Score E
Sequences producing significant alignments: (bits) Value
gi|2983614 (AE000726) S-adenosylmethionine synthetase [Aqui... 700 0.0
gb|AAD36725.1|AE001807_16 (AE001807) S-adenosylmethionine s... 382 e-105
sp|P54419|METK_BACSU S-ADENOSYLMETHIONINE SYNTHETASE (METHI... 377 e-104
gi|1389732 (U52812) S-adenosylmethionine synthetase [Bacill... 374 e-103
sp|P50307|METK_STAAU S-ADENOSYLMETHIONINE SYNTHETASE (METHI... 370 e-101
pdb|1XRA| Mol_id: 1; Molecule: S-Adenosylmethionine Synth... 367 e-101
sp|P04384|METK_ECOLI S-ADENOSYLMETHIONINE SYNTHETASE (METHI... 367 e-101
sp|P43762|METK_HAEIN S-ADENOSYLMETHIONINE SYNTHETASE (METHI... 362 3e-99
pdb|1XRB| S-Adenosylmethionine Synthetase (Mat, Atp: L-Me... 361 7e-99
gi|146851 (M98266) S-adenosylmethionine synthetase II [Esch... 358 6e-98
emb|CAB56090.1| (AJ238756) S-adenosylmethionine synthetase ... 357 1e-97
emb|CAB56109.1| (AJ238757) S-adenosylmethionine synthetase ... 352 3e-96
gb|AAD22464.1|AF117274_2 (AF117274) S-adenosylmethionine sy... 341 6e-93
gb|AAF10215.1|AE001921_7 (AE001921) S-adenosylmethionine sy... 336 2e-91
sp|P56460|METK_HELPY S-ADENOSYLMETHIONINE SYNTHETASE (METHI... 335 4e-91
sp|O83772|METK_TREPA S-ADENOSYLMETHIONINE SYNTHETASE (METHI... 333 1e-90
sp|Q9ZMN5|METK_HELPJ S-ADENOSYLMETHIONINE SYNTHETASE (METHI... 333 2e-90
ref|NP_005902.1|| methionine adenosyltransferase II, alpha ... 327 8e-89
sp|P72871|METK_SYNY3 S-ADENOSYLMETHIONINE SYNTHETASE (METHI... 325 4e-88
sp|P50306|METL_CAEEL PROBABLE S-ADENOSYLMETHIONINE SYNTHETA... 324 5e-88
sp|P18298|METK_RAT S-ADENOSYLMETHIONINE SYNTHETASE GAMMA FO... 324 7e-88
sp|O60198|METK_SCHPO S-ADENOSYLMETHIONINE SYNTHETASE (METHI... 324 9e-88
sp|P77899|METK_MYCTU S-ADENOSYLMETHIONINE SYNTHETASE (METHI... 323 2e-87
ref|NP_000420.1|| methionine adenosyltransferase I, alpha >... 320 1e-86
sp|O17680|METM_CAEEL PROBABLE S-ADENOSYLMETHIONINE SYNTHETA... 319 2e-86
pir||A47151 methionine adenosyltransferase (EC 2.5.1.6) - m... 319 2e-86
sp|P13444|METL_RAT S-ADENOSYLMETHIONINE SYNTHETASE ALPHA AN... 319 2e-86
sp|P50305|METK_CAEEL PROBABLE S-ADENOSYLMETHIONINE SYNTHETA... 318 4e-86
sp|P50304|METK_ASCIM S-ADENOSYLMETHIONINE SYNTHETASE (METHI... 318 4e-86
pir||S27363 methionine adenosyltransferase (EC 2.5.1.6) - h... 317 9e-86
sp|P48466|METK_NEUCR S-ADENOSYLMETHIONINE SYNTHETASE (METHI... 317 1e-85
gi|172534 (J03477) S-adenosylmethionine synthetase [Sacchar... 312 4e-84
ref|NP_013281.1|SAM1| S-adenosylmethionine synthetase; Sam1... 311 5e-84
ref|NP_010790.1|SAM2| S-adenosylmethionine synthetase; Sam2... 311 5e-84
sp|P40320|METK_DROME S-ADENOSYLMETHIONINE SYNTHETASE (METHI... 310 9e-84
pir||SYECSM methionine adenosyltransferase (EC 2.5.1.6) - E... 310 2e-83
gb|AAD55092.1|AF179714_1 (AF179714) S-adenosylmethionine sy... 309 3e-83
sp|O22338|METK_MUSAC S-ADENOSYLMETHIONINE SYNTHETASE (METHI... 308 6e-83
sp|P93254|METK_MESCR S-ADENOSYLMETHIONINE SYNTHETASE (METHI... 308 6e-83
sp|O43938|METK_LEIIN S-ADENOSYLMETHIONINE SYNTHETASE (METHI... 307 1e-82
sp|Q96552|METL_CATRO S-ADENOSYLMETHIONINE SYNTHETASE 2 (MET... 306 2e-82
sp|P46611|METK_ORYSA S-ADENOSYLMETHIONINE SYNTHETASE 1 (MET... 306 2e-82
sp|Q96551|METK_CATRO S-ADENOSYLMETHIONINE SYNTHETASE 1 (MET... 305 5e-82
sp|P50301|METK_ACTCH S-ADENOSYLMETHIONINE SYNTHETASE 1 (MET... 304 7e-82
sp|P47916|METK_POPDE S-ADENOSYLMETHIONINE SYNTHETASE (METHI... 303 1e-81
sp|P43281|METL_LYCES S-ADENOSYLMETHIONINE SYNTHETASE 2 (MET... 303 1e-81
gb|AAD48485.1|AF170798_1 (AF170798) S-adenosyl-L-methionine... 303 1e-81
sp|P50299|METK_HORVU S-ADENOSYLMETHIONINE SYNTHETASE 1 (MET... 302 4e-81
sp|P24260|METL_DIACA S-ADENOSYLMETHIONINE SYNTHETASE 2 (MET... 302 4e-81
sp|P93438|METL_ORYSA S-ADENOSYLMETHIONINE SYNTHETASE 2 (MET... 300 1e-80
sp|P43280|METK_LYCES S-ADENOSYLMETHIONINE SYNTHETASE 1 (MET... 300 1e-80
gi|1127583 (U36761) S-adenosylmethionine synthetase [Neuros... 300 1e-80
sp|Q27522|METN_CAEEL PROBABLE S-ADENOSYLMETHIONINE SYNTHETA... 300 2e-80
sp|P50302|METL_ACTCH S-ADENOSYLMETHIONINE SYNTHETASE 2 (MET... 300 2e-80
sp|Q96553|METM_CATRO S-ADENOSYLMETHIONINE SYNTHETASE 3 (MET... 298 4e-80
sp|P17562|METL_ARATH S-ADENOSYLMETHIONINE SYNTHETASE 2 (MET... 297 9e-80
gb|AAD56396.1|AF183891_1 (AF183891) S-adenosyl-L-methionine... 296 1e-79
pir||S66352 methionine adenosyltransferase (EC 2.5.1.6) 2 -... 295 3e-79
sp|P48498|METK_PETHY S-ADENOSYLMETHIONINE SYNTHETASE (METHI... 295 3e-79
sp|P43282|METM_LYCES S-ADENOSYLMETHIONINE SYNTHETASE 3 (MET... 295 3e-79
gb|AAD31573.1|AC006922_5 (AC006922) putative s-adenosylmeth... 295 4e-79
sp|P23686|METK_ARATH S-ADENOSYLMETHIONINE SYNTHETASE 1 (MET... 295 4e-79
sp|P49611|METK_BRAJU S-ADENOSYLMETHIONINE SYNTHETASE (METHI... 293 2e-78
sp|P50300|METK_PINBN S-ADENOSYLMETHIONINE SYNTHETASE (METHI... 292 4e-78
emb|CAB60317.1| (AL110479) Y105C5B.12 [Caenorhabditis elegans] 291 5e-78
sp|Q95032|METK_ACACA S-ADENOSYLMETHIONINE SYNTHETASE (METHI... 287 1e-76
sp|P49613|METL_PEA S-ADENOSYLMETHIONINE SYNTHETASE 2 (METHI... 286 2e-76
gi|2688287 (AE001143) S-adenosylmethionine synthetase (metK... 281 7e-75
sp|P50303|METM_ACTCH S-ADENOSYLMETHIONINE SYNTHETASE 3 (MET... 272 3e-72
sp|P78003|METK_MYCPN S-ADENOSYLMETHIONINE SYNTHETASE (METHI... 259 2e-68
sp|P49612|METK_PEA S-ADENOSYLMETHIONINE SYNTHETASE 1 (METHI... 256 3e-67
gi|609557 (L36680) S-adenosylmethionine synthase [Pisum sat... 244 8e-64
sp|P47293|METK_MYCGE S-ADENOSYLMETHIONINE SYNTHETASE (METHI... 232 4e-60
pir||S51671 methionine adenosyltransferase (EC 2.5.1.6) - A... 225 6e-58
sp|O09486|METK_AMOPR S-ADENOSYLMETHIONINE SYNTHETASE (METHI... 190 2e-47
gb|AAD32557.1|AF121191_1 (AF121191) truncated S-adenosylmet... 178 5e-44
sp|P31155|METK_PETCR S-ADENOSYLMETHIONINE SYNTHETASE 1 (MET... 175 6e-43
gi|2454484 (AF008568) S-adenosylmethionine synthetase [Chla... 157 1e-37
gi|863000 (U27348) S-adenosyl-L-methionine synthetase [Popu... 145 5e-34
gb|AAD39635.1|AF139181_1 (AF139181) S-adenosylmethionine sy... 139 3e-32
sp|P31156|METL_PETCR S-ADENOSYLMETHIONINE SYNTHETASE 2 (MET... 129 4e-29
dbj|BAA21726| (AB006187) S-adenosylmethionine synthase [Nic... 109 3e-23
gi|1350480 (L78303) S-adenosylmethinine synthetase [Aeromon... 102 6e-21
emb|CAA65455| (X96680) methionine adenosyltransferase [Cath... 86 4e-16
pir||S53116 SAM-synthetase - chickpea (fragment) >gi|732576... 78 1e-13
emb|CAA83822| (Z33281) S-adenosyl-Met synthetase 2 [Mycopla... 69 4e-11
emb|CAA05399| (AJ002415) S-adenosylmethionine synthetase [C... 66 4e-10
gi|409888 (U02123) Homology to S-adenosylmethionine synthet... 62 6e-09
gi|147855 (M31770) methionine adenosyltransferase (metK) [E... 57 2e-07
dbj|BAA08531| (D49655) S-adenosyl-L-methionin synthetase [H... 45 0.001
gb|AAD35357.1|AE001709_3 (AE001709) 5-methyltetrahydrofolat... 38 0.18
sp|P17422|CLPB_BACNO CLPB PROTEIN >gi|97341|pir||C35905 ATP... 33 3.6
gi|145053 (M32229) ATP-dependent protease [Dichelobacter no... 33 3.6
gi|3420122 (AF019298) submaxillary mucin [Bos taurus] 32 8.0
gi|2983614 (AE000726) S-adenosylmethionine synthetase [Aquifex aeolicus]
Length = 376
Score = 700 bits (1786), Expect = 0.0
Identities = 349/362 (96%), Positives = 349/362 (96%)
Query: 1 MYNLRMAESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTES 60
MYNLRMAESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTES
Sbjct: 1 MYNLRMAESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTES 60
Query: 61 YVDIPRVVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSEGAGDTAIVVGY 120
YVDIPRVVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSEGAGDTAIVVGY
Sbjct: 61 YVDIPRVVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSEGAGDTAIVVGY 120
Query: 121 ATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYEDGKPSYVQSIVA 180
ATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYEDGKPSYVQSIVA
Sbjct: 121 ATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYEDGKPSYVQSIVA 180
Query: 181 YVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADTGLTGRK 240
YVHHDPDVSINHLREL FLTEKTSIKVNPTGRFVIGGPVADTGLTGRK
Sbjct: 181 YVHHDPDVSINHLRELIIEEIIKKEIPEEFLTEKTSIKVNPTGRFVIGGPVADTGLTGRK 240
Query: 241 IVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIGYAFGLT 300
IVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIGYAFGLT
Sbjct: 241 IVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIGYAFGLT 300
Query: 301 EPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKPIYRQTSVYGHFGKENL 360
EPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKPIYRQTSVYGHFGKENL
Sbjct: 301 EPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKPIYRQTSVYGHFGKENL 360
Query: 361 PW 362
PW
Sbjct: 361 PW 362
gb|AAD36725.1|AE001807_16 (AE001807) S-adenosylmethionine synthetase [Thermotoga maritima]
Length = 395
Score = 382 bits (971), Expect = e-105
Identities = 190/380 (50%), Positives = 252/380 (66%), Gaps = 18/380 (4%)
Query: 1 MYNLRMAESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTES 60
M L +ESVTEGHPDKIADQ++DA+LD +++DP S+V++E +VTTGLV++ GE+TT +
Sbjct: 1 MRRLFTSESVTEGHPDKIADQISDAILDAMLEQDPRSRVAVETLVTTGLVIIAGEVTTRA 60
Query: 61 YVDIPRVVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE----------- 109
YV+IP + R I +IGYTR + GFD +TC V+ SI QSP+IALG+
Sbjct: 61 YVEIPDIARKTILEIGYTRAKYGFDGETCGVLTSIHSQSPDIALGVDKALEVKTGEEVAD 120
Query: 110 -----GAGDTAIVVGYATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVA 164
GAGD I+ GYAT E P MP PIT+AHK+ R++E RK G PFLRPDGK V
Sbjct: 121 EFEALGAGDQGIMFGYATNETPEYMPLPITLAHKLAMRLAEVRKNGTLPFLRPDGKTQVT 180
Query: 165 MIYEDGKPSYVQSIVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGR 224
+ YED KP V +++ HDPD+S LRE + +K I VNPTGR
Sbjct: 181 IEYEDDKPVRVDTVLISTQHDPDISQADLREAIIEHVINPVIPEQYRDDKMKILVNPTGR 240
Query: 225 FVIGGPVADTGLTGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGG 284
FV+GGP+ADTGLTGRKI+ D YG GG AFSGKDPTK DRS Y+AR +AK+VVA G
Sbjct: 241 FVLGGPMADTGLTGRKIIVDTYGGWVPHGGGAFSGKDPTKVDRSAHYMARYVAKNVVAAG 300
Query: 285 WAERCLVQIGYAFGLTEPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKP 344
A++ L+Q+ YA G+ +PV+ I+T+GT K+ ++ L + ++F RP II+ L+L +P
Sbjct: 301 LADKFLIQLSYAIGVAKPVSIMIDTYGTAKVDEDKLLKVITELFDFRPGAIIKKLNLLRP 360
Query: 345 IYRQTSVYGHFGK--ENLPW 362
IYR+T+ YGHFG+ E W
Sbjct: 361 IYRKTAAYGHFGRNEEEFTW 380
sp|P54419|METK_BACSU S-ADENOSYLMETHIONINE SYNTHETASE (METHIONINE ADENOSYLTRANSFERASE)
(ADOMET SYNTHETASE) >gi|2293164 (AF008220) SAM synthase
[Bacillus subtilis] >gi|2635539|emb|CAB15033| (Z99119)
S-adenosylmethionine synthetase [Bacillus subtilis]
Length = 400
Score = 377 bits (958), Expect = e-104
Identities = 188/375 (50%), Positives = 249/375 (66%), Gaps = 19/375 (5%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESVTEGHPDKI DQ++D++LDE +KKDP ++V+ E VTTGLV+V GE+TT +YVDIP+
Sbjct: 10 SESVTEGHPDKICDQISDSILDEILKKDPNARVACETSVTTGLVLVSGEITTSTYVDIPK 69
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE----------------G 110
VR IK+IGYTR + GFDA+TCAV+ SIDEQS +IA+G+ G
Sbjct: 70 TVRQTIKEIGYTRAKYGFDAETCAVLTSIDEQSADIAMGVDQALEAREGTMSDEEIEAIG 129
Query: 111 AGDTAIVVGYATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIY-ED 169
AGD ++ GYA E LMP PI++AHK+ +R+SE RK P+LRPDGK V + Y E+
Sbjct: 130 AGDQGLMFGYACNETKELMPLPISLAHKLARRLSEVRKEDILPYLRPDGKTQVTVEYDEN 189
Query: 170 GKPSYVQSIVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGG 229
KP + +IV H P++++ ++ + E+T +NPTGRFVIGG
Sbjct: 190 NKPVRIDAIVISTQHHPEITLEQIQRNIKEHVINPVVPEELIDEETKYFINPTGRFVIGG 249
Query: 230 PVADTGLTGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERC 289
P D GLTGRKI+ D YG GG AFSGKD TK DRS +Y AR +AK++VA A+ C
Sbjct: 250 PQGDAGLTGRKIIVDTYGGYARHGGGAFSGKDATKVDRSAAYAARYVAKNIVAAELADSC 309
Query: 290 LVQIGYAFGLTEPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKPIYRQT 349
VQ+ YA G+ +PV+ I TFG+ K S+E L + V+ F LRPA II+ LDLR+PIY+QT
Sbjct: 310 EVQLAYAIGVAQPVSISINTFGSGKASEEKLIEVVRNNFDLRPAGIIKMLDLRRPIYKQT 369
Query: 350 SVYGHFGKE--NLPW 362
+ YGHFG+ +LPW
Sbjct: 370 AAYGHFGRHDVDLPW 384
gi|1389732 (U52812) S-adenosylmethionine synthetase [Bacillus subtilis]
Length = 400
Score = 374 bits (951), Expect = e-103
Identities = 188/375 (50%), Positives = 248/375 (66%), Gaps = 19/375 (5%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESVTEGHPDKI DQ+ D++LDE +KKDP ++V+ E VTTGLV+V GE+TT +YVDIP+
Sbjct: 10 SESVTEGHPDKICDQIYDSILDEILKKDPNARVACETSVTTGLVLVSGEITTSTYVDIPK 69
