA 60
Query: 61 PPEREMDTLLAVGEQKAIALFAMTLNKLGYPAVSLCGWQVPIITDNVHTKARIRKIGISR 120
PP REMD LL GE+ + AL AM + LG A S G Q +IT H A+I + R
Sbjct: 61 PPPREMDMLLTAGERISNALVAMAIESLGAQARSFTGSQAGVITTGTHGNAKIIDVTPGR 120
Query: 121 LLSLIEEGYIPVVAGFQGVTED-WEITTLGRGGSDTTXXXXXXXXXXD-CEINTDVPGVF 178
L ++EG I +VAGFQGV++D ++TTLGRGGSDTT D CEI TDV G+F
Sbjct: 121 LRDALDEGQIVLVAGFQGVSQDSKDVTTLGRGGSDTTAVAVAAALDADVCEIYTDVDGIF 180
Query: 179 TADPRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEEGTW 238
TADPRIVPNA+ + +S+EEMLE+A+ GAKV+ +R VE+A +YNV IHVRS++S++ GT
Sbjct: 181 TADPRIVPNARHLDTVSFEEMLEMAACGAKVLMLRCVEYARRYNVPIHVRSSYSDKPGTI 240
Query: 239 IVP--EDEVMEKVAVRGITVDTKETRFTVVRVPDKPGIAAEIFKALGDAHIVVDMIVQNV 296
+ ED ME + G+ D E + TVV +PD PG AA++F+A+ +A + +DM++QN+
Sbjct: 241 VKGSIEDIPMEDAILTGVAHDRSEAKVTVVGLPDVPGYAAKVFRAVAEADVNIDMVLQNI 300
Query: 297 S--HEGYTDMSFTVNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAKISIVGIGMKSAYGV 354
S +G TD++FT + + +A E + + +IG +V+ DD + K+S++G GM+S GV
Sbjct: 301 SKIEDGKTDITFTCARDNGPRAVEKLSALKSEIGFSQVLYDDHIGKVSLIGAGMRSHPGV 360
Query: 355 AGRMFDILARNGINIKAISTSEIKISCLIDEKYAELAVRALH 396
+ LA GINI ISTSEI+IS LI + + AV ALH
Sbjct: 361 TATFCEALAEAGINIDLISTSEIRISVLIKDTELDKAVSALH 402
sp|O25827|AK_HELPY ASPARTOKINASE (ASPARTATE KINASE) >gi|2314392|gb|AAD08274.1|
(AE000628) aspartokinase (lysC) [Helicobacter pylori
26695]
Length = 405
Score = 344 bits (874), Expect = 6e-94
Identities = 192/399 (48%), Positives = 262/399 (65%), Gaps = 7/399 (1%)
Query: 3 ILVQKFGGTSVGTLERIELCAKRVIKALEKGYKPVVVSSAMAGETDSLIELAKKVHPRPP 62
++VQK+GGTS+G++ERI A+RV++++ G++ VVV SAM+GETD L+E K P
Sbjct: 2 LIVQKYGGTSMGSIERIHNVAQRVLESVTLGHQVVVVVSAMSGETDRLLEFGKNFSHNPN 61
Query: 63 EREMDTLLAVGEQKAIALFAMTLNKLGYPAVSLCGWQVPIITDNVHTKARIRKIGISRLL 122
+REMD +++VGE + A +M L + G+ A+SL G + I+T + A I+ I R+
Sbjct: 62 KREMDRIVSVGELVSSAALSMALERYGHRAISLSGKEAGILTSSHFQNAVIQSIDTKRIT 121
Query: 123 SLIEEGYIPVVAGFQGVTEDWEITTLGRGGSDTTXXXXXXXXXXD-CEINTDVPGVFTAD 181
L+E+ YI V+AGFQG E TTLGRGGSD + CEI TDV GV+T D
Sbjct: 122 ELLEKNYIVVIAGFQGADIQGETTTLGRGGSDLSAVALAGALKAHLCEIYTDVDGVYTTD 181
Query: 182 PRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEEGTWIVP 241
PRI A+KI +ISY+EMLELAS+GAKV+ RSVE A K +V++ R++F+ EGT IV
Sbjct: 182 PRIEEKAQKIAQISYDEMLELASMGAKVLLNRSVELAKKLSVKLVTRNSFNHSEGTLIVA 241
Query: 242 E----DEVMEKVAVRGITVDTKETRFTVVRVPDKPGIAAEIFKALGDAHIVVDMIVQNVS 297
E E ME V GI +D + R ++ V D+PGIAAEIF AL + I VDMIVQ +
Sbjct: 242 EKDFKGERMETPIVSGIALDKNQARVSMEGVEDRPGIAAEIFGALAEYRINVDMIVQTIG 301
Query: 298 HEGYTDMSFTVNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAKISIVGIGMKSAYGVAGR 357
+G TD+ FT+ KT ++ ++ +K ++ + + D+ +AK+SIVG+GMKS GVA
Sbjct: 302 RDGKTDLDFTIVKTQIEETKQALKPFLAQMDS--IDYDENIAKVSIVGVGMKSHSGVASI 359
Query: 358 MFDILARNGINIKAISTSEIKISCLIDEKYAELAVRALH 396
F LA++ INI ISTSEIKIS LID KYAELAVR LH
Sbjct: 360 AFKALAKDNINIMMISTSEIKISVLIDIKYAELAVRTLH 398
gi|4155744 (AE001542) ASPARTOKINASE 2 ALPHA AND BETA SUBUNITS [Helicobacter
pylori J99]
Length = 405
Score = 343 bits (871), Expect = 1e-93
Identities = 191/399 (47%), Positives = 262/399 (64%), Gaps = 7/399 (1%)
Query: 3 ILVQKFGGTSVGTLERIELCAKRVIKALEKGYKPVVVSSAMAGETDSLIELAKKVHPRPP 62
++VQK+GGTS+G++ERI A+RV+++++ G++ VVV SAM+GETD L+E K P
Sbjct: 2 LIVQKYGGTSMGSIERIHNVAQRVLESVKLGHQVVVVVSAMSGETDRLLEFGKNFSHNPN 61
Query: 63 EREMDTLLAVGEQKAIALFAMTLNKLGYPAVSLCGWQVPIITDNVHTKARIRKIGISRLL 122
+REMD +++ GE + A +M L + G+ A+SL G + I+T + A I+ I R+
Sbjct: 62 KREMDRIVSAGEWISSAALSMALERYGHRAISLSGKEAGILTSSHFQNAVIQSIDTQRIT 121
Query: 123 SLIEEGYIPVVAGFQGVTEDWEITTLGRGGSDTTXXXXXXXXXXD-CEINTDVPGVFTAD 181
L+E+ YI V+AGFQG E TTLGRGGSD + CEI TDV GV+T D
Sbjct: 122 ELLEKNYIVVIAGFQGADIQGETTTLGRGGSDLSAVALAGALKAHLCEIYTDVDGVYTTD 181
Query: 182 PRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEEGTWIVP 241
PRI A+KI +ISY+EMLELAS+GAKV+ RSVE A K +V++ R++F+ EGT IV
Sbjct: 182 PRIEEKAQKIAQISYDEMLELASMGAKVLLNRSVELAKKLSVKLVTRNSFNHSEGTLIVA 241
Query: 242 E----DEVMEKVAVRGITVDTKETRFTVVRVPDKPGIAAEIFKALGDAHIVVDMIVQNVS 297
E E ME V GI +D + R ++ V D+PGIAAEIF AL + I VDMIVQ +
Sbjct: 242 EKDFKGERMETPIVSGIALDKNQARVSMEGVEDRPGIAAEIFGALAEYRINVDMIVQTIG 301
Query: 298 HEGYTDMSFTVNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAKISIVGIGMKSAYGVAGR 357
+G TD+ FT+ KT ++ ++ +K ++ + + D+ +AK+SIVG+GMKS GVA
Sbjct: 302 RDGKTDLDFTIVKTQIEETKQALKPFLAQMDS--IDYDENIAKVSIVGVGMKSHSGVASI 359
Query: 358 MFDILARNGINIKAISTSEIKISCLIDEKYAELAVRALH 396
F LA++ INI ISTSEIKIS LID KYAELAVR LH
Sbjct: 360 AFKALAKDNINIMMISTSEIKISVLIDIKYAELAVRTLH 398
sp|P26512|AK_CORGL ASPARTOKINASE (ASPARTATE KINASE) [CONTAINS: ASPARTOKINASE ALPHA
SUBUNIT; ASPARTOKINASE BETA SUBUNIT]
>gi|320521|pir||S15276 aspartate kinase (EC 2.7.2.4)
alpha chain - Corynebacterium glutamicum
>gi|580983|emb|CAA40502| (X57226) aspartate kinase
[Corynebacterium glutamicum]
Length = 421
Score = 341 bits (866), Expect = 5e-93
Identities = 189/402 (47%), Positives = 263/402 (65%), Gaps = 6/402 (1%)
Query: 1 MKILVQKFGGTSVGTLERIELCAKRVIKALEKGYKPVVVSSAMAGETDSLIELAKKVHPR 60
M ++VQK+GG+S+ + ERI A+R++ + G VVV SAM TD L+ELA V+P
Sbjct: 1 MALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVVSAMGDTTDELLELAAAVNPV 60
Query: 61 PPEREMDTLLAVGEQKAIALFAMTLNKLGYPAVSLCGWQVPIITDNVHTKARIRKIGISR 120
PP REMD LL GE+ + AL AM + LG A S G Q ++T H ARI + R
Sbjct: 61 PPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTGSQAGVLTTERHGNARIVDVTPGR 120
Query: 121 LLSLIEEGYIPVVAGFQGVT-EDWEITTLGRGGSDTTXXXXXXXXXXD-CEINTDVPGVF 178
+ ++EG I +VAGFQGV E ++TTLGRGGSDTT D CEI +DV GV+
Sbjct: 121 VREALDEGKICIVAGFQGVNKETRDVTTLGRGGSDTTAVALAAALNADVCEIYSDVDGVY 180
Query: 179 TADPRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEEGTW 238
TADPRIVPNA+K++K+S+EEMLELA++G+K++ +RSVE+A +NV + VRS++S + GT
Sbjct: 181 TADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTL 240
Query: 239 IV--PEDEVMEKVAVRGITVDTKETRFTVVRVPDKPGIAAEIFKALGDAHIVVDMIVQNV 296
I ED +E+ + G+ D E + TV+ + DKPG AA++F+AL DA I +DM++QNV
Sbjct: 241 IAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNV 300
Query: 297 S--HEGYTDMSFTVNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAKISIVGIGMKSAYGV 354
S +G TD++FT ++D +A EI+KK+ + V+ DD+V K+S+VG GMKS GV
Sbjct: 301 SSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGV 360
Query: 355 AGRMFDILARNGINIKAISTSEIKISCLIDEKYAELAVRALH 396
+ L +NI+ ISTSEI+IS LI E + A RALH
Sbjct: 361 TAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALH 402
sp|P41398|AK_CORFL ASPARTOKINASE (ASPARTATE KINASE) [CONTAINS: ASPARTOKINASE ALPHA
SUBUNIT; ASPARTOKINASE BETA SUBUNIT] >gi|289909 (L16848)
aspartokinase [Corynebacterium flavum]
Length = 421
Score = 340 bits (864), Expect = 9e-93
Identities = 189/402 (47%), Positives = 262/402 (65%), Gaps = 6/402 (1%)
Query: 1 MKILVQKFGGTSVGTLERIELCAKRVIKALEKGYKPVVVSSAMAGETDSLIELAKKVHPR 60
M ++VQK+GG+S+ + ERI A+R++ + G VVV SAM TD L+ELA V+P
Sbjct: 1 MALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELAAAVNPV 60
Query: 61 PPEREMDTLLAVGEQKAIALFAMTLNKLGYPAVSLCGWQVPIITDNVHTKARIRKIGISR 120
PP REMD LL GE+ + AL AM + LG A S G Q ++T H ARI + R
Sbjct: 61 PPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTGSQAGVLTTERHGNARIVDVTPGR 120
Query: 121 LLSLIEEGYIPVVAGFQGVT-EDWEITTLGRGGSDTTXXXXXXXXXXD-CEINTDVPGVF 178
+ ++EG I +VAGFQGV E ++TTLGRGGSDTT D CEI +DV GV+
Sbjct: 121 VREALDEGKICIVAGFQGVNKETRDVTTLGRGGSDTTAVALAAALNADVCEIYSDVDGVY 180
Query: 179 TADPRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEEGTW 238
TADPRIVPNA+K++K+S+EEMLELA++G+K++ +RSVE+A +NV + VRS++S + GT
Sbjct: 181 TADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTL 240
Query: 239 IV--PEDEVMEKVAVRGITVDTKETRFTVVRVPDKPGIAAEIFKALGDAHIVVDMIVQNV 296
I ED +E+ + G+ D E + TV+ + DKPG AA++F+AL DA I +DM++QNV
Sbjct: 241 IAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNV 300
Query: 297 S--HEGYTDMSFTVNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAKISIVGIGMKSAYGV 354
S +G TD++FT + D +A EI+KK+ + V+ DD+V K+S+VG GMKS GV
Sbjct: 301 SSVEDGTTDITFTCPRADGRRAMEILKKLQVQGNWTNVLYDDQVDKVSLVGAGMKSHPGV 360
Query: 355 AGRMFDILARNGINIKAISTSEIKISCLIDEKYAELAVRALH 396
+ L +NI+ ISTSEI+IS LI E + A RALH
Sbjct: 361 TAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALH 402
sp|P97151|AK_THETH ASPARTOKINASE (ASPARTATE KINASE) [CONTAINS: ASPARTOKINASE ALPHA
SUBUNIT (ASK-ALPHA); ASPARTOKINASE BETA SUBUNIT
(ASK-BETA)] >gi|3088363|dbj|BAA25848.1| (AB013131)
aspartate kinase alpha subunit [Thermus thermophilus]
Length = 405
Score = 338 bits (857), Expect = 6e-92
Identities = 180/399 (45%), Positives = 261/399 (65%), Gaps = 5/399 (1%)
Query: 1 MKILVQKFGGTSVGTLERIELCAKRVIKALEKGYKPVVVSSAMAGETDSLIELAKKVHPR 60
M ++VQK+GGTSVG LERI A+R+ EKG++ VV SAM TD LI LAK+V+PR
Sbjct: 1 MALVVQKYGGTSVGDLERIHKVAQRIAHYREKGHRLAVVVSAMGHTTDELIALAKRVNPR 60
Query: 61 PPEREMDTLLAVGEQKAIALFAMTLNKLGYPAVSLCGWQVPIITDNVHTKARIRKIGISR 120
PP RE+D L GEQ ++AL +M L +G PA Q+ I TD + ARI ++ +R
Sbjct: 61 PPFRELDLLTTTGEQVSVALLSMQLWAMGIPAKGFVQHQIGITTDGRYGDARILEVNPAR 120
Query: 121 LLSLIEEGYIPVVAGFQGVTEDWEITTLGRGGSDTTX-XXXXXXXXXDCEINTDVPGVFT 179
+ +E+G++ V+AGF G T + EITTLGRGGSDTT +CEI TD GV+T
Sbjct: 121 IREALEQGFVAVIAGFMGTTPEGEITTLGRGGSDTTAVAIAAALGAKECEIYTDTEGVYT 180
Query: 180 ADPRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEEGTWI 239
DP ++P A+K+ I Y++MLE+A+LGA+V+ R+V +A +Y V +HVRS+FS GT +
Sbjct: 181 TDPHLIPEARKLSVIGYDQMLEMAALGARVLHPRAVYYAKRYGVVLHVRSSFSYNPGTLV 240
Query: 240 VPEDEVMEKVAVRGITVDTKETRFTVVRVPDKPGIAAEIFKALGDAHIVVDMIVQNV-SH 298
M+K AV G+ +D + ++ +PD+PGIAA++F+AL + I VDMI+Q V H
