Score E
Sequences producing significant alignments: (bits) Value
gi|2983635 (AE000727) carbamoyl-phosphate synthase large su... 1041 0.0
gi|2649305 (AE001016) carbamoyl-phosphate synthase, large (... 616 e-175
pir||D64472 carbamoyl-phosphate synthase, pyrimidine-specif... 606 e-172
gb|AAF16526.1|AF191301_2 (AF191301) ADP-forming, carbamate-... 567 e-161
gi|2622097 (AE000872) carbamoyl-phosphate synthase, large s... 566 e-160
gi|1750387 (U81259) carbamoylphosphate synthetase large sub... 560 e-159
pdb|1CE8|A Chain A, Carbamoyl Phosphate Synthetase From Esc... 554 e-157
sp|P14846|CARB_SALTY CARBAMOYL-PHOSPHATE SYNTHASE LARGE CHA... 554 e-157
sp|P00968|CARB_ECOLI CARBAMOYL-PHOSPHATE SYNTHASE LARGE CHA... 554 e-157
dbj|BAA10403| (D64002) carbamoyl-phosphate synthase, pyrimi... 542 e-153
gb|AAD35642.1|AE001730_10 (AE001730) carbamoyl-phosphate sy... 533 e-150
gi|1477480 (U40341) carbamoyl phosphate synthetase large ch... 522 e-147
gi|3820584 (AF086791) carbamoylphosphate synthetase large s... 521 e-147
emb|CAB44435.1| (AJ242913) carbamoylphosphate synthase (lar... 514 e-145
pdb|1A9X|A Chain A, Carbamoyl Phosphate Synthetase: Caught ... 513 e-144
gi|4155424 (AE001514) CARBAMOYL-PHOSPHATE SYNTHASE LARGE CH... 495 e-139
gb|AAD07963.1| (AE000601) carbamoyl-phosphate synthase (glu... 495 e-139
gi|533532 (U11295) carbamoyl phosphate synthetase (glutamin... 480 e-134
sp|P25994|CARB_BACSU CARBAMOYL-PHOSPHATE SYNTHASE, PYRIMIDI... 471 e-132
sp|P46537|CARB_BACCL CARBAMOYL-PHOSPHATE SYNTHASE, PYRIMIDI... 463 e-129
emb|CAA05020| (AJ001805) carbomylphosphate synthetase large... 456 e-127
sp|P77886|CARB_LACPL CARBAMOYL-PHOSPHATE SYNTHASE, PYRIMIDI... 446 e-124
emb|CAA72256| (Y11467) carbamoyl-phosphate synthase (glutam... 441 e-123
emb|CAA03928| (AJ000109) carbamoylphosphate synthetase [Lac... 439 e-122
gb|AAF10248.1|AE001924_1 (AE001924) carbamoyl-phosphate syn... 416 e-115
sp|P13258|CARB_METBA CARBAMOYL-PHOSPHATE SYNTHASE LARGE CHA... 415 e-115
pir||A28180 carbamoyl-phosphate synthase (glutamine-hydroly... 410 e-113
pir||A49930 carB protein homolog - Mycobacterium bovis (str... 400 e-110
pir||S53602 carbamoyl-phosphate synthase (glutamine-hydroly... 374 e-102
gi|530209 (L31362) carbamyl phosphate synthetase III [Squal... 374 e-102
sp|P07756|CPSM_RAT CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], ... 371 e-102
sp|P31327|CPSM_HUMAN CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA]... 370 e-101
gb|AAD51318.2| (AF169248) acetylglutamate-activated carbamo... 369 e-101
gi|2245664 (AF006491) carbamoyl-phosphate synthetase III; C... 369 e-101
gi|4185560 (AF112473) PyrABCN [Emericella nidulans] 367 e-100
sp|Q91293|CPSM_RANCA CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA]... 366 e-100
gi|1518088 (U65893) carbamoyl-phosphate synthetase III [Onc... 365 e-100
ref|NP_012405.1|URA2| carbamoyl-phophate synthetase, aspart... 361 6e-99
emb|CAA60825| (X87371) carbamyl phosphate synthetase [Sacch... 361 6e-99
gi|173146 (M27174) carbamyl phosphate synthetase [Saccharom... 361 6e-99
gb|AAD43968.1|AF119250_1 (AF119250) carbamoyl-phosphate syn... 358 6e-98
ref|NP_001866.1|| carbamoyl-phosphate synthetase 1, mitocho... 357 1e-97
sp|Q09794|PYR1_SCHPO URA1 PROTEIN [INCLUDES: GLUTAMINE-DEPE... 357 1e-97
pir||S65074 pyrimidine synthesis protein URA1 - fission yea... 350 1e-95
emb|CAA91059.1| (Z54284) similar to glutamine-dependent car... 341 9e-93
sp|Q91437|PYR1_SQUAC CAD PROTEIN [INCLUDES: GLUTAMINE-DEPEN... 340 2e-92
ref|NP_004332.1|| carbamoyl-phosphate synthetase 2, asparta... 334 9e-91
sp|P08955|PYR1_MESAU CAD PROTEIN [INCLUDES: GLUTAMINE-DEPEN... 334 9e-91
gi|191333 (J05503) carbamoyl-phosphate synthetase (E.C.6.3.... 334 9e-91
gb|AAD18071| (AF129814) carbamyl phosphate synthetase II; C... 330 2e-89
gi|3912935 (U43091) carbamoylphosphate synthetase heavy sub... 329 3e-89
sp|P20054|PYR1_DICDI PROTEIN PYR1-3 [INCLUDES: GLUTAMINE-DE... 328 9e-89
pir||S23738 pyr1-3 protein - slime mold (Dictyostelium disc... 325 5e-88
emb|CAB56843.1| (X99978) carbamoyl-phosphate synthase large... 325 6e-88
sp|P46056|CARB_TRICU CARBAMOYL-PHOSPHATE SYNTHASE, ARGININE... 324 1e-87
emb|CAA22122| (AL033534) carbamoyl-phosphate synthase [Schi... 323 3e-87
sp|P18185|CARY_BACSU CARBAMOYL-PHOSPHATE SYNTHASE, ARGININE... 317 1e-85
sp|Q59969|CARB_SULSO CARBAMOYL-PHOSPHATE SYNTHASE LARGE CHA... 308 7e-83
gi|476024 (L32150) carbamoyl phosphate synthetase II [Plasm... 305 7e-82
ref|NP_012643.1|CPA2| carbamyl phosphate synthetase; Cpa2p ... 301 8e-81
dbj|BAA21087| (AB005062) carbamyl phosphate synthase [Leish... 281 8e-75
dbj|BAA21088| (AB005063) carbamyl phosphate synthase [Trypa... 274 1e-72
gi|619743 (U18792) glutamine-dependent carbamoyl phosphate ... 267 2e-70
gi|2984303 (AE000772) carbamoyl-phosphate synthase large su... 259 3e-68
gi|2826402 (U67577) carbamoyl-phosphate synthase, medium su... 256 3e-67
pir||A64472 carbamoyl-phosphate synthase, large chain (EC 6... 256 3e-67
sp|P05990|PYR1_DROME CAD PROTEIN (RUDIMENTARY PROTEIN) [INC... 225 6e-58
emb|CAA28502| (X04813) CAD protein (AA 1 - 2236) [Drosophil... 225 6e-58
emb|CAB07850.1| (Z93780) carbamoyl phosphate synthetase III... 209 4e-53
gi|2622098 (AE000872) carbamoyl-phosphate synthase, large s... 153 4e-36
gi|173144 (J04711) carbamylase phosphate synthetase-asparta... 108 2e-22
pir||QZDOP3 pyrimidine synthesis protein PYR1-3 - slime mol... 101 2e-20
emb|CAA32782| (X14634) PYR1-3B multifunctional enzyme (1014... 99 1e-19
gi|191335 (M21927) carbamyl phosphate synthetase II [Mesocr... 97 3e-19
emb|CAA32781| (X14633) PYR1-3A multifunctional enzyme (AA 1... 91 2e-17
emb|CAB09721| (Z97025) pyruvate carboxylase [Bacillus subti... 80 4e-14
emb|CAB13359| (Z99111) pyruvate carboxylase [Bacillus subti... 79 1e-13
emb|CAA15061| (AJ235272) PROPIONYL-COA CARBOXYLASE ALPHA CH... 76 9e-13
sp|Q58626|PYCA_METJA PYRUVATE CARBOXYLASE SUBUNIT A (PYRUVI... 73 7e-12
sp|O27939|PYCA_METTH PYRUVATE CARBOXYLASE SUBUNIT A (PYRUVI... 71 2e-11
gi|2983981 (AE000749) biotin carboxylase [Aquifex aeolicus] 71 3e-11
ref|NP_011453.1|PYC1| pyruvate carboxylase; Pyc1p >gi|17099... 68 1e-10
gi|172102 (J03889) pyruvate carboxylase (EC 6.4.1.1) [Sacch... 68 1e-10
sp|P37798|ACCC_PSEAE BIOTIN CARBOXYLASE (A SUBUNIT OF ACETY... 68 2e-10
gi|3806120 (AF097728) pyruvate carboxylase [Aspergillus ter... 67 3e-10
ref|NP_009777.1|PYC2| pyruvate carboxylase; Pyc2p >gi|58576... 67 3e-10
sp|P39771|PURT_BACSU PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSF... 66 7e-10
dbj|BAA10298| (D64001) biotin carboxylase [Synechocystis sp.] 66 7e-10
ref|NP_000273.1|| Propionyl-Coenzyme A carboxylase, alpha p... 66 7e-10
pir||S47267 5'-phosphoribosyl-1-glycinamide transformylase ... 65 2e-09
gb|AAD34740.1| (AF132152) unknown [Drosophila melanogaster] 64 2e-09
gi|2983860 (AE000742) biotin carboxylase [Aquifex aeolicus] 64 2e-09
sp|Q58881|PURT_METJA PROBABLE PHOSPHORIBOSYLGLYCINAMIDE FOR... 64 2e-09
gi|550486 (L36530) pyruvate carboxylase [Aedes aegypti] 64 2e-09
gi|145896 (M79446) biotin carboxylase [Escherichia coli] 64 2e-09
sp|P24182|ACCC_ECOLI BIOTIN CARBOXYLASE (A SUBUNIT OF ACETY... 64 2e-09
gi|2323335 (AF014386) carbamoyl-phosphate synthetase II [On... 64 3e-09
gi|3219361 (AF068249) biotin carboxylase precursor [Glycine... 63 5e-09
dbj|BAA12569| (D84432) YqhX [Bacillus subtilis] >gi|2634868... 63 5e-09
emb|CAA42544| (X59890) pyruvate carboxylase [Saccharomyces ... 63 5e-09
gi|2983635 (AE000727) carbamoyl-phosphate synthase large subunit [Aquifex
aeolicus]
Length = 537
Score = 1041 bits (2663), Expect = 0.0
Identities = 527/537 (98%), Positives = 527/537 (98%)
Query: 1 MSKKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLY 60
MSKKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLY
Sbjct: 1 MSKKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLY 60
Query: 61 FEPIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDREL 120
FEPIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDREL
Sbjct: 61 FEPIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDREL 120
Query: 121 FRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXX 180
FRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYD
Sbjct: 121 FRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDEEELKEY 180
Query: 181 XXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIP 240
AVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIP
Sbjct: 181 LEEAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIP 240
Query: 241 PYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSI 300
PYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSI
Sbjct: 241 PYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSI 300
Query: 301 GYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFP 360
GYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFP
Sbjct: 301 GYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFP 360
Query: 361 EVDPILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILELA 420
EVDPILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILELA
Sbjct: 361 EVDPILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILELA 420
Query: 421 KEFEKLGFGIYATSGTYKFLKEHGVNAKRVLKVSEGRPNVVDMIINGEIHLVINTPSGKR 480
KEFEKLGFGIYATSGTYKFLKEHGVNAKRVLKVSEGRPNVVDMIINGEIHLVINTPSGKR
Sbjct: 421 KEFEKLGFGIYATSGTYKFLKEHGVNAKRVLKVSEGRPNVVDMIINGEIHLVINTPSGKR 480
Query: 481 EKSDAYYIRRACVQFNVPYYTTMRAGYAVLEAIKSIKKLKEEGKGLSVHSLQEIYNI 537
EKSDAYYIRRACVQFNVPYYTTMRAGYAVLEAIKSIKKLKEEGKGLSVHSLQEIYNI
Sbjct: 481 EKSDAYYIRRACVQFNVPYYTTMRAGYAVLEAIKSIKKLKEEGKGLSVHSLQEIYNI 537
gi|2649305 (AE001016) carbamoyl-phosphate synthase, large (or ammonia) subunit
(carB) [Archaeoglobus fulgidus]
Length = 1076
Score = 616 bits (1571), Expect = e-175
Identities = 312/534 (58%), Positives = 404/534 (75%), Gaps = 22/534 (4%)
Query: 3 KKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFE 62
KKV+ILG+GPNRIGQGIEFDY CVHAVFSL++EGY +MVNCNPETVSTDYDT+D+LYFE
Sbjct: 561 KKVMILGAGPNRIGQGIEFDYCCVHAVFSLKDEGYETIMVNCNPETVSTDYDTSDRLYFE 620
Query: 63 PIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFR 122
PI E VM+I E E+PEGVI+QFGGQTPL +A L+ +G +ILGT +SID AEDRE F
Sbjct: 621 PITHEDVMNIYENEQPEGVIVQFGGQTPLNIARELEDSGARILGTSVDSIDIAEDRERFA 680
Query: 123 ELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXX 182
EL+ L + QP +G A + EEA +IA++IGFPVLVRPSYVLGGRAM IVYD
Sbjct: 681 ELLERLNIPQPENGIAHSLEEAKEIARKIGFPVLVRPSYVLGGRAMEIVYDEETLERYIT 740
Query: 183 XAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPY 242
A+ VS E+P+LIDKFL+++IE++VDA+ DG++V+IG +MEHIEEAGVHSGDSA +PP
Sbjct: 741 EALEVSPEKPILIDKFLEDAIEVEVDALCDGEEVVIGGIMEHIEEAGVHSGDSACVLPPV 800
Query: 243 SLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGY 302
SL + + + + TRKLA+AL V GLIN+QYAV++ +VYVLE NPRASRTVPFVSK+ G
Sbjct: 801 SLDEVTINTIVDYTRKLALALNVVGLINIQYAVKDGKVYVLEANPRASRTVPFVSKATGI 860
Query: 303 PLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEV 362
PLAKIA K+ +GK LRE+ V E+L + K +VKE VFP+ + P V
Sbjct: 861 PLAKIAAKLMMGKKLREL--GVKEKL--------------KLKHVAVKEAVFPFIKLPGV 904
Query: 363 DPILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDK-PKILELAK 421
DP+LGPEMKSTGEVMGID +FGLAYYKA+L+AG +LP KG +FISV +DK ++L LA+
Sbjct: 905 DPVLGPEMKSTGEVMGIDYDFGLAYYKAELAAGMKLPLKGTVFISVRRKDKNDRLLYLAR 964
Query: 422 EFEKLGFGIYATSGTYKFLKEHGVNAKRVLKVSEGRPNVVDMIINGEIHLVINTPSGKRE 481
+F++LGF I AT GT FL ++G+ A +LK+S+GRPN++D I+NG++ L+INTPSGKR
Sbjct: 965 KFKELGFRIIATDGTRDFLVQNGIEADLILKISQGRPNILDAIVNGQVDLIINTPSGKRG 1024
Query: 482 KSDAYYIRRACVQFNVPYYTTMRAGYAVLEAIKSIKKLKEEGKGLSVHSLQEIY 535
+++ Y IRRA V + V + TT+ A + AI+++K K + V S+QE +
Sbjct: 1025 RTEGYMIRRAAVDYGVAHITTLAGAMAAVRAIEAVKSRK-----MVVKSIQEYH 1073
Score = 258 bits (652), Expect = 9e-68
Identities = 167/474 (35%), Positives = 263/474 (55%), Gaps = 25/474 (5%)
Query: 3 KKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFE 62
+K++++GSGP IGQ EFDY+ A +L+EEGY V+VN NP T+ TD + AD++Y E
Sbjct: 8 RKIMVIGSGPIVIGQAAEFDYSGSQACKALREEGYEVVLVNSNPATIMTDPEMADRVYIE 67
Query: 63 PIVFEHVMDIIEREKPEGVILQFGGQTPLKLALP------LQKNGVKILGTKPESIDKAE 116
P+ E V IIERE P+ ++ GGQT L LA+ L K GV+++G K E+I KAE
Sbjct: 68 PLDAEIVAKIIERETPDALLPTLGGQTALNLAVQLTEMGVLDKYGVELIGAKFEAIKKAE 127
Query: 117 DRELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXX 176
DRELF+E + ++GL P S A EAL IA EIG+PV+VRP++ LGG I Y+
Sbjct: 128 DRELFKEAMRKIGLDVPKSDVAHDVSEALAIADEIGYPVVVRPAFTLGGTGGGIAYNREE 187
Query: 177 XXXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKD-VLIGAVMEHIEEAGVHSGDS 235
+ +S VLI++ + E +++ + D D V+I +E+ + GVH+GDS
Sbjct: 188 LREIAERGIKMSMINQVLIEEGVLGWKEFELEVMRDLADNVVIICSIENFDPMGVHTGDS 247
Query: 236 ATSIPPYSLSKEIVEEVKEQTRKLAVALEVK-GLINVQYAV--QNNEVYVLEVNPRASRT 292
T P +L+ + +++ K+ + V+ G N+Q+AV +N V +E+NPR SR+
Sbjct: 248 ITVAPAQTLTDVEYQYLRDAAIKIIREIGVETGGSNIQFAVHPENGRVVAIEMNPRVSRS 307
Query: 293 VPFVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEV 352
SK+ G+P+AKIA K+A+G +L EI ++ + + F P + VK
Sbjct: 308 SALASKATGFPIAKIAAKLAVGYTLDEIPNDITKET-------PASFEPTIDYVV-VKIP 359
Query: 353 VFPWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRD 412
F + +FP + +LG +MKS GEVM + + F A KA R E G + +D
Sbjct: 360 RFAFDKFPTANQVLGSQMKSVGEVMAVGRTFEEALQKA-----IRSLEIGRYGLGCDGKD 414
Query: 413 KPKILELAKEFEKLGFGIYATSGTYKFLKEHGVNAKRVLKVSEGRPNVVDMIIN 466
K +E + E+L + + ++ + G++ + ++++ P +D I N
Sbjct: 415 KEVTMEEIR--ERLRYPNASRVFYIRYALQKGMSVNEIYELTKIDPWFIDKIKN 466
pir||D64472 carbamoyl-phosphate synthase, pyrimidine-specific, large subunit
(EC 6.3.-.-) - Methanococcus jannaschii >gi|1592027
(U67578) carbamoyl-phosphate synthase, large subunit
(carB2) [Methanococcus jannaschii]
Length = 618
Score = 606 bits (1546), Expect = e-172
Identities = 318/537 (59%), Positives = 402/537 (74%), Gaps = 16/537 (2%)
Query: 3 KKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFE 62
KKV+I+GSGP RIGQGIEFDY+ VHAV +L+E G A+++N NPETVSTDYDT+DKLYFE
Sbjct: 85 KKVIIIGSGPIRIGQGIEFDYSSVHAVLALKEMGIEAIIINNNPETVSTDYDTSDKLYFE 144
Query: 63 PIVFEHVMDIIEREKPEG----VILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDR 118
PI FE V++I EREK +G VI+QFGGQT + LA+ L+ GV ILGT PE+I+ AEDR
Sbjct: 145 PITFEEVLNIAEREKEKGELLGVIVQFGGQTAINLAMKLKNAGVNILGTTPENINAAEDR 204
Query: 119 ELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXX 178
E F +L+ +L + Q GTA TKEEAL+IAK IG+PVLVRPSYVLGGRAM+IVY
Sbjct: 205 EEFSKLLKKLNIPQAEGGTAYTKEEALEIAKRIGYPVLVRPSYVLGGRAMQIVYSEDELI 264
Query: 179 XXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATS 238
AV VS E PVLIDKFL+++IELDVDAV DG+ VLIGA+MEHIEEAGVHSGDSAT
Sbjct: 265 EYMEEAVKVSEEHPVLIDKFLEDAIELDVDAVCDGESVLIGAIMEHIEEAGVHSGDSATV 324
Query: 239 IPPYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSK 298
IPP +L KEI++ V + T KLA AL + GL+NVQYAV++ VYVLE NPRASRTVP+VSK
Sbjct: 325 IPPQTLPKEIIDTVIDYTAKLARALNIVGLLNVQYAVKDGVVYVLEANPRASRTVPYVSK 384
Query: 299 SIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKR 358
S+G PLAK+ATK+ +GK L E++ + +EK A + K S+KE VFP+++
Sbjct: 385 SVGIPLAKLATKIMLGKKLEELIKDY--DVEK----VAEKVWIAKPKYVSIKEAVFPFQK 438
Query: 359 FPEVDPILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILE 418
P VDP+LGPEMKSTGE +GIDK+FG AYYKAQLSA LP GN+FISV DRDK I++
Sbjct: 439 LPGVDPVLGPEMKSTGEAIGIDKDFGRAYYKAQLSANMELPIVGNVFISVRDRDKKHIVD 498
Query: 419 LAKEFEKLGFGIYATSGTYKFLKEHGVNAKRVLKVSEG-RPNVVDMIINGEIHLVINTPS 477
+AK+ +LGF IYAT GT K L+E+G+ A V K+SE N++ ++ +G++HL+INT S
Sbjct: 499 VAKKLHELGFTIYATEGTAKVLRENGIPAILVKKISESPNDNILKLMRDGKMHLIINTSS 558
Query: 478 GKREKSDAYYIRRACVQFNVPYYTTMRAGYAVLEAIKSIKKLKEEGKGLSVHSLQEI 534
GK+ KSD YYIRRA V +PY TT+ A ++AI+++K + LSV+SL E+
Sbjct: 559 GKKAKSDGYYIRRAAVDLGIPYITTIPGAKAAVKAIEAVKTGE-----LSVYSLDEL 610
gb|AAF16526.1|AF191301_2 (AF191301) ADP-forming, carbamate-phosphorylating [Medicago sativa]
Length = 1072
Score = 567 bits (1445), Expect = e-161
Identities = 279/518 (53%), Positives = 371/518 (70%), Gaps = 16/518 (3%)
Query: 3 KKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFE 62
KK++++G GPNRIGQGIEFDY CVHA +++E+GY +MVNCNPETVSTDYDT+D+L+FE
Sbjct: 559 KKILVIGGGPNRIGQGIEFDYCCVHAALAMREDGYETIMVNCNPETVSTDYDTSDRLFFE 618
Query: 63 PIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFR 122
P+ E V++I+ +EKP GVI+QFGGQTPLKLA L+ GV I+GT P++IDKAEDRE F+
Sbjct: 619 PVTLEDVLEIVHKEKPVGVIVQFGGQTPLKLARALEAEGVPIIGTSPDAIDKAEDRERFQ 678
Query: 123 ELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXX 182
++I +LGL QPP+ R+ EEAL A ++G+P++VRPSYVLGGRAM IVY
Sbjct: 679 QMINKLGLLQPPNAIVRSLEEALLAADKVGYPLVVRPSYVLGGRAMEIVYKEDELRTYMR 738
Query: 183 XAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPY 242
AV VS + PVL+D FL+N+IE+D+D+VSDGK V+IG +M+HIE+ GVHSGDSA S+PPY
Sbjct: 739 TAVQVSEDAPVLLDHFLNNAIEVDIDSVSDGKQVVIGGIMQHIEQCGVHSGDSACSLPPY 798
Query: 243 SLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGY 302
SL ++ ++++E +K+A+ L V GL+N Q A Q+ ++YV+EVNPRASRTVPFVSK IG
Sbjct: 799 SLPADVQDDMREIVKKMAIELGVIGLMNTQLAYQDGKIYVIEVNPRASRTVPFVSKCIGV 858
Query: 303 PLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEV 362
LAK+A + G SL E F + +P FSVKE VFP+ +FP V
Sbjct: 859 SLAKVAARCQAGVSLE-------------EQGFTKEIIP---DYFSVKEAVFPFNKFPAV 902
Query: 363 DPILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILELAKE 422
DPILGPEMKSTGEVMG+ FG AY K+QL A R+P G FISV D DK I+ + K+
Sbjct: 903 DPILGPEMKSTGEVMGVGNTFGEAYGKSQLGANNRIPTSGTAFISVRDMDKDGIVSVGKD 962
Query: 423 FEKLGFGIYATSGTYKFLKEHGVNAKRVLKVSEGRPNVVDMIINGEIHLVINTPSGKREK 482
+LGF + AT GT + L++ G+ + V KV EGRP++VDMI N EI L+INT G++
Sbjct: 963 LAELGFKLVATRGTAEVLQQAGLTVQIVNKVQEGRPHIVDMIKNDEIDLIINTVEGRQAT 1022
Query: 483 SDAYYIRRACVQFNVPYYTTMRAGYAVLEAIKSIKKLK 520
D+ IRR+ V Y TT+ AG+AV ++K +K ++
Sbjct: 1023 RDSSSIRRSAENHRVYYNTTLAAGFAVCMSLKEVKDIE 1060
Score = 230 bits (580), Expect = 2e-59
Identities = 148/398 (37%), Positives = 224/398 (56%), Gaps = 21/398 (5%)
Query: 5 VVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEPI 64
++ILG+GP IGQ EFDY+ A +L+EEGY ++VN NP T+ TD AD Y EPI
Sbjct: 10 ILILGAGPIVIGQACEFDYSGAQACKALREEGYRVILVNSNPATIMTDPAMADATYIEPI 69
Query: 65 VFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNG------VKILGTKPESIDKAEDR 118
++ V IIE+E+P+ ++ GGQT L AL L KNG V+++G K E+I+ AEDR
Sbjct: 70 EWQTVAKIIEKERPDVILPTMGGQTALNCALALAKNGVLEKYNVELIGAKEEAINMAEDR 129
Query: 119 ELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXX 178
LF + + +GL + T EEA + KE GFP ++RPS+ +GG I Y+
Sbjct: 130 NLFDQAMKRIGLSCARAKIVHTLEEAKEAPKEFGFPCIIRPSFTMGGSGGGIAYNWDEFE 189
Query: 179 XXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKD-VLIGAVMEHIEEAGVHSGDSAT 237
+ +S +LID+ L E +++ V D D +I +E+ + GVH+GDS T
Sbjct: 190 EICTRGLDLSPTNELLIDESLLGWKEYEMEVVRDKNDNCIIVCSIENFDPMGVHTGDSIT 249
Query: 238 SIPPYSLSKEIVEEVKEQTRKLAVALEV---KGLINVQYAVQ--NNEVYVLEVNPRASRT 292
P +L+ + + ++ + +AV E+ G NVQ+AV + + V+E+NPR SR+
Sbjct: 250 VAPAQTLTDKEYQIMRNAS--IAVLREIGVETGGSNVQFAVNPVDGRMVVIEMNPRVSRS 307
Query: 293 VPFVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEV 352
SK+ G+P+AKIA K+A+G +L E+ ++ G A AS F P + + K
Sbjct: 308 SALASKATGFPIAKIAAKLAVGYTLDELKNDI-----TGGATPAS-FEPSIDYVVT-KVP 360