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALG----------------ISSEG 110
VR IK+IGYTR + GFDA+TCAV+ SIDEQS +IA+G I + G
Sbjct: 70 TVRQTIKEIGYTRAKYGFDAETCAVLTSIDEQSADIAMGVDPALEAREGTMSDEEIEAIG 129
Query: 111 AGDTAIVVGYATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIY-ED 169
AGD ++ GY E LMP PI++AHK+ +R+SE RK P+LRPDGK V + Y E+
Sbjct: 130 AGDQGLMFGYVCNETKELMPLPISLAHKLARRLSEVRKEDILPYLRPDGKTQVTVEYDEN 189
Query: 170 GKPSYVQSIVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGG 229
KP + +IV H P++++ ++ + E+T +NPTGRFVIGG
Sbjct: 190 NKPVRIDAIVISTQHHPEITLEQIQRNIKEHVINPVVPEELIDEETKYFINPTGRFVIGG 249
Query: 230 PVADTGLTGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERC 289
P D GLTGRKI+ D YG GG AFSGKD TK DRS +Y AR +AK++VA A+ C
Sbjct: 250 PQGDAGLTGRKIIVDTYGGYARHGGGAFSGKDATKVDRSAAYAARYVAKNIVAAELADSC 309
Query: 290 LVQIGYAFGLTEPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKPIYRQT 349
VQ+ YA G+ +PV+ I TFG+ K S+E L + V+ F LRPA II+ LDLR+PIY+QT
Sbjct: 310 EVQLAYAIGVAQPVSISINTFGSGKASEEKLIEVVRNNFDLRPAGIIKMLDLRRPIYKQT 369
Query: 350 SVYGHFGKE--NLPW 362
+ YGHFG+ +LPW
Sbjct: 370 AAYGHFGRHDVDLPW 384
sp|P50307|METK_STAAU S-ADENOSYLMETHIONINE SYNTHETASE (METHIONINE ADENOSYLTRANSFERASE)
(ADOMET SYNTHETASE) >gi|1020317 (U36379)
S-adenosylmethionine synthetase [Staphylococcus aureus]
Length = 397
Score = 370 bits (940), Expect = e-101
Identities = 184/374 (49%), Positives = 251/374 (66%), Gaps = 18/374 (4%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESVTEGHPDKIADQ++DA+LD +K DP ++V+ E VTTG+ ++ GE++T +YVDIP+
Sbjct: 10 SESVTEGHPDKIADQVSDAILDAILKDDPNARVACETTVTTGMALIAGEISTTTYVDIPK 69
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALG---------------ISSEGA 111
VVR IK+IGYTR + G+D +T A++ +IDEQSP+IA G I + GA
Sbjct: 70 VVRETIKEIGYTRAKYGYDYETMAILTAIDEQSPDIAQGVDKALEYRDKDSEEEIEATGA 129
Query: 112 GDTAIVVGYATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIY-EDG 170
GD ++ GYAT E MP I ++H++ KR+S+ RK G +LRPDGKV V + Y E+
Sbjct: 130 GDQGLMFGYATNETETYMPLAIYLSHQLAKRLSDVRKDGTLNYLRPDGKVQVTVEYDEND 189
Query: 171 KPSYVQSIVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGP 230
P + +IV H DV++ ++E + E+T +NPTGRFVIGGP
Sbjct: 190 NPVRIDTIVVSTQHAEDVTLEQIQEDIKAHVIYPTVPENLINEQTKFYINPTGRFVIGGP 249
Query: 231 VADTGLTGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCL 290
D GLTGRKI+ D YG I GG FSGKDPTK DRS +Y AR +AK++VA G A++C
Sbjct: 250 QGDAGLTGRKIIVDTYGGIARHGGGCFSGKDPTKVDRSAAYAARYVAKNIVAAGLADQCE 309
Query: 291 VQIGYAFGLTEPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKPIYRQTS 350
VQ+ YA G+ EPV+ I+TFGT K+S+ L +AV+K F LRPA II+ LDL++PIY+QT+
Sbjct: 310 VQLAYAIGVAEPVSIAIDTFGTGKVSEGQLVEAVRKHFDLRPAGIIKMLDLKQPIYKQTA 369
Query: 351 VYGHFGKENL--PW 362
YGHFG+ ++ PW
Sbjct: 370 AYGHFGRTDVLFPW 383
pdb|1XRA| Mol_id: 1; Molecule: S-Adenosylmethionine Synthetase; Chain: Null;
Synonym: Mat, Atp:l-Methionine S-Adenosyltransferase;
Ec: 2.5.1.6; Biological_unit: Homotetramer
>gi|1421290|pdb|1XRC| Mol_id: 1; Molecule:
S-Adenosylmethionine Synthetase; Chain: Null; Synonym:
Mat, Atp:l-Methionine S-Adenosyltransferase; Ec:
2.5.1.6; Other_details: Crystallized With Two Co Ions
Instead Of Mg Ions; Biological_unit: Homotetramer
>gi|1633158|pdb|1MXC| S-Adenosylmethionine Synthetase
With 8-Br-Adp >gi|1633159|pdb|1MXB|
S-Adenosylmethionine Synthetase With Adp
>gi|1633160|pdb|1MXA| S-Adenosylmethionine Synthetase
With Ppi >gi|1827907|pdb|1FUG|A Chain A,
S-Adenosylmethionine Synthetase >gi|1827908|pdb|1FUG|B
Chain B, S-Adenosylmethionine Synthetase
Length = 383
Score = 367 bits (933), Expect = e-101
Identities = 174/365 (47%), Positives = 246/365 (66%), Gaps = 5/365 (1%)
Query: 3 NLRMAESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYV 62
+L +ESV+EGHPDKIADQ++DA+LD +++DP ++V+ E V TG+V+VGGE+TT ++V
Sbjct: 3 HLFTSESVSEGHPDKIADQISDAVLDAILEQDPKARVACETYVKTGMVLVGGEITTSAWV 62
Query: 63 DIPRVVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGIS-----SEGAGDTAIV 117
DI + R+ +++IGY ++GFDA++CAV+ +I +QSP+I G+ +GAGD ++
Sbjct: 63 DIEEITRNTVREIGYVHSDMGFDANSCAVLSAIGKQSPDINQGVDRADPLEQGAGDQGLM 122
Query: 118 VGYATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYEDGKPSYVQS 177
GYAT E LMP PIT AH++ +R +E RK G P+LRPD K V Y+DGK + +
Sbjct: 123 FGYATNETDVLMPAPITYAHRLVQRQAEVRKNGTLPWLRPDAKSQVTFQYDDGKIVGIDA 182
Query: 178 IVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADTGLT 237
+V H ++ L+E +LT T +NPTGRFVIGGP+ D GLT
Sbjct: 183 VVLSTQHSEEIDQKSLQEAVMEEIIKPILPAEWLTSATKFFINPTGRFVIGGPMGDCGLT 242
Query: 238 GRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIGYAF 297
GRKI+ D YG + GG AFSGKDP+K DRS +Y AR +AK++VA G A+RC +Q+ YA
Sbjct: 243 GRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGLADRCEIQVSYAI 302
Query: 298 GLTEPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKPIYRQTSVYGHFGK 357
G+ EP + +ETFGTEK+ E L V++ F LRP +I+ LDL PIY++T+ YGHFG+
Sbjct: 303 GVAEPTSIMVETFGTEKVPSEQLTLLVREFFDLRPYGLIQMLDLLHPIYKETAAYGHFGR 362
Query: 358 ENLPW 362
E+ PW
Sbjct: 363 EHFPW 367
sp|P04384|METK_ECOLI S-ADENOSYLMETHIONINE SYNTHETASE (METHIONINE ADENOSYLTRANSFERASE)
(ADOMET SYNTHETASE) >gi|882471 (U28377) CG Site No. 507
[Escherichia coli] >gi|1789311 (AE000377) methionine
adenosyltransferase 1 (AdoMet synthetase); methyl and
propylamine donor, corepressor of met genes [Escherichia
coli]
Length = 384
Score = 367 bits (933), Expect = e-101
Identities = 174/365 (47%), Positives = 246/365 (66%), Gaps = 5/365 (1%)
Query: 3 NLRMAESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYV 62
+L +ESV+EGHPDKIADQ++DA+LD +++DP ++V+ E V TG+V+VGGE+TT ++V
Sbjct: 4 HLFTSESVSEGHPDKIADQISDAVLDAILEQDPKARVACETYVKTGMVLVGGEITTSAWV 63
Query: 63 DIPRVVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGIS-----SEGAGDTAIV 117
DI + R+ +++IGY ++GFDA++CAV+ +I +QSP+I G+ +GAGD ++
Sbjct: 64 DIEEITRNTVREIGYVHSDMGFDANSCAVLSAIGKQSPDINQGVDRADPLEQGAGDQGLM 123
Query: 118 VGYATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYEDGKPSYVQS 177
GYAT E LMP PIT AH++ +R +E RK G P+LRPD K V Y+DGK + +
Sbjct: 124 FGYATNETDVLMPAPITYAHRLVQRQAEVRKNGTLPWLRPDAKSQVTFQYDDGKIVGIDA 183
Query: 178 IVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADTGLT 237
+V H ++ L+E +LT T +NPTGRFVIGGP+ D GLT
Sbjct: 184 VVLSTQHSEEIDQKSLQEAVMEEIIKPILPAEWLTSATKFFINPTGRFVIGGPMGDCGLT 243
Query: 238 GRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIGYAF 297
GRKI+ D YG + GG AFSGKDP+K DRS +Y AR +AK++VA G A+RC +Q+ YA
Sbjct: 244 GRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGLADRCEIQVSYAI 303
Query: 298 GLTEPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKPIYRQTSVYGHFGK 357
G+ EP + +ETFGTEK+ E L V++ F LRP +I+ LDL PIY++T+ YGHFG+
Sbjct: 304 GVAEPTSIMVETFGTEKVPSEQLTLLVREFFDLRPYGLIQMLDLLHPIYKETAAYGHFGR 363
Query: 358 ENLPW 362
E+ PW
Sbjct: 364 EHFPW 368
sp|P43762|METK_HAEIN S-ADENOSYLMETHIONINE SYNTHETASE (METHIONINE ADENOSYLTRANSFERASE)
(ADOMET SYNTHETASE) >gi|1075293|pir||H64187
S-adenosylmethionine synthetase 2 (metX) homolog -
Haemophilus influenzae (strain Rd KW20) >gi|1574099
(U32797) S-adenosylmethionine synthetase (metX)
[Haemophilus influenzae Rd]
Length = 384
Score = 362 bits (919), Expect = 3e-99
Identities = 178/361 (49%), Positives = 241/361 (66%), Gaps = 5/361 (1%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESV+EGHPDKIADQ++DA+LDE +K+DP ++V+ E V TG+ +VGGE+TT ++VDI
Sbjct: 8 SESVSEGHPDKIADQISDAVLDEILKQDPKARVACETYVKTGMALVGGEITTSAWVDIEN 67
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE-----GAGDTAIVVGYA 121
+ R VI DIGY E+GFD +CAV+ +I +QS +I G+ E GAGD I+ GYA
Sbjct: 68 LTRKVICDIGYEHSEMGFDGHSCAVLNAIGKQSADINQGVDRENPLDQGAGDQGIMFGYA 127
Query: 122 TKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYEDGKPSYVQSIVAY 181
T E LMP IT AH++ ++ SE RK GK +LRPD K V + YED K V ++V
Sbjct: 128 TNETDVLMPAAITYAHRLMEKQSEVRKSGKLAWLRPDAKSQVTLKYEDNKIVGVDAVVLS 187
Query: 182 VHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADTGLTGRKI 241
H +VS L E +L+++T +NPTGRFVIGGP+ D GLTGRKI
Sbjct: 188 TQHSEEVSQKDLHEGVMEEIIKPVLPSEWLSKETKFFINPTGRFVIGGPMGDCGLTGRKI 247
Query: 242 VSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIGYAFGLTE 301
+ D YG GG AFSGK+P+K DRS +Y AR +AK++VA G A+RC +Q+ YA G+ E
Sbjct: 248 IVDTYGGAARHGGGAFSGKEPSKVDRSAAYAARYVAKNIVAAGLADRCEIQLSYAIGVAE 307
Query: 302 PVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKPIYRQTSVYGHFGKENLP 361
P + +ETFGT K++ E+L V++ F LRP +I+ LDL +PIYR+T+ YGHFG+E P
Sbjct: 308 PTSIMVETFGTGKVANELLVSLVREFFDLRPYGLIKMLDLIQPIYRETAAYGHFGREQFP 367
Query: 362 W 362
W
Sbjct: 368 W 368
pdb|1XRB| S-Adenosylmethionine Synthetase (Mat, Atp: L-Methionine
S-Adenosyltransferase, E.C.2.5.1.6) In Which Met
Residues Are Replaced With Selenomethionine Residues
(Mse)
Length = 383
Score = 361 bits (916), Expect = 7e-99
Identities = 174/365 (47%), Positives = 241/365 (65%), Gaps = 5/365 (1%)
Query: 3 NLRMAESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYV 62
+L +ESV+EGHPDKIADQ++DA+LD +++DP ++V+ E V TG V+VGGE+TT ++V
Sbjct: 3 HLFTSESVSEGHPDKIADQISDAVLDAILEQDPKARVACETYVKTGXVLVGGEITTSAWV 62
Query: 63 DIPRVVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGIS-----SEGAGDTAIV 117
DI + R+ +++IGY + GFDA++CAV+ +I +QSP+I G+ +GAGD +
Sbjct: 63 DIEEITRNTVREIGYVHSDXGFDANSCAVLSAIGKQSPDINQGVDRADPLEQGAGDQGLX 122
Query: 118 VGYATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYEDGKPSYVQS 177
GYAT E L P PIT AH++ +R +E RK G P+LRPD K V Y+DGK + +
Sbjct: 123 FGYATNETDVLXPAPITYAHRLVQRQAEVRKNGTLPWLRPDAKSQVTFQYDDGKIVGIDA 182
Query: 178 IVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADTGLT 237
+V H ++ L+E +LT T +NPTGRFVIGGP D GLT
Sbjct: 183 VVLSTQHSEEIDQKSLQEAVXEEIIKPILPAEWLTSATKFFINPTGRFVIGGPXGDCGLT 242
Query: 238 GRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIGYAF 297
GRKI+ D YG GG AFSGKDP+K DRS +Y AR +AK++VA G A+RC +Q+ YA
Sbjct: 243 GRKIIVDTYGGXARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGLADRCEIQVSYAI 302
Query: 298 GLTEPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKPIYRQTSVYGHFGK 357
G+ EP + +ETFGTEK+ E L V++ F LRP +I+ LDL PIY++T+ YGHFG+
Sbjct: 303 GVAEPTSIXVETFGTEKVPSEQLTLLVREFFDLRPYGLIQXLDLLHPIYKETAAYGHFGR 362
Query: 358 ENLPW 362
E+ PW
Sbjct: 363 EHFPW 367
gi|146851 (M98266) S-adenosylmethionine synthetase II [Escherichia coli]
Length = 383
Score = 358 bits (908), Expect = 6e-98
Identities = 172/365 (47%), Positives = 244/365 (66%), Gaps = 6/365 (1%)
Query: 3 NLRMAESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYV 62
+L +ESV+EGHPDKIADQ++DA+LD +++DP ++V+ E V TG+V+VGGE+TT ++V
Sbjct: 4 HLFTSESVSEGHPDKIADQISDAVLDAILEQDPKARVACETYVKTGMVLVGGEITTSAWV 63
Query: 63 DIPRVVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGIS-----SEGAGDTAIV 117
DI + R+ +++IGY ++GFDA++CAV+ +I +QSP+I G+ +GAGD ++
Sbjct: 64 DIEEITRNTVREIGYVHSDMGFDANSCAVLSAIGKQSPDINQGVDRADPLEQGAGDQGLM 123
Query: 118 VGYATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYEDGKPSYVQS 177
GYAT E LMP PIT AH++ +R +E RK G +RPD K V Y+DGK + +
Sbjct: 124 FGYATNETDVLMPAPITYAHRLVQRQAEVRKNGTLR-VRPDAKSQVTFQYDDGKIVGIDA 182
Query: 178 IVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADTGLT 237
+V H ++ L+E +LT T +NPTGRFVIGGP+ D GLT
Sbjct: 183 VVLSTQHSEEIDQKSLQEAVMEEIIKPILPAEWLTSATKFFINPTGRFVIGGPMGDCGLT 242
Query: 238 GRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIGYAF 297
GRKI+ D YG + GG AFSGKDP+K DRS +Y AR +AK++VA G A+RC +Q+ YA
Sbjct: 243 GRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGLADRCEIQVSYAI 302
Query: 298 GLTEPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKPIYRQTSVYGHFGK 357
G+ EP + +ETFGTEK+ E L V++ F LRP +I+ LDL PIY++T+ YGHFG+
Sbjct: 303 GVAEPTSIMVETFGTEKVPSEQLTLLVREFFDLRPYGLIQMLDLLHPIYKETAAYGHFGR 362
Query: 358 ENLPW 362
E+ PW
Sbjct: 363 EHFPW 367
emb|CAB56090.1| (AJ238756) S-adenosylmethionine synthetase [Rickettsia prowazekii]
Length = 380
Score = 357 bits (906), Expect = 1e-97
Identities = 181/363 (49%), Positives = 236/363 (64%), Gaps = 7/363 (1%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESV+EGHPDKIADQ++DA+LDE +K DP +V+ E VTTGLV+VGGE+TT +YVDI +
Sbjct: 8 SESVSEGHPDKIADQISDAVLDEILKHDPNGRVACETFVTTGLVLVGGEITTNTYVDIEQ 67
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE-----GAGDTAIVVGYA 121
VVR+ I++IGY P GFD CAV+ SI +QSP+IA+GI +E GAGD +V GYA
Sbjct: 68 VVRNKIQEIGYNNPNYGFDGSCCAVISSIIKQSPDIAMGIDNENEEEIGAGDQGMVFGYA 127