Sbjct: 241 KEVAMEMDK-AVTGVALDLDHAQIGLIGIPDQPGIAAKVFQALAERGIAVDMIIQGVPGH 299
Query: 299 E-GYTDMSFTVNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAKISIVGIGMKSAYGVAGR 357
+ M+FTV K A +A E ++ + +IG + ++R D +AK+SIVG+G+ S V +
Sbjct: 300 DPSRQQMAFTVKKDFAQEALEALEPVLAEIGGEAILRPD-IAKVSIVGVGLASTPEVPAK 358
Query: 358 MFDILARNGINIKAISTSEIKISCLIDEKYAELAVRALH 396
MF +A G NI+ I+TSE++IS +I +YAE A+RA+H
Sbjct: 359 MFQAVASTGANIEMIATSEVRISVIIPAEYAEAALRAVH 397
sp|P77991|AK_THEFL ASPARTOKINASE (ASPARTATE KINASE) [CONTAINS: ASPARTOKINASE ALPHA
SUBUNIT (ASK-ALPHA); ASPARTOKINASE BETA SUBUNIT
(ASK-BETA)] >gi|1616997|dbj|BAA07146.1| (D37928)
aspartokinase alpha-2 [Thermus aquaticus]
Length = 405
Score = 337 bits (854), Expect = 1e-91
Identities = 179/399 (44%), Positives = 261/399 (64%), Gaps = 5/399 (1%)
Query: 1 MKILVQKFGGTSVGTLERIELCAKRVIKALEKGYKPVVVSSAMAGETDSLIELAKKVHPR 60
M ++VQK+GGTSVG LERI A+R+ EKG++ VV SAM TD LI LAK+V+PR
Sbjct: 1 MALVVQKYGGTSVGDLERIHKVAQRIAHYREKGHRLAVVVSAMGHTTDELIALAKRVNPR 60
Query: 61 PPEREMDTLLAVGEQKAIALFAMTLNKLGYPAVSLCGWQVPIITDNVHTKARIRKIGISR 120
PP RE+D L GEQ ++AL +M L +G PA Q+ I TD + ARI ++ +R
Sbjct: 61 PPFRELDLLTTTGEQVSVALLSMQLWAMGIPAKGFVQHQIGITTDGRYGDARILEVNPAR 120
Query: 121 LLSLIEEGYIPVVAGFQGVTEDWEITTLGRGGSDTTX-XXXXXXXXXDCEINTDVPGVFT 179
+ +++G++ V+AGF G T + EITTLGRGGSDTT +CEI TD GV+T
Sbjct: 121 IREALDQGFVAVIAGFMGTTPEGEITTLGRGGSDTTAVAIAAALGAKECEIYTDTEGVYT 180
Query: 180 ADPRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEEGTWI 239
DP ++P A+K+ I Y++MLE+A+LGA+V+ R+V +A +Y V +HVRS+FS GT +
Sbjct: 181 TDPHLIPEARKLSVIGYDQMLEMAALGARVLHPRAVYYAKRYGVVLHVRSSFSYNPGTLV 240
Query: 240 VPEDEVMEKVAVRGITVDTKETRFTVVRVPDKPGIAAEIFKALGDAHIVVDMIVQNV-SH 298
M+K AV G+ +D + ++ +PD+PGIAA++F+AL + I VDMI+Q V H
Sbjct: 241 KEVAMEMDK-AVTGVALDLDHAQIGLIGIPDQPGIAAKVFQALAERGIAVDMIIQGVPGH 299
Query: 299 E-GYTDMSFTVNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAKISIVGIGMKSAYGVAGR 357
+ M+FTV K A +A E ++ + +IG + ++R D +AK+SIVG+G+ S V +
Sbjct: 300 DPSRQQMAFTVKKDFAQEALEALEPVLAEIGGEAILRPD-IAKVSIVGVGLASTPEVPAK 358
Query: 358 MFDILARNGINIKAISTSEIKISCLIDEKYAELAVRALH 396
MF +A G NI+ I+TSE++IS +I +YAE A+RA+H
Sbjct: 359 MFQAVASTGANIEMIATSEVRISVIIPAEYAEAALRAVH 397
emb|CAA99580.1| (Z75208) aspartokinase II alpha subunit [Bacillus subtilis]
>gi|2635312|emb|CAB14807| (Z99118) aspartokinase II
alpha subunit (aa 1->408) and beta subunit (aa 246->408)
[Bacillus subtilis]
Length = 408
Score = 335 bits (851), Expect = 3e-91
Identities = 187/397 (47%), Positives = 253/397 (63%), Gaps = 2/397 (0%)
Query: 1 MKILVQKFGGTSVGTLERIELCAKRVIKALEKGYKPVVVSSAMAGETDSLIELAKKVHPR 60
M ++VQKFGGTSVG++E+I+ A R I +KG++ VVV SAM TD L+ LAK + +
Sbjct: 1 MGLIVQKFGGTSVGSVEKIQNAANRAIAEKQKGHQVVVVVSAMGKSTDELVSLAKAISDQ 60
Query: 61 PPEREMDTLLAVGEQKAIALFAMTLNKLGYPAVSLCGWQVPIITDNVHTKARIRKIGISR 120
P +REMD LLA GEQ I+L +M L + GY AVS GWQ I T+ +H ARI I S
Sbjct: 61 PSKREMDMLLATGEQVTISLLSMALQEKGYDAVSYTGWQAGIRTEAIHGNARITDIDTSV 120
Query: 121 LLSLIEEGYIPVVAGFQGVTEDWEITTLGRGGSDTTXXXXXXXXXXD-CEINTDVPGVFT 179
L +E+G I +VAGFQG+TED EITTLGRGGSDTT D C+I TDVPGVFT
Sbjct: 121 LADQLEKGKIVIVAGFQGMTEDCEITTLGRGGSDTTAVALAAALKADKCDIYTDVPGVFT 180
Query: 180 ADPRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEEGTWI 239
DPR V +A+K++ ISY+EMLELA+LGA V+ R+VEFA Y V + VRS+ E GT I
Sbjct: 181 TDPRYVKSARKLEGISYDEMLELANLGAGVLHPRAVEFAKNYQVPLEVRSSTETEAGTLI 240
Query: 240 VPEDEVMEKVAVRGITVDTKETRFTVVRVPDKPGIAAEIFKALGDAHIVVDMIVQNVSHE 299
E + + + VRGI + + TR T+ + + IF L +I VD+I+Q + E
Sbjct: 241 EEESSMEQNLIVRGIAFEDQITRVTIYGLTSGLTTLSTIFTTLAKRNINVDIIIQTQA-E 299
Query: 300 GYTDMSFTVNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAKISIVGIGMKSAYGVAGRMF 359
T +SF+V DAD+ ++++ + +++ + K+AK+SIVG GM S GVA MF
Sbjct: 300 DKTGISFSVKTEDADQTVAVLEEYKDALEFEKIETESKLAKVSIVGSGMVSNPGVAAEMF 359
Query: 360 DILARNGINIKAISTSEIKISCLIDEKYAELAVRALH 396
+LA+ I IK +STSEIK+S ++ E AV +LH
Sbjct: 360 AVLAQKNILIKMVSTSEIKVSTVVSENDMVKAVESLH 396
sp|P08495|AK2_BACSU ASPARTOKINASE 2 (ASPARTOKINASE II) (ASPARTATE KINASE 2) [CONTAINS:
ASPARTOKINASE II ALPHA SUBUNIT; ASPARTOKINASE II BETA
SUBUNIT] >gi|80248|pir||A29314 aspartate kinase (EC
2.7.2.4) II precursor - Bacillus subtilis >gi|142523
(J03294) aspartokinase II alpha subunit [Bacillus
subtilis]
Length = 408
Score = 335 bits (850), Expect = 4e-91
Identities = 187/397 (47%), Positives = 253/397 (63%), Gaps = 2/397 (0%)
Query: 1 MKILVQKFGGTSVGTLERIELCAKRVIKALEKGYKPVVVSSAMAGETDSLIELAKKVHPR 60
M ++VQKFGGTSVG++E+I+ A R I +KG++ VVV SAM TD L+ LAK + +
Sbjct: 1 MGLIVQKFGGTSVGSVEKIQNAANRAIAEKQKGHQVVVVVSAMGKSTDELVSLAKAISDQ 60
Query: 61 PPEREMDTLLAVGEQKAIALFAMTLNKLGYPAVSLCGWQVPIITDNVHTKARIRKIGISR 120
P +REMD LLA GEQ I+L +M L + GY AVS GWQ I T+ +H ARI I S
Sbjct: 61 PSKREMDMLLATGEQVTISLLSMALQEKGYDAVSYTGWQAGIRTEAIHGNARITDIDTSV 120
Query: 121 LLSLIEEGYIPVVAGFQGVTEDWEITTLGRGGSDTTXXXXXXXXXXD-CEINTDVPGVFT 179
L +E+G I +VAGFQG+TED EITTLGRGGSDTT D C+I TDVPGVFT
Sbjct: 121 LADQLEKGKIVIVAGFQGMTEDCEITTLGRGGSDTTAVALAAALKVDKCDIYTDVPGVFT 180
Query: 180 ADPRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEEGTWI 239
DPR V +A+K++ ISY+EMLELA+LGA V+ R+VEFA Y V + VRS+ E GT I
Sbjct: 181 TDPRYVKSARKLEGISYDEMLELANLGAGVLHPRAVEFAKNYQVPLEVRSSTETEAGTLI 240
Query: 240 VPEDEVMEKVAVRGITVDTKETRFTVVRVPDKPGIAAEIFKALGDAHIVVDMIVQNVSHE 299
E + + + VRGI + + TR T+ + + IF L +I VD+I+Q + E
Sbjct: 241 EEESSMEQNLIVRGIAFEDQITRVTIYGLTSGLTTLSTIFTTLAKRNINVDIIIQTQA-E 299
Query: 300 GYTDMSFTVNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAKISIVGIGMKSAYGVAGRMF 359
T +SF+V DAD+ ++++ + +++ + K+AK+SIVG GM S GVA MF
Sbjct: 300 DKTGISFSVKTEDADQTVAVLEEYKDALEFEKIETESKLAKVSIVGSGMVSNPGVAAEMF 359
Query: 360 DILARNGINIKAISTSEIKISCLIDEKYAELAVRALH 396
+LA+ I IK +STSEIK+S ++ E AV +LH
Sbjct: 360 AVLAQKNILIKMVSTSEIKVSTVVSENDMVKAVESLH 396
sp|Q59229|AK2_BACSP ASPARTOKINASE 2 (ASPARTOKINASE II) (ASPARTATE KINASE 2) [CONTAINS:
ASPARTOKINASE II ALPHA SUBUNIT; ASPARTOKINASE II BETA
SUBUNIT] >gi|1075793|pir||A48946 aspartate kinase (EC
2.7.2.4) II precursor - Bacillus sp. (strain MGA3)
>gi|142540 (M93419) aspartokinase II [Bacillus sp.]
Length = 411
Score = 334 bits (848), Expect = 7e-91
Identities = 182/397 (45%), Positives = 250/397 (62%), Gaps = 1/397 (0%)
Query: 1 MKILVQKFGGTSVGTLERIELCAKRVIKALEKGYKPVVVSSAMAGETDSLIELAKKVHPR 60
M ++VQKFGGTSVG++ERI A RVI+ + G VVV SAM TD L++LAK++
Sbjct: 1 MGLIVQKFGGTSVGSVERILNVANRVIEEKKNGNDVVVVVSAMGKTTDELVDLAKQISAH 60
Query: 61 PPEREMDTLLAVGEQKAIALFAMTLNKLGYPAVSLCGWQVPIITDNVHTKARIRKIGISR 120
PP+REMD LL GEQ I+L AM LN+ GY A+S GWQ I T+ V ARI I +
Sbjct: 61 PPKREMDMLLTTGEQVTISLLAMALNEKGYEAISYTGWQAGITTEPVFGNARILNIETEK 120
Query: 121 LLSLIEEGYIPVVAGFQGVTEDWEITTLGRGGSDTTXXXXXXXXXXD-CEINTDVPGVFT 179
+ + EG I VVAGFQG+ E EITTLGRGGSDTT + C+I TDV GVFT
Sbjct: 121 IQKQLNEGKIVVVAGFQGIDEHGEITTLGRGGSDTTAVALAAALKAEKCDIYTDVTGVFT 180
Query: 180 ADPRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEEGTWI 239
DPR V +A+K+ ISY+EMLELA+LGA V+ R+VEFA Y + + VRS+ EEGT I
Sbjct: 181 TDPRYVKSARKLASISYDEMLELANLGAGVLHPRAVEFAKNYGITLEVRSSMEREEGTII 240
Query: 240 VPEDEVMEKVAVRGITVDTKETRFTVVRVPDKPGIAAEIFKALGDAHIVVDMIVQNVSHE 299
E + + + VRG+ + + TR TV +P+ + IF L I VD+I+Q+ +
Sbjct: 241 EEEVTMEQNLVVRGVAFEDEITRVTVFGLPNSLTSLSTIFTTLAQNRINVDIIIQSATDA 300
Query: 300 GYTDMSFTVNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAKISIVGIGMKSAYGVAGRMF 359
T++SF++ D ++ +++ + + + + +AK+SIVG GM S GVA +MF
Sbjct: 301 ETTNLSFSIKSDDLEETMAVLENNKNLLNYQGIESETGLAKVSIVGSGMISNPGVAAKMF 360
Query: 360 DILARNGINIKAISTSEIKISCLIDEKYAELAVRALH 396
++LA NGI +K +STSEIK+S +++E AV ALH
Sbjct: 361 EVLALNGIQVKMVSTSEIKVSTVVEESQMIKAVEALH 397
sp|P97048|AK_MYCTU ASPARTOKINASE (ASPARTATE KINASE) [CONTAINS: ASPARTOKINASE ALPHA
SUBUNIT (ASK-ALPHA); ASPARTOKINASE BETA SUBUNIT
(ASK-BETA)] >gi|2960133|emb|CAA18031.1| (AL022121) ask
[Mycobacterium tuberculosis]
Length = 421
Score = 332 bits (841), Expect = 4e-90
Identities = 178/402 (44%), Positives = 262/402 (64%), Gaps = 6/402 (1%)
Query: 1 MKILVQKFGGTSVGTLERIELCAKRVIKALEKGYKPVVVSSAMAGETDSLIELAKKVHPR 60
M ++VQK+GG+SV ERI A+R++ ++G VVV SAM TD L++LA++V P
Sbjct: 1 MALVVQKYGGSSVADAERIRRVAERIVATKKQGNDVVVVVSAMGDTTDDLLDLAQQVCPA 60
Query: 61 PPEREMDTLLAVGEQKAIALFAMTLNKLGYPAVSLCGWQVPIITDNVHTKARIRKIGISR 120
PP RE+D LL GE+ + AL AM + LG A S G Q +IT H A+I + R
Sbjct: 61 PPPRELDMLLTAGERISNALVAMAIESLGAHARSFTGSQAGVITTGTHGNAKIIDVTPGR 120
Query: 121 LLSLIEEGYIPVVAGFQGVTEDW-EITTLGRGGSDTTXXXXXXXXXXD-CEINTDVPGVF 178
L + +EEG + +VAGFQGV++D ++TTLGRGGSDTT D CEI TDV G+F
Sbjct: 121 LQTALEEGRVVLVAGFQGVSQDTKDVTTLGRGGSDTTAVAMAAALGADVCEIYTDVDGIF 180
Query: 179 TADPRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEEGTW 238
+ADPRIV NA+K+ +++EEMLE+A+ GAKV+ +R VE+A ++N+ +HVRS++S+ GT
Sbjct: 181 SADPRIVRNARKLDTVTFEEMLEMAACGAKVLMLRCVEYARRHNIPVHVRSSYSDRPGTV 240
Query: 239 IVP--EDEVMEKVAVRGITVDTKETRFTVVRVPDKPGIAAEIFKALGDAHIVVDMIVQNV 296
+V +D ME + G+ D E + T+V +PD PG AA++F+A+ DA + +DM++QNV
Sbjct: 241 VVGSIKDVPMEDPILTGVAHDRSEAKVTIVGLPDIPGYAAKVFRAVADADVNIDMVLQNV 300
Query: 297 S--HEGYTDMSFTVNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAKISIVGIGMKSAYGV 354
S +G TD++FT ++ A E + + +IG +++ DD + K+S++G GM+S GV
Sbjct: 301 SKVEDGKTDITFTCSRDVGPAAVEKLDSLRNEIGFSQLLYDDHIGKVSLIGAGMRSHPGV 360
Query: 355 AGRMFDILARNGINIKAISTSEIKISCLIDEKYAELAVRALH 396
+ LA G+NI+ ISTSEI+IS L + + AV ALH
Sbjct: 361 TATFCEALAAVGVNIELISTSEIRISVLCRDTELDKAVVALH 402
dbj|BAA18676| (D90916) aspartate kinase [Synechocystis sp.]