Query: 353 VFPWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKA 390
F +++F + D L +MKS GEVM I + F + KA
Sbjct: 361 RFTFEKFGDADARLTTQMKSVGEVMAIGRTFQESLQKA 398
gi|2622097 (AE000872) carbamoyl-phosphate synthase, large subunit
[Methanobacterium thermoautotrophicum]
Length = 828
Score = 566 bits (1442), Expect = e-160
Identities = 295/539 (54%), Positives = 385/539 (70%), Gaps = 27/539 (5%)
Query: 3 KKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFE 62
+KV+I+GSGP RIGQGIEFDY CVHA +L E+GY +MVN NPETVSTDYD +DKLYFE
Sbjct: 313 RKVLIIGSGPIRIGQGIEFDYCCVHAAMALTEDGYETIMVNNNPETVSTDYDISDKLYFE 372
Query: 63 PIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFR 122
P+ E V+ IIE+EKPEGV++QFGGQT + LA+PL + GV+ILGT ESID+ EDRE F
Sbjct: 373 PLTLEDVLAIIEKEKPEGVVVQFGGQTSINLAVPLAEAGVRILGTPHESIDRVEDRERFT 432
Query: 123 ELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXX 182
E++ +LG+ Q P G A++ E+A +A+ IG+PVLVRPSYVLGGRAM IVYD
Sbjct: 433 EVLNKLGIPQAPYGIAKSFEDARAVAERIGYPVLVRPSYVLGGRAMEIVYDDVELEEYMR 492
Query: 183 XAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPY 242
AV VS E P+L+DKFL+++IE+DVDA+ DG DV IG +MEHIEEAGVHSGDSA IPP
Sbjct: 493 EAVRVSPEHPILVDKFLEDAIEVDVDALCDGTDVYIGGIMEHIEEAGVHSGDSACVIPPQ 552
Query: 243 SLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQ---NNEVYVLEVNPRASRTVPFVSKS 299
S+ ++I++ +KE TRKLA+ LEV GLIN+QYAV+ + VY+LE NPRASRTVPFVSK+
Sbjct: 553 SIPEDIIDTIKEYTRKLALELEVVGLINIQYAVKPDSDPSVYILEANPRASRTVPFVSKA 612
Query: 300 IGYPLAKIATKVAIGKSLREI-LPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKR 358
G PLAK+A ++ +G LR++ L E EK H A VKE VFP+ +
Sbjct: 613 TGVPLAKMAARLMMGAKLRDLGLTE-----EKDIEHVA------------VKESVFPFIK 655
Query: 359 FPEVDPILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILE 418
P D +LGPEMKSTGE MGID+ FG+AYYK+QLSA L +G +FISV D+DK KI +
Sbjct: 656 LPGADSVLGPEMKSTGEAMGIDENFGIAYYKSQLSASMDLLNEGKVFISVRDQDKDKIAD 715
Query: 419 LAKEFEKLGFGIYATSGTYKFLKEHGVNAKRVLKVSEGRPNVVDMIINGEIHLVINTPSG 478
+ K+ ++LGF I AT GT + + + + + V KVS+G PN+ D I++GE+ L+INTPSG
Sbjct: 716 IVKKADELGFRIMATRGTARAVSDI-ADIEVVRKVSQGSPNIRDAILDGEVGLIINTPSG 774
Query: 479 KREKSDAYYIRRACVQFNVPYYTTMRAGYAVLEAIKSIKKLKEEGKGLSVHSLQEIYNI 537
K+ D Y IRR V+ +PY TT+ A L AI++++ K ++V SL E + +
Sbjct: 775 KQSADDGYLIRRMAVELGIPYVTTLAGARAALNAIEAVRMGK-----ITVKSLDEYHGM 828
Score = 100 bits (246), Expect = 4e-20
Identities = 60/171 (35%), Positives = 98/171 (57%), Gaps = 10/171 (5%)
Query: 222 MEHIEEAGVHSGDSATSIPPYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAV--QNNE 279
ME+I+ G+H+G+S P +LS E + +++ K+ AL+++G N+Q+AV + E
Sbjct: 1 MENIDPMGIHTGESVVVAPAQTLSDEDNQRLRDAAIKIIRALKIEGGCNIQFAVHPETGE 60
Query: 280 VYVLEVNPRASRTVPFVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDF 339
V+EVNPR SR+ SK+ GYP+AKIA K+A+G +L EI ++ + + F
Sbjct: 61 YKVIEVNPRVSRSSALASKATGYPIAKIAAKIAVGMTLDEIQNDITKET-------PASF 113
Query: 340 LPKEKKIFSVKEVVFPWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKA 390
P + + K +P+ +F + +G +MKSTGEVM I + + KA
Sbjct: 114 EPTIDYVVT-KIPRWPFDKFKGISREIGVQMKSTGEVMAIGRTLEESLNKA 163
gi|1750387 (U81259) carbamoylphosphate synthetase large subunit [Pseudomonas
aeruginosa]
Length = 1073
Score = 560 bits (1428), Expect = e-159
Identities = 279/529 (52%), Positives = 383/529 (71%), Gaps = 21/529 (3%)
Query: 3 KKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFE 62
+K++ILG GPNRIGQGIEFDY CVHA +++E+GY +MVNCNPETVSTDYDT+D+LYFE
Sbjct: 559 EKIMILGGGPNRIGQGIEFDYCCVHAALAMREDGYETIMVNCNPETVSTDYDTSDRLYFE 618
Query: 63 PIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFR 122
P+ E V++I+ E+P+GVI+Q+GGQTPLKL L++ GV I+GT P++ID+AEDRE F+
Sbjct: 619 PVTLEDVLEIVRVEQPKGVIVQYGGQTPLKLCRALEEAGVPIIGTSPDAIDRAEDRERFQ 678
Query: 123 ELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXX 182
+++ L L+QP + TAR+++EAL +K IG+P++VRPSYVLGGRAM IVY
Sbjct: 679 QMVQRLNLRQPANATARSEDEALAASKAIGYPLVVRPSYVLGGRAMEIVYQEEELKRYMR 738
Query: 183 XAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPY 242
AV VS++ PVL+D FL+ +IE+D+DAV DG+ V+IGA+M+HIE+AGVHSGDSA S+PPY
Sbjct: 739 EAVQVSNDSPVLLDHFLNCAIEVDIDAVCDGEIVVIGAIMQHIEQAGVHSGDSACSLPPY 798
Query: 243 SLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGY 302
SL + I +E++EQ +K+A+ L V GL+NVQ AVQ +++V+EVNPRASRTVPFVSK +G
Sbjct: 799 SLPQHIQDEIREQVKKMALELGVVGLMNVQMAVQGEDIFVIEVNPRASRTVPFVSKCVGE 858
Query: 303 PLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEV 362
LAK+A +V GK+L E+ F + +P FSVKE VFP+ +FP V
Sbjct: 859 SLAKVAARVMAGKTLAEV-------------GFTQEIIP---PFFSVKEAVFPFAKFPGV 902
Query: 363 DPILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILELAKE 422
DPILGPEMKSTGEVMG+ F A+ KAQL A LP G FISV + DKP ++A +
Sbjct: 903 DPILGPEMKSTGEVMGVGDSFAEAFAKAQLGASEILPTAGCAFISVREDDKPFAAQVAGD 962
Query: 423 FEKLGFGIYATSGTYKFLKEHGVNAKRVLKVSEGRPNVVDMIINGEIHLVINTPSGKREK 482
LGF + AT+GT + ++ G+ +RV KV+EGRP+VVDMI N E+ L+INT G++
Sbjct: 963 LVALGFEVVATAGTARVIEAAGLPVRRVNKVTEGRPHVVDMIKNDEVTLIINTTEGRQSI 1022
Query: 483 SDAYYIRRACVQFNVPYYTTMRAGYAVLEAI-----KSIKKLKEEGKGL 526
+D+Y IRR +Q + TT+ G A+ EA+ K++++L++ G+
Sbjct: 1023 ADSYSIRRNALQHKICCTTTIAGGQAICEALKFGPEKTVRRLQDLHAGI 1071
Score = 239 bits (603), Expect = 5e-62
Identities = 145/400 (36%), Positives = 226/400 (56%), Gaps = 21/400 (5%)
Query: 3 KKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFE 62
K ++ILG+GP IGQ EFDY+ A +L+EEGY ++VN NP T+ TD AD Y E
Sbjct: 8 KSILILGAGPIVIGQACEFDYSGAQACKALREEGYRVILVNSNPATIMTDPAMADATYIE 67
Query: 63 PIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKN------GVKILGTKPESIDKAE 116
PI + V IIE+E+P+ ++ GGQT L AL L+++ GV+++G ++IDKAE
Sbjct: 68 PIKWATVAKIIEKERPDALLPTMGGQTALNCALDLERHGVLEKFGVEMIGANADTIDKAE 127
Query: 117 DRELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXX 176
DR F + + ++GL P SG A + EEA + +++GFP ++RPS+ +GG I Y+
Sbjct: 128 DRSRFDKAMKDIGLACPRSGIAHSMEEAYGVLEQVGFPCIIRPSFTMGGTGGGIAYNREE 187
Query: 177 XXXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKD-VLIGAVMEHIEEAGVHSGDS 235
+ +S +LID+ L E +++ V D KD +I +E+ + GVH+GDS
Sbjct: 188 FEEICARGLDLSPTNELLIDESLIGWKEYEMEVVRDKKDNCIIVCSIENFDPMGVHTGDS 247
Query: 236 ATSIPPYSLSKEIVEEVKEQTRKLAVALEV---KGLINVQYAVQNN--EVYVLEVNPRAS 290
T P +L+ + + ++ + LAV E+ G NVQ+ + N + V+E+NPR S
Sbjct: 248 ITVAPAQTLTDKEYQIMRNAS--LAVLREIGVETGGSNVQFGICPNTGRMVVIEMNPRVS 305
Query: 291 RTVPFVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVK 350
R+ SK+ G+P+AKIA K+A+G +L E+ ++ A D++ K
Sbjct: 306 RSSALASKATGFPIAKIAAKLAVGYTLDELQNDITGGRTPASFEPAIDYV-------VTK 358
Query: 351 EVVFPWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKA 390
F +++FP+ D L +MKS GEVM I + F + KA
Sbjct: 359 IPRFAFEKFPKADARLTTQMKSVGEVMAIGRTFQESVQKA 398
pdb|1CE8|A Chain A, Carbamoyl Phosphate Synthetase From Escherichis Coli With
Complexed With The Allosteric Ligand Imp
>gi|5821978|pdb|1CE8|C Chain C, Carbamoyl Phosphate
Synthetase From Escherichis Coli With Complexed With The
Allosteric Ligand Imp >gi|5821980|pdb|1CE8|E Chain E,
Carbamoyl Phosphate Synthetase From Escherichis Coli With
Complexed With The Allosteric Ligand Imp
>gi|5821982|pdb|1CE8|G Chain G, Carbamoyl Phosphate
Synthetase From Escherichis Coli With Complexed With The
Allosteric Ligand Imp
Length = 1073
Score = 554 bits (1413), Expect = e-157
Identities = 275/513 (53%), Positives = 371/513 (71%), Gaps = 16/513 (3%)
Query: 3 KKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFE 62
+K+++LG GPNRIGQGIEFDY CVHA +L+E+GY +MVNCNPETVSTDYDT+D+LYFE
Sbjct: 560 EKIMVLGGGPNRIGQGIEFDYCCVHASLALREDGYETIMVNCNPETVSTDYDTSDRLYFE 619
Query: 63 PIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFR 122
P+ E V++I+ EKP+GVI+Q+GGQTPLKLA L+ GV ++GT P++ID+AEDRE F+
Sbjct: 620 PVTLEDVLEIVRIEKPKGVIVQYGGQTPLKLARALEAAGVPVIGTSPDAIDRAEDRERFQ 679
Query: 123 ELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXX 182
+ L LKQP + T E A++ AKEIG+P++VRPSYVLGGRAM IVYD
Sbjct: 680 HAVERLKLKQPANATVTAIEMAVEKAKEIGYPLVVRPSYVLGGRAMEIVYDEADLRRYFQ 739
Query: 183 XAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPY 242
AVSVS++ PVL+D FLD+++E+DVDA+ DG+ VLIG +MEHIE+AGVHSGDSA S+P Y
Sbjct: 740 TAVSVSNDAPVLLDHFLDDAVEVDVDAICDGEMVLIGGIMEHIEQAGVHSGDSACSLPAY 799
Query: 243 SLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGY 302
+LS+EI + +++Q +KLA L+V+GL+NVQ+AV+NNEVY++EVNPRA+RTVPFVSK+ G
Sbjct: 800 TLSQEIQDVMRQQVQKLAFELQVRGLMNVQFAVKNNEVYLIEVNPRAARTVPFVSKATGV 859
Query: 303 PLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEV 362
PLAK+A +V GKSL E + +P +SVKEVV P+ +FP V
Sbjct: 860 PLAKVAARVMAGKSL-------------AEQGVTKEVIP---PYYSVKEVVLPFNKFPGV 903
Query: 363 DPILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILELAKE 422
DP+LGPEM+STGEVMG+ + F A+ KAQL + + + G +SV + DK ++++LA +
Sbjct: 904 DPLLGPEMRSTGEVMGVGRTFAEAFAKAQLGSNSTMKKHGRALLSVREGDKERVVDLAAK 963
Query: 423 FEKLGFGIYATSGTYKFLKEHGVNAKRVLKVSEGRPNVVDMIINGEIHLVINTPSGKREK 482
K GF + AT GT L E G+N + V KV EGRP++ D I NGE +INT SG+R
Sbjct: 964 LLKQGFELDATHGTAIVLGEAGINPRLVNKVHEGRPHIQDRIKNGEYTYIINTTSGRRAI 1023
Query: 483 SDAYYIRRACVQFNVPYYTTMRAGYAVLEAIKS 515
D+ IRR+ +Q+ V Y TT+ G+A A+ +
Sbjct: 1024 EDSRVIRRSALQYKVHYDTTLNGGFATAMALNA 1056
Score = 234 bits (591), Expect = 1e-60
Identities = 141/391 (36%), Positives = 222/391 (56%), Gaps = 21/391 (5%)
Query: 3 KKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFE 62
K ++ILG+GP IGQ EFDY+ A +L+EEGY + VN NP T+ TD + AD Y E
Sbjct: 8 KSILILGAGPIVIGQACEFDYSGAQACKALREEGYRVINVNSNPATIMTDPEMADATYIE 67
Query: 63 PIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKN------GVKILGTKPESIDKAE 116
PI +E V IIE+E+P+ V+ GGQT L AL L++ GV ++G ++IDKAE
Sbjct: 68 PIHWEVVRKIIEKERPDAVLPTMGGQTALNCALELERQGVLEEFGVTMIGATADAIDKAE 127
Query: 117 DRELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXX 176
DR F + ++GL+ SG A T EEAL +A ++GFP ++RPS+ +GG I Y+
Sbjct: 128 DRRRFDVAMKKIGLETARSGIAHTMEEALAVAADVGFPCIIRPSFTMGGSGGGIAYNREE 187
Query: 177 XXXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKD-VLIGAVMEHIEEAGVHSGDS 235
+ +S + +LID+ L E +++ V D D +I +E+ + G+H+GDS
Sbjct: 188 FEEICARGLDLSPTKELLIDESLIGWKEYEMEVVRDKNDNCIIVCSIENFDAMGIHTGDS 247
Query: 236 ATSIPPYSLSKEIVEEVKEQTRKLAVALEV---KGLINVQYAV--QNNEVYVLEVNPRAS 290
T P +L+ + + ++ + +AV E+ G NVQ+AV +N + V+E+NPR S
Sbjct: 248 ITVAPAQTLTDKEYQIMRNAS--MAVLREIGVETGGSNVQFAVNPKNGRLIVIEMNPRVS 305
Query: 291 RTVPFVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVK 350
R+ SK+ G+P+AK+A K+A+G +L E++ ++ + D++ K
Sbjct: 306 RSSALASKATGFPIAKVAAKLAVGYTLDELMNDITGGRTPASFEPSIDYV-------VTK 358
Query: 351 EVVFPWKRFPEVDPILGPEMKSTGEVMGIDK 381
F +++F + L +MKS GEVM I +
Sbjct: 359 IPRFNFEKFAGANDRLTTQMKSVGEVMAIGR 389
sp|P14846|CARB_SALTY CARBAMOYL-PHOSPHATE SYNTHASE LARGE CHAIN (CARBAMOYL-PHOSPHATE
SYNTHETASE AMMONIA CHAIN) >gi|1750392 (U81260)
carbamoylphosphate synthetase large subunit [Salmonella
typhimurium]
Length = 1075
Score = 554 bits (1413), Expect = e-157
Identities = 273/512 (53%), Positives = 373/512 (72%), Gaps = 16/512 (3%)
Query: 4 KVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEP 63
K+++LG GPNRIGQGIEFDY CVHA +L+E+GY +MVNCNPETVSTDYDT+D+LYFEP
Sbjct: 561 KIMVLGGGPNRIGQGIEFDYCCVHASLALREDGYETIMVNCNPETVSTDYDTSDRLYFEP 620
Query: 64 IVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFRE 123
+ E V++I+ EKP+GVI+Q+GGQTPLKLA L+ GV ++GT P++ID+AEDRE F+
Sbjct: 621 VTLEDVLEIVRIEKPKGVIVQYGGQTPLKLARALEAAGVPVIGTSPDAIDRAEDRERFQH 680
Query: 124 LIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXXX 183
+ L LKQP + T E+A++ AKEIG+P++VRPSYVLGGRAM IVYD
Sbjct: 681 AVDRLKLKQPANATVTAIEQAVEKAKEIGYPLVVRPSYVLGGRAMEIVYDEADLRRYFQT 740
Query: 184 AVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPYS 243
AVSVS++ PVL+D+FLD+++E+DVDA+ DG+ VLIG +MEHIE+AGVHSGDSA S+P Y+
Sbjct: 741 AVSVSNDAPVLLDRFLDDAVEVDVDAICDGEMVLIGGIMEHIEQAGVHSGDSACSLPAYT 800
Query: 244 LSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGYP 303
LS+EI + +++Q +KLA L+V+GL+NVQ+AV++NEVY++EVNPRA+RTVPFVSK+ G P
Sbjct: 801 LSQEIQDVMRQQVQKLAFELQVRGLMNVQFAVKDNEVYLIEVNPRAARTVPFVSKATGVP 860
Query: 304 LAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEVD 363
LAK+A +V GKSL E + +P +SVKEVV P+ +FP VD
Sbjct: 861 LAKVAARVMAGKSLT-------------EQGVTQEIIP---PYYSVKEVVLPFNKFPGVD 904
Query: 364 PILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILELAKEF 423
P+LGPEM+STGEVMG+ + F A+ KAQL + + ++G +SV + DK ++++LA +
Sbjct: 905 PLLGPEMRSTGEVMGVGRTFAEAFAKAQLGSNSTMKKQGRALLSVREGDKERVVDLAAKL 964
Query: 424 EKLGFGIYATSGTYKFLKEHGVNAKRVLKVSEGRPNVVDMIINGEIHLVINTPSGKREKS 483
K GF + AT GT L E G+N + V KV EGRP++ D I NGE +INT +G+R
Sbjct: 965 LKQGFELDATHGTAIVLGEAGINPRLVNKVHEGRPHIQDRIKNGEYTYIINTTAGRRAIE 1024
Query: 484 DAYYIRRACVQFNVPYYTTMRAGYAVLEAIKS 515
D+ IRR+ +Q+ V Y TT+ G+A A+ +
Sbjct: 1025 DSRVIRRSALQYKVHYDTTLNGGFATTMALNA 1056
Score = 230 bits (581), Expect = 2e-59
Identities = 140/391 (35%), Positives = 220/391 (55%), Gaps = 21/391 (5%)
Query: 3 KKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFE 62
K ++ILG+GP IGQ EFDY+ A +L+EEGY ++VN NP T+ TD + AD Y E
Sbjct: 8 KSILILGAGPIVIGQACEFDYSGAQACKALREEGYRVILVNSNPATIMTDPEMADATYIE 67
Query: 63 PIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKN------GVKILGTKPESIDKAE 116
PI +E V IIE+E+P+ V+ GGQT L AL L++ GV ++G ++ DKAE
Sbjct: 68 PIHWEVVRKIIEKERPDAVLPTMGGQTALNCALELERQGVLEEFGVTMIGATADAGDKAE 127
Query: 117 DRELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXX 176
DR F + ++GL SG A T EEAL +A ++GFP ++RPS+ +GG I Y+
Sbjct: 128 DRRRFDIAMKKIGLDTARSGIAHTMEEALAVAADVGFPCIIRPSFTMGGTGGGIAYNREE 187
Query: 177 XXXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKD-VLIGAVMEHIEEAGVHSGDS 235
+ +S +LID+ L E +++ V D D +I +E+ + G+H+GDS
Sbjct: 188 FEEICERGLDLSPTNELLIDESLIGWKEYEMEVVRDKNDNCIIVCSIENFDAMGIHTGDS 247
Query: 236 ATSIPPYSLSKEIVEEVKEQTRKLAVALEV---KGLINVQYAV--QNNEVYVLEVNPRAS 290
T P +L+ + + ++ + +AV E+ G NVQ+AV +N + V+E+NPR S
Sbjct: 248 ITVAPAQTLTDKEYQIMRNAS--MAVLREIGVETGGSNVQFAVNPKNGRLIVIEMNPRVS 305
Query: 291 RTVPFVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVK 350
R+ SK+ G+P+AK+A K+A+G +L E++ ++ + D++ K
Sbjct: 306 RSSALASKATGFPIAKVAAKLAVGYTLDELMNDITGGRTPASFEPSIDYV-------VTK 358
Query: 351 EVVFPWKRFPEVDPILGPEMKSTGEVMGIDK 381
F +++F + L +MKS GEVM I +
Sbjct: 359 IPRFNFEKFAGANDRLTTQMKSVGEVMAIGR 389
sp|P00968|CARB_ECOLI CARBAMOYL-PHOSPHATE SYNTHASE LARGE CHAIN (CARBAMOYL-PHOSPHATE
SYNTHETASE AMMONIA CHAIN) >gi|68663|pir||SYECCP
carbamoyl-phosphate synthase (glutamine-hydrolyzing) (EC
6.3.5.5) large chain - Escherichia coli
>gi|3318817|pdb|1JDB|B Chain B, Carbamoyl Phosphate
Synthetase From Escherichia Coli >gi|3318821|pdb|1JDB|E
Chain E, Carbamoyl Phosphate Synthetase From Escherichia
Coli >gi|3318825|pdb|1JDB|H Chain H, Carbamoyl Phosphate
Synthetase From Escherichia Coli >gi|3318829|pdb|1JDB|K
Chain K, Carbamoyl Phosphate Synthetase From Escherichia
Coli >gi|4929935|pdb|1BXR|A Chain A, Structure Of
Carbamoyl Phosphate Synthetase Complexed With The Atp
Analog Amppnp >gi|4929937|pdb|1BXR|C Chain C, Structure
Of Carbamoyl Phosphate Synthetase Complexed With The Atp
Analog Amppnp >gi|4929939|pdb|1BXR|E Chain E, Structure
Of Carbamoyl Phosphate Synthetase Complexed With The Atp
Analog Amppnp >gi|4929941|pdb|1BXR|G Chain G, Structure
Of Carbamoyl Phosphate Synthetase Complexed With The Atp
Analog Amppnp >gi|41079|emb|CAA24744.1| (V01500) carB
reading frame [Escherichia coli] >gi|145464 (J01597)
carbamoyl-phosphate synthetase subunit B [Escherichia
coli] >gi|216460|dbj|BAA01311| (D10483)
carbamoyl-phosphate synthase large chain [Escherichia
coli] >gi|1786216 (AE000113) carbamoyl-phosphate synthase
large subunit [Escherichia coli]
Length = 1073
Score = 554 bits (1413), Expect = e-157
Identities = 275/513 (53%), Positives = 371/513 (71%), Gaps = 16/513 (3%)
Query: 3 KKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFE 62
+K+++LG GPNRIGQGIEFDY CVHA +L+E+GY +MVNCNPETVSTDYDT+D+LYFE
Sbjct: 560 EKIMVLGGGPNRIGQGIEFDYCCVHASLALREDGYETIMVNCNPETVSTDYDTSDRLYFE 619
Query: 63 PIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFR 122
P+ E V++I+ EKP+GVI+Q+GGQTPLKLA L+ GV ++GT P++ID+AEDRE F+
Sbjct: 620 PVTLEDVLEIVRIEKPKGVIVQYGGQTPLKLARALEAAGVPVIGTSPDAIDRAEDRERFQ 679
Query: 123 ELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXX 182
+ L LKQP + T E A++ AKEIG+P++VRPSYVLGGRAM IVYD
Sbjct: 680 HAVERLKLKQPANATVTAIEMAVEKAKEIGYPLVVRPSYVLGGRAMEIVYDEADLRRYFQ 739
Query: 183 XAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPY 242
AVSVS++ PVL+D FLD+++E+DVDA+ DG+ VLIG +MEHIE+AGVHSGDSA S+P Y
Sbjct: 740 TAVSVSNDAPVLLDHFLDDAVEVDVDAICDGEMVLIGGIMEHIEQAGVHSGDSACSLPAY 799
Query: 243 SLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGY 302
+LS+EI + +++Q +KLA L+V+GL+NVQ+AV+NNEVY++EVNPRA+RTVPFVSK+ G
Sbjct: 800 TLSQEIQDVMRQQVQKLAFELQVRGLMNVQFAVKNNEVYLIEVNPRAARTVPFVSKATGV 859
Query: 303 PLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEV 362
PLAK+A +V GKSL E + +P +SVKEVV P+ +FP V
Sbjct: 860 PLAKVAARVMAGKSL-------------AEQGVTKEVIP---PYYSVKEVVLPFNKFPGV 903
Query: 363 DPILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILELAKE 422
DP+LGPEM+STGEVMG+ + F A+ KAQL + + + G +SV + DK ++++LA +
Sbjct: 904 DPLLGPEMRSTGEVMGVGRTFAEAFAKAQLGSNSTMKKHGRALLSVREGDKERVVDLAAK 963
Query: 423 FEKLGFGIYATSGTYKFLKEHGVNAKRVLKVSEGRPNVVDMIINGEIHLVINTPSGKREK 482
K GF + AT GT L E G+N + V KV EGRP++ D I NGE +INT SG+R
Sbjct: 964 LLKQGFELDATHGTAIVLGEAGINPRLVNKVHEGRPHIQDRIKNGEYTYIINTTSGRRAI 1023
Query: 483 SDAYYIRRACVQFNVPYYTTMRAGYAVLEAIKS 515
D+ IRR+ +Q+ V Y TT+ G+A A+ +
Sbjct: 1024 EDSRVIRRSALQYKVHYDTTLNGGFATAMALNA 1056
Score = 236 bits (595), Expect = 4e-61
Identities = 141/391 (36%), Positives = 223/391 (56%), Gaps = 21/391 (5%)
Query: 3 KKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFE 62
K ++ILG+GP IGQ EFDY+ A +L+EEGY ++VN NP T+ TD + AD Y E
Sbjct: 8 KSILILGAGPIVIGQACEFDYSGAQACKALREEGYRVILVNSNPATIMTDPEMADATYIE 67
Query: 63 PIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKN------GVKILGTKPESIDKAE 116
PI +E V IIE+E+P+ V+ GGQT L AL L++ GV ++G ++IDKAE
Sbjct: 68 PIHWEVVRKIIEKERPDAVLPTMGGQTALNCALELERQGVLEEFGVTMIGATADAIDKAE 127
Query: 117 DRELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXX 176
DR F + ++GL+ SG A T EEAL +A ++GFP ++RPS+ +GG I Y+
Sbjct: 128 DRRRFDVAMKKIGLETARSGIAHTMEEALAVAADVGFPCIIRPSFTMGGSGGGIAYNREE 187
Query: 177 XXXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKD-VLIGAVMEHIEEAGVHSGDS 235
+ +S + +LID+ L E +++ V D D +I +E+ + G+H+GDS
Sbjct: 188 FEEICARGLDLSPTKELLIDESLIGWKEYEMEVVRDKNDNCIIVCSIENFDAMGIHTGDS 247
Query: 236 ATSIPPYSLSKEIVEEVKEQTRKLAVALEV---KGLINVQYAV--QNNEVYVLEVNPRAS 290
T P +L+ + + ++ + +AV E+ G NVQ+AV +N + V+E+NPR S
Sbjct: 248 ITVAPAQTLTDKEYQIMRNAS--MAVLREIGVETGGSNVQFAVNPKNGRLIVIEMNPRVS 305
Query: 291 RTVPFVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVK 350
R+ SK+ G+P+AK+A K+A+G +L E++ ++ + D++ K
Sbjct: 306 RSSALASKATGFPIAKVAAKLAVGYTLDELMNDITGGRTPASFEPSIDYV-------VTK 358
Query: 351 EVVFPWKRFPEVDPILGPEMKSTGEVMGIDK 381
F +++F + L +MKS GEVM I +
Sbjct: 359 IPRFNFEKFAGANDRLTTQMKSVGEVMAIGR 389
dbj|BAA10403| (D64002) carbamoyl-phosphate synthase, pyrimidine-specific, large
chain [Synechocystis sp.]