Query: 122 TKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYEDGKPSYVQSIVAY 181
E +LMP PI AH + KR + RK +LRPD K V + YE+ KP + S+V
Sbjct: 128 CNETKSLMPAPIYYAHLLMKRQAYLRKQNILSWLRPDAKSQVTLRYENNKPIVIDSVVLS 187
Query: 182 VHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADTGLTGRKI 241
H P++ L E L + T +NPTGRFVIGGPVAD GLTGRKI
Sbjct: 188 TQHHPEIQQKDLIEAVIEEIIKPTLPTNLLHKDTKYLINPTGRFVIGGPVADCGLTGRKI 247
Query: 242 VSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIGYAFGLTE 301
+ D+YG + GG FSGKDPTK DRS +Y+AR IAK++V G A+RC +QI YA G+ +
Sbjct: 248 IVDSYGGMAKHGGGCFSGKDPTKIDRSAAYMARYIAKNIVGAGLADRCEIQISYAIGVAD 307
Query: 302 PVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKPIYRQTSVYGHFGK--EN 359
PV+ ETFGT K+S E + + F +RP +II+ L L Y++T+ YGHFG+ EN
Sbjct: 308 PVSVYAETFGTSKLSNEQTTKLITEHFDMRPGKIIKNLKLHTQCYQKTATYGHFGREDEN 367
Query: 360 LPW 362
W
Sbjct: 368 FTW 370
emb|CAB56109.1| (AJ238757) S-adenosylmethionine synthetase [Rickettsia typhi]
Length = 382
Score = 352 bits (894), Expect = 3e-96
Identities = 180/363 (49%), Positives = 233/363 (63%), Gaps = 7/363 (1%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESV+EGHPDKIADQ++DA+LDE +K DP +V+ E VTTGLV+VGGE+TT +YVDI +
Sbjct: 8 SESVSEGHPDKIADQISDAVLDEILKHDPNGRVACETFVTTGLVLVGGEITTNTYVDIEQ 67
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE-----GAGDTAIVVGYA 121
VVR+ I +IGY P GFD CAV+ SI +QSP+IA+GI + GAGD +V GYA
Sbjct: 68 VVRNKIHEIGYNNPSYGFDGSCCAVISSIVKQSPDIAMGIDNANEEEIGAGDQGMVFGYA 127
Query: 122 TKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYEDGKPSYVQSIVAY 181
E +LMP PI AH + KR + RK +LRPD K V + YE+ KP + S+V
Sbjct: 128 CNETKSLMPAPIYYAHLLMKRQAYLRKQNILSWLRPDAKSQVTLRYENNKPIVIDSVVLS 187
Query: 182 VHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADTGLTGRKI 241
H P++ L E L + T +NPTGRFVIGGPVAD GLTGRKI
Sbjct: 188 TQHHPEIQQKDLIEAVIEEIIKPTLPTHLLHKDTKYLINPTGRFVIGGPVADCGLTGRKI 247
Query: 242 VSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIGYAFGLTE 301
+ D+YG + GG FSGKDPTK DRS +Y+AR IAK++V G A+RC +QI YA G+
Sbjct: 248 IVDSYGGMAKHGGGCFSGKDPTKIDRSAAYMARYIAKNIVGSGLADRCEIQISYAIGVAS 307
Query: 302 PVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKPIYRQTSVYGHFGK--EN 359
PV+ ETFGT K+S E + + F +RP +II+ L L Y++T+ YGHFG+ EN
Sbjct: 308 PVSVYAETFGTSKLSNEQTTKLITEHFDMRPGKIIKNLKLHTQCYQKTASYGHFGREDEN 367
Query: 360 LPW 362
W
Sbjct: 368 FTW 370
gb|AAD22464.1|AF117274_2 (AF117274) S-adenosylmethionine synthetase [Streptomyces
spectabilis]
Length = 411
Score = 341 bits (865), Expect = 6e-93
Identities = 176/373 (47%), Positives = 233/373 (62%), Gaps = 22/373 (5%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESVTEGHPDKIADQ++D +LD +++DP S+V++E ++TTGLV V GE+TT++Y I +
Sbjct: 8 SESVTEGHPDKIADQISDTILDALLREDPTSRVAVETLITTGLVHVAGEVTTKAYAPIAQ 67
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISS---------------EGA 111
+VR I +IGY + GFD +C V SI QSP+IA G+ + +GA
Sbjct: 68 LVREKILEIGYDSSKKGFDGASCGVSVSIGAQSPDIAQGVDTAYESRVEGDEDELDRQGA 127
Query: 112 GDTAIVVGYATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYEDGK 171
GD ++ GYA E P LMP PI +AH++++R+SE RK G P+LRPDGK V + Y+ K
Sbjct: 128 GDQGLMFGYACDETPELMPLPIHLAHRLSRRLSEVRKNGTIPYLRPDGKTQVTIEYDGDK 187
Query: 172 PSYVQSIVAYVHHDPDVSINHL-----RELXXXXXXXXXXXXXFL--TEKTSIKVNPTGR 224
+ ++V H D+ + L RE TE + VNPTGR
Sbjct: 188 AVRLDTVVVSSQHASDIDLESLLAPDIREFVVEPELKALVEDGIKLETEGYRLLVNPTGR 247
Query: 225 FVIGGPVADTGLTGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGG 284
F IGGP+ D GLTGRKI+ D YG + GG AFSGKDP+K DRS +Y R +AK+VVA G
Sbjct: 248 FEIGGPMGDAGLTGRKIIIDTYGGMSRHGGGAFSGKDPSKVDRSAAYAMRWVAKNVVAAG 307
Query: 285 WAERCLVQIGYAFGLTEPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKP 344
A RC VQ+ YA G EPV +ETFGT I + +E A+ +VF LRPA II LDL +P
Sbjct: 308 LASRCEVQVAYAIGKAEPVGLFVETFGTNTIDTDKIEQAISEVFDLRPAAIIRDLDLLRP 367
Query: 345 IYRQTSVYGHFGK 357
IY QT+ YGHFG+
Sbjct: 368 IYSQTAAYGHFGR 380
gb|AAF10215.1|AE001921_7 (AE001921) S-adenosylmethionine synthase [Deinococcus radiodurans]
Length = 408
Score = 336 bits (852), Expect = 2e-91
Identities = 173/383 (45%), Positives = 240/383 (62%), Gaps = 28/383 (7%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTES-YVDIP 65
+ESV+EGHPDK++D ++D++LDEF++++P S+V++E +VTTG+ +V GE+ + +VDI
Sbjct: 12 SESVSEGHPDKLSDFISDSILDEFLRQEPTSRVAVETLVTTGMAVVAGEVRAHTAHVDIQ 71
Query: 66 RVVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGI------------------- 106
+ VR ++ +GYTR GFDA+ AV+ +I EQSPEIA G+
Sbjct: 72 KTVREAVQRVGYTRANYGFDAEYSAVLVAIHEQSPEIASGVDHSEEWREMSEAERQKPEN 131
Query: 107 --SSEGAGDTAIVVGYATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVA 164
S GAGD ++ GYAT E P LMP PI++AH +T+R++E RK G P+LRPD K V
Sbjct: 132 AYSMVGAGDQGLMFGYATDETPELMPLPISLAHGLTRRLAELRKDGTLPYLRPDAKAQVT 191
Query: 165 MIYEDGKP-----SYVQSIVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKV 219
++ +G+P + V +IV H DV+ +R L E+T +
Sbjct: 192 VV-RNGEPHSATETAVDTIVISTQHSDDVTQEQIRADMLEHVIPAVIPAELLNEQTRYFI 250
Query: 220 NPTGRFVIGGPVADTGLTGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKH 279
NP+GRFVIGGP DTGLTGRKI+ D YG GG AFSGKDPTK DRS +Y AR +AK+
Sbjct: 251 NPSGRFVIGGPHGDTGLTGRKIIVDTYGGAVPHGGGAFSGKDPTKVDRSAAYYARYVAKN 310
Query: 280 VVAGGWAERCLVQIGYAFGLTEPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFL 339
+VA G A R LV+I YA G PV+ ++T+GT +S E L++ + F RP II L
Sbjct: 311 IVAAGLARRALVEIAYAIGRAHPVSLRVDTYGTGTVSDEKLDELIAAHFDARPQAIIAQL 370
Query: 340 DLRKPIYRQTSVYGHFGKENLPW 362
DL++PIY QT+ YGHFG+ PW
Sbjct: 371 DLQRPIYAQTAAYGHFGRPEFPW 393
sp|P56460|METK_HELPY S-ADENOSYLMETHIONINE SYNTHETASE (METHIONINE ADENOSYLTRANSFERASE)
(ADOMET SYNTHETASE) >gi|2313288|gb|AAD07267.1|
(AE000540) S-adenosylmethionine synthetase 2 (metX)
[Helicobacter pylori 26695]
Length = 385
Score = 335 bits (850), Expect = 4e-91
Identities = 171/356 (48%), Positives = 223/356 (62%), Gaps = 4/356 (1%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESVTEGHPDK+ADQ++DA+LD I++D +KV+ E +V+ G M+ GEL T Y +
Sbjct: 9 SESVTEGHPDKMADQISDAVLDYIIERDQKAKVACETLVSNGFCMITGELKTSVYAPMQE 68
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE----GAGDTAIVVGYAT 122
+ R V+K IGYT GFD + AV+ + EQSP+I G+ E GAGD ++ GYA
Sbjct: 69 IAREVVKKIGYTDALYGFDYRSAAVLNGVGEQSPDINQGVDREDGEIGAGDQGLMFGYAC 128
Query: 123 KEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYEDGKPSYVQSIVAYV 182
KE LMP PI +AH++T +++ RK PFLRPDGK V++ YE+ KP + +IV
Sbjct: 129 KETETLMPLPIHLAHQLTFALAQKRKDNTLPFLRPDGKSQVSVRYENNKPVSIDTIVIST 188
Query: 183 HHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADTGLTGRKIV 242
H P+VS HL+E +L + VNPTG+FVIGGP D GLTGRKI+
Sbjct: 189 QHSPEVSQKHLKEAVIEEIVYKVLSKEYLHDNIKFFVNPTGKFVIGGPQGDAGLTGRKII 248
Query: 243 SDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIGYAFGLTEP 302
D YG GG AFSGKDP+K DRS +Y AR +AK++VA G ++ VQ+ YA G+ EP
Sbjct: 249 VDTYGGSCPHGGGAFSGKDPSKVDRSAAYAARYVAKNLVASGVCDKATVQLAYAIGVIEP 308
Query: 303 VAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKPIYRQTSVYGHFGKE 358
V+ + T T K S LE VK VF L P IIE LDL +PIY TS YGHFG+E
Sbjct: 309 VSIYVNTHNTSKYSSAELEKCVKSVFKLTPKGIIESLDLLRPIYSLTSAYGHFGRE 364
sp|O83772|METK_TREPA S-ADENOSYLMETHIONINE SYNTHETASE (METHIONINE ADENOSYLTRANSFERASE)
(ADOMET SYNTHETASE) >gi|3323100 (AE001250)
S-adenosylmethionine synthetase (metK) [Treponema
pallidum]
Length = 396
Score = 333 bits (845), Expect = 1e-90
Identities = 165/366 (45%), Positives = 230/366 (62%), Gaps = 10/366 (2%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESV+EGHPDK+ DQ++DA+LD + +DP+S V+ E +T L+++GGE++T +++++ +
Sbjct: 7 SESVSEGHPDKLCDQISDAVLDACLSQDPHSCVACETFASTSLILIGGEISTRAHINLTQ 66
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGI---------SSEGAGDTAIV 117
+ R V DIGY ++G DA + AV+ QSP+IA G+ S+GAGD I+
Sbjct: 67 IARDVAADIGYVSADVGLDAASMAVLDMTHHQSPDIAQGVHGAGLKEFAGSQGAGDQGIM 126
Query: 118 VGYATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYEDGKPSYVQS 177
G+A +E P MP P+ AH + + + R + P+LRPD K V + YE +P + +
Sbjct: 127 FGFACRETPEFMPAPLMCAHAVVRYAATLRHERRVPWLRPDAKSQVTVQYEGHRPVRISA 186
Query: 178 IVAYVHHDPDVSINHLRE-LXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADTGL 236
+V HDP S +RE L L E T +NPTGRFVIGGP DTGL
Sbjct: 187 VVFSQQHDPSPSYETIRETLIEEIVRPALAPTGLLDENTRFFINPTGRFVIGGPFGDTGL 246
Query: 237 TGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIGYA 296
TGRKI+ D YG +G GG +FSGKD +K DRS +Y+AR IAK++VA AERC VQ+ YA
Sbjct: 247 TGRKIIVDTYGGMGRHGGGSFSGKDASKVDRSAAYMARYIAKNIVAADLAERCEVQLAYA 306
Query: 297 FGLTEPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKPIYRQTSVYGHFG 356
G+ PV+ IETFGT + S+ + AVK++F L PA I+ LDL P YR T+VYGHFG
Sbjct: 307 IGVPYPVSLRIETFGTARASESHITHAVKEIFDLTPAGIVRTLDLCAPRYRSTAVYGHFG 366
Query: 357 KENLPW 362
+E PW
Sbjct: 367 REQFPW 372
sp|Q9ZMN5|METK_HELPJ S-ADENOSYLMETHIONINE SYNTHETASE (METHIONINE ADENOSYLTRANSFERASE)
(ADOMET SYNTHETASE) >gi|4154690 (AE001456)
S-adenosylmethionine synthetase [Helicobacter pylori
J99]
Length = 385
Score = 333 bits (844), Expect = 2e-90
Identities = 171/356 (48%), Positives = 222/356 (62%), Gaps = 4/356 (1%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESVTEGHPDK+ADQ++DA+LD I++D +KV+ E +V+ G M+ GEL T Y +
Sbjct: 9 SESVTEGHPDKMADQISDAVLDYIIERDKKAKVACETLVSNGFCMITGELKTSVYAPMQE 68
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE----GAGDTAIVVGYAT 122
+ R V+K IGYT GFD + AV+ I EQSP+I G+ E GAGD ++ GYA
Sbjct: 69 IAREVVKKIGYTDALYGFDYRSAAVLNGIGEQSPDINQGVDREDGEIGAGDQGLMFGYAC 128
Query: 123 KEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYEDGKPSYVQSIVAYV 182
KE LMP PI +AH++ +++ RK PFLRPDGK V++ YE+ KP V +IV
Sbjct: 129 KETETLMPLPIHLAHQLAFALAQKRKDNTLPFLRPDGKSQVSVRYENNKPVSVDTIVIST 188
Query: 183 HHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADTGLTGRKIV 242
H P+VS HL+E +L + +NPTG+FVIGGP D GLTGRKI+
Sbjct: 189 QHSPEVSQKHLKEAVIEEIVYKVLPKEYLHDNIKFFINPTGKFVIGGPQGDAGLTGRKII 248
Query: 243 SDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIGYAFGLTEP 302
D YG GG AFSGKDP+K DRS +Y AR +AK++VA G ++ VQ+ YA G+ EP
Sbjct: 249 VDTYGGFCPHGGGAFSGKDPSKVDRSAAYAARYVAKNLVASGVCDKATVQLAYAIGVIEP 308
Query: 303 VAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKPIYRQTSVYGHFGKE 358
V+ + T T K S LE VK VF L P IIE LDL +PIY TS YGHFG+E
Sbjct: 309 VSIYVNTHNTSKHSSAELEKCVKSVFKLTPKGIIESLDLLRPIYSLTSAYGHFGRE 364
ref|NP_005902.1|| methionine adenosyltransferase II, alpha
>gi|400245|sp|P31153|METK_HUMAN S-ADENOSYLMETHIONINE
SYNTHETASE GAMMA FORM (METHIONINE ADENOSYLTRANSFERASE)
(ADOMET SYNTHETASE) (MAT-II) >gi|284394|pir||S27257
methionine adenosyltransferase (EC 2.5.1.6), renal -
human >gi|36327|emb|CAA48726| (X68836)
S-adenosylmethionine synthetase [Homo sapiens]
>gi|1583774|prf||2121386A Met
adenosyltransferase:SUBUNIT=alpha [Homo sapiens]
Length = 395
Score = 327 bits (830), Expect = 8e-89
Identities = 163/366 (44%), Positives = 231/366 (62%), Gaps = 10/366 (2%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESV EGHPDKI DQ++DA+LD +++DP +KV+ E + TG++++ GE+T+ + VD +
Sbjct: 22 SESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQK 81
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE------GAGDTAIVVGY 120
VVR +K IGY GFD TC V+ ++++QSP+IA G+ + GAGD ++ GY
Sbjct: 82 VVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGY 141
Query: 121 ATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYEDGK----PSYVQ 176
AT E MP I +AHK+ +++E R+ G P+LRPD K V + Y + P V
Sbjct: 142 ATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVH 201
Query: 177 SIVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADTGL 236
+IV V HD +V ++ +R+ +L E T + P+GRFVIGGP D GL
Sbjct: 202 TIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGL 261
Query: 237 TGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIGYA 296
TGRKI+ D YG G GG AFSGKD TK DRS +Y AR +AK +V GG R LVQ+ YA
Sbjct: 262 TGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYA 321
Query: 297 FGLTEPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKPIYRQTSVYGHFG 356
G++ P++ I +GT + S+ L + VKK F LRP I+ LDL+KPIY++T+ YGHFG
Sbjct: 322 IGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFG 381
Query: 357 KENLPW 362
+++ PW
Sbjct: 382 RDSFPW 387
sp|P72871|METK_SYNY3 S-ADENOSYLMETHIONINE SYNTHETASE (METHIONINE ADENOSYLTRANSFERASE)
(ADOMET SYNTHETASE) >gi|1651961|dbj|BAA16887| (D90901)
S-adenosylmethionine synthetase [Synechocystis sp.]