Length = 600
Score = 329 bits (835), Expect = 2e-89
Identities = 179/412 (43%), Positives = 266/412 (64%), Gaps = 17/412 (4%)
Query: 1 MKILVQKFGGTSVGTLERIELCAKRVIKALEKGYKPVVVSSAMAGETDSLIELAKKVHPR 60
M ++VQKFGGTSVGT+ERI+ A+R+ + ++ G VVV SAM TD L++LA+++ P
Sbjct: 1 MALIVQKFGGTSVGTVERIQAVAQRIKRTVQGGNSLVVVVSAMGKSTDVLVDLAQQISPN 60
Query: 61 PPEREMDTLLAVGEQKAIALFAMTLNKLGYPAVSLCGWQVPIITDNVHTKARIRKIGISR 120
P REMD LL+ GEQ +IAL ++ L ++ PA+SL G QV I+T+ H++ARI +I R
Sbjct: 61 PCRREMDMLLSTGEQVSIALLSLALQEIDQPAISLTGAQVGIVTEAEHSRARILEIRPDR 120
Query: 121 LLSLIEEGYIPVVAGFQGVT--EDWEITTLGRGGSDTTXXXXXXXXXXD-CEINTDVPGV 177
L + EG + VVAGFQG++ E EITTLGRGGSDT+ D CEI TDVPG+
Sbjct: 121 LEHHLREGKVVVVAGFQGISSVEHLEITTLGRGGSDTSAVALAAALKADFCEIYTDVPGI 180
Query: 178 FTADPRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEEGT 237
T DPR+VP A+ + +I+ +EMLELASLGAKV+ R+VE A Y + + VRS++S+E GT
Sbjct: 181 LTTDPRLVPEAQLMAEITCDEMLELASLGAKVLHPRAVEIARNYGIPLVVRSSWSDEPGT 240
Query: 238 WIVPEDEVMEKV-------AVRGITVDTKETRFTVVRVPDKPGIAAEIFKALGDAHIVVD 290
+V + AV G+ D + + ++RVPD+PG+A+++F+ + + +D
Sbjct: 241 KVVAPPVQNRSLVGLEIAKAVDGVEYDADQAKVALLRVPDRPGVASKLFRDIAQQQVDID 300
Query: 291 MIVQNVSHEGYTDMSFTVNKTDADKAEEIVKKIAQKIGA-------KEVVRDDKVAKISI 343
+I+Q++ D++FTV K + AE + IA + + E++ + +AKI+I
Sbjct: 301 LIIQSIHDGNSNDIAFTVVKDLLNTAEAVTSAIAPALRSYPEADQEAEIIVEKGIAKIAI 360
Query: 344 VGIGMKSAYGVAGRMFDILARNGINIKAISTSEIKISCLIDEKYAELAVRAL 395
G GM G+A +MF LA G+NI+ ISTSE+K+SC+ID++ A+ A+ AL
Sbjct: 361 AGAGMIGRPGIAAKMFKTLADVGVNIEMISTSEVKVSCVIDQRDADRAIAAL 412
Score = 107 bits (264), Expect = 2e-22
Identities = 61/165 (36%), Positives = 98/165 (58%), Gaps = 5/165 (3%)
Query: 250 AVRGITVDTKETRFTVVRVPDKPGIAAEIFKALGDAHIVVDMIVQNVS---HEGYT--DM 304
AVRG+ +D + + + VPD+PG+AA++F AL +A+I VDMI+Q+ ++G D+
Sbjct: 434 AVRGVALDQDQAQIAIRHVPDRPGMAAQLFTALAEANISVDMIIQSQRCRINQGTPCRDI 493
Query: 305 SFTVNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAKISIVGIGMKSAYGVAGRMFDILAR 364
+F V + D+ +AE I++ + + +V + +AK+SIVG GM GVA F LA+
Sbjct: 494 AFMVAEGDSSQAEAILQPLIKDWLDAAIVVNKAIAKVSIVGSGMIGHPGVAAHFFAALAQ 553
Query: 365 NGINIKAISTSEIKISCLIDEKYAELAVRALHXXXXXXXXXXXTI 409
INI+ I+TSEIKISC++ + A++A H T+
Sbjct: 554 ENINIEMIATSEIKISCVVPQDRGVDALKAAHSAFNLAGTKTVTV 598
gb|AAD35632.1|AE001729_12 (AE001729) aspartokinase II [Thermotoga maritima]
Length = 739
Score = 312 bits (792), Expect = 2e-84
Identities = 166/395 (42%), Positives = 248/395 (62%), Gaps = 4/395 (1%)
Query: 3 ILVQKFGGTSVGTLERIELCAKRVIKALEKGYKPVVVSSAMAGETDSLIELAKKVHPRPP 62
++V KFGG ++ +E++E A+++IK + G KPVVV SAM TD LIELAK + P
Sbjct: 340 VVVMKFGGAAISDVEKLEKVAEKIIKRKKSGVKPVVVLSAMGDTTDHLIELAKTIDENPD 399
Query: 63 EREMDTLLAVGEQKAIALFAMTLNKLGYPAVSLCGWQVPIITDNVHTKARIRKIGISRLL 122
RE+D LL+ GE +++AL ++ L K GY A+S G Q+ IITD + ARI I +
Sbjct: 400 PRELDLLLSTGEIQSVALMSIALRKRGYKAISFTGNQLKIITDKRYGSARIIDINTDIIS 459
Query: 123 SLIEEGYIPVVAGFQGVTEDWEITTLGRGGSDTTXXXXXXXXXXD-CEINTDVPGVFTAD 181
+++ +IPVVAGFQG+TE +ITTLGRGGSD T D CE+ DV GV+TAD
Sbjct: 460 RYLKQDFIPVVAGFQGITETGDITTLGRGGSDLTAIALAYSLGADLCELYKDVDGVYTAD 519
Query: 182 PRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEEGTWIVP 241
PRIV +A+ IK++S+EEM+EL+ GA+V+Q R+ EFA KY V++ +++ E GT ++
Sbjct: 520 PRIVKDARVIKELSWEEMIELSRHGAQVLQARAAEFARKYGVKVLIKNAHKETRGT-LIW 578
Query: 242 EDEVMEKVAVRGITVDTKETRFTVVRVPDKPGIAAEIFKALGDAHIVVDMIVQNVSHEGY 301
E +E VR +T + + + VPDKPG+AA I + L + +DMI+Q + Y
Sbjct: 579 EGTKVENPIVRAVTFEDGMAKVVLKDVPDKPGVAARIMRTLSQMGVNIDMIIQGMKSGEY 638
Query: 302 TDMSFTVNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAKISIVGIGMKSAYGVAGRMFDI 361
++F V ++ K + + + + AKE++ + +AK+SIVG+ + S ++ +F+
Sbjct: 639 NTVAFIVPESQLGKLD--IDLLKTRSEAKEIIIEKGLAKVSIVGVNLTSTPEISATLFET 696
Query: 362 LARNGINIKAISTSEIKISCLIDEKYAELAVRALH 396
LA GINI IS S +IS +ID KY E AV+A+H
Sbjct: 697 LANEGINIDMISASSSRISVIIDGKYVEDAVKAIH 731
gb|AAD36585.1|AE001799_17 (AE001799) aspartokinase II [Thermotoga maritima]
Length = 401
Score = 305 bits (772), Expect = 6e-82
Identities = 171/396 (43%), Positives = 249/396 (62%), Gaps = 2/396 (0%)
Query: 1 MKILVQKFGGTSVGTLERIELCAKRVIKALEKGYKPVVVSSAMAGETDSLIELAKKVHPR 60
M ++VQK+GG+SV T ERI+ A+R+ K +++GYK VVV SAM TD+LI+LAK++ PR
Sbjct: 1 MNVVVQKYGGSSVATPERIKNVAQRIKKKVDEGYKVVVVVSAMGKTTDNLIKLAKEISPR 60
Query: 61 PPEREMDTLLAVGEQKAIALFAMTLNKLGYPAVSLCGWQVPIITDNVHTKARIRKIGISR 120
P RE+D LLA GEQ + AL +M L LG A SL +QV I T HT ARI I S
Sbjct: 61 PDSRELDMLLATGEQVSAALLSMALKDLGVKAKSLNAFQVKIKTTPHHTSARIVDIDDSV 120
Query: 121 LLSLIEEGYIPVVAGFQGVTEDWEITTLGRGGSDTTXXXXXXXXXXDCEINTDVPGVFTA 180
+ +++ + VV GFQGV E ++TTLGRGGSDT+ CEI +DV G++T
Sbjct: 121 IRENLKDYDVLVVTGFQGVNEHGDLTTLGRGGSDTSAVALAAKLRVPCEIYSDVDGIYTC 180
Query: 181 DPRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEEGTWIV 240
DPR+ P AKK+ I+Y+E LEL +LGAKV+ RSVE A KY + I+ S+F+EEEGT +V
Sbjct: 181 DPRVHPRAKKLAYITYDEALELTALGAKVLHSRSVEIAKKYGIPIYCASSFTEEEGTMVV 240
Query: 241 PE-DEVMEKVAVRGITVDTKETRFTVVRVPDKPGIAAEIFKALGDAHIVVDMIVQNVSHE 299
E +E+ V G T+ + + ++ +P IF+ +G + VDMI V
Sbjct: 241 ERLPEWLEEPVVTGATISHGQIKVSISFLPKDVKYITAIFEEVGKRALNVDMI-SLVPSN 299
Query: 300 GYTDMSFTVNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAKISIVGIGMKSAYGVAGRMF 359
G +SFT+ + + +E +K+ + + + + AK+SIVG+GM+++ GVA R F
Sbjct: 300 GKVFLSFTILEDHKEDLDEALKEALRDVEGWKSTYEGGFAKLSIVGVGMRTSPGVAARFF 359
Query: 360 DILARNGINIKAISTSEIKISCLIDEKYAELAVRAL 395
+ L R G+ + ++TSEIKISCL+ E+ AE A++++
Sbjct: 360 EALERAGVTPELVTTSEIKISCLVPEEKAEEALKSV 395
gi|1899205 (U90239) aspartokinase [Mycobacterium tuberculosis]
Length = 428
Score = 273 bits (691), Expect = 2e-72
Identities = 155/383 (40%), Positives = 232/383 (60%), Gaps = 7/383 (1%)
Query: 1 MKILVQKFGGTSVGTLERIELCAKRVIKALEKGYKPVVVSSAMAGETDSLIELAKKVHPR 60
M ++VQK+GG+SV ERI A+R++ ++G VVV SAM TD L++LA++V P
Sbjct: 1 MALVVQKYGGSSVADAERIRRVAERIVATKKQGNDVVVVVSAMGDTTDDLLDLAQQVCPA 60
Query: 61 PPEREMDTLLAVGEQKAIALFAMTLNKLGYPAVSLCGWQVPIITDNVHTKARIRKIGISR 120
PP RE+D LL GE+ + AL AM + LG A S G Q +IT H A+I + R
Sbjct: 61 PPPRELDMLLTAGERISNALVAMAIESLGAHARSFTGSQAGVITTGTHGNAKIIDVTPGR 120
Query: 121 LLSLIEEGYIPVVAGFQGVTEDW-EITTLGRGGSDTTXXXXXXXXXXD-CEINTDVPGVF 178
L + +EEG + +VAGFQGV++D ++TTLGRGGSDTT D CEI TDV G+F
Sbjct: 121 LQTALEEGRVVLVAGFQGVSQDTKDVTTLGRGGSDTTAVAMAAALGADVCEIYTDVDGIF 180
Query: 179 TADPRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEEGTW 238
+ADPRIV NA+K+ +++EEMLE+A+ GAKV+ +R VE+A ++N+ +HVRS++S+ GT
Sbjct: 181 SADPRIVRNARKLDTVTFEEMLEMAACGAKVLMLRCVEYARRHNIPVHVRSSYSDRPGTV 240
Query: 239 IVP--EDEVMEKVAVRGITVDTKETRFTVVRVPDKPGIAAEIFKALGDAHIV-VDMIVQN 295
+V +D ME + G+ D E + T+V +PD PG AA++F+A+ +
Sbjct: 241 VVGSIKDVPMEDPILTGVAHDRSEAKVTIVGLPDIPGYAAKVFRAVARRRRQHRHGAAER 300
Query: 296 VSHEGYTDMS--FTVNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAKISIVGIGMKSAYG 353
+ G D + +T + + + + +++ DD + K+S++G GM+S G
Sbjct: 301 LQGRGRQDRHHLHLLPQTSGPPPWKNWTRSETRSASTQLLYDDHIGKVSLIGAGMRSHPG 360
Query: 354 VAGRMFDILARNGINIKAISTSE 376
V + LA G+NI+ ISTSE
Sbjct: 361 VTATFCEALAAVGVNIELISTSE 383
sp|Q57991|AK_METJA PROBABLE ASPARTOKINASE (ASPARTATE KINASE) >gi|2127773|pir||C64371
aspartate kinase (EC 2.7.2.4) I - Methanococcus
jannaschii >gi|1591278 (U67506) aspartate kinase (lysC)
[Methanococcus jannaschii]
Length = 473
Score = 218 bits (549), Expect = 8e-56
Identities = 166/465 (35%), Positives = 240/465 (50%), Gaps = 77/465 (16%)
Query: 5 VQKFGGTSVGTLERIELCAKRVIKALEKGYKPVVVSSAMAGETDSLI------------- 51
V KFGGTSVG+ ERI AK V K ++ VVV SAM+ T++L+
Sbjct: 4 VMKFGGTSVGSGERIRHVAKIVTKRKKEDDDVVVVVSAMSEVTNALVEISQQALDVRDIA 63
Query: 52 ----------------------------ELAKKVHPRPPEREM----------------D 67
E+ K + R E E D
Sbjct: 64 KVGDFIKFIREKHYKAIEEAIKSEEIKEEVKKIIDSRIEELEKVLIGVAYLGELTPKSRD 123
Query: 68 TLLAVGEQKAIALFAMTLNKLGYPAVSLCGWQVPIITDNVHTKARIRKIGIS-RLLSLIE 126
+L+ GE+ + + + + LG +++L G + IITDN AR++++ + RLL L++
Sbjct: 124 YILSFGERLSSPILSGAIRDLGEKSIALEGGEAGIITDNNFGSARVKRLEVKERLLPLLK 183
Query: 127 EGYIPVVAGFQGVTEDWEITTLGRGGSDTTXXXXXXXXXXDC-EINTDVPGVFTADPRIV 185
EG IPVV GF G TE+ ITTLGRGGSD + D EI TDV GV+T DPR+V
Sbjct: 184 EGIIPVVTGFIGTTEEGYITTLGRGGSDYSAALIGYGLDADIIEIWTDVSGVYTTDPRLV 243
Query: 186 PNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFS-EEEGTWIVPEDE 244
P A++I K+SY E +ELA GAKV+ R++E A + + I V++TF E EGT I + E
Sbjct: 244 PTARRIPKLSYIEAMELAYFGAKVLHPRTIEPAMEKGIPILVKNTFEPESEGTLITNDME 303
Query: 245 VMEKVAVRGITVDTKETRFTV--VRVPDKPGIAAEIFKALGDAHIVVDMIVQNVSHEGYT 302
+ + + V+ I+ + + G AA IFKALG+ + V +I Q S T
Sbjct: 304 MSDSI-VKAISTIKNVALINIFGAGMVGVSGTAARIFKALGEEEVNVILISQGSSE---T 359
Query: 303 DMSFTVNKTDADKAEEIVKKIAQKIGAK-----EVVRDDKVAK----ISIVGIGMKSAYG 353
++S V++ D DKA + +K+ G K ++RD V K IS+VG GM+ A G