Length = 1105
Score = 542 bits (1382), Expect = e-153
Identities = 278/524 (53%), Positives = 366/524 (69%), Gaps = 26/524 (4%)
Query: 4 KVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEP 63
KV+ILG GPNRIGQGIEFDY C HA FSL + GY +MVN NPETVSTDYDT+D+LYFEP
Sbjct: 584 KVMILGGGPNRIGQGIEFDYCCCHAAFSLSDAGYETIMVNSNPETVSTDYDTSDRLYFEP 643
Query: 64 IVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKN--------GVKILGTKPESIDKA 115
+ E V++IIE E P G+I+QFGGQTPLKLA+PLQK KI GT P+SID A
Sbjct: 644 LTKEDVLNIIEAENPVGIIIQFGGQTPLKLAVPLQKYLNSPDCPVQTKIWGTSPDSIDTA 703
Query: 116 EDRELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXX 175
EDRE F +++ EL + QPP+G AR EE+ +A I +PV+VRPSYVLGGRAM IVY
Sbjct: 704 EDRERFEKILHELEISQPPNGIARDYEESRVVANRISYPVVVRPSYVLGGRAMEIVYSDE 763
Query: 176 XXXXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGK-DVLIGAVMEHIEEAGVHSGD 234
AV + + P+LIDKFL+N+IE+DVD+++D V+IG++MEHIEEAG+HSGD
Sbjct: 764 ELERYMTYAVQIEPDHPILIDKFLENAIEVDVDSLTDSTGKVVIGSIMEHIEEAGIHSGD 823
Query: 235 SATSIPPYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVP 294
SA SIP SLS ++ +++ T +LA AL V GL+N+QYAVQ ++VY+LE NPRASRTVP
Sbjct: 824 SACSIPYTSLSDNVLTTIRQWTEQLARALNVVGLMNIQYAVQGDQVYILEANPRASRTVP 883
Query: 295 FVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVF 354
+VSK+ G PLAKIA+ V GK+L E+ +F+P+ +VKE V
Sbjct: 884 YVSKATGRPLAKIASLVMSGKTLEEL-------------GVTEEFIPQH---VAVKEAVL 927
Query: 355 PWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKP 414
P+ +FP D +LGPEM+STGEVMGID +FG A+ KA+L AG L G +F+S++DR K
Sbjct: 928 PFSKFPGADTLLGPEMRSTGEVMGIDSDFGKAFAKAELGAGVILATTGTVFVSMSDRTKE 987
Query: 415 KILELAKEFEKLGFGIYATSGTYKFLKEHGV-NAKRVLKVSEGRPNVVDMIINGEIHLVI 473
+ + +E LGF + ATSGT K L+EHG+ + VLK+ EGRP+V+D I NG+I +I
Sbjct: 988 AAVPVVRELIDLGFKVVATSGTQKVLREHGIEGVEVVLKLHEGRPHVIDWIKNGQIQFII 1047
Query: 474 NTPSGKREKSDAYYIRRACVQFNVPYYTTMRAGYAVLEAIKSIK 517
NTPSG+ + D IRRA + + +P TT+ G A + A++S++
Sbjct: 1048 NTPSGEESQLDGRTIRRAALDYKLPIITTIAGGKATVAALRSLQ 1091
Score = 243 bits (614), Expect = 2e-63
Identities = 145/400 (36%), Positives = 235/400 (58%), Gaps = 23/400 (5%)
Query: 4 KVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEP 63
K++ILG+GP IGQ EFDY+ A +L+EEGY V+VN NP ++ TD + AD+ Y EP
Sbjct: 33 KIMILGAGPIVIGQACEFDYSGTQACKALKEEGYEVVLVNSNPASIMTDPELADRTYIEP 92
Query: 64 IVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKN------GVKILGTKPESIDKAED 117
++ E V IIE+E+P+ V+ GGQT L LA+ L K+ GV+++G K +I+ ED
Sbjct: 93 LIPEIVEKIIEKERPDAVLPTMGGQTALNLAVSLSKSGVLEKYGVELIGAKLPAIEMGED 152
Query: 118 RELFRELIIELGLKQPPSGTARTKEEALKIAKEIG-FPVLVRPSYVLGGRAMRIVYDXXX 176
RELF+E + +G+ PSG A + EEA ++A EIG +P+++RP++ L G I Y+
Sbjct: 153 RELFKEAMARIGVPVCPSGIASSIEEARQVAHEIGSYPLIIRPAFTLAGTGGGIAYNQEE 212
Query: 177 XXXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKD-VLIGAVMEHIEEAGVHSGDS 235
+ S +L++K L E +++ + D D V+I +E+ + GVH+GDS
Sbjct: 213 YEEMVQYGLDQSPMSQILVEKSLLGWKEYELEVMRDLADNVVIICSIENFDPMGVHTGDS 272
Query: 236 ATSIPPYSLSKEIVEEVKEQTRKLAVALEV---KGLINVQYAVQ--NNEVYVLEVNPRAS 290
T P +L+ + + +++ + +A+ E+ G N+Q++V N +V V+E+NPR S
Sbjct: 273 ITVAPAQTLTDKEYQRLRDYS--IAIIREIGVETGGSNIQFSVNPANGDVIVIEMNPRVS 330
Query: 291 RTVPFVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVK 350
R+ SK+ G+P+AK A K+A+G +L EI ++ ++ + F P + + K
Sbjct: 331 RSSALASKATGFPIAKFAAKLAVGYTLNEISNDITKKT-------PASFEPTIDYVVT-K 382
Query: 351 EVVFPWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKA 390
F +++FP +PIL +MKS GE M I + F ++ KA
Sbjct: 383 IPRFAFEKFPGAEPILNTQMKSVGEAMAIGRTFQESFQKA 422
gb|AAD35642.1|AE001730_10 (AE001730) carbamoyl-phosphate synthase, large subunit [Thermotoga
maritima]
Length = 1099
Score = 533 bits (1357), Expect = e-150
Identities = 286/542 (52%), Positives = 377/542 (68%), Gaps = 30/542 (5%)
Query: 3 KKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFE 62
+K++ILGSGPNRIGQGIEFDY VH V+S QEEGY +MVN NPETVSTDYDT+D+LYFE
Sbjct: 547 EKIMILGSGPNRIGQGIEFDYTNVHGVWSFQEEGYETIMVNSNPETVSTDYDTSDRLYFE 606
Query: 63 PIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFR 122
P+ E V++I+ EKP+GV++ FGGQTPLK+A L + V I+GT ESI+ AEDRE F
Sbjct: 607 PLTVEDVLEIVRNEKPKGVVVAFGGQTPLKIAKYLVEERVNIIGTSFESIEIAEDREKFA 666
Query: 123 ELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXX 182
+L+ ++GLK PP GTA + EEAL++A+ +G+PVLVRPSYVLGGRAM IV
Sbjct: 667 KLLKQIGLKCPPFGTASSVEEALRVAENLGYPVLVRPSYVLGGRAMAIVDTPQELEMYVK 726
Query: 183 XAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPY 242
A VS PVLIDKFL+++IELDVD VSDGK V I +ME IEEAGVHSGDSA +PP
Sbjct: 727 EAAVVSPGYPVLIDKFLEDAIELDVDVVSDGKYVWIAGLMEQIEEAGVHSGDSACVLPPV 786
Query: 243 SLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGY 302
SLS+++VEE++E KL AL+V G+ N+Q AV++ E+Y++E NPRASRTVPFVSK+IG
Sbjct: 787 SLSEKLVEEIEETVYKLVKALKVVGVANIQLAVKDEEIYIIEANPRASRTVPFVSKAIGI 846
Query: 303 PLAKIATKVAIGKSLREILPEVFE-------RLEK-GEAHFASDFLPKE-KKIFSVKEVV 353
P+A+IA K+ +G++L E+L E F +++K GE S+ LP K+FSVKEVV
Sbjct: 847 PVARIAAKIMVGRNLPELLSEYFPYPTRPGVKVDKLGE----SEILPTPWPKMFSVKEVV 902
Query: 354 FPWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDK 413
P+ +FP D +LGPEM+STGEVMGI ++F A+ KAQ++AG LP G + +VAD+DK
Sbjct: 903 IPFHKFPGTDVLLGPEMRSTGEVMGIGEDFAEAFAKAQIAAGNPLPTTGAILATVADKDK 962
Query: 414 PKILELAKEFEKLGFGIYATSGTYKFLKEHGVNAKRVLKVSEGRPNVVDMIINGEIHLVI 473
+ + L +GF IYAT GT K L+ HGV K V KV EGRP+V+D++ G+I LV+
Sbjct: 963 REAVPLLAHLADMGFEIYATRGTAKALQSHGVEVKVVPKVGEGRPDVIDLLEQGKISLVV 1022
Query: 474 NTPS-----------GKR------EKSDAYYIRRACVQFNVPYYTTMRAGYAVLEAIKSI 516
T S GK ++ Y IR ++ +PY TT+ + A + AI+ +
Sbjct: 1023 ITQSSDEPALVAVSHGKEPFKVEGRRTVGYMIRTTALKRKIPYLTTVESLRAAVAAIRKM 1082
Query: 517 KK 518
KK
Sbjct: 1083 KK 1084
Score = 232 bits (585), Expect = 6e-60
Identities = 139/398 (34%), Positives = 225/398 (55%), Gaps = 18/398 (4%)
Query: 3 KKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFE 62
K+++++GSGP IGQ EFDY+ A+ +L+ GY ++VN N T+ TD + +D +Y E
Sbjct: 8 KRILVIGSGPITIGQAAEFDYSGTQALKALKSAGYEVIIVNSNSATIMTDPEFSDAVYIE 67
Query: 63 PIVFEHVMDIIEREKPEGVILQFGGQTPLKLALP------LQKNGVKILGTKPESIDKAE 116
P+ E + IIE+E+P+ ++ GGQT L LA+ L K GV+++G K ESI KAE
Sbjct: 68 PLTVEFLEKIIEKERPDALLPTLGGQTALNLAVELAERGILDKYGVQLIGAKLESIKKAE 127
Query: 117 DRELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXX 176
DRELF+E + + GL+ S +AL+ A+E G+PV++RPS+ LGG I ++
Sbjct: 128 DRELFKETMEKAGLEVLRSRLVNNLADALETAREFGYPVIIRPSFTLGGTGGGIAFNEEE 187
Query: 177 XXXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGK-DVLIGAVMEHIEEAGVHSGDS 235
+ S VLI++ + E +++ V DG + ++ +E+++ G+H+GDS
Sbjct: 188 LRDIVTKGLIESPVHTVLIEESVLGWKEYELEVVRDGAGNFIVVCSIENLDPMGIHTGDS 247
Query: 236 ATSIPPYSLSKEIVEEVKEQTRKLAVALEVK-GLINVQYAV--QNNEVYVLEVNPRASRT 292
T P +L+ + +++ K+ A+ ++ G N+Q+A+ + + V+E+NPR SR+
Sbjct: 248 ITVAPAQTLTDVEYQRMRDAAYKVIDAIGIETGGSNIQFALDPETGRMVVIEMNPRVSRS 307
Query: 293 VPFVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEV 352
SK+ GYP+AK+A +A+G +L EI P + D++ VK
Sbjct: 308 SALASKATGYPIAKVAALLAVGFTLDEI-PNYITGKTMAAFEPSIDYV-------VVKIP 359
Query: 353 VFPWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKA 390
F ++FP DP L +MKS GEVM I + F A KA
Sbjct: 360 RFQLEKFPGADPRLNTQMKSVGEVMAIGRTFKEALGKA 397
gi|1477480 (U40341) carbamoyl phosphate synthetase large chain [Arabidopsis
thaliana]
Length = 1187
Score = 522 bits (1331), Expect = e-147
Identities = 272/551 (49%), Positives = 372/551 (67%), Gaps = 37/551 (6%)
Query: 3 KKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFE 62
KKV+ILG GPNRIGQGIEFDY C H F+LQ+ GY +M+N NPETVSTDYDT+D+LYFE
Sbjct: 650 KKVLILGGGPNRIGQGIEFDYCCCHTSFALQDAGYETIMLNSNPETVSTDYDTSDRLYFE 709
Query: 63 PIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQ-------------KNGVKILGTKP 109
P+ E V+++I+ EKP+G+I+QFGGQTPLKLALP++ V+I GT P
Sbjct: 710 PLTIEDVLNVIDLEKPDGIIVQFGGQTPLKLALPIKHYLDKHMPMSLSGAGPVRIWGTSP 769
Query: 110 ESIDKAEDRELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMR 169
+SID AEDRE F ++ EL ++QP G A+++ +AL IAKE+G+PV+VRPSYVLGGRAM
Sbjct: 770 DSIDAAEDRERFNAILDELKIEQPKGGIAKSEADALAIAKEVGYPVVVRPSYVLGGRAME 829
Query: 170 IVYDXXXXXXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDG-KDVLIGAVMEHIEEA 228
IVYD AV V ERPVL+DK+L ++IE+DVD ++D +V+IG +MEHIE+A
Sbjct: 830 IVYDDSRLITYLENAVQVDPERPVLVDKYLSDAIEIDVDTLTDSYGNVVIGGIMEHIEQA 889
Query: 229 GVHSGDSATSIPPYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAV-QNNEVYVLEVNP 287
GVHSGDSA +P ++ ++ ++ T KLA L V GL+N QYA+ + +V++LE NP
Sbjct: 890 GVHSGDSACMLPTQTIPASCLQTIRTWTTKLAKKLNVCGLMNCQYAITTSGDVFLLEANP 949
Query: 288 RASRTVPFVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIF 347
RASRTVPFVSK+IG+PLAK A V GKSL+++ +F + +PK
Sbjct: 950 RASRTVPFVSKAIGHPLAKYAALVMSGKSLKDL-------------NFEKEVIPKH---V 993
Query: 348 SVKEVVFPWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFIS 407
SVKE VFP+++F D ILGPEM+STGEVM I EF A+ AQ++AG +LP G +F+S
Sbjct: 994 SVKEAVFPFEKFQGCDVILGPEMRSTGEVMSISSEFSSAFAMAQIAAGQKLPLSGTVFLS 1053
Query: 408 VADRDKPKILELAKEFEKLGFGIYATSGTYKFLKEHGVNAKRVLKVSEGRPNVVDMIING 467
+ D KP + ++A F +LGF I ATSGT FL+ G+ +RVLK+ EGRP+ DM+ NG
Sbjct: 1054 LNDMTKPHLEKIAVSFLELGFKIVATSGTAHFLELKGIPVERVLKLHEGRPHAADMVANG 1113
Query: 468 EIHLVINTPSGKR-EKSDAYYIRRACVQFNVPYYTTMRAGYAVLEAIKSIKKLKEEGKGL 526
+IHL++ T SG ++ D +R+ + + VP TT+ A E IKS+K +
Sbjct: 1114 QIHLMLITSSGDALDQKDGRQLRQMALAYKVPVITTVAGALATAEGIKSLK-----SSAI 1168
Query: 527 SVHSLQEIYNI 537
+ +LQ+ + +
Sbjct: 1169 KMTALQDFFEV 1179
Score = 246 bits (621), Expect = 4e-64
Identities = 144/399 (36%), Positives = 236/399 (59%), Gaps = 19/399 (4%)
Query: 3 KKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFE 62
KK++ILG+GP IGQ EFDY+ A +L+EEGY +++N NP T+ TD +TA++ Y
Sbjct: 99 KKIMILGAGPIVIGQACEFDYSGTQACKALREEGYEVILINSNPATIMTDPETANRTYIA 158
Query: 63 PIVFEHVMDIIEREKPEGVILQFGGQTPLKLAL------PLQKNGVKILGTKPESIDKAE 116
P+ E V +IE+E+P+ ++ GGQT L LA+ L+K GV+++G K +I KAE
Sbjct: 159 PMTPELVEQVIEKERPDALLPTMGGQTALNLAVALAESGALEKYGVELIGAKLGAIKKAE 218
Query: 117 DRELFRELIIELGLKQPPSGTARTKEEALKIAKEIG-FPVLVRPSYVLGGRAMRIVYDXX 175
DRELF++ + +GLK PPSG T +E IA++IG FP+++RP++ LGG I Y+
Sbjct: 219 DRELFKDAMKNIGLKTPPSGIGTTLDECFDIAEKIGEFPLIIRPAFTLGGTGGGIAYNKE 278
Query: 176 XXXXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKD-VLIGAVMEHIEEAGVHSGD 234
++ S VL++K L E +++ + D D V+I +E+I+ GVH+GD
Sbjct: 279 EFESICKSGLAASATSQVLVEKSLLGWKEYELEVMRDLADNVVIICSIENIDPMGVHTGD 338
Query: 235 SATSIPPYSLSKEIVEEVKEQTRKLAVALEVK-GLINVQYAVQ--NNEVYVLEVNPRASR 291
S T P +L+ + +++ + + + V+ G NVQ+AV + EV ++E+NPR SR
Sbjct: 339 SITVAPAQTLTDREYQRLRDYSIAIIREIGVECGGSNVQFAVNPVDGEVMIIEMNPRVSR 398
Query: 292 TVPFVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKE 351
+ SK+ G+P+AK+A K+++G +L +I ++ + + F P + + K
Sbjct: 399 SSALASKATGFPIAKMAAKLSVGYTLDQIPNDITRKT-------PASFEPSIDYVVT-KI 450
Query: 352 VVFPWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKA 390
F +++FP P+L +MKS GE M + + F ++ KA
Sbjct: 451 PRFAFEKFPGSQPLLTTQMKSVGESMALGRTFQESFQKA 489
gi|3820584 (AF086791) carbamoylphosphate synthetase large subunit [Zymomonas
mobilis]
Length = 1092
Score = 521 bits (1327), Expect = e-147
Identities = 276/535 (51%), Positives = 364/535 (67%), Gaps = 39/535 (7%)
Query: 3 KKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFE 62
KKVVILG GPNRIGQG+EFDY C HA F+L+ GY +MVNCNPETVSTDYDT+D+LYFE
Sbjct: 590 KKVVILGGGPNRIGQGLEFDYCCCHACFALEAAGYETIMVNCNPETVSTDYDTSDRLYFE 649
Query: 63 PIVFEHVMDIIEREKPEG----VILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDR 118
P+ E V++I+ E+ G VI+QFGGQTPLKLA ++K G+ ILGT P++ID AEDR
Sbjct: 650 PLTGEDVLEILHTEQKNGTLVGVIVQFGGQTPLKLAAEIEKAGIPILGTSPDAIDLAEDR 709
Query: 119 ELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXX 178
E F L+ ELGL QP +G AR+++EA+ +A +IG+P+L+RPSYVLGGRAM I+
Sbjct: 710 ERFSALVSELGLLQPANGIARSRDEAISVADKIGYPILIRPSYVLGGRAMEIIDGPSQLD 769
Query: 179 XXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATS 238
AV VS E PVLID++L ++ E+DVDAV+DG DV++ +++HIEEAG+HSGDSA S
Sbjct: 770 DYIHTAVKVSGESPVLIDQYLRDATEVDVDAVADGDDVVVAGILQHIEEAGIHSGDSACS 829
Query: 239 IPPYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSK 298
IPPYSL I+EE+K QT KLA AL+V+GL+N+Q+AV+ ++VY++EVNPRASRTVPFV+K
Sbjct: 830 IPPYSLPASIIEEIKSQTDKLARALKVQGLMNIQFAVKGDKVYLIEVNPRASRTVPFVAK 889
Query: 299 SIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKR 358
+ G P+A++A +V G+ LR LPE+ E + A VKE VFPW R
Sbjct: 890 ADGRPVAQVAARVMAGEKLRN-LPEI----SWPEGYTA------------VKEAVFPWAR 932
Query: 359 FPEVDPILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILE 418
FP G+D +F +A+ KAQL+AG LP G FISV D DK +I+E
Sbjct: 933 FP-----------------GVDIDFPMAFAKAQLAAGNALPRAGTFFISVKDSDKAQIVE 975
Query: 419 LAKEFEKLGFGIYATSGTYKFLKEHGVNAKRVLKVSEGRPNVVDMIINGEIHLVINTPSG 478
K LG + AT GT ++L+ GV +RV KV EGRP++VD+I +G I LV+NT G
Sbjct: 976 PIKALTDLGIKLVATDGTARYLQSKGVPVERVNKVREGRPHIVDLIKDGAISLVVNTTEG 1035
Query: 479 KREKSDAYYIRRACVQFNVPYYTTMRAGYAVLEAIKSIKKLKEEGKGL-SVHSLQ 532
+ D+ IR + V VPY+TT A EAI +IK + E + L S HS++
Sbjct: 1036 WQSLQDSASIRSSVVLAPVPYFTTAAAAIVAAEAIVAIKARELEVRSLQSYHSMK 1090
Score = 225 bits (567), Expect = 8e-58
Identities = 142/400 (35%), Positives = 223/400 (55%), Gaps = 23/400 (5%)
Query: 3 KKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFE 62
+ ++I+G+GP IGQ EFDY+ A +L+EEGY ++VN NP T+ TD D AD Y E
Sbjct: 8 QSIMIIGAGPIVIGQACEFDYSGTQACKALREEGYRVILVNSNPATIMTDPDMADATYIE 67
Query: 63 PIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGV------KILGTKPESIDKAE 116
PI E V IIE+E+P+ ++ GGQT L AL L +G +++G +IDKAE
Sbjct: 68 PITPEVVARIIEKERPDALLPTMGGQTALNTALALASDGTLEKFNCEMIGADATAIDKAE 127
Query: 117 DRELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXX 176
DR FR+ + ++GL+ P S A + EEAL + P ++RPS+ +GG + Y+
Sbjct: 128 DRLKFRQAMDKIGLESPRSSVAHSLEEALD-GLDYVLPAIIRPSFTMGGTGGGVAYNKEE 186
Query: 177 XXXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKD-VLIGAVMEHIEEAGVHSGDS 235
+S S + VLI++ + E +++ V D D +I +E+I+ GVH+GDS
Sbjct: 187 FIDIVSGGLSASPTQEVLIEESVIGWKEYEMEVVRDRHDNCIIICSIENIDPMGVHTGDS 246
Query: 236 ATSIPPYSLSKEIVEEVKEQTRKLAVALEV---KGLINVQYAV--QNNEVYVLEVNPRAS 290
T P +++ + + ++ + +AV E+ G NVQ+A+ +N + V+E+NPR S
Sbjct: 247 ITVAPALTMTDKEYQIMRNAS--IAVLREIGVETGGSNVQFALNPENGRLVVIEMNPRVS 304
Query: 291 RTVPFVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVK 350
R+ SK+ G+P+AK+ATK+AIG +L EI ++ + F P + + K
Sbjct: 305 RSSALASKATGFPIAKVATKLAIGYTLDEITNDI-------TGATPASFEPTIDYVVT-K 356
Query: 351 EVVFPWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKA 390
F +++F P+L MKS GEVM I + F + KA
Sbjct: 357 IPRFAFEKFKNAKPLLTTAMKSVGEVMAIGRSFPESLQKA 396
emb|CAB44435.1| (AJ242913) carbamoylphosphate synthase (large subunit) [Klebsiella
aerogenes]
Length = 481
Score = 514 bits (1309), Expect = e-145
Identities = 256/482 (53%), Positives = 349/482 (72%), Gaps = 16/482 (3%)
Query: 20 EFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEPIVFEHVMDIIEREKPE 79
EFDY CVHA +L+E+GY +MVNCNPETVSTDYDT+D+LYFEP+ E V++I+ EKP+
Sbjct: 1 EFDYCCVHASLALREDGYETIMVNCNPETVSTDYDTSDRLYFEPVTLEDVLEIVHIEKPK 60
Query: 80 GVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFRELIIELGLKQPPSGTAR 139
GVI+Q+GGQTPLKLA L+ GV ++GT P++ID+AEDRE F+ + L LKQP + T
Sbjct: 61 GVIVQYGGQTPLKLARALEAAGVPVIGTSPDAIDRAEDRERFQHAVDRLKLKQPANATVT 120
Query: 140 TKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXXXAVSVSHERPVLIDKFL 199
E+A++ AKEIG+P++VRPSYVLGGRAM IVYD AVSVS++ PVL+D+FL
Sbjct: 121 AIEQAVEKAKEIGYPLVVRPSYVLGGRAMEIVYDEQDLRRYFQTAVSVSNDAPVLLDRFL 180
Query: 200 DNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPYSLSKEIVEEVKEQTRKL 259
D++IE+DVDA+ DG+ VLIG +MEHIE+AGVHSGDSA S+P Y+LSKEI + ++EQ +KL
Sbjct: 181 DDAIEVDVDAICDGEMVLIGGIMEHIEQAGVHSGDSACSLPAYTLSKEIQDVMREQVQKL 240
Query: 260 AVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGYPLAKIATKVAIGKSLRE 319
A L+V+GL+NVQ+AV++NEVY++EVNPRA+RTVPFVSK+ G PLAK+A +V GK+L
Sbjct: 241 AFELQVRGLMNVQFAVKDNEVYLIEVNPRAARTVPFVSKATGVPLAKVAARVMAGKTL-- 298
Query: 320 ILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEVDPILGPEMKSTGEVMGI 379
+ + +P +SVKEVV P+ +FP VDP+LGPEM+STGEVMG+
Sbjct: 299 -----------AQQGVTKEIIP---PYYSVKEVVLPFNKFPGVDPLLGPEMRSTGEVMGV 344
Query: 380 DKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILELAKEFEKLGFGIYATSGTYKF 439
+ F A+ KAQL + + ++ +SV + DK ++++LA + K GF + AT GT
Sbjct: 345 GRTFAEAFAKAQLGSNSTMKKQVRALLSVREGDKERVVDLAAKLLKFGFELDATHGTAIV 404
Query: 440 LKEHGVNAKRVLKVSEGRPNVVDMIINGEIHLVINTPSGKREKSDAYYIRRACVQFNVPY 499
L E G+N + V KV EGRP++ D I NGE +INT +G++ D+ IRR+ +Q+ V Y
Sbjct: 405 LGEAGINPRLVNKVHEGRPHIQDRIKNGEYTYIINTTAGRQAIEDSKLIRRSALQYKVHY 464
Query: 500 YT 501
T
Sbjct: 465 DT 466
pdb|1A9X|A Chain A, Carbamoyl Phosphate Synthetase: Caught In The Act Of
Glutamine Hydrolysis >gi|3891749|pdb|1A9X|C Chain C,
Carbamoyl Phosphate Synthetase: Caught In The Act Of
Glutamine Hydrolysis >gi|3891751|pdb|1A9X|E Chain E,
Carbamoyl Phosphate Synthetase: Caught In The Act Of
Glutamine Hydrolysis >gi|3891753|pdb|1A9X|G Chain G,
Carbamoyl Phosphate Synthetase: Caught In The Act Of
Glutamine Hydrolysis
Length = 1058
Score = 513 bits (1307), Expect = e-144
Identities = 262/513 (51%), Positives = 356/513 (69%), Gaps = 31/513 (6%)
Query: 3 KKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFE 62
+K+++LG GPNRIGQGIEFDY CVHA +L+E+GY +MVNCNPETVSTDYDT+D+LYFE
Sbjct: 560 EKIMVLGGGPNRIGQGIEFDYCCVHASLALREDGYETIMVNCNPETVSTDYDTSDRLYFE 619
Query: 63 PIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFR 122
P+ E V++I+ EKP+GVI+Q+GGQTPLKLA L+ GV ++GT P++ID+AEDRE F+
Sbjct: 620 PVTLEDVLEIVRIEKPKGVIVQYGGQTPLKLARALEAAGVPVIGTSPDAIDRAEDRERFQ 679
Query: 123 ELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXX 182
+ L LKQP + T E A++ AKEIG+P++VR AM IVYD
Sbjct: 680 HAVERLKLKQPANATVTAIEMAVEKAKEIGYPLVVR-------AAMEIVYDEADLRRYFQ 732
Query: 183 XAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPY 242
A VL+D FLD+++E+DVDA+ DG+ VLIG +MEHIE+AGVHSGDSA S+P Y
Sbjct: 733 TA--------VLLDHFLDDAVEVDVDAICDGEMVLIGGIMEHIEQAGVHSGDSACSLPAY 784
Query: 243 SLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGY 302
+LS+EI + +++Q +KLA L+V+GL+NVQ+AV+NNEVY++EVNPRA+RTVPFVSK+ G
Sbjct: 785 TLSQEIQDVMRQQVQKLAFELQVRGLMNVQFAVKNNEVYLIEVNPRAARTVPFVSKATGV 844
Query: 303 PLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEV 362
PLAK+A +V GKSL E + +P +SVKEVV P+ +FP V
Sbjct: 845 PLAKVAARVMAGKSL-------------AEQGVTKEVIP---PYYSVKEVVLPFNKFPGV 888
Query: 363 DPILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILELAKE 422
DP+LGPEM+STGEVMG+ + F A+ KAQL + + + G +SV + DK ++++LA +
Sbjct: 889 DPLLGPEMRSTGEVMGVGRTFAEAFAKAQLGSNSTMKKHGRALLSVREGDKERVVDLAAK 948
Query: 423 FEKLGFGIYATSGTYKFLKEHGVNAKRVLKVSEGRPNVVDMIINGEIHLVINTPSGKREK 482
K GF + AT GT L E G+N + V KV EGRP++ D I NGE +INT SG+R
Sbjct: 949 LLKQGFELDATHGTAIVLGEAGINPRLVNKVHEGRPHIQDRIKNGEYTYIINTTSGRRAI 1008
Query: 483 SDAYYIRRACVQFNVPYYTTMRAGYAVLEAIKS 515
D+ IRR+ +Q+ V Y TT+ G+A A+ +
Sbjct: 1009 EDSRVIRRSALQYKVHYDTTLNGGFATAMALNA 1041
Score = 234 bits (591), Expect = 1e-60
Identities = 141/391 (36%), Positives = 222/391 (56%), Gaps = 21/391 (5%)
Query: 3 KKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFE 62
K ++ILG+GP IGQ EFDY+ A +L+EEGY + VN NP T+ TD + AD Y E
Sbjct: 8 KSILILGAGPIVIGQACEFDYSGAQACKALREEGYRVINVNSNPATIMTDPEMADATYIE 67
Query: 63 PIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKN------GVKILGTKPESIDKAE 116
PI +E V IIE+E+P+ V+ GGQT L AL L++ GV ++G ++IDKAE
Sbjct: 68 PIHWEVVRKIIEKERPDAVLPTMGGQTALNCALELERQGVLEEFGVTMIGATADAIDKAE 127
Query: 117 DRELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXX 176
DR F + ++GL+ SG A T EEAL +A ++GFP ++RPS+ +GG I Y+
Sbjct: 128 DRRRFDVAMKKIGLETARSGIAHTMEEALAVAADVGFPCIIRPSFTMGGSGGGIAYNREE 187
Query: 177 XXXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKD-VLIGAVMEHIEEAGVHSGDS 235
+ +S + +LID+ L E +++ V D D +I +E+ + G+H+GDS
Sbjct: 188 FEEICARGLDLSPTKELLIDESLIGWKEYEMEVVRDKNDNCIIVCSIENFDAMGIHTGDS 247
Query: 236 ATSIPPYSLSKEIVEEVKEQTRKLAVALEV---KGLINVQYAV--QNNEVYVLEVNPRAS 290
T P +L+ + + ++ + +AV E+ G NVQ+AV +N + V+E+NPR S
Sbjct: 248 ITVAPAQTLTDKEYQIMRNAS--MAVLREIGVETGGSNVQFAVNPKNGRLIVIEMNPRVS 305
Query: 291 RTVPFVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVK 350
R+ SK+ G+P+AK+A K+A+G +L E++ ++ + D++ K
Sbjct: 306 RSSALASKATGFPIAKVAAKLAVGYTLDELMNDITGGRTPASFEPSIDYV-------VTK 358
Query: 351 EVVFPWKRFPEVDPILGPEMKSTGEVMGIDK 381
F +++F + L +MKS GEVM I +
Sbjct: 359 IPRFNFEKFAGANDRLTTQMKSVGEVMAIGR 389
gi|4155424 (AE001514) CARBAMOYL-PHOSPHATE SYNTHASE LARGE CHAIN [Helicobacter
pylori J99]
Length = 1085
Score = 495 bits (1261), Expect = e-139
Identities = 256/515 (49%), Positives = 362/515 (69%), Gaps = 7/515 (1%)
Query: 3 KKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFE 62
KK++I+GSGPNRIGQGIEFDY CVHA F+L++ +VM+NCNPETVSTDYDT+D LYFE
Sbjct: 559 KKILIIGSGPNRIGQGIEFDYCCVHASFALKDLNIKSVMLNCNPETVSTDYDTSDTLYFE 618
Query: 63 PIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFR 122
PI FE V II+RE+ +G+I+ FGGQTPLKLA L K I+GT + ID AEDRE F
Sbjct: 619 PIHFECVKSIIQRERVDGIIVHFGGQTPLKLAKDLAKMQAPIIGTPFKVIDIAEDREKFS 678
Query: 123 ELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRI---VYDXXXXXX 179
+ EL +KQP +G A++ +EA IA IGFP++VRPSYVLGG+ M+I + +
Sbjct: 679 LFLKELDIKQPENGMAKSVDEAYSIANAIGFPIIVRPSYVLGGQHMQILENIEELRHYLE 738
Query: 180 XXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSI 239
++ +S + P+LIDKFL+ ++ELDVDA+ D K+V I +++HIEEAG+HSGDSA I
Sbjct: 739 SVTHSLEISPKNPLLIDKFLEKAVELDVDAICDKKEVYIAGILQHIEEAGIHSGDSACFI 798
Query: 240 PPYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKS 299
P +LS EI++E++ + K+A+ L V GL+N+Q+AV N +Y++EVNPRASRTVPF+SK+
Sbjct: 799 PS-TLSPEILDEIERVSAKIALHLGVVGLLNIQFAVYQNSLYLIEVNPRASRTVPFLSKA 857
Query: 300 IGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRF 359
+G PLAK+AT+V + + L+E L F + + + PK ++KE VFP+ +
Sbjct: 858 LGVPLAKVATRVMVLEDLKEALK--FYDKKNIVEYSKGVYKPKMPHFVALKEAVFPFNKL 915
Query: 360 PEVDPILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILEL 419
D ILGPEMKSTGEVMGI + GLA++KAQ + + KG +F+S+ D+DK + L
Sbjct: 916 YGSDLILGPEMKSTGEVMGIARSLGLAFFKAQTACFNPIKNKGLIFVSIKDKDKEEACVL 975
Query: 420 AKEFEKLGFGIYATSGTYKFLKEHGVNAKRVLKVSEGRPNVVDMIINGEIHLVINTPSGK 479
K +LGF + T GT+K L++ GV + +VLK+SEGRPN++D+++NGEI + INT S
Sbjct: 976 MKRLVELGFELCTTEGTHKALEKAGVKSLKVLKISEGRPNIMDLMMNGEISMAINT-SDH 1034
Query: 480 REKSDAYYIRRACVQFNVPYYTTMRAGYAVLEAIK 514
+ + DA IR + ++ +V Y+TT+ A +L A++
Sbjct: 1035 KSQDDAKLIRASVLKNHVSYFTTLSAIEVLLLALE 1069
Score = 221 bits (557), Expect = 1e-56
Identities = 136/399 (34%), Positives = 222/399 (55%), Gaps = 21/399 (5%)
Query: 5 VVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEPI 64
++++GSGP IGQ EFDY+ + +L+ GY +++N NP TV TD + + + Y +PI
Sbjct: 10 ILLIGSGPIVIGQACEFDYSGTQSCKTLKSLGYRVILINSNPATVMTDPEFSHQTYIQPI 69
Query: 65 VFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQK----NGVKILGTKPESIDKAEDREL 120
E++ II++EK + ++ GGQT L + + + GV++LG K E+I K EDR+
Sbjct: 70 TPENIAAIIKKEKIDAILPTMGGQTALNAVMQMHQRGMLEGVELLGAKIEAIKKGEDRQA 129
Query: 121 FRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXX 180
F+E ++++G+ P A ++ EAL+ EIGFP ++R S+ L G + Y+
Sbjct: 130 FKEAMLKIGMDLPKGRYAYSELEALEAISEIGFPAIIRASFTLAGGGSGVAYNIEEFQEL 189
Query: 181 XXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKD-VLIGAVMEHIEEAGVHSGDSATSI 239
A+ S +LI++ L E +++ + DGKD +I +E+I+ GVH+GDS T
Sbjct: 190 AKNALDASPINEILIEESLLGWKEYEMEVIRDGKDNCIIVCCIENIDPMGVHTGDSITIA 249
Query: 240 PPYSLSKEIVEEVKEQTRKLAVALEV---KGLINVQYAV--QNNEVYVLEVNPRASRTVP 294
P +L+ + + +++ + A+ E+ G NVQ+A+ + + V+E+NPR SR+
Sbjct: 250 PSLTLTDKEYQRMRDAS--FAILREIGVDTGGSNVQFAIHPETLRMVVIEMNPRVSRSSA 307
Query: 295 FVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVF 354
SK+ G+P+AK+AT +A+G SL EI ++ + + F P I VK F
Sbjct: 308 LASKATGFPIAKVATMLAVGFSLDEIKNDI--------TNTPASFEPSLDYIV-VKIPRF 358
Query: 355 PWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKAQLS 393
+++F V LG MKS GEVM I F A KA S
Sbjct: 359 AFEKFAGVSSTLGTSMKSIGEVMAIGGNFLEALQKALCS 397
gb|AAD07963.1| (AE000601) carbamoyl-phosphate synthase (glutamine-hydrolysing)
(pyrAb) [Helicobacter pylori 26695]
Length = 1085
Score = 495 bits (1261), Expect = e-139