Length = 409
Score = 325 bits (824), Expect = 4e-88
Identities = 167/387 (43%), Positives = 238/387 (61%), Gaps = 34/387 (8%)
Query: 10 VTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPRVVR 69
+TEGHPDK+ DQ++D +LD + DP S+V+ E +V TGL +V GE+T++++++ ++R
Sbjct: 1 MTEGHPDKVCDQISDTILDALLTLDPNSRVAAETVVNTGLTLVTGEITSQAHINFVELIR 60
Query: 70 SVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE---------------GAGDT 114
I +IGYT + G+ A++CAV+ +IDEQSP+I+ G+++ GAGD
Sbjct: 61 QKIAEIGYTNADNGYSANSCAVMLAIDEQSPDISQGVTAAQEQRHALSDDELDKIGAGDQ 120
Query: 115 AIVVGYATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYEDGKPSY 174
++ GYA E P LMP PI++AH+I R+SE RK G+ +LRPDGK V+++YEDG P
Sbjct: 121 GLMFGYACNETPELMPLPISLAHRIALRLSEVRKSGQLAYLRPDGKTQVSILYEDGSPVA 180
Query: 175 VQSIVAYVHHDP---DVSINHLRELXXXXXXXXXXXXXFL-------TEKTSIKVNPTGR 224
+ +I+ HD D++ N + T+KT VNPTG+
Sbjct: 181 IDTILISTQHDEHIGDITDNDAVQAKIKADLWDVVVGHCFSDIALKPTDKTRFIVNPTGK 240
Query: 225 FVIGGPVADTGLTGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGG 284
FV+GGP D GLTGRKI+ D YG GG AFSGKDPTK DRS +Y AR +AK++VA G
Sbjct: 241 FVVGGPQGDAGLTGRKIIVDTYGGYSRHGGGAFSGKDPTKVDRSAAYAARYVAKNIVAAG 300
Query: 285 WAERCLVQIGYAFGLTEPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRK- 343
A++C VQ+ YA G+ PV+ I+TFGT K+ +E L + V F LRPA II+ L+LR
Sbjct: 301 LADKCEVQVSYAIGVARPVSVLIDTFGTGKVDEEKLLEVVLANFELRPAGIIQSLNLRNL 360
Query: 344 ------PIYRQTSVYGHFGKE--NLPW 362
Y+ + YGHFG+ +LPW
Sbjct: 361 PAERGGRFYQDVAAYGHFGRNDLDLPW 387
sp|P50306|METL_CAEEL PROBABLE S-ADENOSYLMETHIONINE SYNTHETASE C06E7.3 (METHIONINE
ADENOSYLTRANSFERASE) (ADOMET SYNTHETASE) >gi|1086604
(U41009) Similar to S-adenosylmethionine synthetase.
[Caenorhabditis elegans]
Length = 404
Score = 324 bits (823), Expect = 5e-88
Identities = 162/366 (44%), Positives = 232/366 (63%), Gaps = 10/366 (2%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESV+EGHPDK+ DQ++DA+LD + +DP++KV+ E + TG++M+ GE+T+++ VD
Sbjct: 10 SESVSEGHPDKMCDQISDAVLDAHLAQDPHAKVACETVTKTGMIMLCGEITSKAVVDYQV 69
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE------GAGDTAIVVGY 120
+VR+VIK IGY GFD TC V+ ++++QSPEIA G+ + GAGD I+ GY
Sbjct: 70 LVRNVIKKIGYDDSSKGFDYKTCNVLVALEQQSPEIAAGVHVDKDSDDVGAGDQGIMFGY 129
Query: 121 ATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIY--EDGK--PSYVQ 176
AT E MP + ++HK+ +++ E R+ G+ ++RPD K V + Y E G P V
Sbjct: 130 ATDETEEAMPLTLLLSHKLNRKLHELRRSGELEWVRPDSKTQVTIEYASEGGACVPLRVH 189
Query: 177 SIVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADTGL 236
++V H PD+S++ LR+ + +KT +NP G F+IGGP+ D GL
Sbjct: 190 TVVISTQHSPDISLDDLRKELIEKVIKAVIPANLIDDKTIYHLNPCGSFIIGGPMGDAGL 249
Query: 237 TGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIGYA 296
TGRKI+ D YG G GG AFSGKDPTK DRS +Y AR +AK +V G RCLVQ+ YA
Sbjct: 250 TGRKIIVDTYGGWGAHGGGAFSGKDPTKVDRSAAYAARWVAKSLVKAGLCRRCLVQVSYA 309
Query: 297 FGLTEPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKPIYRQTSVYGHFG 356
G+ +P++ + +FGT +S+E L V F LRP +II+ LDL++PIY T+ GHFG
Sbjct: 310 IGVAKPLSVMVFSFGTSALSEEDLLTIVNDNFDLRPGKIIKNLDLKRPIYEPTAENGHFG 369
Query: 357 KENLPW 362
N PW
Sbjct: 370 HNNFPW 375
sp|P18298|METK_RAT S-ADENOSYLMETHIONINE SYNTHETASE GAMMA FORM (METHIONINE
ADENOSYLTRANSFERASE) (ADOMET SYNTHETASE) (MAT-II)
>gi|111953|pir||A37118 methionine adenosyltransferase
(EC 2.5.1.6) - rat >gi|206846 (J05571)
S-adenosylmethionine synthetase (EC 2.5.1.6) [Rattus
norvegicus] >gi|1928858|dbj|BAA19170| (AB000717)
non-hepatic-type S-adenosylmethionine synthetase [Rattus
rattus]
Length = 395
Score = 324 bits (822), Expect = 7e-88
Identities = 162/366 (44%), Positives = 229/366 (62%), Gaps = 10/366 (2%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESV EGHPDKI DQ+ DA+LD +++DP +KV+ E + TG++++ GE+T+ + +D +
Sbjct: 22 SESVGEGHPDKICDQINDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAIDYQK 81
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE------GAGDTAIVVGY 120
VVR IK IGY GFD TC V+ ++++QSP+IA G+ + GAGD ++ GY
Sbjct: 82 VVREAIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGY 141
Query: 121 ATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYEDGK----PSYVQ 176
AT E MP I +AHK+ +++E R+ G P+LRPD K V + Y + P V
Sbjct: 142 ATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVIPIRVH 201
Query: 177 SIVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADTGL 236
+IV V HD +V ++ +R+ +L E T + P+GRFVIGGP D GL
Sbjct: 202 TIVISVQHDEEVCLDEMRDALKEKLIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGL 261
Query: 237 TGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIGYA 296
TGRKI+ D YG G GG AFSGKD TK DRS +Y AR +AK +V GG R LVQ+ YA
Sbjct: 262 TGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYA 321
Query: 297 FGLTEPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKPIYRQTSVYGHFG 356
G++ P++ I +GT + S+ L + VK F LRP I+ LDL+KPIY++T+ YGHFG
Sbjct: 322 IGVSHPLSISIFHYGTSQKSERELLEIVKNNFDLRPGVIVRDLDLKKPIYQRTAAYGHFG 381
Query: 357 KENLPW 362
+++ PW
Sbjct: 382 RDSFPW 387
sp|O60198|METK_SCHPO S-ADENOSYLMETHIONINE SYNTHETASE (METHIONINE ADENOSYLTRANSFERASE)
(ADOMET SYNTHETASE) >gi|3021570|emb|CAA04941| (AJ001705)
S-adenosylmethionine synthetase [Schizosaccharomyces
pombe] >gi|3184108|emb|CAA19323.1| (AL023780)
s-adenosylmethionine synthetase [Schizosaccharomyces
pombe]
Length = 382
Score = 324 bits (821), Expect = 9e-88
Identities = 168/366 (45%), Positives = 222/366 (59%), Gaps = 10/366 (2%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESV EGHPDKI DQ++DA+LD +K DP+SKV+ E TG+VMV GE+TT S +D +
Sbjct: 9 SESVGEGHPDKICDQISDAILDACLKDDPFSKVACETASKTGMVMVFGEITTRSQIDYQK 68
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE------GAGDTAIVVGY 120
V+R+ IK IGY E GFD TC V+ +I++QSP+IA G+ E GAGD I+ GY
Sbjct: 69 VIRNTIKSIGYDDSEKGFDYKTCNVLVAIEQQSPDIAQGLHYEKALEELGAGDQGIMFGY 128
Query: 121 ATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYEDGK----PSYVQ 176
AT E P +P I +AHK+ +S R+ G P+LRPD K V + YE+ P V
Sbjct: 129 ATDETPEKLPLTILLAHKLNAAMSVARRDGSLPWLRPDTKTQVTIEYEEENGAVIPRRVD 188
Query: 177 SIVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADTGL 236
+IV H +S LR L EKT + P+GRFV+GGP D GL
Sbjct: 189 TIVVSAQHADSISTEDLRSEILEKIIKPTVPAHLLDEKTVYHIQPSGRFVVGGPQGDAGL 248
Query: 237 TGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIGYA 296
TGRKI+ D YG G GG AFSGKD +K DRS +Y AR IAK +VA G A RCLVQ+ YA
Sbjct: 249 TGRKIIVDTYGGWGAHGGGAFSGKDYSKVDRSAAYAARWIAKSLVAAGLARRCLVQLSYA 308
Query: 297 FGLTEPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKPIYRQTSVYGHFG 356
G+ EP++ + T+GT + L + ++K F LRP +++ L L+ P Y T+ YGHF
Sbjct: 309 IGVAEPLSIFVNTYGTSSKTSAELVEIIRKNFDLRPGVLVKSLKLQTPFYLSTASYGHFT 368
Query: 357 KENLPW 362
++ PW
Sbjct: 369 DQSKPW 374
sp|P77899|METK_MYCTU S-ADENOSYLMETHIONINE SYNTHETASE (METHIONINE ADENOSYLTRANSFERASE)
(ADOMET SYNTHETASE) >gi|3256013|emb|CAB02194| (Z80108)
metK [Mycobacterium tuberculosis]
Length = 403
Score = 323 bits (818), Expect = 2e-87
Identities = 171/381 (44%), Positives = 226/381 (58%), Gaps = 25/381 (6%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTT---ESYVD 63
+ESVTEGHPDKI D ++D++LD + DP S+V++E +VTTG V V GE+TT E++ D
Sbjct: 10 SESVTEGHPDKICDAISDSVLDALLAADPRSRVAVETLVTTGQVHVVGEVTTSAKEAFAD 69
Query: 64 IPRVVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGIS---------------S 108
I VR+ I +IGY + GFD TC V I QSP+IA G+ S
Sbjct: 70 ITNTVRARILEIGYDSSDKGFDGATCGVNIGIGAQSPDIAQGVDTAHEARVEGAADPLDS 129
Query: 109 EGAGDTAIVVGYATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYE 168
+GAGD ++ GYA P LMP PI +AH++++R++E RK G P+LRPDGK V + YE
Sbjct: 130 QGAGDQGLMFGYAINATPELMPLPIALAHRLSRRLTEVRKNGVLPYLRPDGKTQVTIAYE 189
Query: 169 DGKPSYVQSIVAYVHHDPDVSINH-----LRELXXXXXXXXXXXXXFLTEKTSIKVNPTG 223
D P + ++V H D+ + +RE + VNPTG
Sbjct: 190 DNVPVRLDTVVISTQHAADIDLEKTLDPDIREKVLNTVLDDLAHETLDASTVRVLVNPTG 249
Query: 224 RFVIGGPVADTGLTGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAG 283
+FV+GGP+ D GLTGRKI+ D YG GG AFSGKDP+K DRS +Y R +AK+VVA
Sbjct: 250 KFVLGGPMGDAGLTGRKIIVDTYGGWARHGGGAFSGKDPSKVDRSAAYAMRWVAKNVVAA 309
Query: 284 GWAERCLVQIGYAFGLTEPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRK 343
G AER VQ+ YA G PV +ETFGTE +E A+ +VF LRP II L+L +
Sbjct: 310 GLAERVEVQVAYAIGKAAPVGLFVETFGTETEDPVKIEKAIGEVFDLRPGAIIRDLNLLR 369
Query: 344 PIYRQTSVYGHFGKEN--LPW 362
PIY T+ YGHFG+ + LPW
Sbjct: 370 PIYAPTAAYGHFGRTDVELPW 390
ref|NP_000420.1|| methionine adenosyltransferase I, alpha
>gi|417297|sp|Q00266|METL_HUMAN S-ADENOSYLMETHIONINE
SYNTHETASE ALPHA AND BETA FORMS (METHIONINE
ADENOSYLTRANSFERASE) (ADOMET SYNTHETASE) (MAT-I/III)
>gi|479655|pir||S35056 methionine adenosyltransferase
(EC 2.5.1.6) - human >gi|36329|emb|CAA48822| (X69078)
methionine adenosyltransferase [Homo sapiens]
Length = 395
Score = 320 bits (811), Expect = 1e-86
Identities = 163/366 (44%), Positives = 225/366 (60%), Gaps = 10/366 (2%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESV EGHPDKI DQ++DA+LD +K+DP +KV+ E + TG+V++ GE+T+ + VD R
Sbjct: 22 SESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVCKTGMVLLCGEITSMAMVDYQR 81
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE------GAGDTAIVVGY 120
VVR IK IGY GFD TC V+ ++++QSP+IA + + GAGD ++ GY
Sbjct: 82 VVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQCVHLDRNEEDVGAGDQGLMFGY 141
Query: 121 ATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYEDGK----PSYVQ 176
AT E MP I +AHK+ R+++ R+ G P+LRPD K V + Y P +
Sbjct: 142 ATDETEECMPLTIILAHKLNARMADLRRSGLLPWLRPDSKTQVTVQYMQDNGAVIPVRIH 201
Query: 177 SIVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADTGL 236
+IV V H+ D+++ +R +L E T + P+GRFVIGGP D G+
Sbjct: 202 TIVISVQHNEDITLEEMRRALKEQVIRAVVPAKYLDEDTVYHLQPSGRFVIGGPQGDAGV 261
Query: 237 TGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIGYA 296
TGRKI+ D YG G GG AFSGKD TK DRS +Y AR +AK +V G R LVQ+ YA
Sbjct: 262 TGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYA 321
Query: 297 FGLTEPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKPIYRQTSVYGHFG 356
G+ EP++ I T+GT + ++ L D V K F LRP I+ LDL+KPIY++T+ YGHFG
Sbjct: 322 IGVAEPLSISIFTYGTSQKTERELLDVVHKNFDLRPGVIVRDLDLKKPIYQKTACYGHFG 381
Query: 357 KENLPW 362
+ PW
Sbjct: 382 RSEFPW 387
sp|O17680|METM_CAEEL PROBABLE S-ADENOSYLMETHIONINE SYNTHETASE C49F5.1 (METHIONINE
ADENOSYLTRANSFERASE) (ADOMET SYNTHETASE)
>gi|3875064|emb|CAB03975.1| (Z81485) predicted using
Genefinder; Similarity to Human S-adenosylmethionine
synthetase (SW:Q00266); cDNA EST EMBL:Z14890 comes from
this gene; cDNA EST EMBL:M89315 comes from this gene;
cDNA EST CEMSA33F comes from this gen...