Sbjct: 360 NISLVVSEEDVDKALKALKREFGDFGKKSFLNNNLIRDVSVDKDVCVISVVGAGMRGAKG 419
Query: 354 VAGRMFDILARNGINIKAIS--TSEIKISCLIDEKYAELAVRALH 396
+AG++F ++ +G NIK I+ +SE+ IS +IDEK VR LH
Sbjct: 420 IAGKIFTAVSESGANIKMIAQGSSEVNISFVIDEKDLLNCVRKLH 464
sp|Q9ZCI7|AK_RICPR ASPARTOKINASE (ASPARTATE KINASE) >gi|3861282|emb|CAA15181|
(AJ235273) ASPARTOKINASE (lysC) [Rickettsia prowazekii]
Length = 446
Score = 216 bits (544), Expect = 3e-55
Identities = 145/442 (32%), Positives = 225/442 (50%), Gaps = 48/442 (10%)
Query: 1 MKILVQKFGGTSVGTLERIELCAKRVIKALEKGYKPVVVSSAMAGETDSLIELAKKV--- 57
M +++QKFGGTSV +ERI+ + + K + +VV SAMAG T+ L+ L +V
Sbjct: 1 MALIIQKFGGTSVANVERIKKLVPIIKAEIAKNNQVIVVVSAMAGVTNQLVTLCNEVSSL 60
Query: 58 HPRPPEREMDTLLAVGEQKAIALFAMTLNKLGYPAVSLCGWQVPIITDNVHTKARIRKIG 117
+ R E D L+ GE +L A+ L + A SL WQ+PI T+N ++KA + I
Sbjct: 61 NKRSQFAEYDVALSSGEIVTASLLALALQEEEIKAQSLLAWQLPIRTNNNYSKALVEFIT 120
Query: 118 ISRLLSLIEEGYIPVVAGFQGVTEDWEITTLGRGGSDTTXXXXXXXXXXD-CEINTDVPG 176
L ++ IP++AGFQG+ + +TTLGRGGSDTT D C+I TDV G
Sbjct: 121 TDLLEKYLQLKIIPIIAGFQGINKSNRVTTLGRGGSDTTAALIAAAMKADRCDIYTDVDG 180
Query: 177 VFTADPRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFS-EEE 235
+FTADPRI+PNAK+IK+I + EMLELAS GAKV+ R+VE +Y + + V STFS E
Sbjct: 181 IFTADPRIIPNAKRIKEIDFLEMLELASSGAKVLHPRAVELVMRYKIDMRVLSTFSPNTE 240
Query: 236 GTWIVPEDEV--MEKVAVRGITVDTKETRFTVVRVPD-------KPGIAAEIFKALGDAH 286
GT I +D + ++ + ++TK + T + +P+ K I + +
Sbjct: 241 GTLITSKDTIPLVKSTYMEESALNTKHS--TKIDIPEDASGSTYKLPIELALQNRYNMEN 298
Query: 287 IVVDMIVQNVS--------------------------------HEGYTDMSFTVNKTDAD 314
VV I N + E + +F N TD +
Sbjct: 299 CVVRCITSNKNLLKVSVNSISLSFLQVANMITYNNNCIEFMQEIENNIEYNFITNLTDKN 358
Query: 315 KAEEIVKKIAQKIGAKEVVRDDKVAKISIVGIGMKSAYGVAGRMFDILARNGINIKAIST 374
+ ++ K ++ D ++A IS++G G+K+ + + L ++ IN+ +
Sbjct: 359 NLQTLLTKCKNNKQIQDFTFDTEIATISLIGYGIKNDCKLLTMILSQLTQDNINVHMMQL 418
Query: 375 SEIKISCLIDEKYAELAVRALH 396
SE+KI+ LI++K E + L+
Sbjct: 419 SEVKITLLINDKDVEKTIFNLY 440
pir||S12250 aspartate kinase (EC 2.7.2.4) alpha chain - Corynebacterium
glutamicum (fragment)
Length = 264
Score = 214 bits (539), Expect = 1e-54
Identities = 112/233 (48%), Positives = 162/233 (69%), Gaps = 4/233 (1%)
Query: 168 CEINTDVPGVFTADPRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHV 227
CEI +DV GV+TADPRIVPNA+K++K+S+EEMLELA++G+K++ +RSVE+A +NV + V
Sbjct: 13 CEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRV 72
Query: 228 RSTFSEEEGTWIV--PEDEVMEKVAVRGITVDTKETRFTVVRVPDKPGIAAEIFKALGDA 285
RS++S + GT I ED +E+ + G+ D E + TV+ + DKPG AA++F+AL DA
Sbjct: 73 RSSYSNDPGTLIAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADA 132
Query: 286 HIVVDMIVQNV--SHEGYTDMSFTVNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAKISI 343
I +DM++QNV +G TD++FT ++D +A EI+KK+ + V+ DD+V K+S+
Sbjct: 133 EINIDMVLQNVYSVEDGTTDITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSL 192
Query: 344 VGIGMKSAYGVAGRMFDILARNGINIKAISTSEIKISCLIDEKYAELAVRALH 396
VG GMKS GV + L +NI+ ISTSEI+IS LI E + A RALH
Sbjct: 193 VGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALH 245
gi|3128465 (AF061757) aspartokinase [Pseudomonas aeruginosa]
Length = 215
Score = 209 bits (526), Expect = 4e-53
Identities = 109/202 (53%), Positives = 145/202 (70%), Gaps = 2/202 (0%)
Query: 197 EEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEEGTWIV--PEDEVMEKVAVRGI 254
EEMLE+ASLG+KV+QIR+VEFA KYNV + V +F E GT I E+E ME+ + GI
Sbjct: 1 EEMLEMASLGSKVLQIRAVEFAGKYNVPLRVLHSFQEGPGTLITIDDEEESMEQPIISGI 60
Query: 255 TVDTKETRFTVVRVPDKPGIAAEIFKALGDAHIVVDMIVQNVSHEGYTDMSFTVNKTDAD 314
+ E + T+ VPD PG+A +I + A++ VDMIVQNV+H+ TD +FTV++ D
Sbjct: 61 AFNRDEAKLTIRGVPDTPGVAFKILGPISAANVEVDMIVQNVAHDNTTDFTFTVHRNDYL 120
Query: 315 KAEEIVKKIAQKIGAKEVVRDDKVAKISIVGIGMKSAYGVAGRMFDILARNGINIKAIST 374
A EI+K+ A IGA+E + D +AK+SIVG+GM+S GVA RMF+ LA+ INI+ IST
Sbjct: 121 NALEILKQTAANIGAREAIGDTNIAKVSIVGVGMRSHAGVASRMFEALAKESINIQMIST 180
Query: 375 SEIKISCLIDEKYAELAVRALH 396
SEIK+S +I+EKY ELAVRALH
Sbjct: 181 SEIKVSVVIEEKYLELAVRALH 202
sp|Q04795|AK1_BACSU ASPARTOKINASE 1 (ASPARTOKINASE I) (ASPARTATE KINASE 1) [CONTAINS:
ASPARTOKINASE I ALPHA SUBUNIT; ASPARTOKINASE I BETA
SUBUNIT] >gi|2634048|emb|CAB13549| (Z99112)
aspartokinase I (alpha and beta subunits) [Bacillus
subtilis]
Length = 404
Score = 202 bits (508), Expect = 5e-51
Identities = 152/407 (37%), Positives = 208/407 (50%), Gaps = 21/407 (5%)
Query: 1 MKILVQKFGGTSVGTLERIELCAKRVIKALEKGYKPVVVSSAMAGE-----TDSLIELAK 55
MKI+VQKFGGTSV + +L + +A+ +GYK VVV SAM + TDSL+ L
Sbjct: 1 MKIIVQKFGGTSVKDDKGRKLALGHIKEAISEGYKVVVVVSAMGRKGDPYATDSLLGLLY 60
Query: 56 KVHPRPPEREMDTLLAVGEQKAIALFAMTLNKLGYPAVSLCGWQVPIITDNVHTKARIRK 115
RE D LL+ GE + +F L G A +L G Q +T++ HT A+I +
Sbjct: 61 GDQSAISPREQDLLLSCGETISSVVFTSMLLDNGVKAAALTGAQAGFLTNDQHTNAKIIE 120
Query: 116 IGISRLLSLIEEGYIPVVAGFQGVTEDWEITTLGRGGSDTTXXXXXXXXXXD-CEINTDV 174
+ RL S++ VVAGFQG TE + TT+GRGGSDT+ + +I TDV
Sbjct: 121 MKPERLFSVLANHDAVVVAGFQGATEKGDTTTIGRGGSDTSAAALGAAVDAEYIDIFTDV 180
Query: 175 PGVFTADPRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEE 234
GV TADPR+V NAK + ++Y E+ LA GAKV+ R+VE A + V I VRST+S +
Sbjct: 181 EGVMTADPRVVENAKPLPVVTYTEICNLAYQGAKVISPRAVEIAMQAKVPIRVRSTYSND 240
Query: 235 EGTWIVP--EDEVMEKVAVRGITVDTKETRFTVVRVPDKPG---IAAEIFKALGDAHIVV 289
+GT + +V V R IT T +VP K G + E+FKA+ +A I V
Sbjct: 241 KGTLVTSHHSSKVGSDVFERLITGIAHVKDVTQFKVPAKIGQYNVQTEVFKAMANAGISV 300
Query: 290 DMIVQNVSHEGYTDMSFTVNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAKISIVGIGMK 349
D S YT NKT E ++I +G +V + AK+S VG G+
Sbjct: 301 DFFNITPSEIVYT---VAGNKT------ETAQRILMDMGYDPMVTRN-CAKVSAVGAGIM 350
Query: 350 SAYGVAGRMFDILARNGINIKAISTSEIKISCLIDEKYAELAVRALH 396
GV ++ L+ I I + S I L+ E AV ALH
Sbjct: 351 GVPGVTSKIVSALSEKEIPILQSADSHTTIWVLVHEADMVPAVNALH 397
pir||C46665 aspartate kinase (EC 2.7.2.4) I - Bacillus subtilis >gi|142829
(L08471) aspartokinase I [Bacillus subtilis]
Length = 404
Score = 202 bits (508), Expect = 5e-51
Identities = 152/407 (37%), Positives = 208/407 (50%), Gaps = 21/407 (5%)
Query: 1 MKILVQKFGGTSVGTLERIELCAKRVIKALEKGYKPVVVSSAMAGE-----TDSLIELAK 55
MKI+VQKFGGTSV + +L + +A+ +GYK VVV SAM + TDSL+ L
Sbjct: 1 MKIIVQKFGGTSVKDDKGRKLALGHIKEAISEGYKVVVVVSAMGRKGDPYATDSLLGLLY 60
Query: 56 KVHPRPPEREMDTLLAVGEQKAIALFAMTLNKLGYPAVSLCGWQVPIITDNVHTKARIRK 115
RE D LL+ GE + +F L G A +L G Q +T++ HT A+I +
Sbjct: 61 GDQSAISPREQDLLLSCGETISSVVFTSMLLDNGVKAAALTGAQAGFLTNDQHTNAKIIE 120
Query: 116 IGISRLLSLIEEGYIPVVAGFQGVTEDWEITTLGRGGSDTTXXXXXXXXXXD-CEINTDV 174
+ RL S++ VVAGFQG TE + TT+GRGGSDT+ + +I TDV
Sbjct: 121 MKPERLFSVLANHDAVVVAGFQGATEKGDTTTIGRGGSDTSAAALGAAVDAEYIDIFTDV 180
Query: 175 PGVFTADPRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEE 234
GV TADPR+V NAK + ++Y E+ LA GAKV+ R+VE A + V I VRST+S +
Sbjct: 181 EGVMTADPRVVENAKPLPVVTYTEICNLAYQGAKVISPRAVEIAMQAKVPIRVRSTYSND 240
Query: 235 EGTWIVP--EDEVMEKVAVRGITVDTKETRFTVVRVPDKPG---IAAEIFKALGDAHIVV 289
+GT + +V V R IT T +VP K G + E+FKA+ +A I V
Sbjct: 241 KGTLVTSHHSSKVGSDVFERLITGIAHVKDVTQFKVPAKIGQYNVQTEVFKAMANAGISV 300
Query: 290 DMIVQNVSHEGYTDMSFTVNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAKISIVGIGMK 349
D S YT NKT E ++I +G +V + AK+S VG G+
Sbjct: 301 DFFNITPSEIVYT---VAGNKT------ETAQRILMDMGYDPMVTRN-CAKVSAVGAGIM 350
Query: 350 SAYGVAGRMFDILARNGINIKAISTSEIKISCLIDEKYAELAVRALH 396
GV ++ L+ I I + S I L+ E AV ALH
Sbjct: 351 GVPGVTSKIVSALSEKEIPILQSADSHTTIWVLVHEADMVPAVNALH 397
gi|2649914 (AE001056) aspartate kinase (lysC) [Archaeoglobus fulgidus]
Length = 462
Score = 166 bits (416), Expect = 3e-40
Identities = 141/465 (30%), Positives = 219/465 (46%), Gaps = 84/465 (18%)
Query: 4 LVQKFGGTSVGTLERIELCAKRVIKALEKGYKPVVVSSAMAGETDSLIELAKKVHPRPP- 62
+V KFGG SV E I CA ++K +G + VVV SAM G TD+L++ A + P
Sbjct: 3 IVMKFGGVSVKDGENIYHCAN-LVKKFSEGNEVVVVVSAMQGVTDALLKAAHRCCSEPSA 61
Query: 63 -----------------------------------EREMDTL------------------ 69
ER +D L
Sbjct: 62 GFIKMFIADMMKRHYEAIEYAVRNDEIKAKVIAAVERLLDELEKVLLGISYLGELTRRSE 121
Query: 70 ---LAVGEQKAIALFAMTLNKLGYPAVSLCGWQVPIITD----------NVHTKARIRKI 116
++ GE+ + +F+ L LG +V+L G IITD V+T R R
Sbjct: 122 DYIVSFGERLSAPIFSAALLSLGVDSVALTGGDAGIITDRNFGRAKPLPGVYTTIRNR-- 179
Query: 117 GISRLLSLIEEGYIPVVAGFQGVTEDWEITTLGRGGSDTTXXXXXXXXXXD-CEINTDVP 175
+ LL++ + IPVV GF G T+D ITTLGRGGSD T D + +V
Sbjct: 180 -LEPLLTI--KKTIPVVTGFIGATDDGSITTLGRGGSDYTATILAAALDADEVWLWKEVD 236
Query: 176 GVFTADPRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFS-EE 234
G+ T DP+ VPNA+ I +ISY+E +EL+ GAK++ R++E + N+ + +++TF+ +
Sbjct: 237 GIMTCDPKYVPNARVIPEISYQEAMELSHFGAKILHPRALEPVMRKNIPVRIKNTFNPDA 296
Query: 235 EGTWIVPEDEVMEKVAVRGITVDTKETRFTVVRVP-DKPGIAAEIFKALGDAHIVVDMIV 293