Identities = 258/522 (49%), Positives = 362/522 (68%), Gaps = 7/522 (1%)
Query: 3 KKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFE 62
KK++I+GSGPNRIGQGIEFDY CVHA +L++ +VM NCNPETVSTDYDT+D LYFE
Sbjct: 559 KKILIIGSGPNRIGQGIEFDYCCVHASLALKDLNIKSVMFNCNPETVSTDYDTSDTLYFE 618
Query: 63 PIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFR 122
PI FE V II+RE+ +G+I+ FGGQTPLKLA L K I+GT + ID AEDRE F
Sbjct: 619 PIHFECVKSIIQRERVDGIIVHFGGQTPLKLAKDLAKMQAPIIGTPFKVIDIAEDREKFS 678
Query: 123 ELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRI---VYDXXXXXX 179
+ EL +KQP +G A++ +EA IA IGFP++VRPSYVLGG+ M+I + +
Sbjct: 679 LFLKELDIKQPKNGMAKSVDEAYSIANVIGFPIIVRPSYVLGGQHMQILENIEELRHYLE 738
Query: 180 XXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSI 239
A+ +S + P+LIDKFL+ ++ELDVDA+ D K+V I +++HIEEAG+HSGDSA I
Sbjct: 739 SVTHALEISPKNPLLIDKFLEKAVELDVDAICDKKEVYIAGILQHIEEAGIHSGDSACFI 798
Query: 240 PPYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKS 299
P +LS EI++E++ + K+A+ L V GL+N+Q+AV N +Y++EVNPRASRTVPF+SK+
Sbjct: 799 PS-TLSPEILDEIERVSAKIALHLGVVGLLNIQFAVHQNSLYLIEVNPRASRTVPFLSKA 857
Query: 300 IGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRF 359
+G PLAK+AT+V + + L+E L F + + + PK ++KE VFP+ +
Sbjct: 858 LGVPLAKVATRVMVLEDLKEALK--FYDKKNIVGYSKGVYKPKMPHFVALKEAVFPFNKL 915
Query: 360 PEVDPILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILEL 419
D ILGPEMKSTGEVMGI + GLA++KAQ + + KG +F+S+ D+DK + L
Sbjct: 916 YGSDLILGPEMKSTGEVMGIARSLGLAFFKAQTACFNPIKNKGLIFVSIKDKDKEEACVL 975
Query: 420 AKEFEKLGFGIYATSGTYKFLKEHGVNAKRVLKVSEGRPNVVDMIINGEIHLVINTPSGK 479
K +LGF + AT GT+K L++ GV + +VLK+SEGRPN++D+++NGEI + INT S
Sbjct: 976 MKRLVQLGFELCATEGTHKALEKAGVKSLKVLKISEGRPNIMDLMMNGEISMAINT-SDH 1034
Query: 480 REKSDAYYIRRACVQFNVPYYTTMRAGYAVLEAIKSIKKLKE 521
+ + DA IR + ++ +V Y+TT+ +L A++ K E
Sbjct: 1035 KSQDDAKLIRASVLKNHVSYFTTLSTIEVLLLALEESSKEDE 1076
Score = 222 bits (560), Expect = 5e-57
Identities = 137/399 (34%), Positives = 221/399 (55%), Gaps = 21/399 (5%)
Query: 5 VVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEPI 64
++++GSGP IGQ EFDY+ + +L+ GY +++N NP TV TD + + + Y +PI
Sbjct: 10 ILLIGSGPIVIGQACEFDYSGTQSCKTLKSLGYRVILINSNPATVMTDPEFSHQTYIQPI 69
Query: 65 VFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQK----NGVKILGTKPESIDKAEDREL 120
E++ IIE+EK + ++ GGQT L + + + GV++LG K E+I K EDR+
Sbjct: 70 TPENIATIIEKEKIDAILPTMGGQTALNAVMQMHQKGMLEGVELLGAKIEAIKKGEDRQA 129
Query: 121 FRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXX 180
F+E ++++G+ P A T+ EAL+ EIGFP ++R S+ L G + Y+
Sbjct: 130 FKEAMLKIGMDLPKGRYAYTELEALEAINEIGFPAIIRASFTLAGGGSGVAYNIEEFQEL 189
Query: 181 XXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKD-VLIGAVMEHIEEAGVHSGDSATSI 239
A+ S +LI++ L E +++ + D KD +I +E+I+ GVH+GDS T
Sbjct: 190 AKNALDASPINEILIEESLLGWKEYEMEVIRDSKDNCIIVCCIENIDPMGVHTGDSITIA 249
Query: 240 PPYSLSKEIVEEVKEQTRKLAVALEV---KGLINVQYAV--QNNEVYVLEVNPRASRTVP 294
P +L+ + + +++ + A+ E+ G NVQ+A+ + + V+E+NPR SR+
Sbjct: 250 PSLTLTDKEYQRMRDAS--FAILREIGVDTGGSNVQFAIHPETLRMVVIEMNPRVSRSSA 307
Query: 295 FVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVF 354
SK+ G+P+AK+AT +A+G SL EI ++ + + F P I VK F
Sbjct: 308 LASKATGFPIAKVATMLAVGFSLDEIQNDI--------TNTPASFEPSLDYIV-VKIPRF 358
Query: 355 PWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKAQLS 393
+++F V LG MKS GEVM I F A KA S
Sbjct: 359 AFEKFAGVSSTLGTSMKSIGEVMAIGGNFLEALQKALCS 397
gi|533532 (U11295) carbamoyl phosphate synthetase (glutamine) large subunit
[Neisseria gonorrhoeae]
Length = 1079
Score = 480 bits (1221), Expect = e-134
Identities = 238/427 (55%), Positives = 314/427 (72%), Gaps = 16/427 (3%)
Query: 3 KKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFE 62
KKV+ILG+GPN IGQGIEFDY VHA L+E G+ +MVNCNPETVSTD+DT+D+LYFE
Sbjct: 557 KKVMILGAGPNPIGQGIEFDYCSVHAALPLRESGFETIMVNCNPETVSTDFDTSDRLYFE 616
Query: 63 PIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFR 122
P+ E V++I+ E P GVI+ +GGQTPLKLA L +NGV I+GT +SID AEDRE F+
Sbjct: 617 PLTLEDVLEIVRTENPWGVIVHYGGQTPLKLANALVENGVNIIGTSADSIDAAEDRERFQ 676
Query: 123 ELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXX 182
+++ +LGL+QPP+ A +EEAL A+EIG+P++VRPSYVLGG AM+IV+
Sbjct: 677 KVLNDLGLRQPPNRIAHNEEEALVKAEEIGYPLVVRPSYVLGGPAMQIVHSAEALQKYMR 736
Query: 183 XAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPY 242
V VS + PVL+D FL+N+IE+DVD VSDGKDV+IG +M+H+E+AG+HSGDS S+PPY
Sbjct: 737 EPVQVSEDSPVLLDFFLNNAIEVDVDCVSDGKDVVIGGIMQHVEQAGIHSGDSGCSLPPY 796
Query: 243 SLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGY 302
SLS+EI +E++ QT+ +A AL + GL+NVQ+AVQ+ V+VLEVNPRA+RTVPFVSK+ G
Sbjct: 797 SLSEEIQDEIRRQTKAMAYALGLVGLMNVQFAVQDAVVFVLEVNPRATRTVPFVSKATGQ 856
Query: 303 PLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEV 362
LAK+ + G SL+E + E DF ++VKE VFP+ +FP V
Sbjct: 857 RLAKVGARCMAGISLKE---------QGVEKEVVPDF-------YAVKEAVFPFIKFPGV 900
Query: 363 DPILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILELAKE 422
D IL PEM+STGEVMG+ + FG AYYKAQL AG RL G +F+SV + DK ++++ AK
Sbjct: 901 DTILNPEMRSTGEVMGVGRSFGEAYYKAQLGAGERLNPTGKIFLSVREEDKERVIKTAKN 960
Query: 423 FEKLGFG 429
F+ LG+G
Sbjct: 961 FQALGYG 967
Score = 203 bits (511), Expect = 3e-51
Identities = 131/401 (32%), Positives = 211/401 (51%), Gaps = 22/401 (5%)
Query: 3 KKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFE 62
K ++I+G+GP IGQ EFDY+ A +L+EEGY ++VN NP T+ TD + AD Y E
Sbjct: 8 KSILIIGAGPIVIGQACEFDYSGAQACKALREEGYKVILVNSNPATIMTDPEMADVTYIE 67
Query: 63 PIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNG------VKILGTKPESIDKAE 116
PI+++ V II +E+P+ ++ GG L AL L NG V+++G ++IDKAE
Sbjct: 68 PIMWQTVEKIIAKERPDAILPTMGGTDRLNCALDLAGNGVLAKYDVELIGATEDAIDKAE 127
Query: 117 DRELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXX 176
D F+E + ++GL P S T EAL +++GFP L+RPS+ +GG I Y+
Sbjct: 128 DPGRFKEAMEKIGLSCPKSLFCHTMNEALAAQEQVGFPTLIRPSFTMGGSGGGIAYNKDE 187
Query: 177 XXXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKD-VLIGAVMEHIEEAGVHSGDS 235
S +LI++ + E +++ V D D +I +E+ + GVH+GDS
Sbjct: 188 FLAICERGFDASPTHELLIEQSVLGWKEYEMEVVRDKADNCIIICSIENFDPMGVHTGDS 247
Query: 236 ATSIPPYSLSKEIVEEVKEQTRKLAVALEV---KGLINVQYAV---QNNEVYVLEVNPRA 289
T P +L+ + + ++ + LAV E+ G NVQ+AV + + +
Sbjct: 248 ITVAPAETLTDKEYQIMRNAS--LAVLREIGVDTGGSNVQFAVNPEKRRDDCDRDEPAAV 305
Query: 290 SRTVPFVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSV 349
SR+ SK+ G+P+AK+A A+G +L E+ ++ R + D++
Sbjct: 306 SRSSALASKATGFPIAKVAANWAVGFTLDELRNDITGRRTPASFEPSIDYV-------VT 358
Query: 350 KEVVFPWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKA 390
K F +++FP D L +MKS GEVM + + ++ KA
Sbjct: 359 KMARFAFEKFPAADDRLTTQMKSVGEVMAMGRTIQESFQKA 399
sp|P25994|CARB_BACSU CARBAMOYL-PHOSPHATE SYNTHASE, PYRIMIDINE-SPECIFIC, LARGE CHAIN
(CARBAMOYL-PHOSPHATE SYNTHETASE AMMONIA CHAIN)
>gi|98246|pir||F39845 carbamoyl-phosphate synthase
(glutamine-hydrolyzing) (EC 6.3.5.5),
pyrimidine-repressible, large chain - Bacillus subtilis
>gi|143390|gb|AAA21270.1| (M59757) carbamyl phosphate
synthetase [Bacillus subtilis] >gi|2633925|emb|CAB13426|
(Z99112) carbamoyl-phosphate synthetase (catalytic
subunit) [Bacillus subtilis]
Length = 1071
Score = 471 bits (1199), Expect = e-132
Identities = 246/515 (47%), Positives = 343/515 (65%), Gaps = 16/515 (3%)
Query: 3 KKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFE 62
K V++LGSGP RIGQG+EFDYA VH+V+++++ GY A++VN NPETVSTD+ +DKLYFE
Sbjct: 552 KSVMVLGSGPIRIGQGVEFDYATVHSVWAIKQAGYEAIIVNNNPETVSTDFSISDKLYFE 611
Query: 63 PIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFR 122
P+ E VM II+ E+P GV++QFGGQT + LA L GVKILGT E +D+AEDR+ F
Sbjct: 612 PLTIEDVMHIIDLEQPMGVVVQFGGQTAINLADELSARGVKILGTSLEDLDRAEDRDKFE 671
Query: 123 ELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXX 182
+ + ELG+ QP TA + +A+ IA +IG+PVLVRPSYVLGGRAM IVY
Sbjct: 672 QALGELGVPQPLGKTATSVNQAVSIASDIGYPVLVRPSYVLGGRAMEIVYHEEELLHYMK 731
Query: 183 XAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPY 242
AV ++ + PVLID++L E++VDAVSDG+ V+I +MEHIE AGVHSGDS PP
Sbjct: 732 NAVKINPQHPVLIDRYLTGK-EIEVDAVSDGETVVIPGIMEHIERAGVHSGDSIAVYPPQ 790
Query: 243 SLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGY 302
SL+++I +++++ T LA L + GL+N+Q+ + EVYVLEVNPR+SRTVPF+SK G
Sbjct: 791 SLTEDIKKKIEQYTIALAKGLNIVGLLNIQFVLSQGEVYVLEVNPRSSRTVPFLSKITGI 850
Query: 303 PLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEV 362
P+A +ATK+ +G+ L + P+++ +F VK VF + + V
Sbjct: 851 PMANLATKIILGQKLAAF-------------GYTEGLQPEQQGVF-VKAPVFSFAKLRRV 896
Query: 363 DPILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILELAKE 422
D LGPEMKSTGEVMG D A YKA +++G ++P G++ ++VAD+DK + L +AK
Sbjct: 897 DITLGPEMKSTGEVMGKDSTLEKALYKALIASGIQIPNYGSVLLTVADKDKEEGLAIAKR 956
Query: 423 FEKLGFGIYATSGTYKFLKEHGVNAKRVLKVSEGRPNVVDMIINGEIHLVINT-PSGKRE 481
F +G+ I AT GT +LKE + AK V K+ + PN++D+I NGE VINT GK+
Sbjct: 957 FHAIGYNILATEGTAGYLKEASIPAKVVGKIGQDGPNLLDVIRNGEAQFVINTLTKGKQP 1016
Query: 482 KSDAYYIRRACVQFNVPYYTTMRAGYAVLEAIKSI 516
D + IRR V+ V T++ A+L ++S+
Sbjct: 1017 ARDGFRIRRESVENGVACLTSLDTAEAILRVLESM 1051
Score = 252 bits (637), Expect = 5e-66
Identities = 149/396 (37%), Positives = 228/396 (56%), Gaps = 17/396 (4%)
Query: 4 KVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEP 63
K++++GSGP IGQ EFDYA A +L+EEGY ++VN NP T+ TD + AD++Y EP
Sbjct: 9 KILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYEVILVNSNPATIMTDTEMADRVYIEP 68
Query: 64 IVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKN------GVKILGTKPESIDKAED 117
+ E + II +E+P+ ++ GGQT L LA+ L + GV++LGTK +I +AED
Sbjct: 69 LTPEFLTRIIRKERPDAILPTLGGQTGLNLAVELSERGVLAECGVEVLGTKLSAIQQAED 128
Query: 118 RELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXX 177
R+LFR L+ EL P S + EEA K +IGFPV+VRP+Y LGG I +
Sbjct: 129 RDLFRTLMNELNEPVPESEIIHSLEEAEKFVSQIGFPVIVRPAYTLGGTGGGICSNETEL 188
Query: 178 XXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKD-VLIGAVMEHIEEAGVHSGDSA 236
+ +S L++K + E++ + + D +D ++ ME+I+ G+H+GDS
Sbjct: 189 KEIVENGLKLSPVHQCLLEKSIAGYKEIEYEVMRDSQDHAIVVCNMENIDPVGIHTGDSI 248
Query: 237 TSIPPYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNN--EVYVLEVNPRASRTVP 294
P +LS + ++ + KL AL ++G NVQ A+ + + Y++EVNPR SR+
Sbjct: 249 VVAPSQTLSDREYQLLRNVSLKLIRALGIEGGCNVQLALDPDSFQYYIIEVNPRVSRSSA 308
Query: 295 FVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVF 354
SK+ GYP+AK+A K+A+G SL E++ V G+ + A F P + S K +
Sbjct: 309 LASKATGYPIAKLAAKIAVGLSLDEMMNPV-----TGKTYAA--FEPALDYVVS-KIPRW 360
Query: 355 PWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKA 390
P+ +F + LG +MK+TGEVM I + + KA
Sbjct: 361 PFDKFESANRKLGTQMKATGEVMAIGRTLEESLLKA 396
sp|P46537|CARB_BACCL CARBAMOYL-PHOSPHATE SYNTHASE, PYRIMIDINE-SPECIFIC, LARGE CHAIN
(CARBAMOYL-PHOSPHATE SYNTHETASE AMMONIA CHAIN)
>gi|2118367|pir||I40169 carbamoyl-phosphate synthase
(glutamine-hydrolyzing) (EC 6.3.5.5) - Bacillus
caldolyticus >gi|312443|emb|CAA51739| (X73308)
carbamoyl-phosphate synthase (glutamine-hydrolysing)
[Bacillus caldolyticus]
Length = 1065
Score = 463 bits (1178), Expect = e-129
Identities = 237/513 (46%), Positives = 345/513 (67%), Gaps = 16/513 (3%)
Query: 5 VVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEPI 64
V++LGSGP RIGQGIEFDYA VH V+++++ GY A+++N NPETVSTD+ T+DKLYFEP+
Sbjct: 554 VIVLGSGPIRIGQGIEFDYATVHCVWAIKQAGYEAIIINNNPETVSTDFSTSDKLYFEPL 613
Query: 65 VFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFREL 124
E VM +I+ E+P GVI+QFGGQT + LA L+ GV++LGT E +D+AEDR+ F +
Sbjct: 614 TAEDVMHVIDLEQPIGVIVQFGGQTAINLAAELEARGVRLLGTTLEDLDRAEDRDKFEQA 673
Query: 125 IIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXXXA 184
+ ELG+ +P TA + EEA+ IA+EIG+PVLVRPSYVLGGRAM IVY+ A
Sbjct: 674 LSELGIPKPAGKTAVSVEEAVAIAEEIGYPVLVRPSYVLGGRAMEIVYNRGELLHYMEHA 733
Query: 185 VSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPYSL 244
V V+ + PVL+D+++ E++VDA++DG+ V+I +MEHIE AGVHSGDS PP +L
Sbjct: 734 VRVNPQHPVLVDRYITGK-EVEVDAIADGETVVIPGIMEHIERAGVHSGDSIAVYPPQTL 792
Query: 245 SKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGYPL 304
S E+++++ + T +LA L + GL+N+Q+ V ++VYVLEVNPR+SRTVPF+SK G P+
Sbjct: 793 SAEVIDKIADYTIRLARGLHIVGLLNIQFVVSGSDVYVLEVNPRSSRTVPFLSKITGVPM 852
Query: 305 AKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEVDP 364
A +ATK +G L E+ + + P ++ VK VF + + VD
Sbjct: 853 ANLATKAILGTKLAEM-------------GYETGVCPVRPGVY-VKVPVFSFAKLRNVDI 898
Query: 365 ILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILELAKEFE 424
LGPEMKSTGEV+G D F A YK +++G + G + ++VAD+DK + +ELA+ F
Sbjct: 899 SLGPEMKSTGEVIGKDVTFEKALYKGLVASGIHIQPHGAVLLTVADKDKEEAVELARRFA 958
Query: 425 KLGFGIYATSGTYKFLKEHGVNAKRVLKVSEGRPNVVDMIINGEIHLVINT-PSGKREKS 483
+G+ + AT+GT + LK G+ V K+ PN++D+I G+ +VINT GK+ +S
Sbjct: 959 DIGYQLLATNGTAETLKAAGIPVTVVNKIHSASPNILDVIRQGKAQVVINTLTKGKQPES 1018
Query: 484 DAYYIRRACVQFNVPYYTTMRAGYAVLEAIKSI 516
D + IRR V+ +P T++ A+L+ ++S+
Sbjct: 1019 DGFRIRREAVENGIPCLTSLDTARAMLQVLESM 1051
Score = 254 bits (643), Expect = 1e-66
Identities = 149/395 (37%), Positives = 228/395 (57%), Gaps = 17/395 (4%)
Query: 5 VVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEPI 64
++++GSGP IGQ EFDYA A +L+EEGY ++VN NP T+ TD + ADK+Y EP+
Sbjct: 10 ILVIGSGPIVIGQAAEFDYAGTQACLALKEEGYKVILVNSNPATIMTDTEIADKVYMEPL 69
Query: 65 VFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKN------GVKILGTKPESIDKAEDR 118
+ V II +E+P+ ++ GGQT L LA+ L K GV+ILGTK E+I+KAEDR
Sbjct: 70 TLDFVARIIRKERPDAILPTLGGQTGLNLAVELAKAGVLEECGVEILGTKLEAIEKAEDR 129
Query: 119 ELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXX 178
E FR L+ ELG P S + EEA ++IG+PV+VRP++ LGG I +
Sbjct: 130 EQFRALMNELGEPVPESAIIHSLEEAYAFVEQIGYPVIVRPAFTLGGTGGGICTNEEELV 189
Query: 179 XXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKD-VLIGAVMEHIEEAGVHSGDSAT 237
+ +S L+++ + E++ + + D D ++ ME+I+ G+H+GDS
Sbjct: 190 EIVSTGLKLSPVHQCLLERSIAGYKEIEYEVMRDANDNAIVVCNMENIDPVGIHTGDSIV 249
Query: 238 SIPPYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNN--EVYVLEVNPRASRTVPF 295
P +LS + ++ + K+ AL ++G NVQ A+ + YV+EVNPR SR+
Sbjct: 250 VAPSQTLSDREYQLLRNASLKIIRALGIEGGCNVQLALDPDSFRYYVIEVNPRVSRSSAL 309
Query: 296 VSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFP 355
SK+ GYP+AK+A K+A+G +L E++ V G+ + + F P + + K FP
Sbjct: 310 ASKATGYPIAKLAAKIAVGLTLDEMINPV-----TGKTY--ACFEPALDYVVT-KIPRFP 361
Query: 356 WKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKA 390
+ +F + LG +MK+TGEVM I + F + KA
Sbjct: 362 FDKFESANRRLGTQMKATGEVMAIGRTFEESLLKA 396
emb|CAA05020| (AJ001805) carbomylphosphate synthetase large subunit [Bacillus
stearothermophilus]
Length = 1064
Score = 456 bits (1160), Expect = e-127
Identities = 236/513 (46%), Positives = 344/513 (67%), Gaps = 17/513 (3%)
Query: 5 VVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEPI 64
V++LGSGP RIGQGIEFDYA VH V ++++ GY A+++N NPETVSTD+ T+DKLYFEP+
Sbjct: 554 VIVLGSGPIRIGQGIEFDYATVHCVLAIKQAGYEAIIINNNPETVSTDFSTSDKLYFEPL 613
Query: 65 VFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFREL 124
E VM +I+ E+P GVI+QFGGQT + LA L+ GV++LGT E +D+AEDR+ F +
Sbjct: 614 TAEDVMHVIDLEQPVGVIVQFGGQTAINLAAELEARGVRLLGTTLEDLDRAEDRDKFEQA 673
Query: 125 IIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXXXA 184
+ ELG+ +P TA + EEA+ IA+EIG+PVLVRPSYVLGGRAM IVY+ A
Sbjct: 674 LSELGIPKPAGKTAVSVEEAVAIAEEIGYPVLVRPSYVLGGRAMEIVYNREELLHYMEHA 733
Query: 185 VSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPYSL 244
V V+ + PVL+D+++ E++VDA++DG+ V+I +MEHIE AGVHSGDS PP +L
Sbjct: 734 VRVNPQHPVLVDRYITGK-EVEVDAIADGETVVIPGIMEHIERAGVHSGDSIAVYPPQTL 792
Query: 245 SKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGYPL 304
S +++ ++ + T KLA L + GL+N+Q+ V ++VYVLEVNPR+SRTVPF+SK G P+
Sbjct: 793 SDDVIAKITDYTVKLARGLHIVGLLNIQFVVAGSDVYVLEVNPRSSRTVPFLSKITGVPM 852
Query: 305 AKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEVDP 364
A +ATK +G L ++ + + P ++ VK VF + + VD
Sbjct: 853 ANLATKAILGAKLADM-------------GYETGVCPVRPGVY-VKVPVFSFAKLRNVDI 898
Query: 365 ILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILELAKEFE 424
LGPEMKSTGEV+G D F A YK +++G ++ G + ++VAD+DK + +ELA+ F
Sbjct: 899 SLGPEMKSTGEVIGKDVTFEKALYKGLVASGIQIQPHGAVLLTVADKDKEEAVELARRFA 958
Query: 425 KLGFGIYATSGTYKFLKEHGVNAKRVLKVSEGRPNVVDMIINGEIHLVINT-PSGKREKS 483
+G+ + AT+GT + LK G+ V K+ PN++D+I G+ +VINT GK+ +S
Sbjct: 959 DIGYQLLATNGTAETLKAAGIPVTVVNKIHSASPNILDVIRQGKAQVVINTLTKGKQPES 1018
Query: 484 DAYYIRRACVQFNVPYYTTMRAGYAVLEAIKSI 516
D + IRR V+ +P T++ A+L+ ++S+
Sbjct: 1019 DGFRIRRE-VENGIPCLTSLDTARAMLQVLESM 1050
Score = 253 bits (640), Expect = 2e-66
Identities = 148/395 (37%), Positives = 228/395 (57%), Gaps = 17/395 (4%)
Query: 5 VVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEPI 64
++++GSGP IGQ EFDYA A +L+EEGY ++VN NP T+ TD + ADK+Y EP+
Sbjct: 10 ILVIGSGPIVIGQAAEFDYAGTQACLALKEEGYKVILVNSNPATIMTDTEIADKVYMEPL 69
Query: 65 VFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKN------GVKILGTKPESIDKAEDR 118
+ V II +E+P+ ++ GGQT L LA+ L K GV+ILGTK E+I+KAEDR
Sbjct: 70 TLDFVARIIRKERPDAILPTLGGQTGLNLAVELAKAGVLEECGVEILGTKLEAIEKAEDR 129
Query: 119 ELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXX 178
E FR L+ ELG P S + EEA ++IG+PV+VRP++ LGG I +
Sbjct: 130 EQFRALMNELGEPVPESAIIHSLEEAYAFVEQIGYPVIVRPAFTLGGTGGGICTNEEELV 189
Query: 179 XXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKD-VLIGAVMEHIEEAGVHSGDSAT 237
+ +S L+++ + +++ + + D D ++ ME+I+ G+H+GDS
Sbjct: 190 EIVSTGLKLSPVHQCLLERSIAGYNQIEYEVMRDANDNAIVVCNMENIDPVGIHTGDSIV 249
Query: 238 SIPPYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNN--EVYVLEVNPRASRTVPF 295
P +LS + ++ + K+ AL ++G NVQ A+ + YV+EVNPR SR+
Sbjct: 250 VAPSQTLSDREYQLLRNASLKIIRALGIEGGCNVQLALDPDSFRYYVIEVNPRVSRSSAL 309
Query: 296 VSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFP 355
SK+ GYP+AK+A K+A+G +L E++ V G+ + + F P + + K FP
Sbjct: 310 ASKATGYPIAKLAAKIAVGLTLDEMINPV-----TGKTY--ACFEPALDYVVT-KIPRFP 361
Query: 356 WKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKA 390
+ +F + LG +MK+TGEVM I + F + KA
Sbjct: 362 FDKFESANRRLGTQMKATGEVMSIGRTFEESLLKA 396
sp|P77886|CARB_LACPL CARBAMOYL-PHOSPHATE SYNTHASE, PYRIMIDINE-SPECIFIC, LARGE CHAIN
(CARBAMOYL-PHOSPHATE SYNTHETASE AMMONIA CHAIN)
>gi|1514603|emb|CAA91005| (Z54240) carbamoyl-phosphate
synthase [Lactobacillus plantarum]
Length = 1058
Score = 446 bits (1136), Expect = e-124
Identities = 235/512 (45%), Positives = 328/512 (63%), Gaps = 16/512 (3%)
Query: 5 VVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEPI 64
V++LGSGP RIGQG+EFDYA VH+V ++Q+ GY A+++N NPETVSTD+ +DKLYFEP+
Sbjct: 554 VLVLGSGPIRIGQGVEFDYATVHSVKAIQKAGYEAIIMNSNPETVSTDFSVSDKLYFEPL 613
Query: 65 VFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFREL 124
E V+++IE EKP GVI+QFGGQT + LA PL +G+KILGT +++AEDR+ F ++
Sbjct: 614 TIEDVLNVIELEKPVGVIVQFGGQTAINLAKPLADHGIKILGTSVADVNRAEDRDEFDKV 673
Query: 125 IIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXXXA 184
I L + QP TA + AL IA ++G+PVLVRPSYVLGGRAM IV A
Sbjct: 674 IKALAIPQPAGDTASDEATALAIADKLGYPVLVRPSYVLGGRAMEIVKKRTDLDYYMHNA 733
Query: 185 VSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPYSL 244
V VSH+ PVL+D +L E +VDA+ DG+ VLI +MEHIE AGVHSGDS PP SL
Sbjct: 734 VKVSHDHPVLVDSYLVGK-ECEVDAICDGQTVLIPGIMEHIERAGVHSGDSMAVYPPQSL 792
Query: 245 SKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGYPL 304
S + ++ + T KLA+AL G++N+Q+ + +++VYV+EVNPRASRTVPF+SK P+
Sbjct: 793 SAAVQAQIVDYTEKLAIALNCVGMMNIQFVIHDDQVYVIEVNPRASRTVPFLSKVTNIPM 852
Query: 305 AKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEVDP 364
A++AT+ +G+SL E + + G L + VK VF + + VD
Sbjct: 853 AQVATRAILGQSLAE------QGYQTG--------LVTPGPLVHVKAPVFSFSKLNRVDS 898
Query: 365 ILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILELAKEFE 424
+LGPEMKSTGEVMG D A YKA +A +P GN+ ++V D DKP+ + LAK F
Sbjct: 899 LLGPEMKSTGEVMGSDVTMAKALYKAFEAAKLHVPSHGNVLLTVRDEDKPETVALAKRFH 958
Query: 425 KLGFGIYATSGTYKFLKEHGVNAKRVLKVSEGRPNVVDMIINGEIHLVINTPSGKRE-KS 483
LG+ + AT GT L HG+ V K+ G +++ + GE+ +VINT S + + ++
Sbjct: 959 ALGYQLLATRGTATALTTHGLPVTTVDKIDSGEHDLLHRMEAGEVQVVINTVSDEEQAEN 1018
Query: 484 DAYYIRRACVQFNVPYYTTMRAGYAVLEAIKS 515
D IR + +P +T + A+L+ +S
Sbjct: 1019 DGTLIRNTSIMHGIPLFTALDTVAAILQVRES 1050
Score = 251 bits (635), Expect = 9e-66
Identities = 147/396 (37%), Positives = 227/396 (57%), Gaps = 17/396 (4%)
Query: 4 KVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEP 63
K++++GSGP IGQ EFDY+ A +L+E Y V+VN NP T+ TD + AD++Y EP
Sbjct: 9 KIMVIGSGPIIIGQAAEFDYSGTQACLALKELDYEVVLVNSNPATIMTDKEIADQVYLEP 68
Query: 64 IVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNG------VKILGTKPESIDKAED 117
I E V I+ +E P+ ++ GGQ L +A+ L K+G +++LGTK +ID+AED
Sbjct: 69 ITLEFVSQILRKEHPDAILPTLGGQQGLNMAMELSKSGILDELHIELLGTKLSAIDQAED 128
Query: 118 RELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXX 177
RE F+ L+ ELG P SG ART +EAL A++ G+PV+VRP++ +GG I
Sbjct: 129 REQFKALMEELGEPVPASGIARTVDEALAFAEQAGYPVIVRPAFTMGGTGGGIAETPQQL 188
Query: 178 XXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKD-VLIGAVMEHIEEAGVHSGDSA 236
+++S VLI++ + E++ + + D D ++ ME+ + G+H+GDS
Sbjct: 189 HDITENGLALSPVTQVLIEQSIAGYKEIEFEVMRDAADNAMVVCNMENFDPVGIHTGDSI 248
Query: 237 TSIPPYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNN--EVYVLEVNPRASRTVP 294
P +L+ V+ +++ K+ AL+++G NVQ A+ N Y++EVNPR SR+
Sbjct: 249 VYAPVQTLADREVQLLRDAALKIIRALKIEGGCNVQLALDPNSFNYYIIEVNPRVSRSSA 308
Query: 295 FVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVF 354
SK+ GYP+AK+A K+A+G L EI V G + ++F P + K +
Sbjct: 309 LASKATGYPIAKMAAKIAVGLHLDEIKNPV-----TGTTY--AEFEPALDYVV-CKIPRW 360
Query: 355 PWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKA 390
P+ +F D LG +MK+TGEVM I + A KA
Sbjct: 361 PFDKFTHADRRLGTQMKATGEVMAIGRNIEEATLKA 396
emb|CAA72256| (Y11467) carbamoyl-phosphate synthase (glutamine-hydrolysing) large
subunit [Thermus thermophilus]
Length = 1028
Score = 441 bits (1121), Expect = e-123
Identities = 224/402 (55%), Positives = 291/402 (71%), Gaps = 16/402 (3%)
Query: 4 KVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEP 63
KVVILGSGP RIGQG+EFDY VHAV++L+E G+ +MVN NPETVSTDYDTAD+LY EP
Sbjct: 556 KVVILGSGPIRIGQGVEFDYPTVHAVWALKEAGFETIMVNSNPETVSTDYDTADRLYVEP 615
Query: 64 IVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFRE 123
+ E V++I+E +KP GVI GGQTPLKLA L++ GV++LGT +I +AEDRE F
Sbjct: 616 LTLEDVLNIVEHQKPIGVIATLGGQTPLKLAKGLEEAGVRLLGTPFSAIHQAEDREAFHA 675
Query: 124 LIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXXX 183
L LG+ QP A++ EEAL++A E+GFP+LVRPSYVLGGRAM++V D
Sbjct: 676 LCQRLGIPQPEGRVAQSPEEALRLAPEVGFPLLVRPSYVLGGRAMQVVRDEGELKRYLEE 735
Query: 184 AVSVSHERP-VLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPY 242
+ ERP +L+D+FL+ +IELDVDA+SDG++V++ +MEH+E AGVHSGDSAT +PP
Sbjct: 736 VYAPLEERPSILLDRFLEGAIELDVDALSDGQEVMVAGIMEHVERAGVHSGDSATLLPPV 795
Query: 243 SLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGY 302
+ +E +++V++ TR+LA+ L V+GL+NVQYAV EVYVLE NPRASRTVPFVSK+IG
Sbjct: 796 HVPEEALKKVRDYTRRLALTLGVRGLLNVQYAVVGEEVYVLEANPRASRTVPFVSKAIGV 855
Query: 303 PLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEV 362
PLAK+A +A+GK+L+E+ L ++ KEVV PW +FP V
Sbjct: 856 PLAKLAALIAVGKTLKEL---------------GVRDLDPVPPYYAAKEVVIPWIKFPGV 900
Query: 363 DPILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNL 404
P LGPEM+STGE MGID++ LAYYKA+L AG RLP G +
Sbjct: 901 IPELGPEMRSTGESMGIDQDPYLAYYKAELGAGQRLPLSGQV 942
Score = 228 bits (574), Expect = 1e-58
Identities = 141/398 (35%), Positives = 219/398 (54%), Gaps = 11/398 (2%)
Query: 3 KKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFE 62
KK++I+GSGP IGQ EFDY+ AV +L+ GY V+VN NP T+ TD + A++ Y E
Sbjct: 8 KKILIIGSGPITIGQAAEFDYSGTQAVKALRGAGYRVVLVNSNPATIMTDPELAERTYIE 67
Query: 63 PIVFEHVMDIIEREKPEGVILQFGGQTPLKLALP------LQKNGVKILGTKPESIDKAE 116
P+ EH+ I+ RE P+ ++ GGQT L LA+ LQK GV+++G K E+I K E
Sbjct: 68 PLDLEHLEGILAREAPDALLPTLGGQTGLNLAMALYEEGILQKYGVELIGAKAEAIRKGE 127
Query: 117 DRELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXX 176
DRE F+E + + L+ P + EE L A+E+GFPV+VRPS+ LGG I +D
Sbjct: 128 DREAFQEAMRRIDLEVPRGQLVGSVEEGLHFAREVGFPVVVRPSFTLGGTGGGIAHDEAE 187
Query: 177 XXXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKD-VLIGAVMEHIEEAGVHSGDS 235