Length = 403
Score = 319 bits (810), Expect = 2e-86
Identities = 159/366 (43%), Positives = 225/366 (61%), Gaps = 10/366 (2%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESV+EGHPDK+ DQ++DA+LD +K+DP +KV+ E + TG+VM+ GE+T+++ VD
Sbjct: 9 SESVSEGHPDKMCDQISDAVLDAHLKQDPNAKVACETVTKTGMVMLCGEITSKAVVDYQV 68
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGI------SSEGAGDTAIVVGY 120
+VR VI+ IG+T +GFD TC V+ ++++QSPEIA G+ GAGD I+ GY
Sbjct: 69 LVRRVIEKIGFTDSSIGFDHKTCNVLVALEQQSPEIAAGVHVNKDGEDVGAGDQGIMFGY 128
Query: 121 ATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYEDGK----PSYVQ 176
AT E MP + ++HKI + + R+ G P++RPD K V + YE P V
Sbjct: 129 ATDETEETMPLTLILSHKINAELHKLRRNGTLPWVRPDSKSQVTIEYESRHGATIPLRVH 188
Query: 177 SIVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADTGL 236
++V H PDV++ LRE L E T +NP G F++GGP+ D G+
Sbjct: 189 TVVVSTQHSPDVTLEKLRETILADVIKKVIPASLLDESTVFHINPCGTFIVGGPMGDAGV 248
Query: 237 TGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIGYA 296
TGRKI+ D YG G GG AFSGKDPTK DRS +Y AR +A +V G A+R LVQ+ YA
Sbjct: 249 TGRKIIVDTYGGWGAHGGGAFSGKDPTKVDRSAAYAARWVATSLVKAGLAKRVLVQLSYA 308
Query: 297 FGLTEPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKPIYRQTSVYGHFG 356
G+ +P++ + FGT ++ E L V+ F L P +II+ LDL++PIY +T+ GHFG
Sbjct: 309 IGIAKPISVLVYAFGTSPLTDEELHQIVEDSFDLTPGKIIKELDLKRPIYEKTAENGHFG 368
Query: 357 KENLPW 362
PW
Sbjct: 369 HSEFPW 374
pir||A47151 methionine adenosyltransferase (EC 2.5.1.6) - mouse
Length = 396
Score = 319 bits (810), Expect = 2e-86
Identities = 163/366 (44%), Positives = 225/366 (60%), Gaps = 10/366 (2%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESV EGHPDKI DQ++DA+LD +K+DP +KV+ E + TG+V++ GE+T+ + VD R
Sbjct: 23 SESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVCKTGMVLLCGEITSVAMVDYQR 82
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE------GAGDTAIVVGY 120
VVR IK IGY GFD TC V+ ++++QSP+IA + + GAGD ++ GY
Sbjct: 83 VVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQCVHLDRNEEDVGAGDQGLMFGY 142
Query: 121 ATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYEDGK----PSYVQ 176
AT E MP I +AHK+ RI++ R+ G P+LRPD K V + Y P +
Sbjct: 143 ATDETEECMPLTIVLAHKLNTRIADLRRSGVLPWLRPDSKTQVTVQYMQDNGAVIPVRIH 202
Query: 177 SIVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADTGL 236
+IV V H+ D+++ ++E +L E T + P+GRFVIGGP D G+
Sbjct: 203 TIVISVQHNEDITLEAMQEALKEQVIKAVVPARYLDEDTVYHLQPSGRFVIGGPQGDAGV 262
Query: 237 TGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIGYA 296
TGRKI+ D YG G GG AFSGKD TK DRS +Y AR +AK +V G R LVQ+ YA
Sbjct: 263 TGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYA 322
Query: 297 FGLTEPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKPIYRQTSVYGHFG 356
G+ EP++ I T+GT ++ L + V K F LRP I+ LDL+KPIY++T+ YGHFG
Sbjct: 323 IGVAEPLSISIFTYGTSNKTERELLEVVNKNFDLRPGVIVRDLDLKKPIYQKTACYGHFG 382
Query: 357 KENLPW 362
+ PW
Sbjct: 383 RSEFPW 388
sp|P13444|METL_RAT S-ADENOSYLMETHIONINE SYNTHETASE ALPHA AND BETA FORMS (METHIONINE
ADENOSYLTRANSFERASE) (ADOMET SYNTHETASE) (MAT-I/III)
>gi|92483|pir||S06114 methionine adenosyltransferase (EC
2.5.1.6) - rat >gi|57184|emb|CAA33754| (X15734)
s-adenosylmethionine synthetase [Rattus norvegicus]
Length = 397
Score = 319 bits (809), Expect = 2e-86
Identities = 164/367 (44%), Positives = 227/367 (61%), Gaps = 11/367 (2%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESV EGHPDKI DQ++DA+LD +K+DP +KV+ E + TG+V++ GE+T+ + +D R
Sbjct: 23 SESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVCKTGMVLLCGEITSMAMIDYQR 82
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE------GAGDTAIVVGY 120
VVR IK IGY GFD TC V+ ++++QSP+IA + + GAGD ++ GY
Sbjct: 83 VVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQCVHLDRNEEDVGAGDQGLMFGY 142
Query: 121 ATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYEDGK----PSYVQ 176
AT E MP I +AHK+ R+++ R+ G P+LRPD K V + Y P V
Sbjct: 143 ATDETEECMPLTIVLAHKLNTRMADLRRSGVLPWLRPDSKTQVTVQYVQDNGAVIPVRVH 202
Query: 177 SIVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADTGL 236
+IV V H+ D+++ +RE +L E T + P+GRFVIGGP D G+
Sbjct: 203 TIVISVQHNEDITLEAMREALKEQVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGV 262
Query: 237 TGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIGYA 296
TGRKI+ D YG G GG AFSGKD TK DRS +Y AR +AK +V G R LVQ+ YA
Sbjct: 263 TGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYA 322
Query: 297 FGLTEPVAFDIETFGT-EKISKEILEDAVKKVFPLRPAEIIEFLDLRKPIYRQTSVYGHF 355
G+ EP++ I T+GT +K ++ L + V K F LRP I+ LDL+KPIY++T+ YGHF
Sbjct: 323 IGVAEPLSISIFTYGTSKKTERDELLEVVNKNFDLRPGVIVRDLDLKKPIYQKTACYGHF 382
Query: 356 GKENLPW 362
G+ PW
Sbjct: 383 GRSEFPW 389
sp|P50305|METK_CAEEL PROBABLE S-ADENOSYLMETHIONINE SYNTHETASE C06E7.1 (METHIONINE
ADENOSYLTRANSFERASE) (ADOMET SYNTHETASE) >gi|1086605
(U41009) Similar to S-adenosylmethionine synthetase.
[Caenorhabditis elegans]
Length = 404
Score = 318 bits (807), Expect = 4e-86
Identities = 160/366 (43%), Positives = 229/366 (61%), Gaps = 10/366 (2%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESV+EGHPDK+ DQ++DA+LD + +DP++KV+ E + TG++M+ GE+T+++ VD
Sbjct: 10 SESVSEGHPDKMCDQISDAVLDAHLAQDPHAKVACETVTKTGMIMLCGEITSKAVVDYQV 69
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE------GAGDTAIVVGY 120
+VR+VIK IGY GFD TC V+ ++++QSPEIA G+ + GAGD I+ GY
Sbjct: 70 LVRNVIKKIGYDDSSKGFDYKTCNVLVALEQQSPEIAAGVHVDKDSDDVGAGDQGIMFGY 129
Query: 121 ATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIY--EDGK--PSYVQ 176
AT E MP + ++HK+ +++ E R+ G+ ++RPD K V + Y E G P V
Sbjct: 130 ATDETEEAMPLTLLLSHKLNRKLHELRRSGELEWVRPDSKTQVTIEYASEGGACVPLRVH 189
Query: 177 SIVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADTGL 236
++V H PD+S++ LR+ + +KT +NP G F+IGGP+ D GL
Sbjct: 190 TVVISTQHSPDISLDDLRKELIEKVIKAVIPANLIDDKTIYHLNPCGSFIIGGPMGDAGL 249
Query: 237 TGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIGYA 296
TGRKI+ D YG G GG AFSGKDPTK DRS +Y AR +AK +V G RCLVQ+ YA
Sbjct: 250 TGRKIIVDTYGGWGAHGGGAFSGKDPTKVDRSAAYAARWVAKSLVKSGLCRRCLVQVSYA 309
Query: 297 FGLTEPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKPIYRQTSVYGHFG 356
G+ +P++ + +FGT +++ L V F LRP II+ LDL+KPIY T+ GHFG
Sbjct: 310 IGVAKPLSVMVFSFGTSALNEGELLKIVNDNFDLRPGMIIKDLDLKKPIYEPTAENGHFG 369
Query: 357 KENLPW 362
PW
Sbjct: 370 HNEFPW 375
sp|P50304|METK_ASCIM S-ADENOSYLMETHIONINE SYNTHETASE (METHIONINE ADENOSYLTRANSFERASE)
(ADOMET SYNTHETASE) >gi|836960 (U21548)
S-adenosylmethionine synthetase [Ascobolus immersus]
Length = 393
Score = 318 bits (807), Expect = 4e-86
Identities = 163/368 (44%), Positives = 230/368 (62%), Gaps = 12/368 (3%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESV EGHPDKIADQ++DA+LD + +DP SKV+ E TG++MV GE+TT++++D +
Sbjct: 18 SESVGEGHPDKIADQVSDAVLDACLAEDPLSKVACETATKTGMIMVFGEITTKAHLDYQK 77
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE------GAGDTAIVVGY 120
++R+ +KDIGY GFD TC V+ +I++QSP+IA G+ E GAGD I+ GY
Sbjct: 78 IIRNAVKDIGYDDSAKGFDYKTCNVLVAIEQQSPDIAQGLHYEKALEELGAGDQGIMFGY 137
Query: 121 ATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYE-DGK---PSYVQ 176
AT E P L+P + +AH++ +++ R+ G P+LRPD K V + YE DG P V+
Sbjct: 138 ATDETPELLPLTLLLAHQLNANMAKARRDGSLPWLRPDTKTQVTIEYEHDGGAVVPKKVK 197
Query: 177 SIVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADTGL 236
++V H D++ LR+ +L E T + P+G F+IGGP D GL
Sbjct: 198 TVVVSAQHSEDITTEELRKEILEKIIKTTIPAKYLDEDTVFHIQPSGLFIIGGPQGDAGL 257
Query: 237 TGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIGYA 296
TGRKI+ D YG G GG AFSGKD +K DRS +YLAR IAK +V G RCLVQ+ YA
Sbjct: 258 TGRKIIVDTYGGWGAHGGGAFSGKDYSKVDRSAAYLARWIAKSLVTAGLVRRCLVQLSYA 317
Query: 297 FGLTEPVAFDIETFGT--EKISKEILEDAVKKVFPLRPAEIIEFLDLRKPIYRQTSVYGH 354
G+ EP++ +E +GT E + + L + ++K F +RP I++ LDL KPIY QT+ GH
Sbjct: 318 IGVAEPLSIFVEDYGTSAEGRTSDQLVEIIRKNFDMRPGVIVQELDLAKPIYFQTAKNGH 377
Query: 355 FGKENLPW 362
F + W
Sbjct: 378 FTNQEFAW 385
pir||S27363 methionine adenosyltransferase (EC 2.5.1.6) - human
>gi|220066|dbj|BAA08355| (D49357) S-adenosylmethionine
synthetase [Homo sapiens]
Length = 395
Score = 317 bits (804), Expect = 9e-86
Identities = 162/366 (44%), Positives = 224/366 (60%), Gaps = 10/366 (2%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESV EGHPDKI DQ++DA+LD +K+DP +KV+ E + TG+V++ GE+T+ + VD R
Sbjct: 22 SESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVCKTGMVLLCGEITSMAMVDYQR 81
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE------GAGDTAIVVGY 120
VVR IK IGY GFD TC V+ ++++QSP+IA + + GAGD ++ GY
Sbjct: 82 VVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQCVHLDRNEEDVGAGDQGLMFGY 141
Query: 121 ATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYEDGK----PSYVQ 176
AT E MP I +AHK+ R+++ R+ G P+LRPD K V + Y P +
Sbjct: 142 ATDETEECMPLTIILAHKLNARMADLRRSGLLPWLRPDSKTQVTVQYMQDNGAVIPVRIH 201
Query: 177 SIVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADTGL 236
+IV V H+ D+++ +R +L E T + P+GRFVIGGP D G+
Sbjct: 202 TIVISVQHNEDITLEEMRRALKEQVIRAVVPAKYLDEDTVYHLQPSGRFVIGGPQGDAGV 261
Query: 237 TGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIGYA 296
TGRKI+ D Y G GG AFSGKD TK DRS +Y AR +AK +V G R LVQ+ YA
Sbjct: 262 TGRKIIVDTYAAWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYA 321
Query: 297 FGLTEPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKPIYRQTSVYGHFG 356
G+ EP++ I T+GT + ++ L D V K F LRP I+ LDL+KPIY++T+ YGHFG
Sbjct: 322 IGVAEPLSISIFTYGTSQKTERELLDVVHKNFDLRPGVIVRDLDLKKPIYQKTACYGHFG 381
Query: 357 KENLPW 362
+ PW
Sbjct: 382 RSEFPW 387
sp|P48466|METK_NEUCR S-ADENOSYLMETHIONINE SYNTHETASE (METHIONINE ADENOSYLTRANSFERASE)
(ADOMET SYNTHETASE) >gi|2133316|pir||S65800 methionine
adenosyltransferase (EC 2.5.1.6) - Neurospora crassa
>gi|882335 (U21547) S-adenosylmethionine synthetase
[Neurospora crassa] >gi|1589103|prf||2210293A
Met(S-adenosyl) synthetase [Neurospora crassa]
Length = 395
Score = 317 bits (803), Expect = 1e-85
Identities = 166/367 (45%), Positives = 225/367 (61%), Gaps = 11/367 (2%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESV EGHPDKIADQ++DA+LD + +DP SKV+ E TG++MV GE+TT++ +D +
Sbjct: 21 SESVGEGHPDKIADQVSDAILDACLAEDPLSKVACETATKTGMIMVFGEITTKAKLDYQK 80
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE------GAGDTAIVVGY 120
VVR+ IKDIGY GFD TC ++ +I+EQSP+IA G+ + GAGD I+ GY
Sbjct: 81 VVRNAIKDIGYDDSSKGFDYKTCNLLVAIEEQSPDIAQGLHLDDRLENLGAGDQGIMFGY 140
Query: 121 ATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYEDGK----PSYVQ 176
AT E P L P + AHK+ +S R+ G P+LRPD K V + Y+ P V
Sbjct: 141 ATDETPELFPLTLLFAHKLNAAMSAARRDGSLPWLRPDTKTQVTIEYKHDNGAVVPLRVD 200
Query: 177 SIVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADTGL 236
++V H P+++ LR+ +L EKT + P+G FVIGGP D GL
Sbjct: 201 TVVVSAQHAPEITTEELRKEILEKIIKTTIPAKYLDEKTVYHIQPSGLFVIGGPQGDAGL 260