GT I P + ++ V+ +++ + V D I +E+F L + + V M+
Sbjct: 297 PGTVIGPTTKDSSEI-VKALSLIPQAGIVNVSGAGFDFAEIMSEVFGRLAEERVNVIMVA 355
Query: 294 QNVSHEGYTDMSFTVNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAKISIVGIGMKSAYG 353
Q+ S ++S V+ D +KA +K + G +V + +A +S VG GM G
Sbjct: 356 QSSSE---LNLSIVVDIRDLEKAYNALKSLEN--GVIKVEKIPYIAVVSAVGSGMAGTPG 410
Query: 354 VAGRMFDILARNGINIKAI--STSEIKISCLIDEKYAELAVRALH 396
VAG++F L +NGIN+ I S SE +S ++D AV+ +H
Sbjct: 411 VAGKIFSALGKNGINVIMISQSCSEYNVSFVVDGSDGVNAVKVVH 455
emb|CAB57346.1| (Y15939) aspartokinase [Dichelobacter nodosus]
Length = 206
Score = 150 bits (374), Expect = 3e-35
Identities = 84/183 (45%), Positives = 115/183 (61%), Gaps = 3/183 (1%)
Query: 113 IRKIGISRLLSLIEEGYIPVVAGFQGVTEDWEITTLGRGGSDTTXXXXXXXXXXD-CEIN 171
I+ I + + G + +VAGFQGV E +ITTLGRGGSDTT D C+I
Sbjct: 1 IQHIDDGAIYRALSAGKVVIVAGFQGVDEAGDITTLGRGGSDTTAVALAAVLKADECQIY 60
Query: 172 TDVPGVFTADPRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTF 231
TDV GV+T DPRI P A+K+++IS+ EMLE+ASLG+KV+QIRSVEFA KY+V + V S+F
Sbjct: 61 TDVDGVYTTDPRIEPRARKLEQISFVEMLEMASLGSKVLQIRSVEFAGKYHVPVRVLSSF 120
Query: 232 SEEE-GTWIVP-EDEVMEKVAVRGITVDTKETRFTVVRVPDKPGIAAEIFKALGDAHIVV 289
S++E GT I E ++E V GI E ++ +PD +I + +G A I +
Sbjct: 121 SDDETGTLISSVEGAIIEATHVTGIAFTRDEVMIQLMHLPDDMNTLYQILRPIGCADISL 180
Query: 290 DMI 292
DM+
Sbjct: 181 DMV 183
gi|2621892 (AE000858) aspartokinase II alpha subunit [Methanobacterium
thermoautotrophicum]
Length = 406
Score = 150 bits (374), Expect = 3e-35
Identities = 121/401 (30%), Positives = 196/401 (48%), Gaps = 28/401 (6%)
Query: 1 MKILVQKFGGTSVGTLERIELCAKRVIKALEKGYKPVVVSSAMAGETDSLIELA-KKVHP 59
M+++V KFGGTS+G RI+ A+ V+K KG K VVV SA+ TD L+++ + +
Sbjct: 1 MELIVAKFGGTSIGNGRRIKKAARSVVKEYMKGRKVVVVVSAINKTTDELLQIVDEAMED 60
Query: 60 RPPEREMDTLLAVGEQKAIALFAMTLNKLGYPAVSLCGW--QVPIITDNVHTKARI---- 113
E+++ ++++GE ++ +F+ + LG + + + + PIITD+ A++
Sbjct: 61 AVTEKQLAEIVSMGEMTSVRIFSSAIEALGVKSEYIDPFMDEWPIITDSNLLNAKVDFEA 120
Query: 114 RKIGISRLLSLIEEGYIPVVAGFQGVTEDWEITTLGRGGSDTTXXXXXXXXXXD-CEINT 172
+ LL L+++G IPVV GF G + ITTLGRGGSD T D I T
Sbjct: 121 TEEKSRELLKLLDQGIIPVVCGFLGRDPNGYITTLGRGGSDITAFLLGHCLKADEVIIVT 180
Query: 173 DVPGVFTADPRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFS 232
DV GV + DP + AKK+ KIS EEM +LA+ GA+V+ A KY
Sbjct: 181 DVGGVMSTDPNKLQGAKKLDKISVEEMRDLATHGAQVLH----PHALKYKDPDIKAKIIG 236
Query: 233 EEEGTWIVPEDEVM---EKVAVRGITVDTKETRFTVV---RVPDKPGIAAEIFKALGDAH 286
E G P E++ + V+ T++ V ++ +KPGI A + L +
Sbjct: 237 FEHGDLSAPGTEIIGPSKNKMVKTTTLNPDPISVVAVVGEKILNKPGILARLTSRLAENS 296
Query: 287 IVVDMIVQNVSHEGYTDMSFTVNKTDADKAEEIVKKIA---QKIGAKEVVRDDKVAKISI 343
I + I G ++ V+K DAD+A ++ + + + + RD +A I+I
Sbjct: 297 INIIGI-----STGQNSVTIFVDKKDADEAHRLLHDVVIADDDLSSLSLGRD--IAMITI 349
Query: 344 VGIGMKSAYGVAGRMFDILARNGINIKAISTSEIKISCLID 384
G+ + L N +NI IS+S+ + +D
Sbjct: 350 SSPDFIDTPGIISEITKPLRDNDLNIVEISSSQTSVVIFVD 390
Score = 44.5 bits (103), Expect = 0.002
Identities = 24/79 (30%), Positives = 42/79 (52%)
Query: 318 EIVKKIAQKIGAKEVVRDDKVAKISIVGIGMKSAYGVAGRMFDILARNGINIKAISTSEI 377
EI+ K+ + D ++ +++VG + + G+ R+ LA N INI IST +
Sbjct: 248 EIIGPSKNKMVKTTTLNPDPISVVAVVGEKILNKPGILARLTSRLAENSINIIGISTGQN 307
Query: 378 KISCLIDEKYAELAVRALH 396
++ +D+K A+ A R LH
Sbjct: 308 SVTIFVDKKDADEAHRLLH 326
gb|AAF10936.1|AE001982_10 (AE001982) aspartate kinase [Deinococcus radiodurans]
Length = 473
Score = 142 bits (355), Expect = 4e-33
Identities = 132/462 (28%), Positives = 211/462 (45%), Gaps = 75/462 (16%)
Query: 2 KILVQKFGGTSVGTLERIELCAKRVIKALEKGYKPVVVSSAMAGETDSLIEL-------- 53
++LV KFGGT++ + I A +++ +G K VVV SAMAG T+ L+ L
Sbjct: 9 RLLVMKFGGTNMQSAHAIRHSASLAGRSVREGVKVVVVVSAMAGVTNGLLHLADAAQSGD 68
Query: 54 ------------------AKKVHPRPPEREMDTLLAVGEQKAIALFAMTL---------- 85
A+++ P + L + E A++ + L
Sbjct: 69 IARANDEIAALRTRHFTAAQELGAAPDSETVRELRELHETLRQAVYGVYLLRELTPRSRD 128
Query: 86 ------NKLGYPAVSLC------------GWQVPIITDNVHTKAR-----IRKIGISRLL 122
+L P +SL G + I+TD AR ++G RL
Sbjct: 129 LIVAFGERLSAPLMSLALEQSGLRARHLTGGEAGILTDTNFGNARPLPGTYERVG-DRLS 187
Query: 123 SLIEEGYIPVVAGFQGVTEDWEITTLGRGGSDTTXXXXXXXXXXDCEINT--DVPGVFTA 180
+ G PV+AGF G TE ITTLGRGG+D + D E+ DV GV +A
Sbjct: 188 GFLSAGVTPVIAGFMGETEQGAITTLGRGGTDFSATIVGKALGAD-EVWAWKDVDGVMSA 246
Query: 181 DPRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEE-EGTWI 239
DPR+V +A I +SY E++ELA GAKV+ +V + + V+S + GT +
Sbjct: 247 DPRVVGDASNIGVLSYGEVMELAYFGAKVLHPLAVTPLQDSGIPLRVKSAADPDFAGTLV 306
Query: 240 VPEDEVMEKVAVRGITVDTKETRFTV--VRVPDKPGIAAEIFKALGDAHIVVDMIVQNVS 297
+ E + V+ +T + TV V P + A +F A+ +I + M+ Q+ S
Sbjct: 307 RSQAEEIPGRPVKAVTAIKNVSLLTVTGAGVLGVPEVIASVFTAIARENITLLMVSQSSS 366
Query: 298 HEGYTDMSFTVNKTDADKAEEIVKK-IAQKIGAKEVVRDDKVAKISIVGIGMKSAYGVAG 356
+++S V DA +A + ++ ++ ++ +E + VA ++IVG GM+ GV+
Sbjct: 367 ---MSNVSLAVPSADAARALQALRAGLSSELNVEET---NGVAVLAIVGSGMRGQQGVSA 420
Query: 357 RMFDILARNGINIKAIS--TSEIKISCLIDEKYAELAVRALH 396
R+F LA INI IS +SE+ IS + + + A A+H
Sbjct: 421 RLFTALASEDINILMISQGSSELNISVALSGEEVDRATAAVH 462
gb|AAF03452.1|AC010797_28 (AC010797) putative aspartate kinase [Arabidopsis thaliana]
>gi|6513929|gb|AAF14833.1|AC011664_15 (AC011664)
putative aspartate kinase [Arabidopsis thaliana]
Length = 559
Score = 136 bits (338), Expect = 4e-31
Identities = 128/458 (27%), Positives = 215/458 (45%), Gaps = 74/458 (16%)
Query: 5 VQKFGGTSVGTLERIELCAKRVIKALEKGYKPVVVSSAMAGETDSLI------------- 51
V KFGG+SV + ER+ AK ++ ++ KPVVV SAMA T+ L+
Sbjct: 86 VMKFGGSSVASAERMIQVAKLILSFPDE--KPVVVLSAMAKTTNKLLMAGEKAVCCGVTN 143
Query: 52 -----ELA--KKVHPRPPE-------------------------------REMDTLLAVG 73
EL+ K++H R R D L++ G
Sbjct: 144 VDTIEELSYIKELHIRTAHELGVETAVIAEHLEGLEQLLKGVAMMKELTLRSRDYLVSFG 203
Query: 74 EQKAIALFAMTLNKLGYPAVSLCGWQVPIITDNVHTKARIRKI---GISRLL--SLIEEG 128
E + LFA LNK+G+ A +++ IIT + T A I + +S+ L +E
Sbjct: 204 ECMSTRLFAAYLNKIGHKARQYDAFEIGIITTDDFTNADILEATYPAVSKKLLGDWSKEN 263
Query: 129 YIPVVAGFQGVTEDWE---ITTLGRGGSDTTXXXXXXXXXX-DCEINTDVPGVFTADPRI 184
+PVV GF G + W +TTLGRGGSD T + ++ DV GV T DP I
Sbjct: 264 ALPVVTGFLG--KGWRSCAVTTLGRGGSDLTATTIGKALGLREIQVWKDVDGVLTCDPNI 321
Query: 185 VPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEEGTWIVPEDE 244
A+ + ++++E ELA GA+V+ S+ A + N+ + V+++++ ++
Sbjct: 322 YCGAQPVPHLTFDEAAELAYFGAQVLHPLSMRPAREGNIPVRVKNSYNPTAPGTVITRSR 381
Query: 245 VMEKVAVRGITVDTKETR--FTVVRVPDKPGIAAEIFKALGDAHIVVDMI-VQNVSHEGY 301
M K + I + T T R+ + G A++F I VD++ VS
Sbjct: 382 DMSKAVLTSIVLKRNVTMLDITSTRMLGQYGFLAKVFSTFEKLGISVDVVATSEVSISLT 441
Query: 302 TDMS-FTVNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAKISIVGIGMKSAYGVAGRMFD 360
D S F + + +++V+++ +KI ++R + IS++G +S++ + + F
Sbjct: 442 LDPSKFCSRELIQHELDQVVEEL-EKIAVVNLLRHRSI--ISLIGNVQRSSF-ILEKGFR 497
Query: 361 ILARNGINIKAIS--TSEIKISCLIDEKYAELAVRALH 396
+L NGIN++ IS S++ IS ++++ AE V+ALH
Sbjct: 498 VLRTNGINVQMISQGASKVNISLIVNDDEAEHCVKALH 535
gi|537245 (U14003) aspartokinase I-homoserine dehydrogenase I [Escherichia
coli] >gi|1786183 (AE000111) aspartokinase I, homoserine
dehydrogenase I [Escherichia coli]
Length = 820
Score = 135 bits (337), Expect = 6e-31
Identities = 105/349 (30%), Positives = 178/349 (50%), Gaps = 21/349 (6%)
Query: 62 PEREMDTLLAVGEQKAIALFAMTLNKLGYPAVSLCGWQVPI-----ITDNVHTKARIRKI 116
P+ L+ GE+ +IA+ A L G+ + + + + V R+I
Sbjct: 115 PDSINAALICRGEKMSIAIMAGVLEARGHNVTVIDPVEKLLAVGHYLESTVDIAESTRRI 174
Query: 117 GISRLLSLIEEGYIPVVAGFQGVTEDWEITTLGRGGSDTTXXXXXXXXXXDC-EINTDVP 175
SR I ++ ++AGF E E+ LGR GSD + DC EI TDV
Sbjct: 175 AASR----IPADHMVLMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVD 230
Query: 176 GVFTADPRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEE 235
GV+T DPR VP+A+ +K +SY+E +EL+ GAKV+ R++ A++ + +++T + +
Sbjct: 231 GVYTCDPRQVPDARLLKSMSYQEAMELSYFGAKVLHPRTITPIAQFQIPCLIKNTGNPQA 290
Query: 236 GTWIVPEDEVMEKVAVRGITVDTKETRFTV--VRVPDKPGIAAEIFKALGDAHIVVDMIV 293
++ +++ V+GI+ F+V + G+AA +F A+ A I V +I
Sbjct: 291 PGTLIGASRDEDELPVKGISNLNNMAMFSVSGPGMKGMVGMAARVFAAMSRARISVVLIT 350
Query: 294 QNVSHEGYTDMSFTVNKTDADKAEEIVKK---IAQKIGAKE-VVRDDKVAKISIVGIGMK 349
Q+ S +SF V ++D +AE +++ + K G E + +++A IS+VG GM+
Sbjct: 351 QSSSE---YSISFCVPQSDCVRAERAMQEEFYLELKEGLLEPLAVTERLAIISVVGDGMR 407
Query: 350 SAYGVAGRMFDILARNGINIKAIS--TSEIKISCLIDEKYAELAVRALH 396
+ G++ + F LAR INI AI+ +SE IS +++ A VR H
Sbjct: 408 TLRGISAKFFAALARANINIVAIAQGSSERSISVVVNNDDATTGVRVTH 456
sp|P00561|AK1H_ECOLI BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYDROGENASE I (AKI-HDI)
[INCLUDES: ASPARTOKINASE ; HOMOSERINE DEHYDROGENASE ]
>gi|66915|pir||DEECK thrA bifunctional enzyme -
Escherichia coli
Length = 820
Score = 132 bits (329), Expect = 5e-30