+++S L+++ + E +++ + D D V+I +E+++ GVH+GDS
Sbjct: 188 LVEVLSRGLTLSPVHTALVEESVLGWKEFELEVMRDHADTVVIITSIENVDPMGVHTGDS 247
Query: 236 ATSIPPYSLSKEIVEEVKEQTRKLAVALEVK-GLINVQYAV--QNNEVYVLEVNPRASRT 292
T P +LS + +++ + + + V+ G N+Q+AV + V+E+NPR SR+
Sbjct: 248 ITVAPAQTLSDVEYQRMRDAAKAIIREIGVETGGSNIQFAVDPKTGRQVVIEMNPRVSRS 307
Query: 293 VPFVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEV 352
SK+ G+P+AKIA +A+ L E LP R D++ + F+ ++
Sbjct: 308 SALASKATGFPIAKIAALLAVPYRLDE-LPNDITRKTPASFEPTIDYVVVKIPRFAFEKF 366
Query: 353 VFPWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKA 390
E+ L +MKS GEVM I + F A KA
Sbjct: 367 RPLRNTLGELKDELTTQMKSVGEVMAIGRTFKEALMKA 404
emb|CAA03928| (AJ000109) carbamoylphosphate synthetase [Lactococcus lactis]
Length = 1064
Score = 439 bits (1116), Expect = e-122
Identities = 228/520 (43%), Positives = 338/520 (64%), Gaps = 22/520 (4%)
Query: 3 KKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFE 62
+K+++LGSGP RIGQG+EFDYA VH V ++Q G A+++N NPETVSTD+ +DKLYFE
Sbjct: 552 EKIIVLGSGPIRIGQGVEFDYATVHCVKAIQALGKEAIVINSNPETVSTDFSISDKLYFE 611
Query: 63 PIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFR 122
P+ FE VM++I+ E+P VI+QFGGQT + LA L K GVKILGT+ E +D+AEDR+LF
Sbjct: 612 PLTFEDVMNVIDLEEPLVVIVQFGGQTAINLAEHLSKAGVKILGTQVEDLDRAEDRDLFE 671
Query: 123 ELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXX 182
+ + +L + QPP TA +EEA+ A +IG+PVL+RPS+VLGGRAM I+ +
Sbjct: 672 KALQDLDIPQPPGATATNEEEAVANANKIGYPVLIRPSFVLGGRAMEIINNEKDLRDYMN 731
Query: 183 XAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPY 242
AV S E PVL+D +L E +VDA+ DGK+VL+ +MEHIE AGVHSGDS PP
Sbjct: 732 RAVKASPEHPVLVDSYLQGQ-ECEVDAICDGKEVLLPGIMEHIERAGVHSGDSMAVYPPQ 790
Query: 243 SLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGY 302
+LS+ I++ + + T++LA+ L G++N+Q+ + +VYV+EVNPRASRTVPF+SK
Sbjct: 791 NLSQAIIDTIVDYTKRLAIGLNCIGMMNIQFVIYEEQVYVIEVNPRASRTVPFLSKVTNI 850
Query: 303 PLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEV 362
P+A++AT++ +G++L+++ E G L + VK VF + + +V
Sbjct: 851 PMAQLATQMILGENLKDL------GYEAG--------LAPTPDMVHVKAPVFSFTKLAKV 896
Query: 363 DPILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILELAKE 422
D +LGPEMKSTG MG D A YK+ +A + + G++ +VAD DK + L LAK+
Sbjct: 897 DSLLGPEMKSTGLAMGSDVTLEKALYKSFEAAKLHMADYGSVLFTVADEDKEETLALAKD 956
Query: 423 FEKLGFGIYATSGTYKFLKEHGVNAKRVLKVSEGRP---NVVDMIINGEIHLVINTPSGK 479
F ++G+ + AT+GT FLKE+G+ + V K++ G +V+ I G + V+NT
Sbjct: 957 FAEIGYSLVATAGTAAFLKENGLYVREVEKLAGGEDEEGTLVEDIRQGRVQAVVNTMGNT 1016
Query: 480 REK----SDAYYIRRACVQFNVPYYTTMRAGYAVLEAIKS 515
R +D + IR+ + +P +T++ A+L+ ++S
Sbjct: 1017 RASLTTATDGFRIRQEAISRGIPLFTSLDTVAAILKVMQS 1056
Score = 250 bits (632), Expect = 2e-65
Identities = 152/399 (38%), Positives = 225/399 (56%), Gaps = 21/399 (5%)
Query: 3 KKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFE 62
KK++I+GSGP IGQ EFDYA A +L+EEGY V+VN NP T+ TD + AD +Y E
Sbjct: 8 KKIMIIGSGPIIIGQAAEFDYAGTEACLALKEEGYEVVLVNSNPATIMTDREIADTVYIE 67
Query: 63 PIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNG------VKILGTKPESIDKAE 116
PI E V I+ +E+P+ ++ GGQT L +A+ L K G V++LGTK +ID+AE
Sbjct: 68 PITLEFVSKILRKERPDALLPTLGGQTGLNMAMELSKTGILEELNVELLGTKLSAIDQAE 127
Query: 117 DRELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXX 176
DRELF+EL + S A T EEA+ IA +IG+P++V P++ +GG I
Sbjct: 128 DRELFKELCESINEPLCASDIATTVEEAINIADKIGYPIIVGPAFTMGGTGGGICDTEEE 187
Query: 177 XXXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKD-VLIGAVMEHIEEAGVHSGDS 235
+ +S LI++ + E++ + + D D ++ ME+ + GVH+GDS
Sbjct: 188 LREIVANGLKLSPVTQCLIEESIAGYKEIEYEVMRDSADNAIVVCNMENFDPVGVHTGDS 247
Query: 236 ATSIPPYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNN--EVYVLEVNPRASRTV 293
P +LS + +++ + + AL+++G NVQ A+ N E V+EVNPR SR+
Sbjct: 248 IVFAPSQTLSDNEYQMLRDASLNIIRALKIEGGCNVQLALDPNSYEYRVIEVNPRVSRSS 307
Query: 294 PFVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHF--ASDFLPKEKKIFSVKE 351
SK+ GYP+AK++ K+AIG +L EI+ V K A F A D++ K
Sbjct: 308 ALASKATGYPIAKMSAKIAIGMTLDEIINPV---TNKTYAMFEPALDYV-------VAKI 357
Query: 352 VVFPWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKA 390
FP+ +F D LG +MK+TGEVM I + + KA
Sbjct: 358 ARFPFDKFENGDRHLGTQMKATGEVMAIGRNIEESLLKA 396
gb|AAF10248.1|AE001924_1 (AE001924) carbamoyl-phosphate synthase, large subunit [Deinococcus
radiodurans]
Length = 1024
Score = 416 bits (1059), Expect = e-115
Identities = 215/404 (53%), Positives = 280/404 (69%), Gaps = 17/404 (4%)
Query: 4 KVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEP 63
KVVILGSGPNRIGQG+EFDYA VHAV++LQE GY +MVN NPETVSTDYDTAD+LYFEP
Sbjct: 553 KVVILGSGPNRIGQGVEFDYATVHAVWALQEAGYETIMVNSNPETVSTDYDTADRLYFEP 612
Query: 64 IVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFRE 123
+ FE VM+I+E EKP GVI+Q GGQTPLKLA L G I+GT PE+I +AEDR F
Sbjct: 613 LTFEDVMNIVEHEKPVGVIVQLGGQTPLKLAKKLADAGAPIIGTSPETIHEAEDRASFNA 672
Query: 124 LIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXXX 183
L LGL QP A+T +A ++A E+GFP++ RPSYVLGGRAMR V
Sbjct: 673 LCERLGLPQPRGKVAQTPAQARELAAELGFPLMARPSYVLGGRAMRTVRSMDELTTYLDE 732
Query: 184 AVSVSHERP-VLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPY 242
+ +P +L+D+FL+ ++ELDVD + DG+ ++ +MEH+E AGVHSGDSA +PP
Sbjct: 733 VYAAVEGQPSILLDQFLEGALELDVDTLCDGERAVVAGIMEHVEAAGVHSGDSACILPPV 792
Query: 243 SLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGY 302
+L ++E VK T +LA+ L V+GL+NVQ+AV++ Y+LE NPRASRTVPFVSK++ +
Sbjct: 793 TLDAGVLERVKADTERLALELGVRGLMNVQWAVKDGTAYILEANPRASRTVPFVSKAVNH 852
Query: 303 PLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEV 362
PLAK A ++A G++L +I LE +++SVKEV P+ +F +V
Sbjct: 853 PLAKSAARIAAGQTLEQI-----GLLE-----------TPTPRMYSVKEVHLPFLKFKDV 896
Query: 363 DPILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFI 406
P+LGPEMKSTGE MGID + LA+Y+AQL A LP +G +
Sbjct: 897 LPVLGPEMKSTGESMGIDSDPYLAFYRAQLGAKNYLPLEGTALL 940
Score = 233 bits (588), Expect = 3e-60
Identities = 144/398 (36%), Positives = 223/398 (55%), Gaps = 22/398 (5%)
Query: 5 VVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEPI 64
++ILGSGP +IGQ EFDY+ A+ +L+ EGY ++VN NP T+ TD + AD Y EP+
Sbjct: 10 ILILGSGPIQIGQAAEFDYSGTQALKALKNEGYRVILVNSNPATIMTDPELADATYLEPL 69
Query: 65 VFEHVMDIIEREKPEGVILQFGGQTPLKLAL------PLQKNGVKILGTKPESIDKAEDR 118
E V IIE+EKP+ ++ GGQT L LA+ L+K GV+++G E+I K EDR
Sbjct: 70 TPEFVEKIIEKEKPDAILPTLGGQTALNLAMELHERGSLEKYGVELIGAGVEAIKKGEDR 129
Query: 119 ELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXX 178
ELF+ + ++G++ + EEA++ KEIG P+++RPS+ LGG I +
Sbjct: 130 ELFQAAMKKIGVETARGKMVHSMEEAVEYQKEIGLPIVIRPSFTLGGTGGGIAHTYEEFL 189
Query: 179 XXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKD-VLIGAVMEHIEEAGVHSGDSAT 237
+ S VL+++ + E +++ + D D V+I +E+ + GVH+GDS T
Sbjct: 190 AITEGGLRDSPVTSVLLEESILGWKEYELEVMRDTADTVIIITSIENFDPMGVHTGDSIT 249
Query: 238 SIPPYSLSKEIVEEVKEQTRKLAVALEV---KGLINVQYAV--QNNEVYVLEVNPRASRT 292
P +LS + +++Q+ LA+ E+ G N+Q+AV N V V+E+NPR SR+
Sbjct: 250 VAPAQTLSDVEYQRLRDQS--LAIIREIGVATGGSNIQFAVNPDNGRVIVIEMNPRVSRS 307
Query: 293 VPFVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEV 352
SK+ G+P+AKIA +A+G L E LP R+ + D++ K
Sbjct: 308 SALASKATGFPIAKIAALLAVGYHLDE-LPNDITRVTPASFEPSIDYV-------VTKIP 359
Query: 353 VFPWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKA 390
F +++FP LG +M+S GEVM I + F + KA
Sbjct: 360 RFAFEKFPGTPDGLGTQMRSVGEVMAIGRTFKESLQKA 397
sp|P13258|CARB_METBA CARBAMOYL-PHOSPHATE SYNTHASE LARGE CHAIN (CARBAMOYL-PHOSPHATE
SYNTHETASE AMMONIA CHAIN) >gi|149817 (M21314) carbamyl
phosphate synthetase [Methanosarcina barkeri]
Length = 398
Score = 415 bits (1055), Expect = e-115
Identities = 214/411 (52%), Positives = 288/411 (70%), Gaps = 24/411 (5%)
Query: 127 ELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXXXAVS 186
+LG+ QP G A +++EA+++AK IGFPVLVRPSYVLGGRAM IVYD AV
Sbjct: 1 KLGVPQPEGGYATSQKEAIEVAKRIGFPVLVRPSYVLGGRAMEIVYDEMDLERYMKEAVR 60
Query: 187 VSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPYSLSK 246
VSHE P+LID FL+ + E+DVDAV D KDV+IGA+MEHIEEAGVHSGDSA IPP SLS
Sbjct: 61 VSHEHPILIDDFLEAASEIDVDAVCDQKDVIIGAIMEHIEEAGVHSGDSACVIPPQSLSP 120
Query: 247 EIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGYPLAK 306
E++++V++ TRK+A+AL VKGLIN+Q A + +VYVLE NPR+SRT+PFVSK++G PLAK
Sbjct: 121 EVLDQVRDYTRKIALALRVKGLINIQMAEKGGKVYVLEANPRSSRTIPFVSKAVGIPLAK 180
Query: 307 IATKVAIGKSLREI--LPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEVDP 364
IA KV +G SL+ + + E PK K + S+KEV+ P+ + P DP
Sbjct: 181 IAAKVIVGHSLKSLGYMDE-----------------PKPKHV-SIKEVLLPFDKLPGADP 222
Query: 365 ILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILELAKEFE 424
+LGPEMKSTGEVMGID +FG AYYKA+L+A LP G +F+S+ + DK +++++AK+ +
Sbjct: 223 VLGPEMKSTGEVMGIDYDFGRAYYKAELAADNVLPLTGKVFLSIRNADKTELVDVAKKLQ 282
Query: 425 KLGFGIYATSGTYKFLKEHGVNAKRVLKVSEGRPNVVDMIINGEIHLVINTPSGKREKSD 484
G + T GT +L +HGV V KV +G PNV+DM+ E++L+INTP+ K+ + D
Sbjct: 283 AAGLELMGTEGTVNYLAQHGVFMDVVKKVHDGSPNVIDMMRRDEVNLIINTPTSKQSRRD 342
Query: 485 AYYIRRACVQFNVPYYTTMRAGYAVLEAIKSIKKLKEEGKGLSVHSLQEIY 535
IRRA V F VPY TTM+A A AI+++KK G+ L++ S+ E +
Sbjct: 343 GSRIRRAAVDFKVPYITTMQAAIAAAAAIETMKK----GEELTIKSINEYH 389
pir||A28180 carbamoyl-phosphate synthase (glutamine-hydrolyzing) (EC 6.3.5.5)
large chain - Methanosarcina barkeri (strain MS)
(fragment)
Length = 397
Score = 410 bits (1042), Expect = e-113
Identities = 214/411 (52%), Positives = 287/411 (69%), Gaps = 25/411 (6%)
Query: 127 ELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXXXAVS 186
+LG+ QP G A +++EA+++AK IGFPVLVRPSYVLGGRAM IVYD AV
Sbjct: 1 KLGVPQPEGGYATSQKEAIEVAKRIGFPVLVRPSYVLGGRAMEIVYDEMDLERYMKEAVR 60
Query: 187 VSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPYSLSK 246
VSHE P+LID FL+ + E+DVDAV D KDV+IGA+MEHIEEAGVHSGDSA IPP SLS
Sbjct: 61 VSHEHPILIDDFLEAASEIDVDAVCDQKDVIIGAIMEHIEEAGVHSGDSACVIPPQSLSP 120
Query: 247 EIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGYPLAK 306
E++++V++ TRK+A+AL VKGLIN+Q A + +VYVLE NPR SRT+PFVSK++G PLAK
Sbjct: 121 EVLDQVRDYTRKIALALRVKGLINIQMAEKGGKVYVLEANPR-SRTIPFVSKAVGIPLAK 179
Query: 307 IATKVAIGKSLREI--LPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEVDP 364
IA KV +G SL+ + + E PK K + S+KEV+ P+ + P DP
Sbjct: 180 IAAKVIVGHSLKSLGYMDE-----------------PKPKHV-SIKEVLLPFDKLPGADP 221
Query: 365 ILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILELAKEFE 424
+LGPEMKSTGEVMGID +FG AYYKA+L+A LP G +F+S+ + DK +++++AK+ +
Sbjct: 222 VLGPEMKSTGEVMGIDYDFGRAYYKAELAADNVLPLTGKVFLSIRNADKTELVDVAKKLQ 281
Query: 425 KLGFGIYATSGTYKFLKEHGVNAKRVLKVSEGRPNVVDMIINGEIHLVINTPSGKREKSD 484
G + T GT +L +HGV V KV +G PNV+DM+ E++L+INTP+ K+ + D
Sbjct: 282 AAGLELMGTEGTVNYLAQHGVFMDVVKKVHDGSPNVIDMMRRDEVNLIINTPTSKQSRRD 341
Query: 485 AYYIRRACVQFNVPYYTTMRAGYAVLEAIKSIKKLKEEGKGLSVHSLQEIY 535
IRRA V F VPY TTM+A A AI+++KK G+ L++ S+ E +
Sbjct: 342 GSRIRRAAVDFKVPYITTMQAAIAAAAAIETMKK----GEELTIKSINEYH 388
pir||A49930 carB protein homolog - Mycobacterium bovis (strain BCG) (fragment)
Length = 496
Score = 400 bits (1017), Expect = e-110
Identities = 217/444 (48%), Positives = 289/444 (64%), Gaps = 23/444 (5%)
Query: 4 KVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPET-VSTDYDTADKLYFE 62
KV+ILGSGPNRIGQGIEFDY+CVHA +L + G+ VMVNCNPET VSTD+DTAD+LYFE
Sbjct: 18 KVLILGSGPNRIGQGIEFDYSCVHAATTLSQAGFETVMVNCNPETMVSTDFDTADRLYFE 77
Query: 63 PIVFEHVMDIIEREKPEG--------VILQFGGQTPLKLALPLQKNGVKILGTKPESIDK 114
P+ FE V+++ E G VI+Q GGQTPL G G PE+ID
Sbjct: 78 PLTFEDVLEVYHAEMESGSGGPGVAGVIVQLGGQTPLGWRTGSPTPG-PARGHPPEAIDL 136
Query: 115 AEDRELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDX 174
AED + R E GL P GTA T +A +IA+EIG+PVLVRPSYVLGGR M IVYD
Sbjct: 137 AEDAAVRRPA--ERGLPAPKYGTATTFAQARRIAEEIGYPVLVRPSYVLGGRGMEIVYDE 194
Query: 175 XXXXXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGD 234
A +S E PVL+ +FL++++E+DVDA+ DG +V IG +MEHIEEAG+HSGD
Sbjct: 195 ETLQGYITRATQLSPEHPVLVHRFLEDAVEIDVDALCDGAEVYIGGIMEHIEEAGIHSGD 254
Query: 235 SATSIPPYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVP 294
SA ++PP +L + +E+V++ T +A + V GL+NVQ A++++ +YVLE NPRASRTVP
Sbjct: 255 SACALPPVTLGRSDIEKVRKATEAIAHGIGVVGLLNVQSALKDDVLYVLEANPRASRTVP 314
Query: 295 FVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVF 354
FVSK+ PLAK ++ +G ++ ++ E + AH A +V + V
Sbjct: 315 FVSKATAVPLAKACARIMLGATIAQLRAEGLLAVTGDGAHAA------RNAPIAVNQAVL 368
Query: 355 PWKRF-----PEVDPILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVA 409
P+ RF +D +LGPEMKSTGEVMGID++FG + K+Q +A LP +G +F+SVA
Sbjct: 369 PFHRFRRADGAAIDSLLGPEMKSTGEVMGIDRDFGSRFAKSQTAAYGSLPAQGTVFVSVA 428
Query: 410 DRDKPKILELAKEFEKLGFGIYAT 433
+RDK ++ K LGF + AT
Sbjct: 429 NRDKRSLVFPVKRLAHLGFRVLAT 452
pir||S53602 carbamoyl-phosphate synthase (glutamine-hydrolyzing) (EC 6.3.5.5) III
precursor, hepatic - spiny dogfish
Length = 1502
Score = 374 bits (950), Expect = e-102
Identities = 213/522 (40%), Positives = 303/522 (57%), Gaps = 21/522 (4%)
Query: 5 VVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEPI 64
+++LG GP IG +EFD+ V ++ +L++ G V+VN NPETVSTD+D D+LYFE +
Sbjct: 977 IMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVVNHNPETVSTDFDECDRLYFEEL 1036
Query: 65 VFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFREL 124
E ++DI E+E +G I+ GGQ P LA+PL K GV ILGT P ID+AEDR +F +
Sbjct: 1037 SLERILDIYEQEGCKGSIISVGGQIPNNLAVPLYKYGVNILGTNPMQIDRAEDRAVFSAV 1096
Query: 125 IIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXXXA 184
+ EL + Q P T ++AL A+ +G+P L+RPSYVL G AM + +D A
Sbjct: 1097 LDELQVSQAPWTAVNTLDDALSFAETVGYPCLLRPSYVLSGSAMNVAHDAVEMKKFLAEA 1156
Query: 185 VSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPYSL 244
VS E PV+I KF++ + E++VDAVS VL A+ EH+E+AGVHSGD+ +P ++
Sbjct: 1157 ARVSQEHPVVITKFIEGAREVEVDAVSKDGKVLAHAITEHVEDAGVHSGDATLILPTQTI 1216
Query: 245 SKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGYPL 304
S+ +E+VK TRK++ A E+ G NVQ+ V+ N+V V+E N RASR+ PFVSK+IG L
Sbjct: 1217 SQGALEKVKIATRKISEAFEISGPFNVQFLVKGNDVMVIECNLRASRSCPFVSKTIGVDL 1276
Query: 305 AKIATKVAIGKSLRE-ILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEVD 363
+AT+V G+S+ E LP + + +P E +K +F W R + D
Sbjct: 1277 INVATRVMTGESIDESSLPSL-----------ENPIIPTE--YVGIKAPMFSWPRLRDAD 1323
Query: 364 PILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILELAKEF 423
PIL EM STGEV A+ KA LS G+RLP+KG + I + + K L+ A++
Sbjct: 1324 PILRCEMASTGEVACFGPNIYSAFLKAILSTGFRLPQKG-ILIGIQSSFRSKFLDTAQQL 1382
Query: 424 EKLGFGIYATSGTYKFLKEHGVNAKRVL-----KVSEGRPNVVDMIINGEIHLVINTPSG 478
+ G+ +YAT GT +L + V V S P+ +I +G I LVIN P+
Sbjct: 1383 HEQGYKLYATEGTSTWLNVNDVPTAPVSWPTAEDHSSSAPSFTKLIHDGVIDLVINLPNN 1442
Query: 479 K-REKSDAYYIRRACVQFNVPYYTTMRAGYAVLEAIKSIKKL 519
R + Y IRR + VP T + +EAIK KL
Sbjct: 1443 NTRFMRENYLIRRMAIDHGVPLITNFQVAKLFVEAIKHCGKL 1484
Score = 208 bits (523), Expect = 1e-52
Identities = 139/399 (34%), Positives = 214/399 (52%), Gaps = 22/399 (5%)
Query: 4 KVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDY---DTADKLY 60
KV++LGSG IGQ EFDY+ A+ +L+EE V++N N +V T+ AD +Y
Sbjct: 425 KVLVLGSGGLSIGQAGEFDYSGSQAIKALKEENLKTVLMNPNIASVQTNEVGTKQADTVY 484
Query: 61 FEPIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPL------QKNGVKILGTKPESIDK 114
F P+ E V DII+ EKP+G++L GGQT L + L +K GV++LGT S+
Sbjct: 485 FLPVTPEFVTDIIKTEKPDGILLSMGGQTALNCGVALYKQGVLEKYGVQVLGTPITSVMA 544
Query: 115 AEDRELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDX 174
EDR+LF + ++E+ K PS T E+A + A++IG+PV+VR +Y LGG + +
Sbjct: 545 TEDRQLFADKLLEINEKIAPSFAVETLEDAFQAAEKIGYPVMVRAAYALGGLGSGLCNNK 604
Query: 175 XXXXXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAV-MEHIEEAGVHSG 233
A++++ + +L+++ L E++ + V D D + ME+ + G+H+G
Sbjct: 605 EKLNEIAGNALAMTTQ--ILVEQSLLGWKEVEYEVVRDAADNCVTVCNMENFDPLGIHTG 662
Query: 234 DSATSIPPYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQ--NNEVYVLEVNPRASR 291
DS P +LS E ++E K+ LE+ G N+QYA+ + E ++EVN R SR
Sbjct: 663 DSVVVAPSQTLSNEEYHMLRETAIKVVRHLEIVGECNIQYALHPLSLEYCIIEVNARLSR 722
Query: 292 TVPFVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKE 351
+ SK+ GYPLA +A K+A+G L +I V + F P I + K
Sbjct: 723 SSALASKATGYPLAFVAAKLALGIPLPDIKNAV-------SGKTTACFEPSLDYIVT-KI 774
Query: 352 VVFPWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKA 390
+ RF +G MKS GEVM I + F ++ KA
Sbjct: 775 PRWDLDRFHGASREIGSSMKSVGEVMAIGRTFEESFQKA 813
gi|530209 (L31362) carbamyl phosphate synthetase III [Squalus acanthias]
Length = 1502
Score = 374 bits (950), Expect = e-102
Identities = 213/522 (40%), Positives = 303/522 (57%), Gaps = 21/522 (4%)
Query: 5 VVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEPI 64
+++LG GP IG +EFD+ V ++ +L++ G V+VN NPETVSTD+D D+LYFE +
Sbjct: 977 IMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVVNHNPETVSTDFDECDRLYFEEL 1036
Query: 65 VFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFREL 124
E ++DI E+E +G I+ GGQ P LA+PL K GV ILGT P ID+AEDR +F +
Sbjct: 1037 SLERILDIYEQEGCKGSIISVGGQIPNNLAVPLYKYGVNILGTNPMQIDRAEDRAVFSAV 1096
Query: 125 IIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXXXA 184
+ EL + Q P T ++AL A+ +G+P L+RPSYVL G AM + +D A
Sbjct: 1097 LDELQVSQAPWTAVNTLDDALSFAETVGYPCLLRPSYVLSGSAMNVAHDAVEMKKFLAEA 1156
Query: 185 VSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPYSL 244
VS E PV+I KF++ + E++VDAVS VL A+ EH+E+AGVHSGD+ +P ++
Sbjct: 1157 ARVSQEHPVVITKFIEGAREVEVDAVSKDGKVLAHAITEHVEDAGVHSGDATLILPTQTI 1216
Query: 245 SKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGYPL 304
S+ +E+VK TRK++ A E+ G NVQ+ V+ N+V V+E N RASR+ PFVSK+IG L
Sbjct: 1217 SQGALEKVKIATRKISEAFEISGPFNVQFLVKGNDVMVIECNLRASRSCPFVSKTIGVDL 1276
Query: 305 AKIATKVAIGKSLRE-ILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEVD 363
+AT+V G+S+ E LP + + +P E +K +F W R + D
Sbjct: 1277 INVATRVMTGESIDESSLPSL-----------ENPIIPTE--YVGIKAPMFSWPRLRDAD 1323
Query: 364 PILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILELAKEF 423
PIL EM STGEV A+ KA LS G+RLP+KG + I + + K L+ A++
Sbjct: 1324 PILRCEMASTGEVACFGPNIYSAFLKAILSTGFRLPQKG-ILIGIQSSFRSKFLDTAQQL 1382
Query: 424 EKLGFGIYATSGTYKFLKEHGVNAKRVL-----KVSEGRPNVVDMIINGEIHLVINTPSG 478
+ G+ +YAT GT +L + V V S P+ +I +G I LVIN P+
Sbjct: 1383 HEQGYKLYATEGTSTWLNVNDVPTAPVSWPTAEDHSSSAPSFTKLIHDGVIDLVINLPNN 1442
Query: 479 K-REKSDAYYIRRACVQFNVPYYTTMRAGYAVLEAIKSIKKL 519
R + Y IRR + VP T + +EAIK KL
Sbjct: 1443 NTRFMRENYLIRRMAIDHGVPLITNFQVAKLFVEAIKHCGKL 1484
Score = 208 bits (523), Expect = 1e-52
Identities = 139/399 (34%), Positives = 214/399 (52%), Gaps = 22/399 (5%)
Query: 4 KVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDY---DTADKLY 60
KV++LGSG IGQ EFDY+ A+ +L+EE V++N N +V T+ AD +Y
Sbjct: 425 KVLVLGSGGLSIGQAGEFDYSGSQAIKALKEENLKTVLMNPNIASVQTNEVGTKQADTVY 484
Query: 61 FEPIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPL------QKNGVKILGTKPESIDK 114
F P+ E V DII+ EKP+G++L GGQT L + L +K GV++LGT S+
Sbjct: 485 FLPVTPEFVTDIIKTEKPDGILLSMGGQTALNCGVALYKQGVLEKYGVQVLGTPITSVMA 544
Query: 115 AEDRELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDX 174
EDR+LF + ++E+ K PS T E+A + A++IG+PV+VR +Y LGG + +
Sbjct: 545 TEDRQLFADKLLEINEKIAPSFAVETLEDAFQAAEKIGYPVMVRAAYALGGLGSGLCNNK 604
Query: 175 XXXXXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAV-MEHIEEAGVHSG 233
A++++ + +L+++ L E++ + V D D + ME+ + G+H+G
Sbjct: 605 EKLNEIAGNALAMTTQ--ILVEQSLLGWKEVEYEVVRDAADNCVTVCNMENFDPLGIHTG 662
Query: 234 DSATSIPPYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQ--NNEVYVLEVNPRASR 291
DS P +LS E ++E K+ LE+ G N+QYA+ + E ++EVN R SR
Sbjct: 663 DSVVVAPSQTLSNEEYHMLRETAIKVVRHLEIVGECNIQYALHPLSLEYCIIEVNARLSR 722
Query: 292 TVPFVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKE 351
+ SK+ GYPLA +A K+A+G L +I V + F P I + K
Sbjct: 723 SSALASKATGYPLAFVAAKLALGIPLPDIKNAV-------SGKTTACFEPSLDYIVT-KI 774
Query: 352 VVFPWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKA 390
+ RF +G MKS GEVM I + F ++ KA
Sbjct: 775 PRWDLDRFHGASREIGSSMKSVGEVMAIGRTFEESFQKA 813
sp|P07756|CPSM_RAT CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL PRECURSOR
(CARBAMOYL-PHOSPHATE SYNTHETASE I) (CPSASE I)
>gi|68265|pir||SYRTCA carbamoyl-phosphate synthase
(ammonia) (EC 6.3.4.16) I precursor - rat >gi|203576
(M12335) carbamyl phosphate synthetase [Rattus
norvegicus]
Length = 1500
Score = 371 bits (942), Expect = e-102
Identities = 205/520 (39%), Positives = 304/520 (58%), Gaps = 21/520 (4%)
Query: 5 VVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEPI 64
+++LG GP IG +EFD+ V ++ +L++ G V+VNCNPETVSTD+D DKLYFE +
Sbjct: 976 IMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDKLYFEEL 1035
Query: 65 VFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFREL 124
E ++DI +E G I+ GGQ P LA+PL KNGVKI+GT P ID+AEDR +F +
Sbjct: 1036 SLERILDIYHQEACNGCIISVGGQIPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAV 1095
Query: 125 IIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXXXA 184
+ EL + Q P T EAL+ A +G+P L+RPSYVL G AM +V+ A
Sbjct: 1096 LDELKVAQAPWKAVNTLNEALEFANSVGYPCLLRPSYVLSGSAMNVVFSEDEMKRFLEEA 1155
Query: 185 VSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPYSL 244
VS E PV++ KF++ + E+++DAV V+ A+ EH+E+AGVHSGD+ +P ++
Sbjct: 1156 TRVSQEHPVVLTKFIEGAREVEMDAVGKEGRVISHAISEHVEDAGVHSGDATLMLPTQTI 1215
Query: 245 SKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGYPL 304
S+ +E+VK+ TRK+A A + G NVQ+ V+ N+V V+E N RASR+ PFVSK++G
Sbjct: 1216 SQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLVIECNLRASRSFPFVSKTLGVDF 1275
Query: 305 AKIATKVAIGKSLRE-ILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEVD 363
+ATKV IG+S+ E LP + + + SD++ ++K +F W R + D
Sbjct: 1276 IDVATKVMIGESVDEKHLPTLEQPI------IPSDYV-------AIKAPMFSWPRLRDAD 1322
Query: 364 PILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILELAKEF 423
PIL EM STGEV + A+ KA LS G+++P+KG + I + +P+ L +A++
Sbjct: 1323 PILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKIPQKG-ILIGIQQSFRPRFLGVAEQL 1381
Query: 424 EKLGFGIYATSGTYKFLKEHGVNAKRVLKVSEGRPN-----VVDMIINGEIHLVINTPSG 478
GF ++AT T +L + V A V S+ N + +I +G I LVIN P+
Sbjct: 1382 HNEGFKLFATEATSDWLNANNVPATPVAWPSQEGQNPSLSSIRKLIRDGSIDLVINLPNN 1441
Query: 479 KRE-KSDAYYIRRACVQFNVPYYTTMRAGYAVLEAIKSIK 517
+ D Y IRR V + T + EA++ +
Sbjct: 1442 NTKFVHDNYVIRRTAVDSGIALLTNFQVTKLFAEAVQKAR 1481
Score = 202 bits (508), Expect = 7e-51
Identities = 138/399 (34%), Positives = 215/399 (53%), Gaps = 22/399 (5%)
Query: 4 KVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTD---YDTADKLY 60
KV+ILGSG IGQ EFDY+ AV +++EE V++N N +V T+ AD +Y
Sbjct: 424 KVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNEVGLKQADAVY 483
Query: 61 FEPIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGV------KILGTKPESIDK 114
F PI + V ++I+ E+P+G+IL GGQT L + L K GV K+LGT ESI
Sbjct: 484 FLPITPQFVTEVIKAERPDGLILGMGGQTALNCGVELFKRGVLKEYGVKVLGTSVESIMA 543
Query: 115 AEDRELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDX 174
EDR+LF + + E+ K PS + E+ALK A IG+PV++R +Y LGG I +
Sbjct: 544 TEDRQLFSDKLNEINEKIAPSFAVESMEDALKAADTIGYPVMIRSAYALGGLGSGICPNK 603
Query: 175 XXXXXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAV-MEHIEEAGVHSG 233
A +++++ +L+++ + E++ + V D D + ME+++ GVH+G
Sbjct: 604 ETLMDLGTKAFAMTNQ--ILVERSVTGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTG 661
Query: 234 DSATSIPPYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQ--NNEVYVLEVNPRASR 291
DS P +LS + ++ + + L + G N+Q+A+ + E ++EVN R SR
Sbjct: 662 DSVVVAPAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSR 721
Query: 292 TVPFVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKE 351
+ SK+ GYPLA IA K+A+G L EI + + G+ ++ F P + + K
Sbjct: 722 SSALASKATGYPLAFIAAKIALGIPLPEI-----KNVVSGKT--SACFEPSLDYMVT-KI 773
Query: 352 VVFPWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKA 390
+ RF +G MKS GEVM I + F ++ KA
Sbjct: 774 PRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQKA 812
sp|P31327|CPSM_HUMAN CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL PRECURSOR
(CARBAMOYL-PHOSPHATE SYNTHETASE I) (CPSASE I)
>gi|3228248|emb|CAA75785| (Y15793) carbamoyl phosphate
synthetase 1 [Homo sapiens] >gi|5020420|gb|AAD38072.1|
(AF154830) carbamyl phosphate synthetase I [Homo sapiens]
Length = 1500
Score = 370 bits (941), Expect = e-101