Query: 237 TGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIGYA 296
TGRKI+ D YG G GG AFSGKD +K DRS +Y+ R IAK +VA G A R LVQ+ YA
Sbjct: 261 TGRKIIVDTYGGWGAHGGGAFSGKDFSKVDRSAAYVGRWIAKSLVAAGLARRALVQLSYA 320
Query: 297 FGLTEPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKPIYRQTSVYGHFG 356
G+ EP++ ++T+GT + E L ++ F LRP I++ LDL KPIY QT+ GHFG
Sbjct: 321 IGVAEPLSIYVDTYGTSDKTSEELVQIIRNNFDLRPGVIVKELDLAKPIYLQTAKNGHFG 380
Query: 357 -KENLPW 362
++ W
Sbjct: 381 TNQSFSW 387
gi|172534 (J03477) S-adenosylmethionine synthetase [Saccharomyces cerevisiae]
Length = 382
Score = 312 bits (790), Expect = 4e-84
Identities = 159/366 (43%), Positives = 220/366 (59%), Gaps = 10/366 (2%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESV EGHPDKI DQ++DA+LD + +DP+SKV+ E TG++MV GE+TT++ +D +
Sbjct: 9 SESVGEGHPDKICDQVSDAILDACLAEDPHSKVACETAAKTGMIMVFGEITTKAQLDYQK 68
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE------GAGDTAIVVGY 120
+VR IK IGY GFD TC V+ +I++QSP+IA G+ E GAGD I+ GY
Sbjct: 69 IVRDTIKKIGYDDSAKGFDYKTCNVLVAIEQQSPDIAQGVHEEKDLEDIGAGDQGIMFGY 128
Query: 121 ATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYEDGK----PSYVQ 176
AT E P +P I +AHK+ +++ R+ G +LRPD K V + Y+D P +
Sbjct: 129 ATDETPEGLPLTILLAHKLNMAMADARRDGSLAWLRPDTKTQVTVEYKDDHGRWVPQRID 188
Query: 177 SIVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADTGL 236
++V H +++ LR L E T + P+GRFVIGGP DTGL
Sbjct: 189 TVVVSAQHADEITTEDLRAQLKSEIIEKVIPRDMLDENTKYFIQPSGRFVIGGPQGDTGL 248
Query: 237 TGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIGYA 296
TGRKI+ DAYG GG AFSGKD +K DRS +Y AR +AK +VA G +R VQ YA
Sbjct: 249 TGRKIIVDAYGGASSVGGGAFSGKDYSKVDRSAAYAARWVAKSLVAAGLCKRVQVQFSYA 308
Query: 297 FGLTEPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKPIYRQTSVYGHFG 356
G+ EP++ ++T+GT S E + D + K F LRP +++ LDL +P Y T+ YGHF
Sbjct: 309 IGIAEPLSLHVDTYGTATKSDEEIIDIISKNFDLRPGVLVKELDLARPFYLPTASYGHFT 368
Query: 357 KENLPW 362
+ PW
Sbjct: 369 NQEYPW 374
ref|NP_013281.1|SAM1| S-adenosylmethionine synthetase; Sam1p
>gi|1346525|sp|P10659|METK_YEAST S-ADENOSYLMETHIONINE
SYNTHETASE 1 (METHIONINE ADENOSYLTRANSFERASE 1) (ADOMET
SYNTHETASE 1) >gi|1071840|pir||S51425 methionine
adenosyltransferase (EC 2.5.1.6) 1 - yeast
(Saccharomyces cerevisiae) >gi|577201 (U17246) Sam1p:
S-adenosylmethionine synthetase [Saccharomyces
cerevisiae]
Length = 382
Score = 311 bits (789), Expect = 5e-84
Identities = 159/366 (43%), Positives = 220/366 (59%), Gaps = 10/366 (2%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESV EGHPDKI DQ++DA+LD + +DP+SKV+ E TG++MV GE+TT++ +D +
Sbjct: 9 SESVGEGHPDKICDQVSDAILDACLAEDPHSKVACETAAKTGMIMVFGEITTKAQLDYQK 68
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE------GAGDTAIVVGY 120
+VR IK IGY GFD TC V+ +I++QSP+IA G+ E GAGD I+ GY
Sbjct: 69 IVRDTIKKIGYDDSAKGFDYKTCNVLVAIEQQSPDIAQGVHEEKDLEDIGAGDQGIMFGY 128
Query: 121 ATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYEDGK----PSYVQ 176
AT E P +P I +AHK+ +++ R+ G +LRPD K V + Y+D P +
Sbjct: 129 ATDETPEGLPLTILLAHKLNMAMADARRDGSLAWLRPDTKTQVTVEYKDDHGRWVPQRID 188
Query: 177 SIVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADTGL 236
++V H +++ LR L E T + P+GRFVIGGP D GL
Sbjct: 189 TVVVSAQHADEITTEDLRAQLKSEIIEKVIPRDMLDENTKYFIQPSGRFVIGGPQGDAGL 248
Query: 237 TGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIGYA 296
TGRKI+ DAYG GG AFSGKD +K DRS +Y AR +AK +VA G +R VQ YA
Sbjct: 249 TGRKIIVDAYGGASSVGGGAFSGKDYSKVDRSAAYAARWVAKSLVAAGLCKRVQVQFSYA 308
Query: 297 FGLTEPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKPIYRQTSVYGHFG 356
G+ EP++ ++T+GT S E + D + K F LRP +++ LDL +PIY T+ YGHF
Sbjct: 309 IGIAEPLSLHVDTYGTATKSDEEIIDIISKNFDLRPGVLVKELDLARPIYLPTASYGHFT 368
Query: 357 KENLPW 362
+ PW
Sbjct: 369 NQEYPW 374
ref|NP_010790.1|SAM2| S-adenosylmethionine synthetase; Sam2p
>gi|127049|sp|P19358|METL_YEAST S-ADENOSYLMETHIONINE
SYNTHETASE 2 (METHIONINE ADENOSYLTRANSFERASE 2) (ADOMET
SYNTHETASE 2) >gi|83324|pir||A31398 methionine
adenosyltransferase (EC 2.5.1.6) 2 - yeast
(Saccharomyces cerevisiae) >gi|295659 (M23368)
S-adenosylmethionine synthetase [Saccharomyces
cerevisiae] >gi|927772 (U33057) Sam2p:
S-adenosylmethionine synthetase; CAI: 0.50
[Saccharomyces cerevisiae]
Length = 384
Score = 311 bits (789), Expect = 5e-84
Identities = 160/366 (43%), Positives = 222/366 (59%), Gaps = 10/366 (2%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESV EGHPDKI DQ++DA+LD +++DP+SKV+ E TG++MV GE+TT++ +D +
Sbjct: 11 SESVGEGHPDKICDQVSDAILDACLEQDPFSKVACETAAKTGMIMVFGEITTKARLDYQQ 70
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE------GAGDTAIVVGY 120
+VR IK IGY GFD TC V+ +I++QSP+IA G+ E GAGD I+ GY
Sbjct: 71 IVRDTIKKIGYDDSAKGFDYKTCNVLVAIEQQSPDIAQGLHYEKSLEDLGAGDQGIMFGY 130
Query: 121 ATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYEDGK----PSYVQ 176
AT E P +P I +AHK+ +++ R+ G P+LRPD K V + YED P +
Sbjct: 131 ATDETPEGLPLTILLAHKLNMAMADARRDGSLPWLRPDTKTQVTVEYEDDNGRWVPKRID 190
Query: 177 SIVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADTGL 236
++V H ++S LR L E T + P+GRFVIGGP D GL
Sbjct: 191 TVVISAQHADEISTADLRTQLQKDIVEKVIPKDMLDENTKYFIQPSGRFVIGGPQGDAGL 250
Query: 237 TGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIGYA 296
TGRKI+ DAYG GG AFSGKD +K DRS +Y AR +AK +VA G +R VQ YA
Sbjct: 251 TGRKIIVDAYGGASSVGGGAFSGKDYSKVDRSAAYAARWVAKSLVAAGLCKRVQVQFSYA 310
Query: 297 FGLTEPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKPIYRQTSVYGHFG 356
G+ EP++ ++T+GT S + + + +KK F LRP +++ LDL +PIY T+ YGHF
Sbjct: 311 IGIAEPLSLHVDTYGTATKSDDEIIEIIKKNFDLRPGVLVKELDLARPIYLPTASYGHFT 370
Query: 357 KENLPW 362
+ W
Sbjct: 371 NQEYSW 376
sp|P40320|METK_DROME S-ADENOSYLMETHIONINE SYNTHETASE (METHIONINE ADENOSYLTRANSFERASE)
(ADOMET SYNTHETASE) >gi|542585|pir||S41917 methionine
adenosyltransferase (EC 2.5.1.6) - fruit fly (Drosophila
melanogaster) >gi|452838|emb|CAA54567| (X77392)
methionine adenosyltransferase [Drosophila melanogaster]
Length = 405
Score = 310 bits (787), Expect = 9e-84
Identities = 155/364 (42%), Positives = 222/364 (60%), Gaps = 10/364 (2%)
Query: 9 SVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPRVV 68
SV EGHPDK+ DQ++DA+LD +K+DP +KV+ E + TG++++ GE+T+++ VD +V+
Sbjct: 35 SVGEGHPDKMCDQISDAILDAHLKQDPNAKVACETVAKTGMILLCGEITSKAVVDYQKVI 94
Query: 69 RSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE------GAGDTAIVVGYAT 122
R ++ IGY GFD TC V+ ++D+QSPEIA G+ GAGD I+ GYAT
Sbjct: 95 RETVQHIGYDDSSKGFDFKTCNVLLALDQQSPEIAAGVHVNRAEEEIGAGDQGIMFGYAT 154
Query: 123 KEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIY----EDGKPSYVQSI 178
E MP + +AHK+ ++I+E R+ F + RPD K V Y P V +I
Sbjct: 155 DETEECMPLTVVLAHKLNEKIAELRRSDVFWWARPDSKTQVTCEYLFNQGSAVPKRVHTI 214
Query: 179 VAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADTGLTG 238
V + H +S+ LR ++ T + +NP G FVIGGP+ D GLTG
Sbjct: 215 VVSMQHSEKISLETLRSEVMEKVVKVVIPAKYIDANTIVHINPCGLFVIGGPMGDAGLTG 274
Query: 239 RKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIGYAFG 298
RKI+ D YG G G AFSGKD TK DRS +Y AR +AK +V G +RCLVQ+ YA G
Sbjct: 275 RKIIVDTYGGWGAHGAGAFSGKDFTKVDRSAAYAARWVAKSLVKAGLCKRCLVQVSYAIG 334
Query: 299 LTEPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKPIYRQTSVYGHFGKE 358
L EP++ + +GT S++ L D +++ F LRP +I++ L+LR+PIY++TS YGHFG+
Sbjct: 335 LAEPLSITVFDYGTSHKSQKELLDIIRRNFDLRPGKIVKDLNLRQPIYQRTSTYGHFGRA 394
Query: 359 NLPW 362
W
Sbjct: 395 GFSW 398
pir||SYECSM methionine adenosyltransferase (EC 2.5.1.6) - Escherichia coli
>gi|146839 (K02129) S-adenosylmethionine synthetase
[Escherichia coli]
Length = 384
Score = 310 bits (785), Expect = 2e-83
Identities = 161/367 (43%), Positives = 229/367 (61%), Gaps = 9/367 (2%)
Query: 3 NLRMAESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTES-Y 61
+L +ESV+EGHPDKIADQ++DA+LD +++DP ++V+ E V TG+ + +
Sbjct: 4 HLFTSESVSEGHPDKIADQISDAVLDAILEQDPKARVACETYVKTGIGFSWRRNHHQRPW 63
Query: 62 VDIPRVVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGIS-----SEGAGDTAI 116
VDI + R+ +++IGY ++GFDA++CAV+ +I +QSP+I G+ +GAGD +
Sbjct: 64 VDIEEITRNTVREIGYVHSDMGFDANSCAVLSAIGKQSPDINQGVDRADPLEQGAGDQGL 123
Query: 117 VVGYATKEAPN-LMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYEDGKPSYV 175
V P LMP PIT AH++ +R +E RK G +RPD K V Y+DGK +
Sbjct: 124 DVSATQLMKPTCLMPAPITYAHRLVQRQAEVRKNGTLR-VRPDAKSQVTFSYDDGKIVGI 182
Query: 176 QSIVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADTG 235
++V H ++ L+E +LT T +NPTGRFVIGGP+ D G
Sbjct: 183 DAVVLSTQHSEEIDQKSLQEAVMEEIIKPILPAEWLTSATKFFINPTGRFVIGGPMGDCG 242
Query: 236 LTGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIGY 295
LTGRKI+ D G + GG AFSGKDP+K DRS +Y AR +AK++VA G A+RC +Q+ Y
Sbjct: 243 LTGRKIIVDTTGGMARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGLADRCEIQVSY 302
Query: 296 AFGLTEPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKPIYRQTSVYGHF 355
A GL EP + +ETFGTEK+ E L V++ F L P +I+ LDL PIY++T+ YGHF
Sbjct: 303 AIGLAEPTSIMVETFGTEKVPSEQLTLLVREFFDL-PIGLIQMLDLLHPIYKETAAYGHF 361
Query: 356 GKENLPW 362
G+E+ PW
Sbjct: 362 GREHFPW 368
gb|AAD55092.1|AF179714_1 (AF179714) S-adenosylmethionine synthase [Leishmania donovani]
Length = 392
Score = 309 bits (783), Expect = 3e-83
Identities = 162/366 (44%), Positives = 227/366 (61%), Gaps = 13/366 (3%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+E VTEGHPDK+ DQ++DA+LD + DP+SKV+ E TG+VMV GE+TT++ +D +
Sbjct: 10 SEHVTEGHPDKLCDQVSDAVLDACLAGDPFSKVACESCAKTGMVMVFGEITTKAVLDYQK 69
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE-----GAGDTAIVVGYA 121
+VR+ IKDIG+ + G D ++C V+ +I++QSP+I G+ + GAGD ++ GYA
Sbjct: 70 IVRNTIKDIGFDSADKGLDYESCNVLVAIEQQSPDICQGLGNFDSEDLGAGDQGMMFGYA 129
Query: 122 TKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYE----DGK----PS 173
T E LMP +A + K+ SE R+ G + RPD K V + Y+ +GK P
Sbjct: 130 TDETETLMPLTYELARGLAKKYSELRRSGSLEWARPDAKTQVTVEYDYDTREGKQVLTPK 189
Query: 174 YVQSIVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVAD 233
V ++ HD V+ + + L +T +NP+GRFV GGP D
Sbjct: 190 RVAVVLISAQHDEHVTNDKISVDLMEKVIKAVIPANMLDAETKYWLNPSGRFVRGGPHGD 249
Query: 234 TGLTGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQI 293
GLTGRKI+ D YG G GG AFSGKDP+K DRS +Y AR IAK +VAGG A RCLVQ+
Sbjct: 250 AGLTGRKIIVDTYGGWGAHGGGAFSGKDPSKVDRSAAYAARWIAKSIVAGGLARRCLVQL 309
Query: 294 GYAFGLTEPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKPIYRQTSVYG 353
YA G+ EP++ +ET+GT K L + VK+ F LRP +II+ L+LR+PIY TS +G
Sbjct: 310 AYAIGVAEPLSMHVETYGTGKYDDAKLLEIVKQNFKLRPYDIIQELNLRRPIYYDTSRFG 369
Query: 354 HFGKEN 359
HFG+++
Sbjct: 370 HFGRKD 375
sp|O22338|METK_MUSAC S-ADENOSYLMETHIONINE SYNTHETASE (METHIONINE ADENOSYLTRANSFERASE)
(ADOMET SYNTHETASE) >gi|2305014 (AF004317)
S-adenosyl-L-methionine synthetase homolog [Musa
acuminata]
Length = 393