Identities = 104/349 (29%), Positives = 177/349 (49%), Gaps = 21/349 (6%)
Query: 62 PEREMDTLLAVGEQKAIALFAMTLNKLGYPAVSLCGWQVPI-----ITDNVHTKARIRKI 116
P+ L+ GE+ +IA+ A L G+ + + + + V R+I
Sbjct: 115 PDSINAALICRGEKMSIAIMAGVLEARGHNVTVIDPVEKLLAVGHYLESTVDIAESTRRI 174
Query: 117 GISRLLSLIEEGYIPVVAGFQGVTEDWEITTLGRGGSDTTXXXXXXXXXXDC-EINTDVP 175
SR I ++ ++AGF E E+ LGR GSD + DC EI TDV
Sbjct: 175 AASR----IPADHMVLMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVN 230
Query: 176 GVFTADPRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEE 235
GV+T DPR VP+A+ +K +SY+E +EL+ GAKV+ R++ A++ + +++T + +
Sbjct: 231 GVYTCDPRQVPDARLLKSMSYQEAMELSYFGAKVLHPRTITPIAQFQIPCLIKNTGNPQA 290
Query: 236 GTWIVPEDEVMEKVAVRGITVDTKETRFTV--VRVPDKPGIAAEIFKALGDAHIVVDMIV 293
++ +++ V+GI+ F+V + G+AA +F A+ A I V +I
Sbjct: 291 PGTLIGASRDEDELPVKGISNLNNMAMFSVSGPGMKGMVGMAARVFAAMSRARISVVLIT 350
Query: 294 QNVSHEGYTDMSFTVNKTDADKAEEIVKK---IAQKIGAKE-VVRDDKVAKISIVGIGMK 349
Q+ S +SF V ++D +AE + + + K G E + +++A IS+VG G++
Sbjct: 351 QSSSE---YSISFCVPQSDCVRAERAMLEEFYLELKEGLLEPLAVAERLAIISVVGDGLR 407
Query: 350 SAYGVAGRMFDILARNGINIKAIS--TSEIKISCLIDEKYAELAVRALH 396
+ G++ + F LAR INI AI+ +SE IS +++ A VR H
Sbjct: 408 TLRGISAKFFAALARANINIVAIAQGSSERSISVVVNNDDATTGVRVTH 456
emb|CAA23660| (V00361) thrA gene [EC 2.7.2.4 and EC 1.1.1.3] [Escherichia coli]
>gi|147979 (J01706) aspartokinase I-homoserine
dehydrogenase I [Escherichia coli]
>gi|216435|dbj|BAA01286| (D10483) aspartokinase I
[Escherichia coli]
Length = 820
Score = 132 bits (329), Expect = 5e-30
Identities = 104/349 (29%), Positives = 177/349 (49%), Gaps = 21/349 (6%)
Query: 62 PEREMDTLLAVGEQKAIALFAMTLNKLGYPAVSLCGWQVPI-----ITDNVHTKARIRKI 116
P+ L+ GE+ +IA+ A L G+ + + + + V R+I
Sbjct: 115 PDSINAALICRGEKMSIAIMAGVLEARGHNVTVIDPVEKLLAVGHYLESTVDIAESTRRI 174
Query: 117 GISRLLSLIEEGYIPVVAGFQGVTEDWEITTLGRGGSDTTXXXXXXXXXXDC-EINTDVP 175
SR I ++ ++AGF E E+ LGR GSD + DC EI TDV
Sbjct: 175 AASR----IPADHMVLMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVN 230
Query: 176 GVFTADPRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEE 235
GV+T DPR VP+A+ +K +SY+E +EL+ GAKV+ R++ A++ + +++T + +
Sbjct: 231 GVYTCDPRQVPDARLLKSMSYQEAMELSYFGAKVLHPRTITPIAQFQIPCLIKNTGNPQA 290
Query: 236 GTWIVPEDEVMEKVAVRGITVDTKETRFTV--VRVPDKPGIAAEIFKALGDAHIVVDMIV 293
++ +++ V+GI+ F+V + G+AA +F A+ A I V +I
Sbjct: 291 PGTLIGASRDEDELPVKGISNLNNMAMFSVSGPGMKGMVGMAARVFAAMSRARISVVLIT 350
Query: 294 QNVSHEGYTDMSFTVNKTDADKAEEIVKK---IAQKIGAKE-VVRDDKVAKISIVGIGMK 349
Q+ S +SF V ++D +AE + + + K G E + +++A IS+VG G++
Sbjct: 351 QSSSE---YSISFCVPQSDCVRAERAMLEEFYLELKEGLLEPLAVAERLAIISVVGDGLR 407
Query: 350 SAYGVAGRMFDILARNGINIKAIS--TSEIKISCLIDEKYAELAVRALH 396
+ G++ + F LAR INI AI+ +SE IS +++ A VR H
Sbjct: 408 TLRGISAKFFAALARANINIVAIAQGSSERSISVVVNNDDATTGVRVTH 456
sp|P27725|AK1H_SERMA BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYDROGENASE I (AKI-HDI)
[INCLUDES: ASPARTOKINASE ; HOMOSERINE DEHYDROGENASE ]
>gi|421254|pir||B47057 aspartate kinase (EC 2.7.2.4) I /
homoserine dehydrogenase (EC 1.1.1.3) I - Serratia
marcescens >gi|47273|emb|CAA43212| (X60821) aspartate
kinase [Serratia marcescens]
Length = 819
Score = 130 bits (324), Expect = 2e-29
Identities = 99/346 (28%), Positives = 171/346 (48%), Gaps = 15/346 (4%)
Query: 62 PEREMDTLLAVGEQKAIALFAMTLNKLGYPAVSLCGWQVPIITDN-VHTKARIRKIGISR 120
P+ ++ GE+ +IA+ GYP + + + + + + I + +
Sbjct: 115 PDSVNAAIICRGEKLSIAIMEGVFRAKGYPVTVINPVEKLLAQGHYLESTVDIAESTLRI 174
Query: 121 LLSLIEEGYIPVVAGFQGVTEDWEITTLGRGGSDTTXXXXXXXXXXDC-EINTDVPGVFT 179
+ I +I ++AGF + E+ LGR GSD + DC EI TDV GV+T
Sbjct: 175 AAAAIPADHIVLMAGFTAGNDKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYT 234
Query: 180 ADPRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEEGTWI 239
DPR VP+A+ +K +SY+E +EL+ GAKV+ R++ A++ + +++T + + +
Sbjct: 235 CDPRTVPDARLLKSMSYQEAMELSYFGAKVLHPRTITPIAQFQIPCLIKNTSNPQAPGTL 294
Query: 240 VPEDEVMEKVAVRGITVDTKETRFTV--VRVPDKPGIAAEIFKALGDAHIVVDMIVQNVS 297
+ +D + V+GIT V + G+AA +F + A I V +I Q+ S
Sbjct: 295 IGKDSTDADMPVKGITNLNNMAMINVSGPGMKGMVGMAARVFAVMSRAGISVVLITQSSS 354
Query: 298 HEGYTDMSFTVNKTDADKAEEIVKKIAQKIGAKEVVRD-----DKVAKISIVGIGMKSAY 352
+SF V + + +A +++ + K+ V D +++A IS+VG GM++
Sbjct: 355 E---YSISFCVPQGELQRARRALEE-EFYLELKDGVLDPLDVMERLAIISVVGDGMRTLR 410
Query: 353 GVAGRMFDILARNGINIKAIS--TSEIKISCLIDEKYAELAVRALH 396
G++ R F LAR INI AI+ +SE IS ++ A VR H
Sbjct: 411 GISARFFSALARANINIVAIAQGSSERSISVVVSNDSATTGVRVSH 456
dbj|BAA38477| (D10386) aspartokinase I-homoserine dehydrogenase I [Serratia
marcescens]
Length = 819
Score = 130 bits (324), Expect = 2e-29
Identities = 99/346 (28%), Positives = 171/346 (48%), Gaps = 15/346 (4%)
Query: 62 PEREMDTLLAVGEQKAIALFAMTLNKLGYPAVSLCGWQVPIITDN-VHTKARIRKIGISR 120
P+ ++ GE+ +IA+ GYP + + + + + + I + +
Sbjct: 115 PDSVNAAIICRGEKLSIAIMEGVFRAKGYPVTVINPVEKLLAQGHYLESTVDIAESTLRI 174
Query: 121 LLSLIEEGYIPVVAGFQGVTEDWEITTLGRGGSDTTXXXXXXXXXXDC-EINTDVPGVFT 179
+ I +I ++AGF + E+ LGR GSD + DC EI TDV GV+T
Sbjct: 175 AAAAIPADHIVLMAGFTAGNDKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYT 234
Query: 180 ADPRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEEGTWI 239
DPR VP+A+ +K +SY+E +EL+ GAKV+ R++ A++ + +++T + + +
Sbjct: 235 CDPRTVPDARLLKSMSYQEAMELSYFGAKVLHPRTITPIAQFQIPCLIKNTSNPQAPGTL 294
Query: 240 VPEDEVMEKVAVRGITVDTKETRFTV--VRVPDKPGIAAEIFKALGDAHIVVDMIVQNVS 297
+ +D + V+GIT V + G+AA +F + A I V +I Q+ S
Sbjct: 295 IGKDSTDADMPVKGITNLNNMAMINVSGPGMKGMVGMAARVFAVMSRAGISVVLITQSSS 354
Query: 298 HEGYTDMSFTVNKTDADKAEEIVKKIAQKIGAKEVVRD-----DKVAKISIVGIGMKSAY 352
+SF V + + +A +++ + K+ V D +++A IS+VG GM++
Sbjct: 355 E---YSISFCVPQGELQRARRALEE-EFYLELKDGVLDPLDVMERLAIISVVGDGMRTLR 410
Query: 353 GVAGRMFDILARNGINIKAIS--TSEIKISCLIDEKYAELAVRALH 396
G++ R F LAR INI AI+ +SE IS ++ A VR H
Sbjct: 411 GISARFFSALARANINIVAIAQGSSERSISVVVSNDSATTGVRVSH 456
gi|2257743 (U62020) lysine-sensitive aspartate kinase [Arabidopsis thaliana]
Length = 544
Score = 130 bits (323), Expect = 2e-29
Identities = 122/463 (26%), Positives = 211/463 (45%), Gaps = 82/463 (17%)
Query: 5 VQKFGGTSVGTLERIELCAKRVIKALEKGYKPVVVSSAM---------AGE--------- 46
V KFGG+SVG+ ER++ A + ++ +PV+V SAM AGE
Sbjct: 85 VMKFGGSSVGSAERMKEVANLIFSFPDE--RPVIVLSAMGKTINKLLKAGEKAVTCGVTN 142
Query: 47 TDSLIELA--KKVHPRPPE-------------------------------REMDTLLAVG 73
S+ EL+ K++H R R D L++ G
Sbjct: 143 VGSIEELSFIKELHLRTAHELGVETTVIEKHLEGLHQLLKGISMMKELTLRTRDYLVSFG 202
Query: 74 EQKAIALFAMTLNKLGYPAVSLCGWQVPIITDNVHTKARIRKI---GISRLL--SLIEEG 128
E + LF+ LNK+G+ A +++ IT + T A I + +S+ L +E
Sbjct: 203 ECMSTRLFSAYLNKIGHKARQYDAFEIGFITTDDFTNADILEATYPAVSKTLVGDWSKEN 262
Query: 129 YIPVVAGFQGVTEDWE---ITTLGRGGSDTTXXXXXXXXXX-DCEINTDVPGVFTADPRI 184
+PVV G+ G + W ITTLGRGGSD T + ++ DV GV T DP I
Sbjct: 263 AVPVVTGYLG--KGWRSCAITTLGRGGSDLTATTIGKALGLREIQVWKDVDGVLTCDPNI 320
Query: 185 VPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEEGTWIVPEDE 244
P A+ + ++++E ELA GA+V+ S+ A ++ + V+++++ ++
Sbjct: 321 YPGAQSVPYLTFDEAAELAYFGAQVLHPLSMRPARDGDIPVRVKNSYNPTAPGTVITRSR 380
Query: 245 VMEKVAVRGITVDTKETRFTV--VRVPDKPGIAAEIFKALGDAHIVVDMIVQNVSHEGYT 302
M K + I + T + R+ + G A++F D I VD++ +
Sbjct: 381 DMSKAVLTSIVLKRNVTMLDIASTRMLGQYGFLAKVFTTFEDLGISVDVVATS-----EV 435
Query: 303 DMSFTVNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAK-------ISIVGIGMKSAYGVA 355
+S T++ E+++++ + E + V K IS++G KS+ +
Sbjct: 436 SISLTLDPAKL-WGRELIQRVNELDNLVEELEKIAVVKLLQRRSIISLIGNVQKSSL-IL 493
Query: 356 GRMFDILARNGINIKAIS--TSEIKISCLIDEKYAELAVRALH 396
++F + NG+N++ IS S++ IS +++++ AE VRALH
Sbjct: 494 EKVFQVFRSNGVNVQMISQGASKVNISLIVNDEEAEQCVRALH 536
dbj|BAA38474| (D10385) aspartokinase I-homoserine dehydrogenase I [Serratia
marcescens]
Length = 819
Score = 130 bits (323), Expect = 2e-29
Identities = 100/347 (28%), Positives = 172/347 (48%), Gaps = 17/347 (4%)
Query: 62 PEREMDTLLAVGEQKAIALFAMTLNKLGYPAVSLCGWQVPIITDN-VHTKARIRKIGISR 120
P+ ++ GE+ +IA+ GYP + + + + + + I + +
Sbjct: 115 PDSVNAAIICRGEKLSIAIMEGVFRAKGYPVTVINPVEKLLAQGHYLESTVDIAESTLRI 174
Query: 121 LLSLIEEGYIPVVAGFQGVTEDWEITTLGRGGSDTTXXXXXXXXXXDC-EINTDVPGVFT 179
+ I +I ++AGF + E+ LGR GSD + DC EI TDV GV+T
Sbjct: 175 AAAAIPADHIVLMAGFTAGNDKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYT 234
Query: 180 ADPRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEEGTWI 239
DPR VP+A+ +K +SY+E +EL+ GAKV+ R++ A++ + +++T + + +
Sbjct: 235 CDPRTVPDARLLKSMSYQEAMELSYFGAKVLHPRTITPIAQFQIPCLIKNTSNPQAPGTL 294
Query: 240 VPEDEVMEKVAVRGITVDTKETRFTVVRVPDKPG---IAAEIFKALGDAHIVVDMIVQNV 296
+ +D + V+GIT + V P G +AA +F + A I V +I Q+
Sbjct: 295 IGKDSTDADMPVKGIT-NLNNMAMINVSGPGMKGMVDMAARVFAVMSRAGISVVLITQSS 353
Query: 297 SHEGYTDMSFTVNKTDADKAEEIVKKIAQKIGAKEVVRD-----DKVAKISIVGIGMKSA 351