Identities = 205/522 (39%), Positives = 306/522 (58%), Gaps = 21/522 (4%)
Query: 5 VVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEPI 64
+++LG GP IG +EFD+ V ++ +L++ G V+VNCNPETVSTD+D DKLYFE +
Sbjct: 976 MMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDKLYFEEL 1035
Query: 65 VFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFREL 124
E ++DI +E G I+ GGQ P LA+PL KNGVKI+GT P ID+AEDR +F +
Sbjct: 1036 SLERILDIYHQEACGGCIISVGGQIPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAV 1095
Query: 125 IIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXXXA 184
+ EL + Q P T EAL+ AK + +P L+RPSYVL G AM +V+ A
Sbjct: 1096 LDELKVAQAPWKAVNTLNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDEMKKFLEEA 1155
Query: 185 VSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPYSL 244
VS E PV++ KF++ + E+++DAV V+ A+ EH+E+AGVHSGD+ +P ++
Sbjct: 1156 TRVSQEHPVVLTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLMLPTQTI 1215
Query: 245 SKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGYPL 304
S+ +E+VK+ TRK+A A + G NVQ+ V+ N+V V+E N RASR+ PFVSK++G
Sbjct: 1216 SQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLVIECNLRASRSFPFVSKTLGVDF 1275
Query: 305 AKIATKVAIGKSLRE-ILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEVD 363
+ATKV IG+++ E LP + + +D++ ++K +F W R + D
Sbjct: 1276 IDVATKVMIGENVDEKHLPTLDHPI------IPADYV-------AIKAPMFSWPRLRDAD 1322
Query: 364 PILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILELAKEF 423
PIL EM STGEV + A+ KA LS G+++P+KG + I + +P+ L +A++
Sbjct: 1323 PILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKIPQKG-ILIGIQQSFRPRFLGVAEQL 1381
Query: 424 EKLGFGIYATSGTYKFLKEHGVNAKRVLKVSEGRPN-----VVDMIINGEIHLVINTPSG 478
GF ++AT T +L + V A V S+ N + +I +G I LVIN P+
Sbjct: 1382 HNEGFKLFATEATSDWLNANNVPATPVAWPSQEGQNPSLSSIRKLIRDGSIDLVINLPNN 1441
Query: 479 KRE-KSDAYYIRRACVQFNVPYYTTMRAGYAVLEAIKSIKKL 519
+ D Y IRR V +P T + EA++ +K+
Sbjct: 1442 NTKFVHDNYVIRRTAVDSGIPLLTNFQVTKLFAEAVQKSRKV 1483
Score = 202 bits (509), Expect = 5e-51
Identities = 139/399 (34%), Positives = 215/399 (53%), Gaps = 22/399 (5%)
Query: 4 KVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTD---YDTADKLY 60
KV+ILGSG IGQ EFDY+ AV +++EE V++N N +V T+ AD +Y
Sbjct: 424 KVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNEVGLKQADTVY 483
Query: 61 FEPIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGV------KILGTKPESIDK 114
F PI + V ++I+ E+P+G+IL GGQT L + L K GV K+LGT ESI
Sbjct: 484 FLPITPQFVTEVIKAEQPDGLILGMGGQTALNCGVELFKRGVLKEYGVKVLGTSVESIMA 543
Query: 115 AEDRELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDX 174
EDR+LF + + E+ K PS + E+ALK A IG+PV++R +Y LGG I +
Sbjct: 544 TEDRQLFSDKLNEINEKIAPSFAVESIEDALKAADTIGYPVMIRSAYALGGLGSGICPNR 603
Query: 175 XXXXXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAV-MEHIEEAGVHSG 233
A +++++ +L++K + E++ + V D D + ME+++ GVH+G
Sbjct: 604 ETLMDLSTKAFAMTNQ--ILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTG 661
Query: 234 DSATSIPPYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQ--NNEVYVLEVNPRASR 291
DS P +LS + ++ + + L + G N+Q+A+ + E ++EVN R SR
Sbjct: 662 DSVVVAPAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSR 721
Query: 292 TVPFVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKE 351
+ SK+ GYPLA IA K+A+G L EI + + G+ ++ F P + + K
Sbjct: 722 SSALASKATGYPLAFIAAKIALGIPLPEI-----KNVVSGKT--SACFEPSLDYMVT-KI 773
Query: 352 VVFPWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKA 390
+ RF +G MKS GEVM I + F ++ KA
Sbjct: 774 PRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQKA 812
gb|AAD51318.2| (AF169248) acetylglutamate-activated carbamoyl phosphate synthase III
[Opsanus beta]
Length = 1504
Score = 369 bits (938), Expect = e-101
Identities = 207/520 (39%), Positives = 300/520 (56%), Gaps = 20/520 (3%)
Query: 6 VILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEPIV 65
++LG GP IG +EFD+ V ++ +L++ G V+VN NPETVSTD+D D+LYFE +
Sbjct: 977 MVLGCGPYHIGSSVEFDWCAVSSIRALRQMGKKTVVVNHNPETVSTDFDECDRLYFEELT 1036
Query: 66 FEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFRELI 125
E ++DI ++E G I+ GGQ P LA+PL KNGVKILGT P ID+AE+R F +++
Sbjct: 1037 LERILDISQQEGCVGTIVSVGGQIPNNLAVPLHKNGVKILGTSPVQIDRAEERSTFSKIL 1096
Query: 126 IELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXXXAV 185
+LG+ Q P + ++A A +G+P L+RPSYVL G AM + Y A
Sbjct: 1097 DDLGVAQAPWSAVNSLDDAFTFANRVGYPCLLRPSYVLSGSAMNVAYGEEEMKRFLEEAA 1156
Query: 186 SVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPYSLS 245
VS E PV+I KF+ + E+++DAV+ VL A+ EH+E+AGVHSGD+ +P ++S
Sbjct: 1157 QVSQEHPVVITKFICGAREVEMDAVAKNGKVLCHAITEHVEDAGVHSGDATLMLPTQTIS 1216
Query: 246 KEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGYPLA 305
+ +E+VK TRK+A ALE+ G N Q+ V+ N+V V+E N RASR+ PFVSK+IG
Sbjct: 1217 QGALEKVKIATRKIAHALEISGPFNTQFLVKGNDVMVIECNLRASRSFPFVSKTIGVDFI 1276
Query: 306 KIATKVAIGKSLRE-ILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEVDP 364
K+ATKV G+ L E LP + + +P + +K +F W R E DP
Sbjct: 1277 KVATKVMTGEPLDESSLPSL-----------ENPIIPVD--YVGIKAPMFSWPRLREADP 1323
Query: 365 ILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILELAKEFE 424
+L EM STGEV A+ KA LS G++LP+KG + I + +P L A++ +
Sbjct: 1324 VLRCEMASTGEVACFGPNIYSAFLKAMLSTGFKLPQKG-ILIGIQHSFRPHFLATAQQLK 1382
Query: 425 KLGFGIYATSGTYKFLKEHGVNAKRVLKVSEGR----PNVVDMIINGEIHLVINTPSGK- 479
GF +YAT T +L + V + V S+ P++ +I G I LV+N P+
Sbjct: 1383 DEGFKLYATEATSAWLCANDVPSTPVAWPSDNADSNLPSIKRLISEGHIDLVVNLPNNNT 1442
Query: 480 REKSDAYYIRRACVQFNVPYYTTMRAGYAVLEAIKSIKKL 519
R+ D + IRR + + VP T + EAI S + L
Sbjct: 1443 RQVKDNFLIRRMAIDYGVPLITNDQVVKLFAEAIHSARSL 1482
Score = 210 bits (528), Expect = 3e-53
Identities = 152/447 (34%), Positives = 233/447 (52%), Gaps = 35/447 (7%)
Query: 4 KVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDY---DTADKLY 60
KV++LGSG IGQ EFDY+ AV +++EE V++N N +V T+ AD +Y
Sbjct: 424 KVLVLGSGGLSIGQAGEFDYSGSQAVKAMKEENLQTVLMNPNIASVQTNEVGTKQADSVY 483
Query: 61 FEPIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPL------QKNGVKILGTKPESIDK 114
F P+ E V ++I+ E+P+G++L GGQT L + L +K GV++LGT ESI
Sbjct: 484 FLPVTPEFVTEVIKIERPDGILLSMGGQTALNCGVELFRRGILKKYGVQVLGTSVESIMA 543
Query: 115 AEDRELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDX 174
EDR+LF + ++E+ K PS T +ALK A++IG+PV++R +Y LGG +
Sbjct: 544 TEDRQLFSDKLVEINEKIAPSIAVETVPDALKAAEQIGYPVMIRSAYALGGLGSGLCATK 603
Query: 175 XXXXXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAV-MEHIEEAGVHSG 233
A+++S + +L++K L E++ + V D D + ME+ + G+H+G
Sbjct: 604 EKLEDMAQKALAMSSQ--ILVEKSLLGWKEVEYEVVRDVADNCVTVCNMENFDPLGIHTG 661
Query: 234 DSATSIPPYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQ--NNEVYVLEVNPRASR 291
DS P +LS E +++E K+ L + G N+QYA+ + E ++EVN R SR
Sbjct: 662 DSIVVAPSQTLSNEEYHKLRETAIKVVRHLGIVGECNIQYALHPTSLEYCIIEVNARLSR 721
Query: 292 TVPFVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKE 351
+ SK+ GYPLA +A K+A+G L EI V ++ + F P I + K
Sbjct: 722 SSALASKATGYPLAFVAAKLALGIPLPEIKNAVSQKT-------TACFEPSLDYIVT-KI 773
Query: 352 VVFPWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKAQLSA-----GY--RLP----- 399
+ RF + +G MKS GEVM I + F + KA G+ RLP
Sbjct: 774 PRWDLDRFQGMSREIGSSMKSVGEVMAIGRTFEESIQKALRMCHPSIDGFMPRLPLKKDW 833
Query: 400 -EKGNLFISVADRDKPKILELAKEFEK 425
+ +L +A +I LAK F K
Sbjct: 834 ADSHDLQQDLAVPSSTRIFSLAKAFHK 860
gi|2245664 (AF006491) carbamoyl-phosphate synthetase III; CPSase III
[Micropterus salmoides]
Length = 1506
Score = 369 bits (936), Expect = e-101
Identities = 207/516 (40%), Positives = 299/516 (57%), Gaps = 21/516 (4%)
Query: 5 VVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEPI 64
+++LG GP IG +EFD+ V ++ +L++ G V+VN NPETVSTD+D D+LYFE +
Sbjct: 977 IMVLGCGPYHIGSSVEFDWCAVSSIRALRQMGKKTVVVNHNPETVSTDFDECDRLYFEEL 1036
Query: 65 VFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFREL 124
E ++DI ++E G I+ GGQ P LA PL NGVKILGT P ID+AE+R +F +
Sbjct: 1037 TLERILDITQQEGCSGSIVSVGGQIPNNLAAPLHLNGVKILGTSPLQIDRAEERSVFSNI 1096
Query: 125 IIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXXXA 184
+ +LG+ Q P + E+A A ++G+P L+RPSYVL G AM +VY A
Sbjct: 1097 LDDLGVAQAPWRALSSLEDAFTFANQVGYPCLLRPSYVLSGSAMNVVYGEEEMKRFLEEA 1156
Query: 185 VSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPYSL 244
VS + PV+I KF+ + E++VDAV+ G VL+ A+ EH+E+AGVHSGD+ +P S+
Sbjct: 1157 TQVSQDHPVVITKFIRGAREVEVDAVAKGGKVLVHAITEHVEDAGVHSGDATLMLPTQSI 1216
Query: 245 SKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGYPL 304
S+ +E+VK TRK+A A E+ G N Q+ V+ ++V V+E N RASR+ PFVSK+IG L
Sbjct: 1217 SQGALEKVKTATRKIAQAFEISGPFNTQFLVKGSDVMVIECNLRASRSFPFVSKTIGVDL 1276
Query: 305 AKIATKVAIGKSLREI-LPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEVD 363
+ATKV +G+ L E LP + + + DF+ +K +F W R + D
Sbjct: 1277 INVATKVMVGEPLDEANLPSLDKPI------IPMDFV-------GIKAPMFSWPRLRDAD 1323
Query: 364 PILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILELAKEF 423
P+L EM STGEV A+ KA LS G++LP+KG + I + +P L A
Sbjct: 1324 PVLRCEMASTGEVACFGPNIYSAFLKAMLSTGFKLPQKG-ILIGIQHSFRPNFLATAHHL 1382
Query: 424 EKLGFGIYATSGTYKFLKEHGVNAKRVLKVSE-----GRPNVVDMIINGEIHLVINTP-S 477
++ GF +YAT T +L + V A V +E P++ +I G+I LV+N P +
Sbjct: 1383 KEEGFKLYATEATSAWLCANDVPATPVAWPTEKGGDTSLPSIKRLINEGDIDLVVNLPNN 1442
Query: 478 GKREKSDAYYIRRACVQFNVPYYTTMRAGYAVLEAI 513
R D + IRR + VP T + EAI
Sbjct: 1443 NSRHLRDNFLIRRMAIDHAVPLITNYQVVKLFAEAI 1478
Score = 207 bits (521), Expect = 2e-52
Identities = 138/399 (34%), Positives = 215/399 (53%), Gaps = 22/399 (5%)
Query: 4 KVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDY---DTADKLY 60
KV++LGSG IGQ EFDY+ A+ +++EE V++N N +V T+ AD +Y
Sbjct: 425 KVLVLGSGGLSIGQAGEFDYSGSQAIKAMKEENVQTVLMNPNIASVQTNEVGTKQADSVY 484
Query: 61 FEPIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPL------QKNGVKILGTKPESIDK 114
F P+ + V ++I+ E+P+G++L GGQT L + L +K GVK+LGT ESI
Sbjct: 485 FLPVTPQFVTEVIKNERPDGILLSMGGQTALNCGVELFQRGILEKYGVKVLGTPVESIMA 544
Query: 115 AEDRELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDX 174
EDR+LF + ++E+ K PS + +ALK A++IG+PV++R +Y LG + D
Sbjct: 545 TEDRQLFADKLMEINEKIAPSFAVESVTDALKAAEQIGYPVMLRSAYALGPLGSGLCADK 604
Query: 175 XXXXXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAV-MEHIEEAGVHSG 233
A+++S + +L++K L E++ + V D D + ME+ + G+H+G
Sbjct: 605 EKLEETAHKALAMSSQ--ILVEKSLMGWKEVEYEVVRDVADNCVTVCNMENFDPLGIHTG 662
Query: 234 DSATSIPPYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNN--EVYVLEVNPRASR 291
DS P +LS E ++E K+ L + G N+QYA+ + E ++EVN R SR
Sbjct: 663 DSIVVAPSQTLSNEEYHMLRETAIKVVRHLGIIGECNIQYALHPSSLEYCIIEVNARLSR 722
Query: 292 TVPFVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKE 351
+ SK+ GYPLA +A K+A+G L EI V E+ + F P I + K
Sbjct: 723 SSALASKATGYPLAFVAAKLALGIPLPEIKNAVSEKT-------TACFEPSLDYIVT-KI 774
Query: 352 VVFPWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKA 390
+ RF + +G MKS GEVM + + F + KA
Sbjct: 775 PRWDLDRFHGMSHEIGSAMKSVGEVMAVGRTFEESMQKA 813
gi|4185560 (AF112473) PyrABCN [Emericella nidulans]
Length = 2275
Score = 367 bits (931), Expect = e-100
Identities = 212/523 (40%), Positives = 300/523 (56%), Gaps = 33/523 (6%)
Query: 5 VVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEPI 64
+++LGSG RIG +EFD+ V + +L+E+G+ VMVN NPETVSTDYD AD+LYFE I
Sbjct: 1022 IMVLGSGVYRIGSSVEFDWCSVRTIRTLREQGHKTVMVNYNPETVSTDYDEADRLYFENI 1081
Query: 65 VFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFREL 124
E V+DI + E GVI+ GGQTP +ALPL + V+ILGT PE ID AE+R F +
Sbjct: 1082 NLETVLDIYQLESSSGVIMSMGGQTPNNIALPLHRLNVRILGTSPEMIDGAENRYKFSRM 1141
Query: 125 IIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXXXA 184
+ +G+ QP + EEA + ++G+PVLVRPSYVL G AM VY A
Sbjct: 1142 LDRIGVDQPAWKELTSIEEAREFCDKVGYPVLVRPSYVLSGAAMNTVYSEHDLASYLNQA 1201
Query: 185 VSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPYSL 244
VS E PV+I K+++N+ E+++DAV+ ++ + EH+E AGVHSGD+ +PP L
Sbjct: 1202 ADVSREHPVVITKYIENAKEIEMDAVARNGVMVGHFISEHVENAGVHSGDATLILPPQDL 1261
Query: 245 SKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGYPL 304
E V ++E TRK+ AL V G N+Q+ ++N++ V+E N RASR+ PFVSK +G L
Sbjct: 1262 DPETVRRIEEATRKIGNALNVTGPFNIQFIAKDNDIKVIECNVRASRSFPFVSKVMGVDL 1321
Query: 305 AKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEVDP 364
++ATK IG E P +PK+ VK F + R DP
Sbjct: 1322 IEMATKAMIGAPFAEYPPVT---------------IPKD--YVGVKVPQFSFSRLAGADP 1364
Query: 365 ILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVAD-RDKPKILELAKEF 423
+LG EM STGEV ++ AY KA LS G++LP K N+ +S+ ++K ++L +
Sbjct: 1365 VLGVEMASTGEVASFGRDKYEAYLKALLSTGFKLP-KRNILLSIGSYKEKMEMLPSIIKL 1423
Query: 424 EKLGFGIYATSGTYKFLKEHGVNAKRVLKVSEGRP-------NVVDMIINGEIHLVINTP 476
+GF ++ATSGT FLKE+GV K L++ G ++ + N I L IN P
Sbjct: 1424 RDVGFELFATSGTADFLKENGVPVK-YLEILPGEDEDIKSEYSLTQHLANNLIDLYINLP 1482
Query: 477 SGKREKSDAYYI------RRACVQFNVPYYTTMRAGYAVLEAI 513
S R + A Y+ RR V + P T ++ ++EAI
Sbjct: 1483 SSNRFRRPANYMSKGYRTRRMAVDYQTPLVTNVKNAKILIEAI 1525
Score = 217 bits (547), Expect = 2e-55
Identities = 145/401 (36%), Positives = 212/401 (52%), Gaps = 17/401 (4%)
Query: 3 KKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFE 62
KKV+ILGSG IGQ EFDY+ A+ +L+EEG Y +++N N T+ T ADK+YF
Sbjct: 481 KKVLILGSGGLSIGQAGEFDYSGSQAIKALKEEGIYTILINPNIATIQTSKGLADKVYFL 540
Query: 63 PIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKN----GVKILGTKPESIDKAEDR 118
P+ + V +I+ E+P+ + + FGGQT L++ + L+ GVK+LGT ++I EDR
Sbjct: 541 PVNADFVRKVIKHERPDAIYVTFGGQTALQVGIQLKDEFESLGVKVLGTPIDTIITTEDR 600
Query: 119 ELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXX 178
ELF + +G K S +A + EEAL++ + IGFPV+VR +Y LGG +
Sbjct: 601 ELFARSMDSIGEKCAKSASASSLEEALQVVESIGFPVIVRAAYALGGLGSGFADNLDELK 660
Query: 179 XXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAV-MEHIEEAGVHSGDSAT 237
A + S + VLI++ + E++ + V D +D I ME+ + G+H+GDS
Sbjct: 661 DLCAKAFAASPQ--VLIERSMKGWKEIEYEVVRDARDNCITVCNMENFDPLGIHTGDSIV 718
Query: 238 SIPPYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQ--NNEVYVLEVNPRASRTVPF 295
P +LS E ++ + L V G N+QYA+ + E ++EVN R SR+
Sbjct: 719 VAPSQTLSDEDYNMLRTTAVNVIRHLGVVGECNIQYALNPYSKEYCIIEVNARLSRSSAL 778
Query: 296 VSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFP 355
SK+ GYPLA IA K+ + L EI V + + F P VK +
Sbjct: 779 ASKATGYPLAFIAAKLGLNIPLNEIKNSVTKVT-------CACFEP-SLDYCVVKIPRWD 830
Query: 356 WKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGY 396
K+F V LG MKS GEVM I + F A KA S +
Sbjct: 831 LKKFTRVSTQLGSSMKSVGEVMAIGRTFEEAIQKAIRSVDF 871
sp|Q91293|CPSM_RANCA CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL PRECURSOR
(CARBAMOYL-PHOSPHATE SYNTHETASE I) (CPSASE I)
>gi|2118284|pir||I51170 carbamyl phosphate synthetase -
bullfrog >gi|467223 (U05193) carbamyl phosphate
synthetase [Rana catesbeiana]
Length = 1496
Score = 366 bits (929), Expect = e-100
Identities = 203/515 (39%), Positives = 294/515 (56%), Gaps = 18/515 (3%)
Query: 5 VVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEPI 64
+++LG GP IG +EFD+ V ++ +L+ G V+VNCNPETVSTD+D DKLYFE +
Sbjct: 973 MMVLGCGPYHIGSSVEFDWCAVSSIRTLRHVGKKTVVVNCNPETVSTDFDECDKLYFEEL 1032
Query: 65 VFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFREL 124
E +MD+ + E+ +G I+ GGQ P LA+PL KNGVKI+GT P ID+AEDR +F +
Sbjct: 1033 SQERIMDVFQLEQCDGCIISVGGQIPNNLAVPLYKNGVKIMGTSPMQIDRAEDRSIFSAV 1092
Query: 125 IIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXXXA 184
+ EL + Q P + ++AL+ K +G+P L+RPSYVL G AM +VY A
Sbjct: 1093 LDELQIAQAPWKAVNSLDDALQFTKTVGYPCLLRPSYVLSGSAMNVVYGEEELKTFLAEA 1152
Query: 185 VSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPYSL 244
VS E PV+I KF++ + E+++DAV V+ A+ EH+E+AGVHSGD+ IP S+
Sbjct: 1153 TRVSQEHPVVITKFIEGAREVEMDAVGKEGRVISHAISEHVEDAGVHSGDATLMIPTQSI 1212
Query: 245 SKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGYPL 304
S+ +E+VK T+K+A A + G NVQ+ V+ N+V V+E N RASR+ PFVSK++G
Sbjct: 1213 SQGAIEKVKIATKKIATAFAISGPFNVQFLVRGNDVLVIECNLRASRSFPFVSKTLGVDF 1272
Query: 305 AKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEVDP 364
+ATKV IG+ + E ER +P + +K +F W R DP
Sbjct: 1273 IDVATKVMIGEKIDESSLPTLER----------PVIPAD--YVGIKAPMFSWPRLRGADP 1320
Query: 365 ILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILELAKEFE 424
+L EM STGEV + A+ KA +S G++LP+KG + I + +P L A+ +
Sbjct: 1321 VLKCEMASTGEVACFGQNVYSAFLKAMISTGFKLPQKG-ILIGIQHSFRPHFLGTAQTLK 1379
Query: 425 KLGFGIYATSGTYKFLKEHGVNAKRVLKVSE----GRPNVVDMIINGEIHLVINTPSGK- 479
GF +YAT T +L + + A V S+ G ++ +I G I +VIN P+
Sbjct: 1380 DEGFKLYATEATADWLNANDITATPVAWPSQEGQSGPSSIYKLIKEGNIDMVINLPNNNT 1439
Query: 480 REKSDAYYIRRACVQFNVPYYTTMRAGYAVLEAIK 514
+ D + IRR V T + EAIK
Sbjct: 1440 KYVRDNFAIRRTAVDTGTALLTNFQVVKMFAEAIK 1474
Score = 198 bits (499), Expect = 8e-50
Identities = 136/399 (34%), Positives = 217/399 (54%), Gaps = 22/399 (5%)
Query: 4 KVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTD---YDTADKLY 60
KV+ILGSG IGQ EFDY+ AV +++EE V++N N +V T+ AD +Y
Sbjct: 421 KVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNEVGLKQADTVY 480
Query: 61 FEPIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGV------KILGTKPESIDK 114
F PI + V ++I+ EK +G+IL GGQT L + L K GV ++LGT ESI
Sbjct: 481 FLPITPQFVTEVIKAEKTDGIILGMGGQTALNCGVELFKRGVLKEYGVRVLGTSVESIMF 540
Query: 115 AEDRELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDX 174
EDR+LF + + E+ PS + ++AL+ A +IG+PV++R +Y LGG + D
Sbjct: 541 TEDRQLFSDKLNEIKEPIAPSFAVESVKDALEAADKIGYPVMIRSAYALGGLGSGLCPDK 600
Query: 175 XXXXXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAV-MEHIEEAGVHSG 233
A++++++ +L+++ + E++ + V D D + ME+++ GVH+G
Sbjct: 601 ETLTDLATKALAMTNQ--ILVERSVVGWKEIEYEVVRDAADNCVTVCNMENVDAMGVHTG 658
Query: 234 DSATSIPPYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQ--NNEVYVLEVNPRASR 291
DS P +LS E + ++ + K+ L + G N+Q+A+ + E ++EVN R SR
Sbjct: 659 DSIVVAPCQTLSNEECQMLRAVSIKVVRHLGIVGECNIQFALHPTSLEYVIIEVNARLSR 718
Query: 292 TVPFVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKE 351
+ SK+ GYPLA IA K+A+G L EI + + G+ + F P + + K
Sbjct: 719 SSALASKATGYPLAFIAAKIALGIPLPEI-----KNVVSGKT--TACFEPSLDYMVT-KI 770
Query: 352 VVFPWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKA 390
+ RF ++G MKS GEVM I + F ++ KA
Sbjct: 771 PRWDLDRFHGASGLIGSSMKSVGEVMAIGRTFEESFQKA 809
gi|1518088 (U65893) carbamoyl-phosphate synthetase III [Oncorhynchus mykiss]
Length = 1518
Score = 365 bits (927), Expect = e-100
Identities = 207/522 (39%), Positives = 297/522 (56%), Gaps = 21/522 (4%)
Query: 5 VVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEPI 64
V++LG GP IG +EFD+ V ++ +L++ G V+VN NPETVSTD+D D+LYFE +
Sbjct: 974 VMVLGCGPYHIGSSVEFDWCAVSSIRALRQMGMRTVVVNHNPETVSTDFDECDRLYFEEL 1033
Query: 65 VFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFREL 124
E ++DI ++E G I+ GGQ P LA+PL NGVKILGT P+ ID+AE+R +F +
Sbjct: 1034 TLERILDITQQEGCTGSIVSVGGQIPNNLAMPLHLNGVKILGTNPQQIDRAEERSVFSTI 1093
Query: 125 IIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXXXA 184
+ ELG+ Q P + E+A A ++G+P L+RPSYVL G AM + Y A
Sbjct: 1094 LDELGVAQAPWKALSSLEDAFAFANKVGYPCLLRPSYVLSGSAMNVAYGEEEMRGFLDEA 1153
Query: 185 VSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPYSL 244
VS E PV+I KF+ + E++VDAV+ VL A+ EH+E+AGVHSGD+ +P S+
Sbjct: 1154 TQVSQEHPVVITKFIRGAREVEVDAVAKMGKVLCHAITEHVEDAGVHSGDATLMLPTQSI 1213
Query: 245 SKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGYPL 304
S+ +E+VK TRK+A A E+ G N Q+ V+ N+V V+E N RASR+ PFVSK+IG
Sbjct: 1214 SQGALEKVKSATRKIAKAFEISGPFNTQFLVKGNDVMVIECNLRASRSFPFVSKTIGVDF 1273
Query: 305 AKIATKVAIGKSLRE-ILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEVD 363
+AT+V +G+ E LP + + +P + +K +F W R + D
Sbjct: 1274 ISVATRVMVGEPQDEAALPSL-----------ENPIIPVD--YVGIKAPMFSWPRLRDAD 1320
Query: 364 PILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILELAKEF 423
P+L EM STGEV A+ KA LS G++LP KG + I + +P L A +
Sbjct: 1321 PVLRCEMASTGEVACFGPNIYSAFLKAMLSTGFKLPTKG-ILIGIQHSFRPNFLATAHQL 1379
Query: 424 EKLGFGIYATSGTYKFLKEHGVNAKRVLKVSE-----GRPNVVDMIINGEIHLVINTPSG 478
+ GF ++AT T +L + V A V S+ P+++ +I G I LVIN P+
Sbjct: 1380 NEEGFKLFATEATSAWLSANDVPATPVAWPSQEGGDASLPSIIRLINEGHIDLVINLPNN 1439
Query: 479 KRE-KSDAYYIRRACVQFNVPYYTTMRAGYAVLEAIKSIKKL 519
+ D + IRR V VP T + EAIK +L
Sbjct: 1440 NSKFLRDNFLIRRMAVDHGVPLITNHQVVKLFAEAIKYASEL 1481
Score = 203 bits (512), Expect = 2e-51
Identities = 140/399 (35%), Positives = 212/399 (53%), Gaps = 22/399 (5%)
Query: 4 KVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDY---DTADKLY 60
KV++LGSG IGQ EFDY+ AV +++EE V++N N +V T+ AD +Y
Sbjct: 422 KVLVLGSGGLSIGQAGEFDYSGSQAVKAMKEENVRTVLMNPNIASVQTNEVGTKQADSVY 481
Query: 61 FEPIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPL------QKNGVKILGTKPESIDK 114
F P+ + V ++I+ E+P+G++L GGQT L + L QK GVK+LGT ESI
Sbjct: 482 FLPVTPQFVTEVIKTERPDGILLSMGGQTALNCGVELFQSGVLQKYGVKVLGTPVESIMA 541
Query: 115 AEDRELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDX 174
EDR+LF + + E+ K PS T ALK A +IG+PV++R +Y LGG +
Sbjct: 542 TEDRQLFADKLNEINEKIAPSFAVETVAGALKAADQIGYPVMLRSAYSLGGLGSGFCANK 601
Query: 175 XXXXXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSD-GKDVLIGAVMEHIEEAGVHSG 233
A+++S + +L++K L E++ + V D + + ME+ + G+H+G
Sbjct: 602 DKLEETARKALAMSCQ--ILVEKSLMGWKEVEYEVVRDIANNCVTVCNMENFDPLGIHTG 659
Query: 234 DSATSIPPYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQ--NNEVYVLEVNPRASR 291
DS P +LS E ++E K+ L + G N+QYA+ + E ++EVN R SR
Sbjct: 660 DSIVVAPSQTLSNEEYHMLRETAIKVVRHLGIVGECNIQYALHPGSLEYCIIEVNARLSR 719
Query: 292 TVPFVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKE 351
+ SK+ GYPLA +A K+A+G L EI V E+ + F P I + K
Sbjct: 720 SSALASKATGYPLAFVAAKLALGIPLPEIKNTVSEKT-------TACFEPSLDYIVT-KI 771
Query: 352 VVFPWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKA 390
+ RF + +G MKS GEVM + + F + KA
Sbjct: 772 PRWDLDRFQGMSREIGSSMKSVGEVMAVGRTFEESMQKA 810
ref|NP_012405.1|URA2| carbamoyl-phophate synthetase, aspartate transcarbamylase, and
glutamine amidotransferase; Ura2p
>gi|1172782|sp|P07259|PYR1_YEAST URA2 PROTEIN [INCLUDES:
GLUTAMINE-DEPENDENT CARBAMOYL-PHOSPHATE SYNTHASE ;
ASPARTATE CARBAMOYLTRANSFERASE ] >gi|1070511|pir||QZBYU2
pyrimidine synthesis protein URA2 - yeast (Saccharomyces
cerevisiae) >gi|1008332|emb|CAA89425| (Z49405) ORF
YJL130c [Saccharomyces cerevisiae]
Length = 2214
Score = 361 bits (918), Expect = 6e-99
Identities = 206/523 (39%), Positives = 305/523 (57%), Gaps = 33/523 (6%)
Query: 5 VVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEPI 64
V++LGSG RIG +EFD+ V AV +L+ +MVN NPETVSTDYD AD+LYFE I
Sbjct: 982 VMVLGSGVYRIGSSVEFDWCAVTAVRTLRANNIKTIMVNYNPETVSTDYDEADRLYFETI 1041
Query: 65 VFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFREL 124
E V+DI E E GV++ GGQT +A+ L + VKILGT P+ ID AE+R F +
Sbjct: 1042 NLERVLDIYEIENSSGVVVSMGGQTSNNIAMTLHRENVKILGTSPDMIDSAENRYKFSRM 1101
Query: 125 IIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXXXA 184
+ ++G+ QP + +EA A+++G+PVLVRPSYVL G AM VY A
Sbjct: 1102 LDQIGVDQPAWKELTSMDEAESFAEKVGYPVLVRPSYVLSGAAMNTVYSKNDLESYLNQA 1161
Query: 185 VSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPYSL 244
V VS + PV+I K+++N+ E+++DAV+ ++++ V EH+E AGVHSGD+ +PP L
Sbjct: 1162 VEVSRDYPVVITKYIENAKEIEMDAVARNGELVMHVVSEHVENAGVHSGDATLIVPPQDL 1221
Query: 245 SKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGYPL 304
+ E V+ + T K+ AL++ G N+Q+ ++NE+ V+E N RASR+ PF+SK +G L
Sbjct: 1222 APETVDRIVVATAKIGKALKITGPYNIQFIAKDNEIKVIECNVRASRSFPFISKVVGVNL 1281
Query: 305 AKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEVDP 364
++ATK +G LP +EK LP + V + FP R DP
Sbjct: 1282 IELATKAIMG------LPLTPYPVEK---------LPDDYVAVKVPQFSFP--RLAGADP 1324
Query: 365 ILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVAD-RDKPKILELAKEF 423
+LG EM STGEV AY K+ L+ G++LP+K N+ +S+ ++K ++L ++
Sbjct: 1325 VLGVEMASTGEVATFGHSKYEAYLKSLLATGFKLPKK-NILLSIGSYKEKQELLSSVQKL 1383
Query: 424 EKLGFGIYATSGTYKFLKEHGVNAKRVLKV-------SEGRPNVVDMIINGEIHLVINTP 476
+G+ ++ATSGT FL EHG+ A + L+V + ++ + N EI L IN P
Sbjct: 1384 YNMGYKLFATSGTADFLSEHGI-AVQYLEVLNKDDDDQKSEYSLTQHLANNEIDLYINLP 1442
Query: 477 SGKREKSDAYYI------RRACVQFNVPYYTTMRAGYAVLEAI 513
S R + A Y+ RR V ++VP T ++ ++EAI
Sbjct: 1443 SANRFRRPASYVSKGYKTRRLAVDYSVPLVTNVKCAKLLIEAI 1485
Score = 215 bits (541), Expect = 9e-55