Score = 308 bits (780), Expect = 6e-83
Identities = 166/368 (45%), Positives = 229/368 (62%), Gaps = 16/368 (4%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESV EGHPDK+ DQ++DA+LD +++DP SKV+ E T +VMV GE+TT+ +D +
Sbjct: 9 SESVNEGHPDKLCDQISDAVLDACLEQDPDSKVACETCTKTNMVMVFGEITTKGNIDYEK 68
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE--------GAGDTAIVV 118
+VR +DIG+T ++G DAD C V+ +I++QSP+IA G+ GAGD +
Sbjct: 69 IVRDTCRDIGFTSEDVGLDADHCKVLVNIEQQSPDIAQGVHGHFTKRPEEIGAGDQGHMF 128
Query: 119 GYATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYEDGK----PSY 174
GYAT E P LMP +A K+ R++E RK G P+LRPDGK V + Y + P
Sbjct: 129 GYATDETPELMPLSHVLATKLGARLTEVRKNGTCPWLRPDGKTQVTVEYRNDHGAMIPVR 188
Query: 175 VQSIVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADT 234
V +++ HD V+ + + +L EKT +NP+GRFVIGGP D
Sbjct: 189 VHTVLISTQHDETVTNDEIAADLKEHVIKPVIPEQYLDEKTIFHLNPSGRFVIGGPHGDA 248
Query: 235 GLTGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIG 294
GLTGRKI+ D YG G GG AFSGKDPTK DRSG+Y+AR AK +VA A RC+VQ+
Sbjct: 249 GLTGRKIIIDTYGGWGAHGGGAFSGKDPTKVDRSGAYVARQAAKSIVASELARRCIVQVS 308
Query: 295 YAFGLTEPVAFDIETFGTEKI-SKEILEDAVKKVFPLRPAEIIEFLDLRKPIYR--QTSV 351
YA G+ EP++ ++T+GT KI KEIL+ VK+ F RP I L L++ YR +T+
Sbjct: 309 YAIGVPEPLSVFVDTYGTGKIPDKEILK-IVKENFDFRPGLITINLGLKRGGYRYLKTAA 367
Query: 352 YGHFGKEN 359
YGHFG+++
Sbjct: 368 YGHFGRDD 375
sp|P93254|METK_MESCR S-ADENOSYLMETHIONINE SYNTHETASE (METHIONINE ADENOSYLTRANSFERASE)
(ADOMET SYNTHETASE) >gi|1724104 (U79767) methionine
adenosyltransferase [Mesembryanthemum crystallinum]
Length = 392
Score = 308 bits (780), Expect = 6e-83
Identities = 165/367 (44%), Positives = 225/367 (60%), Gaps = 14/367 (3%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESV EGHPDK+ DQ++DA+LD + +D SKV+ E T LVMV GE+TT++ VD +
Sbjct: 8 SESVNEGHPDKLCDQISDAVLDACLAQDAESKVACETCTKTNLVMVFGEITTKANVDYEK 67
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE--------GAGDTAIVV 118
+ R ++IG+ ++G DAD C V+ I++QSP+IA G+ GAGD +
Sbjct: 68 IARDTCRNIGFVSDDVGLDADNCKVLVYIEQQSPDIAQGVHGHLTKRPEEIGAGDQGHMF 127
Query: 119 GYATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIY--EDGK--PSY 174
GYAT E P LMP +A K+ R++E RK G P+LRPDGK V + Y E+G P
Sbjct: 128 GYATDETPELMPLSHVLATKLGARLTEVRKNGTCPWLRPDGKTQVTVEYYNENGAMVPVR 187
Query: 175 VQSIVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADT 234
V +++ HD V+ + + +L EKT +NP+GRFVIGGP D
Sbjct: 188 VHTVLISTQHDETVTNDEIAADLKEHVIKPVIPEKYLDEKTIFHLNPSGRFVIGGPHGDA 247
Query: 235 GLTGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIG 294
GLTGRKI+ D YG G GG AFSGKDPTK DRSG+Y+AR AK +VA G A RC+VQI
Sbjct: 248 GLTGRKIIIDTYGGWGAHGGGAFSGKDPTKVDRSGAYIARQAAKSIVAAGLARRCIVQIS 307
Query: 295 YAFGLTEPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRK--PIYRQTSVY 352
YA G+ EP++ ++T+GT KIS + + VK+ F RP I LDL + Y +T+ Y
Sbjct: 308 YAIGVAEPLSVFVDTYGTGKISDKDILKIVKETFDFRPGMIANNLDLLRGGNRYLKTAAY 367
Query: 353 GHFGKEN 359
GHFG+++
Sbjct: 368 GHFGRDD 374
sp|O43938|METK_LEIIN S-ADENOSYLMETHIONINE SYNTHETASE (METHIONINE ADENOSYLTRANSFERASE)
(ADOMET SYNTHETASE) >gi|2665652 (AF031902)
S-adenosylmethionine synthetase [Leishmania infantum]
Length = 392
Score = 307 bits (778), Expect = 1e-82
Identities = 161/366 (43%), Positives = 226/366 (60%), Gaps = 13/366 (3%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+E VTEGHPDK+ DQ++DA+LD + DP+SKV+ E TG+VMV GE+TT++ +D +
Sbjct: 10 SEHVTEGHPDKLCDQVSDAVLDACLAGDPFSKVACESCAKTGMVMVFGEITTKAVLDYQK 69
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE-----GAGDTAIVVGYA 121
+VR+ IKDIG+ + G D ++C V+ +I++QSP+I G+ + GAGD ++ GYA
Sbjct: 70 IVRNTIKDIGFDSADKGLDYESCNVLVAIEQQSPDICQGLGNFDSEDLGAGDQGMMFGYA 129
Query: 122 TKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYE----DGK----PS 173
T E LMP +A + K+ SE R+ G + RPD K V + Y+ +GK P
Sbjct: 130 TDETETLMPLTYELARGLAKKYSELRRSGSLEWARPDAKTQVTVEYDYDTREGKQVLTPK 189
Query: 174 YVQSIVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVAD 233
V ++ HD V+ + + L +T +NP+GRFV GGP D
Sbjct: 190 RVAVVLISAQHDEHVTNDKISVDLMEKVIKAVIPANMLDAETKYWLNPSGRFVRGGPHGD 249
Query: 234 TGLTGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQI 293
GLTGRKI+ D YG G GG AFSGKDP+K DRS +Y AR IAK +VAGG A RCLVQ+
Sbjct: 250 AGLTGRKIIVDTYGGWGAHGGGAFSGKDPSKVDRSAAYAARWIAKSIVAGGLARRCLVQL 309
Query: 294 GYAFGLTEPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKPIYRQTSVYG 353
YA G+ EP++ +ET+GT K + VK+ F LRP +II+ L+LR+PIY TS +G
Sbjct: 310 AYAIGVAEPLSMHVETYGTGKYDDANCLEIVKQNFKLRPYDIIQELNLRRPIYYDTSRFG 369
Query: 354 HFGKEN 359
HFG+++
Sbjct: 370 HFGRKD 375
sp|Q96552|METL_CATRO S-ADENOSYLMETHIONINE SYNTHETASE 2 (METHIONINE ADENOSYLTRANSFERASE
2) (ADOMET SYNTHETASE 2) >gi|1655578|emb|CAA95857|
(Z71272) S-adenosyl-L-methionine synthetase 2
[Catharanthus roseus]
Length = 393
Score = 306 bits (776), Expect = 2e-82
Identities = 165/369 (44%), Positives = 227/369 (60%), Gaps = 17/369 (4%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESV EGHPDK+ DQ++DA+LD + +DP SKV+ E T +VMV GE+TT++ VD +
Sbjct: 8 SESVNEGHPDKLCDQISDAVLDACLAQDPESKVACETCTKTNMVMVFGEITTKAQVDYEK 67
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE--------GAGDTAIVV 118
+VR + IG+ ++G DAD C V+ +I++QSP+IA G+ GAGD +
Sbjct: 68 IVRDTCRAIGFVSDDVGLDADNCKVLVNIEQQSPDIAQGVHGHLTKRPEEIGAGDQGHMF 127
Query: 119 GYATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYEDGK----PSY 174
GYAT E P LMP +A K+ R++E RK G P+LRPDGK V + Y + P
Sbjct: 128 GYATDETPELMPLSHVLATKLGARLTEVRKNGTCPWLRPDGKTQVTVEYYNDNGAMVPIR 187
Query: 175 VQSIVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADT 234
V +++ HD V+ + + +L EKT +NP+GRFVIGGP D
Sbjct: 188 VHTVLISTQHDETVTNDEIAADLKEHVIKPVVPEKYLDEKTIFHLNPSGRFVIGGPHGDA 247
Query: 235 GLTGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIG 294
GLTGRKI+ D YG G GG AFSGKDPTK DRSG+Y+ R AK +VA G A RC+VQ+
Sbjct: 248 GLTGRKIIIDTYGGWGAHGGGAFSGKDPTKVDRSGAYIVRQAAKSIVASGLARRCIVQVS 307
Query: 295 YAFGLTEPVAFDIETFGTEKI-SKEILEDAVKKVFPLRPAEIIEFLDLRK---PIYRQTS 350
YA G+ EP++ ++T+GT KI KEIL+ VK+ F RP I LDL++ + +T+
Sbjct: 308 YAIGVPEPLSVFVDTYGTGKIPDKEILK-IVKENFDFRPGMIAINLDLKRGGNSRFLKTA 366
Query: 351 VYGHFGKEN 359
YGHFG+E+
Sbjct: 367 AYGHFGRED 375
sp|P46611|METK_ORYSA S-ADENOSYLMETHIONINE SYNTHETASE 1 (METHIONINE ADENOSYLTRANSFERASE
1) (ADOMET SYNTHETASE 1) >gi|450549|emb|CAA81481|
(Z26867) S-adenosyl methionine synthetase [Oryza sativa]
Length = 396
Score = 306 bits (775), Expect = 2e-82
Identities = 166/369 (44%), Positives = 229/369 (61%), Gaps = 17/369 (4%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESV EGHPDK+ DQ++DA+LD + +DP SKV+ E T +VMV GE+TT++ VD +
Sbjct: 11 SESVNEGHPDKLCDQVSDAVLDACLAEDPDSKVACETCTKTNMVMVFGEITTKANVDYEK 70
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE--------GAGDTAIVV 118
+VR ++IG+ ++G DAD C V+ +I++QSP+IA G+ GAGD +
Sbjct: 71 IVRETCRNIGFVSADVGLDADHCKVLVNIEQQSPDIAQGVHGHFTKRPEEIGAGDQGHMF 130
Query: 119 GYATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYEDGK----PSY 174
GYAT E P LMP +A K+ R++E RK G +LRPDGK V + Y + P
Sbjct: 131 GYATDETPELMPLSHVLATKLGARLTEVRKNGTCAWLRPDGKTQVTVEYRNESGARVPVR 190
Query: 175 VQSIVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADT 234
V +++ HD V+ + + +L EKT +NP+GRFVIGGP D
Sbjct: 191 VHTVLISTQHDETVTNDEIAADLKEHVIKPVIPEQYLDEKTIFHLNPSGRFVIGGPHGDA 250
Query: 235 GLTGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIG 294
GLTGRKI+ D YG G GG AFSGKDPTK DRSG+Y+AR AK +VA G A RC+VQ+
Sbjct: 251 GLTGRKIIIDTYGGWGAHGGGAFSGKDPTKVDRSGAYVARQAAKSIVASGLARRCIVQVS 310
Query: 295 YAFGLTEPVAFDIETFGTEKI-SKEILEDAVKKVFPLRPAEIIEFLDLRK---PIYRQTS 350
YA G+ EP++ ++T+GT +I KEIL+ VK+ F RP II LDL+K Y +T+
Sbjct: 311 YAIGVPEPLSVFVDTYGTGRIPDKEILK-IVKENFDFRPGMIIINLDLKKGGNGRYLKTA 369
Query: 351 VYGHFGKEN 359
YGHFG+++
Sbjct: 370 AYGHFGRDD 378
sp|Q96551|METK_CATRO S-ADENOSYLMETHIONINE SYNTHETASE 1 (METHIONINE ADENOSYLTRANSFERASE
1) (ADOMET SYNTHETASE 1) >gi|1655576|emb|CAA95856|
(Z71271) S-adenosyl-L-methionine synthetase 1
[Catharanthus roseus]
Length = 393
Score = 305 bits (772), Expect = 5e-82
Identities = 165/369 (44%), Positives = 229/369 (61%), Gaps = 17/369 (4%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESV EGHPDK+ DQ++DA+LD +++DP SKV+ E T +VMV GE+TT++ VD +
Sbjct: 8 SESVNEGHPDKLCDQISDAVLDACLEQDPDSKVACETCTKTNMVMVFGEITTKATVDYEK 67
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE--------GAGDTAIVV 118
+VR + IG+ ++G DAD C V+ +I++QSP+IA G+ GAGD +
Sbjct: 68 IVRDTCRSIGFVSDDVGLDADNCKVLVNIEQQSPDIAQGVHGHLTKRPEEIGAGDQGHMF 127
Query: 119 GYATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIY--EDGK--PSY 174
GYAT E P MP +A K+ R++E RK G P+LRPDGK V + Y E+G P
Sbjct: 128 GYATDETPEFMPLSHVLATKLGARLTEVRKNGTCPWLRPDGKTQVTVEYYNENGAMVPVR 187
Query: 175 VQSIVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADT 234
V ++V HD V+ + + +L E+T +NP+GRFVIGGP D
Sbjct: 188 VHTVVISTQHDETVTNDQIAADLKEHVIKPVIPEKYLDERTIFHLNPSGRFVIGGPHGDA 247
Query: 235 GLTGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIG 294
GLTGRKI+ D YG G GG AFSGKDPTK DRSG+Y+ R AK +VA G A RC+VQ+
Sbjct: 248 GLTGRKIIIDTYGGWGAHGGGAFSGKDPTKVDRSGAYIVRQAAKSIVANGLARRCIVQVS 307
Query: 295 YAFGLTEPVAFDIETFGTEKI-SKEILEDAVKKVFPLRPAEIIEFLDLRK---PIYRQTS 350
YA G+ EP++ ++T+GT KI KEIL+ VK+ F RP I LDL++ + +T+
Sbjct: 308 YAIGVPEPLSVFVDTYGTGKIPDKEILK-IVKENFDFRPGMIAINLDLKRGGSGRFLKTA 366
Query: 351 VYGHFGKEN 359
YGHFG+++
Sbjct: 367 AYGHFGRDD 375
sp|P50301|METK_ACTCH S-ADENOSYLMETHIONINE SYNTHETASE 1 (METHIONINE ADENOSYLTRANSFERASE
1) (ADOMET SYNTHETASE 1) >gi|726030 (U17240)
S-adenosylmethionine synthetase [Actinidia chinensis]
Length = 390
Score = 304 bits (771), Expect = 7e-82
Identities = 161/368 (43%), Positives = 227/368 (60%), Gaps = 15/368 (4%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESV EGHPDK+ DQ++DA+LD +K+DP SKV+ E T +VMV GE+TT++ V+ +
Sbjct: 8 SESVNEGHPDKLCDQVSDAILDACLKQDPESKVACESCTKTNMVMVFGEITTKAQVNYEK 67
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE--------GAGDTAIVV 118
+VR + IG+T P++G DAD C V+ +I++QSP+IA G+ GAGD +
Sbjct: 68 IVRDTCRGIGFTSPDVGLDADHCKVLVNIEQQSPDIAQGVHGHLTKKPEEIGAGDQGHMF 127
Query: 119 GYATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIY--EDGK--PSY 174
GYAT E P LMP +A K+ +++E RK P+LRPDGK V + Y E G P
Sbjct: 128 GYATDETPELMPLTHVLATKLGAKLTEVRKNSTCPWLRPDGKTQVTVEYRNEGGAMVPIR 187
Query: 175 VQSIVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADT 234
V +++ HD V+ + + +L + T +NP+GRFVIGGP D
Sbjct: 188 VHTVLISTQHDETVTNDQIANDLKKHVIKPVVPAQYLDDNTIFHLNPSGRFVIGGPHGDA 247
Query: 235 GLTGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIG 294
GLTGRKI+ D YG G GG AFSGKDPTK DRSG+Y+ R AK VVA G A RCLVQ+
Sbjct: 248 GLTGRKIIIDTYGGWGAHGGGAFSGKDPTKVDRSGAYIVRQAAKSVVASGLARRCLVQVS 307
Query: 295 YAFGLTEPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKP---IYRQTSV 351