S +SF V + + +A +++ + K+ V D +++A IS+VG GM++
Sbjct: 354 SE---YSISFCVPQGELQRARRALEE-EFYLELKDGVLDPLDVMERLAIISVVGDGMRTL 409
Query: 352 YGVAGRMFDILARNGINIKAIS--TSEIKISCLIDEKYAELAVRALH 396
G++ R F LAR INI AI+ +SE IS ++ A VR H
Sbjct: 410 RGISARFFSALARANINIVAIAQGSSERSISVVVSNDSATTGVRVSH 456
pir||S15277 aspartate kinase (EC 2.7.2.4) beta chain - Corynebacterium
glutamicum >gi|580984|emb|CAA40503| (X57226) aspartate
kinase [Corynebacterium glutamicum]
Length = 172
Score = 129 bits (322), Expect = 3e-29
Identities = 69/153 (45%), Positives = 99/153 (64%), Gaps = 2/153 (1%)
Query: 246 MEKVAVRGITVDTKETRFTVVRVPDKPGIAAEIFKALGDAHIVVDMIVQNVS--HEGYTD 303
ME+ + G+ D E + TV+ + DKPG AA++F+AL DA I +DM++QNVS +G TD
Sbjct: 1 MEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTD 60
Query: 304 MSFTVNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAKISIVGIGMKSAYGVAGRMFDILA 363
++FT ++D +A EI+KK+ + V+ DD+V K+S+VG GMKS GV + L
Sbjct: 61 ITFTCPRSDGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALR 120
Query: 364 RNGINIKAISTSEIKISCLIDEKYAELAVRALH 396
+NI+ ISTSEI+IS LI E + A RALH
Sbjct: 121 DVNVNIELISTSEIRISVLIREDDLDAAARALH 153
pir||I40835 aspartokinase beta chain - Cornyebacterium lactofermentum
>gi|606994 (L27125) aspartokinase beta-subunit
[Corynebacterium lactofermentum]
Length = 172
Score = 129 bits (320), Expect = 6e-29
Identities = 69/153 (45%), Positives = 98/153 (63%), Gaps = 2/153 (1%)
Query: 246 MEKVAVRGITVDTKETRFTVVRVPDKPGIAAEIFKALGDAHIVVDMIVQNVS--HEGYTD 303
ME+ + G+ D E + TV+ + DKPG AA++F+AL DA I +DM++QNVS +G TD
Sbjct: 1 MEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTD 60
Query: 304 MSFTVNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAKISIVGIGMKSAYGVAGRMFDILA 363
++FT + D +A EI+KK+ + V+ DD+V K+S+VG GMKS GV + L
Sbjct: 61 ITFTCPRADGGRAMEILKKLQVQGNWTNVLYDDQVDKVSLVGAGMKSHPGVTAEFMEALR 120
Query: 364 RNGINIKAISTSEIKISCLIDEKYAELAVRALH 396
+NI+ ISTSEI+IS LI E + A RALH
Sbjct: 121 DVNVNIELISTSEIRISVLIREDDLDAAARALH 153
dbj|BAA38480| (D10387) aspartokinase I-homoserine dehydrogenase I [Serratia
marcescens]
Length = 819
Score = 129 bits (320), Expect = 6e-29
Identities = 99/346 (28%), Positives = 170/346 (48%), Gaps = 15/346 (4%)
Query: 62 PEREMDTLLAVGEQKAIALFAMTLNKLGYPAVSLCGWQVPIITDN-VHTKARIRKIGISR 120
P+ ++ GE+ +IA+ GYP + + + + + + I + +
Sbjct: 115 PDSVNAAIICRGEKLSIAIMEGVFRAKGYPVTVINPVEKLLAQGHYLESTVDIAESTLRI 174
Query: 121 LLSLIEEGYIPVVAGFQGVTEDWEITTLGRGGSDTTXXXXXXXXXXDC-EINTDVPGVFT 179
+ I +I ++AGF + E+ LGR GSD + DC EI TDV GV+T
Sbjct: 175 AAAAIPADHIVLMAGFTAGNDKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYT 234
Query: 180 ADPRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEEGTWI 239
DPR VP+A+ +K +SY+E +EL+ GAKV+ R++ A++ + +++T + + +
Sbjct: 235 CDPRTVPDARLLKSMSYQEAMELSYFGAKVLHPRTITPIAQFQIPCLIKNTSNPQAPGTL 294
Query: 240 VPEDEVMEKVAVRGITVDTKETRFTV--VRVPDKPGIAAEIFKALGDAHIVVDMIVQNVS 297
+ +D + V+GIT V + G+AA +F + A I V +I Q S
Sbjct: 295 IGKDSTDADMPVKGITNLNNMAMINVSGPGMKGMVGMAARVFAVMSRAGISVVLITQFSS 354
Query: 298 HEGYTDMSFTVNKTDADKAEEIVKKIAQKIGAKEVVRD-----DKVAKISIVGIGMKSAY 352
+SF V + + +A +++ + K+ V D +++A IS+VG GM++
Sbjct: 355 E---YSISFCVPQGELQRARRALEE-EFYLELKDGVLDPLDVMERLAIISVVGDGMRTLR 410
Query: 353 GVAGRMFDILARNGINIKAIS--TSEIKISCLIDEKYAELAVRALH 396
G++ R F LAR INI AI+ +SE IS ++ A VR H
Sbjct: 411 GISARFFSALARANINIVAIAQGSSERSISVVVSNDSATTGVRVSH 456
gb|AAD49568.1|AF134837_2 (AF134837) aspartokinase subunit B [Amycolatopsis mediterranei]
Length = 172
Score = 128 bits (319), Expect = 7e-29
Identities = 67/153 (43%), Positives = 99/153 (63%), Gaps = 2/153 (1%)
Query: 246 MEKVAVRGITVDTKETRFTVVRVPDKPGIAAEIFKALGDAHIVVDMIVQNVSH--EGYTD 303
ME+ + G+ D E + TV VPD G AA IF+ + DA I +DM++QNVS G TD
Sbjct: 1 MEQALITGVAHDRSEAKITVTGVPDHTGAAARIFRVIADAEIDIDMVLQNVSSTVSGRTD 60
Query: 304 MSFTVNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAKISIVGIGMKSAYGVAGRMFDILA 363
++FT++K + KA + ++K+ +IG + V+ DD V K+S+VG GM+S GV + LA
Sbjct: 61 ITFTLSKANGAKAVKELEKVQAEIGFESVLYDDHVGKVSVVGAGMRSHPGVTATFCEALA 120
Query: 364 RNGINIKAISTSEIKISCLIDEKYAELAVRALH 396
G+NI+ I+TSEI+IS LI + + AVRA+H
Sbjct: 121 EAGVNIEIINTSEIRISVLIRDAQLDDAVRAIH 153
sp|P44505|AKH_HAEIN BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYDROGENASE (AK-HD)
[INCLUDES: ASPARTOKINASE ; HOMOSERINE DEHYDROGENASE ]
>gi|1073872|pir||A64048 aspartokinase-homoserine
dehydrogenase (thrA) homolog - Haemophilus influenzae
(strain Rd KW20) >gi|1573040 (U32694) aspartokinase I /
homoserine dehydrogenase I (thrA) [Haemophilus
influenzae Rd]
Length = 815
Score = 123 bits (307), Expect = 2e-27
Identities = 93/283 (32%), Positives = 149/283 (51%), Gaps = 16/283 (5%)
Query: 125 IEEGYIPVVAGFQGVTEDWEITTLGRGGSDTTXXXXXXXXXXD-CEINTDVPGVFTADPR 183
I + + ++AGF E E+ LGR GSD + CEI TDV GV+T DPR
Sbjct: 179 IAKDKVVLMAGFTAGNEKGELVLLGRNGSDYSAACLAACLGASVCEIWTDVDGVYTCDPR 238
Query: 184 IVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEEGTWIVPED 243
+VP+A+ + +SY E +EL+ GAKV+ R++ N+ +++T + I+ +
Sbjct: 239 LVPDARLLPTLSYREAMELSYFGAKVIHPRTIGPLLPQNIPCVIKNTGNPSAPGSIIDGN 298
Query: 244 EVMEKVAVRGITVDTKETRFTV--VRVPDKPGIAAEIFKALGDAHIVVDMIVQNVSHEGY 301
E + V+GIT F V + G+A+ +F A+ A I V +I Q+ S
Sbjct: 299 VKSESLQVKGITNLDNLAMFNVSGPGMQGMVGMASRVFSAMSGAGISVILITQSSSE--- 355
Query: 302 TDMSFTVNKTDADKAEEIVK-KIAQKIGAK-----EVVRDDKVAKISIVGIGMKSAYGVA 355
+SF V A+ A+ +++ + A ++ EV++D ++ IS+VG GMK A G+A
Sbjct: 356 YSISFCVPVKSAEVAKTVLETEFANELNEHQLEPIEVIKD--LSIISVVGDGMKQAKGIA 413
Query: 356 GRMFDILARNGINIKAIS--TSEIKISCLIDEKYAELAVRALH 396
R F LA+ I+I AI+ +SE IS ++ + A AV+A H
Sbjct: 414 ARFFSALAQANISIVAIAQGSSERSISAVVPQNKAIEAVKATH 456
emb|CAA78985| (Z17372) aspartokinase [Mycobacterium smegmatis]
Length = 172
Score = 123 bits (305), Expect = 3e-27
Identities = 63/153 (41%), Positives = 97/153 (63%), Gaps = 2/153 (1%)
Query: 246 MEKVAVRGITVDTKETRFTVVRVPDKPGIAAEIFKALGDAHIVVDMIVQNVS--HEGYTD 303
ME + G+ D E + TVV +PD PG AA++F+A+ +A + +DM++QN+S +G TD
Sbjct: 1 MEDAILTGVAHDRSEAKVTVVGLPDVPGYAAKVFRAVAEADVNIDMVLQNISKIEDGKTD 60
Query: 304 MSFTVNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAKISIVGIGMKSAYGVAGRMFDILA 363
++FT + + +A E + + +IG +V+ DD + K+S++G GM+S GV + LA
Sbjct: 61 ITFTCARDNGPRAVEKLSALKSEIGFSQVLYDDHIGKVSLIGAGMRSHPGVTATFCEALA 120
Query: 364 RNGINIKAISTSEIKISCLIDEKYAELAVRALH 396
GINI ISTSEI+IS LI + + AV ALH
Sbjct: 121 EAGINIDLISTSEIRISVLIKDTELDKAVSALH 153
gb|AAD41796.1| (AF135862) precursor monofunctional aspartokinase [Glycine max]
Length = 564
Score = 120 bits (297), Expect = 3e-26
Identities = 115/474 (24%), Positives = 213/474 (44%), Gaps = 70/474 (14%)
Query: 5 VQKFGGTSVGTLERIELCAKRVIKALEKGYKPVVVSSAMAGETDSLIELAKK-------- 56
V KFGG+SV + +R++ A ++ E+ +P+VV SAM T+ L+ +K
Sbjct: 87 VMKFGGSSVASADRMKEVATLILSFPEE--RPIVVLSAMGKTTNKLLLAGEKAVSCGVIN 144
Query: 57 ------------VHPRPPE-------------------------------REMDTLLAVG 73
+H R + R D L++ G
Sbjct: 145 VSSIEELCFIKDLHLRTVDQLGVDGSVISKHLEELEQLLKGIAMMKELTKRTQDYLVSFG 204
Query: 74 EQKAIALFAMTLNKLGYPAVSLCGWQVPIITDNVHTKARIRKI---GISRLL--SLIEEG 128
E + +FA LNK+G A +++ IT + T A I + +++ L + +
Sbjct: 205 ECMSTRIFAAYLNKIGVKARQYDAFEIGFITTDDFTNADILEATYPAVAKRLHGDWLSDP 264
Query: 129 YIPVVAGFQG-VTEDWEITTLGRGGSDTTXXXXXXXXXX-DCEINTDVPGVFTADPRIVP 186
I +V GF G + +TTLGRGGSD T + ++ DV GV T DP I P
Sbjct: 265 AIAIVTGFLGKARKSCAVTTLGRGGSDLTATTIGKALGLPEIQVWKDVDGVLTCDPNIYP 324
Query: 187 NAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEEGTWIVPEDEVM 246
A+ + ++++E ELA GA+V+ +S+ A + ++ + V+++++ + ++ + M
Sbjct: 325 KAEPVPYLTFDEAAELAYFGAQVLHPQSMRPARESDIPVRVKNSYNPKAPGTLITKARDM 384
Query: 247 EKVAVRGITVDTKETRFTV--VRVPDKPGIAAEIFKALGDAHIVVDMI-VQNVSHEGYTD 303
K + I + T + R+ + G A++F + I VD++ VS D
Sbjct: 385 SKAVLTSIVLKRNVTMLDIASTRMLGQYGFLAKVFSIFEELGISVDVVATSEVSVSLTLD 444
Query: 304 MSFTVNKTDADKAEEI--VKKIAQKIGAKEVVRDDKVAKISIVGIGMKSAYGVAGRMFDI 361
S ++ +A E+ V + +KI ++++ + IS++G +S+ + R+ +
Sbjct: 445 PSKLWSRELIQQASELDHVVEELEKIAVVNLLQNRSI--ISLIGNVQRSSL-ILERLSRV 501
Query: 362 LARNGINIKAIS--TSEIKISCLIDEKYAELAVRALHXXXXXXXXXXXTINGKN 413
L G+ ++ IS S++ IS ++++ AE VRALH ++ KN
Sbjct: 502 LRTLGVTVQMISQGASKVNISLVVNDSEAEQCVRALHSAFFESELSELEMDYKN 555
dbj|BAA07147.1| (D37928) aspartokinase beta-2 [Thermus aquaticus]
>gi|3088364|dbj|BAA25849.1| (AB013131) aspartate kinase
beta subunit [Thermus thermophilus]
Length = 161
Score = 120 bits (297), Expect = 3e-26
Identities = 63/149 (42%), Positives = 99/149 (66%), Gaps = 3/149 (2%)
Query: 250 AVRGITVDTKETRFTVVRVPDKPGIAAEIFKALGDAHIVVDMIVQNV-SHE-GYTDMSFT 307
AV G+ +D + ++ +PD+PGIAA++F+AL + I VDMI+Q V H+ M+FT
Sbjct: 6 AVTGVALDLDHAQIGLIGIPDQPGIAAKVFQALAERGIAVDMIIQGVPGHDPSRQQMAFT 65