Identities = 152/447 (34%), Positives = 220/447 (49%), Gaps = 33/447 (7%)
Query: 2 SKKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYF 61
+KKV++LGSG IGQ EFDY+ A+ +L+EEG Y +++N N T+ T ADK+YF
Sbjct: 438 AKKVLVLGSGGLSIGQAGEFDYSGSQAIKALKEEGIYTILINPNIATIQTSKGLADKVYF 497
Query: 62 EPIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKN----GVKILGTKPESIDKAED 117
P+ E V +I E+P+ + + FGGQT L + + ++ GVK+LGT ++I ED
Sbjct: 498 VPVTAEFVRKVILHERPDAIYVTFGGQTALSVGIAMKDEFEALGVKVLGTPIDTIITTED 557
Query: 118 RELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXX 177
RELF I E+ K S A + +EAL KEIGFPV+VR +Y LGG +
Sbjct: 558 RELFSNAIDEINEKCAKSQAANSVDEALAAVKEIGFPVIVRAAYALGGLGSGFANNEKEL 617
Query: 178 XXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAV-MEHIEEAGVHSGDSA 236
A S S + VL++K + E++ + V D D I ME+ + G+H+GDS
Sbjct: 618 VDLCNVAFSSSPQ--VLVEKSMKGWKEVEYEVVRDAFDNCITVCNMENFDPLGIHTGDSI 675
Query: 237 TSIPPYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQ--NNEVYVLEVNPRASRTVP 294
P +LS E ++ + L V G N+QYA+ + + ++EVN R SR+
Sbjct: 676 VVAPSQTLSDEDYNMLRTTAVNVIRHLGVVGECNIQYALNPVSKDYCIIEVNARLSRSSA 735
Query: 295 FVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVF 354
SK+ GYPLA A K+ + L E+ V + + F P VK +
Sbjct: 736 LASKATGYPLAYTAAKLGLNIPLNEVKNSVTKST-------CACFEP-SLDYCVVKMPRW 787
Query: 355 PWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRD-- 412
K+F V L MKS GEVM I + F A KA R E NL + D D
Sbjct: 788 DLKKFTRVSTELSSSMKSVGEVMSIGRTFEEAIQKA-----IRSTEYANLGFNETDLDID 842
Query: 413 ---------KPKILELAKEFEKLGFGI 430
++ +A F K G+ +
Sbjct: 843 IDYELNNPTDMRVFAIANAFAKKGYSV 869
emb|CAA60825| (X87371) carbamyl phosphate synthetase [Saccharomyces cerevisiae]
Length = 2040
Score = 361 bits (918), Expect = 6e-99
Identities = 206/523 (39%), Positives = 305/523 (57%), Gaps = 33/523 (6%)
Query: 5 VVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEPI 64
V++LGSG RIG +EFD+ V AV +L+ +MVN NPETVSTDYD AD+LYFE I
Sbjct: 808 VMVLGSGVYRIGSSVEFDWCAVTAVRTLRANNIKTIMVNYNPETVSTDYDEADRLYFETI 867
Query: 65 VFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFREL 124
E V+DI E E GV++ GGQT +A+ L + VKILGT P+ ID AE+R F +
Sbjct: 868 NLERVLDIYEIENSSGVVVSMGGQTSNNIAMTLHRENVKILGTSPDMIDSAENRYKFSRM 927
Query: 125 IIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXXXA 184
+ ++G+ QP + +EA A+++G+PVLVRPSYVL G AM VY A
Sbjct: 928 LDQIGVDQPAWKELTSMDEAESFAEKVGYPVLVRPSYVLSGAAMNTVYSKNDLESYLNQA 987
Query: 185 VSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPYSL 244
V VS + PV+I K+++N+ E+++DAV+ ++++ V EH+E AGVHSGD+ +PP L
Sbjct: 988 VEVSRDYPVVITKYIENAKEIEMDAVARNGELVMHVVSEHVENAGVHSGDATLIVPPQDL 1047
Query: 245 SKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGYPL 304
+ E V+ + T K+ AL++ G N+Q+ ++NE+ V+E N RASR+ PF+SK +G L
Sbjct: 1048 APETVDRIVVATAKIGKALKITGPYNIQFIAKDNEIKVIECNVRASRSFPFISKVVGVNL 1107
Query: 305 AKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEVDP 364
++ATK +G LP +EK LP + V + FP R DP
Sbjct: 1108 IELATKAIMG------LPLTPYPVEK---------LPDDYVAVKVPQFSFP--RLAGADP 1150
Query: 365 ILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVAD-RDKPKILELAKEF 423
+LG EM STGEV AY K+ L+ G++LP+K N+ +S+ ++K ++L ++
Sbjct: 1151 VLGVEMASTGEVATFGHSKYEAYLKSLLATGFKLPKK-NILLSIGSYKEKQELLSSVQKL 1209
Query: 424 EKLGFGIYATSGTYKFLKEHGVNAKRVLKV-------SEGRPNVVDMIINGEIHLVINTP 476
+G+ ++ATSGT FL EHG+ A + L+V + ++ + N EI L IN P
Sbjct: 1210 YNMGYKLFATSGTADFLSEHGI-AVQYLEVLNKDDDDQKSEYSLTQHLANNEIDLYINLP 1268
Query: 477 SGKREKSDAYYI------RRACVQFNVPYYTTMRAGYAVLEAI 513
S R + A Y+ RR V ++VP T ++ ++EAI
Sbjct: 1269 SANRFRRPASYVSKGYKTRRLAVDYSVPLVTNVKCAKLLIEAI 1311
Score = 215 bits (541), Expect = 9e-55
Identities = 152/447 (34%), Positives = 220/447 (49%), Gaps = 33/447 (7%)
Query: 2 SKKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYF 61
+KKV++LGSG IGQ EFDY+ A+ +L+EEG Y +++N N T+ T ADK+YF
Sbjct: 264 AKKVLVLGSGGLSIGQAGEFDYSGSQAIKALKEEGIYTILINPNIATIQTSKGLADKVYF 323
Query: 62 EPIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKN----GVKILGTKPESIDKAED 117
P+ E V +I E+P+ + + FGGQT L + + ++ GVK+LGT ++I ED
Sbjct: 324 VPVTAEFVRKVILHERPDAIYVTFGGQTALSVGIAMKDEFEALGVKVLGTPIDTIITTED 383
Query: 118 RELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXX 177
RELF I E+ K S A + +EAL KEIGFPV+VR +Y LGG +
Sbjct: 384 RELFSNAIDEINEKCAKSQAANSVDEALAAVKEIGFPVIVRAAYALGGLGSGFANNEKEL 443
Query: 178 XXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAV-MEHIEEAGVHSGDSA 236
A S S + VL++K + E++ + V D D I ME+ + G+H+GDS
Sbjct: 444 VDLCNVAFSSSPQ--VLVEKSMKGWKEVEYEVVRDAFDNCITVCNMENFDPLGIHTGDSI 501
Query: 237 TSIPPYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQ--NNEVYVLEVNPRASRTVP 294
P +LS E ++ + L V G N+QYA+ + + ++EVN R SR+
Sbjct: 502 VVAPSQTLSDEDYNMLRTTAVNVIRHLGVVGECNIQYALNPVSKDYCIIEVNARLSRSSA 561
Query: 295 FVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVF 354
SK+ GYPLA A K+ + L E+ V + + F P VK +
Sbjct: 562 LASKATGYPLAYTAAKLGLNIPLNEVKNSVTKST-------CACFEP-SLDYCVVKMPRW 613
Query: 355 PWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRD-- 412
K+F V L MKS GEVM I + F A KA R E NL + D D
Sbjct: 614 DLKKFTRVSTELSSSMKSVGEVMSIGRTFEEAIQKA-----IRSTEYANLGFNETDLDID 668
Query: 413 ---------KPKILELAKEFEKLGFGI 430
++ +A F K G+ +
Sbjct: 669 IDYELNNPTDMRVFAIANAFAKKGYSV 695
gi|173146 (M27174) carbamyl phosphate synthetase [Saccharomyces cerevisiae]
Length = 2214
Score = 361 bits (918), Expect = 6e-99
Identities = 206/523 (39%), Positives = 305/523 (57%), Gaps = 33/523 (6%)
Query: 5 VVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEPI 64
V++LGSG RIG +EFD+ V AV +L+ +MVN NPETVSTDYD AD+LYFE I
Sbjct: 982 VMVLGSGVYRIGSSVEFDWCAVTAVRTLRANNIKTIMVNYNPETVSTDYDEADRLYFETI 1041
Query: 65 VFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFREL 124
E V+DI E E GV++ GGQT +A+ L + VKILGT P+ ID AE+R F +
Sbjct: 1042 NLERVLDIYEIENSSGVVVSMGGQTSNNIAMTLHRENVKILGTSPDMIDSAENRYKFSRM 1101
Query: 125 IIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXXXA 184
+ ++G+ QP + +EA A+++G+PVLVRPSYVL G AM VY A
Sbjct: 1102 LDQIGVDQPAWKELTSMDEAESFAEKVGYPVLVRPSYVLSGAAMNTVYSKNDLESYLNQA 1161
Query: 185 VSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPYSL 244
V VS + PV+I K+++N+ E+++DAV+ ++++ V EH+E AGVHSGD+ +PP L
Sbjct: 1162 VEVSRDYPVVITKYIENAKEIEMDAVARNGELVMHVVSEHVENAGVHSGDATLIVPPQDL 1221
Query: 245 SKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGYPL 304
+ E V+ + T K+ AL++ G N+Q+ ++NE+ V+E N RASR+ PF+SK +G L
Sbjct: 1222 APETVDRIVVATAKIGKALKITGPYNIQFIAKDNEIKVIECNVRASRSFPFISKVVGVNL 1281
Query: 305 AKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEVDP 364
++ATK +G LP +EK LP + V + FP R DP
Sbjct: 1282 IELATKAIMG------LPLTPYPVEK---------LPDDYVAVKVPQFSFP--RLAGADP 1324
Query: 365 ILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVAD-RDKPKILELAKEF 423
+LG EM STGEV AY K+ L+ G++LP+K N+ +S+ ++K ++L ++
Sbjct: 1325 VLGVEMASTGEVATFGHSKYEAYLKSLLATGFKLPKK-NILLSIGSYKEKQELLSSVQKL 1383
Query: 424 EKLGFGIYATSGTYKFLKEHGVNAKRVLKV-------SEGRPNVVDMIINGEIHLVINTP 476
+G+ ++ATSGT FL EHG+ A + L+V + ++ + N EI L IN P
Sbjct: 1384 YNMGYKLFATSGTADFLSEHGI-AVQYLEVLNKDDDDQKSEYSLTQHLANNEIDLYINLP 1442
Query: 477 SGKREKSDAYYI------RRACVQFNVPYYTTMRAGYAVLEAI 513
S R + A Y+ RR V ++VP T ++ ++EAI
Sbjct: 1443 SANRFRRPASYVSKGYKTRRLAVDYSVPLVTNVKCAKLLIEAI 1485
Score = 215 bits (541), Expect = 9e-55
Identities = 152/447 (34%), Positives = 220/447 (49%), Gaps = 33/447 (7%)
Query: 2 SKKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYF 61
+KKV++LGSG IGQ EFDY+ A+ +L+EEG Y +++N N T+ T ADK+YF
Sbjct: 438 AKKVLVLGSGGLSIGQAGEFDYSGSQAIKALKEEGIYTILINPNIATIQTSKGLADKVYF 497
Query: 62 EPIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKN----GVKILGTKPESIDKAED 117
P+ E V +I E+P+ + + FGGQT L + + ++ GVK+LGT ++I ED
Sbjct: 498 VPVTAEFVRKVILHERPDAIYVTFGGQTALSVGIAMKDEFEALGVKVLGTPIDTIITTED 557
Query: 118 RELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXX 177
RELF I E+ K S A + +EAL KEIGFPV+VR +Y LGG +
Sbjct: 558 RELFSNAIDEINEKCAKSQAANSVDEALAAVKEIGFPVIVRAAYALGGLGSGFANNEKEL 617
Query: 178 XXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAV-MEHIEEAGVHSGDSA 236
A S S + VL++K + E++ + V D D I ME+ + G+H+GDS
Sbjct: 618 VDLCNVAFSSSPQ--VLVEKSMKGWKEVEYEVVRDAFDNCITVCNMENFDPLGIHTGDSI 675
Query: 237 TSIPPYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQ--NNEVYVLEVNPRASRTVP 294
P +LS E ++ + L V G N+QYA+ + + ++EVN R SR+
Sbjct: 676 VVAPSQTLSDEDYNMLRTTAVNVIRHLGVVGECNIQYALNPVSKDYCIIEVNARLSRSSA 735
Query: 295 FVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVF 354
SK+ GYPLA A K+ + L E+ V + + F P VK +
Sbjct: 736 LASKATGYPLAYTAAKLGLNIPLNEVKNSVTKST-------CACFEP-SLDYCVVKMPRW 787
Query: 355 PWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRD-- 412
K+F V L MKS GEVM I + F A KA R E NL + D D
Sbjct: 788 DLKKFTRVSTELSSSMKSVGEVMSIGRTFEEAIQKA-----IRSTEYANLGFNETDLDID 842
Query: 413 ---------KPKILELAKEFEKLGFGI 430
++ +A F K G+ +
Sbjct: 843 IDYELNNPTDMRVFAIANAFAKKGYSV 869
gb|AAD43968.1|AF119250_1 (AF119250) carbamoyl-phosphate synthetase III [Oreochromis alcalicus
grahami]
Length = 1505
Score = 358 bits (909), Expect = 6e-98
Identities = 203/516 (39%), Positives = 294/516 (56%), Gaps = 21/516 (4%)
Query: 5 VVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEPI 64
+++LG GP IG +EFD+ V ++ +L++ G V+VN NPETVSTD+D D+LYFE +
Sbjct: 976 IMVLGCGPYHIGSSVEFDWCAVSSIRALRQMGKKTVVVNHNPETVSTDFDECDRLYFEEL 1035
Query: 65 VFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFREL 124
E ++DI ++E G I+ GGQ LA+PL +GVKILGT P ID+AE+R +F +
Sbjct: 1036 TLERILDITQQEGCSGCIVSVGGQIANNLAVPLHMSGVKILGTDPLQIDRAEERSVFSSV 1095
Query: 125 IIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXXXA 184
+ +LG+ Q P + E+A A ++G+P L+RPSYVL G AM +VY A
Sbjct: 1096 LDDLGIAQAPWRALSSLEDAFAFANQVGYPCLLRPSYVLSGSAMNVVYGEEEMKRFLEEA 1155
Query: 185 VSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPYSL 244
VS E PV+I KF+ + E++VDAV+ VL+ A+ EH+E+AGVHSGD+ +P ++
Sbjct: 1156 AHVSQEHPVVITKFIRGAREVEVDAVAKNGKVLVHAITEHVEDAGVHSGDATLMLPTQTI 1215
Query: 245 SKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGYPL 304
S+ +E+VK TRK+A A E+ G N Q+ V+ N+V V+E N RASR+ PFVSK+IG
Sbjct: 1216 SQGALEKVKIATRKIAQAFEISGPFNTQFLVKGNDVMVIECNLRASRSFPFVSKAIGVDF 1275
Query: 305 AKIATKVAIGKSLREI-LPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEVD 363
+ATKV + + L E LP + + +P + VK +F W R + D
Sbjct: 1276 INVATKVMVEEPLDEASLPSL-----------ETPIIPVD--YVGVKAPMFSWTRLRDAD 1322
Query: 364 PILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILELAKEF 423
P+L EM STGEV A+ KA LS ++LP+KG + I + D +P L A +
Sbjct: 1323 PVLRCEMASTGEVACFGPNVYSAFLKAMLSTDFKLPQKG-ILIGIQDSFRPSFLATANQL 1381
Query: 424 EKLGFGIYATSGTYKFLKEHGVNAKRV-----LKVSEGRPNVVDMIINGEIHLVINTPSG 478
++ GF +YAT T +L + V A V + P++ +I G I LV+N P+
Sbjct: 1382 KEEGFKLYATEATSAWLCANDVPAIPVAWPTGMGGDNSLPSIKRLISEGHIDLVVNLPNN 1441
Query: 479 K-REKSDAYYIRRACVQFNVPYYTTMRAGYAVLEAI 513
R D + IRR V VP T + EAI
Sbjct: 1442 NTRHVKDNFLIRRMAVDHRVPLITNFQVVKLFAEAI 1477
Score = 208 bits (524), Expect = 9e-53
Identities = 140/399 (35%), Positives = 216/399 (54%), Gaps = 22/399 (5%)
Query: 4 KVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDY---DTADKLY 60
KV++LGSG IGQ EFDY+ A+ +++EE V++N N +V T+ AD +Y
Sbjct: 423 KVLVLGSGGLSIGQAGEFDYSGSQAIKAMKEENLMTVLMNPNIASVQTNEVGPKQADSVY 482
Query: 61 FEPIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPL------QKNGVKILGTKPESIDK 114
F P+ E V +II+ E+P+G++L GGQT L + L + GVK+LGT ESI
Sbjct: 483 FLPVTPEFVTEIIKTERPDGILLSMGGQTALNCGVELFQRGILDQYGVKVLGTPVESIMA 542
Query: 115 AEDRELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDX 174
EDR+LF + ++E+ K PS + +AL+ A++IG+PV+VR +Y LGG + +
Sbjct: 543 TEDRQLFADKLMEINEKIAPSIAVESVSDALRAAEQIGYPVMVRSAYALGGLGSGLCANK 602
Query: 175 XXXXXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAV-MEHIEEAGVHSG 233
A+++S++ +L++K L E++ + V D D + ME+ + G+H+G
Sbjct: 603 EKLEETAQKALAMSNQ--ILVEKSLLGWKEVEYEVVRDVADNCVTVCNMENFDPMGIHTG 660
Query: 234 DSATSIPPYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNN--EVYVLEVNPRASR 291
DS P +LS E ++E K+ L + G N+QYA+ + E ++EVN R SR
Sbjct: 661 DSIVVAPSQTLSNEEYHMLRETAIKVVRHLGIIGECNIQYALHPSSLEYCIIEVNARLSR 720
Query: 292 TVPFVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKE 351
+ SK+ GYPLA +A K+A+G L EI V E+ + F P I + K
Sbjct: 721 SSALASKATGYPLAFVAAKLALGIPLPEIRNAVSEKT-------TACFEPSLDYIVT-KI 772
Query: 352 VVFPWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKA 390
+ RF + +G MKS GEVM I + F + KA
Sbjct: 773 PRWDLDRFHGMSHEIGSSMKSVGEVMAIGRTFEESMQKA 811
ref|NP_001866.1|| carbamoyl-phosphate synthetase 1, mitochondrial >gi|87018|pir||JQ1348
carbamoyl-phosphate synthase (ammonia) (EC 6.3.4.16)
precursor - human >gi|219553|dbj|BAA14328| (D90282)
carbamyl phosphate synthetase I (EC 6.3.4.16) [Homo
sapiens]
Length = 1500
Score = 357 bits (907), Expect = 1e-97
Identities = 200/521 (38%), Positives = 298/521 (56%), Gaps = 19/521 (3%)
Query: 5 VVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEPI 64
+++LG GP IG +EFD+ V ++ +L++ G V+VNCNPETVSTD+D DKLYFE +
Sbjct: 976 MMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDKLYFEEL 1035
Query: 65 VFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFREL 124
E ++DI +E G I+ GGQ P LA+PL KNGVKI+GT P ID+AEDR +F +
Sbjct: 1036 SLERILDIYHQEACGGCIISVGGQIPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAV 1095
Query: 125 IIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXXXA 184
+ EL + Q P T EAL+ AK + +P L+RPSYVL G AM +V+ A
Sbjct: 1096 LDELKVAQAPWKAVNTLNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDEMKKFLEEA 1155
Query: 185 VSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPYSL 244
VS PV++ KF++ + E+++DAV V+ A+ EH+E+AGVHS ++ +P ++
Sbjct: 1156 TRVSQATPVVLTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAGVHSENATLMLPTQTI 1215
Query: 245 SKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGYPL 304
S+ +E+VK+ TRK+A A + G NVQ+ V+ N+V V E N RASR+ P VSK++G
Sbjct: 1216 SQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLVNECNLRASRSFPSVSKTLGVDF 1275
Query: 305 AKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEVDP 364
+ATKV IG+++ EK +P + ++K +F W R + DP
Sbjct: 1276 IDVATKVLIGENVD----------EKHLPTLDHPIIPVD--YVAIKAPMFSWPRLRDADP 1323
Query: 365 ILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILELAKEFE 424
IL EM STGEV + A+ KA LS G+++P+KG + I + +P+ L +A++
Sbjct: 1324 ILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKIPQKG-ILIGIQQSFRPRFLGVAEQLH 1382
Query: 425 KLGFGIYATSGTYKFLKEHGVNAKRVLKVSEGRPN-----VVDMIINGEIHLVINTPSGK 479
GF ++AT T +L + V A V S+ N + +I +G I LVIN P+
Sbjct: 1383 NEGFKLFATEATSDWLNANNVPANPVAWPSQEGQNPSLSSIRKLIRDGSIDLVINLPNNN 1442
Query: 480 RE-KSDAYYIRRACVQFNVPYYTTMRAGYAVLEAIKSIKKL 519
+ D Y IRR V +P T + EA++ +K+
Sbjct: 1443 TKFVHDNYVIRRTAVDSGIPLLTNFQVTKLFAEAVQKSRKV 1483
Score = 195 bits (491), Expect = 7e-49
Identities = 136/399 (34%), Positives = 212/399 (53%), Gaps = 22/399 (5%)
Query: 4 KVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTD---YDTADKLY 60
KV+ILGSG IGQ EFDY+ AV +++EE V++N N +V T+ AD +Y
Sbjct: 424 KVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNEVGLKQADTVY 483
Query: 61 FEPIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGV------KILGTKPESIDK 114
F PI + V ++I+ E+P+G+IL GGQT L + L K GV K+LGT ESI
Sbjct: 484 FLPITPQFVTEVIKAEQPDGLILGMGGQTALNCGVELFKRGVLKEYGVKVLGTSVESIMA 543
Query: 115 AEDRELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDX 174
EDR+LF + + E+ K PS + E+ALK A IG+PV++R +Y LGG I +
Sbjct: 544 TEDRQLFSDKLNEINEKIAPSFAVESIEDALKAADTIGYPVMIRSAYALGGLGSGICPNR 603
Query: 175 XXXXXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAV-MEHIEEAGVHSG 233
A +++++ +L++K + E++ + V D D + ME+++ GVH+G
Sbjct: 604 ETLMDLSTKAFAMTNQ--ILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTG 661
Query: 234 DSATSIPPYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQ--NNEVYVLEVNPRASR 291
DS P +LS + ++ + + L + G N+Q+A+ + E ++EVN + S
Sbjct: 662 DSVVVAPAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNAKMSP 721
Query: 292 TVPFVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKE 351
SK+ GYPLA IA K+A+G L I + + G+ ++ F P + + K
Sbjct: 722 NSALASKTTGYPLAFIAAKIALGIPLPGI-----KNVVSGKT--SACFEPSLDYMVT-KI 773
Query: 352 VVFPWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKA 390
+ RF +G MKS GEVM I + F ++ KA
Sbjct: 774 PRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQKA 812
sp|Q09794|PYR1_SCHPO URA1 PROTEIN [INCLUDES: GLUTAMINE-DEPENDENT CARBAMOYL-PHOSPHATE
SYNTHASE ; ASPARTATE CARBAMOYLTRANSFERASE ]
>gi|2130327|pir||S62450 hypothetical protein SPAC22G7.06c
- fission yeast (Schizosaccharomyces pombe)
>gi|1009456|emb|CAA91130.1| (Z54328) ura1 protein
contains: glutamine-dependent carbamoyl-phosphatesynthase
[Schizosaccharomyces pombe]
Length = 2244
Score = 357 bits (906), Expect = 1e-97
Identities = 203/522 (38%), Positives = 300/522 (56%), Gaps = 29/522 (5%)
Query: 3 KKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFE 62
K V++LGSG RIG +EFD+ V AV +L++ G +MVN NPETVSTDYD AD+LYFE
Sbjct: 1014 KGVMVLGSGVYRIGSSVEFDWCAVRAVRTLRDRGVKTIMVNYNPETVSTDYDEADRLYFE 1073
Query: 63 PIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFR 122
I E V+DI E+E G+I+ GGQT +ALPL + VKILGT PE ID AE+R F
Sbjct: 1074 NIGLETVLDIYEQESSSGIIIAMGGQTANNIALPLHRENVKILGTSPEMIDGAENRFKFS 1133
Query: 123 ELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXX 182
++ ++G+ QP + +EA K +G+PVLVRPSYVL G AM VY
Sbjct: 1134 RMLDDIGVDQPKWKELTSFDEADKFCDTVGYPVLVRPSYVLSGAAMNTVYSQSDLHSYLQ 1193
Query: 183 XAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPY 242
AV+++ + PV+I K+++N+ E+++DAV+ +++ + EH+E AGVHSGD+ +PP
Sbjct: 1194 QAVAINKDHPVVISKYIENAKEIELDAVAREGKMVMHVISEHVENAGVHSGDATLVLPPQ 1253
Query: 243 SLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGY 302
L+ +E + + K+ AL + G N+Q+ ++NE+ V+E N RASR+ PFVSK IG
Sbjct: 1254 DLAPTTIERIVDAAAKIGEALNITGPYNIQFIAKDNEIKVIECNVRASRSFPFVSKVIGV 1313
Query: 303 PLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEV 362
+ +AT V +G ++ P+V LP++ +VK F + R
Sbjct: 1314 DMISMATDVIMGNPIQP-YPDV--------------DLPRD--YVAVKVPQFSFSRLSGA 1356
Query: 363 DPILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVAD-RDKPKILELAK 421
DP+LG EM STGEV AY KA +S G+RLP+K N+ IS+ ++K ++L K
Sbjct: 1357 DPVLGVEMASTGEVACFGHNKFEAYLKAMISTGFRLPKK-NILISIGSYKEKAELLPYVK 1415
Query: 422 EFEKLGFGIYATSGTYKFLKEHGVNAKRVLKVSEGRPN----VVDMIINGEIHLVINTPS 477
+ + + I+AT+GT + E GV K + + N + + N I + IN PS
Sbjct: 1416 KLYENNYNIFATAGTSDYFMESGVPCKYLADLPAEEANNEYSLSAHLANNMIDMYINLPS 1475
Query: 478 GKREKSDAYYI------RRACVQFNVPYYTTMRAGYAVLEAI 513
R + A YI RR + ++VP T ++ ++EAI
Sbjct: 1476 NNRYRRPANYISSGYKSRRLAIDYSVPLVTNVKCAKLMIEAI 1517
Score = 210 bits (530), Expect = 2e-53
Identities = 140/402 (34%), Positives = 212/402 (51%), Gaps = 17/402 (4%)
Query: 2 SKKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYF 61
+K+V+ILGSG IGQ EFDY+ A+ +L+EEG Y +++N N T+ T ADK+YF
Sbjct: 474 AKRVLILGSGGLSIGQAGEFDYSGSQAIKALREEGIYTILINPNIATIQTSKGLADKVYF 533
Query: 62 EPIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPL----QKNGVKILGTKPESIDKAED 117
P+ + V +I++E+P+ + + FGGQT L + + L ++ GVK+LGT ++I ED
Sbjct: 534 LPVNADFVRKVIKQERPDSIYVTFGGQTALNVGIELKDEFEQLGVKVLGTPIDTIITTED 593
Query: 118 RELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXX 177
RELF + E+ K S +A + EEA+K++K+I FPV+VR +Y LGG +
Sbjct: 594 RELFARAMDEINEKCAKSASASSIEEAIKVSKDISFPVIVRAAYALGGLGSGFADNEAEL 653
Query: 178 XXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAV-MEHIEEAGVHSGDSA 236
A + S + VLI++ + E++ + V D D I ME+ + G+H+GDS
Sbjct: 654 IDLCTLAFATSPQ--VLIERSMKGWKEIEYEVVRDAFDNCITVCNMENFDPLGIHTGDSI 711
Query: 237 TSIPPYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQ--NNEVYVLEVNPRASRTVP 294
P +L+ E ++ + L V G N+QYA+ E ++EVN R SR+
Sbjct: 712 VVAPSQTLTDEDYNMLRTTAVNVIRHLGVVGECNIQYALNPFTKEYCIIEVNARLSRSSA 771
Query: 295 FVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVF 354
SK+ GYPLA A K+ + L E+ V + + F P + VK +
Sbjct: 772 LASKATGYPLAFTAAKLGLNIPLNEVKNSVTKVT-------CACFEPSLDYVV-VKIPRW 823
Query: 355 PWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGY 396
K+F V L MKS GEVM I + F A KA + Y
Sbjct: 824 DLKKFTRVSTQLSSAMKSVGEVMSIGRTFEEAIQKAIRAIDY 865
pir||S65074 pyrimidine synthesis protein URA1 - fission yeast
(Schizosaccharomyces pombe) >gi|1154952|emb|CAA57433|
(X81841) carbamoyl-phosphate synthase
(glutamine-hydrolysing) [Schizosaccharomyces pombe]
Length = 2223
Score = 350 bits (889), Expect = 1e-95
Identities = 201/522 (38%), Positives = 297/522 (56%), Gaps = 29/522 (5%)
Query: 3 KKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFE 62
K V++LGSG RIG +EFD+ V +L++ G +MVN NPETVSTDYD AD+LYFE
Sbjct: 993 KGVMVLGSGVYRIGSSVEFDWLQFAQVRTLRDRGVKTIMVNYNPETVSTDYDEADRLYFE 1052
Query: 63 PIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFR 122
I E V+DI E+E G+I+ GGQT +ALPL + VKILGT PE ID AE+R F
Sbjct: 1053 NIGLETVLDIYEQESSSGIIIAMGGQTANNIALPLHRENVKILGTSPEMIDGAENRFKFS 1112
Query: 123 ELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXX 182
++ ++G+ QP + +EA K +G+PVLVRPSYVL G AM VY
Sbjct: 1113 RMLDDIGVDQPKWKELTSFDEADKFCDTVGYPVLVRPSYVLSGAAMNTVYSQSDLHSYLQ 1172
Query: 183 XAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPY 242
AV+++ + PV+I K+++N+ E+++DAV+ +++ + EH+E AGVHSGD+ +PP
Sbjct: 1173 QAVAINKDHPVVISKYIENAKEIELDAVAREGKMVMHVISEHVENAGVHSGDATLVLPPQ 1232
Query: 243 SLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGY 302
L+ +E + + K+ AL + G N+Q+ ++NE+ V+E N RASR+ PFVSK IG
Sbjct: 1233 DLAPTTIERIVDAAAKIGEALNITGPYNIQFIAKDNEIKVIECNVRASRSFPFVSKVIGV 1292
Query: 303 PLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEV 362
+ +AT V +G ++ P+V LP++ +VK F + R
Sbjct: 1293 DMISMATDVIMGNPIQP-YPDV--------------DLPRD--YVAVKVPQFSFSRLSGA 1335
Query: 363 DPILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVAD-RDKPKILELAK 421
DP+LG EM STGEV AY KA +S G+RLP+K N+ IS+ ++K +L K
Sbjct: 1336 DPVLGVEMASTGEVACFGHNKFEAYLKAMISTGFRLPKK-NILISIGSYKEKADVLPYVK 1394
Query: 422 EFEKLGFGIYATSGTYKFLKEHGVNAKRVLKVSEGRPN----VVDMIINGEIHLVINTPS 477
+ + + I+AT+GT + E GV K + + N + + N I + IN PS
Sbjct: 1395 KLYENNYNIFATAGTSDYFMESGVPCKYLADLPAEEANNEYSLSAHLANNMIDMYINLPS 1454
Query: 478 GKREKSDAYYI------RRACVQFNVPYYTTMRAGYAVLEAI 513
R + A YI RR + ++VP T ++ ++EAI
Sbjct: 1455 NNRYRRPANYISSGYKSRRLAIDYSVPLVTNVKCAKLMIEAI 1496
Score = 210 bits (530), Expect = 2e-53
Identities = 140/402 (34%), Positives = 212/402 (51%), Gaps = 17/402 (4%)
Query: 2 SKKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYF 61
+K+V+ILGSG IGQ EFDY+ A+ +L+EEG Y +++N N T+ T ADK+YF
Sbjct: 453 AKRVLILGSGGLSIGQAGEFDYSGSQAIKALREEGIYTILINPNIATIQTSKGLADKVYF 512
Query: 62 EPIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPL----QKNGVKILGTKPESIDKAED 117
P+ + V +I++E+P+ + + FGGQT L + + L ++ GVK+LGT ++I ED
Sbjct: 513 LPVNADFVRKVIKQERPDSIYVTFGGQTALNVGIELKDEFEQLGVKVLGTPIDTIITTED 572
Query: 118 RELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXX 177
RELF + E+ K S +A + EEA+K++K+I FPV+VR +Y LGG +
Sbjct: 573 RELFARAMDEINEKCAKSASASSIEEAIKVSKDISFPVIVRAAYALGGLGSGFADNEAEL 632
Query: 178 XXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAV-MEHIEEAGVHSGDSA 236
A + S + VLI++ + E++ + V D D I ME+ + G+H+GDS
Sbjct: 633 IDLCTLAFATSPQ--VLIERSMKGWKEIEYEVVRDAFDNCITVCNMENFDPLGIHTGDSI 690
Query: 237 TSIPPYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQ--NNEVYVLEVNPRASRTVP 294
P +L+ E ++ + L V G N+QYA+ E ++EVN R SR+
Sbjct: 691 VVAPSQTLTDEDYNMLRTTAVNVIRHLGVVGECNIQYALNPFTKEYCIIEVNARLSRSSA 750
Query: 295 FVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVF 354
SK+ GYPLA A K+ + L E+ V + + F P + VK +
Sbjct: 751 LASKATGYPLAFTAAKLGLNIPLNEVKNSVTKVT-------CACFEPSLDYVV-VKIPRW 802
Query: 355 PWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGY 396
K+F V L MKS GEVM I + F A KA + Y
Sbjct: 803 DLKKFTRVSTQLSSAMKSVGEVMSIGRTFEEAIQKAIRAIDY 844
emb|CAA91059.1| (Z54284) similar to glutamine-dependent carbamoyl-phosphate synthase,
aspartate carbamoyltransferase, dihydroorotase; cDNA EST
EMBL:M89128 comes from this gene; cDNA EST EMBL:D33798
comes from this gene; cDNA EST EMBL:D65291 ...