YA G+ EP++ ++T+ T KI+ + + +K+ F RP I LDL++ Y++T+
Sbjct: 308 YAIGVAEPLSVFVDTYKTGKIADKDILALIKENFDFRPGMIAINLDLKRGGNLRYQKTAA 367
Query: 352 YGHFGKEN 359
YGHFG+++
Sbjct: 368 YGHFGRDD 375
sp|P47916|METK_POPDE S-ADENOSYLMETHIONINE SYNTHETASE (METHIONINE ADENOSYLTRANSFERASE)
(ADOMET SYNTHETASE) >gi|497900 (M73430) S-adenosyl
methionine synthetase [Populus deltoides]
Length = 395
Score = 303 bits (769), Expect = 1e-81
Identities = 165/369 (44%), Positives = 231/369 (61%), Gaps = 17/369 (4%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESV EGHPDK+ DQ++DA+LD + +DP SKV+ E T +VMV GE+TT++ VD +
Sbjct: 9 SESVNEGHPDKLCDQISDAVLDACLAQDPDSKVACETCTKTNMVMVFGEITTKADVDYEK 68
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE--------GAGDTAIVV 118
+VR ++IG+T ++G DAD C V+ +I++QSP+IA G+ GAGD +
Sbjct: 69 IVRDTCRNIGFTSADVGLDADNCKVLVNIEQQSPDIAQGVHGHFSKRPEEIGAGDQGHMF 128
Query: 119 GYATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIY--EDGK--PSY 174
GYAT E P LMP +A K+ R++E RK G +LRPDGK V + Y E+G P
Sbjct: 129 GYATDETPELMPLSHVLATKLGARLTEVRKNGTCAWLRPDGKTQVTVEYYNENGAMVPVR 188
Query: 175 VQSIVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADT 234
V +++ HD V+ + + +L EKT +NP+GRFVIGGP ++
Sbjct: 189 VHTVLISTQHDETVTNDEIAADLKEHVIKPVIPEKYLDEKTIFHLNPSGRFVIGGPHGES 248
Query: 235 GLTGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIG 294
GLTGRKI+ D YG G GG AFSGKDPTK DRSG+Y+ R AK +VA G A RC+VQ+
Sbjct: 249 GLTGRKIIIDTYGGWGAHGGGAFSGKDPTKVDRSGAYIVRQAAKSIVASGLARRCIVQVS 308
Query: 295 YAFGLTEPVAFDIETFGTEKI-SKEILEDAVKKVFPLRPAEIIEFLDLRK---PIYRQTS 350
YA G+ EP++ ++T+GT KI KEIL+ VK+ F RP I LDL++ + +T+
Sbjct: 309 YAIGVPEPLSVFVDTYGTGKIPDKEILQ-IVKERFDFRPGMISINLDLKRGGNSRFLKTA 367
Query: 351 VYGHFGKEN 359
YGHFG+++
Sbjct: 368 AYGHFGRDD 376
sp|P43281|METL_LYCES S-ADENOSYLMETHIONINE SYNTHETASE 2 (METHIONINE ADENOSYLTRANSFERASE
2) (ADOMET SYNTHETASE 2) >gi|481566|pir||S38875
methionine adenosyltransferase (EC 2.5.1.6) - tomato
>gi|429106|emb|CAA80866| (Z24742)
S-adenosyl-L-methionine synthetase [Lycopersicon
esculentum]
Length = 393
Score = 303 bits (769), Expect = 1e-81
Identities = 159/368 (43%), Positives = 224/368 (60%), Gaps = 15/368 (4%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESV EGHPDK+ DQ++DA+LD + +DP SKV+ E T LVMV GE+TT++ +D +
Sbjct: 8 SESVNEGHPDKLCDQVSDAVLDACLAQDPESKVACETCTKTNLVMVFGEITTKANIDYEK 67
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE--------GAGDTAIVV 118
+VR ++IG+ P++G DAD C V+ +I++QSP+IA G+ GAGD +
Sbjct: 68 IVRDTCREIGFVSPDVGLDADNCRVLVNIEQQSPDIAQGVHGHLTKRPEEIGAGDQGHMF 127
Query: 119 GYATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYEDGK----PSY 174
GYAT E P LMP +A K+ R++E RK G +LRPDGK V + Y + P
Sbjct: 128 GYATDETPELMPLSHVLATKLGARLTEVRKNGTCSWLRPDGKTQVTVEYHNDNGAMVPLR 187
Query: 175 VQSIVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADT 234
V +++ HD V+ + + +L E T +NP+GRFVIGGP D
Sbjct: 188 VHTVLISTQHDETVTNDEIARDLKEHVIKPVIPEKYLDENTIFHLNPSGRFVIGGPHGDA 247
Query: 235 GLTGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIG 294
GLTGRKI+ D YG G GG AFSGKDPTK DRSG+Y+ R AK +VA G A RC+VQ+
Sbjct: 248 GLTGRKIIIDTYGGWGAHGGGAFSGKDPTKVDRSGAYIVRQAAKSIVANGLARRCIVQVS 307
Query: 295 YAFGLTEPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRK---PIYRQTSV 351
YA G+ EP++ ++T+GT KI + + + VK+ F RP I LDL + + +T+
Sbjct: 308 YAIGVPEPLSVFVDTYGTGKIPDKEILNIVKENFDFRPGMISINLDLLRGGNGRFLKTAA 367
Query: 352 YGHFGKEN 359
YGHFG+++
Sbjct: 368 YGHFGRDD 375
gb|AAD48485.1|AF170798_1 (AF170798) S-adenosyl-L-methionine synthetase [Petunia x hybrida]
Length = 393
Score = 303 bits (768), Expect = 1e-81
Identities = 166/369 (44%), Positives = 228/369 (60%), Gaps = 17/369 (4%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESV EGHPDK+ DQ++DA+LD +++DP SKV+ E T LVMV GE+TT++ VD +
Sbjct: 8 SESVNEGHPDKLCDQISDAVLDACLEQDPESKVACETCTKTNLVMVFGEITTKANVDYEK 67
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE--------GAGDTAIVV 118
+VR ++IG+ ++G DAD C V+ I++QSP+IA G+ GAGD +
Sbjct: 68 IVRDTCRNIGFISDDVGLDADNCKVLVYIEQQSPDIAQGVHGHLTKQPEEIGAGDQGHMF 127
Query: 119 GYATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIY--EDGK--PSY 174
GYAT E P MP +A K+ R++E RK G P+LRPDGK V + Y E+G P
Sbjct: 128 GYATDETPEFMPLSHVLATKLGARLTEVRKNGTCPWLRPDGKTQVTVEYYNENGAMVPVR 187
Query: 175 VQSIVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADT 234
V +++ HD V+ + + +L EKT +NP+GRFVIGGP D
Sbjct: 188 VHTVLISTQHDETVTNDEIAHDLKEHVIKPVIPEKYLDEKTIFHLNPSGRFVIGGPHGDA 247
Query: 235 GLTGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIG 294
GLTGRKI+ D YG G GG AFSGKDPTK DRSG+Y+ R AK VVA G A RC+VQ+
Sbjct: 248 GLTGRKIIIDTYGGWGAHGGGAFSGKDPTKVDRSGAYIVRQAAKSVVANGLARRCIVQVS 307
Query: 295 YAFGLTEPVAFDIETFGTEKI-SKEILEDAVKKVFPLRPAEIIEFLDLRK---PIYRQTS 350
YA G+ EP++ ++T+GT I KEIL+ VK+ F RP I LDL++ + +T+
Sbjct: 308 YAIGVPEPLSVFVDTYGTGMIPDKEILK-IVKENFDFRPGMIAINLDLKRGGNGRFLKTA 366
Query: 351 VYGHFGKEN 359
YGHFG+++
Sbjct: 367 AYGHFGRDD 375
sp|P50299|METK_HORVU S-ADENOSYLMETHIONINE SYNTHETASE 1 (METHIONINE ADENOSYLTRANSFERASE
1) (ADOMET SYNTHETASE 1) >gi|960357|dbj|BAA09895|
(D63835) S-adenosylmethionine synthetase [Hordeum
vulgare]
Length = 394
Score = 302 bits (764), Expect = 4e-81
Identities = 163/367 (44%), Positives = 224/367 (60%), Gaps = 14/367 (3%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESV EGHPDK+ DQ++DA+LD + +DP SKV+ E T +VMV GE+TT++ VD +
Sbjct: 10 SESVNEGHPDKLCDQVSDAVLDACLAQDPDSKVACETCTKTNMVMVFGEITTKATVDYEK 69
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE--------GAGDTAIVV 118
+VR +DIG+ ++G DAD C V+ +I++QSP+IA G+ GAGD I+
Sbjct: 70 IVRDTCRDIGFISDDVGLDADHCKVLVNIEQQSPDIAQGVHGHFTKRPEEVGAGDQGIMF 129
Query: 119 GYATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIY--EDGK--PSY 174
GYAT E P LMP +A K+ R++E RK G +LRPDGK V + Y E G P
Sbjct: 130 GYATDETPELMPLTHMLATKLGARLTEVRKNGTCAWLRPDGKTQVTIEYLNEGGAMVPVR 189
Query: 175 VQSIVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADT 234
V +++ HD V+ + + +L E T +NP+GRFVIGGP D
Sbjct: 190 VHTVLISTQHDETVTNDEIAADLKEHVIKPVIPGKYLDENTIFHLNPSGRFVIGGPHGDA 249
Query: 235 GLTGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIG 294
GLT RKI+ D YG G GG AFSGKDPTK DRSG+Y+AR AK ++A G A RC+VQI
Sbjct: 250 GLTARKIIIDTYGGWGAHGGGAFSGKDPTKVDRSGAYIARQAAKSIIASGLARRCIVQIS 309
Query: 295 YAFGLTEPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRKPIYR--QTSVY 352
YA G+ EP++ ++++GT KI + VK+ F RP I LDL+K R +T+ Y
Sbjct: 310 YAIGVPEPLSVFVDSYGTGKIPDREILKLVKENFDFRPGMITINLDLKKGGNRFIKTAAY 369
Query: 353 GHFGKEN 359
GHFG+++
Sbjct: 370 GHFGRDD 376
sp|P24260|METL_DIACA S-ADENOSYLMETHIONINE SYNTHETASE 2 (METHIONINE ADENOSYLTRANSFERASE
2) (ADOMET SYNTHETASE 2) >gi|304637 (M61882)
S-adenosylmethionine synthetase [Dianthus caryophyllus]
>gi|228314|prf||1802406A Met(S-adenosyl) synthetase
[Dianthus caryophyllus]
Length = 396
Score = 302 bits (764), Expect = 4e-81
Identities = 164/367 (44%), Positives = 222/367 (59%), Gaps = 14/367 (3%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESV EGHPDK+ DQ++DA+LD + +D SKV+ E T LVMV GE+TT++ VD +
Sbjct: 12 SESVNEGHPDKLCDQISDAVLDACLAQDAESKVACETCTKTNLVMVFGEITTKANVDYEK 71
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE--------GAGDTAIVV 118
+V ++IG+ P++G DAD C V+ I++QSP+IA G+ GAGD +
Sbjct: 72 IVADTCREIGFVSPDVGLDADNCKVLVYIEQQSPDIAQGVHGHLTKRPEDIGAGDQGHMF 131
Query: 119 GYATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIY--EDGK--PSY 174
GYAT E P LMP +A K+ R++E RK G +LRPDGK V + Y E+G P
Sbjct: 132 GYATDETPELMPLSHVLATKLGARLTEVRKNGTCAWLRPDGKTQVTVEYYNENGAMVPIR 191
Query: 175 VQSIVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADT 234
V +++ HD V+ + + +L E T +NP+GRFVIGGP D
Sbjct: 192 VHTVLISTQHDETVTNDEIAADLKEHVIKPVIPEKYLDENTIFHLNPSGRFVIGGPHGDA 251
Query: 235 GLTGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIG 294
GLTGRKI+ D YG G GG AFS KDPTK DRSG+Y+AR AK +VA G A RC+VQI
Sbjct: 252 GLTGRKIIIDTYGGWGAHGGGAFSRKDPTKVDRSGAYIARQAAKSIVASGLARRCIVQIS 311
Query: 295 YAFGLTEPVAFDIETFGTEKISKEILEDAVKKVFPLRPAEIIEFLDLRK--PIYRQTSVY 352
YA G+ EP++ ++T+GT KI + VK+ F RP I LDL+K Y +T+ Y
Sbjct: 312 YAIGVPEPLSVFVDTYGTGKIHDREILKIVKENFDFRPGMIAIALDLKKGGNRYLKTAAY 371
Query: 353 GHFGKEN 359
GHFG+E+
Sbjct: 372 GHFGRED 378
sp|P93438|METL_ORYSA S-ADENOSYLMETHIONINE SYNTHETASE 2 (METHIONINE ADENOSYLTRANSFERASE
2) (ADOMET SYNTHETASE 2) >gi|1778821 (U82833)
S-adenosyl-L-methionine synthetase [Oryza sativa]
Length = 394
Score = 300 bits (761), Expect = 1e-80
Identities = 164/368 (44%), Positives = 227/368 (61%), Gaps = 16/368 (4%)
Query: 7 AESVTEGHPDKIADQLADALLDEFIKKDPYSKVSLEIMVTTGLVMVGGELTTESYVDIPR 66
+ESV EGHPDK+ DQ++DA+LD + +DP SKV+ E T +VMV GE+TT++ VD +
Sbjct: 10 SESVNEGHPDKLCDQVSDAVLDACLAQDPDSKVACETCTKTNMVMVFGEITTKATVDYEK 69
Query: 67 VVRSVIKDIGYTRPELGFDADTCAVVQSIDEQSPEIALGISSE--------GAGDTAIVV 118
+VR + IG+ ++G DAD C V+ +I++QSP+IA G+ GAGD +
Sbjct: 70 IVRDTCRGIGFVSDDVGLDADRCKVLVNIEQQSPDIAQGVHGHFTKRPEEIGAGDQGHMF 129
Query: 119 GYATKEAPNLMPWPITIAHKITKRISEYRKIGKFPFLRPDGKVLVAMIYEDGK----PSY 174
GYAT E P LMP +A K+ R++E RK G +LRPDGK V + Y + P
Sbjct: 130 GYATDETPELMPLSHVLATKLGARLTEVRKNGTCAWLRPDGKTQVTVEYLNDAGAMVPVR 189
Query: 175 VQSIVAYVHHDPDVSINHLRELXXXXXXXXXXXXXFLTEKTSIKVNPTGRFVIGGPVADT 234
V +++ HD V+ + + +L EKT +NP+GRFVIGGP D
Sbjct: 190 VHTVLISTQHDETVTNDEIAADLKEHVIKPVIPDKYLDEKTIFHLNPSGRFVIGGPHGDA 249
Query: 235 GLTGRKIVSDAYGDIGLSGGSAFSGKDPTKTDRSGSYLARMIAKHVVAGGWAERCLVQIG 294
GLTGRKI+ D YG G GG AFSGKDPTK DRSG+Y+AR AK +VA G A RC+VQ+
Sbjct: 250 GLTGRKIIIDTYGGWGAHGGGAFSGKDPTKVDRSGAYIARQAAKSIVASGLARRCIVQVS 309
Query: 295 YAFGLTEPVAFDIETFGTEKI-SKEILEDAVKKVFPLRPAEIIEFLDLRKPIYR--QTSV 351
YA G+ EP++ ++++GT KI KEIL+ VK+ F RP + LDL++ R +T+
Sbjct: 310 YAIGVPEPLSVFVDSYGTGKIPDKEILK-IVKENFDFRPGMMTINLDLKRGGNRFIKTAA 368
Query: 352 YGHFGKEN 359
YGHFG+E+
Sbjct: 369 YGHFGRED 376
Database: Non-redundant GenBank CDS
translations+PDB+SwissProt+SPupdate+PIR
Posted date: Jan 12, 2000 2:26 PM
Number of letters in database: 136,724,657
Number of sequences in database: 444,417
Lambda K H
0.318 0.139 0.403
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 95839812
Number of Sequences: 444417
Number of extensions: 4035914
Number of successful extensions: 10737
Number of sequences better than 10.0: 94
Number of HSP's better than 10.0 without gapping: 91
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 10395
Number of HSP's gapped (non-prelim): 96
length of query: 376
length of database: 136,724,657
effective HSP length: 55
effective length of query: 321
effective length of database: 112,281,722
effective search space: 36042432762
effective search space used: 36042432762
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 71 (32.1 bits)