Query: 308 VNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAKISIVGIGMKSAYGVAGRMFDILARNGI 367
V K A +A E ++ + +IG + ++R D +AK+SIVG+G+ S V +MF +A G
Sbjct: 66 VKKDFAQEALEALEPVLAEIGGEAILRPD-IAKVSIVGVGLASTPEVPAKMFQAVASTGA 124
Query: 368 NIKAISTSEIKISCLIDEKYAELAVRALH 396
NI+ I+TSE++IS +I +YAE A+RA+H
Sbjct: 125 NIEMIATSEVRISVIIPAEYAEAALRAVH 153
emb|CAA67376| (X98873) aspartate kinase [Arabidopsis thaliana]
Length = 569
Score = 116 bits (288), Expect = 3e-25
Identities = 113/457 (24%), Positives = 203/457 (43%), Gaps = 72/457 (15%)
Query: 5 VQKFGGTSVGTLERIELCAKRVIKALEKGYKPVVVSSAMAGETDSLI------------- 51
V KFGG+SV + ER++ A ++ E+ PV+V SAM T++L+
Sbjct: 89 VMKFGGSSVASAERMKEVADLILTFPEES--PVIVLSAMGKTTNNLLLAGEKAVSCGVSN 146
Query: 52 -------ELAKKVHPRPPE-------------------------------REMDTLLAVG 73
+ K++H R + R D L++ G
Sbjct: 147 ASEIEELSIIKELHIRTVKELNIDPSVILTYLEELEQLLKGIAMMKELTLRTRDYLVSFG 206
Query: 74 EQKAIALFAMTLNKLGYPAVSLCGWQVPIITDNVHTKARIRKIGISRLLSLIEEGY---- 129
E + +FA LN +G A +++ IT + T I + + + + +
Sbjct: 207 ECLSTRIFAAYLNTIGVKARQYDAFEIGFITTDDFTNGDILEATYPAVAKRLYDDWMHDP 266
Query: 130 -IPVVAGFQGVTEDWE---ITTLGRGGSDTTXXXXXXXXXX-DCEINTDVPGVFTADPRI 184
+P+V GF G + W+ +TTLGRGGSD T + ++ DV GV T DP I
Sbjct: 267 AVPIVTGFLG--KGWKTGAVTTLGRGGSDLTATTIGKALGLKEIQVWKDVDGVLTCDPTI 324
Query: 185 VPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEEGTWIVPEDE 244
A + ++++E ELA GA+V+ +S+ A + + + V+S+++ + I+ +
Sbjct: 325 YKRATPVPYLTFDEAAELAYFGAQVLHPQSMRPAREGEIPVRVKSSYNPKAPGTIITKTR 384
Query: 245 VMEKVAVRGITVDTKETRFTV--VRVPDKPGIAAEIFKALGDAHIVVDMI-VQNVSHEGY 301
M K + I + T + R+ + G A++F + I VD++ VS
Sbjct: 385 DMTKSILTSIVLKRNVTMLDIASTRMLGQVGFLAKVFSIFEELGISVDVVATSEVSISLT 444
Query: 302 TDMSFTVNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAKISIVGIGMKSAYGVAGRMFDI 361
D S ++ + + V + +KI +++ + IS++G S+ + R F +
Sbjct: 445 LDPSKLWSRELIQQELDHVVEELEKIAVVNLLKGRAI--ISLIGNVQHSSL-ILERAFHV 501
Query: 362 LARNGINIKAIS--TSEIKISCLIDEKYAELAVRALH 396
L G+N++ IS S++ IS +++E AE V+ALH
Sbjct: 502 LYTKGVNVQMISQGASKVNISFIVNEAEAEGCVQALH 538
dbj|BAA80125.1| (AP000060) 473aa long hypothetical aspartate kinase [Aeropyrum
pernix]
Length = 473
Score = 109 bits (269), Expect = 5e-23
Identities = 83/269 (30%), Positives = 122/269 (44%), Gaps = 59/269 (21%)
Query: 3 ILVQKFGGTSVGTLERIELCAKRVIKALEKGYKPVVVSSAMAGETDSLIELAKKVHP--- 59
++V KFGG+ + + V+ LE G +PVVV SA+ G TD+L+ ++ P
Sbjct: 27 LVVVKFGGSVLNGSPGFLAAGRLVLGLLESGLEPVVVVSAVKGVTDALLSSFERRDPGVG 86
Query: 60 ---------------RPPE---------------------------REMDTLLAVGEQKA 77
PPE R D +++ GE+ +
Sbjct: 87 GAVGKTYLSIARELGLPPESVRDVSLASAEVSKLLWAAEVLGQWTPRVRDLVVSYGERLS 146
Query: 78 IALFAMTLNKLGYPAVSLCGWQVPIITDNV---------HTKARIRKIGISRLLSLIEEG 128
AL A L +LG A L G + I+TD +T+ IR+ RL ++EEG
Sbjct: 147 AALMAGLLRRLGVEARWLGGGEAGIVTDGEFGDATPLYGYTEGVIRE----RLEPMLEEG 202
Query: 129 YIPVVAGFQGVTEDWEITTLGRGGSDTTXXXXXXXXXXD-CEINTDVPGVFTADPRIVPN 187
+PVVAGF G T + + T LGRGGSD T + TDVPG+ + DPR+V
Sbjct: 203 VVPVVAGFTGATREGDTTLLGRGGSDLTATLLASALGAGRVVLYTDVPGILSGDPRVVGE 262
Query: 188 AKKIKKISYEEMLELASLGAKVMQIRSVE 216
+++ +SYEE E+A LG + R+ E
Sbjct: 263 PRRVGYMSYEEAWEVARLGLRKFHPRTFE 291
emb|CAA18652.1| (AL022599) aspartate kinase [Schizosaccharomyces pombe]
Length = 519
Score = 106 bits (262), Expect = 4e-22
Identities = 86/294 (29%), Positives = 139/294 (47%), Gaps = 34/294 (11%)
Query: 130 IPVVAGFQGVTEDWEITTLGRGGSDTTXXXXXXXXXXD-CEINTDVPGVFTADPRIVPNA 188
+PVV GF G+ ++ +GRG +D D +I +V G+FTADPR VP A
Sbjct: 205 VPVVTGFFGMVPGGLLSQIGRGYTDFCAALLAVGLNADELQIWKEVDGIFTADPRKVPTA 264
Query: 189 KKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEE-EGTWIVPE----- 242
+ + I+ EE EL G++V+ ++ + I +++ + +GT I P+
Sbjct: 265 RLLPLITPEEAAELTYYGSEVIHPFTMSQVVHARIPIRIKNVGNPRGKGTVIFPDTISRH 324
Query: 243 -------------DEVMEKVAVRGITVDTKETRFTVVRVPDK-----PGIAAEIFKALGD 284
D++ +A +G T T + V+ + G A IF L
Sbjct: 325 GSATPPHPPKIMPDDISASLANKGATAVTIKDTIMVINIQSNRKISAHGFLASIFAILDK 384
Query: 285 AHIVVDMIVQNVSHEGYTDMSFTVNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAKISIV 344
+ VD+I + E + M+ D + E V+ +++G +++ +A +S+V
Sbjct: 385 YKLAVDLI---TTSEVHVSMALYEESDDGNMHEAFVE--LRRLGTLDILHG--LAILSLV 437
Query: 345 GIGMKSAYGVAGRMFDILARNGINIKAIS--TSEIKISCLIDEKYAELAVRALH 396
G M++ G AGRMF LA INI+ IS SEI ISC+IDEK A A+ +H
Sbjct: 438 GKHMRNTTGYAGRMFCKLAEAQINIEMISQGASEINISCVIDEKMAVKALNVIH 491
ref|NP_010972.1|HOM3| Aspartate kinase (L-aspartate 4-P-transferase) (EC 2.7.2.4); Hom3p
>gi|113559|sp|P10869|AK_YEAST ASPARTOKINASE (ASPARTATE
KINASE) >gi|66913|pir||KIBYD aspartate kinase (EC
2.7.2.4) - yeast (Saccharomyces cerevisiae) >gi|171693
(J03526) aspartokinase [Saccharomyces cerevisiae]
>gi|603285 (U18796) Hom3p: aspartate kinase
[Saccharomyces cerevisiae]
Length = 527
Score = 105 bits (259), Expect = 8e-22
Identities = 81/297 (27%), Positives = 141/297 (47%), Gaps = 31/297 (10%)
Query: 126 EEGYIPVVAGFQGVTEDWEITTLGRGGSDTTXXXXXXXXXXD-CEINTDVPGVFTADPRI 184
+E +PV GF G+ + +GRG +D D ++ +V G+FTADPR
Sbjct: 206 KERIVPVFTGFFGLVPTGLLNGVGRGYTDLCAALIAVAVNADELQVWKEVDGIFTADPRK 265
Query: 185 VPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEEGTWIVPEDE 244
VP A+ + ++ EE EL G++V+ ++E + + I +++ + I+ D
Sbjct: 266 VPEARLLDSVTPEEASELTYYGSEVIHPFTMEQVIRAKIPIRIKNVQNPLGNGTIIYPDN 325
Query: 245 VMEK------------------VAVRGITVDTKETRFTVVRVPDKP-----GIAAEIFKA 281
V +K RG T T + V+ + G A+IF
Sbjct: 326 VAKKGESTPPHPPENLSSSFYEKRKRGATAITTKNDIFVINIHSNKKTLSHGFLAQIFTI 385
Query: 282 LGDAHIVVDMIVQNVSHEGYTDMSFTVNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAKI 341
L +VVD+I + E + M+ + D+ K+ ++ + +G+ ++ + K++ +
Sbjct: 386 LDKYKLVVDLI---STSEVHVSMALPIPDADSLKSLRQAEEKLRILGSVDITK--KLSIV 440
Query: 342 SIVGIGMKSAYGVAGRMFDILARNGINIKAIS--TSEIKISCLIDEKYAELAVRALH 396
S+VG MK G+AG MF LA GINI+ IS +EI ISC+I+E + A++ +H
Sbjct: 441 SLVGKHMKQYIGIAGTMFTTLAEEGINIEMISQGANEINISCVINESDSIKALQCIH 497
sp|P08660|AK3_ECOLI LYSINE-SENSITIVE ASPARTOKINASE III (ASPARTATE KINASE III)
>gi|396359 (U00006) aspartokinase III [Escherichia coli]
>gi|1790455 (AE000475) aspartokinase III, lysine
sensitive [Escherichia coli]
Length = 449
Score = 103 bits (255), Expect = 2e-21
Identities = 112/452 (24%), Positives = 192/452 (41%), Gaps = 67/452 (14%)
Query: 2 KILVQKFGGTSVGTLERIELCAKRVIKALEKGYKPVVVSSAMAGETDSLIELAKKVHP-- 59
+I+V KFGGTSV + + A V L +VV SA AG T+ L+ LA+ + P
Sbjct: 3 EIVVSKFGGTSVADFDAMNRSADIV---LSDANVRLVVLSASAGITNLLVALAEGLEPGE 59
Query: 60 -------------------RPP-------EREMDTLLAVGEQKAIA-------------- 79
R P ER ++ + + E A+A
Sbjct: 60 RFEKLDAIRNIQFAILERLRYPNVIREEIERLLENITVLAEAAALATSPALTDELVSHGE 119
Query: 80 -----LFAMTLNKLGYPAVSLCGWQVPIITDNVHTK----ARIRKIGISRLLSLIEEGYI 130
LF L + A +V D A + ++ +LL + EG +
Sbjct: 120 LMSTLLFVEILRERDVQAQWFDVRKVMRTNDRFGRAEPDIAALAELAALQLLPRLNEGLV 179
Query: 131 PVVAGFQGVTEDWEITTLGRGGSDTTXXXXXXXXXXD-CEINTDVPGVFTADPRIVPNAK 189
+ GF G TTLGRGGSD T +I TDVPG++T DPR+V AK
Sbjct: 180 -ITQGFIGSENKGRTTTLGRGGSDYTAALLAEALHASRVDIWTDVPGIYTTDPRVVSAAK 238
Query: 190 KIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEEGTWIVPEDEVMEKV 249
+I +I++ E E+A+ GAKV+ ++ A + ++ + V S+ G +V ++
Sbjct: 239 RIDEIAFAEAAEMATFGAKVLHPATLLPAVRSDIPVFVGSSKDPRAGGTLVC-NKTENPP 297
Query: 250 AVRGITVDTKETRFTV--VRVPDKPGIAAEIFKALGDAHIVVDMIVQNVSHEGYTDMSFT 307
R + + +T T+ + + G AE+F L +I VD+I + ++ T
Sbjct: 298 LFRALALRRNQTLLTLHSLNMLHSRGFLAEVFGILARHNISVDLITTS-----EVSVALT 352
Query: 308 VNKTDADKAEE--IVKKIAQKIGAK-EVVRDDKVAKISIVGIGMKSAYGVAGRMFDILAR 364
++ T + + + + + ++ A V ++ +A ++++G + A GV +F +L
Sbjct: 353 LDTTGSTSTGDTLLTQSLLMELSALCRVEVEEGLALVALIGNDLSKACGVGKEVFGVLEP 412
Query: 365 NGINIKAISTSEIKISCLIDEKYAELAVRALH 396
I + S + L+ + AE V+ LH
Sbjct: 413 FNIRMICYGASSHNLCFLVPGEDAEQVVQKLH 444
Database: Non-redundant GenBank CDS
translations+PDB+SwissProt+SPupdate+PIR
Posted date: Jan 12, 2000 2:26 PM
Number of letters in database: 136,724,657
Number of sequences in database: 444,417
Lambda K H
0.317 0.135 0.375
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 96143962
Number of Sequences: 444417
Number of extensions: 3576974
Number of successful extensions: 10244
Number of sequences better than 10.0: 116
Number of HSP's better than 10.0 without gapping: 89
Number of HSP's successfully gapped in prelim test: 28
Number of HSP's that attempted gapping in prelim test: 9890
Number of HSP's gapped (non-prelim): 161
length of query: 415
length of database: 136,724,657
effective HSP length: 59
effective length of query: 356
effective length of database: 110,504,054
effective search space: 39339443224
effective search space used: 39339443224
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 71 (32.1 bits)