Length = 2198
Score = 341 bits (865), Expect = 9e-93
Identities = 204/537 (37%), Positives = 292/537 (53%), Gaps = 31/537 (5%)
Query: 1 MSKKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLY 60
M V++LGSG RIG +EFD +CV + L+ GY + VNCNPETVSTDYD D+LY
Sbjct: 933 MKNAVMVLGSGVYRIGSSVEFDSSCVGCIRELKALGYSTITVNCNPETVSTDYDICDRLY 992
Query: 61 FEPIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDREL 120
FE I FE V+D+ EKP+GVIL FGGQ P +A+ L + VKI GT P ID AEDR
Sbjct: 993 FEEISFETVLDVYHLEKPKGVILAFGGQAPNNIAMSLSRAQVKIFGTSPNDIDNAEDRFK 1052
Query: 121 FRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXX 180
F + L + QP + E+A ++G+P L+RPSYVL G AM + ++
Sbjct: 1053 FSRKLESLKISQPQWKKSENMEDAKNFCAQVGYPCLIRPSYVLSGAAMNVAHNAEDLEVF 1112
Query: 181 XXXAVSVSHERPVLIDKFLDNSIELDVDAVS-DGKDVLIGAVMEHIEEAGVHSGDSATSI 239
A V+ E PV++ KF++ + ELDVDAV+ DGK +++ AV EHIE AGVHSGD+
Sbjct: 1113 LKQAAVVAKEHPVVVSKFINEAKELDVDAVALDGK-LVVMAVSEHIENAGVHSGDATLVT 1171
Query: 240 PPYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKS 299
P ++K ++ +K+ T ++A A V G N+Q +NNE+ V+E N R SR+ PFVSK+
Sbjct: 1172 PAQDMNKLTLDRIKDITFRIAEAFNVTGPFNMQLIAKNNELKVIECNLRVSRSFPFVSKT 1231
Query: 300 IGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRF 359
+ Y +AT+ + I + + L K K VK F + R
Sbjct: 1232 LDYDFVALATRAMMASDSPAIRATI----------KPTATLLKGKGRVGVKVPQFSFSRL 1281
Query: 360 PEVDPILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVAD-RDKPKILE 418
D +LG EM STGEV AY KA LS G+ +P K N+FIS+ K ++L+
Sbjct: 1282 AGADVMLGVEMASTGEVACFGTSRCDAYLKALLSTGFVVP-KQNIFISIGGYHAKAEMLK 1340
Query: 419 LAKEFEKLGFGIYATSGTYKFLKEHGVNAKRV----------LKVSEGRPNVVDMIINGE 468
+ KLG+ +Y + GT + + + +N K V K + G +VV+ + N E
Sbjct: 1341 SVEALLKLGYELYGSKGTADYFQSNKINVKPVDWPFEEGSSDEKTASGTRSVVEFLENKE 1400
Query: 469 IHLVINTP---SGKRE----KSDAYYIRRACVQFNVPYYTTMRAGYAVLEAIKSIKK 518
HLVIN P SG ++ Y RR + +P T ++ ++A++ + K
Sbjct: 1401 FHLVINLPIRGSGAYRVSAFRTHGYKTRRMAIDNGIPLITDIKCAKTFIQALEMVGK 1457
Score = 224 bits (565), Expect = 1e-57
Identities = 148/397 (37%), Positives = 213/397 (53%), Gaps = 19/397 (4%)
Query: 3 KKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFE 62
+KV++LGSG IGQ EFDY+ A+ +L+EEG V++N N TV T AD YF
Sbjct: 391 RKVLVLGSGGLTIGQAGEFDYSGAQALKALREEGIRTVLINPNIATVQTSKGFADFTYFL 450
Query: 63 PIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNG------VKILGTKPESIDKAE 116
PI E+V D+I++E+P G++ FGGQT L A+ L K+G V++LGT+ +I K E
Sbjct: 451 PITKEYVTDVIKKERPTGILCTFGGQTALNCAIDLYKDGIFEQYDVQVLGTQINTIMKTE 510
Query: 117 DRELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXX 176
DR+LF + I +G K PS A T E A++ A+E+G+PVLVR +Y LGG +
Sbjct: 511 DRDLFNQEISAIGEKVAPSKAATTMEGAIEAAEELGYPVLVRAAYALGGLGSGFADNREE 570
Query: 177 XXXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAV-MEHIEEAGVHSGDS 235
A ++H VL+DK L E++ + V D D I ME+++ G+H+G+S
Sbjct: 571 LIAIAQQA--LAHSNQVLVDKSLKGWKEVEYEVVRDAYDNCITVCNMENVDPLGIHTGES 628
Query: 236 ATSIPPYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEV--YVLEVNPRASRTV 293
P +LS ++ K+ L + G N+QYA+ + Y++EVN R SR+
Sbjct: 629 VVVAPSQTLSDREYNALRTCAIKVIRHLGIIGECNIQYALDPYSLTYYIIEVNARLSRSS 688
Query: 294 PFVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVV 353
SK+ GYPLA +A K+A+G+ L I V + F P VK
Sbjct: 689 ALASKATGYPLAYVAAKLALGQHLPVIRNSV-------TGTTTACFEP-SLDYCVVKIPR 740
Query: 354 FPWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKA 390
+ +F V +G MKS GEVMGI + F A KA
Sbjct: 741 WDLGKFARVSTQIGSSMKSVGEVMGIGRCFEEALQKA 777
sp|Q91437|PYR1_SQUAC CAD PROTEIN [INCLUDES: GLUTAMINE-DEPENDENT CARBAMOYL-PHOSPHATE
SYNTHASE ; ASPARTATE CARBAMOYLTRANSFERASE ;
DIHYDROOROTASE ] >gi|2118285|pir||A57541 pyrimidine
synthesis multifunctional protein CAD - spiny dogfish
>gi|951096 (U18868) multifunctional protein CAD [Squalus
acanthias]
Length = 2242
Score = 340 bits (862), Expect = 2e-92
Identities = 196/530 (36%), Positives = 287/530 (53%), Gaps = 37/530 (6%)
Query: 5 VVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEPI 64
V+++GSG RIG +EFD+ V + L++ GY MVN NPETVSTDYD D+LYF+ I
Sbjct: 940 VMVIGSGVYRIGSSVEFDWCAVRCIQQLRKMGYKTRMVNYNPETVSTDYDMCDRLYFDEI 999
Query: 65 VFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFREL 124
FE VMDI E E PEG+IL GGQ P +A+ L + +ILGT PESID AE+R F +
Sbjct: 1000 SFEVVMDIYELENPEGIILSMGGQLPNNIAMDLHRQQCRILGTSPESIDTAENRFKFSRM 1059
Query: 125 IIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXXXA 184
+ +G+ QP E + + ++G+P L+RPSYVL G AM + Y A
Sbjct: 1060 LDTIGISQPRWKELSDTESSKQFCTKVGYPCLIRPSYVLSGVAMNVAYSDNDLEKFLSSA 1119
Query: 185 VSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPYSL 244
V+VS E PV+I KF+ + E+DVDAV+ V+ A+ EH+E AGVHSGD+ PP L
Sbjct: 1120 VAVSKEHPVVISKFIQEAKEIDVDAVACDGVVIAVAISEHVENAGVHSGDATLVTPPQDL 1179
Query: 245 SKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGYPL 304
+++ E +K + L+ G N+Q +++++ V+E N R SR+ PFVSK++G +
Sbjct: 1180 NQKTTERIKAIVHAIGQELQATGPFNLQLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDM 1239
Query: 305 AKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEVDP 364
+ATKV +G+ + + L + VK F + R D
Sbjct: 1240 IALATKVIMGEEVEPV------------------GLMTGTGVVGVKVPQFSFSRLAGADV 1281
Query: 365 ILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVAD-RDKPKILELAKEF 423
+LG EM STGEV + AY KA LS G+++P+K N+ +S+ ++K ++L +
Sbjct: 1282 VLGVEMTSTGEVACFGENRYEAYLKAMLSTGFKIPKK-NILLSIGSYKNKSELLSTVQSL 1340
Query: 424 EKLGFGIYATSGTYKFLKEHGVNAKRV----------LKVSEGRPNVVDMIINGEIHLVI 473
E+LG+ +YA+ GT F EHGV K V + E N++D + LVI
Sbjct: 1341 EQLGYNLYASLGTADFYTEHGVKIKAVDWPFEDTDNGCPLKERHRNIMDYLEENHFDLVI 1400
Query: 474 NTP---SGKREKSD----AYYIRRACVQFNVPYYTTMRAGYAVLEAIKSI 516
N SG R S Y RR V ++VP ++ +EA++ +
Sbjct: 1401 NLSMRNSGGRRLSSFVTKGYRTRRLAVDYSVPLIIDIKCTKLFVEALRLV 1450
Score = 213 bits (538), Expect = 2e-54
Identities = 139/396 (35%), Positives = 210/396 (52%), Gaps = 19/396 (4%)
Query: 4 KVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEP 63
KV+ILGSG IGQ EFDY+ A+ +L+EE +V++N N TV T ADK+YF P
Sbjct: 398 KVLILGSGGLSIGQAGEFDYSGSQAIKALKEENVQSVLINPNIATVQTSKGLADKVYFLP 457
Query: 64 IVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNG------VKILGTKPESIDKAED 117
I E+V +I E+P+G++L FGGQT L + LQK G V++LGT SI+ ED
Sbjct: 458 ITPEYVTQVIMNERPDGILLTFGGQTALNCGVELQKRGVLEKYHVRVLGTPVSSIEMTED 517
Query: 118 RELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXX 177
R++F E + E+ PS A T E+A A+ +G+PVLVR ++ LGG +
Sbjct: 518 RKIFVEKMAEINEYVVPSEAAFTLEQAQGAAERLGYPVLVRAAFALGGLGSGFAQNKEEL 577
Query: 178 XXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAV-MEHIEEAGVHSGDSA 236
A +H +L+DK L E++ + V D D I ME+++ G+H+G+S
Sbjct: 578 VTLVTQA--FAHTSQILVDKSLKGWKEIEYEVVRDAYDNCITVCNMENVDPLGIHTGESI 635
Query: 237 TSIPPYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAV--QNNEVYVLEVNPRASRTVP 294
P +L+ + ++ K+ L V G N+QYA+ ++ + +++EVN R SR+
Sbjct: 636 VVAPSQTLNDKEYNLLRTTAIKVIRHLGVVGECNIQYALSPESEQYFIIEVNARLSRSSA 695
Query: 295 FVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVF 354
SK+ GYPLA +A K+A+G L + V +++ P VK +
Sbjct: 696 LASKATGYPLAYVAAKLALGIPLPVLRNSVTNST-------TANYEP-SLDYCVVKVPRW 747
Query: 355 PWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKA 390
+F + +G MKS GEVM I + F A+ KA
Sbjct: 748 DLSKFLRLSTKIGSSMKSVGEVMAIGRNFEEAFQKA 783
ref|NP_004332.1|| carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and
dihydroorotase >gi|1709955|sp|P27708|PYR1_HUMAN CAD
PROTEIN [INCLUDES: GLUTAMINE-DEPENDENT
CARBAMOYL-PHOSPHATE SYNTHASE ; ASPARTATE
CARBAMOYLTRANSFERASE ; DIHYDROOROTASE ]
>gi|1228049|dbj|BAA11423| (D78586) multifunctional
protein CAD [Homo sapiens]
Length = 2225
Score = 334 bits (848), Expect = 9e-91
Identities = 194/527 (36%), Positives = 283/527 (52%), Gaps = 33/527 (6%)
Query: 5 VVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEPI 64
V++LGSG RIG +EFD+ V + L++ GY +MVN NPETVSTDYD D+LYF+ I
Sbjct: 935 VLVLGSGVYRIGSSVEFDWCAVGCIQQLRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEI 994
Query: 65 VFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFREL 124
FE VMDI E E PEGVIL GGQ P +A+ L + ++LGT PE+ID AE+R F L
Sbjct: 995 SFEVVMDIYELENPEGVILSMGGQLPNNMAMALHRQQCRVLGTSPEAIDSAENRFKFSRL 1054
Query: 125 IIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXXXA 184
+ +G+ QP E A + + +G+P +VRPSYVL G AM + Y A
Sbjct: 1055 LDTIGISQPQWRELSDLESARQFCQTVGYPCVVRPSYVLSGAAMNVAYADGDLERFLSSA 1114
Query: 185 VSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPYSL 244
+VS E PV+I KF+ + E+DVDAV+ V A+ EH+E AGVHSGD+ PP +
Sbjct: 1115 AAVSKEHPVVISKFIQEAKEIDVDAVASDGVVAAIAISEHVENAGVHSGDATLVTPPQDI 1174
Query: 245 SKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGYPL 304
+ + +E +K + L+V G N+Q +++++ V+E N R SR+ PFVSK++G L
Sbjct: 1175 TAKTLERIKAIVHAVGQELQVTGPFNLQLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDL 1234
Query: 305 AKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEVDP 364
+AT+V +G+ + + L + VK F + R D
Sbjct: 1235 VALATRVIMGEEVEPV------------------GLMTGSGVVGVKVPQFSFSRLAGADV 1276
Query: 365 ILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILELAKEFE 424
+LG EM STGEV G + AY KA LS G+++P+K L + ++K ++L + E
Sbjct: 1277 VLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIGSYKNKSELLPTVRLLE 1336
Query: 425 KLGFGIYATSGTYKFLKEHGVNAKRV----LKVSEG----RPNVVDMIINGEIHLVINT- 475
LG+ +YA+ GT F EHGV V + +G + ++++ + LVIN
Sbjct: 1337 SLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQRSILEQLAEKNFELVINLS 1396
Query: 476 ---PSGKREKS---DAYYIRRACVQFNVPYYTTMRAGYAVLEAIKSI 516
G+R S Y RR F+VP ++ +EA+ I
Sbjct: 1397 MRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLFVEALGQI 1443
Score = 215 bits (543), Expect = 5e-55
Identities = 141/398 (35%), Positives = 212/398 (52%), Gaps = 22/398 (5%)
Query: 3 KKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFE 62
+KV+ILGSG IGQ EFDY+ A+ +L+EE +++N N TV T ADK+YF
Sbjct: 394 RKVLILGSGGLSIGQAGEFDYSGSQAIKALKEENIQTLLINPNIATVQTSQGLADKVYFL 453
Query: 63 PIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQK------NGVKILGTKPESIDKAE 116
PI +V +I E+P+GV+L FGGQT L + L K GV++LGT E+I+ E
Sbjct: 454 PITPHYVTQVIRNERPDGVLLTFGGQTALNCGVELTKAGVLARYGVRVLGTTVETIELTE 513
Query: 117 DRELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXX 176
DR F + E+G PS + E+A A+ +G+PVLVR ++ +GG + +
Sbjct: 514 DRRAFAARMAEIGEHVAPSEAGNSLEQAQAAAERLGYPVLVRAAFAVGG--LGSGFASNR 571
Query: 177 XXXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSD--GKDVLIGAVMEHIEEAGVHSGD 234
A + +H VL+DK L E++ + V D G V + ME+++ G+H+G+
Sbjct: 572 EELSALVAPAFAHTSQVLVDKSLKGWKEIEYEVVRDAYGNCVTV-CNMENLDPLGIHTGE 630
Query: 235 SATSIPPYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAV--QNNEVYVLEVNPRASRT 292
S P +L+ + +++ K+ L + G NVQYA+ ++ + Y++EVN R SR+
Sbjct: 631 SIVVAPSQTLNDREYQLLRQTAIKVTQHLGIVGECNVQYALNPESEQYYIIEVNARLSRS 690
Query: 293 VPFVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEV 352
SK+ GYPLA +A K+A+G LPE+ + G A F VK
Sbjct: 691 SALASKATGYPLAYVAAKLALGIP----LPELRNSVTGGTAAFEPSV-----DYCVVKIP 741
Query: 353 VFPWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKA 390
+ +F V +G MKS GEVMGI + F A+ KA
Sbjct: 742 RWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFEEAFQKA 779
sp|P08955|PYR1_MESAU CAD PROTEIN [INCLUDES: GLUTAMINE-DEPENDENT CARBAMOYL-PHOSPHATE
SYNTHASE ; ASPARTATE CARBAMOYLTRANSFERASE ;
DIHYDROOROTASE ] >gi|538556|pir||A23443 pyrimidine
synthesis multifunctional protein CAD - golden hamster
Length = 2225
Score = 334 bits (848), Expect = 9e-91
Identities = 194/527 (36%), Positives = 283/527 (52%), Gaps = 33/527 (6%)
Query: 5 VVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEPI 64
V++LGSG RIG +EFD+ V + L++ GY +MVN NPETVSTDYD D+LYF+ I
Sbjct: 935 VLVLGSGVYRIGSSVEFDWCAVGCIQQLRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEI 994
Query: 65 VFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFREL 124
FE VMDI E E P+GVIL GGQ P +A+ L + ++LGT PE+ID AE+R F L
Sbjct: 995 SFEVVMDIYELENPDGVILSMGGQLPNNMAMALHRQQCRVLGTSPEAIDSAENRFKFSRL 1054
Query: 125 IIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXXXA 184
+ +G+ QP E A + + +G+P +VRPSYVL G AM + Y A
Sbjct: 1055 LDTIGISQPQWRELSDLESARQFCQTVGYPCVVRPSYVLSGAAMNVAYTDGDLERFLSSA 1114
Query: 185 VSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPYSL 244
+VS E PV+I KF+ + E+DVDAV+ V A+ EH+E AGVHSGD+ PP +
Sbjct: 1115 AAVSKEHPVVISKFIQEAKEIDVDAVACDGVVSAIAISEHVENAGVHSGDATLVTPPQDI 1174
Query: 245 SKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGYPL 304
+ + +E +K + L+V G N+Q +++++ V+E N R SR+ PFVSK++G L
Sbjct: 1175 TPKTLERIKAIVHAVGQELQVTGPFNLQLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDL 1234
Query: 305 AKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEVDP 364
+AT++ +G+ + I L + VK F + R D
Sbjct: 1235 VALATRIIMGEKVEPI------------------GLMTGSGVVGVKVPQFSFSRLAGADV 1276
Query: 365 ILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILELAKEFE 424
+LG EM STGEV G + AY KA LS G+++P+K L + ++K ++L + E
Sbjct: 1277 VLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIGSYKNKSELLPTVRLLE 1336
Query: 425 KLGFGIYATSGTYKFLKEHGVNAKRV----LKVSEG----RPNVVDMIINGEIHLVINT- 475
LG+ +YA+ GT F EHGV V + +G + +++D + LVIN
Sbjct: 1337 SLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQRSILDQLAENHFELVINLS 1396
Query: 476 ---PSGKREKS---DAYYIRRACVQFNVPYYTTMRAGYAVLEAIKSI 516
G+R S Y RR F+VP ++ +EA+ I
Sbjct: 1397 MRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLFVEALGQI 1443
Score = 219 bits (551), Expect = 6e-56
Identities = 144/398 (36%), Positives = 212/398 (53%), Gaps = 22/398 (5%)
Query: 3 KKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFE 62
+KV+ILGSG IGQ EFDY+ A+ +L+EE +++N N TV T ADK+YF
Sbjct: 394 RKVLILGSGGLSIGQAGEFDYSGSQAIKALKEENIQTLLINPNIATVQTSQGLADKVYFL 453
Query: 63 PIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQK------NGVKILGTKPESIDKAE 116
PI +V +I E+P+GV+L FGGQT L + L K GV++LGT E+I+ E
Sbjct: 454 PITPHYVTQVIRNERPDGVLLTFGGQTALNCGVELTKAGVLARYGVRVLGTPVETIELTE 513
Query: 117 DRELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXX 176
DR F + E+G PS A + E+A A+ +G+PVLVR ++ LGG + +
Sbjct: 514 DRRAFAARMAEIGEHVAPSEAANSLEQAQAAAERLGYPVLVRAAFALGG--LGSGFASTK 571
Query: 177 XXXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSD--GKDVLIGAVMEHIEEAGVHSGD 234
A + +H VLIDK L E++ + V D G V + ME+++ G+H+G+
Sbjct: 572 EELSALVAPAFAHTSQVLIDKSLKGWKEIEYEVVRDAYGNCVTV-CNMENLDPLGIHTGE 630
Query: 235 SATSIPPYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAV--QNNEVYVLEVNPRASRT 292
S P +L+ + ++ K+ L + G NVQYA+ ++ + Y++EVN R SR+
Sbjct: 631 SIVVAPSQTLNDREYQLLRRTAIKVTQHLGIVGECNVQYALNPESEQYYIIEVNARLSRS 690
Query: 293 VPFVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEV 352
SK+ GYPLA +A K+A+G LPE+ + G A F VK
Sbjct: 691 SALASKATGYPLAYVAAKLALGIP----LPELRNSVTGGTAAFEPSL-----DYCVVKIP 741
Query: 353 VFPWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKA 390
+ +F V +G MKS GEVMGI + F A+ KA
Sbjct: 742 RWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFEEAFQKA 779
gi|191333 (J05503) carbamoyl-phosphate synthetase (E.C.6.3.5.5) [Mesocricetus
auratus]
Length = 1300
Score = 334 bits (848), Expect = 9e-91
Identities = 194/527 (36%), Positives = 283/527 (52%), Gaps = 33/527 (6%)
Query: 5 VVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEPI 64
V++LGSG RIG +EFD+ V + L++ GY +MVN NPETVSTDYD D+LYF+ I
Sbjct: 780 VLVLGSGVYRIGSSVEFDWCAVGCIQQLRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEI 839
Query: 65 VFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFREL 124
FE VMDI E E P+GVIL GGQ P +A+ L + ++LGT PE+ID AE+R F L
Sbjct: 840 SFEVVMDIYELENPDGVILSMGGQLPNNMAMALHRQQCRVLGTSPEAIDSAENRFKFSRL 899
Query: 125 IIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXXXA 184
+ +G+ QP E A + + +G+P +VRPSYVL G AM + Y A
Sbjct: 900 LDTIGISQPQWRELSDLESARQFCQTVGYPCVVRPSYVLSGAAMNVAYTDGDLERFLSSA 959
Query: 185 VSVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPYSL 244
+VS E PV+I KF+ + E+DVDAV+ V A+ EH+E AGVHSGD+ PP +
Sbjct: 960 AAVSKEHPVVISKFIQEAKEIDVDAVACDGVVSAIAISEHVENAGVHSGDATLVTPPQDI 1019
Query: 245 SKEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGYPL 304
+ + +E +K + L+V G N+Q +++++ V+E N R SR+ PFVSK++G L
Sbjct: 1020 TPKTLERIKAIVHAVGQELQVTGPFNLQLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDL 1079
Query: 305 AKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEVDP 364
+AT++ +G+ + I L + VK F + R D
Sbjct: 1080 VALATRIIMGEKVEPI------------------GLMTGSGVVGVKVPQFSFSRLAGADV 1121
Query: 365 ILGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILELAKEFE 424
+LG EM STGEV G + AY KA LS G+++P+K L + ++K ++L + E
Sbjct: 1122 VLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIGSYKNKSELLPTVRLLE 1181
Query: 425 KLGFGIYATSGTYKFLKEHGVNAKRV----LKVSEG----RPNVVDMIINGEIHLVINT- 475
LG+ +YA+ GT F EHGV V + +G + +++D + LVIN
Sbjct: 1182 SLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQRSILDQLAENHFELVINLS 1241
Query: 476 ---PSGKREKS---DAYYIRRACVQFNVPYYTTMRAGYAVLEAIKSI 516
G+R S Y RR F+VP ++ +EA+ I
Sbjct: 1242 MRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLFVEALGQI 1288
Score = 219 bits (551), Expect = 6e-56
Identities = 144/398 (36%), Positives = 212/398 (53%), Gaps = 22/398 (5%)
Query: 3 KKVVILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFE 62
+KV+ILGSG IGQ EFDY+ A+ +L+EE +++N N TV T ADK+YF
Sbjct: 239 RKVLILGSGGLSIGQAGEFDYSGSQAIKALKEENIQTLLINPNIATVQTSQGLADKVYFL 298
Query: 63 PIVFEHVMDIIEREKPEGVILQFGGQTPLKLALPLQK------NGVKILGTKPESIDKAE 116
PI +V +I E+P+GV+L FGGQT L + L K GV++LGT E+I+ E
Sbjct: 299 PITPHYVTQVIRNERPDGVLLTFGGQTALNCGVELTKAGVLARYGVRVLGTPVETIELTE 358
Query: 117 DRELFRELIIELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXX 176
DR F + E+G PS A + E+A A+ +G+PVLVR ++ LGG + +
Sbjct: 359 DRRAFAARMAEIGEHVAPSEAANSLEQAQAAAERLGYPVLVRAAFALGG--LGSGFASTK 416
Query: 177 XXXXXXXAVSVSHERPVLIDKFLDNSIELDVDAVSD--GKDVLIGAVMEHIEEAGVHSGD 234
A + +H VLIDK L E++ + V D G V + ME+++ G+H+G+
Sbjct: 417 EELSALVAPAFAHTSQVLIDKSLKGWKEIEYEVVRDAYGNCVTV-CNMENLDPLGIHTGE 475
Query: 235 SATSIPPYSLSKEIVEEVKEQTRKLAVALEVKGLINVQYAV--QNNEVYVLEVNPRASRT 292
S P +L+ + ++ K+ L + G NVQYA+ ++ + Y++EVN R SR+
Sbjct: 476 SIVVAPSQTLNDREYQLLRRTAIKVTQHLGIVGECNVQYALNPESEQYYIIEVNARLSRS 535
Query: 293 VPFVSKSIGYPLAKIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEV 352
SK+ GYPLA +A K+A+G LPE+ + G A F VK
Sbjct: 536 SALASKATGYPLAYVAAKLALGIP----LPELRNSVTGGTAAFEPSL-----DYCVVKIP 586
Query: 353 VFPWKRFPEVDPILGPEMKSTGEVMGIDKEFGLAYYKA 390
+ +F V +G MKS GEVMGI + F A+ KA
Sbjct: 587 RWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFEEAFQKA 624
gb|AAD18071| (AF129814) carbamyl phosphate synthetase II; CPS.B domain
[Drosophila melanogaster]
Length = 752
Score = 330 bits (837), Expect = 2e-89
Identities = 195/525 (37%), Positives = 280/525 (53%), Gaps = 34/525 (6%)
Query: 6 VILGSGPNRIGQGIEFDYACVHAVFSLQEEGYYAVMVNCNPETVSTDYDTADKLYFEPIV 65
+++GSG RIG +EFD+ V + L++ +M+N NPETVSTDYD D+LYFE I
Sbjct: 53 IVVGSGVYRIGSSVEFDWCAVGCLRELRKLQRPTIMINYNPETVSTDYDMCDRLYFEEIS 112
Query: 66 FEHVMDIIEREKPEGVILQFGGQTPLKLALPLQKNGVKILGTKPESIDKAEDRELFRELI 125
FE VMDI E E EG+IL GGQ P +A+ L + K+LGT PESID AE+R F ++
Sbjct: 113 FEVVMDIYEMENSEGIILSMGGQLPNNIAMDLHRQQAKVLGTSPESIDCAENRFKFSRML 172
Query: 126 IELGLKQPPSGTARTKEEALKIAKEIGFPVLVRPSYVLGGRAMRIVYDXXXXXXXXXXAV 185
G+ QP + A++ +E+G+P LVRPSYVL G AM + Y A
Sbjct: 173 DRKGILQPRWKELTNLQSAIEFCEEVGYPCLVRPSYVLSGAAMNVAYSNQDLETYLNAAS 232
Query: 186 SVSHERPVLIDKFLDNSIELDVDAVSDGKDVLIGAVMEHIEEAGVHSGDSATSIPPYSLS 245
VS E PV+I KFL + E+DVDAV+ +L AV EH+E AGVHSGD+ PP L+
Sbjct: 233 EVSREHPVVISKFLTEAKEIDVDAVASDGRILCMAVSEHVENAGVHSGDATLVTPPQDLN 292
Query: 246 KEIVEEVKEQTRKLAVALEVKGLINVQYAVQNNEVYVLEVNPRASRTVPFVSKSIGYPLA 305
E +E +K T LA L+V G N+Q +NNE+ V+E N R SR+ PFVSK++ +
Sbjct: 293 AETLEAIKRITCDLASVLDVTGPFNMQLIAKNNELKVIECNVRVSRSFPFVSKTLDHDFV 352
Query: 306 KIATKVAIGKSLREILPEVFERLEKGEAHFASDFLPKEKKIFSVKEVVFPWKRFPEVDPI 365
AT+ +G + + D L K+ VK F + R D
Sbjct: 353 ATATRAIVGLDVEPL-----------------DVLHGVGKV-GVKVPQFSFSRLAGADVQ 394
Query: 366 LGPEMKSTGEVMGIDKEFGLAYYKAQLSAGYRLPEKGNLFISVADRDKPKILELAKEFEK 425
LG EM STGEV AY KA +S G+++P+ L + + K ++L ++ K
Sbjct: 395 LGVEMASTGEVACFGDNRYEAYLKAMMSTGFQIPKNAVLLSIGSFKHKMELLPSIRDLAK 454
Query: 426 LGFGIYATSGTYKFLKEHGVNAKRVL---------KVSEGRPNVVDMIINGEIHLVINTP 476
+G+ +YA+ GT F EHGVN + V ++ ++ + + N + LVIN P
Sbjct: 455 MGYKLYASMGTGDFYAEHGVNVESVQWTFDKTTPDDINGELRHLAEFLANKQFDLVINLP 514
Query: 477 ---SGKREKSD----AYYIRRACVQFNVPYYTTMRAGYAVLEAIK 514
G R S Y RR V +++P T ++ ++E+++
Sbjct: 515 MSGGGARRVSSFMTHGYRTRRLAVDYSIPLVTDVKCTKLLVESMR 559
Database: Non-redundant GenBank CDS
translations+PDB+SwissProt+SPupdate+PIR
Posted date: Jan 12, 2000 2:26 PM
Number of letters in database: 136,724,657
Number of sequences in database: 444,417
Lambda K H
0.317 0.138 0.385
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 140872888
Number of Sequences: 444417
Number of extensions: 5997393
Number of successful extensions: 16338
Number of sequences better than 10.0: 272
Number of HSP's better than 10.0 without gapping: 168
Number of HSP's successfully gapped in prelim test: 104
Number of HSP's that attempted gapping in prelim test: 15508
Number of HSP's gapped (non-prelim): 373
length of query: 537
length of database: 136,724,657
effective HSP length: 59
effective length of query: 478
effective length of database: 110,504,054
effective search space: 52820937812
effective search space used: 52820937812
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.6 bits)
S2: 72 (32.5 bits)
